Happiness: Role of Dopamine and Serotonin on Mood and Negative
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Molecular Signatures of G-Protein-Coupled Receptors A
REVIEW doi:10.1038/nature11896 Molecular signatures of G-protein-coupled receptors A. J. Venkatakrishnan1, Xavier Deupi2, Guillaume Lebon1,3,4,5, Christopher G. Tate1, Gebhard F. Schertler2,6 & M. Madan Babu1 G-protein-coupled receptors (GPCRs) are physiologically important membrane proteins that sense signalling molecules such as hormones and neurotransmitters, and are the targets of several prescribed drugs. Recent exciting developments are providing unprecedented insights into the structure and function of several medically important GPCRs. Here, through a systematic analysis of high-resolution GPCR structures, we uncover a conserved network of non-covalent contacts that defines the GPCR fold. Furthermore, our comparative analysis reveals characteristic features of ligand binding and conformational changes during receptor activation. A holistic understanding that integrates molecular and systems biology of GPCRs holds promise for new therapeutics and personalized medicine. ignal transduction is a fundamental biological process that is comprehensively, and in the process expand the current frontiers of required to maintain cellular homeostasis and to ensure coordi- GPCR biology. S nated cellular activity in all organisms. Membrane proteins at the In this analysis, we objectively compare known structures and reveal cell surface serve as the communication interface between the cell’s key similarities and differences among diverse GPCRs. We identify a external and internal environments. One of the largest and most diverse consensus structural scaffold of GPCRs that is constituted by a network membrane protein families is the GPCRs, which are encoded by more of non-covalent contacts between residues on the transmembrane (TM) than 800 genes in the human genome1. GPCRs function by detecting a helices. -
The Influence of Emotional States on Short-Term Memory Retention by Using Electroencephalography (EEG) Measurements: a Case Study
The Influence of Emotional States on Short-term Memory Retention by using Electroencephalography (EEG) Measurements: A Case Study Ioana A. Badara1, Shobhitha Sarab2, Abhilash Medisetty2, Allen P. Cook1, Joyce Cook1 and Buket D. Barkana2 1School of Education, University of Bridgeport, 221 University Ave., Bridgeport, Connecticut, 06604, U.S.A. 2Department of Electrical Engineering, University of Bridgeport, 221 University Ave., Bridgeport, Connecticut, 06604, U.S.A. Keywords: Memory, Learning, Emotions, EEG, ERP, Neuroscience, Education. Abstract: This study explored how emotions can impact short-term memory retention, and thus the process of learning, by analyzing five mental tasks. EEG measurements were used to explore the effects of three emotional states (e.g., neutral, positive, and negative states) on memory retention. The ANT Neuro system with 625Hz sampling frequency was used for EEG recordings. A public-domain library with emotion-annotated images was used to evoke the three emotional states in study participants. EEG recordings were performed while each participant was asked to memorize a list of words and numbers, followed by exposure to images from the library corresponding to each of the three emotional states, and recall of the words and numbers from the list. The ASA software and EEGLab were utilized for the analysis of the data in five EEG bands, which were Alpha, Beta, Delta, Gamma, and Theta. The frequency of recalled event-related words and numbers after emotion arousal were found to be significantly different when compared to those following exposure to neutral emotions. The highest average energy for all tasks was observed in the Delta activity. Alpha, Beta, and Gamma activities were found to be slightly higher during the recall after positive emotion arousal. -
About Emotions There Are 8 Primary Emotions. You Are Born with These
About Emotions There are 8 primary emotions. You are born with these emotions wired into your brain. That wiring causes your body to react in certain ways and for you to have certain urges when the emotion arises. Here is a list of primary emotions: Eight Primary Emotions Anger: fury, outrage, wrath, irritability, hostility, resentment and violence. Sadness: grief, sorrow, gloom, melancholy, despair, loneliness, and depression. Fear: anxiety, apprehension, nervousness, dread, fright, and panic. Joy: enjoyment, happiness, relief, bliss, delight, pride, thrill, and ecstasy. Interest: acceptance, friendliness, trust, kindness, affection, love, and devotion. Surprise: shock, astonishment, amazement, astound, and wonder. Disgust: contempt, disdain, scorn, aversion, distaste, and revulsion. Shame: guilt, embarrassment, chagrin, remorse, regret, and contrition. All other emotions are made up by combining these basic 8 emotions. Sometimes we have secondary emotions, an emotional reaction to an emotion. We learn these. Some examples of these are: o Feeling shame when you get angry. o Feeling angry when you have a shame response (e.g., hurt feelings). o Feeling fear when you get angry (maybe you’ve been punished for anger). There are many more. These are NOT wired into our bodies and brains, but are learned from our families, our culture, and others. When you have a secondary emotion, the key is to figure out what the primary emotion, the feeling at the root of your reaction is, so that you can take an action that is most helpful. . -
Zest and Work
Journal of Organizational Behavior J. Organiz. Behav. 30, 161–172 (2009) Published online in Wiley InterScience (www.interscience.wiley.com) DOI: 10.1002/job.584 Zest and work CHRISTOPHER PETERSON1*, NANSOOK PARK2, NICHOLAS HALL3 AND MARTIN E.P.SELIGMAN 3 1University of Michigan, Michigan, U.S.A. 2University of Rhode Island, Rhode Island, U.S.A. 3University of Pennsylvania, Pennsylvania, U.S.A. Summary Zest is a positive trait reflecting a person’s approach to life with anticipation, energy, and excitement. In the present study, 9803 currently employed adult respondents to an Internet site completed measures of dispositional zest, orientation to work as a calling, and satisfaction with work and life in general. Across all occupations, zest predicted the stance that work was a calling (r ¼.39), as well as work satisfaction (r ¼.46) and general life satisfaction (r ¼.53). Zest deserves further attention from organizational scholars, especially how it can be encouraged in the workplace. Copyright # 2009 John Wiley & Sons, Ltd. Your work is to discover your work, and then with all of your heart to give yourself to it.—the Buddha Introduction Recent years have seen a widespread call for the study of work organizations in which people can be well and do well (Cameron, Dutton, & Quinn, 2003; Gardner, Csikszentmihalyi, & Damon, 2001; Luthans, 2003; Wright, 2003). The emergence of the positive perspective within organizational psychology has brought new attention to the venerable topic of work satisfaction (Hoppock, 1935). Satisfaction with the work that one does is seen not just as a contributor to good performance and increased profitability but as a worthy end in its own right (Heslin, 2005). -
A Faithful Love Yields Enduring Happiness July 2018
A faithful love yields enduring happiness July 2018 Married love is also faithful and exclusive of all other, and this until death. This is how husband and wife understood it on the day on which, fully aware of what they were doing, they freely vowed themselves to one another in marriage. Though this fidelity of husband and wife sometimes presents difficulties, no one has the right to assert that it is impossible; it is, on the contrary, always honorable and meritorious. The example of countless married couples proves not only that fidelity is in accord with the nature of marriage, but also that it is the source of profound and enduring happiness. (Humanae vitae no. 9) Reflection There tends to be a common view in the culture that freedom means doing anything one wants, anytime, with no restraints. Such a view makes it difficult to understand the vowed commitment to lifelong, faithful marriage. Bl. Pope Paul VI in Humanae vitae reminds the world that the Church offers a different view of freedom, a view that authentic freedom can only be found when it is ordered towards the truth. When we live our lives according to the truth, as with the example of a husband and wife living a life of faithfulness and fidelity to each other in marriage, we experience the “profound and enduring happiness” and authentic freedom our hearts are truly longing for. How have you experienced the fruits of living faithful love in your life? Are there areas God may be inviting you to grow in trust and faithfulness in your relationship with Him? Intercessory Prayer to Paul VI God our Father, Empower married couples to live the beautiful call to free, total, faithful, fruitful love in the vow they exchanged in holy matrimony. -
(12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness Et Al
USOO6264,917B1 (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness et al. (45) Date of Patent: Jul. 24, 2001 (54) TARGETED ULTRASOUND CONTRAST 5,733,572 3/1998 Unger et al.. AGENTS 5,780,010 7/1998 Lanza et al. 5,846,517 12/1998 Unger .................................. 424/9.52 (75) Inventors: Jo Klaveness; Pál Rongved; Dagfinn 5,849,727 12/1998 Porter et al. ......................... 514/156 Lovhaug, all of Oslo (NO) 5,910,300 6/1999 Tournier et al. .................... 424/9.34 FOREIGN PATENT DOCUMENTS (73) Assignee: Nycomed Imaging AS, Oslo (NO) 2 145 SOS 4/1994 (CA). (*) Notice: Subject to any disclaimer, the term of this 19 626 530 1/1998 (DE). patent is extended or adjusted under 35 O 727 225 8/1996 (EP). U.S.C. 154(b) by 0 days. WO91/15244 10/1991 (WO). WO 93/20802 10/1993 (WO). WO 94/07539 4/1994 (WO). (21) Appl. No.: 08/958,993 WO 94/28873 12/1994 (WO). WO 94/28874 12/1994 (WO). (22) Filed: Oct. 28, 1997 WO95/03356 2/1995 (WO). WO95/03357 2/1995 (WO). Related U.S. Application Data WO95/07072 3/1995 (WO). (60) Provisional application No. 60/049.264, filed on Jun. 7, WO95/15118 6/1995 (WO). 1997, provisional application No. 60/049,265, filed on Jun. WO 96/39149 12/1996 (WO). 7, 1997, and provisional application No. 60/049.268, filed WO 96/40277 12/1996 (WO). on Jun. 7, 1997. WO 96/40285 12/1996 (WO). (30) Foreign Application Priority Data WO 96/41647 12/1996 (WO). -
Last Decade of Unconventional Methodologies for the Synthesis Of
Review molecules Last Decade of Unconventional Methodologies for theReview Synthesis of Substituted Benzofurans Last Decade of Unconventional Methodologies for the Lucia Chiummiento *, Rosarita D’Orsi, Maria Funicello and Paolo Lupattelli Synthesis of Substituted Benzofurans Department of Science, Via dell’Ateneo Lucano, 10, 85100 Potenza, Italy; [email protected] (R.D.); [email protected] (M.F.); [email protected] (P.L.) Lucia Chiummiento * , Rosarita D’Orsi, Maria Funicello and Paolo Lupattelli * Correspondence: [email protected] Department of Science, Via dell’Ateneo Lucano, 10, 85100 Potenza, Italy; [email protected] (R.D.); Academic Editor: Gianfranco Favi [email protected] (M.F.); [email protected] (P.L.) Received:* Correspondence: 22 April 2020; [email protected] Accepted: 13 May 2020; Published: 16 May 2020 Abstract:Academic This Editor: review Gianfranco describes Favi the progress of the last decade on the synthesis of substituted Received: 22 April 2020; Accepted: 13 May 2020; Published: 16 May 2020 benzofurans, which are useful scaffolds for the synthesis of numerous natural products and pharmaceuticals.Abstract: This In review particular, describes new the intramolecular progress of the and last decadeintermolecular on the synthesis C–C and/or of substituted C–O bond- formingbenzofurans, processes, which with aretransition-metal useful scaffolds catalysi for thes or synthesis metal-free of numerous are summarized. natural products(1) Introduction. and (2) Ringpharmaceuticals. generation via In particular, intramolecular new intramolecular cyclization. and (2.1) intermolecular C7a–O bond C–C formation: and/or C–O (route bond-forming a). (2.2) O– C2 bondprocesses, formation: with transition-metal (route b). -
Note N-Methyltyramine, a Gastrin-Releasing Factor in Beer, and Structurally Related Compounds As Agonists for Human Trace Amine-Associated Receptor 1
_ Food Science and Technology Research, 26 (2), 313 317, 2020 Copyright © 2020, Japanese Society for Food Science and Technology http://www.jsfst.or.jp doi: 10.3136/fstr.26.313 Note N-Methyltyramine, a Gastrin-releasing Factor in Beer, and Structurally Related Compounds as Agonists for Human Trace Amine-associated Receptor 1 1,2* 1 1 1 3 3 Hiroto OHTA , Yuka MURAKAMI , Youhei TAKEBE , Kaori MURASAKI , Kenji OSHIMA , Hiroshi YOSHIHARA 1 and Shigeru MORIMURA 1Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami Chuo-ku, Kumamoto 860- 8555, Japan 2Department of Applied Microbial Technology, Faculty of Biotechnology and Life Science, Sojo University, 4-22-1 Ikeda Nishi-ku, Kumamoto 860-0082, Japan 3Department of Biological and Chemical Systems Engineering, National Institute of Technology, Kumamoto College, 2627 Hirayama-shinmachi, Yatsushiro, Kumamoto 866-8501, Japan Received September 30, 2019 ; Accepted December 5, 2019 N-Methyltyramine (N-MeTA) is known as a gastrin-releasing factor in beer. In this study, the agonistic actions of N-MeTA as well as tyramine (TA)/β-phenylethylamine (PEA) and their other N-methylated derivatives were examined to elucidate their structure-activity relationships, using a secreted placental alkaline phosphatase (SEAP)-based reporter assay in HEK-293 cells transiently expressing a G protein- coupled receptor, human trace amine-associated receptor 1 (hTAAR1). We detected the agonistic actions of six test compounds, including N-MeTA (EC50 = 6.78 µM), on hTAAR1. The agonistic actions were reduced depending on the number of N-methyl groups introduced into TA and PEA; the order of potency is PEA > N-methylphenylethylamine > TA ≈ N,N-dimethylphenylethylamine ≥ N-MeTA ≥ N,N-dimethyltyramine. -
Cathinone-Derived Psychostimulants Steven J
Review Cite This: ACS Chem. Neurosci. XXXX, XXX, XXX−XXX pubs.acs.org/chemneuro DARK Classics in Chemical Neuroscience: Cathinone-Derived Psychostimulants Steven J. Simmons,*,† Jonna M. Leyrer-Jackson,‡ Chicora F. Oliver,† Callum Hicks,† John W. Muschamp,† Scott M. Rawls,† and M. Foster Olive‡ † Center for Substance Abuse Research (CSAR), Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania 19140, United States ‡ Department of Psychology, Arizona State University, Tempe, Arizona 85281, United States ABSTRACT: Cathinone is a plant alkaloid found in khat leaves of perennial shrubs grown in East Africa. Similar to cocaine, cathinone elicits psychostimulant effects which are in part attributed to its amphetamine-like structure. Around 2010, home laboratories began altering the parent structure of cathinone to synthesize derivatives with mechanisms of action, potencies, and pharmacokinetics permitting high abuse potential and toxicity. These “synthetic cathinones” include 4-methylmethcathinone (mephedrone), 3,4-methylenedioxypyrovalerone (MDPV), and the empathogenic agent 3,4-methylenedioxymethcathinone (methylone) which collectively gained international popularity following aggressive online marketing as well as availability in various retail outlets. Case reports made clear the health risks associated with these agents and, in 2012, the Drug Enforcement Agency of the United States placed a series of synthetic cathinones on Schedule I under emergency order. Mechanistically, cathinone and synthetic derivatives work by augmenting monoamine transmission through release facilitation and/or presynaptic transport inhibition. Animal studies confirm the rewarding and reinforcing properties of synthetic cathinones by utilizing self-administration, place conditioning, and intracranial self-stimulation assays and additionally show persistent neuropathological features which demonstrate a clear need to better understand this class of drugs. -
Positive Psychology
7 WAYS TO APPLY POSITIVE PSYCHOLOGY Learn practical, proven strategies to live a happier, more engaged and more meaningful life. We all want to live happier, more engaging and more meaningful lives. The science of positive psychology contributes new Introduction insights and proven strategies to increase wellbeing in individuals, workplaces and communities. After years classifying and repairing the worst of human experience, positive psychology emerged to help us flourish and learn from the best. This rich and varied field now spans many areas, building on philosophies and practices from Aristotle to Maslow. This eBook introduces you to some of the most practical and research-backed ways to apply positive psychology to increase happiness, wellbeing and effectiveness—in your life, at work, at home and with the people you care for, help and lead. You will learn: • How to maximise the power of positivity to create sustainable pathways to happiness and success. • Seven positive psychology practices - “[Positive Psychology is] the from optimism to mindfullness. scientific study of positive • Tips to apply these practices at work, at human functioning and home and when helping people. flourishing on multiple levels.” We look forward to inspiring you and others to live a Martin Seligman &Mihaly Csikszentmihalyi happier, more engaged and fulfilling life! The Langley Group team © 2015 Langley Group. All rights reserved 2 Positive psychology 7 POSITIVE PRACTICES Positive emotion 1 Generating positive emotions helps broaden and build our resources and moves us toward greater wellbeing. Spearheaded by Martin Seligman and Mindset Mihaly Csikszentmihalyi in 1998, positive 2 psychology focuses on exploring and Adopting a positive attitude and Growth Mindset enhances learning and opens our expanding what makes life worthwhile, mind to new ways to raise happiness levels. -
Effects of Acute Tyrosine/Phenylalanine Depletion on the Selective Processing of Smoking-Related Cues and the Relative Value of Cigarettes in Smokers
Psychopharmacology DOI 10.1007/s00213-007-0995-5 ORIGINAL INVESTIGATION Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers Brian Hitsman & James MacKillop & Anne Lingford-Hughes & Tim M. Williams & Faheem Ahmad & Sally Adams & David J. Nutt & Marcus R. Munafò Received: 16 May 2007 /Accepted: 18 October 2007 # Springer-Verlag 2007 Abstract tive mood, and expired carbon monoxide (CO) levels were Rationale Acute tyrosine/phenylalanine depletion (ATPD) is measured at various timepoints through 300 min. Participants a validated neurobiological challenge that results in reduced smoked at hourly intervals to prevent acute nicotine with- dopaminergic neurotransmission, allowing examination of drawal during testing. the effects of a hypodopaminergic state on craving-related Results The TYR/PHE-free mixture, as compared to the processes. BAL mixture, was associated with a greater increase in CO Objectives We studied 16 nonabstaining smokers (>10 levels from baseline ( p=0.01). Adjusting for the potential cigarettes/day; 9 males; age 20–33 years) to whom was confounding influence of between-condition differences in administered a tyrosine/phenylalanine-free mixture (TYR/ CO levels across time, TYR/PHE-free mixture was asso- PHE-free) and a balanced amino acid mixture (BAL) in a ciated with increased demand for cigarettes ( p=0.01) and double-blind, counterbalanced, crossover design. decreased attentional bias toward smoking-related words Methods Subjective cigarette craving, attentional bias to ( p=0.003). There were no significant differences between smoking-related word cues, relative value of cigarettes, nega- conditions in either subjective craving or depressed or anxious mood ( p values>0.05). -
Learning Objectives
2/26/2019 To help ensure the integrity of competition for Dirty Dozen: High Risk athletes, sports organizations and fans Sport Supplement worldwide. Ingredients Lara Gray, MS, RD, CSSD Senior Director of Education, Board Certified Sports Dietitian 1 Welcome! Learning Objectives Things to note: At the end of the presentation, attendees will 1. It is required by the BOC for Certified Athletic Trainers that you are actively be better able to: present in the live event AND complete the post-webinar survey in order to • Identify dietary ingredients that pose a threat to drug tested athletes. receive your CEU certificate. • Explain how high risk dietary ingredients are being used in sports 2. CEU Statements of Credit (if applicable) supplements. will be emailed to attendees no later than Friday, March 1st. • Analyze sports supplements for high risk dietary ingredients. 3. Please use the “Questions” box in GoToWebinar. Questions will be reviewed by the moderator and answered at the Drug Free Sport International (BOC AP# P8729) is approved by the Board of Certification, Inc. to end. provide continuing education to Athletic Trainers. This program is eligible for a maximum of 1 Category A hour/CEU. ATs should claim only those hours actually spent in the educational program. 4. Download today’s handouts from the “Handouts” tab. 1 2/26/2019 Today: An In-Depth Look 40% - 100% ATHLETES USE SUPPLEMENTS • Type of sport • Level of competition • Definition of supplements Garthe, Ina, and Ronald J. Maughan. "Athletes and Supplements: Prevalence and Perspectives." International journal of sport nutrition and exercise metabolism 28.2 (2018): 126‐138.