MONITORAMENTO EM BIOTECNOLOGIA Desenvolvimento Científico E Tecnológico Foco – Brasil

MONITORAMENTO EM BIOTECNOLOGIA Desenvolvimento científico e tecnológico Foco – Brasil

2° Relatório

Executor: Sistema de Informação sobre a Indústria Química (SIQUIM) Escola de Química (EQ) Universidade Federal do Rio de Janeiro (UFRJ)

Janeiro / 2005

EQUIPE:

Coordenação Geral: Profª Dra. Adelaide Antunes

Coordenação Técnica: Dra. Claudia Canongia

Pesquisadores: Simone Alencar Engenheira Química, Doutoranda EQ/UFRJ Nicomedes Déscio Pereira Neto Químico Industrial, Mestrando EQ/UFRJ Andressa Gusmão Estagiária, Escola de Química EQ/UFRJ Daniel Hoefle Estagiário, Escola de Química EQ/UFRJ Fernando Tibau Estagiário, Escola de Química EQ/UFRJ Max Arnor Estagiário, Ciências Atuariais IM/UFRJ

SUMÁRIO

Introdução ...... 5 1. Artigos em biotecnologia ...... 8 I - Artigos relacionados com a Amazônia ...... 10 1. TEMA: BIODIVERSIDADE/BIOPROSPECÇÃO...... 11 2. TEMA: DEFESA AGROPECUÁRIA...... 13 3. TEMA: MUDANÇAS CLIMÁTICAS GLOBAIS...... 20 4. TEMA: PROGRAMAS DE DESCOBERTA ...... 21 II - Artigos relacionados com o Brasil ...... 23 1. TEMA: BIODIVERSIDADE/BIOPROSPECÇÃO ...... 24 2. TEMA: BIOECONOMIA...... 26 3. TEMA: BIORREMEDIAÇÃO...... 26 4. TEMA: DEFESA AGROPECUÁRIA ...... 27 5. TEMA: INTEGRAÇÃO: ALIMENTAÇÃO, NUTRIÇÃO E SAÚDE ...... 46 6. TEMA: MUDANÇAS CLIMÁTICAS GLOBAIS ...... 46 7. TEMA: PROGRAMAS DE DESCOBERTA...... 47 8. TEMA: SEGURANÇA BIOLÓGICA ...... 50 III - Artigos publicados por autores vinculados a instituições brasileiras ...... 51 1. TEMA: BIODIVERSIDADE/BIOPROSPECÇÃO ...... 52 2. TEMA: BIOECONOMIA...... 58 3. TEMA: BIOINDÚSTRIA ...... 58 4. TEMA: BIOINFORMÁTICA ...... 59 5. TEMA: BIORREMEDIAÇÃO...... 60 6. TEMA: CERTIFICAÇÃO DE QUALIDADE BIOLÓGICA ...... 61 7. TEMA: DEFESA AGROPECUÁRIA ...... 61 8. TEMA: FARMACOGENÉTICA ...... 68 9. TEMA: FERTILIDADE E REPRODUÇÃO ANIMAL ...... 68 10. TEMA: INTEGRAÇÃO: ALIMENTAÇÃO, NUTRIÇÃO E SAÚDE ...... 69 11. TEMA: MUDANÇAS CLIMÁTICAS GLOBAIS ...... 70 12. TEMA: PROGRAMAS DE DESCOBERTA ...... 73 13. TEMA: SEGURANÇA BIOLÓGICA...... 96 14. TEMA: SUSTENTABILIDADE AMBIENTAL ...... 98 2. Patentes em biotecnologia ...... 100 I. Patentes relacionadas com a Amazônia...... 101 1. TEMA: BIOINDÚSTRIA ...... 101 2. TEMA: INTEGRAÇÃO: ALIMENTAÇÃO, NUTRIÇÃO E SAÚDE ...... 103 3. TEMA: PROGRAMAS DE DESCOBERTA...... 106 4. TEMA: SUSTENTABILIDADE AMBIENTAL...... 108 II. Patentes relacionadas com o Brasil...... 111 1. TEMA: BIOINDÚSTRIA ...... 111 2. TEMA: BIORREMEDIAÇÃO...... 128 3. TEMA: INTEGRAÇÃO: ALIMENTAÇÃO, NUTRIÇÃO E SAÚDE ...... 130 4. TEMA: PROGRAMAS DE DESCOBERTA...... 139

5. TEMA: SUSTENTABILIDADE AMBIENTAL...... 147 III. Patentes depositadas no Brasil ...... 155 1. TEMA: BIODIVERSIDADE/BIOPROSPECÇÃO ...... 156 2. TEMA: BIOECONOMIA...... 156 3. TEMA: BIOINDÚSTRIA ...... 157 4. TEMA: BIORREMEDIAÇÃO...... 173 5. TEMA: CERTIFICAÇÃO DE QUALIDADE BIOLÓGICA ...... 173 6. TEMA: FERTILIDADE E REPRODUÇÃO ANIMAL ...... 174 7. TEMA: INTEGRAÇÃO: ALIMENTAÇÃO, NUTRIÇÃO E SAÚDE ...... 175 8. TEMA: PROGRAMAS DE DESCOBERTA...... 181 9. TEMA: SEGURANÇA BIOLÓGICA ...... 195 10. TEMA: SUSTENTABILIDADE AMBIENTAL ...... 195

Introdução

Este relatório tem como objetivo apresentar os títulos de artigos e patentes, do período de 1994-2004, que contém no título ou no resumo os temas e respectivos termos solicitados pelo CGEE e estão relacionados com a Amazônia e Brasil. Desta forma tem-se três sub-conjuntos de artigos e patentes: • Relacionados com a Amazônia • Relacionados com o Brasil • Artigos publicados por autores de instituições brasileiras e patentes depositadas no Brasil.

As fontes bibliográficas para este estudo foram a Web of Science para identificação de artigos científicos e Derwent Innovation Index para identificação de patentes.

As pesquisas foram realizadas a partir dos temas e termos propostos pelos especialistas em biotecnologia e entregue pelo Prof. Sérgio Salles (UNICAMP representando o CGEE), apresentados na tabela a seguir.

Tabela – Temas e termos de busca para monitoramento em biotecnologia BIOTECNOLOGIA TEMAS TERMOS Bancos de germoplasma Herbários e demais formas de conservação ex situ Legislação ágil e eficiente Plantas/Animais e Microbiota Biodiversidade marinha 1.Biodiversidade/ Bioprospecção Acesso ao patrimônio Genético Conhecimento tradicional Mercado de produtos da floresta Propriedade intelectual Fitomedicamentos Mercado Nacional e Internacional Patentes Cadeia produtiva 2. Bioeconomia Inovação tecnológica Projetos pré-competitivos Produtos orgânicos 3. Bioindústria Cadeia produtiva Produtos pré-competitivos Valor agregado Bioprodutos Produtos com alta, média e baixa incorporação de (bio)tecnologia Marketing de Biotecnologia Branding

BIOTECNOLOGIA TEMAS TERMOS Designing Redes Software 4. Bioinformática Gestão do conhecimento Aplicações para Genomas, proteomas e biodiversidade Meio ambiente 5. Biorremediação Indústrias com passivo ambiental alto Microorganismos Legislação 6. Bioterrorismo Capacitação de pessoal Inteligência Coleções certificadas 7. Certificação de qualidade biológica Qualidade industrial Microorganismos 8. Competitividade da Economia Nacional Fertilidade e Reprodução Animal Controle de pragas Espécies invasoras Normas internacionais Infra-estrutura para biossegurança Normas de qualidade 9. Defesa Agropecuária Capacidade Antecipativa Leitura de Cenários Capacidade de Integração de Orgãos e Arcabouços Legais Sistemas Efetivos de Monitoramento Recursos Humanos Fármacos Fitomedicamentos 10. Farmacogenética Custo/benefício Genoma de populações Melhoria genômica Competitividade 11. Fertilidade e reprodução animal Clonagem Células tronco Novos fármacos Capital de risco Eficiência das agências públicas 12. Financiamento Formas ágeis de avaliação Capitalização das empresas Espaço para micro-empresas Bancos de dados Propriedade da informação Pessoal qualificado 13. Gestão de Informação Biológica Desenvolvimento de software Integração de Sistemas Redes Cooperativas Nutracêuticos (Alimentos Funcionais) Novas formulações Alimentos especiais para populações especiais Qualidade de vida 14. Integração: alimentação, nutrição e Bem estar saúde Produtos orgânicos Organismos Geneticamente Modificados Produção de Vacinas em Plantas e Animais Produção de Hormônios

BIOTECNOLOGIA TEMAS TERMOS Informação 15. Inteligência Quarentenária Espécies invasoras Qualidade agropecuária Ver Biodiversidade/ Bioprospecção 16. Metagenômica/ Prospecção Gênica Remediação ambiental Monitoramento Mudanças nos padrões de produção Processos Evolutivos 17. Mudanças climáticas globais Vetores de Transformação Gênica Expressão Gênica e Ambiente Erradicação de sensibilidade a fotoperíodo Incentivos de P&D voltado para produtos Novas formas de abordagens do material biológico Clonagem Stem Cells Genômica Funcional Farmacogenética 18. Programas de Descoberta Engenharia Genética Nanobiotecnologia Proteômica Evolução direcionada In silico biology Biologia de sistemas Informação Banco de dados Níveis de segurança Laboratórios existentes 19. Segurança Biológica Normas internacionais Pessoal qualificado Qualidade da Segurança Biológica Fluxo Gênico Percepção Pública OGMs Biodisponibilidade de Nutrientes 20. Sustentabilidade Ambiental Bioinseticidas Biofungicidas Controle Biológico

1. Artigos em biotecnologia

Na tabela a seguir estão assinalados os temas/termos onde foram localizados documentos nos três subconjuntos: artigos relacionados à Amazônia, artigos relacionados ao Brasil e artigos de autores vinculados à instituições brasileiras, com a ocorrência dos termos no título (tit) ou resumo (res). Artigos - Distribuição por temas e termos dos artigos em biotecnologia

Autores de Relacionados Relacionados Instituições à Amazônia ao Brasil TEMAS/TERMOS brasileiras TIT RES TIT RES. TIT RES TEMA: Biodiversidade/ Bioprospecção X X X X X X Bancos de germoplasma X X X X Herbários e demais formas de X X X X X conservação ex situ Legislação ágil e eficiente X X X X Biodiversidade marinha X X X X X Termos da Acesso ao patrimônio Biodiversidade/ X X X Genético Bioprospecção Conhecimento tradicional X X X X Mercado de produtos da X X X floresta Propriedade intelectual X X X Fitomedicamentos X X X X X X TEMA: Bioeconomia X X X X X TEMA: Bioindústria Termos da Bioprodutos X X X X Bioindústria TEMA: Bioinformática X X X X Aplicações para Termos da Genomas, proteomas e X X Bioinformática biodiversidade TEMA: Biorremediação X X X Termos da Meio ambiente X X X Biorremediação Microorganismos X X X TEMA: Bioterrorismo X X TEMA: Certificação de qualidade biológica Termos da Coleções Certificação de certificadas X X X qualidade Microorganismos biológica X X X TEMA: Defesa Agropecuária X X X X X X Termos da Sistemas Efetivos de Defesa Monitoramento Agropecuária X X X X X TEMA: Farmacogenética X X X TEMA: Fertilidade e reprodução animal X X X X Termos da Fertilidade e Clonagem reprodução X TEMA: Integração: alimentação, nutrição e saúde X X X

Autores de Relacionados Relacionados Instituições à Amazônia ao Brasil TEMAS/TERMOS brasileiras TIT RES TIT RES. TIT RES Nutracêuticos (Alimentos X X X Termos da Funcionais) Integração: Qualidade de vida X alimentação, Produção de Vacinas em nutrição e saúde X X X X X Plantas e Animais

TEMA: Metagenômica/ Prospecção Gênica X X TEMA: Mudanças climáticas globais X X X X X X TEMA: Programas de Descoberta n.a. n.a. n.a. n.a. n.a. n.a. Clonagem X X X X X X Stem Cells X X X X Termos da Genômica Funcional X X X Programas de Descoberta Farmacogenética X Engenharia Genética X X X Proteômica X X X X X TEMA: Segurança Biológica X X X X X Termos da Níveis de segurança X X Segurança Biológica Fluxo Gênico X TEMA: Sustentabilidade Ambiental X X Termos da OGMs X X Sustentabilidade Bioinseticidas X X X Ambiental Biofungicidas X X

I - Artigos relacionados com a Amazônia

A tabela a seguir mostra a freqüência de artigos que citam a Amazônia no título e no resumo, para os temas e termos deste estudo. Relacionados à TEMA/TERMOS DE BIOTECNOLOGIA Amazônia TITULO RESUMO TEMA: Biodiversidade/ Bioprospecção 19 290 Bancos de germoplasma 0 1 Herbários e demais formas de 0 13 conservação ex situ Legislação ágil e eficiente 0 4 TERMOS da Biodiversidade marinha 0 2 Biodiversidade/ Bioprospecção Acesso ao patrimônio Genético 0 1

Conhecimento tradicional 1 3 Mercado de produtos da floresta 0 43 Propriedade intelectual 0 1 Fitomedicamentos 2 10 TEMA: Bioeconomia 0 2 TEMA: Bioindústria 0 0 Termos da Bioprodutos 0 2 Bioindústria TEMA: Bioinformática 0 2 TEMA: Biorremediação 0 1 Termos da Meio ambiente 0 1 Biorremediação Microorganismos 0 1

TEMA: Certificação de qualidade biológica 0 0 Termos da Certificação de qualidade Coleções certificadas 0 1 biológica TEMA: Defesa Agropecuária 103* 730*

Termos da Sistemas Efetivos de Monitoramento 0 42 Defesa Agropecuária

TEMA: Fertilidade e reprodução animal 0 2 TEMA: Integração: alimentação, nutrição e saúde 0 8 Termos da Produção de Vacinas em Plantas e Integração: alimentação, nutrição 0 21 Animais e saúde TEMA: Mudanças climáticas globais 10 270 TEMA: Programas de Descoberta n.a. n.a. Termos da Clonagem 3 43 Programas de Descoberta Proteômica 1 2 TEMA: Segurança Biológica 0 1 TEMA: Sustentabilidade Ambiental 0 3 * Estes números se referem à artigos sobre agropecuária e Amazônia n.a. = não se aplica. O tema programas de descoberta não é um termo de busca.

Nos itens que se seguem são apresentados os títulos, autores e instituição de correspondência dos artigos relacionados aos temas/termos deste estudo. Utilizou-

11 se a instituição de correspondência como referencia do local de realização da pesquisa. Embora não tenha sido feita análise de conteúdo dos artigos localizados, cabe destacar que através dos títulos observa-se que há artigos relacionados com a região amazônica de outros países.

1. TEMA: BIODIVERSIDADE/BIOPROSPECÇÃO

Apresenta-se a seguir os títulos dos 19 artigos que citam Amazônia no título, sobre o tema biodiversidade/bioprospecção, com seus respectivos autores e instituição de correspondência.

Instituição de Título Autores correspondência Miles, L The impact of global climate change on tropical Grainger, A Univ Leeds forest biodiversity in Amazonia Phillips, O Mathieu, J Rossi, JP A multi-scale study of soil macrofauna Grimaldi, M IRD biodiversity in Amazonian pastures Mora, P Lavelle, P Rouland, C Malocas and barracones. Tradition, biodiversity, and participation in the Colombian Serje, M - Amazon Traditional knowledge and areas of biodiversity Pinton, F Univ Paris in Brazilian Amazonia Multivariate mapping of spatial Rose, S Univ Leeds variation in biodiversity in Peruvian Amazonia Grainger, A A biodiversity assessment of bats (Chiroptera) Sampaio, EM in a tropical lowland Kalko, EKV rainforest of Central Amazonia, Bernard, E Univ Ulm including methodological and Rodriguez-Herrera, B conservation considerations Handley, CO Prospects for conserving Moegenburg, SM Smithsonian Inst biodiversity in Amazonian extractive reserves Levey, DJ Environmental impacts generating biodiversity: Ecological Zent, EL Inst Venezolano behaviors of the Hoti of the Zent, S Invest Cient Maigualida Mountain Range, Venezuelan Amazon Biodiversity as an environmental service in Brazil's Amazonian Natl Inst Res Fearnside, PM forests: risks, value and Amazon conservation Kress, WJ Heyer, WR Acevedo, P Coddington, J Cole, D Amazonian biodiversity: assessing Smithsonian Erwin, TL conservation priorities with taxonomic data Inst Meggers, BJ Pogue, M Thorington, RW Vari, RP Weitzman, MJ

Instituição de Título Autores correspondência Weitzman, SH Resources lacking to save Amazon biodiversity Kauffmann-Zeh, A What satellite imagery and large-scale field studies can tell about biodiversity patterns in Tuomisto, H Univ Turku Amazonian forests The role of ecological knowledge in explaining Tuomisto, H UNIV TURKU biogeography and biodiversity in Amazonia Ruokolainen, K Amazon biodiversity - a renewable natural- SEIDL, PR UFRJ resource Future-oriented mapping of biodiversity in GOTTLIEB, OR FIOCRUZ MS amazonia TUOMISTO, H RUOKOLAINEN, K KALLIOLA, R Dissecting amazonian biodiversity UNIV TURKU LINNA, A DANJOY, W RODRIGUEZ, Z The amazon rain-forest, sustainable DORE, MHI development and the biodiversity convention - CORNELL UNIV NOGUEIRA, JM a political-economy perspective DALE, VH Relating patterns of land-use change to faunal PEARSON, SM OAK RIDGE NATL LAB biodiversity in the central amazon OFFERMAN, HL ONEILL, RV Monitoring biodiversity - analysis amazonian RIEDE, K UNIV FREIBURG rain-forest sounds

Em relação aos termos referentes ao tema biodiversidade/bioprospecção, em dois termos (conhecimento tradicional e fitomedicamentos) foram localizados artigos que referem-se em seu título à Amazônia. Os títulos dos artigos, seus autores e instituição de correspondência são apresentados a seguir. a. Conhecimento tradicional Título Autores Instituição de correspondência Traditional knowledge and areas of biodiversity Pinton, F Univ Paris in Brazilian Amazonia

b. Fitomedicamentos Instituição de Título Autores correspondência Miller, MJS Vergnolle, N McKnight, W Musah, RA Inhibition of neurogenic inflammation by the Davison, CA Albany Med Coll amazonian herbal medicine Sangre de grado Trentacosti, AM Thompson, JH Sandoval, M Wallace, JL

Instituição de Título Autores correspondência Miller, MJS MacNaughton, WK Zhang, XJ Thompson, JH Treatment of gastric ulcers and diarrhea with the Charbonnet, Albany Med Coll Amazonian herbal medicine sangre de grado RM Bobrowski, P Lao, J Trentacosti, AM Sandoval, M

2. TEMA: DEFESA AGROPECUÁRIA

Não foram localizados artigos que tratem especificamente sobre defesa agropecuária na Amazônia. A título de ilustração apresentam-se a seguir os títulos dos 103 artigos que citam Amazônia no título, relacionados a agropecuária, com seus respectivos autores e instituição de correspondência. Instituição de Título Autores correspondência Cerri, CEP Bernoux, A Chaplot, V Assessment of soil property spatial variation in an Volkoff, B Amazon pasture: basis for selecting an Univ Sao Paulo Victoria, RL agronomic experimental area Melillo, JM Paustian, K Cerri, CC Lindgarde, F Traditional versus agricultural lifestyle among Widen, I Shuar women of the Ecuadorian Amazon: Effects Lund Univ Gebb, M on leptin levels Ahren, B Kurzatkowski, D Martius, C Litter decomposition, microbial biomass and Hofer, H Zentrum activity of soil organisms in three agroforestry Garcia, M Entwicklungsforsch sites in central Amazonia Forster, B Beck, L Vlek, P Are agricultural production and forest conservation compatible? Agricultural diversity, Perz, SG Univ Florida agricultural incomes and primary forest cover among small farm colonists in the Amazon Sakai, RK Fitzjarrald, DR Land-use change effects on local energy, water, Moraes, OLL and carbon balances in an Amazonian Staebler, RM SUNY Albany agricultural field Acevedo, OC Czikowsky, MJ Da Silva, R

Instituição de Título Autores correspondência Brait, E Miranda, V Modelling species and spacing effects on root Schlegel, P zone water dynamics using Hydrus-2D in an Huwe, B Univ Bayreuth Amazonian agroforestry system Teixeira, WG Martius, C Hofer, H Microclimate in agroforestry systems in central Garcia, MVB Amazonia: does canopy closure matter to soil Ctr Dev Res Rombke, J organisms? Forster, B Hanagarth, W Increasing the profitability of traditional, planted Schroth, G rubber agroforests at the Tapajos river, Brazilian Moraes, V Univ Bayreuth Amazon da Mota, MSS Evaluation of soil fertility in smallholder Alfaia, SSRibeiro, Inst Nacl de Pesquisas da agroforestry systems and pastures in western GANobre, ADLuizao, Amazonia Amazonia RCLuizao, FJ Martius, C Litter fall, litter stocks and decomposition rates in Hofer, H rainforest and agroforestry sites in central Garcia, MVB Ctr Dev Res ZEF Bonn Amazonia Rombke, J Hanagarth, W Baar, R Floristic inventory of secondary vegetation in Cordeiro, MD Inst Soil Sci & Forest Nutr agricultural systems of East-Amazonia Denich, M Folster, H Rueda, BL Blake, RW Nicholson, CF Production and economic potentials of cattle in Fox, DG pasture-based systems of the western Amazon Tedeschi, LO Cornell Univ region of Brazil Pell, AN Fernandes, ECM Valentim, JF Carneiro, JC Agricultural land-use change in Brazilian Cardille, JA Amazonia between 1980 and 1995: Evidence Univ Wisconsin Foley, JA from integrated satellite and census data Yanesha agriculture in the upper Peruvian Hamlin, CC Amazon: Persistence and change fifteen years Ohio Univ Salick, J down the 'road' Land reform and land-use changes in the lower Futemma, C amazon: Implications for agricultural Indiana Univ Brondizio, ES intensification Barros, E Neves, A Development of the soil macrofauna community Blanchart, E Inst Nacl de Pesquisas da under silvopastoral and agrosilvicultural Fernandes, ECM Amazonia systems in Amazonia Wandelli, E Lavelle, P Dinkelmeyer, H Lehmann, J Renck, A Nitrogen uptake from N-15-enriched fertilizer by Trujillo, L Univ Bayreuth four tree crops in an Amazonian agroforest da Silva, JP Gebauer, G Kaiser, K Rubber agroforests at the Tapajo's river, Schroth, G Univ Bayreuth

Instituição de Título Autores correspondência Brazilian Amazon - environmentally benign land Coutinho, P use systems in an old forest frontier region Moraes, VHF Albernaz, AL Soil microbial activities in tree-based cropping Menyailo, OVLehmann, systems and natural forests of the Central Russian Acad Sci JCravo, MDZech, W Amazon, Brazil Cows, colonists and trees: rethinking cattle and Muchagata, M Univ E Anglia environmental degradation in Brazilian Amazonia Brown, K Social determinants and land use correlates of agricultural technology adoption in a forest Perz, SG Univ Florida frontier: A case study in the Brazilian Amazon Landscape dynamics and equilibrium in areas of slash-and-burn agriculture with short and long Metzger, JP Univ Sao Paulo fallow period (Bragantina region, NE Brazilian Amazon) Characterizing patterns of agricultural land use Cardille, JA in Amazonia by merging satellite classifications Foley, JA Univ Wisconsin and census data Costa, MH An evaluation of agroforestry systems as a rural Yamada, M Tokyo Univ Agr & Technol development option for the Brazilian Amazon Gholz, HL Growth and yield of some indigenous trees in an Yamada, M Amazonian agroforestry system: a rural-history- Univ Florida Gholz, HL based analysis Schroth, G Mineral nutrition of peach palm (Bactris gasipaes) Elias, MEA in Amazonian agroforestry and Macedo, JLV Natl Inst Res Amazon recommendations for foliar analysis Mota, MSS Lieberei, R Wild animals in the garden: Conserving wildlife in Naughton-Treves, L Univ Wisconsin amazonian agroecosystems Elias, MEA Mineral nutrition, growth and yields of annatto Schroth, G trees (Bixa orellana) in agroforestry on an Macedo, JLV Natl Inst Res Amazon Amazonian ferralsol Mota, MSS D'Angelo, SA Cavalcante, FA Martins, R Calving of interval on cattle of Nellore in the Campello, CC - Eastern Amazonia Lobo, RNB Martins, GA Cavalcante, FA Martins, R Gestation lenght of Nellore cattle in the oriental Campello, CC - Amazonia Lobo, RNB Martins, GA Cavalcante, FA Martins, R Post-partum interval of Nellore cattle in the Campello, CC - oriental Amazonia Lobo, RNB Martins, GA Schroth, G Conversion of secondary forest into agroforestry D'Angelo, SA and monoculture plantations in Amazonia: Teixeira, WG Natl Inst Res Amazon consequences for biomass, litter and soil carbon Haag, D stocks after 7 years Lieberei, R Genetic analysis of Eucalyptus urophylla and E- Muro-Abad, JI grandis clones selected in commercial crops Gomes, EA Univ Fed Vicosa from the Brazilian Amazon by RAPD markers Cancio, ON

Instituição de Título Autores correspondência de Araujo, E The implication of property rights for joint Otsuki, T agriculture-timber productivity in the Brazilian Hardie, IW World Bank Amazon Reis, EJ Seasonal effects on microorganisms in the Marschner, P rhizosphere of two tropical plants in a polyculture Marino, W Univ Adelaide agroforestry system in Central Amazonia, Brazil Lieberei, R A tropical forest transition? Agricultural change, Rudel, TK out-migration, and secondary forests in the Bates, D Rutgers State Univ Ecuadorian Amazon Machinguiashi, R Agricultural colonization and malaria on the Singer, BH Princeton Univ Amazon frontier De Castro, MC Lehmann, J Cravo, MD Phosphorus management for perennial crops in de Macedo, JLV Cornell Univ central Amazonian upland soils Moreira, A Schroth, G Lehmann, J Gunther, D Inorganic and organic soil phosphorus and sulfur da Mota, MS pools in an Amazonian multistrata agroforestry Cornell Univ de Almeida, MP system Zech, W Kaiser, K Spatial and temporal patterns of Amazon rainfall - Consequences for the planning of agricultural Sombroek, W ISRIC occupation and the protection of primary forests Root activity patterns in an Amazonian Lehmann, J agroforest with fruit trees determined by P-32, P- Muraoka, T Univ Bayreuth 33 and N-15 applications Zech, W Soil nitrogen mineralization under tree crops and Schroth, G a legume cover crop in multi-strata agroforestry Salazar, E Natl Inst Res Amazon in central Amazonia: Spatial and temporal Da Silva, JP patterns Growth, yields and mineral nutrition of cupuacu Schroth, GElias, (Theobroma grandiflorum) in two multi-strata MEAMacedo, INPA agroforestry systems on a ferralitic Amazonian JLVD'Angelo, upland soil at four fertilization levels SALieberei, R Burning of Amazonian rainforests: burning Fearnside, PM efficiency and charcoal formation in forest cleared Graca, PMLD Natl Inst Res Amazon for cattle pasture near Manaus, Brazil Rodrigues, FJA Cattle, deforestation and development in the Amazon: An economic, agronomic and Evans, S Humboldt State Univ environmental perspective. Colonist farm income, off-farm work, cattle, and Murphy, LL Univ N Carolina differentiation in Ecuador's northern Amazon From sustainable development to "productive conservation": Forest conservation options and Perz, SG Univ Florida agricultural income and assets in the Brazilian Amazon Soil phosphorus availability and fine root McGrath, DA proliferation in Amazonian agroforests 6 years Duryea, ML Univ South following forest conversion Cropper, WP Peri-urban agroforestry in the Brazilian Amazon Slinger, VAV Univ Florida McGrath, DA Nitrogen and phosphorus cycling in an Duryea, ML Amazonian agroforest eight years following Univ South Comerford, NB forest conversion Cropper, WP

Instituição de Título Autores correspondência Schroth, G Teixeira, WG Effect of five tree crops and a cover crop in Seixas, R multi-strata agroforestry at two fertilization levels Embrapa Amazonia da Silva, LF on soil fertility and soil solution chemistry in Ocidental Schaller, M central Amazonia Macedo, JLV Zech, W Litter dynamics and monthly fluctuations in soil McGrath, DA phosphorus availability in an Amazonian Comerford, NB Univ South agroforest Duryea, ML Schroth, G Nutrient concentrations and acidity in ferralitic soil Seixas, R EMBRAPA Amazonia under perennial cropping, fallow and primary da Silva, LF Ocidental forest in central Amazonia Teixeira, WG Zech, W Faminow, MD Dahl, C Smallholder risk, cattle and deforestation in the Vosti, S Int Dev Res Ctr western Brazilian Amazon Witcover, J Oliveira, S Carpentier, C Agroforestry performance on small farms in Browder, JO Virginia Polytech Inst & Amazonia: Findings from the Rondonia Pedlowski, MA State Univ agroforestry pilot project Deforestation and cattle ranching in the Brazilian Walker, RMoran, Amazon: External capital and household Michigan State Univ EAnselin, L processes Salcedo, JMV Camargo, EP Malaria control in an agro-industrial settlement Secretaria Saude Krieger, H of Rondonia (Western Amazon Region, Brazil) Rondonia da Silva, LHP Camargo, LMA The implication of property rights for joint Otsuki, T agriculture-timber productivity in the Brazilian - Reis, E Amazon. Davidson, EA Verchot, LV Effects of soil water content on soil respiration in Cattanio, JH Woods Hole Res Ctr forests and cattle pastures of eastern Amazonia Ackerman, IL Carvalho, JEM Estimating the loss of agricultural productivity in Univ London London Sch Weinhold, D the Amazon Econ & Polit Sci Kids and crops. The concept of fertility among Veth, B Univ Utrecht the Wayana Indians in he Guyana Amazon Distribution patterns of the litter macrofauna in agroforestry and monoculture plantations in Vohland, K Univ Hamburg central Amazonia as affected by plant species Schroth, G and management Earthworm populations in a savanna- Araujo, Y Cent Univ Venezuela agroforestry system of Venezuelan Amazonia Lopez-Hernandez, D Schroth, G Distribution of throughfall and stemflow in multi- da Silva, LF strata agroforestry, perennial monoculture, Wolf, MA Univ Hamburg fallow and primary forest in central Amazonia, Teixeira, WG Brazil Zech, W 1492 and the loss of Amazonian crop genetic Inst Nacl Pesquisas resources. I. The relation between domestication Clement, CR Amazonia and human population decline

Instituição de Título Autores correspondência 1492 and the loss of amazonian crop genetic Inst Nacl Pesquisas Clement, CR resources. II. Crop biogeography at contact Amazonia Selection for a toxic staple crop: meeting Wilson, WM nutritional requirements in a blackwater basin of - Dufour, DL Northwest Amazonia. Pasture or permanent crops after slash-and-burn Fujisaka, S cultivation? Land-use choice in three Amazon Ctr Int Agr Trop White, D colonies Manioc agriculture and sedentism in Amazonia: Heckenberger, MJ Univ Fed Rio de Janeiro the Upper Xingu example Arevalo, LA The effect of cattle grazing on soil physical and Alegre, JC chemical properties in a silvopastoral system in Int Ctr Res Agroforestry Bandy, DE the Peruvian Amazon Szott, LT Fujisaka, SCastilla, The effects of forest conversion on annual crops CEscobar, GRodrigues, and pastures: Estimates of carbon emissions and Ctr Int Agr Trop VVeneklaas, plant species loss in a Brazilian Amazon colony EJThomas, RFisher, M Vosti, SA Policy issues in agroforestry: Technology Witcover, J adoption and regional integration in the western Int Food Policy Res Inst Oliveira, S Brazilian Amazon Faminow, M Molnar, L Eradication of brucellosis from a cattle herd in the Molnar, E Fed Univ Para Amazonian region (short communication) Barbosa, R Vale, WG Kauffman, JB Fire in the Brazilian Amazon 2. Biomass, nutrient Cummings, DL Oregon State Univ pools and losses in cattle pastures Ward, DE Holscher, D Dynamic of soil chemical parameters in shifting Ludwig, B Univ Kassel agriculture in the Eastern Amazon Moller, RF Folster, H Brazilian Amazonian caboclo agriculture: effect SilvaForsberg, MC INDIANA UNIV of fallow period on maize yield Fearnside, PM Ludwig, B Modelling of sorption experiments and seepage Holscher, D data of an Amazonian Ultisol subsoil under Khanna, P UNIV GOTTINGEN cropping fallow Prenzel, J Folster, H Estimation of the increase in deforestation clue to agricultural and pastoral activities in the Bidone, ED Brazilian Western Amazon: an approach based UNIV FED FLUMINENSE CadaxoSobrinho, ES on the relationship between production and productivity Indigenous market-oriented agroforestry: Coomes, OT MCGILL UNIV dissecting local diversity in western Amazonia Burt, GJ Market incorporation, agricultural change, and UNIV CALIF LOS sustainability among the Machigueuga Indians of Henrich, J ANGELES the Peruvian Amazon Kuchmeister, H Flowering, pollination, nectar standing crop, and SilberbauerGottsberger, nectaries of Euterpe precatoria (Arecaceae), an - I Amazonian rain forest palm Gottsberger, G Holscher, D Nutrient input-output budget of shifting Moller, RF UNIV GOTTINGEN agriculture in Eastern Amazonia Denich, M Folster, H

Instituição de Título Autores correspondência Spatial economics of local demand for cattle Faminow, MD UNIV MANITOBA products in Amazon development Swidden-fallow agroforestry in Amazonia: CTR INT FORESTRY DeJong, W Diversity at close distance RES Vertebrate predation of Brazil-nuts (Bertholletia Peres, CA excelsa, Lecythidaceae), an agouti-dispersed Schiesari, LC UNIV E ANGLIA Amazonian seed crop: A test of the escape DiasLeme, CL hypothesis Fujisaka, S Slash-and-burn agriculture, conversion to Bell, W pasture, and deforestation in two Brazilian Thomas, N CTR INT AGR TROP Amazon colonies Hurtado, L Crawford, E Management of tropical legume cover crops in LunaOrea, P the Bolivian Amazon to sustain crop yields and - Wagger, MG soil productivity Dynamics of soil physical properties in Alegre, JC ICRAF,ESTAC EXPT SAN Amazonian agroecosystems inoculated with Pashanasi, B RAMON earthworms Lavelle, P

Organizations and intensifications: Campesino federations, rural livelihoods and agricultural Bebbington, A UNIV COLORADO technology in the Andes and Amazonia Thapa, KK Deforestation, land use, and women's Bilsborrow, RE UNIV N CAROLINA agricultural activities in the Ecuadorian Amazon Murphy, L Upland agricultural and forestry development in Serrao, EAS the Amazon: Sustainability, criticality and Nepstad, D - resilience Walker, R Smith, NJH Agroforestry trajectories among smallholders in Falesi, IC the Brazilian Amazon: Innovation and resiliency UNIV FLORIDA Alvim, PD in pioneer and older settled areas Serrao, EAS Scatena, FN Walker, RT Homma, AKO Cropping and fallowing sequences of small deConto, AJ farms in the ''terra firme'' landscape of the Ferreira, CAP US FOREST SERV Brazilian Amazon: A case study from Santarem, Carvalho, RD Para daRocha, ACPN Santos, AIMD deOliveira, PM Agricultural production in Brazilian Amazonia: Barrow, CJ UNIV COLL SWANSEA Problems and prospects Smith, NJH Fik, TJ Agroforestry developments and potential in the Alvim, PDT UNIV FLORIDA Brazilian Amazon Falesi, IC Serrao, EAS STANDING CROP AND DISTRIBUTION OF FISH IN DRIFTING AND ATTACHED FLOATING HENDERSON, UNIV OXFORD MEADOW WITHIN AN UPPER AMAZONIAN PAHAMILTON, HF VARZEA LAKE ECONOMIC AND ECOLOGICAL TONIOLO, A INST HOMEM & MEIO PERSPECTIVES ON AGRICULTURE IN THE UHL, C AMBIENTE AMAZONIA EASTERN AMAZON AGROFORESTRY STRATEGIES FOR FERNANDES, ECM - ALLEVIATING SOIL CHEMICAL CONSTRAINTS MATOS, JCD

Instituição de Título Autores correspondência TO FOOD AND FIBER PRODUCTION IN THE BRAZILIAN AMAZON DASILVA, JF TUCCI, CAF GRADUATE COURSE IN AGROFORESTRY AT OLIVEIRA, WS - THE UNIVERSITY-OF-AMAZONAS, BRAZIL CRUZ, FGG DEMENDONCA, MS MARCELO, L UNSTABLE HYPOENDEMIC MALARIA IN CAMARGO, A RONDONIA (WESTERN AMAZON REGION, FERREIRA, MU BRAZIL) - EPIDEMIC OUTBREAKS AND WORK- UNIV SAO PAULO KRIEGER, H ASSOCIATED INCIDENCE IN AN DECAMARGO, EP AGROINDUSTRIAL RURAL SETTLEMENT DASILVA, LP ANALYSIS OF GROWTH FROM TYPES AND PREISINGER, H FLORISTIC COMPOSITION OF THE COELHO, LF SPONTANEOUS VEGETATION IN AN INST ANGEW BOT SIQUEIRA, MD AGRICULTURAL TEST AREA NEAR MANAUS, LIEBEREI, R AMAZONAS, BRAZIL INFLUENCE OF DIFFERENT CROPPING SYSTEMS ON THE DENSITY OF DEOLIVEIRA, EP INST NACL PESQUISAS TERRESTRIAL INVERTEBRATES IN VARZEA SOIL OF CENTRAL AMAZONIA WHERES THE BEEF - INCORPORATING CATTLE INTO SUSTAINABLE MISSISSIPPI STATE LOKER, WM AGROFORESTRY SYSTEM SIN THE AMAZON UNIV BASIN

Em relação aos termos referentes ao tema defesa agropecuária, não foram localizados artigos que se referem a Amazônia em seu título.

3. TEMA: MUDANÇAS CLIMÁTICAS GLOBAIS

Apresentam-se a seguir os títulos dos 10 artigos que citam Amazônia no título, sobre o tema mudanças climáticas globais, com seus respectivos autores e instituições. Instituição de Título Autores correspondência Miles, L The impact of global climate change on tropical Grainger, A Univ Leeds forest biodiversity in Amazonia Phillips, O Weng, CY Holocene climate change and hydrarch Bush, MB Florida Inst Technol succession in lowland Amazonian Ecuador Athens, JS Positive feedbacks among forest fragmentation, Laurance, WF Smithsonian Trop Res Inst drought, and climate change in the Amazon Williamson, GB Amazon jungle linked to global warming [Anon] Late Quaternary vegetation and climate change in the Amazon basin based on a 50,000 year pollen Haberle, SG Monash Univ record from the Amazon fan, ODP site 932 A crisis in the making: responses of Amazonian Laurance, WF Natl Inst Res Amazon INPA forests to land use and climate change Amazonian deforestation and global warming: Carbon stocks in vegetation replacing Brazil's Fearnside, PM NATL INST RES AMAZON Amazon forest

Instituição de Título Autores correspondência DETECTING CLIMATE-CHANGE CONCURRENT WITH DEFORESTATION IN THE AMAZON BALLING, RC ARIZONA STATE UNIV BASIN - WHICH WAY HAS IT GONE – HUGHES, WS COMMENT DETECTING CLIMATE-CHANGE CONCURRENT HASTENRATH, WITH DEFORESTATION IN THE AMAZON UNIV HAWAII MANOA S BASIN - WHICH WAY HAS IT GONE – REPLY CHU, PS DETECTING CLIMATE-CHANGE CONCURRENT YU, ZP WITH DEFORESTATION IN THE AMAZON UNIV HAWAII HASTENRATH, BASIN - WHICH WAY HAS IT GONE S

Em relação aos termos referentes ao tema mudanças climáticas globais, não foram localizados artigos que se referem a Amazônia em seu título.

4. TEMA: PROGRAMAS DE DESCOBERTA

Em relação aos termos referentes ao tema programas de descoberta, em dois termos (clonagem e proteômica) foram localizados artigos que se referem em seu título à Amazônia. Os títulos dos artigos, seus autores e instituições são apresentados a seguir. a. Clonagem Instituição de Título Autores correspondência Lasakosvitsch, F Gentil, LG Cloning and characterisation of a cysteine dos Santos, proteinase gene expressed in amastigotes of Univ Fed Sao Paulo MRM Leishmania (L.) amazonensis da Silveira, JF Barbieri, CL Cloning and functional analysis of the Lye, LF ribonucleotide reductase gene small subunit from Hsieh, YH Acad Sinica hydroxyurea-resistant Leishmania mexicana Su, KE amazonensis Lee, ST

Leishmania mexicana amazonensis: Differential Heard, PL display analysis and cloning of mRNAs from Lewis, CS - attenuated and infective forms Chaudhuri, G

22 b. Proteômica Instituição de Título Autores correspondência Batista, CVF del Pozo, L Proteomics of the venom from the Amazonian Zamudio, FZ scorpion Tityus cambridgei and the role of prolines Contreras, S Natl Autonomous Univ Mexico on mass spectrometry analysis of toxins Becerril, B Wanke, E Possani, LD

II - Artigos relacionados com o Brasil A tabela a seguir mostra a freqüência de artigos que citam o Brasil no título e no resumo, para os temas e termos deste estudo. Relacionados ao TEMAS/ TERMOS DA BIOTECNOLOGIA Brasil TITÚLO RESUMO Tema: Biodiversidade/ Bioprospecção 19 181 Bancos de germoplasma 0 17 Herbários e demais formas de conservação ex 2 33 situ Legislação ágil e eficiente 1 4 Termos da Biodiversidade marinha 1 2 Biodiversidade/ Bioprospecção Acesso ao patrimônio Genético 0 3

Conhecimento tradicional 0 3 Mercado de produtos da floresta 0 8 Propriedade intelectual 0 3 Fitomedicamentos 2 25 Tema: Bioeconomia 1 3 Tema: Bioindústria 0 0 Termos da Bioprodutos 0 2 Bioindústria Tema: Bioinformática 0 2 Termos da Aplicações para Genomas, proteomas e 0 1 Bioinformática biodiversidade Tema: Biorremediação 2 14 Termos da Microorganismos 0 9 Biorremediação Tema: Bioterrorismo 0 1 Tema: Certificação de qualidade biológica 0 0 Termos da Coleções certificadas 0 1 Certificação de qualidade biológica Microorganismos 0 4 Tema: Defesa Agropecuária 254* 2123* Termos da Sistemas Efetivos de Monitoramento 1 68 Defesa Agropecuária Tema: Farmacogenética 0 5 Tema: Fertilidade e reprodução animal 0 3 Tema: Integração: alimentação, nutrição e saúde 0 40 Termos da Nutracêuticos (Alimentos Funcionais) 0 1 Integração: alimentação, nutrição e Produção de Vacinas em Plantas e Animais 1 44 saúde Tema: Metagenômica/ Prospecção Gênica 0 1 Tema: Mudanças climáticas globais 7 67 Tema: Programas de Descoberta n.a. n.a. Clonagem 5 106 Termos da Programas de Stem Cells 11 24 Descoberta Genômica Funcional 0 2 Engenharia Genética 0 11 Proteômica 0 6 Tema: Segurança Biológica 3 9 Termos da Segurança Biológica Níveis de segurança 0 2 Tema: Sustentabilidade Ambiental 0 3 Termos da Sustentabilidade OGMs 0 7 Ambiental Bioinseticidas 0 5 * Estes números se referem à artigos sobre agropecuária e Amazônia n.a. = não se aplica. O tema programas de descoberta não é um termo de busca.

Nos itens que se seguem são apresentados a classificação, os títulos, autores e instituição de correspondência dos artigos relacionados aos temas/termos deste estudo. A coluna de classificação organiza os resultados encontrados pelo foco observado no título. Utilizou-se a instituição de correspondência como referência do local de realização da pesquisa.

1. TEMA: BIODIVERSIDADE/BIOPROSPECÇÃO

Apresentam-se a seguir os títulos dos 19 artigos que citam Brasil no título, sobre o tema biodiversidade/bioprospecção, com seus respectivos autores e instituições. A análise dos títulos dos artigos mostra que, neste caso, a maioria dos artigos refere- se a aspectos gerais do Brasil, não estando focadas em uma área geográfica ou tipo de vegetação especificamente.

Instituição de Classificação Título Autores correspondência Luque, JL Parasite biodiversity and its determinants in Mouillot, D Univ Otago coastal marine teleost fishes of Brazil Poulin, R Barbosa, FAR Brazilian LTER: Ecosystem and biodiversity Scarano, FR Univ Fed Minas information in support of decision-making Sabara, MG Gerais Esteves, FA de Mendonca, A study on the valuing of biodiversity: the case MJC IPEA of three endangered species in Brazil Sachsida, A Loureiro, PRA Biodiversity under rocks: the role of Ferreira, RL Univ Fed Minas microhabitats in structuring invertebrate Silva, MS Gerais Geral communities in Brazilian outcrops Bird community as an indicator of biodiversity: Vielliard, JME UNICAMP results from quantitative surveys in Brazil Sustainable use of biodiversity - Components BarretodeCastro, MINIST CIENCIA of a model project for Brazil LA & TECNOL BRAZIL FIGHTS TO SAVE BIODIVERSITY ROCHA, J Brazil considers biodiversity legislation [Anon] Moreira, FMS Biodiversity of rhizobia isolated from a wide Haukka, K Univ York range of forest legumes in Brazil Young, JPW Plenary and invited lectures from the 2nd IUPAC International Conference on Braga, FC

Biodiversity, Belo Horizonte, Brazil, 11-15 de Oliveira, AB July 1999 - Preface Biodiversity and speciation in the south of Brazil and the basin of the Parana river: Romaniuc-Neto, Museum Natl Hist Sul do Brasil influences in the Sorocea A St-Hil (Moraceae) S Nat genus species complex

Instituição de Classificação Título Autores correspondência de Santa-Isabel, Biodiversity and spatial distribution of LM Peso-Aguiar, MC Bahia Polychaeta (Annelida) communities in coral- Univ Fed Bahia de Jesus, ACS algal buildup sediment, Bahia, Brazil Kelmo, F Dutra, LXC Biodiversity of Collembola in tropical Culik, MP agricultural environments of Espirito Santo, de Souza, JL Brazil (vol 21, pg 49, 2002) Ventura, JÁ Espírito Santo Biodiversity of Collembola in tropical Culik, MP agricultural environments of Espirito Santo, de Souza, JL Brazil Ventura, JÁ Biodiversity and dynamics of ichthyic Chaves, P Guaratuba communities in the mangrove of Guaratuba, Univ Fed Parana Bouchereau, JL Brazil Ratter, JA The Brazilian cerrado vegetation and threats to ROYAL BOT Cerrado Ribeiro, JF its biodiversity GARDENS Bridgewater, S Saving Brazil's Atlantic rainforest: Using the golden-headed lion tamarin Leontopithecus Durrell Wildlife Mallinson, JJC Floresta chrysomelas as a flagship for a biodiversity Conservat Trust Tropical hotspot Biodiversity of killer activity in yeasts isolated Buzzini, P Univ Perugia from the Brazilian rain forest Martini, A Marques, MI Arthropod biodiversity in the canopy of Adis, J Max Planck Inst Pantanal Vochysia divergens (Vochysiaceae), a forest da Cunha, CN Limnol dominant in the Brazilian Pantanal dos Santos, GB Pivello, VR Alien grasses in Brazilian savannas: a threat to Savana Shida, CN Univ Sao Paulo the biodiversity Meirelles, ST

Em relação aos termos referentes ao tema biodiversidade/bioprospecção, em cinco termos foram localizados artigos que se referem em seu título ao Brasil. A classificação, os títulos dos artigos, seus autores e instituições para cada termo, são apresentados a seguir. a. Herbários e demais formas de conservação ex situ

Instituição de Classificação Título Autores correspondência Junior, JFD Collecting, ex situ conservation and Bezerra, JEF characterization of ''caja-umbu'' Embrapa Coastal PE Lederman, IE (Spondias mombin x Spondias tuberosa) Tablelands Alves, MA germplasm in Pernambuco State, Brazil Neto, MLD Geral Count F. C. Raben's Brazilian herbaria Ryding, O Bot Museum & Lib

26 b. Legislação ágil e eficiente

Instituição de Classificação Título Autores correspondência Geral Brazil considers biodiversity legislation [Anon]

c. Biodiversidade marinha Instituição de Classificação Título Autores correspondência Luque, JL Parasite biodiversity and its determinants in Geral Mouillot, D Univ Otago coastal marine teleost fishes of Brazil Poulin, R

d. Fitomedicamentos Instituição de Classificação Título Autores correspondência Pharmaceutics and phytotherapics: The need for Yunes, RA Univ Fed Santa development of the industry of Pedrosa, RC Catarina phytopharmaceutics and phytotherapics in Brazil Cechinel, V Geral Comparison between ethnopharmacology in traditional Chinese medicine and Brazilian popular Botsaris, AS _ phytotherapy

2. TEMA: BIOECONOMIA Apresentam-se a seguir o título do artigo que cita Brasil no título, sobre o tema bioeconomia, com seu respectivo autor e Instituição de correspondência. Instituição de Classificação Título Autores correspondência Bioeconomic analysis of breeding season de Abreu, UGP Embrapa Região Central introduction in roductive systems of beef herd Cezar, IM Pantanal in Brazil Central Region Torres, RDA

Em relação aos termos referentes ao tema bioeconomia, não foram localizados artigos que se referem ao Brasil em seu título.

3. TEMA: BIORREMEDIAÇÃO Apresentam-se a seguir os títulos dos 2 artigos que citam Brasil no título, sobre o tema biorremediação, com seus respectivos autores e instituições. Instituição de Classificação Título Autores correspondência Natural bioremediation perspective for BTX- UNIV FED Corseuil, HX contaminated groundwater in Brazil: Effect of SANTA Alvarez, PJJ Geral ethanol CATARINA Corseuil, HX Implications of the presence of ethanol on intrinsic Aires, JR bioremediation of BTX plumes in Brazil Alvarez, PJJ

Em relação aos termos referentes ao tema biorremediação, não foram localizados artigos que se referem ao Brasil em seu título.

4. TEMA: DEFESA AGROPECUÁRIA

Não foram localizados artigos que tratem especificamente de defesa agropecuária no Brasil. No entanto foram identificados 254 artigos relacionados com agropecuária no Brasil. Apresentam-se a seguir os títulos dos 100 primeiros artigos com seus respectivos autores e instituição de correspondência. A primeira coluna apresenta a abordagem geográfica ou de vegetação observada no título do artigo. Instituição de Classificação Título Autores correspondên cia Peixoto, PV Mota, RA Spontaneous BRSV infection in cattle of the Brito, MF Univ Fed Rural AL state of Alagoas, Brazil. Corbellini, LG Rio de Janeiro Driemeier, D de Souza, MI Muggler, CC Pedological characteristics of agricultural Curi, N Univ Fed BA environments at Corrente river tablelands, Silva, MLN Vicosa southwest of Bahia State, Brazil deLima, JM Gondim, LFP Serological survey of antibodies to Toxoplasma Barbosa, HV BA gondii in goats, sheep, cattle and water Univ Fed Bahia Ribeiro, CHA buffaloes in Bahia State, Brazil Saeki, H Gondim, LFP Seroprevalence of Neospora caninum in dairy Sartor, IF BA Univ Fed Bahia cattle in Bahia, Brazil Hasegawa, M Yamane, I Minist Belém Urban agriculture in Belem, Brazil Madaleno, I Cienciaeda Tecnol Perez-Escamilla, An adapted version of the US department of R Segall-Correa, agriculture food insecurity module is a valid AM Maranha, LK Univ Campinas tool for assessing household food insecurity in Sampaio, MDA Connecticut Campinas, Brazil Marin-Leon, L Panigassi, G Lardy, LC Carbon and phosphorus stocks of clayey Brossard, M Cerrado Ferralsols in Cerrado native and IRD Assad, MLL agroecosystems, Brazil Laurent, JY BIANCHIN, I EFFECT OF STOCKING RATES AND HONER, MR ANTHELMINTIC TREATMENTS ON WEIGHT NUNES, SG Cerrado GAINS IN WEANED NELLORE CATTLE ON CNPGC DO IMPROVED PASTURE IN THE BRAZILIAN NASCIMENTO, CERRADO YA EVOLUTION PATTERNS OF THE SOIL NASCIMENTO, ORGANIC-MATTER IN SOME VM UNIV ESTAD Cerrado AGRICULTURAL SYSTEMS IN THE ALMENDROS, G PAULISTA BRAZILIAN CERRADO REGION FERNANDES, FM

Instituição de Classificação Título Autores correspondên cia COMMISSION-VII WORKSHOP ON CROP Curitiba FORECASTING - MAY 11, 1993, CURITIBA, DACUHNA, RP BRAZIL Amabile, RF Severity of alternaria in sunflower crop in the DF Vasconcelos, CM CPAC Cerrado region of Federal District, Brazil Gomes, AC Biodiversity of Collembola in tropical Culik, MP Rua Elpidio ES agricultural environments of Espirito Santo, de Souza, JL Pimentel 383- Brazil Ventura, JA 302 Biodiversity of Collembola in tropical Culik, MP Rua Elpidio ES agricultural environments of Espirito Santo, de Souza, JL Pimentel 383- Brazil (vol 21, pg 49, 2002) Ventura, JA 302 Efficacy of Actara((R)) 25WG on three species Delgarde, S ES of Brazilian termite (Isoptera, Nasutitermitinae) Rouland-Lefevre, Univ Paris 12 crop pests C Factors influencing the adoption of sustainable De Souza, HM Univ ES agricultural technologies - Evidence from the Young, T Manchester state of Espirito Santo, Brazil Burton, MP Dobereiner, J "Cara inchada" of cattle, an infectious, Dutra, IS Geral apparently soil antibiotics-dependant UFRRJ Rosa, IV periodontitis in Brazil Blobel, H Franco, AC Spilki, FR A Brazilian glycoprotein E-negative bovine Esteves, PA herpesvirus type 1.2a (BHV-1.2a) mutant is de Lima, M Caixa Postal Geral attenuated for cattle and induces protection Weiblen, R 2076 against wild-type virus challenge Flores, EF Rijsewijk, FAM Roehe, PM Marques, F Geral A more pleasant future for Brazilian agriculture Esteves, B A new species of Agroiconota Spaeth from FED UNIV Geral Buzzi, ZJ Brazil (Coleoptera: Chrysomelidae, Cassidinae) PARANA Grassmann, B Adherence and experimental infection of Dobereiner, J Geral bacteria associated with periodontal infections Dutra, IS Univ Giessen of young cattle in Brazil ("Cara inchada") Kopp, PA Blobel, H Marcondes, CR Adjustment factors for weaning weight Eler, JP Geral according to age of dam in Nellore cattle in Univ Sao Paulo Ferraz, JBS Brazil Silva, PR Torres, RDA Bergmann, JAG Adjustment for heterogeneity of variance for Costa, CN Geral milk yield among herds of Holstein cattle in Pereira, CS UFV Brazil Valente, J Penna, VM Torres, RDA Aggregate distribution and soil organic matter Pinheiro, EFM under different tillage systems Geral Pereira, MG for vegetable crops in a Red Anjos, LHC Latosol from Brazil Agricultural biotech - Monsanto clears hurdle Geral Sissell, K in Brazil

Instituição de Classificação Título Autores correspondên cia Agricultural development with rainforest Tomich, TP conservation: Methods for seeking van Noordwijk, M Geral ICRAF SE Asia best bet alternatives to slash-and-burn, with Vosti, SA applications to Brazil and Indonesia Witcover, J Agricultural extension models in South America: A description of systems Arboleya, J Geral in use in Argentina, Brazil, Paraguay and Restaino, E Uruguay Leal, CV Montes, BA Mesa, AC Agrobacterium tumefaciens-mediated Geral Rua, AL CIB transformation of Paracoccidioides brasiliensis Corredor, M Restrepo, A McEwen, JG Allelopathic effects of legume cover crops on Casini, P Geral Univ Florence cogon grass (Imperata brasiliensis Trin.) Olivero, L Cardoso, IM Analysis of phosphorus by (PNMR)-P-31 in Van der Meer, P Univ Geral Oxisols under agroforestry and conventional Oenema, O Wageningen & coffee systems in Brazil Janssen, BH Res Ctr Kuyper, TW ANTIMICROBIAL DRUG- RESISTANCE IN PEREIRA, MSV Geral STAPHYLOCOCCUS-AUREUS SIQUEIRAJUNIO ISOLATED FROM CATTLE IN R, JP BRAZIL de Oliveira, SS Antimicrobial substances produced by Povoa, DC Staphylococcus aureus strains isolated from Nascimento, JD Univ Fed Rio de Geral cattle in Brazil Pereira, ND Janeiro de Siqueira, JP Bastos, MDD Streit, LG Association of the Brazil nut protein gene and Beach, LR Kunitz trypsin inhibitor Geral Register, JC Iowa State Univ alleles with soybean protease inhibitor activity Jung, R and agronomic traits Fehr, WR Fundacao Avermectin resistance of the cattle tick Martins, JR Estadual Geral Boophilus microplus in Brazil Furlong, J Pesquisa Agropecuaria Driemeier, D Baccharis megapotamica var weirii poisoning in Univ Fed Rio Geral Cruz, C Brazilian cattle Grande Sul Loretti, A Baccharis megapotamica var Weirii poisoning in Geral Loretti, AP Brazilian cattle (vol 42, pg 220, 2000) Bayesian inference for genetic parameter Magnabosco, CD Rua T36 Q154 Geral estimation on growth traits for Nelore cattle in Lobo, RB Lt 04 Apto 202 Brazil, using the Gibbs sampler Famula, TR Residencial Ortolani, EL Brito, LAB Botulism outbreak associated with poultry litter Mori, CS Geral Univ Sao Paulo consumption in three Brazilian cattle herds Schalch, U Pacheco, J Baldacci, L

Instituição de Classificação Título Autores correspondên cia Dutra, IS Dobereiner, J Botulism outbreaks in cattle in Brazil Geral Rosa, IV UNESP associated with contaminated water Souza, LAA Nonato, MW Geral Brazil - No cause for alarm at large crop Anon Capalbo, DMF Hilbeck, A Andow, D Snow, A Bong, BB Brazil and the development of international Wan, FH Embrapa Geral scientific biosafety testing guidelines for Fontes, EMG Environm transgenic crops Osir, EO Fitt, GP Johnston, J Songa, J Heong, KL Birch, ANE Brazil delays vote on bill to allow planting of Geral Anon GM crops Geral Brazil destroys AgrEvo transgenic rice crop Anon Geral Brazil halts Monsanto's genetic crops program Anon Geral Brazil nixes Monsanto soybean crop Anon Geral Brazil suspends ban on GM crops Sissell, K Rodrigues, AC Brazilian isolates of Trypanosoma Campaner, M (Megatrypanum) theileri: diagnosis and Takata, CSA Geral differentiation of isolates from cattle and water Dell'Porto, A Univ Sao Paulo buffalo based on biological characteristics and Milder, R randomly amplified DNA sequences Takeda, GF Teixeira, MMG Geral Brazilian sugarcane crop revised upwards Anon Lobato, FCF Mora, E Cattle and rabbits immune response against Umehara, O Geral beta and epsilon Clostridium perfringens toxins UFMG Assis, RA induced by six commercial vaccines in Brazil Martins, NE Goncalves, LCB Changing patterns of state intervention in the State Univ Geral Belik, W Brazilian agro-industrial complex Campinas Bernoux, M Volkoff, B CO2 emissions from liming of agricultural soils Ctr Energia Geral da Conceicao, M in Brazil Nucl Agr Carvalho, S Cerri, CC Coffee, one of the most exemplary agricultural Grandjean, P Geral Univ Reims products of Brazil Tulet, JC Sugayama, RL Colonization of a new fruit crop by Anastrepha Kovaleski, A Geral fraterculus (Diptera : Tephritidae) in Brazil: a Univ Sao Paulo Liedo, P demographic analysis Malavasi, A DEFARIA, RT COMPARISON OF THE VERSATILE SOIL- MADRAMOOTOO Inst Agron Geral MOISTURE BUDGET AND SWACROP , CA BOISVERT, Parana MODELS FOR A WHEAT CROP IN BRAZIL J PRASHER, SO

Instituição de Classificação Título Autores correspondên cia Conservation in Brazil's chocolate forest: The Geral unlikely persistence of the traditional cocoa Johns, ND Univ Texas agroecosystem Conservation-with-development models in Geral Brannstrom, C Univ London Brazil's agro-pastoral landscapes Controlling labor commitment in Brazil's global Geral Chase, J agriculture: the crisis of competing flexibilities Pena, HFD Geral Cryptosporidium muris in dairy cattle in Brazil Kasai, N Univ Sao Paulo Gennari, SM Cytogenetic and molecular biomonitoring of D'Arce, LPG Univ Estadual Geral agricultural workers exposed to pesticides in Colus, IMD Londrina Brazil Primavesi, O Frighetto, RTS Dos Santos Dairy cattle enteric methane measured in Geral Pedreira, M de EMBRAPA Brazilian tropical conditions Lima, MA Berchielli, TT Barbosa, PF Braz, CJ Development of an ELISA system for detection Ribeiro, MFB Geral of anti-Anaplasma marginale antibodies in UFMG Lima, JD cattle in Brazil Passos, LMF Diet of the maned wolf (Chrysocyon Santos, EF R Mistre Tito 42 Geral brachyurus) and its role in seed dispersal on a Setz, EZF Vila Ind cattle ranch in Brazil Gobbi, N Diffusion of sustainable agriculture in the Caviglia, JL Salisbury State Geral Brazilian tropical rain forest: A discrete choice Kahn, JR Univ analysis da Mota, AF Distribution of bovine lymphocyte antigen Gabriel, JE Geral (BOLA-DRB3) alleles in Brazilian dairy Gir USP Martinez, ML cattle (Bos indicus) Coutinho, LL Cardoso, IM Distribution of mycorrhizal fungal spores in soils Boddington, C Univ Geral under agroforestry and monocultural coffee Janssen, BH Wageningen & systems in Brazil Oenema, O Res Ctr Kuyper, TW Geral Drought affecting crop in Brazil ... Anon Montoro, P Teinseree, N Effect of exogenous calcium on Agrobacterium Rattana, W Geral tumefaciens-mediated gene transfer in Hevea Kasetsart Univ Kongsawadworak brasiliensis (rubber tree) friable calli ul, P Michaux- Ferriere, N Rodriguez, M Effect of vaccination with a recombinant Bm86 Massard, CL CTR INGN antigen preparation on natural infestations of daFonseca, AH Geral Ramos, NF GENET & Boophilus microplus in grazing dairy and beef Machado, H BIOTECNOL pure and cross bred cattle in Brazil Labarta, V delaFuente, J Effects of liming and legume/cereal cropping Andrade, DS Univ Geral on populations of indigenous rhizobia in an acid Murphy, PJ Wageningen & Brazilian Oxisol Giller, KE Res Ctr

Instituição de Classificação Título Autores correspondên cia Emerging views on translation history in Brazil Shaanxi Univ Geral Xu, JZ (CROP special issue) Sci & Technol Cappelle, ER Estimates of the intake and weight gain of Valadares, SD Geral cattle at Brazilian Conditions da Silva, JFC Cecon, PR Ethnic hegemony: the Japanese Brazilians in Geral Makabe, T RR4 agriculture, 1908-1968 Madruga, CR Marques, APC Araujo, FR Evaluation of an ELISA for detection of Miguita, M antibodies to Babesia bigemina in cattle and it's Embrapa Gado Geral Carvalho, CME application in an epidemiological survey in Corte Araujo, FS Brazil Umaki, ACS Crocci, AJ Queiroz, RA Evaluation of crop-water production functions de Faria, RT Inst Agron Geral for wheat (Triticum aestivum L.) in Brazil Madramootoo, CA Parana Evaluation of the average comparison tests in dos Santos, JW Ctr Nacl Geral the "Pesquisa Agropecuaria Brasileira" journal Moreira, JDAN Pesquisa from 1980 to 1994 Beltrao, NEDM Algodao Coutinho, HLC Evaluation of the diversity of rhizobia in Oliveira, VM Geral Brazilian agricultural soils cultivated with Lovato, A Embrapa Solos soybeans Maia, AHN Manfio, GP Evaluation of zinc, manganese and iron levels Embrapa Ctr Geral in liver samples of cattle and sheep from Moraes, SD Nacl Pesquisa various regions of Brazil. Gado Corte Ceron-Munoz, MF Factors that cause genotype by environment Tonhati, H Costa, interaction and use of a multiple-trait herd- Geral CN Rojas- Univ Anioquia cluster model for milk yield of Holstein cattle Sarmiento, D from Brazil and Colombia Echeverri, DME Neto, MH Generic trend for milk yield in Holstein cattle in Geral Silva, HM MINIST AGR Brazil and in the United States of America Bergmann, JAG Costa, CN Blake, RW Genetic analysis of Holstein cattle populations Pollak, EJ Embrapa Gada Geral in Brazil and the United States Oltenacu, PA Leite Quaas, RL Searle, SR Renno, FP de Araujo, CV Pereira, JC Genetic and phenotypic correlations among De Freitas, MS Geral type traits and milk yield of brown Swiss cattle UFV Torres, RD in Brazil Renno, LN Azeveddo, JAG Kaiser, FD Ribeiro, PMT Genetic parameters and inbreeding levels in Geral Ferraz, JBS Univ Sao Paulo Santa Gertrudis cattle in Brazil Eler, JP

Instituição de Classificação Título Autores correspondên cia GENETIC-PARAMETERS FOR MILK-YIELD FREITAS, AF Geral AND COMPOSITION OF CROSSBRED WILCOX, CJ DAIRY-CATTLE IN BRAZIL ROMAN, RM Genotyping BoLA-DRB3 alleles in Brazilian da Mota, AF Dairy Gir cattle (Bos indicus) by temperature- Geral Martinez, ML Univ Sao Paulo gradient gel electrophoresis (TGGE) and direct Coutinho, LL sequencing Geral Growth surges in 1998/94 Brazilian crop cycle Anon de Araujo, CV Torres, RD Renno, FP Heterogeneity of variance and genetic Pereira, JC Geral evaluation of Brown Swiss cattle breed in UFV Torres, RD Brazil. Araujo, SI Pires, AV Rodrigues, CAF Torres, RD Bergmann, JAG Costa, CN Heterogeneity of variance and genetic Pereira, CS Geral evaluation of Holstein cattle in Brazil Valente, J Penna, VM Torres, RD de Araujo, CV Hunting spiders of woodland fragments and Rinaldi, IMP Forti, Geral agricultural habitats in the Atlantic rain forest UNESP LC region of Brazil Improving nutrient use efficiency of annual Natl Rice & Fageria, NK Geral crops in Brazilian acid soils for sustainable Bean Res Ctr Baligar, VC crop production Embrapa de Queiroz, SA de Inbreeding effects on growth traits of Gyr cattle Geral Albuquerque, LG UNESP in Brazil Lanzoni, NA Langoni, H de Souza, LC Incidence of leptospiral abortion in Brazilian da Silva, AV Geral dairy cattle Luvizotto, MCR Paes, AC Lucheis, SB Di Mauro, AO Interactions in the Agrobacterium-soybean de Nobrega, JCM Geral system and capability of some Brazilian UNESP Di Mauro, SMZ soybean cultivars to produce somatic embryos Collins, GB Interest groups and economic policy: Explaining Univ Calif Geral the pattern of protection in the Brazilian Helfand, SM Riverside agricultural sector INTERROOT MOVEMENT OF AZOSPIRILLUM-BRASILENSE AND BASHAN, Y Geral SUBSEQUENT ROOT COLONIZATION OF BIOL RES CTR HOLGUIN, G CROP AND WEED SEEDLINGS GROWING IN SOIL ISOLATION AND CHARACTERIZATION OF A LOCUS FROM AZOSPIRILLUM-BRASILENSE RAINA, S SP7 THAT COMPLEMENTS THE RAINA, R Geral TUMORIGENIC DEFECT OF VENKATESH, TV AGROBACTERIUM-TUMEFACIENS CHVB DAS, HK MUTANT

Instituição de Classificação Título Autores correspondên cia Marcal, WS Gaste, L Lead concentration in mineral salt mixtures Liboni, M Londrina State Geral used in beef cattle food supplementation in Pardo, PE Univ Brazil Do Nascimento, MR Hisasi, CS Traverso, SD Loretti, AP Geral Lead poisoning in cattle in southern Brazil UFRGS Donini, MA Driemeier, D Litter decomposition in semideciduous forest Louzada, JNC Geral and Eucalyptus spp. crop in Brazil: A Schoereder, JH comparison DeMarco, P Balota, EL Long-term tillage and crop rotation effects on Colozzi, A Geral microbial biomass and C and N mineralization IAPAR Andrade, DS in a Brazilian Oxisol Dick, RP Basanta, MV Dourado-Neto, D Reichardt, K Bacchi, OOS Oliveira, JCM Management effects on nitrogen recovery in a Trivelin, PCO Geral Univ Sao Paulo sugarcane crop grown in Brazil Timm, LC Tominaga, TT Correchel, V Cassaro, FAM Pires, LF de Macedo, JR Managing urban settlement in Brazil's UNIV CALIF Geral Chase, J agroindustrial frontier LOS ANGELES Moraes, SD Microelement deficiencies and imbalances in Geral Tokarnia, CH EMBRAPA cattle and sheep in some regions of Brazil Dobereiner, J Milk protein polymorphisms in Brazilian Zebu da Silva, IT Univ Fed Sao Geral cattle Del Lama, MA Carlos Tokarnia, CH Mineral deficiencies and imbalances in cattle Dobereiner, J Univ Fed Rural Geral and sheep - a review of Brazilian studies made Moraes, SS Rio de Janeiro between 1987 and 1998 Peixoto, PV da Silva, FF Valadares, SD Itavo, LCV Net and dietary energy, protein and Veloso, CM Geral macrominerals requirements of beef cattle in UESB Valadares, RFD Brazil Cecon, PR Paulino, PVR de Moraes, EHBK Networks and agricultural development: The de Sousa, ISF Brazilian Corp Geral case of soybean production and consumption in Busch, L Agr Res Brazil OCCURRENCE OF AGROBACTERIUM- DEOLIVEIRA, JR Univ Fed Geral TUMEFACIENS BIOVAR 3 ON GRAPEVINE IN ROMEIRO, RD Vicosa BRAZIL LACERDA, BDL PCR screening and allele frequency estimation Ribeiro, LA Baron, EE Geral of bovine leukocyte adhesion deficiency in Martinez, ML USP Holstein and Gir cattle in Brazil Coutinho, LL

Instituição de Classificação Título Autores correspondên cia Persistence of polycyclic aromatic hydrocarbons Geral in the soil of a burned area for agricultural purposes in Brazil Dasgupta, S Pesticide use in Brazil in the era of Geral Mamingi, N World Bank agroindustrialization and globalization Meisner, C Pereira, MSV Phage-mediated transfer of tetracycline Barreto, VP Univ Fed Geral resistance in Staphylococcus aureus isolated Siqueira-Junior, Paraiba from cattle in Brazil JP UNIV FED Photosensitization and crystal-associated Lemos, RA MATO Geral cholangiohepatopathy in cattle grazing Salvador, SC GROSSO DO Brachiaria decumbens in Brazil Nakazato, L SUL Plant biotech - European consumers stunt Geral Sissell, K Brazilian crops Miretti, MM Predominant African-derived mtDNA in Dunner, S Wellcome Trust Geral Caribbean and Brazilian Creole cattle is also Naves, M Sanger Inst found in Spanish cattle (Bos taurus) Contel, EP Ferro, JA Duarte, ER Prevalence of Malassezia spp. in the ears of Melo, MM Geral asymptomatic cattle and cattle with otitis in UFMG Hahn, RC Brazil Hamdan, JS Producing possession: labour, law and land on Geral Brannstrom, C Univ London a Brazilian agricultural frontier, 1920-1945 Montoro, P Rattana, W Production of Hevea brasiliensis transgenic Pujade-Renaud, V Geral embryogenic callus lines by Agrobacterium Michaux-Ferriere, N CIRAD CP tumefaciens: roles of calcium Monkolsook, Y Kanthapura, R Adunsadthapong, S Remineralization for sustainable agriculture: A Leonardos, OH Geral Theodoro, SH UNB tropical perspective from a Brazilian viewpoint Assad, ML Meas, S Ruas, FJ Usui, T Seroprevalence and molecular evidence for the Teraoka, Y Mulenga, A Geral presence of bovine immunodeficiency virus in Hokkaido Univ Chang, KS Brazilian cattle Masuda, A Madruga, CR Ohashi, K Onuma, M Skin test and tick immune status in susceptible Bechara, GH Univ Estadual Geral Morelli, J and resistant cattle in Brazil Szabo, MPJ Paulista Smoke impacts from agricultural burning in a Reinhardt, TE Geral Ottmar, RD URS Corp rural Brazilian town Castilla, C Neves, CSVJ Soil bulk density and porosity of homogeneous Feller, C Guimaraes, MF Londrina State Geral morphological units identified by the Cropping Medina, CC Univ Profile Method in clayey Oxisols in Brazil Tavares, J Fortier, M

Instituição de Classificação Título Autores correspondên cia Soil tillage and precision agriculture - A Sparovek, G Inst Plant Nutr Geral theoretical case study for soil erosion control in Schnug, E & Soil Sci Brazilian sugar cane production Soil-atmosphere CO exchanges and microbial King, GM Hungria, Geral biogeochemistry of CO transformations in a Univ Maine M Brazilian agricultural ecosystem Benyei, B Superovulatory response in continuously heat Fari, M Geral stressed Holstein-Friesian cattle in Brazil Barros, CWC Solti, L DROSTE, A SUSCEPTIBILITY OF BRAZILIAN SOYBEAN BODANESEZANE Geral CULTIVARS TO AGROBACTERIUM- TTINI, MH TUMEFACIENS MUNDSTOCK, E HU, CY MAURO, AO SUSCEPTIBILITY OF SOME BRAZILIAN NOBREGA, JC UNIV ESTADO Geral SOYBEAN GENOTYPES TO 3 STRAINS OF BARALDI, GL SAO PAULO AGROBACTERIUM-TUMEFACIENS COLLINS, GB Systemic granulomatous disease in Brazilian Fighera, RA Univ Fed Santa Geral cattle grazing pasture containing vetch (Vicia Barros, CS Maria spp) TAXATION OF AGRICULTURE IN BRAZIL - Geral HELFAND, S DO LOBBIES MATTER Chueire, LMO Taxonomic classification of rhizobial strains Bangel, EV recommended for soybean and common bean Mostasso, FL Geral Embrapa Soja crops in Brazil based on the sequencing of the Campo, RJ 16s rRNA gene Pedrosa, FO Hungria, M The Brazilian cattle sector: Status, prospects Geral Faminow, MD Univ Manitoba and controversies The distribution of subsidized agricultural Univ Calif Geral Helfand, SM credit in Brazil: Do interest groups matter? Riverside The impact of sector-specific and economy- Helfand, SM de Univ Calif Geral wide policy reforms on the agricultural sector Rezende, GC Riverside in Brazil: 1980-98 Lira, WM The incidence of Shiga toxin-producing Geral Macedo, C Univ Sao Paulo Escherichia coli in cattle with mastitis in Brazil Marin, JM Sparovek, G Cooper, M Dourado-Neto, D Maule, RF The land resource information and suitability Vidal-Torrado, P Geral system for family agriculture (LARISSA), Pimenta, LFD Univ Sao Paulo developed for the Brazilian agrarian reform Martins, SP Teramoto, ER Silva, AC Van de Steeg, J Schnug, E The political economy of agricultural policy in Univ Calif Geral Brazil: Decision Making and Influence from Helfand, SM Riverside 1964 to 1992 Total costs, environmental standards and Grote, U Zentrum international competitiveness - Case study results for Geral Deblitz, C Entwicklungsfor selected agricultural products from Brazil, Germany and Indonesia Stegmann, S ch

Instituição de Classificação Título Autores correspondên cia Trace elements in Brazilian agricultural Gabe, U Geral USP limestones and mineral fertilizers Rodella, AA Use of Gliricidia sepium and Leucaena Barreto, AC Geral leucocephala in alley cropping systems to EMBRAPA Fernandes, MF improve Brazilian coastal tableland soils Farias, PRS Sanchez-Vila, X Using geostatistical analysis to evaluate the Barbosa, JC Geral presence of Rotylenchulus reniformis in cotton Dept Sci Vieira, SR crops in Brazil: Economic implications Ferraz, LCCB Soliz-Delfin, J Marques, LFA Variance components and genetic parameters Pereira, JCC Univ Fed Geral estimates for growth traits of Simmental cattle Oliveira, HN Fluminense in Brazil Pereira, CS Bergmann, JAG Marchiori, CH Vieira, CIS Muscoid dipterous insects associated with Caldas, ER GO cattle feces and their parasitoids in Goias ULBRA Teixeira, FF State, Brazil Silva, CG Linhares, AX Regional prestige: Cooperatives and Calif State Univ GO agroindustrial identity in southwest Goias, Chase, J Los Angeles; Brazil Species of Spalangia (Hymenoptera : Marchiori, CH Pteromalidae : Spalangiane) as parasitoid pupa GO Oliveira, AT ULBRA of muscoid dipterous insects in cattle feces in Linhares, AX Goias State, Brazil Trapped workers, urban freedoms and labor Univ GO control in Brazilian agriculture: Evidence from Chase, J Massachusetts southwest Goias CROP-ROTATION IN GUARAPUAVA, PR BRAZIL .16. ENERGETIC EFFICIENCY OF DOSSANTOS, HP Guarapuava EMBRAPA ROTATION SYSTEMS FOR WHEAT, UNDER REIS, EM NO-TILLAGE Marchiori, CH Inst Luterano Muscoid dipterous collected from cattle dung Caldas, ER Itumbiara Ensino Superior pats in pastures in Itumbiara, Goias, Brazil Almeida, KGS Itumbiara Linhares, AX Influence of weather and plant cutting on aphid deCarvalho, AR population (Homoptera: Aphididae) in alfalfa UNIV FED Lavras Bueno, VHP crop (Medicago sativa L) in Lavras county, LAVRAS Mendes, S Brazil Dube, F A simulation model for evaluating technical and Couto, L economic aspects of an industrial eucalyptus- Silva, ML MG QMI based agroforestry system in Minas Gerais, Leite, HG Brazil Garcia, R Araujo, GAA COUTO, L CATTLE AND SHEEP IN EUCALYPT ROATH, RL Univ Fed MG PLANTATIONS - A SILVOPASTORAL BETTERS, DR Vicosa ALTERNATIVE IN MINAS-GERAIS, BRAZIL GARCIA, R ALMEIDA, JCC

Instituição de Classificação Título Autores correspondên cia Cardoso, IM Guijt, Continual learning for agroforestry system Univ I Franco, FS MG design: university, NGO and farmer partnership Wageningen & Carvalho, AF in Minas Gerais, Brazil Res Ctr Neto, PSF EVALUATION OF AGRONOMIC PERFORMANCE AND FIBER QUALITY OF PENNA, JCV Univ Fed MG CULTIVARS AND STRAINS OF GLANDLESS TORRES, GA Uberlandia COTTON GROWN IN THE CONDITIONS OF MINAS-GERAIS, BRAZIL Factors limiting the growth of Panicum de Andrade, CMS maximum cv. Tanzania-1 in an Univ Fed MG Garcia, R Couto, L agrosilvopastoral system with eucalypt, in the Vicosa Pereira, OG Cerrados of Minas Gerais, Brazil Growth and yield of coffee plants in MG agroforestry and monoculture systems in Minas Gerais, Brazil Infection by Neospora caninum associated with de Melo, CB Leite, Univ Fed MG bovine herpesvirus 1 and bovine viral diarrhea RC Lobato, ZIP Sergipe virus in cattle from Minas Gerais State, Brazil Leite, RC Seasonal infection pattern of gastrointestinal Univ Fed Minas MG nematodes of beef cattle in Minas Gerais State Lima, WS Gerais Brazil Seasonal variation of Boophilus microplus Lima, WS Ribeiro, Univ Fed Minas MG (Canestrini, 1887) (Acari : Ixodidae) in cattle in MF Guimaraes, Gerais Minas Gerais state, Brazil MP "The law of the least effort" - Cattle ranching No Kentucky MT and the environment in the savanna of Mato Wilcox, RW Univ Grosso, Brazil, 1900-1980 Effect of cropping systems on the stability of MT red-yellow latosol aggregates in Querencia, Correa, JC EMBRAPA Mato Grosso, Brazil Ferreira, VCP Genotype environmental interaction in some Penna, VM MT UFMG growth traits of beef cattle in Brazil Bergmann, JAG Torres, RA Santos, SA Costa, Univ Estadual Botanical composition of cattle diet on C Souza, GDE Pantanal Paulista Julio rangelands in the Pantanal wetland, Brazil Pott, A Alvarez, Mesquita Filho JM Machado, SR Cattle ranching and deforestation in the Seidl, AF de Silva, Colorado State Pantanal Brazilian Pantanal JDV Moraes, AS Univ DEALMEIDA, IL CATTLE REPRODUCTIVE-PERFORMANCE DEBRUM, PAR IN THE PAIAGUAS SUBREGION OF THE Pantanal TULLIO, RR EMBRAPA BRAZILIAN PANTANAL .4. EFFECT OF CALF AROEIRA, JADC WEANING AGE ON BREEDING COWS POTT, EB Dynamics of Haematobia irritans irritans Embrapa Pantanal (Diptera : Muscidae) infestation on Nelore cattle Barros, ATM Pantanal in the Pantanal, Brazil INVESTIGATIONS ON NATURALLY- OCCURRING TRYPANOSOMA-EVANSI FRANKE, CR INFECTIONS IN HORSES, CATTLE, DOGS Pantanal GREINER, M AND CAPYBARAS (HYDROCHAERIS- MEHLITZ, D HYDROCHAERIS) IN PANTANAL-DE- POCONE (MATO-GROSSO, BRAZIL)

Instituição de Classificação Título Autores correspondên cia dosSantos, HP Crop productivity of wheat rotation systems for Passo Fundo Ignaczak, JC EMBRAPA ten-year period, in Passo Fundo, RS, Brazil Lhamby, JCB ZAFFARONI, E AGROCLIMATIC POTENTIAL OF SILVA, MAV Univ Fed PB SUNFLOWER IN PARAIBA STATE, BRAZIL DE AZEVEDO, Pelotas .1. TEMPERATURE AND SOLAR-RADIATION PV ZAFFARONI, E AGROCLIMATIC POTENTIAL OF SILVA, MAV Univ Fed PB SUNFLOWER IN PARAIBA STATE, BRAZIL DE AZEVEDO, Pelotas .2. WATER REQUIREMENTS PV Morphological dimorphism in the Y Britto, CMC PI chromosome of "pe-duro" cattle in the Brazilian UNICAMP Mello, MLS State of Piaui SUSCEPTIBILITY OF THE 2-SPOTTED DESOUZA, MF SPIDER-MITE COLLECTED FROM GRAPE SUPLICY, N Pilar-do-Sul INST BIOL CROP (VITIS SPP) IN PILAR-DO-SUL, SAO- SATO, ME PAULO, BRAZIL, TO SOME ACARICIDES TAKEMATSU, AP Determination of spatial water requirements at Heinemann, AB county and regional levels using crop models PR Hoogenboom, G Univ Georgia and GIS - An example for the State of Parana, de Faria, RT Brazil Effects of pruning season on cassava crops in Inst Agron PR Takahashi, M the Northwestern region of Parana, Brazil Parana Luz, E Experimental infection of Lymnaea columella, Carlos, L Physa cubensis and Physa marmorata with Diniz, JMF PR UF PR cattle Fasciola hepatica miracidia from Curitiba Leite, LC urban area and Parana East Coast, Brazil Kozemjakin, DA Werka, L de Azevedo, JR Mannigel, RC Agulhon, AZ Prevalence and geographical distribution of Borba, TR PR bovine eurytrematosis in cattle slaughtered in CESUMAR Barbieri, AW northern Parana, Brazil de Oliveira, DCL Headley, SA Janeiro, V Guimaraes, JS Prevalence of Neospora caninum antibodies Souza, SLP Univ Estadual PR and factors associated with their presence in Bergamaschi, DP Londrina dairy cattle of the north of Parana' state, Brazil Gennari, SM de Souza, SLP Guimaraes, JS Prevalence of Neospora caninum antibodies in PR Ferreira, F USDA ARS dogs from dairy cattle farms in Parana, Brazil Dubey, JP Gennari, SM Vidotto, MC Vidotto, O Seroprevalenee of Anaplasma marginale in Andrade, GM Univ Estadual PR cattle in Parana State, Brazil, by MSP-5 Palmer, G Londrina competitive ELISA McElwain, T Knowles, DP Carbon and nitrogen mineralization in soils Kanda, K Natl Inst Região under agro-pastoral systems in subtropical Miranda, CHB Agroenvironm Central Central Brazil Macedo, MCM Sci

Instituição de Classificação Título Autores correspondên cia Affholder, F Diagnosis of the productivity gap using a crop Região Scopel, E model. Methodology and case study of small- Cirad CA Central Neto, JM scale maize production in central Brazil Capillon, A THE BRAZILIAN MIDWEST - ECONOMIC Região AND SOCIOGEOGRAPHIC CHANGE IN A INNSBRUCK BORSDORF, A Centro-Oeste PERIPHERAL AGRICULTURAL REGION - UNIV GERMAN - COY,M, LUCKER,R INDIGENOUS KNOWLEDGE IN A MODERN SCHULZ, B Região Leste SUSTAINABLE AGROFORESTRY SYSTEM – BECKER, B A CASE-STUDY FROM EASTERN BRAZIL GOTSCH, E de Carvalho, HWL Leal, MDD Adaptability and yield stability of corn cultivars Cardoso, MJ Região dos Santos, MX in the Brazilian Northeast in the agricultural EMBRAPA Nordeste de Carvalho, BCL year of 1998 Tabosa, JN Lira, MA Albuquerque, MM Effects on employment, wages, and labor Região standards of non-traditional export crops in Damiani, O Nordeste northeast Brazil Fine root mineralization, soil organic matter and Lessa, ASN Região exchangeable cation dynamics in slash and Univ Anderson, DW Nordeste burn agriculture in the semi-arid northeast of Saskatchewan Moir, JO Brazil Lima, M Univ London Região Influence of heavy agricultural work during Ismail, S London Sch Nordeste pregnancy on birthweight in Northeast Brazil Ashworth, A Hyg & Trop Morris, SS Med Modeling soil nutrient limitations to crop de Barros, I Região production in semiarid NE of Brazil with a Williams, JR Ctr CIRAD Nordeste modified EPIC version I. Changes in the source Gaiser, T code of the model Tiessen, H Região Organic matter turnover and management in Univ Sampaio, EVSB Nordeste low input agriculture of NE Brazil Saskatchewan Salcedo, IH Sampaio, ESB Residual N and P fertilizer effect and fertilizer Região Tiessen, H Univ Fed recovery on intercropped and sole-cropped Nordeste Antonino, ACD Pernambuco corn and bean in semiarid northeast Brazil Salcedo, IH A study of alley-cropping data from Northern Oyejola, BA IACR Região Norte Brazil - II. A comparison of methods to estimate Riley, J Rothamsted sample size Bolton, S Região A survey of dairy cattle worm control practices Charles, TP EMBRAPA Sudeste in Southeast Brazil Furlong, J Cattle dung breeding diptera in pastures in Região Mendes, J Univ Estadual southeastern Brazil: Diversity, abundance and Sudeste Linhares, AX Campinas seasonality Gomes, LI Rocha, MA Costa, EA Região Detection of bovine herpesvirus type 5 (BoHV- Lobato, ZIP Univ Fed Minas Mendes, LCN Sudeste 5) in cattle in Southeast Brazil Borges, AS Gerais Leite, RC Barbosa-Stancioli, EF

Instituição de Classificação Título Autores correspondên cia Optimal replacement and insemination policies Cardoso, VL Região for Holstein cattle in the southeastern region of Nogueira, JR Van Inst Zootecnia; Sudeste Brazil: The effect of selling animals for Arendonk, JAM production Cardoso, VL Optimum replacement and insemination policies Região Nogueira, JR Wageningen for crossbred cattle (Holstein Friesian x Zebu) Sudeste Van Arendonk, Univ Agr in the south-east region of Brazil JAM Corbellini, LG Pescador, CA Abortus by Aspergillus fumigatus and Frantz, FJ de Região Sul UFRGS Aspergillus niger in cattle in southern Brazil Lima, M Ferreiro, L Driemeier, D Gava, A Neves, DD Bracken fern (Pteridium aquilinum) poisoning in Gava,DSaliba,TD Univ Estado Região Sul cattle in southern Brazil Schild, AL Riet- Santa Catarina Correa, F Loretti, AP Clinical and pathological study of an outbreak of de Oliveira, LO Univ Fed Rio Região Sul obstructive urolithiasis in feedlot cattle in Cruz, CEF Grande Sul southern Brazil Driemeier, D Schild, AL Riet-Correa, F Congenital cerebellar cortical degeneration in Região Sul Portiansky, EL UFPel Holstein cattle in southern Brazil Mendez, MC Graca, DL Busscher, WJ Reeves, DW Kochhann, RA Conservation farming in southern Brazil: Using Bauer, PJ Região Sul cover crops to decrease erosion and increase Mullins, GL infiltration Clapham, WM Kemper, WD Galerani, PR CONTESTING THE HOUSEHOLD ESTATE - Região Sul SOUTHERN BRAZILIAN PEASANTS AND CRAVIOTTI, C MODERN AGRICULTURE - PAPMA,F CONTESTING THE HOUSEHOLD ESTATE, INST SOCIAL Região Sul SOUTHERN BRAZILIAN PEASANTS AND KAY, C STUDIES MODERN AGRICULTURE - PAPMA,F Passos, DT Detection of genomic variability in different Ferreira, CAS Univ Fed Rio Região Sul populations of the cattle tick Boophilus da Silva, SS Grande Sul microplus in southern Brazil Richter, MF Ozaki, LS Sanches, AWD Diseases of the central nervous system in Langohr, IM Região Sul UFSM cattle of southern Brazil. Stigger, AL Barros, CSL Giacomini, SJ Aita, C Dry matter, C/N ratio and nitrogen, phosphorus Vendruscolo, ERO Univ Fed Santa Região Sul and potassium accumulation in mixed soil cover Cubilla, M Maria crops in Southern Brazil Nicoloso, RS Fries, MR

Instituição de Classificação Título Autores correspondên cia DOS SANTOS, EFFECT OF CROP-ROTATION ON YIELDS, HP ZENTNER, SOIL CHEMICAL CHARACTERISTICS, AND Região Sul RP EMBRAPA ECONOMIC RETURNS OF ZERO-TILL SELLES, F BARLEY IN SOUTHERN BRAZIL AMBROSI, I Effect of no-till cropping systems on soil Bayer, C Embrapa organic matter in a sandy clay loam Acrisol from Martin-Neto, L Região Sul Instrumentacao Southern Brazil monitored by electron spin Mielniczuk, J Agropecuaria resonance and nuclear magnetic resonance Ceretta, CA Field observations of Ateleia glazioviana Gava, A Univ Fed Santa Região Sul poisoning in cattle in southern Brazil de Barros, CSL Catarina Gaining ground: Land use and soil conservation Região Sul in areas of agricultural colonisation in South Morris, AS Univ Glasgow Brazil and East Paraguay Genetic parameters for agronomic traits of Oettler, G Univ Região Sul triticale and other small-grain cereals grown on Wietholter, S Hohenheim aluminium-toxic soil in southern Brazil Horst, WJ Hyperthermic syndrome in dairy cattle Ilha, MRS Região Sul associated with consumption of ergots of Loretti, AP Claviceps purpurea in southern Brazil Barros, CSL Mendez, MD Intoxication by Xanthium cavanillesii in cattle Univ Fed Região Sul dos Santos, RC and sheep in southern Brazil Pelotas Riet-Correa, F Long-term tillage and crop rotation effects on DeMaria, IC Região Sul soil chemical properties of a Rhodic Ferralsol in Nnabude, PC Inst Agron southern Brazil de Castro, OM Nitrogen availability as affected by ten years of Amado, TJC Univ Fed Rio Região Sul cover crop and tillage systems in southern Fernandez, SB Grande Sul Brazil Mielniczuk, J Bayer, C Organic matter storage in a sandy clay loam Mielniczuk, J Região Sul Acrisol affected by tillage and cropping Amado, TJC systems in southern Brazil Martin-Neto, L Fernandes, SV Torres, MB Redroot pigweed (Amaranthus retroflexus) Kommers, GD Univ Fed Santa Região Sul poisoning of cattle in southern Brazil Dantas, AFM Maria deBarros, CSL Locatelli-Dittrich, R Soccol, VT Serological diagnosis of neosporosis in a herd Richartz, RRTB Univ Fed Região Sul of dairy cattle in southern Brazil Gasino-Joineau, ME Parana Vinne, R Pinckney, RD Moreira, CN Shiga toxin-producing Escherichia coli (STEC) Pereira, MA Brod, CS Região Sul isolated from healthy dairy cattle in southern UFPel Rodrigues, DP Brazil Carvalhal, JB Aleixo, JAG Freixo, AA Soil organic carbon and fractions of a Rhodic Machado, PLOD Região Sul Ferralsol under the influence of tillage and crop dos Santos, HP Embrapa Solos rotation systems in southern Brazil Silva, CA Fadigas, FD The Je of southern Brazil and the antiquity of Região Sul agriculture: Linguistic, archaeological and Noelli, FS ethnographic elements

Instituição de Classificação Título Autores correspondên cia Damaso, CRA An emergent poxvirus from humans and cattle Esposito, JJ RJ in Rio de Janeiro State: Cantagalo virus may UFRJ Condit, RC derive from Brazilian smallpox vaccine Moussatche, N Meyer, A Cancer mortality among agricultural workers Chrisman, J Escola Nacl RJ from Serrana Region, state of Rio de Janeiro, Moreira, JC Saude Publica Brazil Koifman, S Cerqueira, AMF High occurrence of Shiga toxin-producing Guth, BEC Univ Fed RJ Escherichia coli (STEC) in healthy cattle in Rio Joaquim, RM Fluminense de janeiro State, Brazil Andrade, JRC Deforestation and agroforestry adoption in tropical forests: Can we generalize? Some Casey, JF RO results from Campeche, Mexico, and Rondonia, Caviglia, JL Brazil. Kirkman, GA Gut, A Surface exchange of nitric oxide, nitrogen Ammann, C Gatti, LV Max Planck Inst RO dioxide, and ozone at a cattle pasture in Cordova, AM Chem Rondonia, Brazil Moura, MAL Andreae, MO Meixner, FX Sustainable agricultural practices in Rondonia, RO Brazil: Do local farmer organizations affect Caviglia-Harris, JL adoption rates? Driemeier, D Clinico-pathological aspects in the natural Gomes, MJP infection of Bovine Respiratory Syncytial Virus Moojen, V Univ Fed Rio RS Arns, CW (BRSV) in extensive management of cattle in Vogg, G Grande Sul Rio Grande do Sul, Brazil Kessler, L daCosta, UM Garmatz, SL Malignant catarrhal fever in cattle in Rio Grande Irigoyen, LE do Sul, Brazil: Experimental transmission to Rech, RR RS cattle and characterization of the etiological Brown, CC agent. Zhang, J Barros, CSL Corbellini, LG Driemeier, D Neosporosis as a cause of abortion in dairy Univ Fed Rio RS Cruz, CFE cattle in Rio Grande do Sul, southern Brazil Grande Sul Gondim, LFP Wald, V Martins, JR Partial strategic tick control within a herd of Estrada Evans, DE RS European breed cattle in the state of Rio Bandeirantes Cereser, VH Grande do Sul, southern Brazil 27635 Correa, BL Driemeier, D Spontaneous poisoning by the burs of Xanthium Irigoyen, LF Univ Fed Rio RS cavanillesii (Asteraceae) in cattle in Rio Grande Loretti, AP Grande Sul do Sul, southern Brazil Colodel, EM Barros, CSL Barros, CSL Systemic granulomatous disease in cattle in Rio Fighera, RA Rozza, DB Univ Fed Santa RS Grande do Sul, Brazil, associated with grazing Rech, RR Maria vetch (Vicia spp) Sallis, SV Langohr, IM

Instituição de Classificação Título Autores correspondên cia Time of agricultural use and chemical properties of two Ferralsols in the Planalto Perin, E RS Ceretta, CA EMATER PR Medio region of the State of Rio Grande do Sul, Klamt, E Brazil Soil and climate characteristics and socio- Escola Super economic data in the diagnostic of Pinto, LFG São Carlos Agr Luis agroecosystems of Sao Carlos region, SP, Crestana, S Dequeiroz Brazil Primavesi, O Water quality of the Canchim's creek watershed de Freitas, AR São Carlos in Sao Carlos, SP, Brazil, occupied by beef and EMBRAPA Primavesi, AC dairy cattle activities de Oliveira, HT Teixeira, DL Agronomic characterization of amaranth for Savana Spehar, CR QE 21 cultivation in the Brazilian Savannah Souza, LAC IMPACT OF STRATEGIC GENES IN CERRADOS SOYBEAN ON AGRICULTURAL- Savana SPEHAR, CR NATL RES DEVELOPMENT IN THE BRAZILIAN CTR TROPICAL SAVANNAS Gava, A Sousa, RS Phalaris angusta (Gramineae) causing de Deus, MS Univ Estado SC neurological disease in cattle in the State of Pilati, C Santa Catarina Santa Catarina, Brazil Cristani, J Mori, A Neves, DS Selection of indigenous rhizobia to the cowpea, Fernandes, MF SE pigeonpea and jackbean crops in the coastal Fernandes, RPM EMBRAPA tableland of Sergipe, Brazil Hungria, M Cullen, L Agroforestry benefit zones: A tool for the Schmink, M SP conservation and management of Atlantic forest Padua, CV fragments, Sao Paulo, Brazil Morato, MIR CARBON STORAGE AND OTHER LEPSCH, IF PROPERTIES OF SOILS UNDER INST AGRON SP MENK, JRF AGRICULTURE AND NATURAL VEGETATION CAMPINAS OLIVEIRA, JB IN SAO-PAULO STATE, BRAZIL Buzinaro, MG Electrophoretical characterization and subgroup Munford, V SP analysis of rotavirus in dairy cattle in the State Brito, VMED UNESP of Sao Paulo, Brazil. Racz, ML Jerez, JA Enhanced degradation of metalaxyl in Papini, S Ctr Protecao SP agricultural soils of Sao Paulo State, Brazil de Andrea, MM Ambiental Amarante, AFT Host specificity of sheep and cattle nematodes Bagnola, J Univ Estadual SP in Sao Paulo state, Brazil Amarante, MRV Paulista Barbosa, MA Oppenheimer, C Tsanev, VI Allen, AG NO2 emissions from agricultural burning in McGonigle, AJS SP Univ Cambridge Sao Paulo, Brazil Cardoso, AA Wiatr, A Paterlini, W De Mello, C

Instituição de Classificação Título Autores correspondên cia Occurrence of cattle Sarcocystis species in raw Pena, HFD kibbe from Arabian food establishments in the SP Ogassawara, S Univ Sao Paulo city of Sao Paulo, Brazil, and experimental Sinhorini, IL transmission to humans da Rocha, GO Sources of atmospheric acidity in an Franco, A SP agricultural-industrial region of Sao Paulo UNESP Allen, AG State, Brazil Cardoso, AA de Castro, VL Evaluation of family agriculture health: the Embrapa Meio Sumaré da Silveira, MA Sumare case – Brazil Ambiente Perez, MA Ferraz, PB Ramos, AD Genetic trends of the direct and maternal effects da Silva, LOC Tabapuã for weaning and post-weaning weights of UFMS de Souza, JC de Tabapua cattle in Brazil Alencar, MM Malhado, CHM Vercesi, AE Population structure of the registered Tabapua Faria, FJC Tabapuã UFMG cattle in Brazil Madalena, FE Josahkian, LA Effect of agroindustrial wastes on the Zanetti, AL Univ Fed Uberlândia mycelium growth of Pleurotus sp ''Florida'', in Ranal, MA Uberlandia Uberlandia, Brazil Santos, PG Evaluation of the agronomic performance of Juliatti, FC Univ Fed Uberlândia corn hybrids in Uberlandia, MG, Brazil Buiatti, AL Uberlandia Hamawaki, OT MINERAL AND ORGANIC FERTILIZING ON DEFARIA, CMB Vale do São THE MELON CROP IN A VERTISOL OF THE PEREIRA, JR EMBRAPA Francisco SUBMIDDLE SAO-FRANCISCO VALLEY, DEPOSSIDEO, BRAZIL EL Saumell, CA Padilha, T Nematophagous fungi in fresh feces of cattle in Zona da Mata Santos, C ARS the Mata region of Minas Gerais state, Brazil de Roque, P de Roque, MVC

Em relação ao tema defesa agropecuária, apenas no termo Sistemas Efetivos de Monitoramento foi localizado um artigo que se refere em seu título ao Brasil, cujos autores e Instituição de correspondência são apresentados a seguir.

a. Sistemas Efetivos de Monitoramento

Instituição de Classificação Título Autores correspondência Effect of no-till cropping systems on soil Bayer, C organic matter in a sandy clay loam Acrisol Embrapa Martin-Neto, L Sul do Brasil from Southern Brazil monitored by electron Instrumentacao Mielniczuk, J spin resonance and nuclear magnetic Agropecuaria Ceretta, CA resonance

5. TEMA: INTEGRAÇÃO: ALIMENTAÇÃO, NUTRIÇÃO E SAÚDE

Para este tema não foram localizados artigos que citam explicitamente o Brasil no título. Dentre os termos relacionados ao tema, apenas no termo produção de vacinas foi localizado um artigo, cujo título, autor e Instituição de correspondência são apresentados a seguir. a. Produção de Vacinas em Plantas e Animais

Instituição de Classificação Título Autores correspondência Post, PR The early use of yellow fever virus strain 17D de Carvalho, R Geral Univ Fed Pelotas for vaccine production in Brazil - A review Freire, MD Galler, R

6. TEMA: MUDANÇAS CLIMÁTICAS GLOBAIS

Apresentam-se a seguir os títulos dos 7 artigos que citam Brasil no título, sobre o tema mudanças climáticas globais, com seus respectivos autores e instituições.

Instituição de Classificação Título Autores correspondência Martinelli, LA Pessenda, LCR Espinoza, E Carbon-13 variation with depth in soils of Camargo, PB CTR ENERGIA Brazil and climate change during the Telles, EC NUCL AGR quaternary Cerri, CC Victoria, RL Geral Aravena, R Richey, J Trumbore, S Ribeiro, SK Global warming and transport in Brazil - Younes- UFRJ ethanol alternative Ibrahim, PS Future electric power technology choices of Schaeffer, R Brazil: a possible conflict between local UFRJ Szklo, AS pollution and global climate change de Araujo, JC Doll, D Guntner, A Water scarcity under scenarios for global Região Krol, M climate change and regional development Nordeste Abreu, CBR in semiarid northeastern Brazil Hauschild, M Mendiondo, EM

Instituição de Classificação Título Autores correspondência Lutzomyia vectors for cutaneous Região leishmaniasis in Southern Brazil: ecological Peterson, AT Univ Kansas Sudeste niche models, predicted geographic Shaw, J distributions, and climate change effects Forests and global warming mitigation in Inst Nacl Brazil: opportunities in the Brazilian forest Fearnside, PM Pesquisas sector for responses to global warming Amazonia Floresta under the "clean development mechanism" Global warming response options in NATL INST RES Brazil's forest sector: Comparison of Fearnside, PM AMAZON project-level costs and benefits

Em relação aos termos referentes ao tema mudanças climáticas globais não foram localizados artigos que se referem ao Brasil em seu título.

7. TEMA: PROGRAMAS DE DESCOBERTA

Sobre este tema em dois termos – clonagem e células tronco - foram localizados artigos que referem-se em seu título ao Brasil. Os títulos dos artigos, seus autores e instituições são apresentados a seguir. a. Clonagem Instituição de Classificação Título Autores correspondência Cloning and characterization of the cDNA for the Brazilian Cratomorphus distinctus larval Viviani, VR Arnoldi, FGC Univ Estadual Sao Geral firefly luciferase: similarities with European Brochetto-Braga, M Paulo Lampyris noctiluca and Asiatic Pyrocoelia Ohmiya, Y luciferases Zurita, AI Rodriguez, J Cloning and characterization of the Leishmania Pinero, JE Geral (viannia) braziliensis Hsp70 gene. Diagnostic Pacheco, R Univ La Laguna use of the C-terminal fragment rLb70(513-663) Carmelo, E del Castillo, A Valladares, B Martinez, E Thomas, MC Cloning and molecular characterization of the Alonso, V Geral cDNA encoding histone H1 from Leishmania Carmelo, E Univ La Laguna braziliensis Gonzalez, AC Del Castillo, A Valladares, B Lewis, MJ Novoa, P Isolation, cloning, and complete nucleotide Ishak, R sequence of a phenotypically distinct Brazilian Ishak, M Natl Univ Ireland Univ Geral isolate of human T-lymphotropic virus type II Salemi, M Coll Dublin (HTLV-II) Vandamme, AM Kaplan, MH Hall, WW Viviani, VR Cloning and molecular characterization of the Silva, ACR Perez, GLO cDNA for the Brazilian larval click-beetle Geral Santelli, RV Harvard Univ Pyrearinus termitilluminans luciferase Bechara, EJH Reinach, FC

48 b. Stem Cells

Instituição de Classificação Título Autores correspond. De Souza, CA Ruiz, MA Vigorito, AC Aranha, FJP Zulli, R Miranda, ECM Dulley, FL Tabak, D Allogeneic haematopoietic stem cell transplantation - Azevedo, AM Geral EBMT risk score evaluation for 1084 CML patients - Byington, R transplanted in Brazil Azevedo, WM Silla, L Maiolino, A Nucci, M Voltarelli, JC Colturato, V De Souza, MP Pasquini, R Bonfim, CMS Bitencourt, MA Moreira, VA Setubal, DC Allogeneic stem cell transplantation for the treatment of Lorenzatto, C Geral 12 patients with Paroxysmal Nocturnal Hemoglobinuria in - Ruiz, J Brazil Neves, H de Medeiros, CR Zanis-Neto, J Pasquini, R Castro, CG Seber, A Mendes, W Castro, HC Autologous stem cell transplantation for the treatment of Borsato, ML Geral - pediatric solid tumors in Brazil Gregianin, LJ Ginani, VC Barros, JCA Petrilli, AS Brunetto, AL Voltarelli, J Hamerschlak, N Azevedo, W Massumoto, C Stracieri, A Brazilian cooperative trial of autologous hematopoietic Oliveira, M Geral stem cell transplantation for autoimmune diseases: - Ribeiro, A preliminary results Popovici, M Solmuci, C Vandausen, A Coutinho, M Paton, E Fagnani, R Dantas, SRPE Surveillance of tunneled catheters (Hickman) in Saboia, M Geral hematological stem cell transplant recipients at a Fortaleza, CMCB - University Hospital, Brazil Leichsering, M Carvalho, MCS Trabasso, P Trabasso, P Vigorito, A Invasive fungal infection in hematologic stem cell Geral De Souza, C - transplant recipients at a Brazilian University Hospital Branchini, M

Instituição de Classificação Título Autores correspond. Trabasso, P Attributable mortality due to invasive fungal infection Vigorito, A Geral among hematologic stem cell transplant recipients in a - De Souza, C Brazilian University Hospital Branchini, M Vasconcelos, ZFM Diamond, HR Pires, V Immunological study of the first cord blood stem cell Souza, MHO Geral transplantation at the Brazilian National Cancer Institute Barone, B - (INCA) Silva, MLM Tabak, DG Bouzas, LFS Rumjanek, VM Silva, RL Soussain, C Massumoto, C Macedo, MCA Medeiros, RSS Dzik, C Rocha, IF Autologous peripheral blood stem cells transplantation Silva, ACM Geral (APSBcT) as an outpatient basis. Experience of a - Loterio, HA Brazilian center. Diomede, BB Franca, GG Ostronoff, M Machado, CM DorlhiacLlacer, P Chamone, DAF Dulley, F Allogeneic peripheral blood stem cell versus bone Azevedo, WM marrow transplantation for chronic myeloid leukemia: A Fagundes, EM Região comparative study from State University of Campinas Lodi, FM - Sudeste (UNICAMP) and Federal University of Minas Gerais Vigorito, AC (UFMG), Brazil Souza, CA Lemos, MM Voltarelli, JC CD34+cells from bone marrow, peripheral blood stem Covas, DT Ribeirão Preto cell collection and umbilical cord blood: Quantitative - Zago, MA analysis at Hemocentro de Ribeirao Preto-USP-BRAZIL Palma, P Orellana, M

8. TEMA: SEGURANÇA BIOLÓGICA

Apresentam-se a seguir os títulos dos 3 artigos que citam Brasil no título, sobre o tema segurança biológica, com seus respectivos autores e instituições.

Instituição de Classificação Título Autores correspondência

Capalbo, DMF Hilbeck, A Andow, D Snow, A Bong, BB Brazil and the development of international Wan, FH Embrapa scientific biosafety testing guidelines for Fontes, EMG Environm transgenic crops Osir, EO Geral Fitt, GP Johnston, J Songa, J Heong, KL Birch, ANE

Globalization and Brazilian biosafety: the Univ Calif Los Jepson, WE politics of scale over biotechnology governance Angeles Brazil flexes biosafety muscle [Anon]

Em relação aos termos referentes ao tema segurança biológica não foram localizados artigos que se referem ao Brasil em seu título.

III - Artigos publicados por autores vinculados a instituições brasileiras

Esta seção trata dos artigos que tem pelo menos um autor vinculado a uma instituição brasileira. A tabela a seguir mostra a freqüência desses artigos com os temas/termos de busca no título e no resumo, para os temas e termos deste estudo. Autores de Instituições TEMAS/ TERMOS DA BIOTECNOLOGIA brasileiras TITULO RESUMO Tema: Biodiversidade/ Bioprospecção 42 238 Bancos de germoplasma 3 23 Herbários e demais formas de 6 34 conservação ex situ Legislação ágil e eficiente 0 2 Termos da Biodiversidade marinha 1 3 Biodiversidade/ Bioprospecção Acesso ao patrimônio Genético 0 2

Conhecimento tradicional 0 1 Mercado de produtos da floresta 0 23 Propriedade intelectual 0 2 Fitomedicamentos 9 45 Tema: Bioeconomia 2 4 Bioindústria 0 0 Termos da Bioprodutos 6 12 Bioindústria Tema: Bioinformática 10 39 Termos da Aplicações para Genomas, 0 1 Bioinformática proteomas e biodiversidade Tema: Biorremediação 4 44 Termos da Meio ambiente 1 15 Biorremediação Microorganismos 1 18

Tema: Bioterrorismo 0 2 Tema: Certificação de qualidade biológica 0 0 Termos da Certificação de Coleções certificadas 0 1 qualidade biológica Microorganismos 1 13 Tema: Defesa Agropecuária 1057* 3789*

Sistemas Efetivos de Termos da Defesa Agropecuária 2 126 Monitoramento

Tema: Farmacogenética 2 12 Tema: Fertilidade e reprodução animal 1 5 Termos da Fertilidade e Clonagem 0 1 Reprodução animal Tema: Integração: alimentação, nutrição e saúde 0 58 Nutracêuticos (Alimentos 4 13 Funcionais) Termos da Integração: Qualidade de vida 0 1 Alimentação, nutrição e saúde Bem estar 0 1

Produção de Vacinas em Plantas e 5 159 Animais Tema: Metagenômica/ Prospecção Gênica 0 1 Tema: Mudanças climáticas globais 29 140 Tema: Programas de Descoberta n.a. n.a.

Autores de Instituições TEMAS/ TERMOS DA BIOTECNOLOGIA brasileiras TITULO RESUMO Clonagem 159 822 Stem Cells 91 194 TERMOS da Genômica Funcional 1 12 Programas de Descoberta Farmacogenética 0 1

Engenharia Genética 1 20 Proteômica 12 28 Tema: Segurança Biológica 9 19 TERMOS da Níveis de segurança 0 1 Segurança Biológica Fluxo Gênico 0 1 Tema: Sustentabilidade Ambiental 0 1 OGMs 0 7 TERMOS da Sustentabilidade Bioinseticidas 4 15 Ambiental Biofungicidas 0 1 * Estes números se referem à artigos sobre agropecuária e Amazônia n.a. = não se aplica. O tema programas de descoberta não é um termo de busca.

Nas seções a seguir apresentam-se os títulos, autores e instituições relacionados a cada um dos temas/termos de busca. As instituições identificadas como brasileiras foram destacadas em negrito.

1. TEMA: BIODIVERSIDADE/BIOPROSPECÇÃO

Apresentam-se a seguir os títulos dos 42 artigos que tem pelo menos um autor vinculado a uma instituição brasileira, sobre o tema biodiversidade/bioprospecção, com seus respectivos autores e instituições.

Título Autores Instituiçôes Univ Fed Sao Carlos; A biodiversity approach in the neotropical Univ Rio Erythrinidae fish, Hoplias malabaricus. Bertollo, LAC Born, GG Dergam, JA Grande; Karyotypic survey, geographic distribution Fenocchio, AS Moreira, O Univ Fed of cytotypes and cytotaxonomic Vicosa; considerations Univ Nacl Misiones Smithsonian Trop Res Inst; Univ Ulm; A biodiversity assessment of bats Univ Tubingen; (Chiroptera) in a tropical lowland rainforest Sampaio, EM Kalko, EKV Bernard, E York Univ; of Central Amazonia, including Rodriguez-Herrera, B Handley, CO Costa Rica Natl methodological and conservation Museum; considerations Natl Museum Nat Hist; INPA IPEA; A study on the valuing of biodiversity: the de Mendonca, MJC Sachsida, A Univ Catol case of three endangered species in Brazil Loureiro, PRA Brasilia

Título Autores Instituiçôes UNIV LONDON WYE COLL; UNIV NAIROBI; Agricultural intensification, soil biodiversity Kahindi, JHP Woomer, P George, T UNESCO; and ecosystem function in the tropics: The Moreira, FMD Karanja, NK Giller, KE IRRI; role of nitrogen-fixing bacteria ESCUELA SUPER AGR LAVARAS Alien grasses in Brazilian savannas: a Pivello, VR Shida, CN Meirelles, ST Univ Sao Paulo threat to the biodiversity AMAZON BIODIVERSITY - A SEIDL, PR RENEWABLE NATURAL-RESOURCE Arthropod biodiversity in the canopy of Marques, MI Adis, J da Cunha, CN Fed Univ Mato Vochysia divergens (Vochysiaceae), a dos Santos, GB Grosso forest dominant in the Brazilian Pantanal Bioconnectivity: a blueprint for Gottlieb, OR Borin, MRDB FIOCRUZ biodiversity? Biodiversity - Seed germination in Univ Calif Davis; Bruna, EM rainforest fragments INPA Biodiversity and dynamics of ichthyic Univ Montpellier communities in the mangrove of Chaves, P Bouchereau, JL 2; Guaratuba, Brazil. Univ Fed Parana Biodiversity and ecosystem functioning in Univ Estado Ri Moulton, TP conservation of rivers and streams De Janeiro Biodiversity as an environmental service in Natl Inst Res Brazil's Amazonian forests: risks, value Fearnside, PM Amazon and conservation Univ Sao Paulo; US Forest Serv; Univ Basel; Univ Oxford; Res Inst Human Ozanne, CMP Anhuf, D Boulter, SL & Nat; Keller, M Kitching, RL Korner, C Japan Sci & Biodiversity meets the atmosphere: A Meinzer, FC Mitchell, AW Technol Corp; global view of forest canopies Nakashizuka, T Dias, PLS Stork, NE James Cook Univ Wright, SJ Yoshimura, M N Queensland; Smithsonian Trop Res Inst; Univ Surrey Roehampton; Griffith Univ Biodiversity of Collembola in tropical agricultural environments of Espirito Santo, Culik, MP de Souza, JL Ventura, JA INCAPER Brazil Biodiversity of Collembola in tropical Inst Capixaba agricultural environments of Espirito Santo, Culik, MP de Souza, JL Ventura, JA Pesquisa Brazil (vol 21, pg 49, 2002) Biodiversity of galling insects: historical, Univ Fed Minas community and habitat effects in four Goncalves-Alvim, SJ Fernandes, GW Gerais neotropical savannas Biodiversity under rocks: the role of Univ Fed Minas microhabitats in structuring invertebrate Ferreira, RL Silva, MS Gerais communities in Brazilian outcrops

Título Autores Instituiçôes

Biodiversity, epidemiology and virulence of Colletotrichum gloeosporioides. I. Genetic Kelemu, S Badel, JL Moreno, CX Ctr Int Agr Trop; and pathogenic diversity in Colletotrichum Miles, JW Chakraborty, S Fernandes, CSIRO Trop Agr; gloeosporioides isolates from Stylosanthes CD Charchar, MJD EMBRAPA guianensis

Biodiversity, epidemiology and virulence of CSIRO Trop Agr; Colletotrichum gloeosporioides. II. Genetic EMBRAPA; Chakraborty, S Perrott, R Charchar, and pathogenic diversity in isolates of Univ MJD Fernandes, CD Kelemu, S Colletotrichum gloeosporioides from eight Queensland; species of Stylosanthes CIAT Biodiversity, epidemiology and virulence of Colletotrichum gloeosporioides. III. Field Cameron, DF Charchar, MJD CSIRO Trop Agr; evaluation of Stylosanthes species for Fernandes, CD Kelemu, S EMBRAPA; anthracnose resistance in their centre of Chakraborty, S CIAT diversity

Biodiversity, epidemiology and virulence of Chakraborty, S Fernandes, CD CSIRO Trop Agr; Colletotrichum gloeosporioides. IV. Charchar, MJD Kelemu, S Cameron, EMBRAPA; Epidemiology of Stylosanthes anthracnose DF CIAT at the centre of host-pathogen diversity

Biodiversity: modelling angiosperms as Gottlieb, OR Borin, MRDB FIOCRUZ networks Univ Fed Santa Bioprospecting for plant and fungus Catarina; extracts with systemic effect to control the Stadnik, MJ Bettiol, W Saito, ML Lab Microbiol & cucumber powdery mildew Fitopatol Bird community as an indicator of biodiversity: results from quantitative Vielliard, JME UNICAMP surveys in Brazil Univ Fed Minas Brazilian LTER: Ecosystem and Gerais; Barbosa, FAR Scarano, FR Sabara, biodiversity information in support of Univ Fed Rio de MG Esteves, FA decision-making Janeiro; Unileste MG NATL HIST Ecological taxonomy: a basic tool for MUSEUM Barbosa, F Galdean, N biodiversity conservation GRIGORE ANTIPA Edward O. Wilson, doyen of biodiversity's Univ Estadual Oliveira, PS crusade, honorary fellow of ATB, 1999 Campinas ENABLING BIODIVERSITY VALLE, S EXPLORING SOLUTIONS FOR THE PERES, CA TROPICAL BIODIVERSITY CRISIS Fishes from the Paraiba do Sul River Univ Fed Rio de basin. Biodiversity and biogeographic Bizerril, CRSF Janeiro patterns FUTURE-ORIENTED MAPPING OF GOTTLIEB, OR BIODIVERSITY IN AMAZONIA Karyotypic studies on Hoplerythrinus unitaeniatus (Pisces, Erythrinidae) populations. Diniz, D Bertollo, LAC A biodiversity analysis Univ Otago; Parasite biodiversity and its determinants Univ Montpellier Luque, JL Mouillot, D Poulin, R in coastal marine teleost fishes of Brazil 2; Univ Fed Rural

Título Autores Instituiçôes Rio de Janeiro

Protecting indigenous peoples' rights to GOELDI Posey, DA biodiversity MUSEUM Rational design and biodiversity in the Oliva, G Univ Sao Paulo search for new antichagasic drugs Seed savers: Conserving agricultural Cordeiro, A biodiversity Self-organized criticality, optimization and Onody, RN De Castro, PA Univ Sao Paulo biodiversity Sustainable use of biodiversity - BarretodeCastro, LA Components of a model project for Brazil THE AMAZON RAIN-FOREST, SUSTAINABLE DEVELOPMENT AND UNIV BRASILIA; DORE, MHI NOGUEIRA, JM THE BIODIVERSITY CONVENTION - A BROCK UNIV POLITICAL-ECONOMY PERSPECTIVE The Brazilian cerrado vegetation and Ratter, JA Ribeiro, JF Bridgewater, S EMBRAPA threats to its biodiversity The relationship between fluvial morphology and biodiversity and its Fed Univ Rio De Bizerril, CRSF application in the process of environmental Janeiro evaluation. Univ Fed Minas Gerais; Mittermeier, RA Mittermeier, CG Conservat Int; Wilderness and biodiversity conservation Brooks, TM Pilgrim, JD Konstant, WR Int Wilderness da Fonseca, GAB Kormos, C Leadership WILD Fdn

Em relação aos termos referentes ao tema biodiversidade/bioprospecção, em quatro termos foram localizados artigos publicados por pelo menos um autor vinculado a instituição brasileira. Os títulos dos artigos, seus autores e instituições para cada termo, são apresentados a seguir. a. Bancos de germoplasma

Título Autores Instituição

Chromosome number and secondary constriction Guerra, M Pedrosa, A Silva, AEB variation in 51 accessions of a citrus germplasm Cornelio, MTM Santos, K Soares, bank WD

Genetic divergence among accessions of a Shimoya, A Cruz, CD Ferreira, RD Pesagro germplasm bank of elephantgrass Vander Pereira, A Carneiro, PCS Rio

Isozyme analysis of an active cassava germplasm Montarroyos, AVV de Lima, MAG IPA bank collection dos Santos, EO de Franca, JGE

b. Herbários e demais formas de conservação ex situ

Título Autores Instituições A list of type specimens of microfungi described by P. Hennings held at the Gusmao, LFP Baseia, IG Inst Bot Herbarium of Institute de Botanica (SP) Additions to Index Herbariorum (Herbaria), Holmgren, PK Holmgren, NH Univ Estado Edition 8 - Eleventh series Collecting, ex situ conservation and characterization of ''caja-umbu'' (Spondias Junior, JFD Bezerra, JEF IPA mombin x Spondias tuberosa) germplasm in Lederman, IE Alves, MA Neto, MLD Pernambuco State, Brazil Melastomataceae Raddianae: a study of G. Univ Fed Raddi's Melastomataceae types housed in Goldenberg, R Baldini, RM Parana; the herbaria of Pisa (PI) and Firenze (FI) Univ Florence Cincinnati Zoo & Bot Garden; Smithsonian Natl Zool Pk; Swanson, WF Johnson, WE Reproductive status of endemic felid species Univ Fed Parana; Cambre, RC Citino, SB Ouigley, KB White Oak in Latin American zoos and implications for ex Brousset, DM Morals, RN Moreira, Conservat Ctr; situ conservation N O'Brien, SJ Wildt, DE NCI; Hornocker Wildlife Res Inst; Univ Nacl Autonoma Mexico

Título Autores Instituições Inst Bot Darwinion; Reserva Ecol IBGE; Univ Nacl Filgueiras, TS Davidse, G Kirkbride, Autonoma Should small herbaria have voting rights? JH Chiang, F Rueda, R Zuloaga, Nicaragua; FO USDA ARS; Missouri Bot Gardens; Univ Nacl Autonoma Mexico

c. Biodiversidade marinha

Título Autores Instituição Univ Otago ; Parasite biodiversity and its determinants in coastal Luque, JL Mouillot, D Univ Fed Rural Rio de marine teleost fishes of Brazil Poulin, R Janeiro; Univ Montpellier 2

d. Fitomedicamentos

Título Autores Instituição Swiss Fed Inst Technol; Absence of genotoxicity of a phytotherapeutic extract de Sousa, NC de Fed Univ from Stryphnodendron adstringens (Mart.) Coville in Carvalho, S Spano, MA Goias; somatic and germ cells of Drosophila melanogaster Graf, U Univ Fed Uberlandia Univ Fed Analgesic effect of the herbal medicine Catuama in Vaz, ZR Mata, LV Calixto, Santa thermal and chemical models of nociception in mice JB Catarina Comparison between ethnopharmacology in traditional Botsaris, AS Chinese medicine and Brazilian popular phytotherapy Efficacy, safety, quality control, marketing and regulatory Univ Fed guidelines for herbal medicines (phytotherapeutic Calixto, JB Santa agents) Catarina Herbal medicine catuama induces endothelium- dependent and -independent vasorelaxant action on Calixto, JB Cabrini, DA isolated vessels from rats, guinea-pigs and rabbits Leishmaniasis phytotherapy. Nature's leadership against de Carvalho, PB Ferreira, Univ Sao an ancient disease EI Paulo Pesticide residues in medicinal plants and Univ Sao Zuin, VG Vilegas, JHY phytomedicines Paulo Univ Fed Pharmaceutics and phytotherapics: The need for Yunes, RA Pedrosa, RC Santa development of the industry of phytopharmaceutics and Cechinel, V Catarina; phytotherapics in Brazil. UNIVALI

Título Autores Instituição

Antunes, E Gordo, WM de The relaxation of isolated rabbit corpus cavernosum by Univ Estadual Oliveira, JF Teixeira, CE the herbal medicine Catuama (R) and its constituents Campinas Hyslop, S De Nucci, G

2. TEMA: BIOECONOMIA

Apresentam-se a seguir os títulos dos 2 artigos que tem pelo menos um autor vinculado a uma instituição brasileira, sobre o tema bioeconomia, com seus respectivos autores e instituições.

Título Autores Instituição Embrapa Pantanal; Bioeconomic analysis of breeding season introduction in de Abreu, UGP Cezar, Embrapa Gado productive systems of beef herd in Brazil Central Region IM Torres, RDA Corte; Univ Fed Vicosa de Castro, LAB Univ Sao Paulo; Sensitivity of the BEAM4 fisheries bioeconomic model to Petrere, M Comune, Univ Estadual the main biological input parameters AE Paulista

Em relação aos termos referentes ao tema bioeconomia, não foram localizados artigos publicados por autores vinculados a instituições brasileiras.

3. TEMA: BIOINDÚSTRIA

Não foram localizados artigos que contenham especificamente o tema Bioindústria no título. Em relação aos termos referentes ao tema bioindústria, em um termo (bioprodutos) foram localizados artigos publicados com pelo menos um autor vinculado a instituição brasileira. Os títulos dos 6 artigos, seus autores e instituições, são apresentados a seguir.

59 a. Bioprodutos

Título Autores Instituição Fontana, JD Czeczuga, B Bioproduction of carotenoids: The comparative MED ACAD; Bonfim, TMB Chociai, MB use of raw sugarcane juice and depolymerized UNIV FED Oliveira, BH Guimaraes, MF bagasse by Phaffia rhodozyma PARANA Baron, M Univ Fed Bioproduction of lichen phenolics by immobilized Blanco, Y Blanch, M Fontaniella, Pernambuco; lichen cells with emphasis on the role of B Legaz, ME Millanes, AM Univ epiphytic bacteria Pereira, EC Vicente, C Complutense Madrid BIOPRODUCTION OF USNIC ACID FROM PEREIRA, EC PEREYRA, T ACETATE BY KAOLINITE IMMOBILIZED MATOS, SC DASILVA, NH CELLS OF CLADONIA-SUBSTELLATA VAIN ANDRADE, L VICENTE, C Development of switched predictive control system for continuous purification process of Mattedi, A Maciel, R Sch Chem Engn bioproducts KiwiChem Int; Downstream processing of bioproducts Cockrem, M Santana, CC State Univ Campinas Influence of pH on the xylose reductase activity Fac Chem Engn Rodrigues, DCGD da Silva, SS of Candida guilliermondii during fed-batch xylitol Lorena; Vitolo, M bioproduction Univ Sao Paulo

4. TEMA: BIOINFORMÁTICA

Apresentam-se a seguir os títulos dos 10 artigos que tem pelo menos um autor vinculado a uma instituição brasileira no título, sobre o tema bioinformática, com seus respectivos autores e instituições.

Título Autores Instituição Analysis of structure and function of putative Childrens Hosp surface-exposed proteins encoded in the Oakland; Rigden, DJ Galperin, MY Streptococcus pneumoniae genome: A Cenargen Jedrzejas, MJ bioinformatics-based approach to vaccine and EMBRAPA; drug design Natl Lib Med State Univ Bioinformatics data analysis using an artificial Bezerra, GB de Castro, LN Campinas immune network Unicamp Telles, GP Braga, MDV Dias, Univ Estadual Bioinformatics of the sugarcane EST project Z Lin, TL Quitzau, JAA da Campinas Silva, FR Meidanis, J Comparative analysis of the catalytic domain of Ramos, OHP Selistre-de- Univ Fed Sao hemorrhagic and non-hemorrhagic snake venom Araujo, HS Carlos metallopeptidases using bioinformatic tools Scylla Current challenges in bioinformatics Meidanis, J Bioinformat; Univ Campinas Paquola, ACM Nishyiama, MY ESTWeb: bioinformatics services for EST Reis, EM da Silva, AM Univ Sao Paulo sequencing projects Verjovski-Almeida, S Special issue: Imaging in bioinformatics Costa, LD Belmonte, JCI Univ Sao Paulo;

Título Autores Instituição Salk Inst Biol Studies Structural bioinformatics study of cyclin- Canduri, F da Silveira, NJF Inst Butantan; dependent kinases complexed with inhibitors Camera, JC de Azevedo, WF UNESP UFRGS; Pereira, JH Canduri, F de Pontificia Univ Structural bioinformatics study of EPSP synthase Oliveira, JS da Silveira, NJF Catolica Rio from Mycobacterium tuberculosis Basso, LA Palma, MS de Grande Do Sul; Azevedo, WF Santos, DS Inst Butantan; UNESP da Silveira, NJF Uchoa, HB PUCRS; Canduri, F Pereira, JH Structural bioinformatics study of PNP from UFRGS; Camera, JC Basso, LA Palma, Schistosoma mansoni Inst Butantan; MS Santos, DS de Azevedo, UNESP WF

Em relação aos termos referentes ao tema bioinformática, não foram localizados artigos que contenham pelo menos um autor vinculado a uma instituição brasileira.

5. TEMA: BIORREMEDIAÇÃO

Apresentam-se a seguir os títulos dos 4 artigos que tem pelo menos um autor vinculado a uma instituição brasileira no título, sobre o tema biorremediação, com seus respectivos autores e instituições.

Título Autores Instituição Gomes, NCM Mendonca- Univ Fed Rio de Janeiro; Metal bioremediation by microorganisms Hagler, LCS Univ Ioannina Savvaidis, I Vidotti, EC Algae: From aquatic environment economy to Rollemberg, Univ Estadual Maringa bioremediation and analytical chemistry MDC Natural bioremediation of aquifer material Corseuil, HX contaminated with gasoline-ethanol mixtures Alvarez, PJJ Natural bioremediation perspective for BTX- Corseuil, HX contaminated groundwater in Brazil: Effect of UNIV IOWA Alvarez, PJJ ethanol

Em relação aos termos referentes ao tema biorremediação, em dois termos (Meio ambiente e Microorganismos) foram localizados artigos que têm pelo menos um autor vinculado a uma instituição brasileira no título. Os títulos dos artigos, seus autores e instituição de correspondência são apresentados a seguir.

a. Meio ambiente

Título Autores Instituição Vidotti, EC Algae: From aquatic environment economy to Rollemberg, Univ Estadual Maringa bioremediation and analytical chemistry MDC

b. Microorganismos

Título Autores Instituição Gomes, NCM Mendonca- Univ Fed Rio de Janeiro; Metal bioremediation by microorganisms Hagler, LCS Univ Ioannina Savvaidis, I

6. TEMA: CERTIFICAÇÃO DE QUALIDADE BIOLÓGICA

Em relação aos termos referentes ao tema Certificação de qualidade biológica, em um termo (Microorganismos) foi localizado 1 artigo que tem pelo menos um autor vinculado a uma instituição brasileira no título. O título do artigo, seus autores e instituição de correspondência são apresentados a seguir.

a. Microorganismos

Título Autores Instituição EMBRAPA Arroz Biological control of Phytophthora root rot of avocado with Costa, JLD Menge, & Feijao; microorganisms grown in organic mulches JA Casale, WL Univ Calif Riverside

7. TEMA: DEFESA AGROPECUÁRIA

Não foram localizados artigos que tratem especificamente de defesa agropecuária e tenham pelo menos um autor vinculado a uma instituição brasileira. No entanto foram identificados 1057 artigos relacionados com agropecuária que autores de instituição brasileira. Apresentam-se a seguir os títulos dos 100 primeiros artigos com seus respectivos autores e instituição de correspondência. Título Autores Instituição UFRRJ; A comparative study of the toxicity of de Oliveira, CMC Barbosa, JD Fed Univ Para; Palicourea juruana (Rubiaceae) to buffalo de Macedo, RSC Brito, MDF Univ Fed Rural Rio and cattle Peixoto, PV Tokarnia, CH Janeiro

Título Autores Instituição A practice analysis to account for adoption of innovations in irrigated rice cropping Ducrot, R Capillon, A CIRAD CA systems in Lake Alaotra (Madagascar) Oklahoma State Univ; Additive genetic relationships between Eler, JP Silva, JAIIV Evans, JL Agropecuaria CFM heifer pregnancy and scrotal Ferraz, JBS Dias, F Golden, Ltda; circumference in Nellore cattle BL Colorado State Univ; Univ Sao Paulo Agricultural and forest products as Inst Nacl de Pesquisas supplementary feeding for tambaqui in Guimaraes, SF Storti, A da Amazonia polyculture with jaraqui Agrobacterium tumefaciens-mediated dos Reis, MC Fungaro, MHP Univ Norte Parana; genetic transformation of the Duarte, RTD Furlaneto, L Univ Estadual entomopathogenic fungus Beauveria Furlaneto, MC Londrina bassiana Agrobacterium tumefaciens-mediated Molinari, HBC Bespalhok, JC Inst Agron Parana; transformation of Swingle citrumelo (Citrus Kobayashi, AK Pereira, LFP Embrapa Mandioca & paradisi Macf. x Poncirus trifoliata L. Raf.) Vieira, LGE Fruticultura using thin epicotyl sections Carvalho, CHS Zehr, UB Agrobacterium-mediated transformation of Embrapa Milho & Gunaratna, N Anderson, J sorghum: factors that affect transformation Sorgo; Kononowicz, HH Hodges, TK efficiency Purdue Univ Axtell, JD Agronomic and technologic characteristics Lemos, LB de Oliveira, RS of common bean genotypes from Carioca Univ Estado Sao Paulo Palomino, EC da Silva, TRB commercial group An adapted version of the US department Perez-Escamilla, R Segall- of agriculture food insecurity module is a Correa, AM Maranha, LK Univ Connecticut; valid tool for assessing household food Sampaio, MDA Marin-Leon, L Univ Campinas insecurity in Campinas, Brazil Panigassi, G Cerri, CEP Bernoux, A Assessment of soil property spatial Biol Marine Lab; Chaplot, V Volkoff, B Victoria, variation in an Amazon pasture: basis for Colorado State Univ; RL Melillo, JM Paustian, K selecting an agronomic experimental area Univ Sao Paulo Cerri, CC EMBRAPA; Beef cattle production and dry matter IAPAR; Assmann, AL Pelissari, A de accumulation in the crop-pasture rotation UFPR; Moraes, A Assmann, TS de system in presence and absence of white Ctr Fed Educ Tecnol; Oliveira, EB Sandini, I clover and nitrogen Fdn Educ Guarapuava PR Biological control of gastrointestinal trichostrongylids (Nematoda : Araujo, JV Assis, RCL Alves, Univ Fed Vicosa Trichostrongyloidea) of cattle by pellets of PH Campos, AK Gandra, JR Monacrosporium sinense] Cattle supplementation on Coastcross Prohmann, PEF Branco, AF pasture (Cynodon dactylon (L.) Pers) Jobim, CC Cecato, U Paris, W Univ Estadual Maringa during the summer Mouro, GF Cattle supplementation on Coastcross Prohmann, PEF Branco, AF pasture (Cynodon dactylon (L.) Pers) Cecato, U Jobim, CC UEM during the winter Guimaraes, KC Ferreira, RA Chemical interactions of Brachiaria Voll, E Franchini, JC Da Cruz, plantaginea with Commelina bengalensis RT Gazziero, DLP Brighenti, Embrapa Soybean and Acanthospermum hispidum in AM Adegas, FS soybean cropping systems Co)Variance components and genetic Cardoso, FF Cardellino, RA EMBRAPA; parameters of post-weaning traits in Angus Campos, LT UFPEL cattle Common bean lines with resistance to Pereira, HS dos Santos, JB Univ Fed Lavras anthracnose selected to desirable Abreu, ADB

Título Autores Instituição agronomical traits Comparative epidemiological, clinical and Tokarnia, CH Barbosa, JD de pathological aspects of poisoning by UFRRJ; Oliveira, CMC Brito, MDF de Arrabidaea bilabiata (Bignoniaceae) in Fed Univ Para Oliveira, RB Barbas, LAL buffalo and cattle. de Oliveira, RC Pires, AV Comparison of markers for estimating Fernandes, JJD Susin, I nutrient digestibility in high grain beef USP Santos, FAP Nascimento, VF cattle diets varying nitrogen sources de Araujo, RC UNESP; UNA; Comparison of selection criteria for pre- Pena, CDO Carvalheiro, R de GenSys Consultores weaning growth traits of Nelore cattle Queiroz, SA Fries, LA Associados SC Ltda; Lagoa Serra Ltda Corn crop residue decomposition and Bertol, I Leite, D Zoldan, WA UDESC related parameters Agr & Agri Food Cortisol in saliva and plasma of cattle after Negrao, JA Porcionato, MA de Canada; ACTH administration and milking Passille, AM Rushen, J Univ Sao Paulo UFLA; Cost analyses on different beef cattle Ferreira, IC Silva, MA Reis, RP EMBRAPA Gado Corte; genetic groups finished in feedlot condition Euclides, K Figueiredo, GR UFMG Univ Fed Santa Maria; Cover crop mixtures preceding no-till corn. Aita, C Giacomini, SJ Hubner, Empresa Pesquisa I-soil nitrogen dynamics AP Chiapinotto, IC Fries, MR Agropecuaria Extensao Rural Sant Univ Fed Santa Maria; Cover crop mixtures preceding no-till corn. Giacomini, SJ Aita, C Empresa Pesquisa II - Nitrogen accumulation by corn and Chiapinotto, IC Hubner, AP Agropecuaria & grain yield Marques, MG Cadore, F Extensao Rural Sa Crude protein levels in multiple Detmann, E Paulino, MF supplements for finishing crossbred beef Zervoudakis, JT Cecon, PR UNEF; cattle at pasture during dry season: Valadares, SD Goncalves, LC Univ Fed Mato Grosso Productive performance and carcass Cabral, LD Melo, AJN characteristics Crystallization and preliminary X-ray Lab Nacl Luz Alves, LR Oliveira, PL diffraction analysis of HeLp, a heme Sincrotron; Barbosa, JARG Guimaraes, lipoprotein from the hemolymph of the Univ Fed Rio de BG Medrano, FJ cattle tick Boophilus microplus Janeiro Cysteine-rich antimicrobial peptides of the Fogaca, AC Lorenzini, DM cattle tick Boophilus microplus: isolation, Univ Sao Paulo; Kaku, LM Esteves, E Bulet, P structural characterization and tissue CNRS Daffre, S expression profile Primavesi, O Frighetto, RTS Dairy cattle enteric methane measured in Dos Santos Pedreira, M de EMBRAPA; Brazilian tropical conditions Lima, MA Berchielli, TT Univ Estadual Paulista Barbosa, PF Deltamethrin impact in soil surface Coleoptera associated with maize crop in Araujo, RA Badji, CA Correa, Univ Fed Vicosa no tillage and conventional plantation AS Ladeira, JA Guedes, RNC systems Effect of age of exposure of heifers to Inst Zootecn Ribeirao reproduction on heritability Dias, LT El Faro, L Preto; estimates for age at first calving in Nelore Albuquerque, LG UNESP cattle Bergamaschi, MACM Vicente, Embrapa Pecuaria Effect of grazing system on fetal WRR Barbosa, RT Marques, Sudeste; development in Nellore cattle JA Freitas, AR UNESP

Título Autores Instituição Univ Estadual Paulista Effects of nitrogen and potassium Julio Mesquita Filho; Farinelli, R Penariol, FG fertilization on agronomic characteristics of Sementes Monsoy Fornasieri, D Bordin, L upland rice cultivated under no-tillage Monsanto; UNESP Entomopathogenic fungi selection to Fac Assis Guagacz; control Oligonychus yothersi (McGregor) De Oliveira, RC Neves, PMOJ UEL; (Acari : Tetranychidae) in Paraguay tea Alves, LFA UNIOESTE crops (Ilex paraguariensis St. Hill.) Evaluation of soil fertility in smallholder Alfaia, SS Ribeiro, GA Nobre, Inst Nacl de Pesquisas agroforestry systems and pastures in AD Luizao, RC Luizao, FJ da Amazonia western Amazonia Rosa, JRP da Silva, JHS Evaluation of the agronomic behavior of UFRGS; Restle, J Pascoal, LL the plant and nutritive value of silage from UFSM; Brondani, IL Alves, DC de different corn (Zea mays, L.) hybrids UFG Freitas, AK Cattani, CSDO Colodel, EM Experimental poisoning by Dodonea Univ Fed Rio Grande Traverso, SD Correa, AMR viscosa (Sapindaceae) in cattle Sul Driemeier, D Exploring the limits of crop productivity: Frantz, JM Ritchie, G Cometti, UFRRJ; Beyond the limits of tipburn in lettuce NN Robinson, J Bugbee, B Utah State Univ Factors that cause genotype by environment interaction and use of a Ceron-Munoz, MF Tonhati, H Univ Anioquia; multiple-trait herd-cluster model for milk Costa, CN Rojas-Sarmiento, D Embrapa Gado Leite; yield of Holstein cattle from Brazil and Echeverri, DME Univ Estadual Paulista Colombia EMBRAPA; Floristic inventory of secondary vegetation Baar, R Cordeiro, MD Denich, Ctr Dev Res; in agricultural systems of East-Amazonia M Folster, H Inst Soil Sci & Forest Nutr Genetic and phenotypic correlations Esteves, AMC Bergmann, JAG UFMG; between type traits and milk production in Duraes, MC Costa, CN Silva, EMBRAPA Holstein cattle HM Genotyping BoLA-DRB3 alleles in Brazilian Dairy Gir cattle (Bos indicus) by da Mota, AF Martinez, ML Univ Sao Paulo; temperature-gradient gel Coutinho, LL Natl Dairy Cattle Res Ctr electrophoresis (TGGE) and direct sequencing Herbaceous cotton yield in no-till system in rainfed Savannah conditions Correa, JC Sharma, RD with crop rotation Increasing the profitability of traditional, EMBRAPA; Schroth, G Moraes, V da Mota, planted rubber agroforests at the Tapajos Univ Bayreuth; MSS river, Brazilian Amazon INPA Infection by Neospora caninum associated with bovine herpesvirus 1 and de Melo, CB Leite, RC Lobato, Univ Fed Minas Gerais; bovine viral diarrhea virus in ZIP Leite, RC Univ Fed Sergipe cattle from Minas Gerais State, Brazil Influence of agronomic variables on the composition of mate tea leaves Esmelindro, AA Girardi, JD (Ilex paraguariensis) extracts Mossi, A Jacques, RA Dariva, URI obtained from CO2 extraction C at 30 degrees C and 175 bar Influence of dry matter and length of roots on growth of five field crops at varying soil Fageria, NK EMBRAPA zinc and copper levels Land-use change effects on local energy, Sakai, RK Fitzjarrald, DR SUNY Albany; water, and carbon balances in an Moraes, OLL Staebler, RM LBA ECO Logist Support

Título Autores Instituição Amazonian agricultural field Acevedo, OC Czikowsky, MJ Off Santarem; Da Silva, R Brait, E Miranda, V Univ Fed Santa Maria Traverso, SD Loretti, AP Lead poisoning in cattle in southern Brazil UFRGS Donini, MA Driemeier, D Mendham, DS Kumaraswamy, CSIRO Forestry & Legume cover cropping effects on early S Balasundaran, M Sankaran, Forest Prod; growth and soil nitrogen supply in eucalypt KV Corbeels, M Grove, TS Kerala Forest Res Inst; plantations in south-western India O'Connell, AM Rance, SJ CIRAD Univ Gottingen; Zentrum Entwicklungsforsch; Litter decomposition, microbial biomass Kurzatkowski, D Martius, C Staatl Museum and activity of soil organisms in three Hofer, H Garcia, M Forster, B Naturkunde; agroforestry sites in central Amazonia Beck, L Vlek, P Embrapa Amazonia Ocidental; ECT Okotoxikol GmbH Embrapa Amazonia Litter fall, litter stocks and decomposition Ocidental; Martius, C Hofer, H Garcia, rates in rainforest and agroforestry sites in ECT Oekotoxikol GmbH; MVB Rombke, J Hanagarth, W central Amazonia Ctr Dev Res ZEF Bonn; SMNK Long-term tillage and crop rotation effects Balota, EL Colozzi, A Andrade, Oregon State Univ; on microbial biomass and C and N DS Dick, RP IAPAR mineralization in a Brazilian Oxisol Microanalytical study of a ferrous agricultural tool recovered from a historical Campos, GN Solorzano, IG PUC Rio site in Rio de Janeiro Embrapa Amazonia Ocidental; Microclimate in agroforestry systems in Martius, C Hofer, H Garcia, Ctr Dev Res; central Amazonia: does canopy closure MVB Rombke, J Forster, B Staatliches Museum Nat matter to soil organisms? Hanagarth, W Kunde Karlsruhe; ECT Oekotoxikol GmbH Modeling the stability of wheeled Junior, JKK Dias, GP Cordeiro, Univ Fed Vicosa agricultural tractors RR de Souza, CWA Univ Bayreuth; Modelling species and spacing effects on Schlegel, P Huwe, B Teixeira, Empresa Brasileira root zone water dynamics using Hydrus- WG Pesquisa Agropecuaria 2D in an Amazonian agroforestry system Amazonia Oppenheimer, C Tsanev, VI Univ Cambridge; NO2 emissions from agricultural burning in Allen, AG McGonigle, AJS Univ Birmingham; Sao Paulo, Brazil Cardoso, AA Wiatr, A Paterlini, Univ Estadual Paulista W De Mello, C Nutrient digestibility in cattle diet with urea Junior, RCD Pires, AV Susin, I Univ Sao Paulo or starea replacing soybean meal Fernandes, JJD Santos, FAP Paulino, PVR Costa, MAL Valadares, SD Paulino, MF Nutritional requirements of zebu cattle. Valadares, RFD Magalhaes, UFV Energy KA de Moraes, EHBK Porto, MO Andreatta, K Paulino, PVR Costa, MAL Nutritional requirements of zebu cattle: Valadares, SD Paulino, MF UFV Minerals Valadares, RFD Magalhaes, KA Porto, MO Baroni, CES Paulino, PVR Costa, MAL Nutritional requirements of zebu cattle: Valadares, SD Paulino, MF UFV Protein Valadares, RFD Magalhaes, KA Porto, MO Andreatta, K Otitis in cattle, an aetiological review Duarte, ER Hamdan, JS Univ Fed Minas Gerais

Título Autores Instituição Passive immunity in cattle against enterotoxigenic Escherichia coli: serologic Figueiredo, HCP Lage, AP Univ Fed Lavras; evaluation of a bacterin containing K99 Pereira, FN Leite, RC EV UFMG and F41 fimbriae in colostrum of vaccinated females and calf serum Phosphatase activity in soil under Univ Fed Santa mycorrhizal and non-mycorrhizal cover Dalla Costa, M Lovato, PE Catarina crops Physical properties of a dystrophic Red Araujo, MA Tormena, CA USP; Latosol (oxisol) under crop cultivation and Silva, AP UEM native forest Physical soil properties of conventional Bertol, I Albuquerque, JA tillage and no-tillage, in crop rotation and Leite, D Amaral, AJ Zoldan, UDESC succession, compared with natural pasture WA Physiological and biochemical effects of Univ Sao Paulo; Hu, ZY Richter, H Sparovek, G rare earth elements on plants and their Chinese Acad Sci; Schnug, E agricultural significance: A review FAL Univ Sao Paulo; Predominant African-derived mtDNA in Univ Complutense Miretti, MM Dunner, S Naves, Caribbean and Brazilian Creole cattle is Madrid; M Contel, EP Ferro, JA also found in Spanish cattle (Bos taurus) INRA; Univ Estadual Paulista de Azevedo, JR Mannigel, RC Prevalence and geographical distribution Univ Estadual Maringa; Agulhon, AZ Borba, TR of bovine eurytrematosis in cattle CESUMAR; Barbieri, AW de Oliveira, DCL slaughtered in northern Parana, Brazil Ctr Univ Maringa Headley, SA Janeiro, V Prevalence of Neospora caninum USP; antibodies and factors associated with Guimaraes, JS Souza, SLP Univ Estadual their presence in dairy cattle of the north of Bergamaschi, DP Gennari, SM Londrina; Parana' state, Brazil Univ Sao Paulo Campos, D Artoni, L Teixeira, Progesterone production in cattle placenta A Kfoury, JR Miglino, MA Univ Sao Paulo; under the influence of VEGF and bFGF in Birgel, E Buratini, J Machado, IB UNESP vitro U Papa, P Puberty in South American Bos indicus Nogueira, GP UNESP (Zebu) cattle Redistribution of phosphorus roots in soil Franchini, JC Pavan, MA IAPAR through cover crop roots Miyazawa, M Univ Nebraska; Ohio State Univ; Univ Missouri; Regulation of frequency of luteinizing Fike, KE Kojima, FN Lindsey, Minitube Amer; hormone pulses by magnitude of acute BR Bergfeld, EGM Quintal- Amer Soc Agron; change in circulating concentration of Franco, JA Melvin, EJ Zanella, INIFAP SAGAR; progesterone of female cattle EL Wehrman, ME Kinder, JE Wake Forest Univ; EMBRAPA Suinos & Aves; Rocky Mt Reprod Serv Inc dos Santos, MSM Madalena, Repeatability of agro-industrial JA Soares, L Ferreira, PV Univ Fed Alagoas characteristics in sugar cane Barbosa, GVS Residual N and P fertilizer effect and fertilizer Sampaio, ESB Tiessen, H Univ Fed Pernambuco; recovery on intercropped and sole-cropped Antonino, ACD Salcedo, IH Univ Gottingen corn and bean in semiarid northeast Brazil Residues of acephate and its methamidophos metabolite in fruits from greenhouse and field Trevizan, LRP de Baptista, GC Univ Sao Paulo tomato crops Risk ratio as indicator of the number of animals Univ Estado Santa necessary for genetic mapping of complex Neto, AT Fries, R Thaller, G Catarina; binary traits in cattle Tech Univ Munich

Título Autores Instituição Risk Ratio as parameter for the genetic Univ Estado Santa Thaler-Neto, A Fries, R characterization of new defined traits for Catarina; Thaller, G mastitis of cattle Tech Univ Munich Simonelli, SM Silva, MA Silva, EMBRAPA Gado Corte; Selection criteria for growth traits in LOC Pereira, JCC Souza, JER UENF; Nellore cattle Ventura, RV Valente, BD UFMG Selectivity of six insecticides used in citrus Godoy, MS Carvalho, GA crops on pupae and adults of Chrysoperla Moraes, JC Cosme, LV UFLA; externa (Hagen) (Neuroptera : Goussain, MM Carvalho, CF Escola Super Agr Chrysopidae) Morais, AA Services performed by the ecosystem: forest remnants influence agricultural De Marco, P Coelho, FM Univ Fed Vicosa cultures' pollination and production Short intervals between ultrasonographically guided follicle Viana, JHM Camargo, LSD Eugenio Nascimento; aspiration improve oocyte quality but do Ferreira, AD de Sa, WF Univ Alfenas; not prevent establishment of dominant Fernandes, CAD Marques, AD Univ Fed Minas Gerais follicles in the Gir breed (Bos indicus) of cattle Slaughter weights for the production of da Cruz, GM Esteves, SN Embrapa Pecuaria young bull cattle. 1. Performance on Tullio, RR Alencar, MMD Sudeste; feedlot and cost of production Oliveira, MCD UNESP Slaughter weights for the production of da Cruz, GM Tullio, RR Embrapa Pecuaria young bull cattle. 2. Weight, age and Esteves, SN de Alencar, MM Sudeste carcass characteristics Cordeiro, CA Spatial distribution of Bemisia tabaci (Genn.) biotype B (Hemiptera : Pereira, MFA Boica, AL ESAPP; Aleyrodidae) on bean crop (Phaseolus Barbosa, JC UNESP vulgaris L.) Inst Nacl Pesquisas Espaciais; Spectral and temporal behavior analysis of Moreira, MA Adam, M Rudorff, Secretaria Estado Agr coffee crop in Landsat images BFT & Abastecimento Parana Systemic granulomatous disease in Brazilian cattle grazing pasture containing Fighera, RA Barros, CS Univ Fed Santa Maria vetch (Vicia spp) Temporal variation of soil penetration Junior, SAG Reinert, DJ CAAL; resistance in a Clayey oxisol under no- Reichert, JM Univ Fed Santa Maria tillage and crop rotation The impact of sector-specific and economy-wide policy reforms Univ Calif Riverside; Helfand, SM de Rezende, GC on the agricultural sector in Brazil: 1980- Univ Fed Fluminense 98 The incidence of Shiga toxin-producing Univ Sao Paulo; Escherichia coli in cattle with Lira, WM Macedo, C Marin, JM Univ Estadual Paulista mastitis in Brazil The use of hormonal treatments to Baruselli, PS Reis, EL FMVZ USP; improve reproductive performance of Marques, MO Nasser, LF Bo, Univ Catolica Cordoba anestrous beef cattle in tropical climates GA Total replacement of soybean meal by urea or starea in high grain diets on de Oliveira, RC Pires, AV nitrogen metabolism, ruminal ammonia-N Fernandes, JJD Susin, I USP concentration and blood parameters in Santos, FAP de Araujo, RC beef cattle Toxicity of leaf extracts of Ageratum Moreira, MD Picanco, MC conyzoides to lepidoptera pests of Barbosa, LCD Guedes, RNC Univ Fed Vicosa horticultural crops da Silva, LM

Em relação ao tema defesa agropecuária, apenas no termo Sistemas Efetivos de Monitoramento foram localizados dois artigos que que têm pelo menos um autor vinculado a uma instituição brasileira no título, cujos autores e Instituição de correspondência são apresentados a seguir. a. Sistemas Efetivos de Monitoramento

Título Autores Instituição Embrapa Instrumentacao Effect of no-till cropping systems on soil organic Agropecuaria; Bayer, C Martin- matter in a sandy clay loam Acrisol from Southern Univ Fed Santa Maria; Neto, L Mielniczuk, J Brazil monitored by electron spin resonance and Univ Fed Rio Grande Ceretta, CA nuclear magnetic resonance Sul; Univ Estado Santa Catarina Luchini, LC Peres, Ctr Protecao Monitoring of pesticide residues in a cotton crop soil TB de Andrea, MM Ambiental

8. TEMA: FARMACOGENÉTICA

Apresentam-se a seguir os títulos dos 2 artigos que tem pelo menos um autor vinculado a uma instituição brasileira, sobre o tema Farmacogenética, com seus respectivos autores e instituições.

Título Autores Instituição Attention-deficit/hyperactivity disorder: current Univ Fed Rio Rohde, LA Roman, T Hutz, MH aspects on pharmacogenetics Grande Sul

Novel CYP3A4 gene mutations: Contribution to Cavalli, S Moretti, I Matsumoto, L the pharmacogenetic profile of Salazar, L Hiroyuki, M Forti, N USP hypercholesterolemic individuals treated with Diament, J Chiara, M Faludi, A atorvastin Dominguez, R

Em relação aos termos referentes ao tema Farmacogenética, não foram localizados artigos que contenham pelo menos um autor vinculado a uma instituição brasileira.

9. TEMA: FERTILIDADE E REPRODUÇÃO ANIMAL

Apresenta-se a seguir o título, autor e instituição do artigo localizado de autor vinculado a uma instituição brasileira, sobre o tema Fertilidade e reprodução animal, com seus respectivos autores e instituições.

Título Autores Instituição Special issue: Research and practice III: 15th international congress on animal reproduction - Henry, M Univ Fed Minas Gerais Preface

Em relação aos termos referentes ao tema Fertilidade e reprodução animal, não foram localizados artigos que contenham pelo menos um autor vinculado a uma instituição brasileira.

10. TEMA: INTEGRAÇÃO: ALIMENTAÇÃO, NUTRIÇÃO E SAÚDE

Não foram localizados artigos que contenham especificamente o tema Integração: alimentação, nutrição e saúde. Em relação aos termos referentes ao tema Integração: alimentação, nutrição e saúde, em dois termos (Nutracêuticos (Alimentos Funcionais) e Produção de Vacinas em Plantas e Animais) foram localizados artigos publicados por pelo menos um autor vinculado a instituição brasileira. Os títulos dos artigos, seus autores e instituições, são apresentados a seguir.

a. Nutracêuticos (Alimentos Funcionais)

Título Autores Instituição Biochemical pharmacology of functional foods and prevention of Ferrari, CKB Univ Sao chronic diseases of aging Torres, EAFS Paulo Functional foods, herbs and nutraceuticals: towards biochemical Univ Sao Ferrari, CKB mechanisms of healthy aging Paulo Univ Sao Functional foods: Latin American perspectives Lajolo, FA Paulo Soccol, MCH Seafood as functional food USP Oetterer, M b. Produção de Vacinas em Plantas e Animais

Título Autores Instituição EVALUATION OF DIFFERENT MEAT PEPTONES AS CULTURE MEDIA FOR POESTER, FP RAMOS, ET

BRUCELLA-ABORTUS 19 VACCINE GIANNOULAKIS, MK PRODUCTION Polygenic control of antibody production and correlation with vaccine induced resistance to DeFranco, M Massa, S Vassao, INST rabies virus in high and low antibody responder RC Siqueira, M SantAnna, OA BUTANTAN mice

Título Autores Instituição

Production and targeting of the Brucella abortus Ribeiro, LA Azevedo, V Le Loir, Y INRA; antigen L7/L12 in Lactococcus lactis: a first step Oliveira, SC Dieye, Y Piard, JC Univ Fed towards food-grade live vaccines against Gruss, A Langella, P Minas Gerais brucellosis

Stepwise iodination. A general procedure for Univ Fed detoxification of proteins suitable for vaccine Heneine, IF Heneine, LGD Minas Gerais; development and antiserum production FUNED FIOCRUZ; The early use of yellow fever virus strain 17D for Post, PR de Carvalho, R Freire, Univ Fed vaccine production in Brazil - A review MD Galler, R Pelotas

11. TEMA: MUDANÇAS CLIMÁTICAS GLOBAIS

Apresenta-se a seguir os títulos dos 29 artigos que têm pelo menos um autor vinculado a uma instituição brasileira, sobre o tema Mudanças climáticas globais, com seus respectivos autores e instituições. Título Autores Instituição A crisis in the making: responses of Natl Inst Res Amazonian forests to land use and Laurance, WF Amazon INPA; climate change Smithsonian Inst A mathematical model for malaria Univ Estadual transmission relating global warming Yang, HM Campinas and local socioeconomic conditions Amazonian deforestation and global warming: Carbon stocks in Fearnside, PM vegetation replacing Brazil's Amazon forest Assessing the effects of global Univ Estadual warming and local social and economic Yang, HM Ferreira, MU Campinas; conditions on the malaria transmission Univ Sao Paulo Pontificia Univ Assessing the health benefits of urban Catolica Chile; air pollution reductions associated with Secretaria Salud; Cifuentes, L Borja-Aburto, VH Gouveia, climate change mitigation (2000-2020): USP; N Thurston, G Davis, DL Santiago, Sao Paulo, Mexico City, and Carnegie Mellon New York City Univ; NYU UNIV WATERLOO; Martinelli, LA Pessenda, LCR Carbon-13 variation with depth in soils UNIV Espinoza, E Camargo, PB Telles, EC of Brazil and climate change during the WASHINGTON; Cerri, CC Victoria, RL Aravena, R quaternary UNIV CALIF Richey, J Trumbore, S IRVINE Climate change after tropical deforestation: Seasonal variability of Berbert, MLC Costa, MH Univ Fed Vicosa surface albedo and its effects on precipitation change Kenya Med Res Inst; Climate change and vector-borne Githeko, AK Lindsay, SW Confalonieri, Univ Durham; diseases: a regional analysis UE Patz, JA Natl Sch Publ Hlth; Johns Hopkins Univ

Título Autores Instituição Direcc Gen Salud Ambiental; Pontificia Univ Climate change: Hidden health benefits Cifuentes, L Borja-Aburto, VH Gouveia, Catolica Chile; of greenhouse gas mitigation N Thurston, G Davis, DL Univ Sao Paulo; Carnegie Mellon Univ; NYU Developing countries are combating World Resources climate change - Actions in developing Reid, WV Goldemberg, J Inst; countries that slow growth in carbon Univ Sao Paulo emissions Expected climate change impacts on Nearing, MA Pruski, FF O'Neal, MR soil erosion rates: A review Forests and global warming mitigation in Brazil: opportunities in the Brazilian Inst Nacl forest sector for responses to global Fearnside, PM Pesquisas warming under the "clean development Amazonia mechanism" Further evidence of changes in the hydrological regime of the River Inst Pesquisas Collischonn, W Tucci, CEM Clarke, RT Paraguay: part of a wider phenomenon Hidraul of climate change? Future electric power technology choices of Brazil: a possible conflict Schaeffer, R Szklo, AS UFRJ between local pollution and global climate change Global warming and transport in Brazil Ribeiro, SK Younes-Ibrahim, PS UFRJ - ethanol alternative Global warming and tropical land-use change: Greenhouse gas emissions from biomass burning, Natl Inst Res Fearnside, PM decomposition and soils in forest Amazon conversion, shifting cultivation and secondary vegetation GLOBAL WARMING POTENTIALS - THE CASE OF EMISSIONS FROM ROSA, LP SCHAEFFER, R DAMS Global warming response options in Brazil's forest sector: Fearnside, PM Comparison of project-level costs and benefits UFRJ; Indira Gandhi Inst Beg, N Morlot, JC Davidson, O Afrane- Dev Res; Linkages between climate change and Okesse, Y Tyani, L Denton, F Sokona, OECD; sustainable development Y Thomas, JP La Rovere, EL Parikh, BCAS; JK Parikh, K Rahman, AA EDRC; ENDA TM Lutzomyia vectors for cutaneous leishmaniasis in Southern Brazil: Univ Kansas; ecological niche models, predicted Peterson, AT Shaw, J Univ Sao Paulo geographic distributions, and climate change effects Smithsonian Trop Positive feedbacks among forest Res Inst; fragmentation, drought, and climate Laurance, WF Williamson, GB Natl Inst change in the Amazon Amazonian Res; Louisiana State

Título Autores Instituição Univ Saving tropical forests as a global Natl Isnt Res warming countermeasure: an issue that Fearnside, PM Amazon divides the environmental movement Natl Marine Fisheries Serv; Marine & Coastal Management; Plymouth Marine Lab; Ctr Reg Invest Pesqueras; Inst Politecn Nacl; Natl Fisheries Res & Dev Inst; Jacobson, LD De Oliveira, JAA Inst Mar Peru; Barange, M Cisneros-Mata, MA Felix- Surplus production, variability, and Univ Sao Paulo; Uraga, R Hunter, JR Kim, JY Matsuura, climate change in the great sardine and Ctr Oceanog Vigo; Y Niquen, M Porteiro, C Rothschild, B anchovy fisheries Univ Sanchez, RP Serra, R Uriarte, A Wada, Massachusetts; T Inst Nacl Invest & Desarrollo Pesquero; Inst Fomento Pesquero; Inst Tecnol Pesquero & Alimentario; Japan Minist Agr Forestry & Fisheries Sustainable forest management and global climate change: Selected case Da Motta, RS IPEA studies from the Americas Sustainable forest management and global climate change: Selected case Da Motta, RS IPEA studies from the Americas. Univ Fed Rio de The present, past, and future Janeiro; contributions to global warming of CO2 Rosa, LP Ribeiro, SK Int Virtual Inst emissions from fuels Global Change Time preference in global warming calculations: a proposal for a unified Fearnside, PM INPA index Uncertainty in land-use change and forestry sector mitigation options for Natl Inst Res Fearnside, PM global warming: Plantation silviculture Amazon INPA versus avoided deforestation

Em relação aos termos referentes ao tema Mudanças climáticas globais, não foram localizados artigos que contenham pelo menos um autor vinculado a uma instituição brasileira.

12. TEMA: PROGRAMAS DE DESCOBERTA

Sobre este tema em quatro termos – clonagem, células tronco, genômica funcional, proteômica - foram localizados artigos que referem-se em seu título ao Brasil. Os títulos dos artigos, seus autores e instituições são apresentados a seguir. a. Clonagem

Título Autores Instituição Silva, MB Schattner, M Ramos, CRR Inst Butantan; Junqueira-de-Azevedo, ILM Univ Fed A prothrombin activator from Bothrops Guarnieri, MC Pernambuco; erythromelas (jararaca-da-seca) snake Lazzari, MA Univ Fed Sao venom: characterization and molecular Sampaio, CAM Paulo; cloning Pozner, RG Consejo Nacl Invest Ventura, JS Cient & Tecn Ho, PL Chudzinski-Tavassi, AM A rolling-circle miniplasmid of Xanthomonas Baldini, RL campestris pv. glycines: The nucleotide UNICAMP Tahara, ST Rosato, YB sequence and its use as a cloning vector Inoue-Nagata, AK Embrapa A simple method for cloning the complete Albuquerque, LC Hortalicas; begomovirus genome using the Rocha, WB Univ Catolica bacteriophage phi 29 DNA polymerase Nagata, T Brasilia Surpili, MJ Inst Genbiol Forsch A yeast-based model system for cloning Muller-Rober, B Berlin GmbH; secreted and membrane proteins Willmitzer, L MPI MOPP Cent Univ An improved general approach for cloning Chiurillo, MA Venezuela; and characterizing telomeres: the protozoan Santos, MRM Inst Estudios parasite Trypanosoma cruzi as model Da Silveira, JF Avanzados IDEA; organism Ramirez, JL Escola Paulista Med Unifesp Valente, RH Univ Fed Rio de BJ46a, a snake venom metalloproteinase Dragulev, B Janeiro; inhibitor - Isolation, characterization, cloning Perales, J Univ Virginia; and insights into its mechanism of action Fox, JW FIOCRUZ Domont, GB Facincani, AP Ferro, JA Carbohydrate metabolism of Xylella Pizauro, JM fastidiosa: Detection of glycolytic and Univ Estadual Pereira, HA pentose phosphate pathway enzymes and Paulista Lemos, EGD cloning and expression of the enolase gene do Prado, AL Ferro, MIT Almeida, MS Cabral, KS cDNA cloning and heterologous expression de Medeiros, LN Univ Fed Rio de of functional cysteine-rich antifungal protein Valente, AP Janeiro Psd1 in the yeast Pichia pastoris Almeida, FCL Kurtenbach, E

Título Autores Instituição CDNA cloning and sequence analysis of a OKLAHOMA deAraujo, HSS lysine-49 phospholipase A(2) myotoxin from STATE UNIV; White, SP Agkistrodon contortrix laticinctus snake UNIV FED SAO Ownby, CL venom CARLOS Ferreira, CAS Barbosa, MC UFRGS; cDNA cloning, expression and Silveira, TCL NIAID; characterization of a Boophilus microplus Valenzuela, JG PUC RS; paramyosin Vaz, ID UNISINOS Masuda, A Lasakosvitsch, F Cloning and characterisation of a cysteine Gentil, LG proteinase gene expressed in amastigotes of dos Santos, MRM Univ Fed Sao Paulo Leishmania (L.) amazonensis da Silveira, JF Barbieri, CL de Oliveira, UC Cloning and characterization of a basic Assui, A phospholipase A(2) homologue from Univ Sao Paulo; de Brandao Prieto da Silva, AR Micrurus corallinus (coral snake) venom Ctr Biotecnol de Oliveira, JS gland Ho, PL Araujo, CA Waniek, PJ Cloning and characterization of a defensin- Ruhr Univ Bochum; Jansen, AM encoding cDNA of Triatoma brasiliensis Inst Oswaldo Cruz Kollien, AK Schaub, GA Lesenechal, M Duret, L ECOLE NORMALE Cano, MI SUPER LYON; Cloning and characterization of a gene Mortara, RA LAB BIOMETRIE; encoding a novel immunodominant antigen Jolivet, M ESCOLA of Trypanosoma cruzi Camargo, ME PAULISTA MED; daSilveira, JF BIOLAB MERIEUX ParanhosBaccala, G Fragoso, SP Plazanet-Menut, C Univ Fed Rio de Cloning and characterization of a gene Carreira, MAC Janeiro; encoding a putative protein associated with Motta, MC Inst Biol Mol U3 small nucleolar ribonucleoprotein in Dallagiovana, B Parana; Trypanosoma cruzi Krieger, MA Fiocruz MS Goldenberg, S Campos-Neto, A Suffia, I Cavassani, KA Cloning and characterization of a gene encoding Jen, S Univ Sao Paulo; an immunoglobulin-binding receptor on the cell Greeson, K Infect Dis Res Inst; surface of some members of the family Ovendale, P Corixa Corp Trypanosomatidae Silva, JS Reed, SG Skeiky, YAW Cloning and characterization of a gene Ribon, AOB Coelho, JLC de encoding the endopolygalacturonase of Univ Fed Vicosa Barros, EG Araujo, EF Penicillium griseoroseum CLONING AND CHARACTERIZATION OF A ARAYA, JE GENE FOR THE STAGE-SPECIFIC 82-KDA CANO, MI ESCOLA SURFACE-ANTIGEN OF METACYCLIC YOSHIDA, N PAULISTA MED TRYPOMASTIGOTES OF TRYPANOSOMA- DA SILVEIRA, JF CRUZI Cloning and characterization of a LON gene Barros, TF homologue from the human pathogen UNIFESP Puccia, R Paracoccidioides brasiliensis

Título Autores Instituição Vianna, CR Cloning and characterization of a novel Bicudo, JEPW Univ Sao Paulo; uncoupling protein homologue in Moriscot, AS Harvard Univ hummingbirds Bradford, LB Bianco, AC Univ Fed Rio de CLONING AND CHARACTERIZATION OF A DEMENDONCA, RL Janeiro; PUTATIVE CALCIUM-TRANSPORTING BECK, E UNIV ATPASE GENE FROM SCHISTOSOMA- RUMJANEK, FD CATHOLIQUE MANSONI GOFFEAU, A LOUVAIN; UNIV GIESSEN Cloning and characterization of a putative Harvard Univ; Huang, TS Yang, WX Pereira, human D-2-hydroxyacid dehydrogenase in FMUSP; AC Craigen, WJ Shih, VE chromosome 9q Baylor Coll Med Magdesian, MH Cloning and characterization of a repetitive daSilva, ARBP 1.9 kb HindIII DNA fragment from Crotalus Ho, PL Inst Butantan durissus terrificus genome Furtado, MFD Yamane, T Cloning and characterization of a Schistosoma mansoni cDNA clone with a Coelho Castelo, AM Univ Sao Paulo specific antigenic expression during Rodrigues, V development in a vertebrate host CHEN, I CLONING AND CHARACTERIZATION OF MARCOS, AT Univ Sao Paulo; AN ALPHA-AMYLASE GENE FROM DACOSTA, SOP UNIV LEON STREPTOMYCES SP WL6 MARTIN, JF PADILLA, G de Oliveira, JS da Silva, ARDP Cloning and characterization of an alpha- Soares, MB Inst Butantan; neurotoxin-type protein specific for the coral Stephano, MA Univ Iowa snake Micrurus corallinus Dias, WD Raw, I Ho, PL Souza, RL Cloning and characterization of COX18, a Univ Sao Paulo; Green-Willms, NS Saccharomyces cerevisiae PET gene Univ Vale Paraiba; Fox, TD required for the assembly of cytochrome Cornell Univ; Tzagoloff, A oxidase Columbia Univ Nobrega, FG Cloning and characterization of Echinococcus Gimba, ERP granulosus (Cestode) EgactI and EgactII actin Chemale, G Univ Fed Rio Grande gene promoters and their functional analysis in Farias, SS Sul the NIH3T3 mouse cell line Zaha, A de Souza, PRE Ctr Pesquisas Aggeu Valadao, AF Magalhaes Fiocruz; Cloning and characterization of SmZF1, a gene Calzavara-Silva, CE Univ Fed encoding a Schistosoma mansoni zinc finger Franco, GR Pernambuco; protein de Morais, MA Univ Fed Minas Abath, FGC Gerais Cloning and characterization of the cDNA for the Viviani, VR Univ Estadual Sao Brazilian Cratomorphus distinctus larval firefly Arnoldi, FGC Paulo; luciferase: similarities with European Lampyris Brochetto-Braga, M Osaka Natl Res Inst noctiluca and Asiatic Pyrocoelia luciferases Ohmiya, Y CLONING AND CHARACTERIZATION OF THE GENE ENCODING ATP-DEPENDENT Fdn Oswaldo Cruz; LINSS, J PHOSPHO-ENOL-PYRUVATE JOHNS HOPKINS GOLDENBERG, S CARBOXYKINASE IN TRYPANOSOMA-CRUZI - UNIV; URBINA, JA COMPARISON OF PRIMARY AND PREDICTED INST VENEZOLANO AMZEL, LM SECONDARY STRUCTURE WITH HOST CTP- INVEST CIENT DEPENDENT ENZYME

Título Autores Instituição CLONING AND CHARACTERIZATION OF THE GENE ENCODING ATP-DEPENDENT Fdn Oswaldo Cruz; PHOSPHO-ENOL-PYRUVATE LINSS, J JOHNS HOPKINS CARBOXYKINASE IN TRYPANOSOMA- GOLDENBERG, S UNIV; CRUZI - COMPARISON OF PRIMARY AND URBINA, JA INST PREDICTED SECONDARY AMZEL, LM VENEZOLANO STRUCTURE WITH HOST GTP- INVEST CIENT DEPENDENT ENZYME (VOL 136, PG 69, 1993) Sperandio, V Bailey, C UNIV MARYLAND; Cloning and characterization of the gene Giron, JA UNIV MICHIGAN; encoding the OmpU outer membrane protein DiRita, VJ Univ Estadual of Vibrio cholerae Silveira, WD Campinas Vettore, AL Kaper, JB Cloning and characterization of the gene Braz, VS encoding the PepF endopeptidase from the Lang, EAS Univ Sao Paulo aquatic bacterium Caulobacter crescentus Marques, MV CLONING AND CHARACTERIZATION OF DE OLIVEIRA, JCF THE GENE FOR THE CATALYTIC BORGES, ACC SUBUNIT OF CAMP-DEPENDENT Univ Sao Paulo MARQUES, MD PROTEIN-KINASE IN THE AQUATIC GOMES, SL FUNGUS BLASTOCLADIELLA-EMERSONII Inst Biol Mol Avila, AR Parana; Yamada-Ogatta, SF Cloning and characterization of the Univ Estadual Monteiro, VDS metacyclogenin gene, which is specifically Londrina; Krieger, MA expressed during Trypanosoma cruzi Fiocruz MS; Nakamura, CV metacyclogenesis Univ Estadual de Souza, W Maringa; Goldenberg, S UFRJ Rebelo, MF Cloning and detection of metallothionein Univ Fed Rio de Pfeiffer, WC mRNA by RT-PCR in mangrove oysters Janeiro; da Silva, H (Crassostrea rhizophorae) Fiocruz MS Moraes, MO CAMPOSNETO, A SOONG, L CLONING AND EXPRESSION OF A CORDOVA, JL LEISHMANIA-DONOVANI GENE SANTANGELO, D INSTRUCTED BY A PEPTIDE ISOLATED Univ Sao Paulo; SKEIKY, YAW FROM MAJOR HISTOCOMPATIBILITY YALE UNIV RUDDLE, NH COMPLEX CLASS-II MOLECULES OF REED, SG INFECTED MACROPHAGES JANEWAY, C MCMAHONPRATT, D Roberto, PG Kashima, S Soares, AM Univ Fed Rio de Cloning and expression of an acidic platelet Chioato, L Janeiro; aggregation inhibitor phospholipase A(2) Faca, VM Univ Sao Paulo; cDNA from Bothrops jararacussu venom Fuly, AL Univ Ribeirao Preto; gland Astolfi, S Univ Fed Amazonas Pereira, JO Franca, SC Univ Sao Paulo; Cloning and expression of calglandulin, a Junqueira-de-Azevedo, ID Inst Butantan; new EF-hand protein from the venom glands Pertinhez, T Spisni, A Carreno, Ctr Biol Mol of Bothrops insularis snake in E-coli FR Farah, CS Ho, PL Estrutural; Univ Parma

Título Autores Instituição Cloning and expression of colonization factor Univ Sao Paulo; Luna, MG Martins, MM Newton, antigen I (CFA/I) epitopes of enterotoxigenic INST BIOFIS SMC Costa, SOP Almeida, DF Escherichia coli (ETEC) in Salmonella CARLOS CHAGAS Ferreira, LCS flagellin FILHO Cloning and expression of functional Magalhaes, MLB Pereira, CP Univ Fed Rio shikimate dehydrogenase (EC 1.1.1.25) from Basso, LA Santos, DS Grande Sul Mycobacterium tuberculosis H37Rv Cloning and expression of soluble recombinant protein comprising the Yoon, SO Hirata, RDC da Silva, Univ Sao Paulo; extracellular domain of the human type I ACR Nguyen, NY Hirata, MH US FDA interferon receptor 2c subunit (IFNAR-2c) in E-coli Univ Sao Paulo; Vianna, CR Hagen, T Zhang, CY Brigham & Womens Cloning and functional characterization of an Bachman, E Boss, O Gereben, B Hosp; uncoupling protein homolog in hummingbirds Moriscot, AS Lowell, BB Bicudo, Harvard Univ; JEPW Bianco, AC Beth Israel Deaconess Med Ctr Renard, G Garcia, JF Cardoso, UFRGS; Cloning and functional expression of a FC Richter, MF Sakanari, JA Univ Fed Rio Boophilus microplus cathepsin L-like enzyme Ozaki, LS Termignoni, C Grande Sul; Masuda, A Sonoma State Univ Cloning and molecular characterization of the Viviani, VR Silva, ACR Perez, cDNA for the Brazilian larval click-beetle GLO Santelli, RV Bechara, EJH Univ Sao Paulo Pyrearinus termitilluminans luciferase Reinach, FC Cloning and molecular characterization of the Souza, PP Santos, DN Pena, Univ Fed Minas Schistosoma mansoni genes RbAp48 and SDJ Franco, GR Gerais histone H4 Cloning and overexpression in soluble form of functional shikimate kinase and 5- Oliveira, JS Pinto, CA Basso, LA Univ Fed Rio enolpyruvylshikimate 3-phosphate synthase Santos, DS Grande Sul enzymes from Mycobacterium tuberculosis NIAID; Cloning and partial characterization of a Ferreira, CAS Vaz, ID da Silva, Univ Fed Pelotas; Boophilus microplus (Acari : Ixodidae) SS Haag, KL Valenzuela, JG Univ Fed Rio calreticulin Masuda, A Grande Sul Cloning and partial characterization of a de Lima, MFR Ferreira, CAS de NIAID; Boophilus microplus (Acari : Ixodidae) Freitas, DRJ Valenzuela, JG Univ Fed Rio glutathione S-transferase Masuda, A Grande Sul Murayama, N Hayashi, MAF Ohi, Cloning and sequence analysis of a Bothrops H Ferreira, LAF Hermann, VV Univ Sao Paulo; jararaca cDNA encoding a precursor of Saito, H Fujita, Y Higuchi, S SHOWA UNIV; seven bradykinin-potentiating peptides and a Fernandes, BL Yamane, T Inst Butantan C-type natriuretic peptide DeCamargo, ACM Cloning and sequencing of tccb, a gene Nobrega, OT Silva, MAS encoding a Trypanosoma cruzi cathepsin B- Univ Brasilia Teixeira, ARL Santana, JM like protease Cloning and sequencing of the nitrogenase Machado, IMP Yates, MG Univ Fed Parana; structural genes nifHDK of Herbaspirillum Machado, HB Souza, EM UNIV SUSSEX seropedicae Pedrosa, FO Ribeiro, DT Machado, CR Costa, Cloning of a cDNA from Arabidopsis thaliana Univ Sao Paulo; RMA Praekelt, UM Van Sluys, homologous to the human XPB gene USP MA Menck, CFM CLONING OF A CDNA-ENCODING A DEMARIA, AC GOMES, SL Univ Sao Paulo; NOVEL HEAT-SHOCK PROTEIN FROM JULIANIA, MH MAZZARELLA, R ST LOUIS UNIV DICTYOSTELIUM-DISCOIDEUM KLEIN, C CLONING OF A CDNA-ENCODING A PUTATIVE CYSTEINE PROTEASE FROM DEBARROS, EG LARKINS, BA UNIV ARIZONA GERMINATING MAIZE SEEDS

Título Autores Instituição Cloning of a chitinase gene from Ewingella Inglis, PW Peberdy, JF Sockett, americana, a pathogen of the cultivated Univ Nottingham RE mushroom, Agaricus bisporus CLONING OF A FRAGMENT OF THE GENE CRYIVB FROM BACILLUS- THURINGIENSIS VAR ISRAELENSIS SAAR, JH DEGRAVE, WM Inst Oswaldo Cruz CODING FOR THE AMINOTERMINAL SEGMENT OF A 130-KDA LARVICIDAL ENDOTOXIN CLONING OF A LOCUS INVOLVED IN PATHOGENICITY AND PRODUCTION OF ROSATO, YB DESTEFANO, EXTRACELLULAR POLYSACCHARIDE UNIV CAMPINAS SAL DANIELS, MJ AND PROTEASE IN XANTHOMONAS- CAMPESTRIS PV CAMPESTRIS CLONING OF A RECA-LIKE GENE FROM STEFFENS, MBR RIGO, LU THE DIAZOTROPH HERBASPIRILLUM- FUNAYAMA, S SOUZA, EM Univ Fed Parana SEROPEDICAE STRAIN Z78 MACHADO, HB PEDROSA, FO Cloning of a surface membrane glycoprotein specific for the infective form of Giordano, R Fouts, DL Tewari, D Univ Sao Paulo; Trypanosoma cruzi having adhesive Colli, W Manning, JE Alves, MJM Univ Calif Irvine properties to laminin AMARANTEMENDES, JGP CLONING OF A THYMIC STROMAL CELL Univ Sao Paulo; CHAMMAS, R ABRAHAMSOHN, CAPABLE OF PROTECTING LUDWIG INST P PATEL, PC POTWOROWSKI, THYMOCYTES FROM APOPTOSIS CANC RES EF MACEDO, MS Cloning of an unusual natriuretic peptide Ho, PL Soares, MB Maack, T Inst Butantan; from the South American coral snake Gimenez, I Puorto, G Furtado, Cornell Univ; Micrurus corallinus MDD Raw, I Columbia Univ Kalapothakis, E Penaforte, CL Cloning of cDNAs encoding neurotoxic Beirao, PSL Romano-Silva, MA Univ Fed Minas peptides from the spider Phoneutria Cruz, JS Prado, MAM Gerais nigriventer Guimaraes, PEM Gomez, MV Prado, VF Univ Sao Paulo; Cloning of glucocorticoid-regulated genes in Valentini, SR Armelin, MCS Univ Estadual C6/ST1 rat glioma phenotypic reversion Paulista CLONING OF METALLOPROTEASE GENES IN THE CARPET VIPER (ECHIS- PAINE, MJI MOURADASILVA, PYRAMIDUM-LEAKEYI) - FURTHER Inst Butantan; AM THEAKSTON, RDG MEMBERS OF THE UNIV LIVERPOOL CRAMPTON, JM METALLOPROTEASE/DISINTEGRIN GENE FAMILY Cloning of the chaperonin t-complex polypeptide 1 gene from Schistosoma Univ Brasilia; Campos, EG Hamdan, FF mansoni and studies of its expression levels McGill Univ under heat shock and oxidative stress Univ Sao Paulo; Brigham & Womens Cloning of the t(1;5)(q23;q33) in a Hosp; myeloproliferative disorder associated with Wilkinson, K Velloso, E Lopes, L Harvard Univ; eosinophilia: Involvement of PDGFRB and Lee, C Aster, J Shipp, M Aguiar, RC Hosp AC Camargo response to imatinib. Fund Antonio Prudente Univ Sao Paulo; Harvard Univ; Cloning of the t(l;5)(q23;q33) in a Wilkinson, K Velloso, ERP Lopes, LF Hosp AC Camargo myeloproliferative disorder associated with Lee, C Aster, JC Shipp, MA Aguiar, Fund Antonio eosinophilia: involvement of PDGFRB and RCT Prudente; response to imatinib Dana Farber Canc Inst

Título Autores Instituição CLONING SHRIMP BACULOVIRUS- PENAEI DNA AND HYBRIDIZATION COMPARISON WITH MACHADO, CR BUENO, SLD Univ Sao Paulo AUTOGRAPHA-CALIFORNICA MENCK, CFM NUCLEAR POLYHEDROSIS- VIRUS Kalapothakis, E Penaforte, CL Cloning, cDNA sequence analysis and patch Leao, RM Cruz, JS Prado, VF Fdn Ezequiel Dias; clamp studies of a toxin from the Cordeiro, MN Diniz, CR Romano- Univ Fed Minas venom of the armed spider (Phoneutria Silva, MA Prado, MAM Gomez, Gerais nigriventer) MV Beirao, PSL Cloning, characterization and preliminary Monzani, PS Alfonzo, JD Univ Sao Paulo; crystallographic analysis of Leishmania Simpson, L Oliva, G Thiemann, Univ Calif Los hypoxanthine-guanine OH Angeles phosphoribosyltransferase Univ Khartoum; Cloning, characterization and serological Bhatia, A Daifalla, NS Jen, SY Infect Dis Res Inst; evaluation of K9 and K26: two related Badaro, R Reed, SG Skeiky, Corixa Corp; hydrophilic antigens of Leishmania chagasi YAW Univ Fed Bahia; Univ Washington Cloning, characterization, and epitope Cisalpino, PS Puccia, R expression of the major diagnostic antigen of Yamauchi, LM Cano, MIN Univ Fed Sao Paulo Paracoccidioides brasiliensis daSilveira, JF Travassos, LR Univ Fed Rio de Guimaraes-Gomes, V Oliveira- Janeiro; Cloning, characterization, and structural Carvalho, AL Junqueira-De- IBU; analysis of a C-type lectin from Bothrops Azevedo, IDM Dutra, DLS Pujol- Univ Sao Paulo; insularis (BiL) venom Luz, M Castro, HC Ho, PL Univ Fed Zingali, RB Fluminense Cloning, expression and partial Hokkaido Univ; characterization of a Haemaphysalis Vaz, ID Imamura, S Ohashi, K Univ Fed Rio longicornis and a Rhipicephalus Onuma, M Grande Sul appendiculatus glutathione S-transferase Cloning, expression and preliminary Univ Sao Paulo; crystallographic studies of the potential drug Pereira, HM Cleasby, A Pena, Astex Technol; target purine nucleoside phosphorylase from SDJ Franco, GR Garratt, RC UFMG Schistosoma mansoni Cloning, expression and purification of the large and small hydrophilic loops of Hering, VR VerjovskiAlmeida, S Univ Sao Paulo sarcoplasmic reticulum Ca-ATPase. Univ Sao Paulo; Cloning, expression, and characterization of Butera, D Skielka, K McLane, MA Inst Butantan; a bi-functional disintegrin/alkaline Paquette-Straub, C Ducancel, F Univ Delaware; phosphatase hybrid protein da Silva, AMM CEA Saclay State Univ Cloning, expression, and purification of the Catani, CF Azzoni, AR Paula, DP Campinas; virulence-associated protein D from Xylella Tada, SFS Rosselli, LK de Univ Estadual fastidiosa Souza, AP Yano, T Campinas Cloning, expression, and structural analysis Kassab, BH de Carvalho, DD Univ Estadual of recombinant BJcuL, a c-type lectin from Oliveira, MA Baptista, GR Campinas; the Bothrops jararacussu snake venom Pereira, GAG Novello, JC Inst Butanta Cloning, Golgi localization, and enzyme activity of the full-length hepa Crawford, BE Olson, SK Esko, Univ Calif San rin/heparan sulfate-glucuronic acid C5- JD Pinhal, MAS Diego epimerase Silva, RG Carvalho, LPS Univ Fed Rio Cloning, overexpression, and purification of Oliveira, JS Pinto, CA Mendes, Grande Sul; functional human purine MA Palma, MS Basso, LA Univ Estado Sao nucleoside phosphorylase Santos, DS Paulo

Título Autores Instituição UNIFESP; Cloning, purification, crystallization and Inst Butantan; preliminary X-ray diffraction analysis of the Max Planck Inst Rester, U Bode, W Sampaio, antistasin-type inhibitor ghilanten (domain I) Biochem; CAM Auerswald, EA Lopes, APY from Haementeria ghilianii in complex with Univ Munich porcine beta-trypsin Klinikum; Univ Munich Cloning, sequence analysis, and expression of active Phrixothrix railroad-worms Viviani, VR Bechara, EJH Univ Sao Paulo; luciferases: Relationship between Ohmiya, Y Univ Shizuoka bioluminescence spectra and primary structures Cloning, structural analysis and expression DeMaria, AC Moerman, A Klein, ST LOUIS UNIV; of the gene encoding Hsp32 from C Gomes, SL Univ Fed Sao Paulo Dictyostelium discoideum Coherent soliton propagation through doped Cavalcanti, SB Fonseca, EJD optical fibers: cloning, breakup, and soliton Univ Fed Alagoas Caetano, DP Hickmann, JM interactions Medeiros, MA Dellagostin, OA Comparative evaluation of Mycobacterium Armoa, GRG Degrave, WM de Oswaldo Cruz Fdn; vaccae as a surrogate cloning host for use in Mendonca-Lima, L Lopes, MQ Fed Univ Pelotas; the study of mycobacterial genetics Costa, JF Mcfadden, J McIntosh, Univ Surrey D Construction of a cloning vector for Univ Fed Rio de Duarte, GF Seldin, L Paenibacillus polymyxa and P-azotofixans Janeiro Univ Florida; Detection and cloning of expressed Vallejos, CE Malandro, JJ Empresa Brasileira sequences linked to a target gene Sheehy, K Zimmermann, MJ Pesquisa Agropecuaria Echinococcus granulosus: Cloning and Cortez-Herrera, E Yamamoto, Univ Fed Rio functional in vitro characterization of an actin RR Rodrigues, JSS Farias, SE Grande Sul filament fragmenting protein Ferreira, HB Zaha, A Echinococcus granulosus: Fernandez, V Chalar, C Univ Fed Rio Molecular cloning and phylogenetic Martinez, C Musto, H Zaha, A Grande Sul; analysis of an inducible glutathione S- Fernandez, C Univ Republ transferase Establishment of an expression cloning Fujii, S Uemura, Y Iwai, LK Ando, Univ Sao Paulo; system for CD4(+) T cell epitopes M Senju, S Nishimura, Y Kumamoto Univ Genetic analysis of the bacteriocin-encoding plasmids pRJ6 and pRJ9 of de Oliveira, SS Nascimento, JDS Staphylococcus aureus by transposon Povoa, DC de Araujo, SA UFRJ mutagenesis and cloning of genes involved Gamon, MR Bastos, MCD in bacteriocin production Glycerol kinase of Trypanosoma brucei - Catholic Univ Kralova, I Rigden, DJ Cloning, molecular characterization and Louvain; Opperdoes, FR Michels, PAM mutagenesis EMBRAPA Univ Fed Rio de Human serine racemase: moleular cloning, De Miranda, J Santoro, A Janeiro; genomic organization and functional analysis Engelender, S Wolosker, H Inst Ciencias Biomed Infect Dis Res Inst; Identification and characterization of T cell- Probst, P Stromberg, E Ghalib, Corixa Corp; stimulating antigens from Leishmania by HW Mozel, M Badaro, R Reed, King Khalid Univ; CD4 T cell expression cloning SG Webb, JR Univ Fed Bahia; Univ Ottawa Identification and cloning of snake venom Junqueira-de-Azevedo, IDL da vascular endothelial growth Silva, MB Chudzinski-Tavassi, factor (svVEGF) from Bothrops AM Ho, PL erythromelas pitviper

Título Autores Instituição Univ Fed Ouro Preto; Univ Fed Parana; Identification and molecular cloning of insecticidal de Castro, CS Silvestre, FG Araujo, Embrapa Milho & toxins from the venom of the brown spider SC Yazbeck, GD Mangili, OC Cruz, I Sorgo; Loxosceles intermedia Chavez-Olortegui, C Kalapothakis, E Univ Fed Minas Gerais ARRUDA, LK ESCOLA PAULISTA IDENTIFICATION OF BLOMIA-TROPICALIS FERNANDEZCALDAS, E NASPITZ, MED; ALLERGEN BLO-T-5 BY CDNA CLONING CK MONTEALEGRE, F VAILES, LD UNIV S FLORIDA; CHAPMAN, MD PONCE SCH MED Infestin, a thrombin inhibitor presents in Triatoma Campos, ITN Amino, R Sampaio, UNIFESP; infestans midgut, a Chagas' disease vector: gene CAM Auerswald, EA Friedrich, T Klinikum Univ Munich; cloning, expression and characterization of the Lemaire, HG Schenkman, S Tanaka, BASF AG inhibitor AS Univ Sao Paulo; Isolation and cloning of Streptomyces terminal Stoll, A Horvat, LI Lopes-Shikida, Univ Kaiserslautern; fragments SAR Padilla, G Cullum, J Inst Technol Res Sao Paulo State IPT Rockefeller Univ; Natl Univ Ireland Univ Coll Dublin; Isolation, cloning, and complete nucleotide Lewis, MJ Novoa, P Ishak, R Ishak, Emilio Ribas Inst sequence of a phenotypically distinct Brazilian M Salemi, M Vandamme, AM Infect Dis; isolate of human T-lymphotropic virus type II Kaplan, MH Hall, WW Katholieke Univ (HTLV-II) Leuven; Fed Univ Para; N Shore Univ Hosp NIAID; Fiocruz MS; UNIV ALABAMA; UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED; GEORG SPEYER HAUS; Gao, F Morrison, SG Robertson, DL WHO; Thornton, CL Craig, S Karlsson, G NATL AIDS Sodroski, J Morgado, M CONTROL GalvaoCastro, B vonBriesen, H PROGRAM; Beddows, S Weber, J Sharp, PM Dana Farber Canc Shaw, GM Hahn, BH Osmanov, S Inst; Heyward, WL Esparza, J INST TROP MED; vandePerre, P Karita, E Sempala, S UGANDA VIRUS RES Tugume, B Biryahwaho, B Wasi, C INST; RubsamenWaigmann, H Holmes, H MAHIDOL UNIV; Molecular cloning and analysis of functional Newberry, A Ranjbar, S Tomlinson, NATL INST BIOL envelope genes from human immunodeficiency P Bradac, J Mullins, JI Delwart, EL STAND & virus type 1 sequence subtypes A through G CheingsongPopov, R Kaleebu, P CONTROLS; Myers, G Korber, BTM Chiphangwi, LOS ALAMOS NATL J Taha, T Desormeaux, J LAB; Eiumtrakul, S Natpratan, C MALAWI COLL MED; Khamboonruang, C Miotti, P Halsey, CTR DEV & SANTE; NA Vlahov, D Nelson, KE Phair, J ROYAL THAI ARMY Cao, Y Moore, JP Ho, DD Matocha, HOSP; M Fowler, A Dilworth, S Sharma, O ROYAL THAI MINIST Brown, R Dusing, S Whitman, J PUBL HLTH; Hoekzema, D Vogel, F CHIANG MAI UNIV; JOHNS HOPKINS UNIV; NORTHWESTERN UNIV; AARON DIAMOND AIDS RES CTR; Univ Nottingham; Univ Washington

Título Autores Instituição Molecular cloning and biochemical Ghaddar, G Ruchon, AF characterization of a new mouse testis Carpentier, M Marcinkiewicz, M Univ Montreal; soluble-zinc-metallopeptidase of the Seidah, NG Crine, P Univ Fed Ceara neprilysin family Desgroseillers, L Boileau, G Molecular cloning and characterization of a Santos, MO Pereira, M Felipe, cDNA encoding the N-acetyl-beta-D- Univ Fed Goias; MSS Jesuino, RSA Ulhoa, CJ glucosaminidase homologue of Univ Brasilia Soares, RDA Soares, CMD Paracoccidioides brasiliensis Molecular cloning and characterization of a Jesuino, RSA Pereira, M Felipe, Univ Fed Goias; cDNA encoding the Paracoccidioides MSS Azevedo, MO Soares, CMA Univ Brasilia brasiliensis l35 ribosomal protein Univ Fed Rio Molecular cloning and characterization of a Bartholomeu, DC Batista, JAN Grande Sul; gene encoding the 29-kDa proteasome Vainstein, MH Lima, BD de Sa, Univ Brasilia; subunit from Trypanosoma cruzi MC Univ Fed Minas Gerais Molecular cloning and characterization of a glucan synthase gene from the human Pereira, M Felipe, MSS Brigido, Univ Fed Goias; pathogenic fungus Paracoccidioides MM Soares, CMA Azevedo, MO Univ Brasilia brasiliensis Fiocruz MS; TIERARZTLICHEN HSCH Molecular cloning and characterization of Grangeiro, TB Schriefer, A HANNOVER; ConBr, the lectin of Canavalia brasiliensis Calvete, JJ Raida, M Urbanke, C PEPTID FORSCH seeds BarralNetto, M Cavada, BS GMBH; HANNOVER MED SCH; Univ Fed Ceara Cardoso, FC Pacifico, LG Carvalho, Molecular cloning and characterization of DC Victoria, JMN Neves, ALG Univ Fed Minas Phoneutria nigriventer toxins active on calcium Chavez-Olortegui, C Gomez, MV Gerais channels Kalapothakis, E Molecular cloning and characterization of the DNA Augusto-Pinto, L Bartholomeu, DC Univ Fed Minas mismatch repair gene class 2 from the Teixeira, SMR Pena, SDJ Machado, Gerais Trypanosoma cruzi CR Pedrosa, MD de Azevedo, ID Univ Sao Paulo; Molecular cloning and expression of a functional Goncalves-de-Andrade, RM van den Inst Butantan; dermonecrotic and haemolytic factor from Berg, CW Ramos, CRR Ho, PL Univ Wales Coll Loxosceles laeta venom Tambourgi, DV Cardiff Molecular cloning and expression of a functional snake venom vascular endothelium growth factor Junqueira de Azevedo, ILM Farsky, Univ Sao Paulo; (VEGF) from the Bothrops insularis pit viper - A SHP Oliveira, MLS Ho, PL Inst Butantan new member of the VEGF family of proteins Univ Fed Rio de Molecular cloning and expression of bothrojaracin, Arocas, V Castro, HC Zingali, RB Janeiro; a potent thrombin inhibitor from snake venom Guillin, MC Bon, C Wisner, A INST PASTEUR; UNIV PARIS 07 Molecular cloning and expression of structural Assakura, MT Silva, CA Mentele, R Inst Butantan; domains of bothropasin, a P-III metalloproteinase Camargo, ACM Serrano, SMT Univ Munich from the venom of Bothrops jararaca Molecular cloning and expression of the potent Arocas, V JandrotPerrus, M Zingali, INST PASTEUR; thrombin inhibitor bothrojaracin RB Guillin, MC Bon, C Wisner, A UFRPJ ESCOLA PAULISTA MED; MAX DELBRUCK Pesquero, JB Pesquero, JL Oliveira, CTR MOLEC MED; Molecular cloning and functional characterization SM Roscher, AA Metzger, R Ganten, CELL CONTROL of a mouse bradykinin B1 receptor gene D Bader, M BIOMED LABS; Univ Munich; Univ Fed Minas Gerais

Título Autores Instituição Fdn Ezequiel Dias; Molecular cloning and genomic analysis of Guatimosim, SC Prado, VF Diniz, Univ Fed Parana; TsNTxp: an immunogenic protein from Tityus CR Chavez-Olortegui, C Univ Fed Minas serrulatus scorpion venom Kalapothakis, E Gerais Molecular cloning and sequencing of salivary Sant Anna, MRV Araujo, JGVC Fiocruz MS; gland-specific cDNAs of the blood-sucking Pereira, MH Pesquero, JL Univ Fed Minas bug Triatoma brasiliensis (Hemiptera : Diotaiuti, L Lehane, SM Lehane, Gerais; Reduviidae) MJ Univ Wales Molecular cloning and sequencing of the cDNA for rat mesenteric arterial bed Santos, CF Oliveira, EB Salgado, Univ Sao Paulo; elastase-2, an angiotensin II-forming MCO Greene, AS Med Coll Wisconsin enzyme Molecular cloning and structural Grangeiro, TB Nogueira, NAP UFC; characterization of conBr, the lectin of Schriefer, A Calvete, JJ TIERARZTLICHEN Canavalia brasiliensis seeds BarralNetto, M Cavada, BS HSCH HANNOVER Univ Brasilia; Molecular cloning of a cysteine proteinase Neto, OBD Batista, JAN Rigden, Embrapa Recursos cDNA from the cotton boll weevil DJ Franco, OL Fragoso, RR Genet & Biotecnol; Anthonomus grandis (Coleoptera : Monteiro, ACS Monnerat, RG Univ Catolica Curculionidae) Grossi-De-Sa, MF Brasilia Molecular cloning of a gamma- Fortes-Dias, CL Barcellos, CJ phospholipase A(2) inhibitor from Lachesis FUNED Estevao-Costa, MI muta muta (the bushmaster snake) Univ Brasilia; Molecular cloning of alpha-amylases from Oliveira-Neto, OB Batista, JAN Embrapa Recursos cotton boll weevil, Anthonomus grandis and Rigden, DJ Franco, OL Falcao, R Genet & Biotecnol; structural relations to plant inhibitors: An Fragoso, RR Mello, LV dos Univ Catolica approach to insect resistance Santos, RC Grossi-de-Sa, MF Brasilia; EMBRAPA Algodao Penaforte, CL Prado, VF Prado, Molecular cloning of cDNAs encoding MAM Romano-Silva, MA Univ Fed Minas insecticidal neurotoxic peptides from the Guimaraes, PEM De Marco, L Gerais spider Phoneutria nigriventer Gomez, MV Kalapothakis, E Molecular cloning of exons II and III of the alpha-globin major gene from Acedo, MDP Paranhos-Baccala, UFMG Odontophrynus americanus 2n and 4n G Denoya, CD Ruiz, IRG (Amphibia, Anura) Molecular cloning of Neurospora crassa de Paula, R Terenzi, HF UNESP; glycogen synthase Bertolini, MC USP Molecular cloning of the neutral trehalase Katholieke Univ gene from Kluyveromyces lactis and the Amaral, FC VanDijck, P Nicoli, Leuven; distinction between neutral and acid JR Thevelein, JM Univ Fed Minas trehalases Gerais Inst Canc Res; Willis, TG Zalcberg, IR Coignet, Inst Nacl Canc; Molecular cloning of translocation LJA Wlodarska, I Stul, M Ctr Reg Transfus t(1;14)(q21;q32) defines a novel gene Jadayel, DM Bastard, C Sanguine & Genet (BCL9) at chromosome 1q21 Treleaven, JG Catovsky, D Silva, Humaine; MLM Dyer, MJS Katholieke Univ Leuven Willis, TG Zalcberg, IQ Jadayel, Inst Canc Res; Molecular cloning of translocation D Coignet, LJA Stul, M Inst Nacl Canc; t(1;14)(q21;q32) defines a novel gene Treleaven, JG Catovsky, D Katholieke Univ (BCL9) at chromosome 1q21. Wlodarska, I Silva, MLM Dyer, Leuven MJS Molecular cloning, characterization and Izacc, SMS Gomez, FJ Jesuino, Univ Cincinnati; expression of the heat shock protein RSA Fonseca, CA Felipe, MSS Univ Fed Goias; 60 gene from the human pathogenic fungus Deepe, GS Soares, CMA Univ Brasilia Paracoccidioides brasiliensis

Título Autores Instituição Fdn Oswaldo Molecular cloning, characterization, and Cruz; Zancope-Oliveira, RM Reiss, E expression of the M antigen of Histoplasma Ctr Dis Control & Lott, TJ Mayer, LW Deepe, GS capsulatum Prevent; Univ Cincinnati Molecular cloning, expression analysis and Lorenzini, DM Fukuzawa, AH da cellular localization of gomesin, an anti- Univ Sao Paulo; Silva, PI Machado-Santelli, G microbial peptide from hemocytes of the Inst Butantan Bijovsky, AT Daffre, S spider, Acanthoscurria gomesiana Molecular cloning, expression and Kalapothakis, E Araujo, SC de Univ Fed Parana; immunological properties of LiD1, a protein Castro, CS Mendes, TM Gomez, UFMG; from the dermonecrotic family of, Loxosceles MV Mangili, OC Gubert, IC Univ Fed Minas intermedia spider venom Chavez-Olortegui, C Gerais Tambourgi, DV Pedrosa, MDF Molecular cloning, expression, function and van den Berg, CW Goncalves- Inst Butantan; immunoreactivities of members of a gene de-Andrade, RM Ferracini, M Univ Wales Coll family of sphingomyelinases from Loxosceles Paixao-Cavalcante, D Morgan, Cardiff venom glands BP Rushmere, NK Molecular cloning, purification and Univ Fed Rio de immunological responses of recombinants Lemos, JAC Burne, RA Castro, Janeiro; GroEL and DnaK from Streptococcus ACD Univ Rochester pyogenes Bluhm, APC Toledo, RA Univ Sao Paulo; Molecular cloning, sequence analysis and Mesquita, FM Pimenta, MT Butantan Inst; expression of the snake follicle-stimulating Fernandes, FMC Ribela, MTCP Univ Fed Sao hormone receptor Lazari, MFM Paulo MOLECULAR-CLONING AND SEQUENCE- OKLAHOMA ANALYSIS OF CDNAS FOR STATE UNIV; METALLOPROTEINASES FROM BROAD- DEARAUJO, HSS OWNBY, CL UNIV FED SAO BANDED COPPERHEAD AGKISTRODON CARLOS CONTORTRIX LATICINCTUS Monofunctional catalase P of Moreira, SFI Bailao, AM Paracoccidioides brasiliensis: identification, Barbosa, MS Jesuino, RSA Univ Fed Goias; characterization, molecular cloning and Felipe, MSS Pereira, M de Univ Brasilia expression analysis Almeida Soares, CM Barros, EVSA Bataus, LAM Novel cloning system for direct screening Valencia, FF Maranhao, AQ Univ Brasilia using a suicidal strategy Astolfi, S Purification of a cysteine proteinase from Carica candamarcensis L. and cloning of a Pereira, MT Lopes, MTP Meira, Univ Fed Minas genomic putative fragment coding for this WO Salas, CE Gerais enzyme Purification, characterization, and cloning of a serine proteinase inhibitor Azzolini, SS Santos, JMC Souza, EPM; from the ectoparasite AF Torquato, RJS Hirata, IY Embrapa Gado Haematobia irritans irritans (Diptera : Andreotti, R Tanaka, AS Corte Muscidae) Arand, M Golubev, AM Neto, Russian Acad Sci; JRB Polikarpov, I Wattiez, R Univ Mainz; Purification, characterization, gene cloning Korneeva, OS Eneyskaya, EV Natl Synchrotron and preliminary X-ray data of the exo- Kulminskaya, AA Shabalin, KA Light Lab; inulinase from Aspergillus awamori Shishliannikov, Univ Mons; SM Chepurnaya, Voronesh State OV Neustroev, KN Technol Acad Biomed Ctr; Purification, cloning, and expression of the Univ Chile; mitochondrial malate dehydrogenase Aguero, F Noe, G Hellman, U Univ Fed Rio (mMDH) from protoscolices of Echinococcus Repetto, Y Zaha, A Cazzulo, JJ Grande Sul; granulosus Univ Nacl Gen San

Título Autores Instituição Martin Purification, molecular cloning, and properties of a beta-glycosidase isolated Ferreira, AHP Marana, SR Terra, Univ Sao Paulo from midgut lumen of Tenebrio molitor WR Ferreira, C (Coleoptera) larvae Lodes, MJ Dillon, DC Mohamath, R Day, CH Benson, DR Serological expression cloning and Reynolds, LD McNeill, P immunological evaluation of MTB48, a novel Sampaio, DP Skeiky, YAW Mycobacterium tuberculosis antigen Badaro, R Persing, DH Reed, SG Houghton, RL Simplified, rapid method for cloning of virus- binding polypeptides (putative receptors) via Medeiros, RB Rasochova, L Univ Brasilia; the far-Western screening of a cDNA German, TL Univ Wisconsin expression library using purified virus particles Synthesis of cholera toxin B subunit gene: Areas, APD de Oliveira, MLS Univ Sao Paulo; cloning and expression of a functional 6XHis- Ramos, CRR Sbrogio-Almeida, Inst Butantan tagged protein in Escherichia coli ME Raw, I Ho, PL Infect Dis Res Inst; T cell expression cloning of a Mycobacterium Skeiky, YAW Ovendale, PJ Jen, Corixa Corp; tuberculosis gene encoding a protective S Alderson, MR Dillon, DC Med Sch Itajuba; antigen associated with the early control Smith, S Wilson, CB Orme, IM Colorado State infection Reed, SG Campos-Neto, A Univ; Univ Washington The DapA gene encoding the lysine biosynthetic enzyme dihydrodipicolinate Dante, RA Neto, GC Leite, A Univ Estadual synthase from Coix lacryma-jobi: cloning, Yunes, JA Arruda, P Campinas characterization, and expression analysis The Metarhizium anisopliae trp1 gene: Staats, CC Silva, MSN Pinto, PM Univ Fed Rio Cloning and regulatory analysis Vainstein, MH Schrank, A Grande Sul THE MOLECULAR-CLONING OF A PHOSPHOLIPASE A(2) FROM MOURADASILVA, AM PAINE, Fdn Ezequiel Dias; BOTHROPS-JARARACUSSU SNAKE- MJI DINIZ, MRV THEAKSTON, Inst Butantan; VENOM - EVOLUTION OF VENOM RDG CRAMPTON, JM UNIV LIVERPOOL GROUP-II PHOSPHOLIPASE A(2)S MAY IMPLY GENE DUPLICATIONS The use of the replicating pDblet plasmid as Univ Fed a cloning vector with enhanced stability in de Souza, CG de Morais, MA Pernambuco Kluyveromyces marxianus Trypanosoma cruzi: Cloning and Leal, ST Araripe, JR Urmenyi, TP UFRJ; characterization of a RAB7 gene Cross, GAM Rondinelli, E Rockefeller Univ Univ Fed Rio de Janeiro; Yamada-Ogatta, SF Motta, MC Inst Biol Mol Trypanosoma cruzi: cloning and Toma, HK Monteiro-Goes, V Parana; characterization of two genes whose Avila, AR Muniz, BD Nakamura, Univ Estadual expression is up-regulated in metacyclic C Fragoso, SP Goldenberg, S Londrina; trypomastigotes Krieger, MA Fiocruz MS; Univ Estadual Maringa Trypanosoma cruzi: Isolation of an Matsumoto, TK Cotrim, PC da immunodominant peptide of TESA Univ Sao Paulo; Silveira, JF Stolf, AMS (trypomastigote excreted-secreted antigens) UNIFESP Umezawa, ES by gene cloning Use of cDNA cloning to study the mechanism Armelin, MCS Sasahara, RM of action of glucocorticoid hormones at the Flatschart, R Vedoy, C molecular level

b. Stem Cells

Título Autores Instituição Adiposed derived stem cells seeded on the collagen matrix a new exciting option Almeida, FG Schor, N Leite, K Srougi, Univ Fed Sao for tissue engineering M Bruschini, H Paulo reconstruction of the lower urinary tract Age-related changes of P-glycoprotein- mediated rhodamine 123 Univ Sao Paulo; Calado, RT Machado, CG Carneiro, JJ efflux in normal human bone Blood Ctr Garcia, AB Falcao, RP marrow hematopoietic Pernambuco stem cells Univ Sao Paulo; Univ Estadual Campinas; Sao Jose do Rio De Souza, CA Ruiz, MA Vigorito, AC Preto Med Sch; Allogeneic haematopoietic stem cell Aranha, FJP Zulli, R Miranda, ECM Univ Fed Minas transplantation - EBMT risk score Dulley, FL Tabak, D Azevedo, AM Gerais; evaluation for 1084 CML patients Byington, R Azevedo, WM Silla, L Univ Fed Rio transplanted in Brazil Maiolino, A Nucci, M Voltarelli, JC Grande Sul; Colturato, V De Souza, MP Pasquini, R Univ Fed Rio de Janeiro; Jau Ctr Hosp; Univ Fed Parana Allogeneic peripheral blood stem cell versus bone marrow transplantation for Univ Fed Minas chronic myeloid leukemia: Azevedo, WM Fagundes, EM Lodi, FM Gerais; A comparative study from state university Vigorito, AC Souza, CA State Univ of campinas (UNICAMP) and federal Campinas university of minas gerais (UFMG), Brazil. Hop St Louis; Hammersmith Hosp; Huddinge Hosp; St Laszlo Hosp; Osped Civile; Osped San Martino Genova; Guardiola, P Socie, G Pasquini, R Dept Hematol; Dokal, I Ortega, JJ van Weel-Sipman, Univ Catholique M Marsh, J Locatelli, F Souillet, G Louvain; Cahn, JY Ljungman, P Miniero, R Allogeneic stem cell transplantation for Hosp M Infantil Shaw, J Vermylen, C Archimbaud, E Fanconi anaemia Vall Hebron; Bekassy, AN Krivan, G Di Bartolomeo, Univ Leiden P Bacigalupo, A Gluckman, E CA Hosp; Severe Aplastic Anaemia Working Univ Pavia; Party; EBMT; EUFAR Hop Debrousse; Hop Jean Minjoz; Univ Turin; Royal Alexandra Hosp Children; Hop Edouard Herriot; Univ Lund

Título Autores Instituição Allogeneic transplantation for hematological malignancies using G- Azevedo, WM Aranha, FJP Gouvea, JV CSF mobilized, non cryopreserved, Vigoritto, AC Marques, JFC Eid, KAB UNICAMP unmanipulated peripheral blood stem Azevedo, AM Barbosa, KB Souza, CA cells ALLOGENEIC TRANSPLANTATION FOR HEMATOLOGICAL AZEVEDO, WM ARANHA, FJP MALIGNANCIES USING G-CSF GOUVEA, JV VIGORITTO, AC UNICAMP MOBILIZED, NONCRYOPRESERVED, MARQUES, JFC EID, KAB AZEVEDO, UNMANIPULATED PERIPHERAL- AM SOUZA, CA COSTA, FF BLOOD STEM-CELLS Allogeneic transplantation for Azevedo, WM Aranha, FJ Gouvea, JV hematological malignancies using rhG- Vigorito, AC Marques, JFC Eid, KAB CSF mobilized blood stem cells Azevedo, AM Barbosa, KB Souza, CA ALLOGENEIC TRANSPLANTATION AZEVEDO, WM ARANHA, FJP WITH BLOOD STEM-CELLS GOUVEA, JV VIGORITO, AC

MOBILIZED BY RHG-CSF FOR MARQUES, JFC EID, KAB AZEVEDO, HEMATOLOGICAL MALIGNANCIES AM SOUZA, CA Amniotic membrane transplantation for Gomes, JAP dos Santos, MS Cunha, Univ Fed Sao partial and total limbal stem cell MC Mascaro, VLD Barros, JDN de Paulo deficiency secondary to chemical burn Sousa, LB Applications of flow cytometry to Univ Sao Paulo; Voltarelli, JC hematopoietic stem cell transplantation Scripps Res Inst Fed Univ Rio De Are autologous bone marrow Assad, JA Silva, GV Perin, EC Janeiro; mononuclear stem cell injections a Dohmann, HF Silva, SA Sousa, AL Texas Heart Inst; trigger for malignant ventricular Borojevic, R Vaughn, WK Dohmann, HJ Hosp arrhythmias? Mesquita, E Procardiaco Autologous hematopoietic stem cell Voltarelli, JC Oliveira, MCB Stracieri, transplantation for Takayasu's arteritis: ABPL Godoi, DF Moraes, DA Coutinho, Univ Sao Paulo Report of the first case of the literature MA Silva, RL Soussain, C Massumoto, C Autologous peripheral blood stem cells Macedo, MCA Medeiros, RSS Dzik, C Univ Sao Paulo; transplantation (APSBcT) as an Rocha, IF Silva, ACM Loterio, HA FUNDACAO outpatient basis. Experience of a Diomede, BB Franca, GG Ostronoff, M PROSANGUE Brazilian center. Machado, CM DorlhiacLlacer, P HEMOCTR Chamone, DAF Dulley, F Autologous stem cell transplantation (ASCT) for multiple myeloma followed by Oliveira, JSR Cecyn, KZ Faria, RMD Hosp Santa immunomodulation with interferon-2 Parisio, K Ribeiro, APMR Gomes, LS Marcelina alpha (IFN-2 alpha) and interleukin-2 (IL- Juliane, JMF Raineri, G 2). Autologous stem cell transplantation for relapsed/refractory Lerner, D Tavares, RB De Lima, MG Hodgkin's disease using Bouzas, LF Da Matta, JR Melo, T Inst Nacl Canc Cyclophosphamide, Etoposide, BCNU Byington, R Tabak, D and +/- Platinum. Univ Fed Sao Paulo; Hosp Clin; Castro, CG Seber, A Mendes, W Autologous stem cell transplantation for Hosp AC Castro, HC Borsato, ML Gregianin, LJ the treatment of pediatric solid tumors in Camargo Fund Ginani, VC Barros, JCA Petrilli, AS Brazil Antonio Brunetto, AL Prudente; Santa Casa de Sao Paulo Busulfan plus melfalan in autologous Massumoto, C Mizukami, S Campos, Ctr Oncol Sirio blood stem cell transplantation for MF Silva, L Graziani, S Libanes multiple myeloma (MM).

Título Autores Instituição CD25 expression on donor CD4(+) or MD Anderson Stanzani, M Martins, SLR Saliba, RM CD8(+) T cells is associated with an Canc Ctr; John, LSS Bryan, S Couriel, D increased risk for graft-versus-host Univ Bologna; McMannis, J Champlin, RE Molldrem, disease after HLA-identical stem cell Fleury Diagnost JJ Komanduri, KV transplantation in humans Med Ctr CD34+cells from bone marrow, peripheral blood stem cell collection and Lemos, MM Voltarelli, JC Covas, DT umbilical cord blood: Quantitative Hemocentro Zago, MA Palma, P Orellana, M analysis at Hemocentro de Ribeir? Preto- USP-BRAZIL CPQ; Child with Philadelphia positive (Ph plus Hassan, R Otazu, IB Ornellas, MH INCa; )-acute leukemia with myeloid Pires, V Carrico, MK Seuanez, HN CEMO; morphology: One case of stem cell origin Tabak, DG Zalcberg, IR Univ Fed Rio de Janeiro Chronic graft-versus-host disease after Azevedo, AM Correa, MEP Vigorito, AC allogeneic transplants with peripheral Aranha, FJP Eid, KAB Cintra, ML UNICAMP blood stem cells or bone marrow: A Souza, CA Azevedo, WM comparative study. CMV infection surveillance with nested- PCR and antigenemia assays in patients Bonon, SHA Rossi, CL De Souza, CA who received or not ganciclovir universal UNICAMP Vigorito, AC Costa, SCB prophylaxis in HLA identical sibling hematopoietic stem cell transplants. Combined use of hematopoietic Hamerschlak, N Bacal, N Feitosa, A peripheral blood stem cells and bone ALBERT Ferreira, E Gansl, R Katz, A Marti, L marrow treated in vitro with mafosfamide EINSTEIN COLL Rosenfeld, L Pasternak, J Simon, S in patients with acute myeloid leukemia MED HOSP Szterling, L Tabakof, J at first remission. Comparative analysis of the outcomes in allogeneic peripheral blood stem cell or Azevedo, AM Eid, KAB Aranha, FJP bone marrow transplants in patients with Vigorito, AC Correa, MEP Regazzo, JT UNICAMP hematological malignancies: A follow-up Souza, CA Azevedo, WM study of forty seven patients. Comparison of gene expression of Panepucci, RA Siufi, JL Silva, WA mesenchymal stem cells from the Univ Sao Paulo; Proto-Siqueira, R Rocha, V Covas, DT umbilical cord and from the bone Hop St Louis Zago, MA marrow. Correlation of mixed lymphocyte culture Visentainer, JEL Lieber, SR Persoli, with chronic graft-versus-host disease LBL Lima, SCBD Vigorito, AC Aranha, Univ Estadual following allogeneic stem cell FJP Eid, KAB Oliveira, GB Miranda, Campinas transplantation ECM de Souza, CA Could the coculture of skeletal myoblasts Carvalho, KAT Guarita-Souza, LC and mesenchymal stem cells be a Rebelatto, CLK Senegaglia, AC Pontificia Univ solution for postinfarction myocardial Hansen, P Mendonca, JGR Cury, CC Catolica Parana scar? Francisco, JC Brofman, PRS Dexamethasone-mediated down- regulation of stem cell factor in murine Brito, JM Mermelstein, CS Tempone, Fed Univ Rio De hepatic stellate cells is inhibited by mast AJ Borojevic, R Janeiro cells IBUSP; Differentiation of mouse embryonic stem Mittmann, J Kerkis, I Kawashima, C Univ Estadual cells and their hybrids during embryoid Sukoyan, M Santos, E Kerkis, A Norte body formation Fluminense DMSO removal reduces stem-cell Oliveira, OMW Vieira, MJ Bastos, infusion-related toxicity and allows Univ Fed Sao EMSC Delbuono, E Ginani, VC Gordan, excellent engraftment of cryopreserved Paulo; L Gouveia, RV Cecyn, KZ Carvalho, ML unrelated cord blood and autologous UNIFESP Lee, MLM Petrilli, AS Seber, A stem cells

Título Autores Instituição Engraftment syndrome following autologous hematopoietic stem cell Maiolino, A Biasoli, I Lima, J Portugal, Univ Fed Rio de transplantation: definition of diagnostic AC Pulcheri, W Nucci, M Janeiro criteria Establishment of new murine embryonic stem cell lines for the generation of Sukoyan, MA Kerkis, AY Mello, MRB Univ Sao Paulo mouse models of human genetic Kerkis, IE Visintin, JA Pereira, LV diseases Evaluation of minimal residual disease in Pagnano, KBB Vigoritto, AC Aranha, CML patients post allogeneic bone FJP Costa, FF Saad, STO Lorand- UNICAMP marrow (BM) or peripheral blood stem Metze, I Oliveira, GB Eid, KAB Miranda, cells transplantation (PBSC). ECM De Souza, CA Feasability of peripheral blood stem cell Seber, A Ginani, VC Cecyn, K Morais, (PBSC) collections in children with stage MF Luppi, LA Seixas, MT Toledo, SR UNIFESP IV neuroblastoma after >= 6 cycles of Petrilli, AS Rizzo, MF Caran, EM chemotherapy Feasibility of peripheral blood stem cell Seber, A Ginani, VC Cecyn, K Morais, (PBSC) collections in children with stage MFC Luppi, LAGS Seixas, MT Toledo, Univ Fed Sao IV neuroblastoma after >= 5 cycles of SRC Cruz, GAL Petrilli, AS Rizzo, MFV Paulo chemotherapy (CHT). Caran, EMM Univ Hosp Fed Rio De Janeiro; Univ Hosp Fed Parana; State Univ Hosp Campinas; Nucci, M Marr, KA Queiroz-Telles, F State Univ Hosp Fusarium infection in hematopoietic stem Martins, CA Trabasso, P Costa, S Sao Paulo; cell transplant (HSCT) recipients. Voltarelli, JC Colombo, AL Carter, RA Univ Hosp Fed Pasquini, R De Souza, C Anaissie, EJ Sao Paulo; Inst Nacl Canc; Fred Hutchinson Canc Res Ctr; Univ Arkansas Med Sci Univ Sao Paulo; Univ Fed Sao Paulo; Univ Estadual Nucci, M Marr, KA Queiroz-Telles, F Campinas; Martins, CA Trabasso, P Costa, S Fed Univ Rio De Fusarium infection in hematopoietic stem Voltarelli, JC Colombo, AL Imhof, A Janeiro; cell transplant recipients Pasquini, R Maiolino, A Souza, CA Inst Nacl Canc; Anaissie, E Fred Hutchinson Canc Res Ctr; Univ Washington; Univ Arkansas; Univ Fed Parana Virginia Glial-guided neuronal migration in Commonwealth Santiago, MF Liour, SS Mendez-Otero, R differentiated P19 embryonal carcinoma (EC) Univ; Yu, RK stem cell aggregates Univ Fed Rio de Janeiro Voltarelli, JC Oliveira, MCB Stracieri, ABPL Haematopoietic stem cell transplantation for Godoi, DF Moraes, DA Coutinho, MA Univ Sao Paulo refractory Takayasu's arteritis Malmegrim, KCR Santos, AC Hematopoietic stem cell transplantation for autoimmune diseases in developing Univ Sao Paulo; Voltarelli, JC Ouyang, J countries: current status and future Nanjing Univ prospectives

Título Autores Instituição Hematopoietic stem cell transplantation in patients with genetic diseases: A new Sales-Bonfim, CM Bitencourt, MA challenge to developing countries. A Moreira, VA Gardin, NE Setubal, DC de UFPR report from a single institution in 39 Medeiros, CR Zanis-Neto, J Pasquini, R patients. Hepatocyte growth factor increases the stem cell factor-dependent maintenence Univ Fed Rio de Brito, JM Borojevic, R of murine mast cells in coculture with Janeiro hepatic stellate cells High-dose chemotherapy and autologous de Castro, CG de Almeida, SG Univ Fed Rio peripheral blood stem cell rescue in a Gregianin, LJ Loss, JF Rivero, LF Grande Sul patient with pleuropulmonary blastoma Schwartsmann, G Brunetto, AL Immunological study of the first cord Vasconcelos, ZFM Diamond, HR Pires, blood stem cell transplantation at the V Souza, MHO Barone, B Silva, MLM Natl Canc Inst Brazilian National Cancer Institute Tabak, DG Bouzas, LFS Rumjanek, VM (INCA). Improvement in MV02 and reversible Silva, GV Perin, EC Dohmann, HF Texas Heart Inst; perfusion defects in candidates for heart Borojevic, R Silva, SA Sousa, AL Univ Fed Rio de transplant after transendocardial injection Assad, JA Vaughn, WK Mesquita, CT Janeiro; of autologous bone marrow derived Belem, L Carvalho, AC Dohmann, HJ Hosp mononuclear stem cells Willerson, JT Procardiaco In vitro and in vivo study of pluripotency Matveeva, NM Shilov, AG in intraspecific hybrid cells obtained by Kaftanovskaya, EM Maximovsky, LP Russian Acad Sci fusion of murine embryonic stem cells Zhelezova, AI Golubitsa, AN with splenocytes Bayborodin, SI Fokina, MM Serov, OL Univ Arkansas Infectious complications in non- Lee, CK Dignani, C Barlogie, B Guido, Med Sci; myeloablative conditioning and T Morris, CL Badros, AZ Cottler-Fox, Hosp Clin Sao allogeneic peripheral blood stem cell MH van Rhee, F Zanagari, M Fassas, A Paulo; transplantation for patients with multiple Anaissie, EJ Univ Maryland; myeloma. Loma Linda Univ Influence of functional MDR1 gene Calado, RT Falcao, RP Garcia, AB Univ Sao Paulo; polymorphisms on P-glycoprotein activity Gabellini, SM Zago, MA Franco, RF FUNDHERP in CD34(+) hematopoietic stem cells Influence of patient characteristics on CD34+yield in large volume stem cell Conti, F Diniz, V Dutra, H Maiolino, A Univ Fed Rio de collection for autologous bone marrow Nogueira, CM Janeiro transplantation Interleukin-2 (IL-2) post high dose Univ Fed Sao Oliveira, JSR Cecyn, KZ Parisio, K chemotherapy mobilized autologous Paulo; Faria, JR Ribeiro, MSS Chauffaille, stem cell transplant (ASCT) for Hosp Santa MDLF Raineri, G hematologic malignancies. Marcelina Lobo, A Hassan, R Pires, V Tavares, R Is it safe for pediatric donors to donate Lerner, D Bouzas, L Bonamino, M Inst Nacl Canc; stem cells (SC) more than once? Zalcberg, I Tabak, D Sampaio, E de FIOCRUZ Lima, M Isolation and culture of umbilical vein Covas, DT Siufi, JLC Silva, ARL Univ Sao Paulo mesenchymal stem cells Orellana, MD Kinetic evaluation of plasma cytokine Stracieri, ABPL Coutinho, MA Paton, EJ levels after hematopoietic stem cell Univ Sao Paulo Cunha, FQ Voltarelli, JC transplantation. Ginani, VC Cecyn, KZ Carvalho, ML Large volume leukapheresis for Caram, E Macedo, CRPD Gordan, LN autologous peripheral blood stem cell Univ Fed Sao Gouveia, RV Bastos, EMSC Delbuono, collection in children weighting less than Paulo E Lee, MLM Oliveira, OMW Vieira, MJ 25 kg Seixas, MT Petrilli, AS Seber, A Large volume stem cell collection Conti, F Diniz, V Dutra, H Maiolino, A Univ Fed Rio de efficiency for patients with low pre Nogueira, CM Janeiro apheresis CD34+counts

Título Autores Instituição Liposomal Daunorubicin (LD) associated with cyclophosphamide for relapsed Ctr Oncol Hosp Massumoto, C Graziani, S hematologic malignancies pre-peripheral Sirio Libanes blood stem cell transplantation (PBSCT). Mast cells can revert dexamethasone- Brito, JM Mermelstein, CS Tempone, Univ Fed Rio de mediated down-regulation of stem cell AJ Borojevic, R Janeiro factor Mobilization of bone marrow cells (Stem cells) by granulocyte-colony stimulating Univ Sao Paulo; factor associated or not with Bocchi, EA Bacal, F Fdn Prodangue intracoronary stem infusion improves Hemocentro exercise capacity and quality of life in severe heart failure Mobilization of bone marrow cells(stem- cells) by granulocyte-colony stimulating Bocchi, E Bacal, F Issa, V Guimaraes, G Univ Sao Paulo; factor: a new hope in the treatment of Esteves, A Ramires, JF Mendroni, A ProSangue severe congestive heart failure patients Chamone, D with heart transplantation indication Moderately ablative chemotherapy, de Lima, M Bonamino, M Vasconcelos, Z hematopoietic stem cell transplantation Diamond, H Zalcberg, I Andrade, C (HST), and prophylactic donor lymphocyte Bouzas, L Matta, J Tavares, R Lerner, D Inst Nacl Canc infusions (DLI) for poor prognosis patients Byington, R Silva, M Carvalho, L Pires, V (pts) with hematological malignancies. Barone, B Maciel, C Tabak, D Multidrug resistance P-glycoprotein is defective in hematopoietic stem cells in Calado, RT Garcia, AB Falcao, RP Univ Sao Paulo aplastic anemia: A pathogenic event? Murine marrow-derived mesenchymal stem Univ Fed Rio cell: isolation, in vitro expansion, and Meirelles, LD Nardi, NB Grande Sul characterization Hematol Oncol Ctr; Inst Hematol; Hop Henri Mondor; Hosp Sant Pau; Hosp Clin Barcelona; Hosp Juan Canalejo; Cordonnier, C Martino, R Trabasso, P Univ Hosp; Held, TK Akan, H Ward, MS Fabian, K Charite Virchow Mycobacterial infection: A difficult and late Ullmann, AJ Wulffraat, N Ljungman, P Klinikum; diagnosis in stem cell transplant recipients Alessandrino, EP Pretnar, J Gmur, J Univ Mainz Hosp; Varela, R Vitek, A Sica, S Rovira, M CA Ankara Univ; European Blood Marrow Transplant G Royal Perth Hosp; St Laszlo Hosp; Het Wilhelmina Childrens Hosp; Huddinge Univ Hosp; Policlin San Matteo; Univ Sacred Heart; Univ Clin Ctr Univ Porto; Univ Minho; Novel and classic myoepithelial/stem cell Reis, JS Milanezi, F Paredes, J Silva, P Salomao & markers in metaplastic carcinomas of the Pereira, EM Maeda, SA de Carvalho, Zoppi breast LV Schmitt, FC Associated Pathol

Título Autores Instituição Univ Hosp; Hosp Civil; Hop St Louis; Hammersmith Hosp; Hosp Maternal Infantil Vall Hebron; Leiden Univ; St George Hosp; Clin Univ St Luc; Royal Victoria Infirm; Guardiola, P Pasquini, R Dokal, I Huddinge Hosp; Ortega, JJ van Weel-Sipman, M Marsh, Osped Regina JCW Ball, SE Locatelli, F Vermylen, C Margherita; Outcome of 69 allogeneic stem cell Skinner, R Ljungman, P Miniero, R New Childrens transplantations for Fanconi anemia Shaw, PJ Souillet, G Michallet, M Hosp; using HLA-matched unrelated donors: a Bekassy, AN Krivan, G Di Bartolomeo, Hosp Debrousse; study on behalf of the European Group P Heilmann, C Zanesco, L Cahn, JY Hosp Edouard for Blood and Marrow Transplantation Arcese, W Bacigalupo, A Gluckman, E Herriot; CA European Grp Blood Marrow; St Laszio Hosp; European Fanconi Anemia Registry Osped Civile; Rigshosp; Clin Oncoematol Pediat; Ctr Leucemie Infantili; Hosp Jean Minjoz; Univ La Sapienza; Osped San Martino Genova; Policlin San Matteo Patient's socioeconomic status Fischer, G Bittencourt, H Grossini, M influencing overall survival and Jochins, A Fogliatto, L Pilati, S H Clin transplant-related mortality after Bittencourt, R Astigarraga, C allogeneic stem cell transplantation Fernandes, F Bittar, C Onsten, T Silla, L Brandao, J Massumoto, CM Gioachini, HOSP ALEMAO Peripheral blood stem cell harvest in R Ochiuso, M Silva, S Sopelete, C OSWALDO haemonetics V50 plus. DePaula, C Ribeiro, M Ruela, M CRUZ Takahashi, K Dulley, F Prophylactic donor lymphocyte infusions de Lima, M Bonamino, M Vasconcelos, after moderately ablative chemotherapy Z Colares, M Diamond, H Zalcberg, I and stem cell transplantation for Tavares, R Lerner, D Byington, R hematological malignancies: high Inst Nacl Canc Bouzas, L da Matta, J Andrade, C remission rate among poor prognosis Carvalho, L Pires, V Barone, B Maciel, patients at the expense of graft-versus- C Tabak, D host disease Prophylactic meropenem during Nucci, M Nouer, SA Garnica, M de Univ Fed Rio de neutropenia in allogeneic stem cell Oliveira, ALM Maiolino, A Janeiro transplant recipients Prospective surveillance of nosocomial infection among allogeneic Fagnani, R Cardoso, LGO Dantas, Univ Estadual haematological stem cell transplant SRPE Leichsenring, ML Carvalho, MCS Campinas recipients stratified by grade of Trabasso, P neutropenia at a teaching hospital

Título Autores Instituição UNIFESP; Quantitative analysis of circulating Sirio Libanes CD34+cells as a guide for peripheral Morais, MC Massumoto, C Mizukami, S HOsp; blood stem cell(PBSC)collections by Luppi, LA Petrilli, A Seber, A Santa Paula leukapheresis Hosp Massumoto, CM Campos, MF Quantitative CD34 analysis used as Mizukami, S Silva, LAG Romani, C Univ Sao Paulo predictors of stem cell harvest. Callera, F Chamone, DF Dulley, F Science, philosophy, religion, and use of Baschetti, R embryonic stem cells - Reply Univ Estadual Campinas; Visentainer, JEL Lieber, SR Persoli, Serum cytokine levels and acute graft- Mackenzie LBL Vigorito, AC Aranha, FJP Eid, KAD versus-host disease after HLA-identical Presbyterian Oliveira, GB Miranda, ECM de Souza, hematopoietic stem cell transplantation Univ; CA Univ Estadual Maringa Stem cell factor plays a major role in the Univ Fed Minas recruitment of eosinophils in allergic Klein, A Talvani, A Cara, DC Gomes, Gerais; pleurisy in mice via the production of KL Lukacs, NW Teixeira, MM Univ Michigan leukotriene B-4 Univ Fed Minas Gerais; Stem cell factor-induced leukotriene B-4 Klein, A Talvani, A Silva, PMR Martins, Fdn Oswaldo production cooperates with eotaxin to MA Wells, TNC Proudfoot, A Luckacs, Cruz; mediate the recruitment of eosinophils NW Teixeira, MM Univ Michigan; during allergic pleurisy in mice Serono Pharmaceut Hosp Sirio Libanes; Massumoto, C Hamerschlack, N Stem cell transplantation (PBSCT) for Hosp Israelita Ferreira, E Pietrocola, M Katz, F Kutner, chronic myelogenous leukemia (CML). Albert Einstein; JM Alves, A Ctr Hemoterapia Sao Lucas Stem cell transplantation (SCT) for patients (pts) with genetic diseases: A Bonfim, CMS Bitencourt, MA Setubal, call for physicians from developing DC Moreira, VA Lorenzato, C Ruiz, J Univ Fed Parana countries to discuss about strategies to Neto, JZ de Medeiros, CR Pasquini, R improve diagnosis and early referral to BMT centers Stem cell transplantation for Fanconi Neto, JZ Bitencourt, MA Bonfim, CMS Fred Hutchinson Anemia: 20 years of progressive Medeiros, CR Moreira, VA Setubal, DC Canc Res Ctr; decrease in the dose of Flowers, MED Pasquini, R Univ Fed Parana cyclophosphamide without irradiation Strongyloidiasis pre and post autologous Schaffel, R Portugal, R Maiolino, A Univ Fed Rio de peripheral blood stem cell transplantation Nucci, M Janeiro Univ Sao Paulo; Inst Nacl Canc; T-lymphocyte function from peripheral blood Vasconcelos, ZFM Santos, BM Costa, ES Univ Fed Minas stem-cell donors is inhibited by activated Lima, M Tabak, DG Bouzas, LF Azevedo, Gerais; granulocytes WM Barcinski, MA Bonomo, A Univ Fed Rio de Janeiro; Univ Texas Th1/Th2 lymphokine profile of T cells present Univ Sao Paulo; in the blood of granulocyte-colony stimulating Vasconcelos, ZFM Diamond, HR Tabak, DG Fed Univ Rio De factor-treated stem-cell donors: up or down Barcinski, MA Bonomo, A Janeiro modulation? The absolute number of circulating CD34(+) Fontao-Wendel, R Lazar, A Melges, S Hosp Sirio cells as the best predictor of peripheral Altobeli, C Wendel, S Libanes hematopoietic stem cell yield

Título Autores Instituição The effect of lead on the bone marrow stem cells of mice infected with Listeria Bincoletto, C Queiroz, MLS UNICAMP monocytogenes Silva, WA Covas, DT Panepucci, RA The profile of gene expression of human Proto-Siqueira, R Siufi, JLC Zanette, DL Fac Med marrow mesenchymal stem cells Santos, ARD Zago, MA The unexpected discovery and toxicity of St Jude pulmonary hypertension after Childrens Hosp; hematopoietic stem cell transplantation Kasow, KA Bonfim, C Asch, J Margolis, Univ Utah; for malignant osteopetrosis: The possible D Jenkins, J Tamburro, RF Horwitz, E Med Coll existence of a genetic link or a Wisconsin; physiologic consequence. Univ Fed Parana Perin, EC Dohmann, HF Borejevic, R Time course of improvement following Silva, SA Sousa, AL Silva, GV Assad, Texas Heart Inst; stem cell injections in humans with heart JA Belem, L Carvalho, AC Esporcatte, Procardiaco failure R Vaughn, WK Dohmann, HJ Willerson, Hosp JT Massumoto, C Moraes, JR Moraes, ME Unrelated peripheral blood stem cell Macedo, MCA Medeiros, R Chamone, transplantation for Fanconi anemia D Dulley, F Inst Nacl Canc; Unrelated umbilical cord blood stem cell Khorshid, O de Meis, E Martin, T Jones, Univ Texas; transplant after failure of haploidentical RB Shpall, EJ Nieto, Y Khouri, I Univ Calif San or matched unrelated donor Shahjahan, M Gajewski, J Giralt, S Francisco; hematopoietic stem cell transplant Champlin, R de Lima, M Univ Colorado Hosp Use of stem cells in creation of embyros Baschetti, R

c. Genômica Funcional

Título Autores Instituição Verjovski-Almeida, S Univ Sao Schistosome transcriptome: insights and perspectives Leite, LCC Paulo; for functional genomics Dias-Neto, E Menck, CFM Univ York; Wilson, RA Inst Butantan

d. Proteômica

Título Autores Instituição Circulating nucleic acids and John Wayne proteomics of plasma/serum - Taback, B Hoon, DSB Canc Inst Clinical utility

Colorado State Continued proteomic analysis Marques, MAM Espinosa, BJ da Silveira, EKX Univ; of Mycobacterium leprae Pessolani, MCV Chapeaurouge, A Perales, J Inst Oswaldo subcellular fractions Dobos, KM Belisle, JT Spencer, JS Brennan, PJ Cruz

Título Autores Instituição

Univ Sao Paulo; Functional post-translational Hosp Sick proteomics approach to study Schachter, H Chen, SH Zhang, WL Spence, AM Children; the role of N-glycans in the Zhu, SX Callahan, JW Mahuran, DJ Fan, XL Univ Toronto; development of Caenorhabditis Bagshaw, RD She, YM Rosa, C Reinhold, AN Burnham Inst; elegans Univ New Hampshire

High-throughput screening of Univ Sao Paulo; Galvao-Botton, LMP Katsuyama, AM Guzzo, CR structural proteomics targets Univ Fed Rio de Almeida, FCL Farah, CS Valente, AP using NMR Janeiro

Proteomic analysis of the Paba, J Santana, JM Teixeira, ARL Fontes, W human pathogen Trypanosoma Univ Brasilia Sousa, MV Ricart, CAO cruzi

Proteomic analysis of the larval stage of the parasite Univ Fed Rio Chemale, G van Rossum, AJ Jefferies, JR Echinococcus granulosus: Grande Sul; Barrett, J Brophy, PM Ferreira, HB Zaha, A Causative agent of cystic Univ Wales hydatid disease

Proteomic analysis of Trypanosoma cruzi Paba, J Ricart, CAO Fontes, W Santana, JM Univ Brasilia; developmental stages using Teixeira, ARL Marchese, J Williamson, B Hunt, T Appl Biosyst Inc; isotope-coded affinity tag Karger, BL Sousa, MV Northeastern Univ reagents

Univ Louisville; Max Delbruck Ctr Proteomic analysis reveals Mol Med; Thongboonkerd, V Gozal, E Sachleben, LR alterations in the renal kallikrein Escola Paulista Arthur, JM Pierce, WM Cai, J Chao, J Bader, M pathway during hypoxia- Med; Pesquero, JB Gozal, D Klein, JB induced hypertension Med Univ S Carolina; Vet Adm Med Ctr Proteomic identification, nucleotide sequence, Univ Brasilia; heterologous expression and Pereira, LA Pereira, M Felipe, MSS Zancope- Fiocruz MS; immunological reactivity of the Oliveira, RM Soares, CMD Univ Fed Goias triosephosphate isomerase of Paracoccidioides brasiliensis

Título Autores Instituição

Appl Biosyst Inc; ULP; Inst Pharmaceut Sci; Univ Montpellier; Binz, PA Abdi, F Affolter, M Allard, L Barblan, J Bruker Dalton Bhardwaj, S Bienvenut, WV Bulet, P Burgess, J Bremen; Carrette, O Corthals, G Delalande, F Diemer, H Spectronex Proteomics application Favreau, P Giuliano, E Gueguen, Y Guillaume, E ThermoFinnigan; exercise of the Swiss Hahner, S Man, P Michalet, S Neri, D Noukakis, FontisMedia; Proteomics Society: Report of D Palagi, P Paroutaud, P Pimenta, DC Quadroni, Ctr Med Univ the SPS'02 session M Resemann, A Richert, S Rybak, J Sanchez, Geneva; JC Scherl, A Scheurer, S Hufnagel, US Siethoff, Applera France; C Suckau, D van Dorsselaer, A Redeker, WW Ctr Appl Toxinol; Walter, N Stocklin, R Nestec Ltd; Univ Hosp Geneva; Univ Lausanne; Atheris Labs

Hemorio; Proteomics in Chronic Myeloid Pizzatti, L Sa, LA Deterling, LC Sousa, JM Univ Fed Rio de Leukemia. Abdelhay, E Janeiro

Univ Fed Rio de Janeiro; Transcriptional, proteomic, and Bro, C Regenberg, B Lagniel, G Labarre, J Tech Univ metabolic responses to lithium Montero-Lomeli, M Nielsen, J Denmark; in galactose-grown yeast cells Ctr Energie Atom Saclay

13. TEMA: SEGURANÇA BIOLÓGICA

Apresenta-se a seguir os títulos dos 9 artigos que têm pelo menos um autor vinculado a uma instituição brasileira, sobre o tema Segurança Biológica, com seus respectivos autores e instituições. Título Autores Instituição

Pardini, LC Biosecurity in x-ray dental equipment: Aluminim or Tin filters? _ Watanabe, PCA

Título Autores Instituição

Passos, DG Galvagni, LG Usage methods of biosecurity in Porto Alegre _ Pires, MM Pires, LAG

Pedrazzi, V An "in vivo" biosafety evaluation of the presence of silica in Panzeri, H _ dentifrices. Fernandes, RR Lara, EHG

Pardini, LC Endodontic: Biosecurity evaluation in X-ray dental equipment. Silva, ABM _ Froner, IC

Capalbo, DMF Hilbeck, A Andow, D Snow, A Bong, BB Wan, FH Brazil and the development of international scientific biosafety Embrapa Fontes, EMG testing guidelines for transgenic crops Environm Osir, EO Fitt, GP Johnston, J Songa, J Heong, KL Birch, ANE

Guare, RO Biosecurity: dentists' kwoledge and attitudes toward personal Zardetto, _ protection. CGDC Ciamponi, AL

Serra, MC Garcia, PPNS Biosafety: analysis of dentists' procedures _ Dotta, EV Matsuzaki, R

Rabello, SB Conduct of dentists regarding biosecurity Godoy, CVC _ Alves, IG

Título Autores Instituição Houw, H Farias, LM Azevedo, VMNN Hamdan, JS Carvalho, MAR Lima, FL Biosafety evaluation in dental offices at UFPI. _ Christofolleti, ARN Lopes, TSP Farias, FF Fialho, AC Macedo, PS Veras, ESL

Em relação aos termos referentes ao tema Segurança Biológica, não foram localizados artigos que contenham pelo menos um autor vinculado a uma instituição brasileira.

14. TEMA: SUSTENTABILIDADE AMBIENTAL

Não foram localizados artigos que contenham especificamente o tema Sustentabilidade Ambiental. Em relação aos termos referentes ao tema Sustentabilidade Ambiental, em um termo (Bioinseticidas) foram localizados artigos publicados por pelo menos um autor vinculado a instituição brasileira. Os títulos dos artigos, seus autores e instituições, são apresentados a seguir.

a. Bioinseticidas

Título Autores Instituição Ferreira, LHPL Molina, JC Evaluation of Bacillus thuringiensis bioinsecticidal Univ Estadual Brasil, C protein effects on soil microorganisms Londrina Andrade, G Darboux, I Pauchet, Y INRA; Loss of the membrane anchor of the target Castella, C Fdn Oswaldo receptor is a mechanism of bioinsecticide Silva-Filha, MH Nielsen- Cruz; resistance LeRoux, C Charles, JF Inst Pasteur Pauron, D Univ Fed Rio Plant toxic proteins with insecticidal properties. A Carlini, CR Grande Sul; review on their potentialities as bioinsecticides Grossi-de-Sa, MF EMBRAPA SCREENING OF BIOINSECTICIDES AGAINST Carranomoreira, AF

THE COTTON BOLLWORM ON COTTON ALL, J

Título Autores Instituição

Evaluation of Bacillus thuringiensis bioinsecticidal Ferreira, LHPL Molina, JC Univ Estadual protein effects on soil microorganisms Brasil, C Andrade, G Londrina Darboux, I Pauchet, Y INRA; Loss of the membrane anchor of the target Castella, C Fdn Oswaldo receptor is a mechanism of bioinsecticide Silva-Filha, MH Nielsen- Cruz; resistance LeRoux, C Charles, JF Inst Pasteur Pauron, D Univ Fed Rio Plant toxic proteins with insecticidal properties. A Carlini, CR Grande Sul; review on their potentialities as bioinsecticides Grossi-de-Sa, MF EMBRAPA SCREENING OF BIOINSECTICIDES AGAINST Carranomoreira, AF ALL, J THE COTTON BOLLWORM ON COTTON Ferreira, LHPL Molina, JC Evaluation of Bacillus thuringiensis bioinsecticidal Univ Estadual Brasil, C protein effects on soil microorganisms Londrina Andrade, G Darboux, I Pauchet, Y INRA; Loss of the membrane anchor of the target Castella, C Fdn Oswaldo receptor is a mechanism of bioinsecticide Silva-Filha, MH Nielsen- Cruz; resistance LeRoux, C Charles, JF Inst Pasteur Pauron, D Univ Fed Rio Plant toxic proteins with insecticidal properties. A Carlini, CR Grande Sul; review on their potentialities as bioinsecticides Grossi-de-Sa, MF EMBRAPA SCREENING OF BIOINSECTICIDES AGAINST Carranomoreira,AF

THE COTTON BOLLWORM ON COTTON ALL, J

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2. Patentes em biotecnologia

Na tabela a seguir estão assinalados os temas/termos de biotecnologia onde foram localizados documentos nos três subconjuntos: patentes relacionadas à Amazônia, patentes relacionadas ao Brasil e patentes depositadas no Brasil. A ocorrência dos termos Amazônia e Brasil no título das patentes trouxe resultados muito limitados e por isso foram consideradas as freqüências destes termos (Amazônia e Brasil) tanto no título como no resumo das patentes. Patentes - Distribuição por temas e termos das Patentes em biotecnologia Relacionados Relacionados Depositadas TEMAS/TERMOS à Amazônia ao Brasil no Brasil TEMA: Biodiversidade/ Bioprospecção Termos da Biodiversidade/ Fitomedicamentos X Bioprospecção TEMA: Bioeconomia X X TEMA: Bioindústria X Termos da Bioprodutos X X Bioindústria Designing X TEMA: Biorremediação X X TEMA: Certificação de qualidade biológica Termos da Certificação de Coleções certificadas X qualidade biológica TEMA: Fertilidade e reprodução animal Termos da Fertilidade e Clonagem X reprodução animal TEMA: Integração: alimentação, nutrição e saúde X X X Nutracêuticos (Alimentos Termos da X Integração: Funcionais) alimentação, Produção de Vacinas em X X X nutrição e saúde Plantas e Animais TEMA: Programas de Descoberta Clonagem X X Termos da Stem Cells X X Programas de Engenharia Genética X X Descoberta Nanobiotecnologia X Proteômica X TEMA: Segurança Biológica X TEMA: Sustentabilidade Ambiental OGMs X Termos da Bioinseticidas X Sustentabilidade Ambiental Biofungicidas X X Controle Biológico X X

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I. Patentes relacionadas com a Amazônia

A tabela a seguir mostra a freqüência de patentes que citam a Amazônia no título e/ou no resumo, para os temas e termos deste estudo.

Relacionados à TEMAS/TERMOS Amazônia TEMA: Bioindústria Termos da Bioindústria Bioprodutos 3 TEMA: Integração: alimentação, nutrição e saúde 1 Termos da Integração: Produção de Vacinas em Plantas e Animais 2 alimentação, nutrição e saúde TEMA: Programas de Descoberta Termos da Programas de Proteômica 1 Descoberta TEMA: Sustentabilidade Ambiental Termos da Sustentabilidade Biofungicidas 1 Ambiental Controle Biológico 1

1. TEMA: BIOINDÚSTRIA

Não foram localizadas patentes que tratem especificamente sobre bioindústria na Amazônia. Em relação aos termos referentes ao tema bioindústria, em um termo (bioprodutos) foram localizadas 3 patentes que referem-se em seu título/resumo à Amazônia, cujos títulos das patentes, resumos, depositantes, números da patentes, países de prioridade e anos de prioridade são apresentados a seguir:

102 a. BIOPRODUTOS

PAÍS ANO NÚMERO DA TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE de de PATENTE PRIOR. PRIOR. TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Immunotherapeutic Agent: The agent of (II) or (IV) further comprise New polypeptide and alumina. In the immunotherapeutic agent of (IV) the Leishmania protozoa WO200274239-A3; immunogenic variants further comprises at least one species selected from L. amazonensis, L. AKIVA LLC (AKIV- WO200274239-A2; comprising amino acid venezuelensis, L. brasilensis, L. chagasi, L. donovani, L. infantum, L. Non-standard); US6673351-B1; sequences of particulate US 2001 major, L. panamensis, L. tropica and L. guyanensis. Alternatively, the ASTRALIS LLC AU2002254097-A1; antigens, useful for the treatment Leishmania consists of a mixture of L. amazonensis, L. venezuelensis, L. (ASTR-Non-standard) EP1458403-A2; and clinical remission of brasilensis and L. chagasi.Preparation: (I) can be prepared by standard JP2004535783-W psoriasis. recombinant techniques including expression and purification from a host cell. NOVELTY - A nucleic acid vaccine vector (I) which is protective against Avian polyomavirus (APV) infection in a bird of the Psittaciformes order is new, and comprises a nucleic acid vector comprising a suitable cis-acting transcription/translation regulatory sequence functionally linked to a nucleic acid encoding an immunogenic APV polypeptide. USE - The vaccines and methods of the invention are used to prevent Avian polyomavirus infection in birds of the Psittaciformes order, Novel vaccines against Avian especially in macaws, Amazon parrots, conures, cockatoos, Pionus WO9956700-A; EP1082011- UNIV GEORGIA RES polyomavirus used for preventing parrots, and African grey parrots (claimed), as well as Budgerigars, A; WO9956700-A2; FOUND INC (UYGE- US 1994 infection in birds of the caiques, courses, Eclectus parrots, cockatiels, and parakeets. AU9939700-A; EP1082011- Non-standard) Psittaciformes order. ADVANTAGE - Prior art methods of vaccinating against Avian A2; US6491921-B1 polyomavirus have been unsuccessful. A need exists for a safe and effective vaccine against Avian polyomavirus which is cross-reactive against the disease in multiple species of Psittaciformes. This need is satisfied by the present invention. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for a method of preventing APV infection in a Psittaciformes bird, comprising administering (I) to the bird. Vaccine for protecting birds of the order Psittaciformes against avian polyomavirus contains a recombinant VP1 capsid protein of an avian Vaccine against avian polyomavirus. UNIV GEORGIA RES polyomavirus in parrots - USE - The vaccine is especially for preventing avian polyomavirus FOUND INC (UYGE- US5747045-A US 1994 containing recombinant VP1 infection in macaws, Amazon parrots, conures, cockatoos, Pionus parrots Non-standard) capsid protein. and African grey parrots (claimed). ADVANTAGE - The vaccine is effective for all Psittaciformes species and does not cause adjuvant related side effects.

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2. TEMA: INTEGRAÇÃO: ALIMENTAÇÃO, NUTRIÇÃO E SAÚDE

Apresenta-se a seguir o título da patente que cita Amazônia no título/resumo, sobre o tema Integração: Alimentação, Nutrição e Saúde, com seu respectivo título, resumo, depositante, número da patente, país de prioridade e ano de prioridade.

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR.

TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: High concentration propolis extract is obtained by irradiating far infrared radiation to container containing propolis immersed in ethanol. Similarly low concentration propolis extract is obtained by irradiating for infra red radiation on comparatively less amount of propolis immersed in ethanol. The low concentration and high concentration propolis extracts are mixed at Extraction of propolis for use in predetermined ratio and propolis extract having predetermined health food, comprises irradiating SHABURON KK concentration. The extraction of high concentration and low concentration JP2001275587- far infrared radiation on propolis (SHAB-Non- JP 2000 propolis extract are performed simultaneously or with a time lack. Preferred immersed in ethanol at low A Active Ingredient: Guarana is Sapindaceae guarana genus, collected from standard) temperature during extraction. Brazil Amazon having catechin as active ingredient for controlling toxicity of beta-amyloid. Maca is a plant of Brassicaceae family containing abundant nutritive in the tap-root and hypocotyl. Maca contains several active components such as alkaloid, steroid, anthocyanin, saponin, terpenoid, etc for producing tonic effect. Catuaba is a plant of Erythroxylon coca which also has a tonic effect.

Em relação aos termos referentes ao tema Integração: Alimentação, Nutrição e Saúde, em um termo (produção de vacinas) foram localizadas patentes que referem-se em seu título/resumo à Amazônia. Os títulos das patentes, resumo, depositante, número da patente, país de prioridade e ano de prioridade são apresentados a seguir:

105 a. PRODUÇÃO DE VACINAS PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. NOVELTY - A nucleic acid vaccine vector (I) which is protective against Avian polyomavirus (APV) infection in a bird of the Psittaciformes order is new, and comprises a nucleic acid vector comprising a suitable cis-acting transcription/translation regulatory sequence functionally linked to a nucleic acid encoding an immunogenic APV polypeptide. USE - The vaccines and methods of the invention are used to prevent Avian polyomavirus infection in birds of the Psittaciformes order, WO9956700-A; Novel vaccines against especially in macaws, Amazon parrots, conures, cockatoos, Pionus EP1082011-A; UNIV GEORGIA RES Avian polyomavirus used for parrots, and African grey parrots (claimed), as well as Budgerigars, WO9956700-A2; FOUND INC (UYGE- US 1994 preventing infection in birds caiques, courses, Eclectus parrots, cockatiels, and parakeets. AU9939700-A; Non-standard) of the Psittaciformes order. ADVANTAGE - Prior art methods of vaccinating against Avian EP1082011-A2; polyomavirus have been unsuccessful. A need exists for a safe and US6491921-B1 effective vaccine against Avian polyomavirus which is cross-reactive against the disease in multiple species of Psittaciformes. This need is satisfied by the present invention. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for a method of preventing APV infection in a Psittaciformes bird, comprising administering (I) to the bird. Vaccine for protecting birds of the order Psittaciformes against avian polyomavirus contains a recombinant VP1 capsid protein of an avian Vaccine against avian polyomavirus. UNIV GEORGIA RES polyomavirus in parrots - USE - The vaccine is especially for preventing avian polyomavirus FOUND INC (UYGE- US5747045-A US 1994 containing recombinant VP1 infection in macaws, Amazon parrots, conures, cockatoos, Pionus Non-standard) capsid protein. parrots and African grey parrots (claimed). ADVANTAGE - The vaccine is effective for all Psittaciformes species and does not cause adjuvant related side effects.

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3. TEMA: PROGRAMAS DE DESCOBERTA

Em relação aos termos referentes ao tema programas de descoberta, em um destes termos (proteômica) foi localizada uma patente que se refere em seu título à Amazônia. O título da patente, resumo, depositante, número da patente, país de prioridade e ano de prioridade são apresentados a seguir.

107 a. PROTEÔMICA

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. NOVELTY - Identifying a molecular target of a cell growth inhibiting compound by:(a) identifying a compound or composition inhibiting growth in a population of cells;(b) performing target prediction processes to identify a modulated gene or gene product; and(c) comparing by target prediction process with the gene or gene product identified by other prediction processes.

USE - The method is used for identifying the molecular target of a cell growth inhibitor. The cells are selected from organisms such as protozoa, bacterium, fungus, ameba and mycoplasma GENOME (claimed). The mycoplasma is selected from Mycoplasma THERAPEUTICS CORP Identification of a pneumoniae, M. fermentans, M. hominis and U. urealyticum. (GENO-Non-standard); molecular target of a cell The fungus is selected form Histoplasma capsulatum, SULAVIK M (SULA- growth inhibitor, WO200216940-A; Coccidioides immitis, Paracoccidioides brasiliensis, Individual); LING L L comprises target WO200216940-A2; Blastomyces dermatitidis, Cryptococcus neoformans, Candida (LING-Individual); US 2000 prediction processes to AU200188360-A; albicans, Candida tropicalis, Candida parapsilosis, Candida OPPERMAN T (OPPE- identify at least one US2003108872-A1 guilliermondii, Candida glabrata, Candida krusei, Candida Individual); MOIR D T modulated gene or gene granuloma, Aspergillus fumigatus, Aspergillus flavus and (MOIR-Individual); product. Aspergillus niger. The protozoa is selected from Entamoeba BUNKER C (BUNK- histolytica, Naegleria fowleri, Plasmodium vivax, Plasmodium Individual) ovale, Plasmodium malariae, Plasmodium falciparum, Babesi microti, Babesi divergens, Leishmania chagasi, Leishmania mexicana, Leishmania amazonensis, Leishmania braziliensis, Leishmania guyanensis, Leishmania panamensis, Leishmania peruviana, Leishmania lainsoni, Leishmania naiffi, Leishmania columbiensis, and Trypanosoma cruzi. The bacterium is gram- positive (such as bacillaceae, micrococcaceae or peptococcaceae) or gram-negative (such as acetobacteriaceae, alcaligenaceae, bacterioidaceae, chromatiaceae.

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4. TEMA: SUSTENTABILIDADE AMBIENTAL

Não foram localizadas patentes que tratem especificamente sobre Sustentabilidade Ambiental relacionadas à Amazônia. Em relação aos termos referentes ao tema bioindústria, em dois termos (Biofungicida e Controle Biológico) foram localizadas patentes que referem-se à Amazônia em seu título/resumo. Os títulos das patentes, resumo, depositante, número da patente, país de prioridade e ano de prioridade são apresentados a seguir:

109 a. BIOFUNGICIDA

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR.

NOVELTY - Preparations containing living micro-organisms useful for the treatment of the soil and plant seeds, are new.

DETAILED DESCRIPTION - Preparations containing living micro-organism(s) which are able to multiply in a certain type of soil, environment of a plant, and are pesticide resistant, comprising cultures of at least one of the following microorganisms: (1) Azospirillum lipoferum ssp. Lip7R885 Improving soil and plant (NCAIM P(B) 001253), (2) Azospirillum amazonese ssp PHYLAXIA PHARMA RT WO9909834-A; seeds micro-organism K21R 887 (NCAIM P(B) 001256), (3) Azospirillum irakense (PHYL-Non-standard); - WO9909834-A2; population - comprises ssp. 5041R 889 (NCAIM P(B) 001125), (4) Azospirillum PHARMA GYOGYSZER HU 1997 HU9701446-A1; preparations containing brasileneses ssp. A41R 879 (NCAIM P(B) 001254), (5) OLTOANYAG & AG AU9889935-A living micro-organisms. Azotobacter vinelandii ssp. ESZ 2132 (NCAIM P(B) 001257), (PHYL-Non-standard) (6) Pseudomonas sp. Szeged 344 O.P. 14 (NCAIM P(B) 001251), (7) Pseudomonas fluorescens var. MOB24, Res24 (NCAIM P(B) 001252), (8) Bacillus circulans var. Res. 97 (NCAIM P(B) 001261), (9) Bacillus mageaterium var. Res. 54 (NCAIM P(B) 001250), (10) Rhizobium meliloti var. PolRes. 7 (NCAIM P(B) 001259), (11) Alcaligenes faecalis var. Res36 (NCAIM P(B) 001260) and (12) Phyll06-R+324 (NCAIM P(B) 001258).

110 b. CONTROLE BIOLÓGICO

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. A microbial inoculant prepn. having auxiliary microbes that enhance the infective activity of infective sources of mycorrhizae, pref. VA mycorrhizae to plants and/or germination of spores and/or elongation of hyphae, contg. infection sources of mycorrhizae, pref. contains an extending agent mixed with the auxiliary microbe and/or the infective sources of mycorrhizae.

Pref. VA mycorrhizae are those of genera Gigaspora, pref. G. margarita, G. albida, Scutellospora, pref. S. gregaria, Glomus, pref. G. fasciculatum, G. etunicatum, Acaulospora, pref. A. laevis, Sclerocystis, pref. S. dussii and/or Entrophospora, pref. E. kinfrequens. Pref. auxiliary microbes are nitrogen-fixing bacteria Inoculation of auxiliary pref. genera Rhizobium pref. R. melitoti, R. trifolii and/or R. legumin microbes to mucorrhizae - osarum, Bradyrhizobium, Azospirillum, pref. A. brasilense, A. promotes water/mineral OSAKA GAS CO liposerum and/or A. amazonense, Azobactera pref. A. JP7231781-A JP 1994 absorption, plant growth, LTD (OSAG) chlorococcum and/or A. vinelandii, Xanthomonas, pref. X. disease/drought resistance maltophila, Xanthobacter, Klebsiella, Enterobacter, pref. E. etc. cloacae, Azomonas, Frankia, Clostridium and/or Cytobacter, phosphate-solubilising microbes, pref. genera Lactobacillus pref. L. acidophilus, Bacillus pref. B. substilis and/or B. polymyxa, Micrococcus, Aspergillus, Fusarium, Escherichia, Flavobacterium, Brevibacterium and/or Aerobacter, plant growth-promoting rooting zone microbes, pref. Pseudomonas, pref. P. fluorescens, P. putida, P. aeruginoas and/or P. chloroaphis and/or Alcaligenes, pref. A. faecalis, antibiotics-producing microbes, pref. general Streptomyces, pref. S. griseus and/or Penicillia and/or mucous fluid-producing microbes pref. genera Myxococcus pref. M. xanthus, Rhodococcus pref. R. erythropolis, Archangium, Cystobacter and/or Polyangium.

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II. Patentes relacionadas com o Brasil

A tabela a seguir mostra a freqüência de patentes que citam Brasil no título ou resumo, para os temas e termos deste estudo.

Relacionados ao TEMAS/TERMOS Brasil RESUMO TEMA: Bioeconomia 72 TEMA: Bioindústria Termos da Bioindústria Bioprodutos 44 TEMA: Biorremediação 1 TEMA: Integração: alimentação, nutrição e saúde 2 Termos da Integração: Produção de Vacinas em Plantas e Animais 11 alimentação, nutrição e saúde TEMA: Programas de Descoberta Clonagem 10 Termos da Programas de Descoberta Stem Cells 2 Engenharia Genética 1 TEMA: Sustentabilidade Ambiental Termos da Sustentabilidade OGMs 2 Ambiental Controle Biológico 10

1. TEMA: BIOINDÚSTRIA

Para este tema não foram localizadas patentes que citam explicitamente o Brasil no título/resumo. Dentre os termos relacionados ao tema, apenas no termo bioprodutos foi localizado uma patente, cujo título, resumo, depositante, número da patente, país de prioridade e ano de prioridade são apresentados a seguir:

112 a. BIOPRODUTOS

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. Technology Focus/Extension Abstract: EXAMPLE - 100, 500 ml Erlenmeyer flasks containing 60 g rice and 20 ml tap water were prepared. Each 3 platinum loop of Chaetomium brasiliense MK13089 was inoculated to them and cultured at 27degreesC for 14 days. 160 ml/flask of A new triterpene and its 50 % aqueous acetone was added and stood overnight and MEIJI SEIKA KAISHA preparation, useful as cell filtered to give 10.9 l extract. It was concentrated in vacuo to LTD (MEIJ) JP2000319287-A JP 1999 adhesion inhibitors and anti- give 4.6 l of a concentrate. It was extracted with 4.5 l ethyl MITSUBISHI CHEM inflammatory agents. acetate and the extract was concentrated in vacuo to give 2.3 CORP (MITU) g oil. It was fed to a silica gel column and stepwisely eluted by chloroform-methanol to give 376.1 mg oil. It was purified by an ODS column and a Toyopearl HW-40s column to give MK13089A substance, MK13089B substance and MK13089C substance. Brazilian molluscs specific NOVELTY - The Brazilian molluscs specific identification CRUZ F O (CRUZ- identification technique technique comprises recognition of the specific nucleic acid Individual) UNIV 2000 consists of recognition of sequences of the Biomphalaria mollusc species, by FEDERAL MINAS BR200002538-A BR specific nucleic acid polymerase chain reaction (PCR). Initiators, nucleotides and GERAIS (UYMI-Non- sequences via initiators. buffer solution, Taq poly standard) KOREA KUMHO EP1050582-A; cDNA encoding a Hevea NOVELTY - A 910 base pairs cDNA sequence (S1), fully PETROCHEMICAL EP1050582-A2; brasiliensis small rubber defined in the specification, and encoding a Hevea CO LTD (KOKU-Non- 1999 JP2000316586- particle-associated protein brasiliensis small rubber particle-associated protein (SRPP) standard) KR A; useful for producing rubber that binds to rubber particles with a diameter of less than 10 MALAYSIAN KR2000072911- from latex. micro-m, is new. RUBBER BOARD A; KR302100-B (NARP)

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. NOVELTY - A therapeutic composition (I), comprising a first agent (A1) that targets an interleukin-15 receptor (IL-15R) and a second agent (A2) that inhibits a costimulatory signal transmitted between a T cell and an antigen-presenting cell (APC), is new. USE - (I) is useful for suppressing an immune response in a patient, having an immune disease, particularly EP1284747-A; an autoimmune disease including rheumatic disease, such as WO200187330- systemic lupus erythematosus, Sjogren's syndrome, A2; Composition for treating scleroderma, mixed connective tissue disease, AU200161585-A; immune diseases, especially dermatomyositis, polymyositis, Reiter's syndrome, Behcet's US2002128436- autoimmune diseases, has disease, rheumatoid arthritis, type I or type II diabetes, BETH ISRAEL A1; EP1284747- agent targeting interleukin-15 Hashimoto's thyroiditis, Grave's disease, autoimmune DEACONESS A2; US 2000 receptor and agent that inhibits disease of the central nervous system including multiple MEDICAL CENT JP2003533488- costimulatory signal sclerosis, myasthenia gravis and encephalomyelitis, variety of (BETH-Non-standard) W; CN1441675- transmitted between T cell and phemphigus such as phemphigus vulgaris, phemphigus A; US6797263- antigen-presenting cell. vegetans, phemphigus foliaceus, Senear-Usher syndrome B2; and Brazilian phemphigus, psoriasis, inflammatory bowel US2004219148- disease, acquired immune deficiency syndrome (AIDS) or at A1 risk of developing the autoimmune disease. (I) is also useful for suppressing an immune response in a patient who has received a transplant of a biological organ, tissue or cell or vascular injury and also for eliminating a malignant or immune system cell that expresses a receptor for IL-15. (All claimed). Detecting a dimorphic fungus, useful for diagnosing fungal TF TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred WO2003027329- infections, comprises detecting Method: In detecting a dimorphic fungus, the dimorphic US DEPT HEALTH & A; the presence or absence of an fungus is Histoplasma capsulatum, Blastomyces dermatitidis, HUMAN SERVICES WO2003027329- US 2001 internal transcribed spacer-2 Coccidioides immitis, Penicillium marneffei, or (USSH) A1; EP1438429- (ITS2) nucleic acid sequence Paracoccidioides brasiliensis, or their hybrid. A1 of a dimorphic fungus within a sample.

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. Paracoccidioides infection is detected by: (1) hybridising a primer, complementary to Paracoccidioides nucleic acid Detecting infection or target, to a biological sample; (2) amplifying the target contamination by WO9629432-A; 1995 sequence; and (3) detecting it. A similar method can be used UNIV BOSTON Paracoccidioides - using WO9629432-A1; US to detect contamination; in this case nucleic acid is extracted (UYBO-Non-standard) specific primers for nucleic acid AU9653662-A before hybridisation with the primer. Also new are primers amplification. corresponding, or complementary to, a sequence specific for P. brasiliensis nucleic acid. Detection of Leishmania Leishmania protozoa derived DNA is detected by specific protozoa - comprises WO9631623-A1; gene amplification of Leishmania derived DNA (as template) SUMITOMO 1995 amplifying specific DNA JP8275799-A; with a polynucleotide contg. a sequence of 263 bp ELECTRIC IND CO JP fragments to distinguish EP819766-A1; (designated F10) or a sequence of 125 bp (designated F4), (SUME) L.braziliensis from US6022690-A both given in the specification L.mexicana. For rapid mutation screening, fragments containing portions of the human cytochrome P4501B1 gene were amplified from WO200068432- Diagnosing primary congenital genomic DNA with primers, using a polymerase chain A; EP1255855-A; glaucoma for facilitating early reaction (PCR). The PCR products were analyzed on US6127128-A; treatment of the disease and polyacrylamide minigels consisting of 5% acrylamide/bis WO200068432- 1999 better treatment planning for UNIV CONNECTICUT solution (19:1), 15 percent urea, and 1 x TBE (Tris, boric acid A2; US affected individuals, comprises (UYCO-Non-standard) and ethylene diamine tetraacetate (EDTA)). The mutations AU200048240-A; detecting nucleotide mutations were either sporadic or familial, and found in one or more EP1255855-A2; in the human cytochrome individuals or families from varying geographical populations JP2003513614- P4501B1 gene. (families of Israel, United Kingdom, Turkey, United Sates of W America, Bulgaria, Lebanon and Brazil origin). WO9830711-A1; AU9731674-A; DSM CHEMIE LINZ EP951561-A1; Enantio-selective production of GMBH (STAM) DSM Production of a (S)-cyanohydrin (I) comprises reaction of an AT9700041-A; (S)-cyanohydrin compounds - FINE CHEM aldehyde or ketone (II) with a cyanide group donor (III) in an AT406959-B; 1997 comprises reaction of carbonyl AUSTRIA GMBH organic diluent in the presence of a recombinant (S)- EP951561-B1; AT compound with cyano donor in (STAM) DSM FINE hydroxynitrile lyase (Hnl) from Hevea brasiliensis and DE59704263-G; presence of recombinant (S)- CHEM AUSTRIA NFG isolating (I) from the JP2001513625- hydroxy nitrile lyase. GMBH & CO KG W; ES2161466- (STAM) T3; US6337196- B1

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. EP632130-A; CHEMIE-LINZ GMBH EP632130-A1; Enzymatic prodn. of aliphatic (OSTS) DSM CHEMIE AT9301055-A; (S)-cyanohydrin - by reacting An enzymatic process for prodn. of aliphatic (S)- LINZ GMBH (STAM) CA2124783-A; aliphatic aldehyde or cyanohydrins comprises reacting an aliphatic aldehyde or DSM FINE 1993 JP7051076-A; asymmetrical ketone with asymmetrical aliphatic ketone with hydrocyanic acid in a CHEMICALS AT AT400035-B; hydrocyanic acid in the diluent in the presence of (S)-oxynitrilase from Hevea AUSTRIA GMBH US5714356-A; presence of (S)-oxy-nitrilase brasiliensis at a temp. of 10C. (STAM) DSM FINE EP632130-B1; from Hevea brasiliensis. CHEM AUSTRIA DE59408424-G; GMBH (STAM) JP3482239-B2 Enzymatic prodn. of aliphatic (S)-cyanohydrin(s) - by Enzymatic prodn. of aliphatic (S)-cyanohydrins by converting conversion of aliphatic an aliphatic aldehyde in a diluting agent using HCN in the 1993 CHEMIE-LINZ DEUT aldehyde(s) in a diluting agent presence of (S)-oxynitrilase from Hevea brasiliensis at DE4322064-A1 DE GMBH (OSTS) using (S) oxy-nitrilase from temps. 10C. Also claimed is the use of (S)-oxynitrilase, pref. Hevea brasiliensis at temp. up 104 to 10 deg. C. TF TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Method: (M1) further involves separating (II) from cellular host cell components by selective partitioning into a lipid Expressing somatotropin in phase that comprises oil bodies. Preferably, (II) is separated plants, for use in e.g. the by addition of oil body components and reconstitution of the aquaculture industry, oil bodies.Preferred Plant: (IV) is rape seed (Brassica spp.), MOLONEY M M comprises expressing nucleic linseed/flax (Linum usitatissimum), safflower (Carthamus 2001 (MOLO-Individual) US2002100073- acid encoding somatotropin tinctorius), sunflower (Helianthus annuus), maize (Zeamays), US HABIBI H R (HABI- A1 linked to nucleic acid encoding soybean (Glycine max), mustard (Brassica spp.) and (Sinapis Individual) oleosin protein to target the alba), crambe (Crambe abyssinica), eruca (Erucasativa), oil fusion polypeptide to the lipid palm (Elaeis guineeis), cottonseed (Gossypium spp.), phase. groundnut (Arachis hypogaea), coconut (Cocusnucifera), castor bean (Ricinus communis), coriander (Coriandrum sativum), squash, (Cucurbita maxima), Brazil nut (Bertholletia excelsa) or jojoba (Simmondsia chinensis).

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WO9703204-A; EP840792-A; DSM CHEMIE LINZ WO9703204-A2; GMBH (STAM) DSM WO9703204-A3; Hevea brasiliensis S- FINE CHEMICALS EP840792-A2; Purified, isolated (S)-hydroxynitrilase (HN), is new. Also new hydroxy:nitrilase - and AUSTRIA GMBH AT9501182-A; 1995 are: (1) DNA encoding (S)-HN; (2) vector contg. the DNA; (3) recombinant equivalent of high (STAM) CHEMIE- AT404837-B; AT host cell having the DNA introduced by the vector; and (4) specific activity, for chiral LINZ GMBH (OSTS) JP11508775-W; recombinant protein produced by the cell. synthesis of cyano:hydrin(s). DSM FINE CHEM US6046042-A; AUSTRIA NFG GMBH EP840792-B1; & CO KG (STAM) DE59608804-G; TW469293-A; ES2170251-T3

Improving stability of protein or peptide in yeast - by The method is esp. used where (I) is the 2S storage protein expressing with a peroxisomal (BZN) of Brazil nuts or the synthetic proteins E and ELE (or WO9424289-A1; 1993 targetting sequence, allowing EUROLYSINE their polymers). Yeast expressing these (I) are useful as food FR2704237-A1; FR accumulation of unstable or (EURO-Non-standard) additives (having a high content of essential amino acids, AU9466810-A toxic products, and new yeast partic. Met or Cys). strains useful as food additives. EP704457-A; EP704457-A1; Isolated allergenic proteins of (A) Allergenic proteins from the latex or tissue of Hevea JP8277295-A; natural rubber latex - used to brasiliensis (HB) in purified form, and allergenic subunits or JP3431371-B2; 1995 RUBBER RES INST develop prods. for detecting aggregates are claimed. Also claimed are: (B) a monoclonal JP2003267999- MY MALASIA (NARP) allergies and as de-sensitising antibody (MAb) against an allergenic protein as in (A); (C) a A; agents for treating allergies. method for e JP2003268000- A; US6759517- B1 Macrolide 0466HK-1 useful as 1999 antifungal agent obtained by HIGETA SHOYU KK NOVELTY - A new antifungal macrolide 0466HK-1. JP2001072698-A JP culturing Nocardia brasiliensis (HGET) strain.

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. NOVELTY - The inoculum of Agaricus blazci Murrill is Method of culturing Brazilian inoculated on liquid culture medium, sterile air is introduced 1999 bushroom mycelium and and cultured for 2-4 weeks to obtain mycelium of Agaricus LI H (LIHH-Individual) CN1269423-A CN extracting protein blazci Murrill and culture liquor, and the mycelium is polysaccharide. undergone the processes o Microbial mixture for fixing nitrogen and increasing solubility of phosphorus FR2806420-A1; compounds to improve fertility NOVELTY - Preparing a mixture (I) of micro-organisms by 2000 POLLAK A (POLL- SK200000386- of soil, comprises the co- co-fermentation of the micro-organisms in nutrient soil, which SK Individual) A3; NL1017592- fermentation of Azotobacter is nitrogen free but contains phosphorus, is new. C2 croococcum, Azospirillum brasiliense and Bacillus megaterium. EP969095-A; EP969095-A2; DSM FINE CHEM Mutant (S)-Hydroxynitrile lyase CA2277594-A1; NOVELTY - (S)-Hydroxynitrile lyase (HNL) enzyme AUSTRIA GMBH enzyme with enhanced JP2000125886- 1998 comprising a Hevea brasiliensis or Manihot esculenta HNL in (STAM) DSM FINE substrate acceptance useful for A; AT9801159-A; AT which one or more bulky amino acids are replaced by less CHEM AUSTRIA NFG converting aldehydes or AT407397-B; bulky amino acids is new. GMBH & CO KG ketones to (S)-cyanohydrins. US6319697-B1; (STAM) EP969095-B1; DE59910627-G

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. They are used in pharmaceutical and agrochemical WO9909974-A; compositions for the treatment and prevention of fungal EP1007031-A; infections in animals and the control of phytopathogenic fungi WO9909974-A1; in plants (claimed). In animals, including humans, they may AU9889123-A; be used to treat fungal infections caused by Candida (C. US5972996-A; albicans, C. glabrata, C. tropicalis, C. pseudotropicalis), EP1007031-A1; Cryptococcus neoformans, Pneumocystis carinii, Aspergillus New 4-cyano-4- CZ200000632- spp. (A. flavus, A. fumigatus), Coccidioides (C. immitis), deformylsordarin derivatives - A3; Paracoccidioides (P. brasiliensis), Histoplasma (H. 1997 used for treating fungal MERCK & CO INC HU200002708- capsulatum) or Blastomyces (B. dermatitidis) as well as GB infections e.g. candidiasis, and (MERI) A2; Trichophyton (T. mentographytes, T. rubrum), Microsporum for controlling phytopathogenic SK200000209- (M. canis) or Epidermophtyon (E. floccosum), mucosal fungi in plants. A3; infections caused by C. albicans, species of filamentous fungi JP2001513553- such as Geotrichum (G. clavatum), Trichosporon (T. beigelii), W; AU740477-B; Blastoschizomyces (B. capitatus), Sporothrix (S. schenck ii), NZ502763-A; Scedosporuim (S. apiosperum), Cladosporum (C. carrioniii) EP1007031-B1; and Pityrosporum ovale, and infections caused by parasites DE69815355-E; such as Toxoplasma, Cryptosporidium, Leishmania, ES2198064-T3 Tripanosoma, Giardia and Trichomonas. New anthracycline antibiotic Antibiotic SO-75R1 of formula (I) is new. MIYARISAN SO-75R1 - is used as an (I) is produced by incubating a strain of Nocardia (e.g., 1992 SEIBUTSU IGAKU antiviral agent of against gram- Nocardia brasiliensis IFM 0075, FERM P-13071) on a JP6041180-A JP KENKYUSHO KK positive bacteria, e.g., nutrition medium (pH 7) containing carbon source, nitrogen (MIYA-Non-standard) Nocardia. source and minerals at 25-40 deg.C for a period of 1-6 days. TF TECHNOLOGY FOCUS - BIOLOGY - Preferred Microorganism: DSM 14527 is an endophyte of the Brazilian plant Mayfenus aquiforlia. Preparation: DSM 14527, or its mutants or variants, are grown under submerged aerobic New dichloropyrrole type conditions on a conventional growth medium, at 22-30 KNOELL-INST antibiotic, useful for treating 2001 degreesC and pH 5-9.5, preferably 6.5-7.5, for 48-144 hours. NATURSTOFF- bacterial infections in animals DE10151215-A1 DE The biomass and broth are separated; both extracted with an FORSCH EV HANS and plants, produced by organic solvent; the extracts concentrated and the residue (KNOE-Non-standard) Streptomyces DSM 14527. purified, e.g. by column chromatography on silica; gel chromatography on dextran and then HPLC on a reverse- phase silica column, to isolate (I).

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. WO200071585- A; EP1173485-A; New human monoclonal WO200071585- antibody against TF TECHNOLOGY FOCUS - BIOLOGY - Preferred A1; Staphylococcus aureus, useful Antibody: (I) is immunoglobulin (Ig) G1-G4, IgM, IgA1, IgA2, 1999 MEDAREX INC AU200058671-A; for treating and preventing IgAsec, IgD or IgE, most preferably IgG1k. (I) can bind to at US (MEDA-Non-standard) EP1173485-A1; infections, including those least one methicillin-resistant S. aureus strain, especially to JP2003503015- caused by methicillin-resistant strains Iberian, Emrsa, Ontario or Brazilian. W; strains. AU2004201429- A1 EP808843-A; EP808843-A2; Macrolides of formula (I), referred to as compound 0406, are New macrolide antibiotic JP9295980-A; 1996 new. R1 Also claimed is a Nocardia brasiliensis strain HIGETA SHOYU KK compound 0406 - having US6004995-A; JP capable of producing (I). (HGET) immunosuppressant activity. US6090610-A;

EP808843-B1; DE69720101-E Nocardia brasiliensis IFM 0667 strain (FERM BP-6727) was New monoterpene compounds inoculated in 2% glucose-added Brain Heart Infusion liquid 1999 HIGETA SHOYU KK BMT having antitumor and medium (25 ml), and cultured with shaking at 30degreesC for JP2001002613-A JP (HGET) antibacterial activities. 72 hours. The culture (2 ml) was further cultured in the same medium (200 ml). New nucleic acid encoding an isopentenyl diphosphate NOVELTY - A nucleic acid (A) encoding an isopentyl KOREA KUMHO 1999 isomerase from Hevea diphosphate (IPP) isomerase from Hevea brasiliensis having PETROCHEMICAL EP1046709-A; EP brasiliensis comprising 234 a sequence (I) of 234 amino acids, given in the specification, CO LTD (KOKU-Non- EP1046709-A1 amino acids, useful in rubber is new. standard) biosynthesis. New oligo:nucleotide An oligonucleotide (ON) hybridisation assay probe (I), is hybridisation assay probes - new, which is able to detect the presence of Blastomyces 1994 used for the detection or GEN-PROBE INC dermatitidis (BD) and Paracoccidioides brasiliensis (PB), US5558990-A US quantification of Blastomyces (GENP-Non-standard) where the probe has a length of 15-100 nucleotides and can dermatitidis or form a stable hybrid u Paracoccidioides brasiliensis.

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. New tetra:cyclic anthraquinone Tetracyclic anthraquinone derivatives of formula (I), derivative 0089 compounds - designated '0089' compounds, and their salts are new. R = 1996 having antibacterial and HIGETA SHOYU KK ristosamine, -OH or -OCH3, in compound '0089-A', '0089-B' JP9309861-A JP especially antitumour activity, (HGET) or '0089-C' respectively. Also claimed are new Nocardia prepared by culturing new brasiliensis strains having t Nocardia brasiliensis strain. TF TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Vector: The vector comprises a sequence that permits passage of the vector from a first prokaryotic cell to a second prokaryotic cell by direct transfer. The direct transfer is by conjugation. The E. coli origin of replication is Co1E1 and the New vector comprising a Actinomycetes origin of replication is pJV1. The first WO2003083087- nucleic acid, an E. coli and prokaryotic cell is E. coli. The second prokaryotic cell is A; Actinomycetes origin of Actinomycetes. The second prokaryotic cells is Acetobacter WO2003083087- replication, a cos cosmid xylinum, Achrombacter parvulus, Acinetobacter spp., 2002 A1; cloning site, and an origin of Aeromonas spp., Agrobacterium spp., Alcaligenes spp., WYETH (AMHP) US US2003224484- transfer, useful for expressing Anabaena spp., Azospirrillum brazilense, Azotobacter spp., A1; polypeptides and for Bordetella spp., Caulobacter spp., Enterobacteriaceae, AU2003224802- manipulating Actinomycetes Haemophilus influenza, Hypomicrobium X, Legionella A1 biosynthesis genes. pneumophila, Methylophilus methyltrophus, Ethylosinus trichosporium, Myxococcus xanthus, Neisseria spp., Paracoccus denitrificans, Pseudomonas spp., Rhizobium spp., Rhodopseudomonas spp., Rhodospirillum spp., Thiobacillus spp., Vibrio cholerae, Xanthomonas spp., Yersinia enterocolitica, Myxococcusor Bacteroides. TF TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Fusion Protein: (I) is encoded by a nucleic acid comprising WO2003054142- Novel fusion protein (S2). In (II), the ATP generating polypeptide is chosen from A3; comprising an adenosine ATP sulfurylase, hydrolase and ATP synthase. The ATP SRINIVASAN M US2003113747- triphosphate generating sulfurylase is a thermostable sulfurylase encoded by (S1). (SRIN-Individual) A1; 2002 thermostable sulfurylase The nucleotide sequence encodes (S4). The thermostable REIFLER M (REIF- WO2003054142- US polypeptide bound to luciferase sulfurylase is active at room temperature. The ATP Individual) 454 CORP A2; polypeptide and at least one sulfurylase is from a thermophile. The thermophile is a (FOUR-Non-standard) AU2002365146- affinity tag, useful for thermophilic bacteria is chosen from Bacillus A1; EP1451293- sequencing nucleic acid. stearothermophilus, Thermus thermophilus, B. caldolyticus, A2 B. subtilis, B. thermoleovorans, etc. The ATP generating polypeptide and ATP converting polypeptide are from a

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. eukaryote or a prokaryote. The eukaryote is chosen from animal (e.g., mammal, rodent, insect, worm, mollusk, reptile, bird and amphibian), plant (e.g., Arabidopsis thaliana, Brassica napus, Allium sativum, Amaranthus caudatus, Hevea brasiliensis, etc), fungus (e.g., Penicillium chrysogenum, Stachybotrys chartarum, Aspergillus fumigatus, Podospora anserina, Trichoderma reesei and Riftia pachyptila) and yeast (e.g., Saccharomyces cerevisiae, Candida tropicalis, C. lypolitica, C. utilis, Kluyveromyces lactis, Schizosaccharomyces pombe, Yarrowia lipolytica, Candida spp., Pichia spp. and Hansenula spp.). HOFFMANN LA ROCHE & CO AG F (HOFF) UNIV INSTELLING ANTWERPEN UIA WO200198491- The three disease-associated polymorphisms were detected Novel genetic polymorphisms (UYIN-Non-standard) A; EP1366156-A; by PCR-amplification of the appropriate genomic DNA- in the Van Buchem- UNIV ANTWERPEN WO200198491- fragment from Van Buchem's and sclerosteosis patients, sclerosteosis disease region INSTELLING (UYAN- A2; followed by sequencing of the fragments and comparison to 2000 that are associated with Non-standard) AU200172482-A; DNA of healthy individuals. To make high throughput EP abnormal bone formation BALEMANS W EP1366156-A2; screening possible a PCR-based assay was developed for useful for diagnosis and (BALE-Individual) JP2004520005- two mutations. For the mutation in the Brazilian patients, a assessment of osteoporosis or EBELING M (EBEL- W; modified primer was designed creating a MboI restriction site sclerosteosis in humans. Individual) US2004132021- in the mutated allele. FOERNZLER D A1 (FOER-Individual) PATEL N (PATE- Individual) VAN HUL W (

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RENESSEN LLC (RENE-Non-standard) TF TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred MONSANTO CO DNA: In (I), the expression of monomeric AS elevates the Novel isolated DNA encoding (MONS) WEAVER L level of L-tryptophan in the plant relative to an untransformed monomeric anthranilate M (WEAV-Individual) WO200290497- plant having the same genetic background. The monomeric synthase useful for conferring LIANG J (LIAN- A2; AS is from Agrobacterium tumefaciens, Rhizobium meliloti 2001 tolerance to a tryptophan Individual) CHEN R US2003097677- (Genbank Accession No. GI 95177), Mesorhizobium loti US analog to a plant and/or (CHEN-Individual) A1; (Genbank Accession No. GI 13472468), Brucella melitensis altering tryptophan content in a JEONG S S (JEON- AU2002257246- (Genbank Accession No. GI 17982357), Nostoc sp. plant, or for making an animal Individual) MITSKY T A1 (Genbank Accession No. GI 17227910, GI 17230725), feed or a human food. (MITS-Individual) Azospirillum brasilense (Genbank Accession No. GI SLATER S (SLAT- 1174156) or Anabaena (Genbank Accession No. GI 152445). Individual) RAPP W (RAPP-Individual)

WO2003010294- A; Novel isolated nucleic acid TF TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred WO2003010294- molecule encoding isopentenyl DU PONT DE Host Cell: (IX) is chosen from bacteria, yeast, filamentous A2; diphosphate, IPP, pathway NEMOURS & CO E I fungi, algae and green plants. Preferably, the host cell is US2003119098- 2001 enzyme, useful for obtaining (DUPO) HALLAHAN Aspergillus, Trichoderma, Saccharomyces, Pichia, Candida, A1; EP1434784- US nucleic acid molecule encoding D L (HALL-Individual) etc, or is a rubber tree (Hevea brasiliensis), tobacco A2; IPP pathway enzyme, and for KEIPER-HRYNKO N (Nicotiana spp.), tomato (Lycopersicon spp.), potato AU2002355297- regulating IPP biosynthesis in M (KEIP-Individual) (Solanum spp.), hemp (Cannabis spp.), etc. A1; organism. MX2004000645- A1 USE - (I) is useful for manufacturing rubber in vitro and in vivo (claimed). ADVANTAGE - (I) enables manufacture of rubber. Novel nucleic acid molecule of DETAILED DESCRIPTION - INDEPENDENT CLAIMS are KOREA KUMHO 1999 Hevea isopentyl diphosphate included for the following: PETROCHEMICAL JP2003144183-A US isomerase, useful for (1) a vector (II) containing (I); CO LTD (KOKU-Non- manufacturing rubber. (2) a transformed host (III) containing (II); standard) (3) manufacturing (M1) rubber in vitro involving isolating (I), producing (III) in which (I) is transduced, and cultivating (III) in a culture medium in which isopentyl diphosphate isomerase

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. of Hevea brasiliensis (IPIHb) is produced, and synthesizing rubber in vitro, using IPIHb;

The analytical sensitivity of this system using (S1) and (S3) SDA primer pair was shown to be approximately 50 genome equivalents of Mycobacterium tuberculosis DNA. Twenty-four isolates of M. tuberculosis from North and South America, Asia, Africa, and Europe were tested in SDA using (S1) and (S3), (S4) and (S5). All yielded specific products by primer SPEARS P A (SPEA- extension analysis with (S8), as did four North American Novel oligonucleotide primers Individual) HELLYER isolates of M. bovis, M. canum, M. microti. The (S1), (S3), useful for detecting T J (HELL-Individual) (S4) and (S5) primer set was also tested for cross reactivity 1997 Mycobacterium tuberculosis DESJARDIN L E with other species of Mycobacterium. No significant cross- US6156508-A US complex alpha-antigen in (DESJ-Individual) reaction was observed among 36 strains of non-tuberculous clinical specimens or in vitro CAVE M D (CAVE- mycobacterium comprising 10 isolates of M. avium-M. cultures. Individual) EISENACH intracellulare, seven of M. fortuitum five of M. xenopi, four of K D (EISE-Individual) M. malmoense, three of M. chelonei and one each of M. scrofulaceum, M. gordonae, M. abscessus and M. celatum. Similarly, no cross reaction was detected with the phylogenetically related organisms Actinomyces israeli, Corynebacterium diphtheriae, Nocardia braziliensis, Rhodococcus rhodocrous and Streptomyces albus. USE - The IPI can be used in the preparation of rubber. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for the following: (1) a nucleic acid molecule (II) encoding the nucleic acid JP2000300276- Nucleic acid molecule sequence (S2) of 1288 nucleotides (nts) fully defined in the KOREA KUMHO A; encoding a novel isopentenyl 1999 specification; PETROCHEMICAL KR2000067734- diphosphate isomerase is US (2) a nucleic acid molecule (III) separated by hybridization CO LTD (KOKU-Non- A; US6316695- useful in catalyzing rubber to (I) under a severe washing condition using 0.45 M NaCl, standard) B1; JP3416081- preparation. 0.04 M sodium citrate and 0.1 5 sodium dodecyl sulfate at 45 B2; KR379832-B degreesC; (3) a vector (IV) containing the above nucleic acid molecule;

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. (4) a transformed host which can express a nucleic acid molecule and contains (IV); (5) preparing in vitro rubber consisting of providing the above nucleic acid molecule, producing a transformed host cell by transferring the nucleic acid molecule to the host cell and culturing said transformed host in a proper medium to produce IPI Hevea Brasiliensis (IPIHb), and promoting rubber synthesis by using said IPIHb. DSM FINE CHEM AUSTRIA NFG GMBH & CO KG (STAM) DSM FINE CHEM Preparation of enantiomer- TECHNOLOGY FOCUS - BIOLOGY - Preferred CA2415168-A1; AUSTRIA GMBH enriched cyanohydrins for use Components: The HNL is a native (S)-HNL from manioc or AT411064-B; (STAM) SKRANC W in synthesis of, e.g. alpha- Hevea brasiliensis; recombinant (S)-HNL from genetically AT200102032-A; (SKRA-Individual) 2001 hydroxy acids for producing modified microorganisms consisting of Pichia pastoris, JP2003235594- POECHLAUER P AT biologically active substances, Escherichia coli, or Saccharomyces cerevisiae; native (R)- A; EP1323828- (POEC-Individual) by reacting acetal or ketal in HNL from Prunus amygdalus, Prunus laurocerasus, or A2; WIRTH I (WIRT- the presence of cyanide group Prunus serotina; or recombinant (R)-HNL. It may be present US2003129713- Individual) donor with hydroxynitrile lyase. as immobilized. A1 NEUHOFER R (NEUH-Individual) MAYRHOFER H (MAYR-Individual)

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. DSM FINE CHEM AUSTRIA NFG GMBH & CO KG (STAM) POECHLAUER P (POEC-Individual) TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Preparation of enantiomer- SKRANC W (SKRA- Components: The HNL is a native (S)-HNL from manioc or CA2415185-A1; enriched heterocyclic (R)- and Individual) Hevea brasiliensis, recombinant (S)-HNL from genetically AT200102033-A; (S)-cyanohydrin compounds by MAYRHOFER H 2001 modified microorganisms consisting of Pichia pastoris, US2003129712- reacting ketone compounds (MAYR-Individual) AT Escherichia coli, or Saccharomyces cerevisiae, native (R)- A1; EP1323830- with (R)- or (S)-hydroxynitrile WIRTH I (WIRT- HNL from Prunus amygdalus, Prunus laurocerasus, or A2; AT411065-B; lyase in presence of cyanide Individual) Prunus serotina, or recombinant (R)-HNL. The HNL is JP2003250593-A group donor. NEUHOFER R optionally immobilized. (NEUH-Individual) GRIENGL H (GRIE- Individual) FECHTER M (FECH-Individual) DSM FINE C

EP927766-A; TF TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - DSM FINE CHEM EP927766-A1; Preferred materials: An aliphatic, aromatic or heteroaromatic AUSTRIA GMBH JP11243983-A; 1997 Preparation of enantiomers of aldehyde or an asymmetric ketone is used in the reaction. (STAM) DSM CA2257562-A1; AT optically active cyanohydrins. The cyanide group donor is hydrocyanic acid. The native S- CHEMIE LINZ GMBH AT9702192-A; hydroxynitril lyase is derived from Manihot esculenta or (STAM) AT406961-B; Hevea brasiliensis. US6225095-B1 WO200114571- Producing chymosin in seeds USE - The method is useful for producing plant seeds, in A; EP1216306-A; of plants such as rice, flax, particular seeds of soybean, rape seed, sunflower, cotton, WO200114571- rape seed, by transforming corn, tobacco, alfalfa, wheat, barley, oats, sorghum, SEMBIOSYS 1999 A1; plant cell with a nucleic acid Arabidopsis thaliana, potato, flax/linseed, safflower, oil palm, GENETICS INC US AU200066780-A; encoding chymosin operably groundnut, Brazil nut, coconut, castor, coriander, squash, (SEMB-Non-standard) EP1216306-A1; linked to transcription regulator jojoba and rice containing 0.5%, 1%, 2% or 4% (w/w) MX2002001904- and terminator sequences. chymosin in the total seed protein (claimed). A1

126

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. DSM FINE CHEM AUSTRIA NFG GMBH & CO KG (STAM) SKRANC W (SKRA- TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Production of protected Individual) Enzyme: The enzyme is a native (S)-hydroxynitrile lyase EP1323829-A; enantiomer-enriched POECHLAUER P derived from manioc or Hevea brasiliensis, a recombinant AT200102044-A; cyanohydrins useful as (POEC-Individual) (S)-hydroxynitrile lyase derived from genetically modified EP1323829-A2; 2001 intermediates comprises WIRTH I (WIRT- Pichia pastoris. Escherichia coli or Saccharomyces CA2415190-A1; AT reacting an aldehyde or ketone Individual) cerevisiae, a native (R)-hydroxynitrile lyase derived from US2003129714- with a cyanoformate ester in NEUHOFER R Prunus amygdalis, Prunus laurocerasus or Prunus serotina, A1; AT410792-B; the presence of an (R)- or (S)- (NEUH-Individual) or a recombinant (R)-hydroxynitrile lyase. JP2003210187-A hydroxynitrile lyase. MAYRHOFER H

(MAYR-Individual) DSM FINE CHEM AUSTRIA GMBH (STAM) WO200148178- EFFENBERGER F A; EP1246909-A; Production of recombinant (EFFE-Individual) JFC The (A)-encoding gene is present on a plasmid, e.g. WO200148178- hydroxynitrile lyase, useful for JUELICH FINE pQE4.Preferred Enzymes: (A) is a naturally occurring A1; DE19963485- 1999 producing cyanohydrins, CHEMICALS GMBH enzyme or its mutant, especially from Sorghum bicolor, A1; DE intermediates for e.g. (JFCJ-Non-standard) Manihot esculenta, Hevea brasiliensis, Linum usitatissimum AU200131645-A; pharmaceuticals, using low WAJANT H (WAJA- or Prunus spp. Especially it is a (S)-hydroxynitrile lyase. EP1246909-A1; concentration of inducer. Individual) FORSTER US2003148440- S (FORS-Individual) A1

127

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. WO9963104-A; EP1082449-A; DE19824491-A1; WO9963104-A1; TF TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - AU9942647-A; Stereoselective preparation of Preferred Process: Preparation of trans-(I) is carried out by BAYER AG (FARB) EP1082449-A1; cyclohexylcyanohydrin 1998 reacting (II) in the presence of (R)-oxynitrilase obtained from BAYER MX2000011921- derivatives, useful as DE bitter almonds (Prunus amygdalus). It is also possible to use CROPSCIENCE AG A1; intermediates for herbicides (S)-oxynitrilase obtained from manioc (Manihot esculenta) or (FARB) JP2002517203- and pesticides. the rubber tree (Hevea brasiliensis). W; US6465222- B1; EP1082449- B1; DE59904461- G; ES2189512- T3 EP1305429-A; WO200212462- A; WO200212462- Variant endoglucanase-III, Genomic DNA was obtained from Acremonium GENENCOR INT INC A2; useful in treatment of cellulose brachypenium, Chaetomium brasillience, C. vitellium, (GEMV) GUALFETTI AU200179095-A; containing textile and wood Emericella desertoru, Fusarium equiseti, Gliocladium roseum, P (GUAL-Individual) 2000 EP1305429-A2; pulp, in treatment of biomass Humicola grisea, Myceliopthora thermophila, Penicillium MITCHINSON C US US6623949-B1; to glucose and as a feed notatum and Phanerochaete chrysosporium and isolated. (MITC-Individual) US2003186418- additive, is a variant of EGIII Polymerase chain reaction (PCR) was performed on a PHILLIPS J (PHIL- A1; from Trichoderma reesei. standard PCR machine. Individual) US2003203467- A1; JP2004519212- W

128

2. TEMA: BIORREMEDIAÇÃO

Apresenta-se a seguir o título da patente que cita Brasil no título/resumo, sobre o tema biorremediação, com seu respectivo título, resumo, depositante, número da patente, país de prioridade e ano de prioridade.

129

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. TECHNOLOGY FOCUS - BIOLOGY - Preferred Bacteria: The butane-utilizing-bacteria in the degradation of PCB pollutant belonging to the genus of Pseudomonas, Variovorax, Nocardia, Degradation of Chryseobacterium, Comamonas, Aeromonas, polychlorinated biphenyls Sternotrophomonas, Sphingobacterium, Shewanella, pollutant in air, soil and Phyllobacterium, Clavibacter, Alcaligenes, Gordona, ground waste water, Carynebacterium and/or Cytophaga. The butane- ANTHONY F (ANTH- involves treating pollutants utilizing-bacteria belongs to the species putida, US6156203-A US 1996 Individual) with butane-utilizing rubrisubalbicans, aeruginosa, paradoxus, aestriodes, bacteria in presence butane brasilinesis, restricta, globerula, indologenes, from butane substrate meningosepticum, acidovorans, delafieldii, under aerobic conditions. rhodochrous, erythropolis, fascians, barkeri, esteroaromaticum, saperdae, varians, kristinae, caviae, maltophilia, thalpophilum, spiritivorum, putrefaciens B, myrsinacearum, michiganense, xylosoxydans, terrae, aquaticum B and/or johnsonae.

130

3. TEMA: INTEGRAÇÃO: ALIMENTAÇÃO, NUTRIÇÃO E SAÚDE

Apresentam-se a seguir o título das patentes que citam Brasil no título/resumo, sobre o tema Integração: Alimentação, Nutrição e Saúde, com seus respectivos títulos, resumos, depositantes, números da patente, país de prioridade e ano de prioridade.

131

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. Technology Focus/Extension Abstract: TECHNOLOGY FOCUS - BIOLOGY - Preferred Ingredients: The functional component enriched components are cereal seed, buckwheat seed, grass seed, millet seed, amaranthus Germinated seed powder as seed or sorghum seed; soybean seed, adzuki bean, mung health/nutritional food, is obtained by bean, kidney bean, green peas, broad beans, lima bean, Lens drying and grinding seed powders e.g. esculenta, sword bean, Mucuna pruriens, Cyamopsis PBM KK (PBMP- JP2003334012- rice and wheat without modifying tetragonolobus, windged beans or scarlet runner bean; JP 2002 Non-standard) A functional components e.g. ferulic chestnut, ginkgo nut, walnut, opium poppy seed, horse chestnut acid, phytic acid, inositol phosphate fruit, Japanese oak fruit, chinquapin fruit, water caltrop fruit, pine and polyphenol. nuts, pistachio nut, Brazil nut or cashew nut; green pepper, paprika, nutmeg, pepper, anise, cardamom, caraway, cumin, dill, coriander, vanilla bean, mustard, cayenne pepper, sesame, garlic, hemp or mustard seed; and Coffea arabica, cacao, coconut, Kochia scoparia or maize seed. Technology Focus/Extension Abstract: TECHNOLOGY FOCUS - FOOD - Preferred Food: The dried plant parts are freeze-dried plant parts in powder form. Suitable plant parts are fruits, including berries and/or wild fruits; spices and herbs, preferably fennel, elder-blossom, peppermint, St. Production of natural food with honey John's wort, rosemary, vanilla, cinnamon, cloves, aniseed, WO200042866- and plant constituents, e.g. coating, ginger, thyme, camomile, coriander, curry, caraway, sesame, A1; starting material for natural remedy, pistachio, Brazil nuts, peanuts, walnuts or hazel nuts, vegetable AU200032711- KAISER K (KAIS- additive or instant drink powder or fats or oils, micro-organisms and/or synthetic aromas. The A; DE 1999 Individual) granulate, involves mixing warm vitamin used is vitamin C. The honey is heated to 35-50, DE10003362- honey with powder mixture of plant preferably 39degreesC. The product contains not less than 70 A1; parts and vitamins. parts weight honey and its flavor depends on the plant DE10080086-T constituents. It may also contain other products from bees, preferably bee-bread, pollen, royal jelly and/or propolis extract. Flavor enhancers, nutrients and/or an acidulating agent may also be added. The honey may be (partly) replaced by artificial honey.

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Em relação aos termos referentes ao tema Integração: Alimentação, Nutrição e Saúde, em um termo (Produção de Vacinas) foram localizadas patentes que estão relacionadas ao Brasil em seu título/resumo. Os títulos das patentes, resumo, depositante, número da patente, país de prioridade e ano de prioridade são apresentados a seguir:

133 a. TERMO: PRODUÇÃO DE VACINAS

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. NOVELTY - An isolated monoclonal antibody mAb PAB-1 (ATCC PTA-4005), which binds to a surface antigen on nematode third stage larvae (L3), is new. New monoclonal antibody USE - The monoclonal antibody is useful for detecting nematode mAb PAB-1 that binds to a infection in sheep. The surface antigens are useful for eliciting an antibody response in WO2003064475- surface antigen on the gut mucus of sheep of other susceptible animals, or in AGRESEARCH A; nematode third stage manufacturing a composition for preventing, treating or reducing the susceptibility to LTD (AGRE- WO2003064475- larvae, useful for nematode infection or infestation in animals, in particular sheep from nematodes, such Non-standard); A1; AU 2002 diagnosing, preventing, as Trichostrongylus colubriformis, Cooperia curticei, Nematodirus spathiger, OVITA LTD AU2003206466- treating or reducing the Haemonchus contortus, (OVIT-Non- A1; EP1468022- susceptibility to nematode Ostertagia circumcincta, T. axei, T. vitrinus, O. ostertagi, C. oncophera, N. brasiliensis, standard) A1 infection in animals, in or D. eckerti (claimed). particular sheep. The monoclonal antibody is also useful in identifying and isolating the surface antigen for development into a vaccine or other immunotherapy against nematode infections. TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Vaccine: The antigen is derived from Epidermophyton floccusum, Microsporum audouini, M. canis, M. distortum, M. equinum, M. gymsum, M. nanum, Trichophyton centricum, T. equinum, T. gallinae, T. gypseum, T. megnin, T. mentragrophytes, T. quinckeanum, T. rubrum, T. schoenleini, T tonsurans, T. verrucosum, T. verrucosum var. album, var. discoides, var. ochraceum, T. violaceum, and/or T. faviforme, Aspergillus fumigatus, A. flavus, A. niger, A. nidulans, A. terreus, A. sydowi, A. flavatus, A. glaucus, Blastoschizomyces capitatus, Candida albicans, C. enolase, C. tropicalis, New multivalent vaccine JIRA V (JIRA- WO2003018051- C. glabrata, C. krusei, C. parapsilopsis, C. stelatoidea, C. kusei, comprising one or more Individual); A; C. parakwsei, C. lusitaniae, C. pseudotropicalis, C. guilliermondi, C. carrionii, heat-inactivated fungal JIRATHITIKAL US2003039667- Coccidioides immitis, Blastomyces dermatidis, Cryptococcus neoformans, pathogens, useful for V (JIRA- A1; Geotrichum clavatum, Histoplasma capsulatum, Klebsiella pneumoniae, US 2001 treating and preventing Individual); WO2003018051- Paracoccidioides brasiliensis, Pneumocystis carinii, Pythium insidiosum, fungal infections, and for JIRATHITKAL A1; Pityrosporum ovale, Saccharomyces cerevisiae, S. boulardii, S. pombe, Scedosporium inducing immunity to fungal V (JIRA- AU2002326766- apiosperum, Sporothrix schenckii, Trichosporon beigelii, pathogens. Individual) A1 Toxoplasma gondii, Penicillum marneffei, Malassezia spp., Fonsecaea spp., Wangiella spp., Sporothrix spp., Basidiobolus spp., Conidiobolus spp., Rhizopus spp., Mucos spp., Absidia spp., Mortierella spp., cunninghamella spp. or Saksenaea spp.. The inactivated pathogen of the oral vaccine is a fungus or its part. Preferred Immunogen: The immunogen is administered to the host without an immune adjuvant. The immune response is directed against fungal infection. The amount of immunogen comprised in the pill is 0.0000001-20 % by weight.

134

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR.

Stimulating immune responses in a patient for TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Method: The non-specific preventing or treating immune response enhancer is an adjuvant, preferably L. braziliensis antigen (LbeIF4A) CORIXA CORP Leishmaniasis, by or a cytokine. The vaccine preferably comprises a polypeptide having an immunogenic (CORI-Non- US6365165-B1 US 1995 administering a vaccine portion of a Leishmania antigen comprising a 199 or 546 residue amino acid sequence, standard) comprising a polypeptide given in the specification. The vaccine further comprises a delivery vehicle which comprising an immunogenic comprises a biodegradable microsphere. portion or epitope of Leishmania antigen.

Identifying targeting UNIV TEXAS WO200220722- peptides useful for treating TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Methods: In identifying SYSTEM A2; e.g. diabetes mellitus, targeting peptides, the phage are recovered by infecting pilus positive bacteria, or by (TEXA); ARAP AU200190652-A; inflammatory diseases, amplifying phage inserts, ligating the amplified inserts to phage DNA, and producing W (ARAP- EP1315965-A2; cancer, or autoimmune US 2000 phage from the ligated DNA. The sample is a thin section of an organ or tissue. The Individual); US2004048243- diseases, comprises bound phage is recovered by Positioning and Ablation with Laser Microbeams (PALMS), PASQUALINI R A1; exposing a sample to a or by Biopanning and Rapid Analysis of Selective Interactive Ligands (BRASIL). (PASQ- JP2004515751- phage display library and Individual) W recovering phage bound to the sample.

NOVELTY - Nucleic acids (NA's) from yeast and fungi encoding proteins involved in a pathway leading to programmed cell death, are new.

USE - The nucleic acids, polypeptides, antibodies and compounds which bind to and WO200102550- modulate the expression or functionality of the polypeptides are useful for preparing A; EP1196635-A; Yeast and fungal nucleic medicaments for treating diseases associated with yeast and fungi infections, such as WO200102550- acids encoding proteins diseases caused by Candida spp. (especially C. albicans when using antibodies as a A2; involved in a pathway medicament), Aspergillus spp., Microsporum spp., Trichophyton spp., Fusarium spp., AU200057984-A; leading to programmed cell JANSSEN Zygomycetes spp., Botritis spp., Cladosporium spp., Malassezia spp., Epidermophyton NO200200011-A; death, useful for treating PHARM NV EP 1999 floccosum, Blastomyces dermatitidis, Coccidioides immitis, Histoplasma capsulatum, EP1196635-A2; proliferative disorders, (JANC) Paracoccidioides brasiliensis, Cryptococcus neoformans or Sporothrix schenckii.The JP2003504013- yeast and fungal infections, genetically modified yeast or fungus is useful in the preparation of a medicament for W; or for preventing apoptosis modifying endogenic flora of humans and other mammals.They are also useful for KR2003000012- in certain diseases. treating proliferative disorders or for preventing apoptosis in certain diseases (all A; NZ515568-A; claimed). The medicaments are useful for treating humans and plants having the yeast ZA200110481-A or fungal infections.The nucleic acids and polypeptides represent potential targets for the identification of new compounds which can be used in alleviating diseases or conditions associated with yeast or fungal infections.

135

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred antigen: The antigen is a bacterial, fungal, protozoal, viral, helmenthic or other microbial pathogenic antigen, preferably Streptococcus pyogenes, S. pneumoniae, Neisseria gonorrhoea, N. meningitidis, Corynebacterium diptheriae, Clostridium botulinum, C. perfringens, C. tetani, Haemophilus influenzae, Klebsiella pneumoniae, K. ozaenae, K. rhinoscleromotis, Staphylococcus aureus, Vibrio choleae, E. coli, Pseudomonas aeruginosa, Campylobacter (Vibrio) fetus, C. jejuni, Aeromonas hydrophila, Bacillus cereus, Edwardsiella tarda, Yersinia enterocolitica, Y. pestis, Y. pseudotuberculosis, Shigella TULANE dysenteriae, S. flexneri, S. sonnei, Salmonella typhimurium, Treponema pallidum, T. EDUCATIONAL New adjuvant for oral pertenue, T. carateneum, Borrelia vincentii, Leptospira icterohemorrhagiae, FUND (TULA); WO9947164-A; administration of antigen Mycobacterium tuberculosis, Toxoplasma gondii, Pneumocystis carinii, Francisella US 1998 SMITHKLINE WO9947164-A1 vaccine. tularensis, Brucella abortus, B. suis, B. melitensis, Mycoplasma spp., Rickettsia BEECHAM prowazeki, R. tsutsugumushi, Chlamydia spp., Helicobacter pylori, Coccidioides immitis, (SMIK) Aspergillus fumigatus, Candida albicans, Blastomyces dermatitidis, Cryptococcus neoformans, Histoplasma capsulatum, Entomoeba histolytica, Trichomonas tenas, T. hominis, T. vaginalis, Trypanosoma Cruzi, Leishmania donovani, L. tropica, L. braziliensis, Pneumocystis pneumonia, Enterobius vermicularis, Trichuris trichuria, Ascaris lumbricoides, Trichinella spiralis, Strongyloides stercoralis, Schistosoma japonicum, S. mansoni, S, haematobium, or variola, vaccinia, cowpox, varicella-zoster, Herpes Simplex 1 or 2, influenza, parainfluenza, respiratory syncytial, Hepatitis A, B, C or E, or non-A or non-B hepatitis virus, or measles, mumps or rubella antigen. TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred holotoxin: The mutant LT is encoded by a plasmid which expresses both subunit A and subunit B of LT.Preferred antigen: The antigen is a bacterial, fungal, protozoal, viral, helmenthic or other microbial pathogenic antigen, preferably Streptococcus pyogenes, S. pneumoniae, Neisseria gonorrhoea, N. meningitidis, Corynebacterium diptheriae, Clostridium botulinum, C. perfringens, C. tetani, Haemophilus influenzae, Klebsiella pneumoniae, K. ozaenae, K. rhinoscleromotis, Staphylococcus aureus, Vibrio cholerae, E. coli, Pseudomonas aeruginosa, Campylobacter (Vibrio) fetus, C. jejuni, Aeromonas hydrophila, Bacillus cereus, Edwardsiella tarda, Yersinia enterocolitica, Y. pestis, Y. pseudotuberculosis, WO9947167-A; A new mutant of TULANE Shigella dysenteriae, S. flexneri, S. sonnei, Salmonella typhimurium, Treponema WO9947167-A1; Escherichia coli holotoxin EDUCATIONAL US 1998 pallidum, T. pertenue, T. carateneum, Borrelia vincentii, Leptospira icterohemorrhagiae, AU9930893-A; useful as an adjuvant. FUND (TULA) Mycobacterium tuberculosis, Toxoplasma gondii, Pneumocystis carinii, Francisella US6033673-A tularensis, Brucella abortus, B. suis, B. melitensis, Mycoplasma spp., Rickettsia prowazeki, R. tsutsugumushi, Chlamydia spp., Helicobacter pylori, Coccidioides immitis, Aspergillus fumigatus, Candida albicans, Blastomyces dermatitidis, Cryptococcus neoformans, Histoplasma capsulatum, Entomoeba histolytica, Trichomonas tenas, T. hominis, T. vaginalis, Trypanosoma Cruzi, Leishmania donovani, L. tropica, L. braziliensis, Pneumocystis pneumonia, Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Trichinella spiralis, Strongyloides stercoralis, Schistosoma japonicum, S. mansoni, S, haematobium, or variola, vaccinia, cowpox, varicella-zoster,

136

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. Herpes Simplex 1 or 2, influenza, parainfluenza, respiratory syncytial, Hepatitis A, B, C or E, or non-A or non-B hepatitis virus, or measles, mumps or rubella antigen.Preferred immune response: The immune response is serum, cell-mediated, or mucosal. WO9929341-A; Leishmania braziliensis or CORIXA CORP WO9929341-A2; L. major homologues of the NOVELTY - Leishmania braziliensis or Leishmania major homologues of the eukaryotic (CORI-Non- AU9917249-A; US 1994 eukaryotic ribosomal ribosomal protein eIF4A, designated LbeIF4A and LmeIF4A respectively, are new. standard) US6013268-A; protein eIF4A. US6660840-B1 New Leishmania braziliensis antigen NOVELTY - A new LbeIF4A polypeptide is encoded by a DNA sequence selected from: LbeIF4A - useful for (a) nucleotides 115-1323 (I) of a 1618 bp sequence (full length genomic sequence of CORIXA CORP stimulating a Th1 immune LbeIF4A); or (b) DNA sequences that hybridize to a nucleotide sequence complementary (CORI-Non- US5876966-A US 1994 response in peripheral to (I), where the DNA sequence encodes a polypeptide that stimulates a Th1 immune standard) blood mononuclear cells, response in peripheral blood mononuclear cells (PBMCs) obtained from Leishmania- and as a vaccine for infected individuals. treating Leishmaniasis.

137

TÍTULO DA NÚMERO DA PAÍS ANO RESUMO DA PATENTE DEPOSITANTE PATENTE PATENTE PRIOR. PRIOR. WO9853698-A; EP986309-A; US6183762-B2; WO9853698-A1; AU9875178-A; ZA9804459-A; NO9905802-A; SEMBIOSYS EP986309-A1; GENETICS INC CN1258198-A; (SEMB-Non- BR9809691-A; standard); US6146645-A; DECKERS H M Preparation of an emulsion formulation comprises: (1) obtaining oil bodies from a cell; (2) US6183762-B1; (DECK-Individual); washing the oil bodies to obtain a washed oil body preparation and (3) formulating the US6210742-B1; Preparation of ROOIJEN G V washed oil body preparation into an emulsion. Also claimed is the emulsion formulation. KR2001013047-A; emulsion formulation (ROOI-Individual); NZ501404-A; used in food or feed BOOTHE J (BOOT- The cell is preferably a plant cell obtained from spores, pollen, seed or a vegetative plant AU737896-B; and pharmaceutical Individual); GOLL J organ, particularly seeds from an oil seed plant selected from rapeseed (Brassica spp.), JP2002503268-W; products, etc. - (GOLL-Individual); soybean (Glycine max), sunflower (Helianthus annuus), oil palm (Elaeis guineeis), US2002037303-A1; comprises washing MOLONEY M M US 1997 cottonseed (Gossypium spp.), groundnut (Arachis hypogaea), coconut (Cocus nucifera), US6372234-B1; oil bodies from cell (MOLO-Individual); castor (Ricinus communis), safflower (Carthamus tinctorius), mustard (Brassica spp. and US2002071846-A1; and formulating DALMIA B K Sinapis alba), coriander (Coriandrum sativum), squash (Cucurbita maxima), linseed/flax US2002071852-A1; washed oil body (DALM-Individual); (Linum usitatissimum), Brazil nut (Bertholletia excelsa), jojoba (Simmondsia chinensis) US2002106337-A1; preparation into SCHRYVERS A B and maize (Zea mays). The method comprises grinding plant seeds, removing solids US2002114820-A1; emulsion. (SCHR-Individual); from the ground seeds and separating the oil body phase from the aqueous phase. A IL132908-A; ALCANTARA J liquid phase, preferably water, is added prior to or following the grinding step. RU2200420-C2; (ALCA-Individual); TW505508-A; HUTCHINS W A US6582710-B2; (HUTC-Individual); US6599513-B2; VAN ROOIJEN G US6596287-B2; (VROO-Individual) NO316731-B1; US6761914-B2; MX217186-B; CA2290278-A1; AU200185511-A; CA2290278-C; AU772919-B2

138

TÍTULO DA NÚMERO DA PAÍS ANO RESUMO DA PATENTE DEPOSITANTE PATENTE PATENTE PRIOR. PRIOR. WO9639524-A; EP832236-A; A novel compsn. comprises an antigen or DNA vaccine and an LbeIF4A or LmeIF4A WO9639524-A1; Compositions polypeptide comprising an amino acid sequence encoded by a DNA sequence selected AU9659880-A; comprising LbeIF4A from: (a) nucleotides 115-1323 of the 1618 bp sequence (I) of the Leishmania NO9705730-A; and LmeIF4A braziliensis homologue of the eukaryotic initiation factor 4A (eIF4A) or nucleotides 117- EP832236-A1; polypeptide(s) and CORIXA CORP 1325 of the 1867 bp sequence (II) of the Leishmania major homologue of eIF4A; and (b) CN1194000-A; an antigen or DNA (CORI-Non- DNA sequences which hybridise to the sequences of (a) under moderately stringent US5876735-A; US 1994 vaccine - elicits or standard); REED S conditions; where the DNA sequence encodes a polypeptide that stimulates a Th1 US5879687-A; enhances an G (REED-Individual) immune response in peripheral blood mononuclear cells obtained from a Leishmania- BR9608898-A; immune response infected individual, for use in the manufacture of a medicament for enhancing or eliciting NZ309659-A; against a tumour in a an immune response to an antigen or DNA vaccine in a patient. Also claimed are: (1) an MX9709737-A1; patient. LbeIF4A polypeptide encoded by (I); and (2) an LmeIF4A polypeptide encoded by (II). KR99022654-A; JP2001503014-W; AU200055037-A

139

4. TEMA: PROGRAMAS DE DESCOBERTA

Dentre os termos relacionados ao tema, nos termos clonagem, stem cells e engenharia genética foram localizadas patentes cujos títulos, resumos, depositantes, números da patente, país de prioridade e ano de prioridade são apresentados na tabela a seguir.

140 a. CLONAGEM NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. TECHNOLOGY FOCUS - BIOLOGY - Preferred Components: The host cell is selected from Taraxacum kok-saghyz (russian dandelion), Hevea brasiliensis (rubber tree), Parthenium argentatum (guayule), Helianthus spp. (sunflower), Nicotiana spp. Isolated nucleic acid molecule (tobacco), Lycopersicon spp. (tomato), Solanum spp. (potato), encoding a cis- Cannabis spp. (hemp), Sorghum vulgare (sorghum), Triticum spp. prenyltransferase enzyme for (wheat), Zea mays (maize), Oryza sativa (rice), Secale cereale WO2004044173- transfection of plant cells to DU PONT DE NEMOURS A2; (rye), Avena spp. (oats), Hordeum vulgare (barley), Brassica spp. US 2002 alter rubber production has a & CO E I (DUPO) AU2003295489- sequence of nucleotides as that (rapeseed), Vicia faba (broad bean), Phaseolus vulgaris (french A1 of found in natural rubber bean), Vigna spp. (other bean species), Lens culinaris (lentil), producing plant e.g. sunflower. Glycine max (soybean), Arabidopsis thaliana (arabidopsis), Gossypium hirsutum (cotton), Petunia hybrida (petunia), Linum usitatissimum (flax), Daucus carota sativa (carrot), Aspergillus, Saccharomyces, Pichia, Candida Hansenula, Bacillus, Escherichia, Salmonella and Shigella. TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Vector: The vector comprises a sequence that permits passage of the vector from a first prokaryotic cell to a second prokaryotic cell by direct transfer. The direct transfer is by conjugation. The E. coli origin of replication is Co1E1 and the Actinomycetes origin of replication is pJV1. The first prokaryotic cell is E. coli. The second New vector comprising a prokaryotic cell is Actinomycetes. The second prokaryotic cells is WO2003083087- nucleic acid, an E. coli and Acetobacter xylinum, Achrombacter parvulus, Acinetobacter spp., A; Actinomycetes origin of Aeromonas spp., Agrobacterium spp., Alcaligenes spp., WO2003083087- replication, a cos cosmid Anabaena spp., Azospirrillum brazilense, Azotobacter spp., A1; cloning site, and an origin of WYETH (AMHP) US 2002 US2003224484- transfer, useful for expressing Bordetella spp., Caulobacter spp., Enterobacteriaceae, A1; polypeptides and for Haemophilus influenza, Hypomicrobium X, Legionella AU2003224802- manipulating Actinomycetes pneumophila, Methylophilus methyltrophus, Ethylosinus A1 biosynthesis genes. trichosporium, Myxococcus xanthus, Neisseria spp., Paracoccus denitrificans, Pseudomonas spp., Rhizobium spp., Rhodopseudomonas spp., Rhodospirillum spp., Thiobacillus spp., Vibrio cholerae, Xanthomonas spp., Yersinia enterocolitica, Myxococcusor Bacteroides. The vector has a vector map.Preferred Method: In expressing a polypeptide in a prokaryotic cell, the expressed protein is encoded by a nucleic

141

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. acid having a modified nucleotide sequence, where the expressed protein is a modified protein. The nucleic acid sequence comprises a modification comprising insertion of a heterologous nucleotide sequence, deletion of a nucleotide sequence or alteration of at least one nucleotide within the sequence. The nucleic acid encoding the protein is further incorporated into the second prokaryotic cell genome by homologous recombination. WO2003020016- MONSANTO Novel promoter of soybean A2; TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred TECHNOLOGY LLC (Glycine max) useful for US2003093828- Sequence: In (II), (I) is operably linked to a second nucleic acid (MONS); WANG Q transforming plants, which is A1; EP1440151- (WANG-Individual); US 2001 capable of transcribing sequence which encodes a protein selected from zeins 7S A2; DUBOIS P (DUBO- heterologous nucleic acid protein, brazil nut protein, phenylalanine free protein, beta AU2002341829- Individual); MONSANTO sequences in seeds. conglycinin, 11S protein, alpha-hordothionin, arcelin, seed A1; US6825398- CO (MONS) storage protein, lectin and glutenin. B2 WO2003010294- A; Novel isolated nucleic acid WO2003010294- molecule encoding isopentenyl DU PONT DE NEMOURS A2; diphosphate, IPP, pathway TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Host & CO E I (DUPO); US2003119098- enzyme, useful for obtaining Cell: (IX) is chosen from bacteria, yeast, filamentous fungi, algae HALLAHAN D L (HALL- A1; EP1434784- US 2001 nucleic acid molecule encoding and green plants. Preferably, the host cell is Aspergillus, Individual); KEIPER- A2; IPP pathway enzyme, and for HRYNKO N M (KEIP- Trichoderma, Saccharomyces, Pichia, Candida, etc, or is a rubber AU2002355297- regulating IPP biosynthesis in Individual) tree (Hevea brasiliensis), tobacco (Nicotiana spp.), tomato A1; organism. (Lycopersicon spp.), potato (Solanum spp.), hemp (Cannabis MX2004000645- spp.), etc. A1 TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred DNA: The DNA construct further comprises an operably linked heterologous DNA promoter, and an operably linked 3' regulatory region. One or more of the DNA molecules are in the sense (5'-3') CORNELL RES FOUND WO200282889- INC (CORR); PAIS M S S A; New DNA construct, useful for orientation. The DNA molecules are inserted in the antisense (3'- (PAIS-Individual); WO200282889- controlling the ripening of 5') orientation. The DNA molecules encode a non-translatable GONSALVES D (GONS- A1; papaya fruit and conferring RNA. One or more of the DNA molecules are selected from the US 2001 Individual); BALDE A US2003204869- resistance to papaya ringspot group of the variable regions and conserved regions of the DNA (BALD-Individual); A1; virus coat in transgenic plants. molecules. The DNA molecule that encodes a protein or CHIANG C (CHIA- AU2002307320- polypeptide that controls papaya fruit ripening is selected from a Individual) A1 group of a beta-galactosidase, a pectinmethylesterase, a polygalacturonase, or their combinations. The papaya ringspot virus coat protein DNA molecule is derived from a gene encoding

142

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. a papaya ringspot virus coat protein in a papaya ringspot virus strain selected from the group of Thailand (TH), Kapoho (KA), Mexico (ME), Taiwan (YK), Brazil (BR), Jamaica (JA), Oahu (OA), Venezuela (VE), or their combinations.Preferred Host Cell: The cell is selected from the group of a bacterial cell, a virus, a yeast cell, and a plant cell, where the cell is preferably a plant cell, particularly papaya.Preferred Transgenic Plant: The plant is preferably papaya.Preferred Method: The DNA construct promotes or delays ripening of papaya fruit. Resistance is conferred to a papaya ringspot virus strain selected from the group of TH, KA, ME, YK, BR, JA, OA, and VE. The plant cell transformed is a papaya plant cell. TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Method: (M1) further involves separating (II) from cellular host cell components by selective partitioning into a lipid phase that comprises oil bodies. Preferably, (II) is separated by addition of oil body components and reconstitution of the oil bodies.Preferred Plant: (IV) is rape seed (Brassica spp.), linseed/flax (Linum usitatissimum), safflower (Carthamus tinctorius), sunflower (Helianthus annuus), maize (Zeamays), soybean (Glycine max), mustard (Brassica spp.) and (Sinapis alba), crambe (Crambe Expressing somatotropin in abyssinica), eruca (Erucasativa), oil palm (Elaeis guineeis), plants, for use in e.g. the cottonseed (Gossypium spp.), groundnut (Arachis hypogaea), aquaculture industry, comprises coconut (Cocusnucifera), castor bean (Ricinus communis), MOLONEY M M (MOLO- expressing nucleic acid US2002100073- coriander (Coriandrum sativum), squash, (Cucurbita maxima), Individual); HABIBI H R US 1991 encoding somatotropin linked to A1 (HABI-Individual) nucleic acid encoding oleosin Brazil nut (Bertholletia excelsa) or jojoba (Simmondsia protein to target the fusion chinensis).Preferred Seed: (V) is obtained from a dicotelydenous polypeptide to the lipid phase. plant, where the somatotropin is expressed in the embryogenic tissue of the seed. In (VI), the somatotropin is expressed as a fusion protein. The fusion protein preferably comprises somatotropin and oleosin, and is expressed in the embryogenic tissue of the seed. (VI) is preferably obtained from a dicotelydenous plant as described above, and is an exalbuminous seed.Preferred Fusion Polypeptide: In (VII), the somatotropin is biologically active. (VII) has a fully defined sequence of 366 amino acids, given in the specification.Preferred Nucleic Acid: (III) has a sequence of 1101 nucleotides, given in the specification.

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. The disease is associated with yeast or fungi selected from Candida spp., Aspergillus spp., Microsporum spp., Trichophyton New isolated nucleic acid spp., Fusarium spp., Zygomycetes spp., Botritis spp., WO200264766- representing a synthetic BAX- JANSSEN PHARM NV Cladosporium spp., Malassezia spp., Epidermophyton floccosum, A2; EP1346044- gene, useful as medicament for (JANC); CONTRERAS R H Blastomyces dermatitidis, Coccidioides immitis, Histoplasma A2; treating, preventing and/or (CONT-Individual); capsulatum, Paracoccidioides brasiliensis, Cryptococcus AU2002249105- EP 2000 alleviating yeast or fungal EBERHARDT I (EBER- A1; infections or proliferative neoformans, and Sporothrix schenckii. Identifying compounds for Individual); REEKMANS R US2004161840- disorders, or for preventing stimulating or inhibiting apoptosis comprises the use of at least J (REEK-Individual) A1 apoptosis in certain diseases. one of (IV) or its human homologue and/or at least one of (III) or its human homologue and/or the genetically modified mammalian cell or non-human organism. The plant also includes Dactylis glomerata, Poa palustris, P. pratensis, Bromus catharticus, B. sitchensis or Miscanthus spp. The transgenic plant also includes woody species such as New tissue specific plant Populus spp., Eucalyptus spp., Hevea spp. (e.g. H. brasiliensis), promoter, specifically for Lolium Quercus spp., Betula spp., Fagus spp., Fraxinus spp., Ulmus WO200250294- perenne cinnamoyl CoA:NADP spp., Liriodendron spp., Liquidambar spp. or Robinia spp.. The DANMARKS A; oxidoreductase, useful for gymnosperm includes conifers such as Pinus spp. (e.g. P. taeda, JORDBRUGSFORSKNING WO200250294- DK 2000 manipulating lignin biosynthesis (DAJO-Non-standard) A1; in plants or regulating gene P. radiata, P. silvestris, P. lambertiana, P. elliotti, P. palustris), AU200221582-A expression in lignin-producing Picea spp. (e.g. P. abies, P. rubra, P. stichensis, P. mariana, P. tissues of plants. glauca), Larix spp. (e.g. L. leptolepis, L. decidua, L. occidentalis, L. laricina), Abies spp. (e.g. A. grandis, A. fraserii, A. concolor, A. procera, A. balsamea), Pseudotsuga spp. (e.g. P. menziesii), Tsuga spp., Thuja spp. TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Transgenic plants for the somatotropin: Preferably the somatotropin is a fish growth farming industry and for hormone, more preferably carp growth hormone. Preferably plant: providing somatotropins such The transformed plant is preferably rapeseed, linseed, safflower, SEMBIOSYS GENETICS as fish growth hormone, sunflower, maize, soybean, mustard, crambe, eruca, oil palm, US6288304-B1 US 1991 INC (SEMB-Non-standard) comprise a chimeric nucleic cottonseed, groundnut, coconut, castor bean, coriander, squash, acid encoding a somatotropin brazil nut or jojoba. Preferred plant seed: The seed is preferably and an oleosin fragment. from a dicot plant where the somatotropin is expressed in the embryogenic tissue and is fish growth hormone. The hevein (Hevea brasiliensis) coding region (HEV1) was WO9961635-A; New cotton cells expressing YENOFSKY R L; FINE M; ligated to plant cloning vector pGA643 which contains the CaMV EP1080214-A; heterologous genes for pest RANGAN T S; US 1998 WO9961635-A2; resistance. 35S promoter. PGA643 can be obtained from Dr. N. Raikhel, ANDERSON D M MSU-DOE Plant Research Lab, Michigan State University, MI, AU9943172-A;

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. 48824. The plasmid was transformed into cotton cell suspensions, BR9910777-A; grown and selected for positive colonies using ELISA. Positive EP1080214-A2; cell cultures were incubated with newly hatched corn ear worm CN1303441-A; larvae, and after 7 days the average larval weight increase was ZA200006380-A; MX2000011754- 95% of the controls. A1; AU750527-B; US2004016019- A1; US6710228- B1

b. STEM CELLS

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. The fungi is selected from Acremonium spp., Aspergillus spp., Basidiobolus spp., Bipolaris spp., Blastomyces dermatidis, Candida spp., Cladophialophora carrionii, Coccoidiodes immitis, Conidiobolus spp., Cryptococcus spp., Curvularia spp., Epidermophyton spp., Exophiala Generating a jeanselmei, Exserohilum spp., Fonsecaea compacta, Fonsecaea population of pedrosoi, Fusarium Oxysporum, Fusarium solani, Geotrichum candidum, dendritic cells, useful Histoplasma capsulatum var. capsulatum, Histoplasma capsulatum var. CORP ORDER for inducing duboisii, Hortaea werneckii, Lacazia loboi, Lasiodiplodia theobromae, SISTERS OF MERCY protective immune Leptosphaeria senegalensis, Madurella grisea, Madurella mycetomatis, IN QUEENSLAN WO2004020613- response against Malassezia furfur, Microsporum spp., Neotestudina rosatii, Onychocola (ORDE-Non-standard); A1; infections, cancers or Canadensis, Paracoccidioides brasiliensis, Phialophora verrucosa, AU 2002 ORDER OF SISTERS AU2003254412- autoimmune Piedra iahortae, Piedra iahortae, Pityriasis versicolor, Pseudallesheria OF MERCY IN A1 diseases by culturing boydii, Pyrenochaeta romeroi, Rhizopus arrhizus, Scopulariopsis QUEENSLAND or expanding CD34+ brevicaulis, Scytalidium dimidiatum, Sporothrix schenckri, Trichophyton (ORDE-Non-standard) precursor cells in the spp., Trichosporon spp., Zygomcete fungi, Absidia corymbifera, presence of one or Rhizomucor pusillus and Rhizopus arrhizus. The bacteria are selected more cytokines. from of Bacillus anthracis, Bordetella pertussis, Vibrio cholerae, Escherichia coli, Shigella dysenteriae, Clostridium perfringens, Clostridium botulinum, Clostridium tetani, Corynebacterium diphtheriae, Pseudomonas aeruginosa, Bacillus anthracis, Bordetella Pertussis, Staphylococcus aureus and Streptococcus pyogenes.

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. The regulatable promoter sequence comprises:(i) a cinnamoyl alcohol dehydrogenase gene promoter sequence;(ii) a laccase gene promoter sequence;(iii) a cellulose synthase gene promoter sequence; or(iv) a Modifying plant xyloglucan endotransglucosylase.Preferably, the promoter sequence is morphological, the auxin-inducible SAUR or the rolB promoter sequence. Specifically, biochemical and/or the woody plant is Eucalyptus spp., Populus spp., Quercus spp., Acer, physiological traits, Juglans spp., Fagus spp., Acacia spp. or teak. The expression of Cdc25 e.g. enhancing grain under the control of a regulatable promoter sequence that is operable in WO200052171- CROPDESIGN NV yield, by expressing the seed (preferably the endosperm of the seed) of a plant, or the cell , A; (CROP-Non-standard); Cdc25 tissue or organ of the seed, will result in modified characteristics WO200052171- US 1999 UNIV AUSTRALIAN phosphoprotein consisting of:(i) enhanced seed set and size;(ii) enhanced grain yield; A1; NAT (AUSU) phosphatase in the or(iii) enhanced endoreduplication in the seed of the plant.The AU200027859-A plant operably under regulatable promoter comprises a promoter sequence of the following the control of a genes: barley Amy32b, a Cathepsin beta-like gene, wheat ADP-glucose regulatable promoter pyrophosphorylase, maize zein, rice glutelin, legumin, NapA, Brazil Nut sequence. albumin, pea vicilin, sunflower oleosin, barley ltr1 gene, or barley Hor2. The regulatable promoter sequence may also comprise a rice prolamin NRP33 promoter sequence, or a synthetic promoter that contains a rice REB gene promoter sequence.

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c. ENGENHARIA GENÉTICA NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. The nucleic acids, polypeptides, antibodies and compounds which bind to and modulate the expression or functionality of the polypeptides are useful for preparing medicaments for treating diseases associated with yeast and fungi infections, WO200102550- such as diseases caused by Candida spp. (especially C. A; albicans when using antibodies as a medicament), EP1196635-A; Aspergillus spp., Microsporum spp., Trichophyton spp., WO200102550- Fusarium spp., Zygomycetes spp., Botritis spp., A2; Yeast and fungal nucleic acids encoding Cladosporium spp., Malassezia spp., Epidermophyton AU200057984- proteins involved in a pathway leading floccosum, Blastomyces dermatitidis, Coccidioides immitis, A; JANSSEN to programmed cell death, useful for Histoplasma capsulatum, Paracoccidioides brasiliensis, NO200200011- PHARM NV EP 1999 treating proliferative disorders, yeast Cryptococcus neoformans or Sporothrix schenckii.The A; (JANC) and fungal infections, or for preventing genetically modified yeast or fungus is useful in the EP1196635-A2; apoptosis in certain diseases. preparation of a medicament for modifying endogenic flora of JP2003504013- humans and other mammals.They are also useful for treating W; proliferative disorders or for preventing apoptosis in certain KR2003000012- diseases (all claimed). The medicaments are useful for A; treating humans and plants having the yeast or fungal NZ515568-A; infections.The nucleic acids and polypeptides represent ZA200110481-A potential targets for the identification of new compounds which can be used in alleviating diseases or conditions associated with yeast or fungal infections.

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5. TEMA: SUSTENTABILIDADE AMBIENTAL

Para este tema não foram localizadas patentes que citam explicitamente o Brasil no título/resumo. Dentre os termos relacionados ao tema, nos termos OGM e Controle Biológico foram localizadas patentes, cujos títulos, resumos, depositantes, números da patente, país de prioridade e ano de prioridade são apresentados na tabela a seguir.

148 a. TERMO: OGM PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR.

DU PONT DE Novel isolated nucleic acid molecule TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Host NEMOURS & CO WO2003010294-A; encoding isopentenyl diphosphate, Cell: (IX) is chosen from bacteria, yeast, filamentous fungi, algae E I (DUPO); WO2003010294-A2; IPP, pathway enzyme, useful for and green plants. Preferably, the host cell is Aspergillus, HALLAHAN D L US2003119098-A1; obtaining nucleic acid molecule Trichoderma, Saccharomyces, Pichia, Candida, etc, or is a rubber US 2001 (HALL-Individual); EP1434784-A2; encoding IPP pathway enzyme, and tree (Hevea brasiliensis), tobacco (Nicotiana spp.), tomato KEIPER-HRYNKO AU2002355297-A1; for regulating IPP biosynthesis in (Lycopersicon spp.), potato (Solanum spp.), hemp (Cannabis N M (KEIP- MX2004000645-A1 organism. spp.), etc. Individual)

TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred DNA: The DNA construct further comprises an operably linked heterologous DNA promoter, and an operably linked 3' regulatory region. One or more of the DNA molecules are in the sense (5'-3') orientation. The DNA molecules are inserted in the antisense (3'- 5') orientation. The DNA molecules encode a non-translatable RNA. One or more of the DNA molecules are selected from the group of the variable regions and conserved regions of the DNA CORNELL RES molecules. The DNA molecule that encodes a protein or FOUND INC polypeptide that controls papaya fruit ripening is selected from a (CORR); New DNA construct, useful for group of a beta-galactosidase, a pectinmethylesterase, a PAIS M S S (PAIS- WO200282889-A; controlling the ripening of papaya polygalacturonase, or their combinations. The papaya ringspot Individual); WO200282889-A1; fruit and conferring resistance to virus coat protein DNA molecule is derived from a gene encoding GONSALVES D US 2001 US2003204869-A1; papaya ringspot virus coat in a papaya ringspot virus coat protein in a papaya ringspot virus (GONS-Individual); AU2002307320-A1 transgenic plants. strain selected from the group of Thailand (TH), Kapoho (KA), BALDE A (BALD- Mexico (ME), Taiwan (YK), Brazil (BR), Jamaica (JA), Oahu (OA), Individual); Venezuela (VE), or their combinations.Preferred Host Cell: The CHIANG C (CHIA- cell is selected from the group of a bacterial cell, a virus, a yeast Individual) cell, and a plant cell, where the cell is preferably a plant cell, particularly papaya.Preferred Transgenic Plant: The plant is preferably papaya.Preferred Method: The DNA construct promotes or delays ripening of papaya fruit. Resistance is conferred to a papaya ringspot virus strain selected from the group of TH, KA, ME, YK, BR, JA, OA, and VE. The plant cell transformed is a papaya plant cell.

149 b. TERMO: CONTROLE BIOLÓGICO

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Vaccine: The antigen is derived from Epidermophyton floccusum, Microsporum audouini, M. canis, M. distortum, M. equinum, M. gymsum, M. nanum, Trichophyton centricum, T. equinum, T. gallinae, T. gypseum, T. megnin, T. mentragrophytes, T. quinckeanum, T. rubrum, T. schoenleini, T tonsurans, T. verrucosum, T. verrucosum var. album, var. discoides, var. ochraceum, T. violaceum, and/or T. faviforme, Aspergillus fumigatus, A. flavus, A. niger, A. nidulans, A. terreus, A. sydowi, A. flavatus, A. glaucus, Blastoschizomyces capitatus, Candida albicans, C. enolase, C. tropicalis, C. glabrata, C. krusei, C. WO2003018051- New multivalent vaccine parapsilopsis, C. stelatoidea, C. kusei, C. parakwsei, C. lusitaniae, C. A; comprising one or more heat- pseudotropicalis, C. guilliermondi, C. carrionii, Coccidioides immitis, JIRA V (JIRA- US2003039667- inactivated fungal pathogens, Blastomyces dermatidis, Cryptococcus neoformans, Geotrichum Individual); A1; US 2001 useful for treating and preventing clavatum, Histoplasma capsulatum, Klebsiella pneumoniae, JIRATHITIKAL V WO2003018051- fungal infections, and for inducing Paracoccidioides brasiliensis, Pneumocystis carinii, Pythium (JIRA-Individual) A1; immunity to fungal pathogens. insidiosum, Pityrosporum ovale, Saccharomyces cerevisiae, S. AU2002326766- boulardii, S. pombe, Scedosporium apiosperum, Sporothrix A1 schenckii, Trichosporon beigelii, Toxoplasma gondii, Penicillum marneffei, Malassezia spp., Fonsecaea spp., Wangiella spp., Sporothrix spp., Basidiobolus spp., Conidiobolus spp., Rhizopus spp., Mucos spp., Absidia spp., Mortierella spp., cunninghamella spp. or Saksenaea spp.. The inactivated pathogen of the oral vaccine is a fungus or its part.Preferred Immunogen: The immunogen is administered to the host without an immune adjuvant. The immune response is directed against fungal infection. The amount of immunogen comprised in the pill is 0.0000001-20 % by weight.

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR.

DETAILED DESCRIPTION - Preparation (A) for treating soil or seeds contains at least one live microorganism (B) that can propagate in WO2003016241- AGRO BIO A; different types of soil in the environment of a plant and a wet or dry HUNGARY KFT WO2003016241- carrier. (B) is 5x100000-1011, particularly 107-1010, cells/g of at (AGRO-Non- Composition for treating soil or A1; least one of Azospirillium brasiliense ssp. SW51; Azobacter vinelandi standard); BIOFIL seeds, useful e.g. for improving HU200103294- ssp. M657; Pseudomonas fluorescens var. SW11; Bacillus polymyxa KFT (BIOF-Non- plant growth and soil structure, is A1; HU 2001 standard); mixture of specific var. SW17; Bacillus megaterium var. M326; Micrococcus roseus ssp. AU2002321675- AGRO.BIO microorganisms. A21; Bradyrhizobium japonicum var. PH25 and/or Streptomyces A1; HUNGARY KFT album var. 0003LP, deposited as NCAIM/P/B 001293; 001292; KR2004032915- (AGRO-Non- 001296; 001295; 001291; 001294; 001302 and 001301, respectively. A; BR200211920- standard) These are able to grow at low temperatures, preferably below 20 A degrees C, and low pH, preferably below pH 5.0.

Microbial medium for growing agronomically beneficial microbes For growing agronomically beneficial microbes such as Azospirillum, to preset density such as Bacillus, Pseudomonas, Rhizobia, phototrophic and cellulose TATKO BIOTECH Azospirillum, comprises aqueous degrading bacteria, Clostridium, Trichoderma, Azospirillum INC (TATK-Non- US6468779-B1 US 1998 extract of legumes prepared by brasilense and Azospirillum brasilense SAB MKB NRRL B-30082 standard) boiling legumes in water and and B-30081 strains. removing solids. Biocontrol composition useful for NOVELTY - A biocontrol composition (I) comprises a mixture of at inhibiting development of plant EMPRESA BRASIL least 1 microorganism (especially a bacteria e.g. Pantoea US2002119124- pathogenic diseases such as PESQUISA agglomerans and Bacillus megaterium) which is an antagonist A1; Fusarium Head Blight, comprises a AGROPECUARIA BR 2000 BR200009629-A; mixture of microorganisms e.g. against plant pathogens and a carrier for the microorganism (the (EMPR-Non- US6599503-B2 Pantoea agglomerans and Bacillus microorganism is present in an amount effective for inhibiting plant standard); megaterium, and a carrier. pathogen development), is new.

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. TECHNOLOGY FOCUS - BIOLOGY - Preferred Microorganism: The preferred (M1) is a fungus preferably pathogenic and is selected from the (S) Absidia, Actinomadura madurae, Actinomyces, Allescheria boydii, Alternaria, Anthopsis deltoidea, Aphanomyces , Apophysomyces eleqans, Armillaria , Arnium leoporinum, Aspergillus ., Aureobasidium pullulans, Basidiobolus ranarum, Bipolaris , Blastomyces dermatitidis, Botrytis , Candida , Centrospora , Cephalosporium , Ceratocystis , Chaetoconidium , Chaetomium , cladosporium , Coccidioides immitis, Colletotrichum , Conidiobolus , Corynebacterium tenuis, Cryptoporiopsis , Cylindrocladium , Cryptococcus , Cunninghamella bertholletiae, Curvularia , Dactylaria , Diplodia , Epidermophyton , Epidermophyton floccosum, WO9953762-A; Exserophilum , Exophiala , Fonsecaea , Fulvia , Fusarium , MICROBIA INC EP1071334-A; Geotrichum, Guignardia , Helminthosporium , Histoplasma , (MICR-Non- WO9953762-A1; Selective biological control of standard); AU9936443-A; Lecythophora , Macrophomina , Madurella , Magnaporthe , US 1998 microorganisms. WHITEHEAD INST EP1071334-A1; Malassezia furfur, Microsporum , Monilinia , Mucor , BIOMEDICAL RES JP2002512007- Mycocentrospora acerina, Nectria , Nocardia , Oospora , Ophiobolus (WHED) W; US6440409- , Paecilomyces , Paracoccidiodides brasiliensis, Pencillium , B1; AU763134-B Phaeosclera dematioides, Phaeoannellomyces , Phialemonium obovatum, Phialophora , Phlyctaena , Phoma , Phomopsis , Phymatotrichum , Phytophthora , Pythium , Piedraia hortai, Pneumocystis carinii, Puccinia , Pythium insidiosum, Rhinocladiella aquaspersa, Rhizomucor pusillus, Rhizoctonia , Rhizopus , Saccharomyces , Saksenaea vasiformis, Sarcinomyces phaeomuriformis, Scerotium , Sclerotinia , Sphaerotheca , Sporothrix schenckii, Syncephalastrum racemosum, Taeniolella boppii, Taphrina , Thielaviopsis , Torulopsosis , Trichophyton , Trichosporon , Ulocladium chartarum, Ustilago , Venturia , Verticillium , Wangiella dermatitidis, Whetxelinia , and Xylohypha and their synonyms.

152

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. TECHNOLOGY FOCUS - BIOLOGY - Preferred Microorganism: The preferred (M1) is a fungus preferably pathogenic and is selected from the (S) Absidia, Actinomadura madurae, Actinomyces, Allescheria boydii, Alternaria, Anthopsis deltoidea, Aphanomyces , Apophysomyces eleqans, Armillaria , Arnium leoporinum, Aspergillus ., Aureobasidium pullulans, Basidiobolus ranarum, Bipolaris , Blastomyces dermatitidis, Botrytis , Candida , Centrospora , Cephalosporium , Ceratocystis , Chaetoconidium , Chaetomium , cladosporium , Coccidioides immitis, Colletotrichum , Conidiobolus , Corynebacterium tenuis, Cryptoporiopsis , Cylindrocladium , Cryptococcus , Cunninghamella bertholletiae, Curvularia , Dactylaria , Diplodia , Epidermophyton , Epidermophyton floccosum, Microorganism raw material for Exserophilum , Exophiala , Fonsecaea , Fulvia , Fusarium , crop cultivation - contains Geotrichum, Guignardia , Helminthosporium , Histoplasma , IDEMITSU KOSAN predetermined amount of water Lecythophora , Macrophomina , Madurella , Magnaporthe , JP11266857-A JP 1998 CO LTD (IDEK) component and Azospirillum Malassezia furfur, Microsporum , Monilinia , Mucor , brasilense in a carrier. Mycocentrospora acerina, Nectria , Nocardia , Oospora , Ophiobolus , Paecilomyces , Paracoccidiodides brasiliensis, Pencillium , Phaeosclera dematioides, Phaeoannellomyces , Phialemonium obovatum, Phialophora , Phlyctaena , Phoma , Phomopsis , Phymatotrichum , Phytophthora , Pythium , Piedraia hortai, Pneumocystis carinii, Puccinia , Pythium insidiosum, Rhinocladiella aquaspersa, Rhizomucor pusillus, Rhizoctonia , Rhizopus , Saccharomyces , Saksenaea vasiformis, Sarcinomyces phaeomuriformis, Scerotium , Sclerotinia , Sphaerotheca , Sporothrix schenckii, Syncephalastrum racemosum, Taeniolella boppii, Taphrina , Thielaviopsis , Torulopsosis , Trichophyton , Trichosporon , Ulocladium chartarum, Ustilago , Venturia , Verticillium , Wangiella dermatitidis, Whetxelinia , and Xylohypha and their synonyms.

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. WO200034440- A; US5951978-A; WO200034440- A1; Microbial inoculant useful for NOVELTY - A microbial inoculant (I) comprising Azospirillum TATKO BIOTECH AU200019349-A; improving soil quality and INC (TATK-Non- EP1135462-A1; US 1998 increasing plant production. brasilense SAB MKB effective for application to a plant or soil is new. standard) BR9916134-A; JP2002531117- W; MX2001005785- A1

Composition used to control diseases in gramineous crops comprises microorganisms of genus Chaetomium. Also claimed are the control of diseases in gramineous crops by spraying the composition on gramineous crop plants and strains of genus Chaetomium capable of controlling diseases in gramineous crops.

Disease control composition for The composition preferably contains cell bodies and/or metabolites of gramineous crops - comprises JAPAN TOBACCO microorganisms of genus Chaetomium that have the capability to JP10001407-A JP 1996 microorganisms of genus INC (NISB) Chaetomium. control diseases in crops of family Graminaceae. The microorganisms are Chaetomium brasiliense JT-866, C. cochlioides JT-867, C. spirale JT-868 and/or C. globosum JT-869. The strains, aerobic ascomycetes, can be cultured at 15-33 (preferably 23-25)C, at pH 3-10 (preferably 5-7), for 2-3 weeks. The cell bodies and/or metabolites can be used directly, or prepared as liquid, wettable powder, powder, granule or emulsion using solid or liquid carriers.

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NÚMERO DA PAÍS ANO TÍTULO DA PATENTE RESUMO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR.

Microorganism formulation for Leguminosae plant contains Azospirillum brasilense NI-10 strain and root nodule bacteria.

The ratio of the number of cells of Azospirillum brasilense NI-10 Microorganism formulation for strain and that of the root nodule bacteria is pref. 0.1-10. 105-1012 promoting growth of Leguminosae cells of Azospirillum brasilense NI-10 strain and root nodule bacteria IDEMITSU KOSAN JP8109109-A; plant - contains Azospirillum JP 1994 CO LTD (IDEK) JP3574686-B2 brasilense NI-10 strain and root are pref. contained in 1g of the formulation. The water content in the nodule bacteria. formulation is pref. 5-97 wt.%.

ADVANTAGE - The microorganism formulation has good growth promoting effect and prod. weight increasing effect for Leguminosae plant.

Microorganisms for culturing Culture soln. of tomato contains Azospirillum genera microorganisms, tomato growth stimulation of partic. Azospirillum brasilence, esp. NI-6 (FERM P-13585), NI-8 NORINSUISANSHO tomatoes - involves adding (FERM P-13586), NI-9 (FERM P-13587), or NI-10 (FERM P-13588) NOGYO SEIBUTSU Azospirillum microorganism obtd. strains, isolated by culturing rhizosphere microorganisms in nitrogen- SHIGEN (NORQ); JP6311826-A JP 1993 by culturing rhizosphere free medium; screening nitrogenase active and forming red colonies IDEMITSU KOSAN microorganisms in nitrogen-free in Congo red contg. medium, and g growth stimulative for tomato, in CO LTD (IDEK) medium. culture medium.

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III. Patentes depositadas no Brasil

A tabela a seguir mostra a freqüência das patentes depositadas no Brasil para os temas e termos deste estudo.

Depositadas no TEMAS/TERMOS Brasil TEMA: Biodiversidade/ Bioprospecção Termos da Biodiversidade/ Bioprospecção Fitomedicamentos 4 TEMA: Bioeconomia 1 TEMA: Bioindústria 72 Termos da Bioindústria Designing 3 TEMA: Biorremediação 2 TEMA: Certificação de qualidade biológica Certificação de qualidade biológica Coleções certificadas 1 TEMA: Fertilidade e reprodução animal Termos da Fertilidade e reprodução animal Clonagem 3 TEMA: Integração: alimentação, nutrição e saúde 3 Nutracêuticos (Alimentos 7 Termos da Integração: alimentação, Funcionais) nutrição e saúde Produção de Vacinas em Plantas e 7 Animais TEMA: Programas de Descoberta Clonagem 25 Stem Cells 32 Termos da Programas de Descoberta Engenharia Genética 9 Nanobiotecnologia 1 TEMA: Sustentabilidade Ambiental Bioinseticidas 69 Termos da Sustentabilidade Ambiental Biofungicidas 13

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1. TEMA: BIODIVERSIDADE/BIOPROSPECÇÃO

Para o tema Biodiversidade/Bioprospecção não foram localizadas patentes depositadas no Brasil. Dentre os termos relacionados ao tema, no termo fitomedicamentos foram localizadas 4 patentes depositadas no Brasil, cujos títulos, depositantes, números da patente, país de prioridade e ano de prioridade são apresentados na tabela a seguir.

a. TERMO: FITOMEDICAMENTOS

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. Preparing a phytotherapeutic composition CHEMAS R C for treating Alzheimer's disease by BR200004807- (CHEM- BR 2000 processing asclepiadacea fruit, gives a A Individual) high rate of symptom remission. Phytotherapeutical compound for treatment DARC DE of venous ulcer and is formed from ALVARENGA J BR200106527- BR 2001 substances extracted from herbs and/or (DALV- A medicinal plants. Individual) SOC ESPIRITA Phytotherapeutic formula for neoplasia NUNES MARIA BR200203084- treatment, comprises a composition BR 2002 (ESPI-Non- A preventing new tumor formation. standard) Hyposensitizing phytotherapeutic breathing TEIXEIRA J P aid - comprises medicine extracted from BR9801953-A BR 1998 (TEIX-Individual) resin of cordia.

2. TEMA: BIOECONOMIA

Apresenta-se a seguir o título da patente depositada no Brasil, sobre o tema bioeconomia, com seu respectivo título, depositante, número da patente, país de prioridade e ano de prioridade.

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO9902692-A; Temperature-sensitive dtsR genes EP1002866-A; encoding surfactant-resistant, WO9902692-A1; temperature-sensitive and biotin- AU9879374-A; inhibitory proteins - useful for AJINOMOTO EP1002866-A1; transforming mutant Corynebacteria CO INC JP 1997 BR9810990-A; with surfactant resistance, in stable (AJIN) CN1265702-A; and economic fermentation JP11508433-X; production of L-glutamic acid and L- AU732093-B; lysine. US2003077765-A1

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3. TEMA: BIOINDÚSTRIA

Na tabela a seguir são listados os títulos das patentes depositadas no Brasil, sobre o tema bioindústria, com seus respectivos títulos, depositantes, números da patente, país de prioridade e ano de prioridade.

158

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. A collagen product extracted from the WO200138396-A; WO200138396-A1; skin of cold water fish in paste form, NEW ZEALAND INST CROP & FOOD RES LTD AU200119027-A; BR200016032-A; useful as a fining agent for the (NZCR-Non-standard) MACDONALD G A EP1233985-A1; NZ501386-A; NZ 1999 brewing and wine industries, or as a (MACD-Individual) HOFMAN K (HOFM-Individual) US2003004315-A1; JP2003514919-W; foodstuff, medicament, nutraceutical CN1402736-A; NZ519878-A or cosmetic. A novel glutathione synthase-lacking EP1201747-A; WO200190310-A1; AJINOMOTO CO INC (AJIN) AJINOMOTO KK Saccharomyces cerevisiae useful for BR200106663-A; EP1201747-A1; (AJIN) NISHIUCHI H (NISH-Individual) SANO K producing gamma-glutamylcysteine KR2002019564-A; CN1386134-A; JP 2000 (SANO-Individual) SUGIMOTO R (SUGI- and then cysteine for application in US2003124684-A1; JP2001587106-X; Individual) UEDA Y (UEDA-Individual) food industry to improve flavor. EP1201747-B1 Anaerobic system for treating urban garbage, agro-industrial residues, and SANAB SANEAMENTO AMBIENTAL E biomass comprises inoculate BIOTECNOLOG (SANA-Non-standard) SANAB WO200245725-A; WO200245725-A1; BR 2000 composed of microorganisms whose SANEAMENTO AMBIENTAL & BIOTECNOLOG AU200221358-A; BR200006628-A cultures are maintained in a (SANA-Non-standard) laboratory. Austenitic stainless steel sheet for EP951954-A1; FR2777811-A1; NO9901912- vats used in wine fermentation, milk UGINE SA (UGIN) USINOR (UNSI) A; AU9923841-A; CA2269430-A1; FR 1998 processing, pharmaceutical industry BR9903052-A; MX9903744-A1 and hospitals. Bio-fouling monitor for aqueous WO200034758-A; EP1141674-A; systems including industrial water WO200034758-A1; AU200020381-A; systems, comprises column in BR9916958-A; EP1141674-A1; US6311546- BUCKMAN LAB INT INC (BUCL) US 1998 between inlet and exit pressure B1; CN1330768-A; JP2002532071-W; sensors, microorganism nutrient ZA200104394-A; AU757998-B; pump and optionally heating system. MX2001005806-A1; NZ512124-A Capsules comprise a mineral outer WO200025761-A; EP1124542-A; layer and a liquid core in which is a WO200025761-A1; FR2785292-A1; biologically active material for use in RHODIA CHIM (RHOD) AU9963469-A; EP1124542-A1; BR9914907- FR 1998 the fermentation, biomedical, food, A; JP2003515310-W; AU764016-B; and chemical industries. NZ511365-A Carboxy(alkyl)-cyclopentanone or EP743985-A; WO9618742-A; WO9618742- cyclopentenone deriv. prepn. - A1; EP743985-A1; BR9408528-A; FIRMENICH SA (FIRM) WOIB 1994 comprises microbial beta-oxidn. of US5667995-A; JP9509331-W; EP743985-B1; side-chain of higher homologue, DE69426126-E

159

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. useful in perfume or fragrance industry. WO9531975-A; EP717989-A; WO9531975- Coating of droplets or particles of A1; ES2078190-A1; AU9475379-A; nano-meter - by mixing and NO9600232-A; EP717989-A1; BR9407333- LAB CUSI SA (CUSI-Non-standard) ALCON immediate spray-drying of solns. A; FI9601348-A; ES2078190-B1; ES 1994 CUSI SA (ALCO-Non-standard) contg. active ingredients and coating JP9501101-W; CN1130868-A; AU696400-B; polymer. US5851452-A; EP717989-B1; DE69426568- E Composition for inhibiting growth of EP875145-A; US5785867-A; EP875145-A2; microorganisms, in industrial process NO9801904-A; AU9863607-A; CA2236160- water - comprises peracetic acid and A; NZ330265-A; JP11035410-A; ZA9803525- non-oxidising biocide selected from 2- NALCO CHEM CO (NALC) US 1997 A; BR9801495-A; KR98081830-A; methyl-4,5-tri:methylene-4-iso- MX9803340-A1; AU735264-B; CA2236160- thiazolin-3-one and 2-(thio-cyano- C; TW520272-A methyl-thio)benzothiazole. Controlling sex ratio of mammalian PIG IMPROVEMENT CO UK LTD (PIGI-Non- EP1272030-A; WO200132008-A1; offspring by inserting a transgene that standard) MILEHAM A (MILE-Individual) NABEEL AU200111591-A; BR200015313-A; prevents normal sperm function, GB 1999 A (NABE-Individual) GRAHAM P (GRAH- EP1272030-A1; CN1402612-A; useful in the agricultural industry, Individual) US2003087860-A1 particularly cattle and pig farming. Culture medium useful for detecting fungi and/or yeast in food industry installations, has specific amounts of COCA-COLA FEMSA BUENOS AIRES SA monobasic potassium phosphate, US2004157315-A1; BR200305481-A AR 2002 (COKE) ammonium chloride, heptahydrate magnesium sulfate, saccharose and water. Degradation of microbial WO200123534-A; EP1224269-A; polysaccharides useful in the process WO200123534-A1; FI9902095-A; industry e.g. paper by contacting VALTION TEKNILLINEN TUTKIMUSKESKUS AU200074244-A; BR200014375-A; FI 1999 polysaccharides with an enzyme (VALW) EP1224269-A1; FI109921-B1; ZA200202840- preparation comprising endo-beta- A 1,2-galactanase. Efficient secretory production of WO200123591-A; WO200123591-A1; AJINOMOTO CO INC (AJIN) AJINOMOTO KK foreign proteins e.g. transglutaminase AU200074494-A; BR200014059-A; JP 2000 (AJIN) employing transformant coryneform EP1219713-A1; KR2002038787-A;

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. bacterium, simply on industrial scale CN1377413-A; JP2001526973-X; with direct recovery for use in food US2003082746-A1; RU2224796-C2 processing and pharmaceutical industry. Efficient, cheap production of L- glutamic acid, especially for food and WO9907853-A; EP1004671-A; WO9907853- pharmaceutical industries - by A1; AU9885615-A; EP1004671-A1; AJINOMOTO CO INC (AJIN) JP 1997 culturing Corynebacterium strain in BR9811151-A; CN1275165-A; AU742609-B; liquid medium for accumulation in JP2000506337-X culture medium and then harvesting. Enhancing the production of protein or peptide, for e.g. an industrial UNIV GEORGIA RES FOUND INC (UYGE-Non- WO200127258-A; EP1235903-A; enzyme (e.g. amylase) or a research standard) EITEMAN M A (EITE-Individual) WO200127258-A2; AU200112068-A; or diagnostic enzyme (e.g. DNA US 1999 ALTMAN E (ALTM-Individual) GOKARN R R BR200014758-A; EP1235903-A2; polymerase), by transforming a host (GOKA-Individual) JP2003511067-W; MX2002003634-A1 cell with a nucleic acid encoding a pyruvate carboxylase enzyme. Enzymatic bleach composition useful UNILEVER NV (UNIL) UNILEVER PLC (UNIL) WO200100769-A; EP1187899-A; in fabric washing pulp bleaching in the HINDUSTAN LEVER LTD (HIND-Non-standard) WO200100769-A1; AU200055308-A; EP 1999 paper industry comprises a phenol BREEL G J (BREE-Individual) UNILEVER HOME US6323014-B1; EP1187899-A1; oxidizing enzyme and an enhancer. & PERSONAL CARE USA DIV CO (UNIL) BR200011820-A; ZA200109306-A WO9837179-A; WO9837179-A2; Fermentative production of valuable GIST-BROCADES BV (KONN) DSM NV (STAM) AU9864000-A; EP970236-A2; CZ9902954- compound(s) - by fermentation of a DE LAAT W T A M (DLAA-Individual) A3; BR9807362-A; CN1248294-A; microbial strain on an industrial scale EP 1997 PREUSTING J C G (PREU-Individual) KOEKMAN KR2000075487-A; MX9907691-A1; using a chemically defined medium B P (KOEK-Individual) JP2001512970-W; US2002039758-A1; and recovery of the compound(s). CN1495259-A WO9845403-A; EP979269-A; WO9845403- A1; ZA9800412-A; AU9851342-A; Fermenter for wine industry - NZ331923-A; EP979269-A1; AU715195-B; comprises vat with diaphragm to CASTLE COMML ENTERPRISES LTD (CAST- CN1254372-A; US6125736-A; BR9714566- retain fermentation gas bubbles to ITUD 1997 Non-standard) MARIN F (MARI-Individual) A; HU200002986-A2; MX9909096-A1; allow small bubbles to form large IT1295976-B; HU220699-B1; EP979269-B1; bubbles. DE69715466-E; CA2253861-C; ES2181035- T3; MX214673-B Flow cytometer system for sorting WO200140765-A; EP1238261-A; XY INC (XYXY-Non-standard) US 1999 living sperm cells, e.g. bovine or WO200140765-A2; US6263745-B1;

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. equine sperm cells, for research, AU200132728-A; US2002005076-A1; clinic, or animal insemination industry, US6357307-B2; NO200202536-A; has single torsional orientation nozzle US2002129669-A1; GB2372466-A; below injection point. EP1238261-A2; KR2002063584-A; BR200016121-A; JP2003515337-W; CN1402831-A; HU200300587-A2; US6604435-B2; MX2002005488-A1; TW538243-A; US2004050186-A1; US6782768-B2 Genetic transformation system is for industrial yeasts or for laboratory lineages sensitive to L-canavanine CNPQ CONSELHO NACIONAL BR200014793-A BR 2000 and comprises yeast cloning vector DESENVOLVIMENTO (CNPQ-Non-standard) denominated as Y1pC, formed by double circular DNA film. Immobilisation of horseradish peroxidase VI for paper industry UNICAMP UNIV ESTADUAL CAMPINAS (UNIC- effluent clearing - consists of BR9702823-A BR 1997 Non-standard) decoloration by e.g. titanium oxide based enzymatic retention. WO200031016-A; EP1131278-A; Improved production of esters, useful WO200031016-A1; AU200016237-A; as industrial solvent and reagent, STALEY MFG CO A E (STAL) BR9916754-A; EP1131278-A1; US 1998 from an organic acid and an alcohol, JP2002530362-W; MX2001004603-A1; involves separation of time scales. US6664413-B1 EP686692-A; WO9527049-A; DE4411223-A; EP753058-A; DE4411223-A1; WO9527049- A1; AU9516175-A; JP7286194-A; Industrial laundry compsn. contg. FI9501520-A; EP686692-A2; AU9520731-A; specific alkaline protease from CA2146063-A; BR9501401-A; EP753058-A1; SOLVAY ENZYMES GMBH & CO KG (SOLV) Bacillus strains - stable under high FI9603829-A; EP686692-A3; BR9507237-A; AMORY A (AMOR-Individual) GENENCOR INT DE 1994 temp. and high pH conditions and in MX9604399-A1; JP10505741-W; NZ282821- GMBH (GENV) GENENCOR INT INC (GEMV) presence of other detergent A; US5880080-A; AU705385-B; AU710223- ingredients. B; US6165960-A; CN1148406-A; US6190904-B1; MX200584-B; EP686692-B1; DE59510341-G; EP753058-B1; DE59510914-G

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Inhibitors of cellulolytic, xylanolytic or WO9849278-A; EP996709-A; WO9849278- beta-glucanolytic enzymes - useful in LEUVEN RES & DEV (LEUV-Non-standard) KU A1; AU9877611-A; EP996709-A1; EP 1997 the brewing, baking and paper and LEUVEN RES & DEV (KULE-Non-standard) BR9809348-A; CN1254374-A; MX9910037- pulp industries. A1; JP2001523104-W; AU751631-B WO200009725-A; EP1104479-A; Large scale recovery of concentrated BIOSOURCE TECHNOLOGIES INC (BIOS-Non- WO200009725-A2; AU9953967-A; and active protein of interest from standard) LARGE SCALE BIOLOGY CORP EP1104479-A2; US6284875-B1; interstitial fluid of plant tissues, useful (LARG-Non-standard) TURPEN T H (TURP- KR2001072372-A; ZA200101100-A; in pharmaceutical and industrial Individual) GARGER S J (GARG-Individual) BR9912875-A; US6441147-B1; US 1998 applications comprises subjecting MCCULLOCH M J (MCCU-Individual) CAMERON JP2002522559-W; NZ510358-A; plant tissue and buffer solution to T I (CAME-Individual) SAMONEK-POTTER M L US2003073209-A1; AU759813-B; vacuum. (SAMO-Individual) HOLTZ R B (HOLT-Individual) US6617435-B2; MX2001001445-A1; US2004047923-A1; AU2003213542-A1 Method for concentrating trace genes WO200250268-A; WO200250268-A1; expressed even in presence of large SUNTORY LTD (SUNR) SUNTORY AU200222693-A; EP1344822-A1; amounts of (un)known genes, useful BIOMEDICAL RES LTD (SUNT-Non-standard) KR2003064846-A; BR200116199-A; JP 2000 in screening industrial enzymes, and NAKAZATO H (NAKA-Individual) US2004058360-A1; CN1473196-A; pharmaceutical and agrochemical JP2002552145-X leads from nature. Micro-industrial double distilled alcoholic drink fabricator, comprises carob syrup pressing and DA SILVA C G (DSIL-Individual) BR200206189-A BR 2002 fermentation means, with oak aging barrels and a copper still. Modified xylanase exhibiting WO200192487-A; WO200192487-A2; increased thermostability and NAT RES COUNCIL CANADA (CANA) SUNG W AU200167171-A; SE200203555-A; alkalophilicity useful for industrial US 2000 L (SUNG-Individual) US2003166236-A1; FI200202120-A; processing e.g. for pulp BR200111316-A manufacturing. WO9854335-A1; AU9874463-A; EP983369- Modifying galactomannans in guar A1; GB2342920-A; BR9809493-A; plants - used to provide compounds DANISCO AS (DANI-Non-standard) CN1264428-A; AU733483-B; GB2342920-B; GB 1997 with increased galactose-to-mannose KR2001012962-A; NZ500951-A; ratio, useful for the food industry. JP2002500515-W Must cooking tank used in the wine industry - includes a bricked spiral VARGAS E (VARG-Individual) BR9800028-A BR 1998 tube leading from the bottom firebox

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. of the tank. Mutant Chrysosporium strain WO200020555-A; EP1117808-A; comprising nucleic acid encoding WO200020555-A2; AU9962326-A; proteins, particularly industrially AARL INC (AARL-Non-standard) EMALFARB M BR9914278-A; EP1117808-A2; CN1330717- WOEP 1998 important enzymes such as A (EMAL-Individual) A; KR2001103596-A; MX2001003462-A1; cellulases, xylanases, pectinases, AU771539-B2 lipases and proteases. WO200007433-A; EP1100310-A; New Brassica plants and seeds WO200007433-A1; AU9953353-A; having elevated long chain EP1100310-A1; BR9912710-A; CN1315826- monounsaturated fatty acid content, CARGILL INC (CRGI) A; US2002092038-A1; US6414223-B1; US 1998 for industrial uses, e.g. engine JP2002528050-W; MX2001001224-A1; lubricants. US6649782-B2; US2004083503-A1; AU772286-B2 New construct for expressing genes WO9953080-A; EP1071798-A; FR2777292- in prokaryotes under control of the A1; WO9953080-A1; AU9931540-A; tryptophan operon, useful in FABRE MEDICAMENT SA PIERRE (FABR) BR9909643-A; EP1071798-A1; CN1303439- FR 1998 human/animal medicine, nutrition, A; MX2000010057-A1; JP2002511273-W; cosmetics, agriculture or chemical AU768595-B industry. WO200159128-A; EP1254238-A; New elongase gene extends 16, 18 WO200159128-A2; AU200139244-A; and 20 carbon fatty acids, useful to BASF AG (BADI) HEINZ E (HEIN-Individual) DE10023893-A1; DE10063387-A1; manipulate plants to produce ZANK T (ZANK-Individual) ZAHRINGER U CZ200202502-A3; NO200203757-A; DE 2000 polyunsaturated fatty acids for the (ZAHR-Individual) LERCHL J (LERC-Individual) EP1254238-A2; KR2002073580-A; foodstuffs, cosmetics and RENZ A (RENZ-Individual) BR200108198-A; CN1398300-A; pharmaceutical industries. HU200300081-A2; JP2003523746-W; MX2002007078-A1; US2004111763-A1 WO9931226-A; EP1042457-A; US6184020- NOVO-NORDISK AS (NOVO) NOVO NORDISK B2; WO9931226-A1; AU9913328-A; BIOTECH INC (NOVO) ASAHI CHEM IND CO New isolated aminopeptidase EP1042457-A1; BR9813608-A; US6184020- LTD (ASAH) NOVO NORDISK AS (NOVO) polypeptides used in, e.g. food B1; CN1282369-A; KR2001033182-A; DK 1998 JAPAN TOBACCO INC (NISB) NOVOZYMES industry. US6303360-B1; NZ505066-A; BIOTECH INC (NOVO) NOVOZYMES AS US2002177210-A1; AU755387-B; (NOVO) JP2003525573-W New method, useful in screening anti- KURITA WATER IND LTD (KURK) IIZUMI T WO200254865-A; WO200254865-A1; JP 2001 microbial agents for controlling slimes (IIZU-Individual) SUZUKI H (SUZU-Individual) JP2002205902-A; JP2003020598-A;

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. in papermaking industry or monitoring TASHIRO H (TASH-Individual) JP2003164281-A; EP1350431-A1; anti-microbial effect, comprises US2004132095-A1; BR200206375-A; microbial analysis step and anti- CN1496224-A microbial selection step. WO200077229-A; EP1185678-A; New nucleic acid molecules encoding AVENTIS CROPSCIENCE GMBH (AVET) ABEL DE19926771-A1; WO200077229-A2; R1-protein, useful for forming G (ABEL-Individual) LORZ H (LORZ-Individual) AU200058107-A; EP1185678-A2; transgenic plants producing starch DE 1999 LUTTICKE S (LUTT-Individual) SCHMIDT R BR200011499-A; US6462256-B1; with controllable properties, e.g. for (SCHM-Individual) JP2003502049-W; US2003077805-A1; use in the food industry. CN1402789-A New phenol oxidizing enzyme, also WO200121809-A; EP1214421-A; useful in the detergent, paper and US6168936-B1; WO200121809-A2; pulp, textile or food industries, AU200074767-A; NO200201386-A; especially in modifying the color GENENCOR INT INC (GEMV) EP1214421-A2; KR2002034195-A; US 1999 associated with dyes and colored CN1391611-A; JP2003528582-W; compounds, as well as in anti-dye MX2002003035-A1; BR200014229-A; transfer applications. NZ518004-A New plant desaturase polynucleotides WO200114538-A; EP1206558-A; useful for modifying fatty acid WO200114538-A2; AU200069134-A; compositions in plants or plant cells, CALGENE LLC (CALJ) FILLATTI J (FILL- BR200013607-A; EP1206558-A2; US 1999 and in transforming plants for Individual) FILLATTI J J (FILL-Individual) CN1378602-A; JP2003507062-W; producing vegetable oils for edible US2003079250-A1; US2003084480-A1; and industrial uses. US2003172399-A1; US2004098762-A1 New polyenoic fatty acid isomerase polypeptides and polynucleotides, WO200109296-A; EP1218497-A; useful for producing conjugated fatty MONSANTO CO (MONS) MONSANTO WO200109296-A1; AU200067494-A; acids from polyenoic fatty acyl US 1999 TECHNOLOGY LLC (MONS) BR200012873-A; EP1218497-A1; substrates, which are useful in MX2002001086-A1 industrial, animal feed and human nutritional applications. New protease derived from Aranicola KOREA RES INST BIOSCIENCE & WO200157222-A; EP1165807-A; proteolyticus, useful in industrial BIOTECHNOLOG (KORE-Non-standard) PARK H WO200157222-A1; AU200132151-A; applications e.g. detergents, (PARK-Individual) SON K (SONK-Individual) EP1165807-A1; KR2001077591-A; cosmetics, leather processing agents, KR 2000 PARK D (PARK-Individual) SHIN S (SHIN- BR200011186-A; KR2001112928-A; softening agents for food, feed Individual) OH H (OHHH-Individual) KIM M CN1345376-A; JP2003521926-W; additives and for treating digestive (KIMM-Individual) SHIN D (SHIN-Individual) US2004162417-A1 ailments.

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. New subtilase enzyme variants - WO9911769-A; EP1012251-A; WO9911769- having modifications in amino acid A1; AU9890617-A; EP1012251-A1; NOVO-NORDISK AS (NOVO) NOVO NORDISK positions 134 and/or 137, used in BR9811412-A; CN1272137-A; DK 1997 AS (NOVO) NOVOZYMES AS (NOVO) detergents or the leather or wool KR2001023468-A; MX2000001889-A1; industries. JP2001514846-W; US6558938-B1 New subtilase enzyme variants - WO9911770-A1; AU9890618-A; EP1007646- having modifications in amino acid NOVO-NORDISK AS (NOVO) NOVO NORDISK A1; BR9811396-A; CN1272881-A; positions 95, 97 and/or 98, used in DK 1997 AS (NOVO) NOVOZYMES AS (NOVO) KR2001023448-A; MX2000001890-A1; detergents or the leather or wool JP2001514847-W industries. Novel endo-beta-1,4-glucanase useful WO200073428-A; EP1185631-A; in various industrial applications WO200073428-A1; AU200047449-A; NOVO NORDISK AS (NOVO) NOVOZYMES AS including degradation of cellulose- EP1185631-A1; BR200010998-A; DK 1999 (NOVO) containing biomass, detergent, paper, KR2002012249-A; CN1353751-A; pulp and textile industries. JP2003501021-W; MX2001012179-A1 Novel isolated and purified bovine or WO200134647-A; EP1232182-A; porcine collagens and gelatins useful FIBROGEN INC (FIBR-Non-standard) BELL M P WO200134647-A2; AU200115918-A; in medical, pharmaceutical, food and (BELL-Individual) NEFF T B (NEFF-Individual) EP1232182-A2; BR200015507-A; US 2000 cosmetic industries, as vaccine, and POLAREK J W (POLA-Individual) SEELEY T W JP2003513659-W; CN1420892-A; for treating autoimmune disorders, (SEEL-Individual) US2004005663-A1; US2004018592-A1 infections and cancer. Novel isolated protease polypeptide WO200268623-A; WO200268623-A2; useful in laboratory, clinical, EP1377664-A2; KR2003080229-A; pharmaceutical, chemical, diagnostic, DSM NV (STAM) DSM IP ASSETS BV (STAM) EP 2001 AU2002308306-A1; CN1492924-A; personal care and industrial BR200207517-A applications. Novel nucleic acid isolated from Lesquerella fendleri encodes a condensing enzyme involved in fatty UNIV BRITISH COLUMBIA (UYBR-Non-standard) EP1285073-A; WO200190364-A2; acid synthesis and is useful to KUNST L (KUNS-Individual) SMITH M A (SMIT- AU200174408-A; EP1285073-A2; US 2000 produce plants which synthesize Individual) MOON H (MOON-Individual) BR200111115-A; US2004049806-A1 hydroxylated very long chain fatty acids for industrial applications. Novel plasmid derived from EP979875-A; EP979875-A1; JP2000050869- Gluconobacter bacteria, useful for AJINOMOTO CO INC (AJIN) AJINOMOTO KK A; CN1256308-A; US6127174-A; JP 1998 genetic manipulation of the bacteria to (AJIN) BR9903646-A; KR2000017225-A produce industrially superior strains,

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. which produce D-xylulose and xylitol. Novel polynucleotides encoding WO200039305-A; EP1147198-A; Corynebacterium glutamicum SINSKEY A J (SINS-Individual) LESSARD P A WO200039305-A1; AU9922033-A; pyruvate carboxylase useful for (LESS-Individual) WILLIS L B (WILL-Individual) BR9816106-A; EP1147198-A1; CN1336958- WOUS 1998 industrial fermentation processes MASSACHUSETTS INST TECHNOLOGY (MASI) A; KR2001112232-A; JP2003503006-W; comprises a specific nucleotide MX2001006290-A1 sequence. Novel recombinant nucleic acid encoding proteinaceous molecule, EP1379663-A; WO200264764-A; useful for producing flavor, fragrance EP1231273-A1; WO200264764-A2; and/or biocontrol agent which is PLANT RES INT BV (PLAN-Non-standard) EP 2001 EP1379663-A2; BR200207164-A; useful as food additive in processed AU2002233824-A1; US2004161819-A1 food industry and as antimicrobial agent. WO9949050-A; EP1064387-A; WO9949050- A3; WO9949050-A2; AU9931849-A; Nucleic acid fragments useful in the EP1064387-A2; NO200004680-A; production of industrial agents for eg. DU PONT DE NEMOURS & CO E I (DUPO) KR2001042015-A; MX2000009177-A1; US 1998 lubricants or cosmetics. HU200102912-A2; BR9908381-A; JP2002528048-W; AU763296-B; NZ505988- A Obtaining cellulosic wet sheet used e.g. as thickening agent in food and beverage industry, comprises heating LEVY N L F (LEVY-Individual) FERREIRA LEVY WO2004050986-A1; BR200205499-A; solution containing glucose mass and BR 2002 N L (LEVY-Individual) AU2003283089-A1 yeast extract in water, adding inoculum Acetobacter xylinum, and fermenting in covered trays. Process for degradation or WO200056867-A; EP1163328-A; modification of fibers or fabric in WO200056867-A1; AU200034183-A; laundering and textile processing NOVO NORDISK AS (NOVO) NOVOZYMES AS US6296671-B1; BR200009184-A; US 1999 industries, containing plant material, (NOVO) EP1163328-A1; KR2001109318-A; involves treating fibers or fabric with CN1344316-A; JP2003524708-W; polymethyl glacturonase enzyme. MX2001009492-A1 Producing cells expressing a protein BAYER CORP (FARB) CHO M (CHOM- WO200034505-A; WO200034505-A1; having factor VIII procoagulant activity Individual) CHAN S (CHAN-Individual) KELSEY AU200021701-A; NO200102718-A; US 1998 especially, human factor VIII in an W (KELS-Individual) YEE H (YEEH-Individual) EP1137797-A1; BR9916069-A;

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. industrial scale, involves expressing a CZ200102024-A3; SK200100792-A3; vector comprising a sequence coding US6358703-B1; US2002102730-A1; for factor VIII in human cells. HU200200558-A2; KR2002013481-A; US2002115152-A1; MX2001005667-A1; JP2002531137-W; NZ512234-A; AU761801- B UNIV RIO DE JANEIRO (UYRI-Non-standard) DE FIGUEIREDO J G (DFIG-Individual) UNIV Producing enzymatic preparation for FEDERAL RIO DE JANEIRO UFRJ (UYRI-Non- WO200233055-A; EP1337628-A; treating industrial and domestic standard) CAMMAROTA M C (CAMM-Individual) WO200233055-A1; BR200007101-A; effluents of high fat, protein, GUIMARAES FREIRE D M (FREI-Individual) AU200193524-A; EP1337628-A1; BR 2000 carbohydrate content, involves using LIPPEL SANT ANNA G (ANNA-Individual) US2004055953-A1; JP2004510451-W; Penicillium restrictum in solid-state RUSSO C (RUSS-Individual) DIAS DE CN1478144-A fermentation process. CARVALHO FREIRE D (FREI-Individual) DOS REIS CASTILHO L (CAST-Individual) Producing full mutant polyploidy WO9815621-A; EP946716-A; WO9815621- plants, e.g. wheat with altered starch - A1; AU9748959-A; EP946716-A1; by treating polyploid plants with non- BR9712502-A; CN1239509-A; US6143963- EXSEED GENETICS LLC (EXSE-Non-standard) US 1997 full mutant allele with mutagen, useful A; JP2001501828-W; NZ334873-A; to produce wheat with low amylose MX9903298-A1; US6361935-B1; content for food industry. AU200143916-A Producing lactic acid bacteria defective in pyruvate formate-lyase WO9807843-A; WO9807843-A1; production - comprises selection by CHR HANSEN AS (CHRH-Non-standard) AU9738475-A; EP928333-A1; BR9711341-A; US 1996 metabolic engineering, useful in, e.g. NILSSON D (NILS-Individual) AU723153-B; US6645754-B1; food industry as starter cultures for US2004086955-A1 wine manufacture. WO9967398-A; EP1090129-A; WO9967398- A2; AU9950837-A; EP1090129-A2; BR9911549-A; KR2001043988-A; Producing phytase in yeast useful for CORNELL RES FOUND INC (CORR) CN1313898-A; HU200102800-A2; US 1998 the food and feed industries. MX2000012794-A1; CZ200004805-A3; JP2002518052-W; US2002102692-A1; US6451572-B1; AU772071-B2 Production of active transglutaminase WO200040706-A; EP1142990-A; from denatured enzyme by two-stage AJINOMOTO CO INC (AJIN) WO200040706-A1; AU200017991-A; JP 1998 refolding process for industrial EP1142990-A1; BR9916627-A; CN1334867-

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. production of active enzyme for use in A; JP2000592404-X; US2002090675-A1; food production. AU762951-B Production of enzyme granules with WO200183727-A; WO200183727-A2; improved characteristics, useful in DSM NV (STAM) BARENDSE R C M (BARE- AU200170500-A; EP1278595-A2; food (e.g. baked products, dairy Individual) MEESTERS G M H (MEES-Individual) BR200110466-A; US2003124224-A1; EP 2000 products, beverages) and feed HAPPEL A J M (HAPP-Individual) CZ200203626-A3; CN1427740-A; industries, using a continuous fluid JP2003531608-W bed method. WO200159143-A; EP1259632-A; Production of flavonoid DE10006147-A1; WO200159143-A1; monoglycosides, used e.g. in food MERCK PATENT GMBH (MERE) OHREM H L AU200131726-A; EP1259632-A1; and cosmetics industry, uses enzyme (OHRE-Individual) SCHWAMMLE A (SCHW- DE 2000 BR200108273-A; KR2003013371-A; immobilized on carrier for enzymatic Individual) CN1416470-A; JP2003522532-W; hydrolysis of rutinosides. US2003157653-A1 Purifying waste water, e.g. seep WO200104060-A; EP1204608-A; water, grey water, black water, WO200104060-A2; AU200061626-A; industrial waste water and/or waste JUVEGROUP OY (JUVE-Non-standard) FI106042-B1; BR200012422-A; EP1204608- water from laundries, using bacterial CLEWER LTD OY (CLEW-Non-standard) FI 1999 A2; HU200202345-A2; CZ200200041-A3; strains Bacillus Sp. DT-1, CLEWER OY (CLEW-Non-standard) JP2003504185-W; CN1420848-A; Pseudomonas azelaica DT-2 and/or US6780317-B1 Rhizobium sp. DT-5. Recombinant filamentous fungus produced by gene conversion - has GIST-BROCADES BV (KONN) DSM NV (STAM) WO9846772-A; EP979294-A; WO9846772- DNA integrated into two or more SELTEN G C M (SELT-Individual) SWINKELS B A2; AU9876422-A; EP979294-A2; EP 1997 mostly homologous DNA domains of W (SWIN-Individual) BOVENBERG R A L (BOVE- BR9808859-A; CN1257546-A; MX9909238- its chromosomes, used in the Individual) A1; JP2001518798-W; US6432672-B1 fermentation industry. Recovering valuable component from EP838256-A; EP838256-A2; AU9741028-A; crude liquid in e.g. pharmaceutical, ZA9709288-A; JP10211423-A; CN1194178- fermentation, sugar or chemical NITTETSU CHEM ENG LTD (NITA) AJINOMOTO A; TW343158-A; SK9701403-A3; industries - by mixing liquid with CO INC (AJIN) NITTETSU CHEM MACH KK KR98032908-A; SG65691-A1; BR9705089- JP 1997 washing liquid in successive stages (NITA) AJINOMOTO KK (AJIN) NITTETSU A; MX9708029-A1; US6039879-A; and from each stage recovering KAKOKI KK (NITA) AU725608-B; SK282079-B6; MX207174-B; component via membrane as EP838256-B1; DE69727028-E; permeate. PH1199758236-B1 Sample arrays for measuring the TRANSFORM PHARM INC (TRAN-Non- WO200109391-A; EP1204766-A; US 2000 interaction between components to standard) WO200109391-A1; AU200065023-A;

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. prepare new compositions for EP1204766-A1; SK200200111-A3; pharmaceutical, industrial, functional CZ200200334-A3; BR200012767-A; or agrochemical use have a KR2002034168-A; JP2003509657-W; component in common and at least MX2002000890-A1; ZA200200503-A one additional component. Secretion production of foreign AJINOMOTO CO INC (AJIN) AJINOMOTO KK WO200281694-A; WO200281694-A1; proteins by culturing transformant (AJIN) KIKUCHI Y (KIKU-Individual) DATE M EP1375664-A1; BR200208136-A; coryneform bacteria, applicable in (DATE-Individual) UMEZAWA Y (UMEZ- KR2003087042-A; AU2002242986-A1; JP 2001 producing e.g. industrially-useful Individual) YOKOYAMA K (YOKO-Individual) US2004126847-A1; JP2002580057-X; transglutaminase and human HEIMA H (HEIM-Individual) MATSUI H (MATS- CN1500145-A epithelial growth factor. Individual) WO9811205-A; EP929682-A; WO9811205- Sequences useful for modification of GENESIS RES & DEV CORP LTD (GENE-Non- A2; AU9744036-A; US5850020-A; plant lignin content or structure - from standard) FLETCHER CHALLENGE FORESTS EP929682-A2; BR9711745-A; NZ334565-A; Eucalyptus grandis (eucalyptus) and LTD (FLET-Non-standard) GENESIS RES & DEV JP2001500378-W; US6204434-B1; US 1996 Pinus radiata (pine) are associated (GENE-Non-standard) RUBICON FORESTS MX9902262-A1; AU733388-B; ZA9710451-A; with lignin biosynthesis pathway, HOLDINGS LTD (RUBI-Non-standard) ZA9810574-A; AU200157975-A; AU756359- useful e.g. in paper industry. B; AU2003203517-A1 Sprinkler type rotary reactor for semi- solid culture of microorganisms (e.g. UNIV FUNDACAO CAXIAS DO SUL (UYCA-Non- in pharmaceutical production) is BR200201315-A BR 2002 standard) easily scaleable from laboratory to pilot to industrial scale. Storage-stable enzyme composition in tablet form comprises enzymes, WO200216540-A; EP1315791-A; tabletting auxiliaries, disintegrating CLARIANT FINANCE BVI LTD (CLRN) WO200216540-A1; EP1315791-A1; systems, but no detergent CLARIANT INT LTD (CLRN) SIGMUND H (SIGM- BR200113319-A; US2003171238-A1; GB 2000 components, useful for treatment of Individual) CN1447853-A; JP2004507578-W; textile materials and in paper and pulp MX2003001527-A1 industry. Supplying starter culture for food industry comprises using subsets of WO200170935-A; EP1268745-A; stock inoculum material comprising CHR HANSEN AS (CHRH-Non-standard) WO200170935-A2; US2001049132-A1; concentrate of cells to be KRINGELUM B (KRIN-Individual) KRINGEL M AU200144083-A; NO200204503-A; US 2000 propagated for direct inoculation of (KRIN-Individual) NIELSEN K S (NIEL-Individual) BR200109497-A; EP1268745-A2; cultivation medium to obtain starter JP2003527853-W; NZ521814-A culture.

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Termamyl-like alpha-amylase variants WO9741213-A; EP904360-A; WO9741213- with improved properties - e.g. A1; AU9726928-A; EP904360-A1; increased stability at low pH and low NOVO-NORDISK AS (NOVO) NOVO NORDISK CN1217020-A; BR9708887-A; DK 1996 calcium, useful as detergent additives AS (NOVO) NOVOZYMES AS (NOVO) JP2000508914-W; US6143708-A; and in industrial starch processing US6436888-B1; US2003171236-A1; e.g. liquefaction. US6642044-B2; US2004048351-A1 Transforming trees to modify their fiber characteristics, useful in the ADVANCED TECHNOLOGIES CAMBRIDGE WO200012715-A; EP1108030-A; forestry industry, comprises (ADTE-Non-standard) ADVANCED WO200012715-A1; AU9954361-A; GB 1998 incorporating a chimeric gene TECHNOLOGIES CAMBRIDGE LTD (ADTE-Non- BR9913486-A; EP1108030-A1; CN1325448- encoding expansins into the plant standard) A; JP2002523095-W; NZ509810-A genome.

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Em relação aos termos referentes ao tema bioindústria foram localizadas patentes depositadas no Brasil em apenas um deles (designing). Na tabela, abaixo, são listados os títulos das patentes com seus respectivos depositantes, números das patentes, país de prioridade e ano de prioridade.

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a. TERMO: DESIGNING

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. EP1290014-A; WO200185769-A2; AU200159705- New representation of the three-dimensional AMERICAN HOME A; NO200205378-A; BR200110742-A; solution structure of an RGS (regulator of G- PROD CORP EP1290014-A2; KR2003004397-A; protein signaling), useful for identifying, selecting US 2000 (AMHP) WYETH US2003186413-A1; JP2003532741-W; or designing agonists and antagonists of RGS4 (AMHP) CN1440421-A; HU200302548-A2; activity. MX2002011033-A1; ZA200210012-A Designing and constructing a variant of AJINOMOTO CO WO200214518-A; WO200214518-A1; Streptoverticillium mobaraense-originated INC (AJIN) AU200178739-A; JP2002253272-A; EP1310560- transglutaminase (MTG), for use in food JP 2000 AJINOMOTO KK A1; KR2003027037-A; US2004002144-A1; processing, comprises estimating the binding site (AJIN) BR200113304-A; CN1469929-A of MTG based on its stereo-structure. New method of determining a patient's WO9854359-A; EP983385-A; WO9854359-A1; susceptibility to inflammatory disorders - by ZA9804490-A; AU9875398-A; NO9905803-A; detecting the presence of an IL-1 (44112332) DUFF G (DUFF- EP983385-A1; BR9809183-A; CN1278868-A; GB 1997 haplotype, useful in designing treatment Individual) US6268142-B1; JP2002500513-W; AU755107-B; strategies that modulate the activity of proteins US2002146700-A1; US6706478-B2; produced by the IL-1 gene cluster. US2004152124-A1; AU2003200791-A1

173

4. TEMA: BIORREMEDIAÇÃO

A seguir são listados os títulos das patentes depositadas no Brasil, sobre o tema biorremediação, com seus respectivos títulos, depositantes, números da patente, país de prioridade e ano de prioridade.

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Coated metal peroxide, used for bioremediation of WO200206155-A; soil, has siliconate, SOLVAY INTEROX EP1174389-A; EP1174389- hydrido-polysiloxane, GMBH (SOLV) A1; DE10035287-A1; siloxane, silicone resin DOETSCH W WO200206155-A1; DE 2000 emulsion, silane/siloxane (DOET-Individual) US2002051744-A1; emulsion, WASEM G (WASE- AU200177535-A; siloxane/siloxane mixture, Individual) US6547490-B2; silicone microemulsion or BR200112507-A silicate ester coating. GLAZE B S (GLAZ- WO9425628-A; EP695369-A; Individual) WO9425628-A1; AU9466283- WARNER K R A; EP695369-A1; Method for accelerated (WARN-Individual) BR9405960-A; CZ9502597- bioremediation - esp of HORN T D (HORN- A3; JP8508198-W; material contaminated Individual) HORN US5593888-A; NZ265501-A; US 1994 with hydrocarbons, heavy R D (HORN- AU697852-B; CZ289901-B6; metals, nuclear fission Individual) H & H CA2372565-A1; CA2159619- products, explosives, etc. ECO SYSTEMS C; EP695369-B1; INC (HHEC-Non- DE69431245-E; CA2372565- standard) C; MX219832-B

5. TEMA: CERTIFICAÇÃO DE QUALIDADE BIOLÓGICA

Não foram localizadas patentes depositadas no Brasil com o tema certificação de qualidade biológica. Em relação aos termos referentes ao tema foram localizadas patentes depositadas no Brasil em apenas um deles (coleções certificadas). Na tabela, abaixo, são listados os títulos das patentes com seus respectivos depositantes, números das patentes, país de prioridade e ano de prioridade.

174 a. TERMO: COLEÇÕES CERTIFICADAS

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Identifying a region CANADA DEPT AGRIC & WO200212551-A; within a genome of AGRI-FOOD CANADA (MIAC) EP1366184-A; organism mediating DNA LANDMARKS INC WO200212551-A2; gene expression, (DNAL-Non-standard) AU200176208-A; useful for determining CANADA MIN AGRICULTURE CZ200300146-A3; mutation, comprises (MIAC) CASTONGUAY Y US2003180761-A1; US 2000 crossing 2 (CAST-Individual) HU200302058-A2; organisms, extracting O'DONOUGHUE L S (ODON- EP1366184-A2; RNA, quantifying Individual) LABERGE S BR200112707-A; gene expression and (LABE-Individual) MONROY A CN1474875-A; identifying F (MONR-Individual) VEZINA L JP2004512828-W quantitative trait loci. P (VEZI-Individual)

6. TEMA: FERTILIDADE E REPRODUÇÃO ANIMAL

Não foram localizadas patentes depositadas no Brasil com o tema fertilidade e reprodução animal. Em relação aos termos referentes ao tema foram localizadas patentes depositadas no Brasil em apenas um deles (Clonagem). Na tabela, abaixo, são listados os títulos das patentes com seus respectivos depositantes, números das patentes, país de prioridade e ano de prioridade. a. TERMO: CLONAGEM

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. WO200124624-A; EP1215960-A; In vitro reconstitution of FR2799099-A1; mammalian embryos, WO200124624-A2; INRA INST NAT RECH useful e.g. for producing AU200076690-A; AGRONOMIQUE (INRG) transgenic animals or EP1215960-A2; FR 1999 INST NAT RECH cloning, including BR200014451-A; AGRONOMIQUE (INRG) proteolysis and swelling of CN1377226-A; donor diploid nucleus. ZA200202500-A; AU775410-B2; NZ518377-A Bioassay for determining amount of active myostatin in animal, by amplifying WO2003006686-A; and cloning promoter, WO2003006686- AGRESEARCH LTD (AGRE- transfecting vector, A1; NZ512869-A; Non-standard) OVITA LTD NZ 2001 selecting, incubating, and EP1404866-A1; (OVIT-Non-standard) washing myoblasts, BR200211095-A; preparing protein extracts, AU2002328046-A1 and performing gene assay.

175

NÚMERO DA PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE PATENTE PRIOR. PRIOR. WO9937143-A; EP1049372-A; WO9937143-A2; AU9922377-A; Cloning animals by UNIV HAWAII (UYHA-Non- BR9907193-A; inserting nucleus from adult standard) WAKAYAMA T EP1049372-A2; somatic cells into (WAKA-Individual) KR2001040370-A; US 1998 enucleated oocyte, YANAGIMACHI R (YANA- CN1306390-A; particularly for producing Individual) US6331659-B1; transgenic animals. JP2002500864-W; US2002019993-A1; NZ505728-A; AU765170-B

7. TEMA: INTEGRAÇÃO: ALIMENTAÇÃO, NUTRIÇÃO E SAÚDE

Apresenta-se a seguir os títulos das patentes depositadas no Brasil, sobre o tema Integração: Alimentação, Nutrição e Saúde, com seus respectivos títulos, depositantes, números das patentes, país de prioridade e ano de prioridade.

PAÍS NÚMERO DA ANO TÍTULO DA PATENTE DEPOSITANTE PRIO PATENTE PRIOR. R. NESTEC LTD (NEST) NESTLE PURINA PETCARE CO (NEST- Manufacturing method for pet food Non-standard) SINGH B R US6493641-B1; that is customized to health and (SING-Individual) WO2002102172-A1; nutrition requirements of e.g. an KALISHMAN D S (KALI- US2003004655-A1; individual dog, involves tailoring food Individual) NIELSEN M EP1401291-A1; US 2001 in response to biological analysis of (NIEL-Individual) BR200210918-A; pet sample, e.g. saliva, and pet BADGER B W (BADG- AU2002315123-A1; profile provided by owner. Individual) MARTINEAU B JP2004529656-W (MART-Individual) CARVALHO R (CARV- Individual) EP943245-A; EP943245-A1; AU9873072-A; JP11292898-A; CN1228927-A; CA2240795-A1; KR99076483-A; US6132795-A; New vegetable protein composition, PROTEIN MX9805417-A1; useful in foods for improving health TECHNOLOGIES INT INC JP3118451-B2; US 1998 and nutritional benefits. (PROT-Non-standard) BR9815832-A; AU732423-B; CA2240795-C; TW491688-A; EP943245-B1; DE69908219-E; KR375981-B; MX212317-B; ES2199523-T3

176

PAÍS NÚMERO DA ANO TÍTULO DA PATENTE DEPOSITANTE PRIO PATENTE PRIOR. R. Table food and drink container temperature display gauge SCUDELER J (SCUD- BR9904515-A BR 1999 increases nutritive and health Individual) value of meals.

Em relação aos termos referentes ao tema Integração: Alimentação, Nutrição e Saúde foram localizadas patentes depositadas no Brasil em dois deles (Nutracêuticos e Produção de Vacina) Nas tabelas, abaixo, são listados os títulos das patentes com seus respectivos depositantes, números das patentes, país de prioridade e ano de prioridade.

177 a. NUTRACÊUTICOS (ALIMENTOS FUNCIONAIS)

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO200138396-A; WO200138396-A1; A collagen product extracted from the skin of cold NEW ZEALAND INST CROP & FOOD RES AU200119027-A; BR200016032-A; water fish in paste form, useful as a fining agent LTD (NZCR-Non-standard) MACDONALD EP1233985-A1; NZ501386-A; NZ 1999 for the brewing and wine industries, or as a G A (MACD-Individual) HOFMAN K (HOFM- US2003004315-A1; JP2003514919-W; foodstuff, medicament, nutraceutical or cosmetic. Individual) CN1402736-A; NZ519878-A CA2338525-A1; JP2001346548-A; Functional food ingredient as e.g. meat thickener PROTEIN TECHNOLOGIES INT INC JP2001346550-A; BR200100398-A; and emulsifier, comprises unrefined plant protein (PROT-Non-standard) SOLAE LLC (SOLA- US6465037-B1; MX2001002250-A1; US 2000 material. Non-standard) KR411589-B; KR431977-B; MX2001002251-A1 EP1129626-A; EP1129626-A2; AU200069671-A; AU200124777-A; AU200124778-A; ZA200100536-A; CA2310296-A1; BR200004240-A; CN1310957-A; ZA200101638-A; ZA200101640-A; JP2001346544-A; BR200102199-A; BR200102288-A; Functional food ingredient used in food CN1318315-A; HU200100922-A2; applications, comprises flaked soy material PROTEIN TECHNOLOGIES INT INC HU200100923-A2; KR2001085211-A; having soy protein which is partially denatured (PROT-Non-standard) SOLAE LLC (SOLA- US 2000 CN1323547-A; US6355295-B1; such that, when combined with water, has Non-standard) HU200005045-A2; ES2165827-T1; specified gel strength and gel weight. NZ510199-A; NZ510203-A; NZ509563- A; AU755396-B; NZ520357-A; NZ520358-A; NZ520359-A; NZ520360- A; KR372936-B; MX2000008003-A1; RU2218815-C2; RU2225695-C2; AU771079-B2; RU2238664-C2 Infusion packet for preparing nutraceutical WO200170591-A; EP1268305-A; beverage, includes support member which acts WO200170591-A1; US2002012689-A1; AU200147679-A; BR200109498-A; as handle for proper placement of packet in liquid STILLMAN S J (STIL-Individual) US 2000 EP1268305-A1; CN1422230-A; and connects at least two packets into functional JP2003528011-W; unit. ZA200206909-A; MX2002009231-A1

178

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. SCHOTT GLAS (ZEIS) US BIOMATERIALS WO200172262-A; WO200172262-A2; Compositions comprising bioactive glass, useful CORP (USBI-Non-standard) LEE S (LEES- AU200149510-A; US2002086039-A1; as cosmetics, cleaning agents, personal care Individual) KESSLER S (KESS-Individual) EP1272144-A2; KR2003019333-A; US 2000 products, biocidal agents, functional foods and FORBERICH O (FORB-Individual) JP2004500404-W; CN1455661-A; nutritional supplements. BUCHWAR C (BUCH-Individual) BR200109603-A GREENSPAN D C (GREE-Individual) Sugarcane juice spread, e.g. ginger and cumin flavored sugarcane juice spread, comprises concentrated sugarcane juice, xanthan, COUNCIL SCI & IND RES (COUL) CA2378890-A1; BR200200949-A CA 2002 carrageenan, food preservative, gelling agent and nutraceutical. WO9963841-A; EP1082026-A; Composition suitable for incorporation into e.g. WO9963841-A1; AU9940275-A; FORBES MEDI-TECH INC (FORB-Non- foods, beverages, pharmaceuticals and EP1082026-A1; BR9910950-A; US 1998 standard) nutraceuticals. JP2002517418-W; NZ508645-A; AU771960-B2

179 b. PRODUÇÃO DE VACINAS

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Producing viruses e.g. reovirus EP1370643-A; WO200274940-A; from cell cultures for vaccine WO200274940-A1; US2002168764-A1; production, involves extracting ONCOLYTICS BIOTECH INC EP1370643-A1; BR200207527-A; viruses from cell culture infected by US 2001 (ONCO-Non-standard) AU2002242520-A1; JP2004520841-W; the virus by adding a detergent to US6808916-B2; MX2003007535-A1; the culture and incubating, and ZA200306228-A collecting the virus. EP770677-A; EP770677-A2; CA2185406-A; CA2185407-A; JP9173059-A; EP770677-A3; Sustainable chicken cell line AU9723568-A; JP10004956-A; MX9605139- infected with Marek's disease virus UNIV MICHIGAN STATE (UNMS) A1; BR9605244-A; BR9703544-A; US 1996 - for vaccine production against US5827738-A; US5833980-A; KR98002250-A; Marek's disease in poultry. AU697814-B; US5866117-A; US5874303-A; MX9702769-A1; CN1170760-A Live attenuated porcine EP835930-A; EP835930-A1; JP10117773-A; reproductive respiratory syndrome CA2217882-A; BR9705009-A; KR98032672- virus - which is non-infectious to AKZO NOBEL NV (ALKU) A; US5925359-A; MX9707780-A1; EP835930- EP 1996 macrophages, useful for vaccine B1; DE69704011-E; MX195397-B; production. ES2157522-T3; PH1199758127-B1 WO9736914-A; EP900232-A; WO9736914- A1; AU9725873-A; EP900232-A1; High molecular weight proteins of BARENKAMP S J (BARE-Individual) CN1222914-A; US5977336-A; non-typeable Haemophilus UNIV WASHINGTON (UNIW) UNIV NZ332322-A; AU723159-B; US 1996 influenzae - useful for vaccine ST LOUIS (UYSL-Non-standard) MX9808107-A1; JP2001503602-W; production. BR9708413-A; US2002164354-A1; RU2206610-C2 Iron-regulated promoter useful in site-specific chromosomal COMMONWEALTH SCI & IND RES WO9810064-A; EP964924-A; integration - especially of foreign ORG (CSIR) AUSTRALIAN WOOL WO9810064-A1; AU9736892-A; ZA9707109- antigen genes into AU 1997 RES & PROMOTION ORG (AUWO- A; EP964924-A1; NZ334649-A; chromosomes of attenuated Non-standard) BR9711692-A; AU737981-B Salmonella typhimurium strains for live vaccine production.

180

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. EP873752-A; EP873752-A2; NZ330251-A; Microcapsules containing bovine AU9863511-A; JP10316586-A; CN1196931-A; PFIZER INC (PFIZ) UNIV TEMPLE herpes virus immunogen - in CA2229430-A; ZA9803327-A; AU713639-B; (UTEM) CHILDRENS HOSPITAL US 1997 spermine-alginate membrane, BR9801435-A; MX9803277-A1; US6270800- PHILADELPHIA (CHIL-Non-standard) useful for vaccine production. B1; EP873752-B1; DE69822542-E; ES2216242-T3 WO9947648-A; EP1062324-A; FR2775983- PASTEUR MERIEUX SERUMS & A1; WO9947648-A2; AU9927352-A; Albumin-free medium for VACCINS SA (INMR) MERIAL SAS EP1062324-A2; BR9908744-A; propagating and multiplying viruses (MERI-Non-standard) AVENTIS CZ200003327-A3; HU200101081-A2; FR 1998 in cultured cells, especially for PASTEUR (AVET) AVENTIS SK200001288-A3; CN1301297-A; vaccine production. PASTEUR SA (AVET) MERIAL KR2001072556-A; JP2002506636-W; (MERI-Non-standard) NZ506872-A; AU752577-B; MX2000008511- A1

181

8. TEMA: PROGRAMAS DE DESCOBERTA

Em relação aos termos referentes ao tema foram localizadas patentes depositadas no Brasil em quatro deles (Clonagem, Stem Cells, Engenharia Genética e Nanobiotecnologia). Na tabela, abaixo, são listados os títulos das patentes com seus respectivos resumos, números das patentes, país de prioridade e ano de prioridade.

182 a. CLONAGEM

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Equine infectious anaemia virus water VALLEE SA (VALL-Non-standard) EMBRAPA- soluble fusion protein P26 consists of EMPRESA BRASILEIRA PESQUISAS AGR amino acids and the gag of the virus BR200004549-A BR 2000 (EMBR-Non-standard) UNIV RIO DE JANEIRO for cloning of the isolated DNA (UYRI-Non-standard) fragment. WO200104288-A; EP1204740-A; WO200104288-A1; AU200066911-A; DNA cloning and subcloning using US6355412-B1; EP1204740-A1; bacterial recombinase-mediated EURO MOLECULAR BIOLOGY LAB (EUMO- BR200012283-A; homologous recombination for US 1999 Non-standard) KR2002033726-A; HU200201963-A2; detecting an infection or genetic CN1373803-A; JP2003504053-W; condition in a patient. ZA200200152-A; NZ516722-A; MX2002000233-A1 Cloning pigs using differentiated cell as nucleus donor, useful for producing WO200119181-A; WO200119181-A1; cells and tissues for human UNIV MASSACHUSETTS (UYMA-Non- AU200073725-A; BR200013959-A; transplantation, comprises inserting a US 1999 standard) EP1241931-A1; CN1377225-A; differentiated pig cell into a pig oocyte JP2003509031-W; MX2002002653-A1 and activating the resultant nuclear transfer unit. WO200124624-A; EP1215960-A; In vitro reconstitution of mammalian FR2799099-A1; WO200124624-A2; embryos, useful e.g. for producing INRA INST NAT RECH AGRONOMIQUE AU200076690-A; EP1215960-A2; transgenic animals or cloning, including (INRG) INST NAT RECH AGRONOMIQUE FR 1999 BR200014451-A; CN1377226-A; proteolysis and swelling of donor (INRG) ZA200202500-A; AU775410-B2; NZ518377- diploid nucleus. A Genetic transformation system is for industrial yeasts or for laboratory lineages sensitive to CNPQ CONSELHO NACIONAL L-canavanine and comprises yeast BR200014793-A BR 2000 DESENVOLVIMENTO (CNPQ-Non-standard) cloning vector denominated as Y1pC, formed by double circular DNA film.

183

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO200139797-A; EP1234024-A; WO200139797- A2; AU200130051-A; BR200016145-A; Preparing DNA for preparing viral RNA or ES2170622-A1; NO200202419-A; EP1234024- virions, involves cloning DNA having full A2; SK200200761-A3; CZ200201882-A3; length copy of genomic RNA of RNA virus, CONSEJO SUPERIOR INVESTIGACIONES KR2002060251-A; HU200203305-A2; ES 1999 or its fragment encoding RNA dependent CIENTIF (CNSJ) SANCHEZ L E (SANC-Individual) ZA200203560-A; JP2003515335-W; CN1402780- RNA polymerase into bacterial artificial A; US2003148325-A1; NZ518990-A; chromosome. US2004086846-A1; EP1234024-B1; ES2170622-B1; DE60010921-E; EP1437400-A2; ES2218276-T3 Identifying antigenic polypeptides UNIV SHEFFIELD (UYSH-Non-standard) WO200198499-A; EP1292681-A; WO200198499- expressed by pathogenic organisms e.g., BIOSYNEXUS INC (BIOS-Non-standard) FOSTER S A1; AU200174248-A; NO200205838-A; Staphylococcus aureus during infection, by (FOST-Individual) MCDOWELL P (MCDO-Individual) EP1292681-A1; BR200111823-A; GB 2000 SEREX (serological identification of BRUMMELL K (BRUM-Individual) CLARKE S US2003186275-A1; CN1437653-A; antigens by recombinant expression (CLAR-Individual) JP2004500883-W cloning) techniques. EP1327000-A; Transposon-mediated multiplex sequencing AVENTIS PHARM INC (AVET) AUGUST P R WO200204674-A2; of DNA comprises cloning multiple DNA (AUGU-Individual) KEAGLE P J (KEAG-Individual) AU200173185-A; NO200206206-A; EP1327000- target sequences into a vector, and LONG H (LONG-Individual) MONTMAYEUR A W A2; KR2003021244-A; BR200112261-A; US 2000 randomly inserting selectable transposons (MONT-Individual) CALL K (CALL-Individual) US2003219779-A1; JP2004502467-W; with sequencing primers into the DNA DRAPER M (DRAP-Individual) ZA200300035-A; target-containing vectors. MX2003000038-A1 Determining primary structure of mRNA encoding recombinant endooligopeptidase A, by cloning CAMARGO A (CAMA-Individual) MARTINS DE WO2004053052-A2; cDNA prepared from mRNA that is BR 2003 CAMARGO A C (DCAM-Individual) BR200205000-A; AU2003302901-A1 extracted from human tissue, identifying and selecting EOPA cDNA, amplifying and isolating target cDNA. Bioassay for determining amount of active myostatin in animal, by amplifying and cloning promoter, WO2003006686-A; WO2003006686-A1; transfecting vector, selecting, AGRESEARCH LTD (AGRE-Non-standard) NZ512869-A; EP1404866-A1; NZ 2001 incubating, and washing myoblasts, OVITA LTD (OVIT-Non-standard) BR200211095-A; AU2002328046-A1 preparing protein extracts, and performing gene assay.

184

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO9509248-A; EP723598-A; WO9509248- A1; AU9480727-A; NO9601165-A; Methods for efficient nucleic acid EP723598-A1; FI9601283-A; CZ9600905- sequencing - are suitable for A3; BR9407712-A; JP9505729-W; sequencing long nucleic acid mols., ARCH DEV CORP (ARCH-Non-standard) NZ275194-A; CN1136330-A; HU75993-T; US 1994 including chromosomes and RNA, AU694146-B; RU2143004-C1; HU218597-B; without cloning or amplification. US2002197621-A1; KR346953-B; EP723598-B1; DE69433487-E; EP1408122- A2 EP837932-A; WO9640903-A; EP1340815-A; Cloning vitamin D3 binding protein or WO9640903-A1; AU9662535-A; its domain III in baculovirus - to US5620846-A; NO9705771-A; EP837932- produce macrophage activating YAMAMOTO N (YAMA-Individual) A1; JP11511962-W; BR9609072-A; US 1996 factors, useful in cancer, viral infection US2002055140-A1; US6410269-B1; and osteoporosis treatment. CN1191567-A; RU2198218-C2; EP1340815- A2; EP1443112-A2; CN1510147-A Human immune deficiency virus recombinant P17 protein production UNIV FEDERAL MINAS GERAIS (UYMI-Non- consists of cloning after DNA digestion BR9706072-A BR 1997 standard) for bonding, and purification of the protein. EP856520-A; EP856520-A1; AU9746908-A; Preparation of monoclonal antibodies NO9705714-A; JP10179160-A; CA2221682- against cell surface antigens used as A; ZA9710391-A; HU9702359-A2; diagnostic agents and to treat NZ329314-A; BR9706236-A; KR98063909- rheumatoid arthritis - comprises AKZO NOBEL NV (ALKU) AKZO NV (ALKU) EP 1997 A; MX9709446-A1; US6020170-A; immunising, then enriching, enriching AU733165-B; IL122233-A; US6392020-B1; and cloning B cells and then selecting US2002143150-A1; CN1188115-A; and cloning hybridoma. MX205222-B; RU2196178-C2 Isolating genes with site-specific or WO9736004-A; EP894146-A; WO9736004-A1; preferred expression in specific target AU9723116-A; NO9804489-A; EP894146-A1; cells - using repeated immuno- CZ9802865-A3; AU703262-B; CN1214738-A; FODSTAD O (FODS-Individual) HU9901786-A2; BR9708256-A; NZ331920-A; magnetic separation of cells then NO 1996 ENGEHAUSEN R (ENGE-Individual) SK9801416-A3; JP2000509250-W; cloning nucleic acid from them, used to MX9807590-A1; KR99087833-A; SK282091- identify genes which control metastatic B6; RU2180963-C2; EP894146-B1; IL126257- spread, useful e.g. in gene therapy. A; DE69725297-E

185

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO9740183-A; EP929689-A; WO9740183- A2; AU9724512-A; EP929689-A2; HU9901482-A2; US6025155-A; BR9708855- Producing satellite artificial A; NZ331815-A; US6077697-A; chromosomes or mini:chromosomes - JP2000508177-W; MX9808376-A1; BIOLOGICAL RES CENT HUNGARIAN ACAD useful for, e.g. cloning multiple proteins US2001008025-A1; NZ503055-A; US 1996 SCI (BIOL-Non-standard) of a metabolic pathway or multivalent NZ516885-A; US2003083293-A1; vaccines, etc.. CA2429724-A1; CA2429726-A1; JP2004033209-A; US6743967-B2; US2004143861-A1; AU200138957-A; AU2004201732-A1; AU773728-B2 Production of recombinant GP160 protein of human immune deficiency virus consists of DNA amplification and UNIV FEDERAL MINAS GERAIS (UYMI-Non- BR9710824-A BR 1997 digestion, cloning, bacteria standard) transformation and induction, and purification. Production of recombinant P24 protein of human immune deficiency virus consists of DNA amplification and UNIV FEDERAL MINAS GERAIS (UYMI-Non- BR9710825-A BR 1997 digestion, cloning, bacteria standard) transformation and induction, and purification. Production of recombinant BEAN 58058 virus growth factor consists of UNIV FEDERAL MINAS GERAIS (UYMI-Non- BR9710830-A BR 1997 amplification of DNA, cloning, standard) transformation and sequencing. WO9822607-A; FR2756297-A; EP946741-A; RHONE-POULENC RORER SA (RHON) WO9822607-A1; FR2756297-A1; Production of defective recombinant CNRS CENT NAT RECH SCI (CNRS) INST ZA9710516-A; AU9852261-A; NO9902464- virus using baculovirus for ROUSSY GUSTAVE (INSR) AVENTIS A; CZ9901822-A3; EP946741-A1; complementation - used for cloning PHARMA SA (AVET) LEBLOIS-PREHAUD H SK9900666-A3; FR 1996 genes and for in vivo or in vitro (LEBL-Individual) PERRICAUDET M (PERR- BR9713388-A; HU200001762-A2; expression of genes, e.g. as nucleic Individual) VIGNE E (VIGN-Individual) YEH P AU731106-B; KR2000057202-A; acid vaccines. (YEHP-Individual) GENCELL SA (GENC-Non- JP2001503993-W; MX9904449-A1; standard) US6387670-B1; US2003022356-A1; CZ293947-B6

186

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO9830683-A; EP1015572-A; WO9830683- Cloning of mammals - using activated A2; AU9860145-A; US5945577-A; nuclear transfer unit prepared from UNIV MASSACHUSETTS (UYMA-Non- BR9806872-A; CN1248288-A; EP1015572- differentiated mammalian cell or cell standard) UNIV MASSACHUSETTS US 1997 A2; US6235970-B1; MX9906464-A1; nucleus and enucleated mammalian AMHERST CAMPUS (UYMA-Non-standard) JP2001512964-W; AU742363-B; oocyte. US2002010949-A1; NZ336612-A EP853123-A; WO9830685-A; EP853123-A1; Purification and concentration of WO9830685-A2; AU9862084-A; EP961826- nucleic acid solutions by cross-flow BOEHRINGER MANNHEIM GMBH (BOEF) A2; CN1243543-A; BR9807062-A; filtration - removes endotoxin from EP 1997 ROCHE DIAGNOSTICS GMBH (HOFF) AU723817-B; JP2000513580-W; plasmid preparations, used e.g. for MX9906372-A1; KR2000069943-A; cloning, transfection, gene therapy etc. KR322398-B; CA2277165-C Cloning a mammal using a non-serum starved, differentiated mammalian cells WO9901163-A; EP1017422-A; WO9901163- as donor nuclei - useful for producing UNIV MASSACHUSETTS (UYMA-Non- A1; AU9881543-A; EP1017422-A1; offspring with organ xenografts, which standard) UNIV MASSACHUSETTS BR9811657-A; CN1265599-A; US 1997 are useful in cell transplantation AMHERST CAMPUS (UYMA-Non-standard) JP2001509361-W; MX2000000201-A1; therapy in humans, especially against AU2002301114-A1 Parkinson's disease. WO9901164-A; EP1017423-A; WO9901164- Cloning a pig using differentiated pig A1; AU9883745-A; EP1017423-A1; cells as donor nuclei - useful for BR9811659-A; producing offspring with agriculturally UNIV MASSACHUSETTS (UYMA-Non- CN1265600-A; US6235969-B1; US 1997 useful traits, and organ xenografts, standard) JP2001509362-W; AU742840-B; which are useful in cell transplantation US2002035737-A1; MX2000000202-A1; therapy in humans. NZ502124-A; US2004194159-A1 WO9937143-A; EP1049372-A; WO9937143- Cloning animals by inserting nucleus A2; AU9922377-A; BR9907193-A; UNIV HAWAII (UYHA-Non-standard) from adult somatic cells into EP1049372-A2; KR2001040370-A; WAKAYAMA T (WAKA-Individual) US 1998 enucleated oocyte, particularly for CN1306390-A; US6331659-B1; YANAGIMACHI R (YANA-Individual) producing transgenic animals. JP2002500864-W; US2002019993-A1; NZ505728-A; AU765170-B

b. STEM CELLS

187

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO200053795-A; EP1165830-A; WO200053795-A1; AU200035223-A; Mammalian lipo-derived stem cells free EP1165830-A1; ZA200106886-A; of mature adipocytes and lipo-derived BR200008552-A; US2002076400-A1; lattices useful to generate differentiated UNIV PITTSBURGH (UYPI-Non-standard) US 1999 KR2002013510-A; CN1352696-A; tissues and structures in vivo and in JP2002537849-W; US2003082152-A1; vitro. MX2001008489-A1; US6777231-B1; US2004171146-A1 WO200100650-A; EP1196426-A; WO200100650-A1; AU200059028-A; Reprogramming the life-span of a ADVANCED CELL TECHNOLOGY INC (ADCE- US2002001842-A1; EP1196426-A1; desired cell for production of embryonic Non-standard) CHAPMAN K B (CHAP- CN1362965-A; JP2003503071-W; US 1999 stem cells comprising introduction of Individual) BR200012099-A; cytoplasm from an undifferentiated cell. MX2001013450-A1; US2004199935-A1 WO200108683-A; EP1207879-A; Mobilization of stem cells and WO200108683-A1; AU200065026-A; progenitor cells using a nicotine UNIV LELAND STANFORD JUNIOR (STRD) US 2000 EP1207879-A1; BR200012787-A; receptor agonist. JP2003505506-W; US6720340-B1 Treating central nervous system WO200112236-A; EP1210106-A; damage and brain damage resulting WO200112236-A2; AU200067903-A; from stroke, involves GEN HOSPITAL CORP (GEHO) EP1210106-A2; NO200200779-A; US 1999 administering cells or stem BR200013388-A; JP2003507349-W; cells and a neural stimulant. US2004105847-A1; US6749850-B1; Novel anti-prostate stem cell antigen WO200140309-A; EP1226177-A; (PSCA) antibody that internalizes on WO200140309-A2; AU200132618-A; binding to PSCA on mammalian cell and GENENTECH INC (GETH) BR200015224-A; NO200201992-A; US 2000 inhibits growth of PSCA-expressing EP1226177-A2; KR2002047303-A; cancer cells in vivo, useful for killing JP2003515330-W; CN1413220-A; NZ518477-A PSCA-expressing cancer cells. WO200134776-A; EP1228194-A; WO200134776- A1; US6280718-B1; AU200069404-A; Obtaining human hematopoietic cells, US2002015694-A1; NO200202180-A; useful for transplanting human cells into WISCONSIN ALUMNI RES FOUND (WISC) EP1228194-A1; SE200201328-A; BR200015374- human recipient host, involves exposing KAUFMAN D S (KAUF-Individual) THOMSON J A US 1999 A; CN1387565-A; JP2003513664-W; human embryonic stem cell culture to (THOM-Individual) KR2003022766-A; US6613568-B2; mammalian hematopoietic stromal cells. MX2002004551-A1; NZ518683-A; US2004043484-A1

188

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Producing cloned embryos and adults WO200145500-A; WO200145500-A1; from cultured cells, especially PERRY A C F (PERR-Individual) MOMBAERTS AU200122793-A; EP1241936-A1; embryonic stem cells, by microinjecting P (MOMB-Individual) WAKAYAMA T (WAKA- BR200016531-A; JP2003517317-W; US 1999 nucleus of the cell into enucleated Individual) CN1423522-A; US2003213008-A1; oocyte to form a reconstituted cell and NZ519347-A allowing the cell to develop. WO200162899-A; EP1257634-A; Production of primate embryoid bodies WO200162899-A2; AU200138491-A; WISCONSIN ALUMNI RES FOUND (WISC) that adhere to a substrate comprises NO200203949-A; EP1257634-A2; THOMSON J A (THOM-Individual) MARSHALL removing the adhering colonies of the BR200108436-A; CN1404526-A; US 2000 V S (MARS-Individual) SWIERGIEL J J (SWIE- embryonic stem cells from the US6602711-B1; KR2003032921-A; Individual) substrate in clumps. JP2003523766-W; US2004023376-A1; MX2002008054-A1; NZ520700-A WO200166697-A; EP1261691-A; WO200166697-A2; AU200141973-A; Serum-free culturing of primate EP1261691-A2; NO200204200-A; WISCONSIN ALUMNI RES FOUND (WISC) embryonic stem cells in the presence BR200108507-A; CN1416345-A; US 2000 THOMSON J A (THOM-Individual) of fibroblast growth factors. KR2003032926-A; JP2003525625-W; US2003190748-A1; MX2002008698-A1; NZ520701-A WO200164234-A; EP1261360-A; Use of peptide derived from N-terminal WO200164234-A1; AU200135962-A; part of alpha S1 casein to treat and/or US2002147144-A1; EP1261360-A1; prevent autoimmune or viral disease, CHAY 13 MEDICAL RES GROUP NV (CHAY- NO200204157-A; CZ200202915-A3; IL 2000 viral infection, thrombocytopenia, or to Non-standard) SIDELMAN Z (SIDE-Individual) BR200109027-A; KR2003025907-A; induce hematopoiesis, hematopoietic CN1427725-A; JP2003528827-W; stem cell proliferation. ZA200206842-A; HU200301003-A2; MX2002008569-A1 UNIV BRITISH COLUMBIA (UYBR-Non- standard) CHEMOKINE THERAPEUTICS WO200176615-A; WO200176615-A2; CXC receptor 4 agonists that reduces CORP (CHEM-Non-standard) TUDAN C R CA2305036-A1; CA2335109-A1; hematopoietic cell multiplication and (TUDA-Individual) MERZOUK A (MERZ- AU200152081-A; US2002165123-A1; susceptibility to cytotoxic agents, are Individual) ARAB L (ARAB-Individual) SAXENA CA 2001 EP1276493-A2; BR200110049-A; useful for bone marrow or peripheral G (SAXE-Individual) EAVES C J (EAVE- US2003148940-A1; JP2003530355-W; blood stem cell transplantation. Individual) CASHMAN J (CASH-Individual) EP1276493-B1; DE60106002-E CLARK-LEWIS I (CLAR-Individual) SALARI H (SALA-Individual)

189

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Removing ras-mediated neoplastic cells from a cellular composition by contacting WO200183711-A; WO200183711-A2; the composition with reovirus which results ONCOLYTICS BIOTECH INC (ONCO-Non-standard) AU200158086-A; EP1278824-A2; BR200110474- US 2001 in oncolysis of neoplastic cells, useful for A; JP2003531606-W; MX2002010744-A1 increasing efficacy of hematopoietic stem cell transplantation. CNRS CENT NAT RECH SCI (CNRS) INST NAT RECH AGRONOMIQUE (INRG) INRA INST NAT RECH AGRONOMIQUE (INRG) ECOLE NORMALE SUPERIEURE DE LYON (ECOL- New polynucleotide, useful for identifying Non-standard) EP1280898-A; WO200185938-A1; FR2808803-A1; such cells or compounds that regulate ENS ECOLE NORMALE SUPERIEURE LYON AU200154885-A; EP1280898-A1; NO200205402- differentiation and dedifferentiation, FR 2000 (ENSE-Non-standard) A; BR200110764-A; US2004072169-A1; comprises avian nucleic acid, specific for ACLOQUE H (ACLO-Individual) BIROT A (BIRO- JP2004515212-W Galliform pluripotent stem cells. Individual) RISSON V (RISS-Individual) PAIN B (PAIN- Individual) SAMARUT J (SAMA-Individual) Treating T-cell disorder such as viral infection or acquired WO200230435-A; WO200230435-A1; immunodeficiency syndrome, comprises AU200195270-A; EP1333845-A1; BR200114595- disrupting sex steroid signaling to the UNIV MONASH (MONU) BOYD R (BOYD-Individual) AU 2000 A; JP2004509979-W; US2004132179-A1; thymus in the subject and ZA200302931-A; NZ525508-A introducing into the subject bone marrow or hemopoietic stem cells. Agents containing cofilin promoting proliferation and differentiation of WO2003057241-A; WO2003057241-A1; hematopoietic stem cells and their DAIICHI SUNTORY PHARMA CO LTD (SUNR) AU2002359951-A1; BR200207725-A; JP 2001 precursors for treatment of hematopoietic US2004157326-A1; CN1499980-A; EP1459758-A1 deficiency diseases. New lentivector with human globin gene, useful for treating hemoglobinopathies (e.g. SLOAN KETTERING INST CANCER RES (SLOK) WO2003002155-A; WO2003002155-A1; beta-thalassemia or sickle-cell SADELAIN M (SADE-Individual) RIVELLA S (RIVE- US2003022303-A1; EP1409025-A1; US 2001 disease) or for transducing hematopoietic Individual) MAY C (MAYC-Individual) BERTINO J AU2002320246-A1; BR200211307-A; CN1522160- progenitor or stem cells for treating (BERT-Individual) A hemoglobinopathy in mammals. Increasing population of progenitor and/or ANORMED INC (ANOR-Non-standard) BRIDGER G stem cells in subject J (BRID-Individual) ABRAMS M J (ABRA-Individual) WO2003011277-A2; US2003130250-A1; comprises administering conjugate HENSON G W (HENS-Individual) MACFARLAND R EP1411918-A2; KR2004020075-A; BR200211570- US 2002 comprising cyclic amine linked to second T (MACF-Individual) CALANDRA G B (CALA- A; NO200400407-A; AU2002318927-A1 amine. Individual)

190

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Isolating inner cell mass for establishing human embryonic stem WO2003018783-A; WO2003018783-A1; cell lines able to develop into RELIANCE LIFE SCI PVT LTD (RELI-Non- US2003104616-A1; EP1421181-A1; specialized cells in the US 2001 standard) AU2002334378-A1; KR2004030161-A; human body, e.g. blood, skin, muscle BR200212098-A; ZA200304132-A and nerve cells, employing a non- contact diode laser technique. TRANS-SCI INC (TRAN-Non-standard) Tailor-made pluripotent stem cells for NAKATSUJI N (NAKA-Individual) TADA T WO2003027278-A1; EP1437404-A1; production of donor organs (TADA-Individual) REPROCELL INC (REPR- KR2004031101-A; BR200212998-A; JP 2001 and tissues which do not induce Non-standard) NAKATSUJI S (NAKA-Individual) JP2004248505-A; AU2002335417-A1 immune rejection when transplanted. TRANS SCI KK (TRAN-Non-standard) Injectable bone filler for repairing osseous defect comprises calcium salt particles, organic binder having affinity for calcium WO2003028779-A; WO2003028779-A1; salt, ISOTIS NV (ISOT-Non-standard) EP1432461-A1; AU2002328023-A1; EP 2001 cells from stem cells, osteogenic KR2004062946-A; BR200213041-A cells, osteoprogenitor cells, and buffer. Directing differentiation of primate embryonic stem cells into endothelial cells, WO2003040319-A; WO2003040319-A2; WISCONSIN ALUMNI RES FOUND (WISC) by culturing stem cells in medium US2003166273-A1; LU91074-A; SE200401132-A; KAUFMAN D S (KAUF-Individual) LEWIS R (LEWI- US 2001 containing growth factors e.g. vascular EP1446476-A2; AU2002356896-A1; Individual) AUERBACH R (AUER-Individual) endothelial cell growth factor, basic BR200213815-A fibroblast growth factor. SAINT LAURENT PARFUMS YVES (SLAU-Non- Adult, multipotent human stem cells, useful standard) CENT NAT RECH SCI (CNRS) UNIV for transplantation for e.g. tissue NICE-SOPHIA ANTIPOLIS (UYNI-Non-standard) WO2004013275-A2; FR2843123-A1; reconstruction or cosmetic purposes, are RODRIGUEZ A (RODR-Individual) SAINT LAURENT AU2003278212-A1; BR200305721-A; FR 2003 isolated from adipose tissue and do not PARFUMS SA YVES (SLAU-Non-standard) CNRS US2004229351-A1 induce rejection. CENT NAT RECH SCI (CNRS) DANI C (DANI- Individual) AILHAUD G (AILH-Individual) WO9712041-A; EP859842-A; WO9712041-A1; SMITHKLINE BEECHAM CORP (SMIK) HUMAN ZA9608204-A; AU9673790-A; NO9801387-A; Novel truncated human chemokine Beta-8 GENOME SCI INC (HUMA-Non-standard) WHITE J CZ9800921-A3; EP859842-A1; CN1198186-A; poly-peptide(s) - useful for e.g. protecting (WHIT-Individual) APPELBAUM E (APPE-Individual) HU9802699-A2; BR9610671-A; AU711573-B; bone marrow stem cells from US 1995 O'SHANNESSY D (OSHA-Individual) FORNWALD J JP11512610-W; US6001606-A; MX9802380-A1; chemotherapeutic agents or stimulate A (FORN-Individual) O'DONNELL K (ODON- NZ320932-A; KR99063834-A; US2002007047-A1; wound healing. Individual) SMITHKLINE BEECHAM (SMIK) US2002061551-A1; CN1405180-A; US2003138400-A1; KR2003096447-A

191

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Use of specific chemokine(s) for stem WO9715595-A; EP866806-A; WO9715595-A1; cell mobilisation - useful for treating ZA9608896-A; AU9675209-A; NO9801818-A; EP866806-A1; CZ9801202-A3; HU9802531-A2; myelo:suppression or any condition SMITHKLINE BEECHAM CORP (SMIK) US 1995 BR9611173-A; CN1205708-A; AU712235-B; involving immuno-suppression or low JP11512747-W; MX9803217-A1; NZ321789-A; levels of haematopoietic cells. KR99066997-A WO9733611-A; EP954329-A; WO9733611-A1; Killing specific cells in population of AU9725229-A; NO9804175-A; SK9801257-A3; e.g. nucleated peripheral blood cells - HU9901597-A2; CN1218411-A; BR9708049-A; AU710184-B; EP954329-A1; CZ9802763-A3; by treatment with immuno-toxin, FODSTAD O (FODS-Individual) NZ331763-A; JP2000507230-W; NZ336576-A; NO 1996 particularly for purging stem cell MX9807252-A1; KR99087546-A; RU2182493- transplants and for direct treatment of C2; EP954329-B1; DE69714775-E; cancers. US2002151689-A1

WO9738101-A; EP904367-A; WO9738101- A1; AU9726064-A; NO9804491-A; Stem cell factor analogue N10D or CZ9803015-A3; EP904367-A1; US5885962- N10D/N11D - useful to treat AMGEN INC (AMGE-Non-standard) AMGEN A; SK9801310-A3; CN1214734-A; pigmentation disorder, AIDS, nerve US 1996 BOULDER INC (AMGE-Non-standard) BR9708578-A; HU9902768-A2; damage, infertility, intestinal damage or JP2000508170-W; MX9807807-A1; haematopoietic disorder. KR2000004951-A; AU726663-B; MX209661- B Culture system for prolonged maintenance WO9906533-A; EP1007633-A; WO9906533-A1; of primordial germ cells - includes leukemia AU9887593-A; EP1007633-A1; BR9811830-A; inhibitory factor, basic fibroblast growth UNIV MASSACHUSETTS (UYMA-Non-standard) US6156569-A; CN1273600-A; AU736087-B; US 1998 factor, stem cell factor and insulin-like MX2000001301-A1; KR2002013461-A; NZ502712- growth factor. A; JP2003532364-W; US2004226058-A1 Production of avian embryonic germ cells WO9906534-A; EP1019491-A; WO9906534-A1; by culturing primordial germ cells - in a AU9887594-A; EP1019491-A1; BR9811832-A; medium which includes leukemia inhibitory UNIV MASSACHUSETTS (UYMA-Non-standard) US 1997 CN1273599-A; MX2000001300-A1; AU738357-B; factor, basic fibroblast growth factor, stem JP2003517261-W; NZ502713-A cell factor and insulin-like growth factor. An isolated ependymal neural central nervous system stem cell useful for WO9967363-A; EP1090105-A; WO9967363-A1; treating, e.g. Alzheimer's disease, AU9949459-A; EP1090105-A1; BR9911509-A; NEURONOVA AB (NEUR-Non-standard) SE 1998 Parkinson's disease, amyotrophic lateral CN1307632-A; KR2001071601-A; JP2002518043- sclerosis, multiple sclerosis and acute W; US2003092176-A1; AU770501-B2 trauma.

192

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Treatment for damaged or scarred myocardial tissue comprises WO200006701-A; WO200006701-A1; administering a cellular suspension GENZYME CORP (GENZ) AU9955454-A; EP1100870-A1; BR9912662- US 1999 containing mesenchymal stem cells, A; JP2002521493-W used to improve cardiac function. Novel chimeric anti-CD20 antibody WO200027433-A; EP1131096-A; treatment for bone marrow transplant WO200027433-A1; AU200015970-A; and peripheral blood stem cell BR9915149-A; EP1131096-A1; IDEC PHARM CORP (IDEC-Non-standard) US 1998 transplant recipients, useful for purging KR2001099788-A; CN1330554-A; disease-causing CD20 antigen- JP2002529429-W; ZA200103716-A; expressing cells. MX2001004649-A1; US2004213784-A1 Novel use of growth hormone to EP1016413-A; WO200040260-A; stimulate the mobilization of EP1140149-A; EP1016413-A1; hematopoietic stem cells for e.g. for ARS APPLIED RES SYSTEMS HOLDING NV WO200040260-A1; AU200021039-A; EP 1998 enhancing bone marrow (ISTF) BR9916726-A; EP1140149-A1; transplantation, and for treating anemia JP2002534393-W; MX2001006681-A1; and leukemia. AU772222-B2; AU2004203355-A1

c. ENGENHARIA GENÉTICA

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Genetically engineering the biosynthetic pathways in plants WO200061771-A; EP1169462-A; involved in the accumulation of sterol MONSANTO CO (MONS) MONSANTO WO200061771-A2; AU200042316-A; compounds and tocopherol to US 1999 TECHNOLOGY LLC (MONS) EP1169462-A2; BR200010597-A; produce compounds for lowering the CN1360637-A; MX2001010304-A1 level of low density lipoprotein cholesterol in blood serum. New plant regulatory DNA sequences, WO200116307-A; EP1214402-A; useful for selectively controlling gene RENESSEN LLC (RENE-Non-standard) MONSANTO WO200116307-A2; AU200069477-A; expression and for modifying plants TECHNOLOGY LLC (MONS) MONSANTO BR200013728-A; EP1214402-A2; US 1999 through genetic engineering to have TECHNOLOGIES CO (MONS) US6506565-B1; CN1387572-A; the desired morphology, physiology, US2003131375-A1 growth or nutritional enhancement.

193

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Gene over-expression systems obtained by genetic engineering WO2003027280-A; WO2003027280- with stable transfer of genes for TOYOTA JIDOSHA KK (TOYT) TOYOTA CHUO A1; JP2003164294-A; producing useful gene products or JP 2002 KENKYUSHO KK (TOYW) JP2003164295-A; EP1437405-A1; other substances, applicable in BR200212649-A; AU2002330401-A1 modifying and analysis of functions. Coral cobra venom toxin cDNA - and prepn of the venom by FUNDACAO BUTANTAN (BUTA-Non-standard) genetic engineering or chemical BR9403020-A BR 1994 HO P L (HOPL-Individual) synthesis for prodn. of antiserum to treat snake bites. Recombinant protein P24 production - by genetic UNIV FEDERAL MINAS GERAIS (UYMI-Non- engineering techniques for use in BR9700860-A BR 1997 standard) diagnostics and possibly as anti- HIV vaccine. COMMONWEALTH SCI & IND RES ORG WO9900492-A; EP1021527-A; (CSIR) STATE QUEENSLAND DEPT PRIMARY WO9900492-A1; AU9880929-A; New promoter that is operable in IND (QUEE-Non-standard) UNIV QUEENSLAND EP1021527-A1; BR9810448-A; a plant cell - useful in genetic (UYQU) BUREAU SUGAR EXPERIMENT NZ502334-A; CN1261402-A; AU 1997 engineering for regulation of gene STATIONS (SUGA-Non-standard) UNIV AU729274-B; KR2001020526-A; expression. QUEENSLAND TECHNOLOGY (UYQU-Non- JP2002507888-W; MX9911879-A1; standard) UNIV KATHOLIEKE LEUVEN (UYLE- US6391639-B1 Non-standard) WESTVACO CORP (WEVC) KODRZYCKI R J AU9933165-A; ZA9903748-A; Genetically engineering conifers (KODR-Individual) BECWAR M R (BECW- CA2274037-A1; BR9901778-A; of the genus Pinus comprises Individual) CONNETT-PORCEDDU M B (CONN- US 1999 NZ336149-A; US2002129405-A1; particle mediated transformation. Individual) SCHWUCHOW S G (SCHW- US6518485-B1 Individual) ROHM & HAAS CO (ROHM) CARLSON G R EP965644-A; EP965644-A2; Modulating exogenous gene (CARL-Individual) CRESS D E (CRES- JP2000037189-A; AU9933900-A; expression useful for inducing or Individual) DHADIALLA T S (DHAD-Individual) BR9902283-A; CN1251389-A; suppressing expression in animal HORMANN R E (HORM-Individual) US 1999 KR2000006256-A; US6258603-B1; and plant cells for genetic LE D P (LEDP-Individual) MX9905570-A1; US2001044151-A1; engineering. NEW RHEOGENE LLC AU765306-B (NEWR-Non-standard)

194

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Use of a DNA detection technique EP999283-A; WO200028078-A; for the determination of genetic EP1127158-A; EP999283-A1; material of cocoa in e.g. SOC PROD NESTLE SA (NEST) PETIARD V WO200028078-A1; AU9964759-A; fermented beans, to determine (PETI-Individual) CROUZILLAT D (CROU- EP1127158-A1; BR9915050-A; EP 1998 cocao and/or cocoa varieties Individual) CN1325457-A; MX2001004242-A1; modified by common breeding JP2002529105-W; ZA200104563-A; techniques or genetic AU762765-B; US2004161740-A1 engineering. d. NANOBIOTECNOLOGIA

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Fabricating micro or nano scale WO9828320-A; EP943158-A; devices, e.g. optical storage media WO9828320-A2; AU9853712-A; - by exploiting self-assembling, EP943158-A2; BR9713995-A; NANOTRONICS INC hybridising, properties of nucleic KR2000057427-A; JP2001506931-W; US 1996 (NANO-Non-standard) acid with components formed on CN1287689-A; AU742310-B; surface then released and US6652808-B1; US2004115696-A1; transported to second surface. AU200227546-A

195

9. TEMA: SEGURANÇA BIOLÓGICA

Apresenta-se a seguir o título da patente que depositada no Brasil, sobre o tema segurança biológica, com seu respectivo título, depositante, número da patente, país de prioridade e ano de prioridade.

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Synthetic peptide WO9966954-A; used in protecting WO9966954-A1; animals against foot AU9948266-A; and mouth disease UNITED US6107021-A; virus infections BIOMEDICAL EP1089759-A1; US 1998 comprises helper T- INC (UNBI-Non- BR9912178-A; cell epitope and foot standard) KR2001053042-A; and mouth disease JP2002518461-W; virus epitope CN1354674-A; AU754939- conjugate. B

10. TEMA: SUSTENTABILIDADE AMBIENTAL

Não foram localizadas patentes, depositadas no Brasil, com o tema sustentabilidade ambiental. Em relação aos termos referentes à este tema, foram localizadas patentes depositadas no Brasil em dois deles ( Bioinseticida e Biofungicida). São listados nas tabelas abaixo os títulos das patentes com seus respectivos depositantes, números das patentes, país de prioridade e ano de prioridade.

196 a. BIOINSETICIDA

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. A new bioinsecticide formulation is EP1283676-A; WO200189297-A2; based on entomotoxines obtained FIOCRUZ FUNDACAO CRUZ OSWALDO BR200003314-A; AU200163674-A; from Bacillus thuringiensis var BR 2000 (FIOC-Non-standard) EP1283676-A2; ZA200200513-A; israelensis with toxic activity US2004022776-A1; MX2002000866-A1 against Dipteral insects. WO200058442-A; EP1165751-A; WO200058442-A1; AU200037657-A; US6245551-B1; US2001022968-A1; New Bacillus pumilus strain, NO200104653-A; EP1165751-A1; useful as fungicide for plant BR200009430-A; CZ200103239-A3; protection and a metabolite for AGRAQUEST INC (AGRA-Non-standard) US 1999 SK200101306-A3; KR2001112933-A; increasing insecticidal activity of HU200200562-A2; CN1351652-A; Bacillus thuringiensis. JP2002539820-W; ZA200107386-A; US6586231-B2; MX2001009695-A1; NZ514040-A; AU775016-B2 New Bacillus thuringiensis WO200066742-A; EP1173578-A; polypeptide for use as an WO200066742-A2; AU200046987-A; insecticide in protecting plants, EP1173578-A2; BR200010303-A; such as, corn, wheat, oat, MONSANTO CO (MONS) MONSANTO CZ200103894-A3; CN1360632-A; US 1999 tobacco, or potato plants and in TECHNOLOGY LLC (MONS) ZA200108918-A; US6555655-B1; controlling insect populations, MX2001011313-A1; US2003232757-A1; such as, Colorado potato beetle AU769939-B2 and southern rootworm. New synthetic gene for CryIC protein, useful for producing INRA INST NAT RECH AGRONOMIQUE WO200102579-A; FR2795739-A1; transgenic plants resistant to (INRG) CIRAD CENT COOP INT EN RECH WO200102579-A1; AU200062902-A; FR 1999 insects, provides high level AGRONOMIQUE (CIRA-Non-standard) BR200012045-A expression in plants. Lepidopteran-active Bacillus WO200119859-A; EP1218513-A; thuringiensis delta-endotoxin WO200119859-A2; AU200074916-A; MONSANTO CO (MONS) MONSANTO polypeptides and the polynucleotides EP1218513-A2; BR200014516-A; TECHNOLOGY LLC (MONS) MONSANTO US 1999 that encode them, useful for CN1390259-A; US6593293-B1; TECHNOLOGY CO (MONS) increasing the insect resistance of ZA200201610-A; MX2002002955-A1; plant. US2003237111-A1

197

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Synergistic control of insects such WO200150865-A; EP1244360-A; as cotton bollworms, involves WO200150865-A2; AU200137270-A; applying to locus, foliage or stem EP1244360-A2; CZ200202301-A3; of transgenic plant, a recombinant BASF AG (BADI) US 2000 BR200016924-A; KR2002065923-A; insect virus containing vector SK200200967-A3; HU200203815-A2; which is highly virulent to the CN1420725-A; MX2002006589-A1 insect. Indoor and outdoor extermination WO200165944-A; WO200165944-A2; of termites involves combination SDS BIOTECH CORP (SDSB-Non- JP2001253805-A; AU200141069-A; of an entomopathogenic standard) MIKAMI K (MIKA-Individual) JP 2000 KR2002081415-A; BR200109112-A; nematode and insect-growth YAMANAKA S (YAMA-Individual) US2003157062-A1; ZA200207070-A regulator a slow-acting insecticide. WO200179450-A; EP1272611-A; Streptomyces strain useful as an WO200179450-A2; AU200157595-A; insecticide for preventing or EP1272611-A2; BR200110083-A; AGRAQUEST INC (AGRA-Non-standard) US 2000 treating a plant, root or fruit from US6682925-B1; MX2002010145-A1; Lepidoptera. JP2004507221-W; ZA200209121-A; NZ522369-A AVENTIS CROPSCIENCE GMBH (AVET) KRAUSE H (KRAU-Individual) SCHNABEL Use of enveloped agrochemical, G (SCHN-Individual) FRISCH G (FRIS- WO200184928-A; EP1282353-A; especially herbicide, safener, Individual) WURTZ J (WURT-Individual) WO200184928-A1; DE10022989-A1; growth regulator, insecticide or BICKERS U (BICK-Individual) HACKER E AU200167410-A; US2002055436-A1; DE 2000 fungicide, for suppression of (HACK-Individual) AULER T (AULE- EP1282353-A1; BR200110738-A; antagonistic interactions in Individual) MELENDEZ A (MELE-Individual) CN1431863-A; JP2003532652-W agrochemical mixtures. HAASE D (HAAS-Individual) BAYER CROPSCIENCE GMBH (FARB) New bacterial insecticidal proteins, AVENTIS CROPSCIENCE NV (AVET) BAYER EP1287144-A; WO200187931-A2; useful for making insecticidal BIOSCIENCE NV (FARB) BAYER AU200170532-A; BR200110867-A; composition to protect plants from US 2000 CROPSCIENCE NV (FARB) BAYER EP1287144-A2; CN1432065-A; damage by insects especially BIOCHEMICAL SCI SA (FARB) JP2003533214-W coleopteran insects. Bacillus thuringiensis hybrid toxin H04 for controlling insects, e.g. fall army EP1311162-A; WO200215701-A2; worm or European cornborer, and for AU200185900-A; EP1311162-A2; SYNGENTA PARTICIPATIONS AG (SYGN) US 2000 creating insect resistant plants, KR2003029858-A; BR200113500-A; comprises domains I and II of Cry1Ab CN1449250-A; JP2004506432-W and domain III of Cry1C.

198

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Synergistic biological pesticide WO200237966-A; EP1332676-A; formulation, having biostimulant, WO200237966-A1; AU200214060-A; pest resistance inducing, ES2171131-A1; EP1332676-A1; fungicidal and insecticidal activity, IDEBIO SL (IDEB-Non-standard) ES 2000 BR200115298-A; ES2171131-B1; comprising entomopathogenic US2004116290-A1; EP1332676-B1; nematodes, chitosan and weak DE60104443-E acid. Plant invigorator for use as WO200280673-A; WO200280673-A1; fertilizer and insecticide, NO200304295-A; EP1379128-A1; comprises preset amount of SPENCER M D (SPEN-Individual) SK200301359-A3; KR2003096303-A; surfactants, ethanol, BROUARD R W (BROU-Individual) CAREY AU2001246694-A1; CZ200302701-A3; WOGB 2001 demineralized aqueous solution, V P (CARE-Individual) US2004116292-A1; BR200116963-A; catalytic enzyme glycosides, CN1505477-A; JP2004531509-W; colorant and lanolin. MX2003009145-A1 NAT STARCH & CHEM INVESTMENT Stable, solid formulation for HOLDING COR (NATT) ICI AMERICAS INC EP1287739-A; EP1287739-A1; application to e.g. crops, soil and (ICIL) HARTMANN F D J (HART-Individual) JP2003128504-A; CA2399748-A1; insects, comprises a chemically EDEN J L (EDEN-Individual) SOLAREK D B US2003109384-A1; BR200204318-A; US 2001 modified starch, an agricultural (SOLA-Individual) ROMMENS J C G CN1408221-A; US6667277-B2; material, a surfactant and/or (ROMM-Individual) AUDA M I (AUDA- SG105557-A1 adjuvant. Individual) NAT STARCH & CHEM INVESTMENT HOLDING CO (NATT) Controlling pests in genetically WO200262144-A; DE10104871-A1; modified vegetables that express WO200262144-A2; EP1367900-A2; insecticidal Bacillus thuringiensis AVENTIS CROPSCIENCE GMBH (AVET) KR2003074780-A; BR200206926-A; DE 2001 toxin, by application of specific, AU2002242678-A1; US2004078843-A1; synergistic pesticides. JP2004517945-W; MX2003006934-A1 Novel pesticidal toxin, designated WO200278437-A; EP1377157-A; SYNGENTA PARTICIPATIONS AG (SYGN) Vip3 toxins from Bacillus EP1377157-A4; WO200278437-A2; MILES P (MILE-Individual) KRAMER V thuringiensis, useful for controlling EP1377157-A2; HU200303738-A2; (KRAM-Individual) SHEN Z (SHEN- US 2001 insects, e.g., lepidopteran insect, BR200208589-A; AU2002307058-A1; Individual) SHOTKOSKI F (SHOT-Individual) is highly active against a wide US2004133942-A1; ZA200307266-A; WARREN G W (WARR-Individual) range of insect pests. CN1527663-A Mixtures of gamma-cyhalothrin WO2003011031-A; WO2003011031-A1; and other active ingredients useful EP1414304-A1; KR2004018509-A; SYNGENTA LTD (SYGN) GB 2001 for combating or controlling insect, AU2002345228-A1; BR200211298-A; acarine or nematode pests. MX2004000661-A1

199

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO9502058-A; EP707654-A; New transposon Tn5401 from WO9502058-A2; AU9473616-A; Bacillus thuringiensis and US5441884-A; WO9502058-A3; fragments of it - and related ECOGEN INC (ECOG-Non-standard) BR9406881-A; EP707654-A1; US 1994 plasmids and transformed B. US5650308-A; US5843744-A; thuringiensis useful as JP11507801-W; EP707654-B1; insecticides. ES2139086-T3; CA2166691-C Dispersible insecticidal powder - contains dried caterpillars with EMPRESA BRASIL PESQUISA BR9501189-A BR 1995 terminal infection for control of AGROPECUARIA (EMPR-Non-standard) lepidoptera larvae. Insecticide mixts based on EP677247-A; EP677247-A1; DE4412834- Bacillus spp. - also contain an A1; JP7285818-A; BR9501569-A; agonist or antagonist of BAYER AG (FARB) DE 1994 CA2146822-A; ZA9503065-A; nicotinergic acetylcholine CN1112392-A receptors of insects.. Pheromone compsn. to protect EP680693-A; EP680693-A1; crops from insects and mites - DE19515744-A1; FR2719450-A1; comprises thermoplastic FI9502177-A; CA2148760-A; JP8040813- elastomer with polyether gps., ELF ATOCHEM SA (AQOR) A; US5504142-A; BR9501933-A; FR 1994 pheromone, kairomone or CN1122651-A; JP2757347-B2; allomone and undecylenic acid KR145993-B1; CA2148760-C; (deriv.). MX195933-B; CN1058368-C WO9533380-A; EP765120-A; WO9533380- Synergistic pesticidal compsn esp. for A1; AU9526166-A; ZA9504683-A; controlling insects and acarids - CIBA GEIGY AG (CIBA) BR9502710-A; EP765120-A1; JP10502055- CH 1994 comprises lufenuron and a second W; KR97703706-A; MX9606168-A1; active agent e.g. abamectin. CN1150381-A; IL113957-A EP697170-A; EP697170-A1; AU9527219-A; BR9503455-A; CA2154640-A; CZ9501928- A3; JP8109103-A; SK9500952-A3; AMERICAN CYANAMID CO (AMCY) UNIV Prodn. of coated pesticidal agent, esp. ZA9506277-A; US5662897-A; NZ272661-A; GEORGIA RES FOUND (UYGE-Non-standard) insecticidal virus - using pH- HU76656-T; HU214499-B; US5858353-A; UNIV GEORGIA RES FOUND INC (UYGE-Non- US 1994 dependent polymer and ultraviolet IL114740-A; US5965123-A; AU710501-B; standard) WYETH HOLDINGS CORP (AMHP) protector. TW381003-A; CN1142889-A; RU2152152-C2; BASF AG (BADI) CN1164871-A; MX197686-B; SK283015-B6; KR398307-B; EP697170-B1; DE69532983-E; MX196810-B

200

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. EP712575-A; US5506251-A; EP712575- Synergistic insecticide compsns. A1; AU9536671-A; CA2160967-A; contg. hydrazine deriv. - and ROHM & HAAS CO (ROHM) JP8225405-A; BR9505187-A; cytochrome P450 inhibitor, used US 1994 THIRUGNANAM M (THIR-Individual) CN1132026-A; TW321587-A; EP712575- for controlling Southern armyworm B1; DE69510157-E; AU706558-B; and soybean looper. ES2132539-T3 WO9525430-A; WO9525430-A1; AU9521261-A; EP751710-A1; BR9507158-A; US5683689-A; Control of insect pests with JP9510713-W; KR97701499-A; biological pesticide - specifically UNIV FLORIDA (UYFL) NZ283256-A; AU696508-B; AU9896107- US 1994 Beauveria bassiana No. 447 or B. A; MX9604228-A1; NZ330232-A; bassiana SP111. AU727230-B; CN1147754-A; US6254864-B1; CA2185811-C; KR318221-B WO9526410-A; WO9526410-A2; New insecticidal recombinant AU9519570-A; WO9526410-A3; baculovirus - comprises a EP752001-A1; BR9507195-A; polyhedron gene and a ZENECA LTD (ZENE) JP9510871-W; AU688011-B; GB 1994 heterologous gene expressing an KR97702372-A; NZ282463-A; insecticidal protein with different US5885569-A; MX9604199-A1; promoters. CN1147275-A New DNA encoding new CryIE WO9534656-A; EP764210-A; type Bacillus thuringiensis toxins - WO9534656-A1; AU9524177-A; which are active against Heliothis CIBA GEIGY AG (CIBA) US5530195-A; EP764210-A1; US 1994 spp. also useful as insecticide BR9507973-A; JP10502525-W; against Lepidoptera. NZ285165-A; MX9606262-A1 EP765117-A; WO9535031-A; WO9535031-A1; AU9526656-A; ZA9504989-A; EP765117-A1; New compsn. for controlling BR9508041-A; AU688054-B; NZ287816- insects - comprising an A; JP10504278-W; KR97703700-A; aminopeptidase inhibitor or a UNIV LA TROBE (UYLT-Non-standard) AU 1994 MX9606538-A1; metallo-peptidase inhibitor and a US5985273-A; IL114191-A; CN1158551- weakly chelating peptidase. A; PH1199550734-B1; EP765117-B1; DE69532582-E; ES2214502-T3

201

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO9602638-A; WO9602638-A1; ZA9505830-A; AU9529804-A; FI9700103- Formulation contg. A; NO9700136-A; EP770126-A1; CIBA GEIGY AG (CIBA) NOVARTIS- microorganisms for use in CZ9700092-A3; SK9700031-A3; ERFINDUNGEN VERWALTUNGS GMBH horticulture - for protection of HU76428-T; BR9508398-A; (NOVS) NOVARTIS AG (NOVS) ENZMANN CH 1994 plants against weeds, insects and KR97704873-A; HU214917-B; NZ289842- M (ENZM-Individual) BAETTIG W (BAET- disease, has high viability and A; TW345486-A; JP11505403-W; Individual) rapid release characteristics. AU705188-B; IL114573-A; SK280088-B6; MX9700377-A1; RU2160990-C2; CN1152936-A; US2002015988-A1 DNA molecule from Autographa WO9603509-A; EP775208-A; californica nuclear polyhedrosis WO9603509-A2; AU9532031-A; virus - useful for generating an AMERICAN CYANAMID CO (AMCY) WO9603509-A3; ZA9506276-A; US 1994 insect virus with improved killing EP775208-A1; BR9508441-A; time for insect pests. AU692290-B; MX9600235-A1 WO9603048-A; WO9603048-A1; Synergistic compsn. for control of AU9532029-A; ZA9506274-A; EP772399- lepidopteran pests - contains A1; BR9508445-A; HU76840-T; chemical insecticide and MX9700646-A1; JP10503650-W; genetically modified insect virus, AMERICAN CYANAMID CO (AMCY) US 1995 TW326384-A; KR97704355-A; either expressing a toxin or not CZ9700201-A3; NZ291028-A; AU708560- expressing ecdysteroid UDP- B; HU221352-B1; CN1162906-A; glucosyl transferase. RU2200394-C2 EP768824-A; WO9601055-A; WO9601055- A1; AU9526506-A; EP768824-A1; Control of insect, acarid or nematode BR9508982-A; JP10507065-W; KR97704356- pests with increased speed of kill - A; AU695075-B; NZ287698-A; MX9606624- using recombinant insect virus UNIV CALIFORNIA (REGC) A1; CN1159143-A; US6344193-B1; US 1994 expressing foreign protein or toxin and TW505506-A; EP768824-B1; MX210646-B; organic insecticide. ES2204953-T3; ZA9508847-A; US2002037275-A1; US6596271-B2; PH1199651625-B1 Use of yeast for control of moth and STATE NEW SOUTH WALES (NEWS-Non- EP785720-A; WO9609765-A; WO9609765- other insect pests - esp. cotton standard) NEW SOUTH WALES NSW DEPT A1; AU9535984-A; ZA9508090-A; EP785720- bollworm and native budworm; control AGRIC (NEWS-Non-standard) EL ESTADO A1; MX9702188-A1; BR9509094-A; AU 1994 is more economical and NUEVA GALES DEPT AGRIC (ELES-Non- AU708200-B; CN1159144-A; US6274137-B1; environmentally safer than with standard) NEW SOUTH WALES DEPT AGRIC US2001024646-A1; US6544513-B2; pesticides. (NEWS-Non-standard) MX213905-B; EP785720-B1; DE69533553-E

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO9610083-A; EP792363-A; EP1382611- A; WO9610083-A1; AU9537433-A; ZA9508121-A; EP792363-A1; BR9509099- A; MX9702212-A1; HU77449-T; US5770696-A; AU692934-B; JP10506532- Bacillus strain producing insecticidal W; KR97706392-A; US5840868-A; protein during vegetative growth - US5849870-A; US5866326-A; US5872212- CIBA GEIGY AG (CIBA) US 1995 used in the control of Lepidoptera A; US5889174-A; US5888801-A; and Coleoptera pests. US5990383-A; CZ9700908-A3; CN1160420-A; CZ290801-B6; RU2196824- C2; TW496896-A; HU222264-B1; EP792363-B1; EP1382611-A2; PH1199551386-B1; DE69532333-E; ES2213162-T3; KR419438-B WO9616171-A; WO9616171-A1; Bracon hebetor toxins and DNA AU9538777-A; ZA9509844-A; EP792361- encoding them - useful in biological ZENECA LTD (ZENE) COMMONWEALTH SCI A1; BR9509744-A; HU77119-T; GB 1995 control agents to combat insect & IND RES ORG (CSIR) MX9703764-A1; KR97707284-A; pests. JP10511543-W; TW342413-A; AU713922- B; US6156536-A; CN1172503-A EP798961-A; WO9619112-A; WO9619112- Synergistic insecticidal and A1; DE4445732-A1; AU9643435-A; acaricidal combinations for use in EP798961-A1; BR9510378-A; HU77792-T; e.g. cotton - contain nitro- HOECHST-SCHERING AGREVO GMBH MX9704725-A1; KR98700006-A; DE 1994 methylene, para-pyrethroid, (AGRE) HOECHST AG (FARH) US5888989-A; TW350755-A; JP11507010- carbamate or phenyl-pyrazole and W; AU715520-B; MX203369-B; insect pathogenic fungus. CN1171032-A WISCONSIN ALUMNI RES FOUND (WISC) ENSIGN J C (ENSI-Individual) BOWEN D J (BOWE-Individual) PETELL J (PETE-Individual) FATIG R (FATI-Individual) SCHOONOVER S WO9717432-A; EP797659-A; WO9717432- Photorhabdus sp. insecticidal protein (SCHO-Individual) FFRENCH-CONSTANT R H A1; AU9710509-A; EP797659-A1; toxins and DNA encoding them - can (FFRE-Individual) ROCHELEAU T A (ROCH- BR9606889-A; SK9700931-A3; KR98701244- be genetically engineered into insect Individual) BLACKBURN M B (BLAC-Individual) A; HU9900768-A2; AU729228-B; US 1996 larvae food and plants for insect HEY T D (HEYT-Individual) MERLO D J (MERL- JP2002509424-W; US6528484-B1; control. Individual) ORR G L (ORRG-Individual) KR354530-B; US2003207806-A1; JP3482214- ROBERTS J L (ROBE-Individual) STRICKLAND B2; RU2216174-C2; JP2004089189-A J A (STRI-Individual) GUO L (GUOL-Individual) CICHE T A (CICH-Individual) SUKHAPINDA K (SUKH-Individual)

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO9636221-A; WO9636221-A2; AU9657887-A; WO9636221-A3; Control of insects, acarids and EP838999-A2; NZ308294-A; US5756340- nematodes - using novel scorpion A; JP11501521-W; AU710774-B; UNIV CALIFORNIA (REGC) US 1995 toxins or a combination of 2 or MX9708495-A1; BR9608474-A; more insect toxins. KR99008424-A; US6162430-A; KR253766-B1; MX196622-B; CN1185718-A WO9636712-A; EP826047-A; New recombinant baculovirus WO9636712-A1; AU9658651-A; insecticides - contg. synthetic, EP826047-A1; JP10509596-W; baculovirus codon-biased genes DU PONT DE NEMOURS & CO E I (DUPO) NZ308772-A; BR9608741-A; US 1995 encoding insect-selective MX9708798-A1; US6096304-A; neurotoxin(s). AU723612-B; JP3252854-B2; EP826047- B1; CN1184504-A DNA encoding the Helicoverpa WO9708197-A1; AU9671526-A; armigera granulo:virus enhancin BOYCE THOMPSON INST PLANT RES US5717069-A; EP847401-A1; AU704561- protein - used to increase US 1996 (BOYC-Non-standard) B; BR9610122-A; CA2227308-C; infectivity of baculovirus for control JP2002504803-W of insect pests. WO9723636-A; WO9723636-A1; Controlling expression of AU9716873-A; EP876497-A1; insecticidal proteins - using DU PONT DE NEMOURS & CO E I (DUPO) CN1205741-A; BR9612268-A; recombinant baculovirus UNIV MARYLAND BALTIMORE (UYMA- US 1996 MX9804689-A1; JP2000507089-W; containing tetracycline Non-standard) KR99076627-A; AU727423-B; trans:activator protein. US6322781-B1; ZA9705495-A Enhancing activity of agricultural WO9823157-A; EP944315-A; active products - such as growth WO9823157-A1; AU9714610-A; regulators, herbicides, fungicides EP944315-A1; CN1244771-A; NZ336424- MICRO FLO CO (MICR-Non-standard) WOUS 1996 or insecticides, using enhancer of A; BR9612796-A; MX9904920-A1; spores, cultures or suspensions of US6232270-B1; AU738993-B; Bacillus or soil bacteria. MX210622-B GB2315217-A; FR2751176-A1; JP10081602- Poison bait for controlling noxious A; GB2315217-B; BR9703971-A; SUMITOMO CHEM CO LTD (SUMO) insects - comprises fermented milk KR98007988-A; ES2131007-A1; ES2131007- JP 1996 SUMITOMO KAGAKU KOGYO KK (SUMO) product as appetite stimulating factor. B1; TW368393-A; IT1296317-B; CN1174660- A

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO9740692-A; EP900024-A; WO9740692- Composition for controlling insects A1; ZA9703630-A; AU9726992-A; EP900024- and acarids - comprises one or more A1; CN1220578-A; BR9709181-A; AU718566- perhydro-oxadiazine derivatives and NOVARTIS AG (NOVS) B; JP2000509379-W; MX9808969-A1; CH 1996 another pesticide, such as pirimicarb, KR2000065069-A; CN1401234-A; EP900024- terbufos, diethion, ethofenprox or B1; DE69722930-E; TW526044-A; ivermectin.. ES2202609-T3; US2004176369-A1 Strains of Bacillus thuringiensis with increased production of CryI crystal WO9802039-A; WO9802039-A1; AU9735994- protein - and normal sporulation ECOGEN INC (ECOG-Non-standard) A; US5804180-A; BR9710320-A; MX9900653- US 1996 properties, useful as insecticide for A1; MX214692-B control of Lepidoptera pests. Orally active insecticidal composition, UK MIN AGRIC FISHERIES & FOOD (UKAG- WO9808388-A; WO9808388-A1; AU9740249- used for protection of crops or animals Non-standard) UK MIN FISHERIES & FOOD A; ZA9707373-A; EP923295-A1; BR9711285- - contains pesticidal material from (UKAG-Non-standard) JARRETT P (JARR- A; CN1233938-A; NZ334847-A; AU732845-B; GB 1996 Xenorhabdus species optionally Individual) ELLIS D J (ELLI-Individual) MORGAN MX9901878-A1; JP2001508032-W; synergised with Bacillus thuringiensis J A W (MORG-Individual) US2003213012-A1; RU2225114-C2 toxin. WO9813498-A; EP1015592-A; WO9813498- Bacillus thuringiensis CryET33 and A1; AU9748033-A; CN1241213-A; CryET34 proteins - having activity US6063756-A; EP1015592-A1; BR9713219- against Coleoptera insects, ECOGEN INC (ECOG-Non-standard) A; KR2000048593-A; US6248536-B1; US 1996 particularly boll weevil, red flour beetle US6326351-B1; JP2001523944-W; and Japanese beetle. AU741704-B; US6399330-B1; US2002128192-A1; US2003144192-A1 WO9822595-A; WO9822595-A1; ZA9710429-A; AU9853628-A; EP942985- A1; US6017534-A; US6110464-A; US6156573-A; CN1268180-A; JP2001502555-W; US6221649-B1; New nucleic acid encoding Bacillus US6242241-B1; MX9904675-A1; thuringiensis hybrid delta toxins - BR9713373-A; US6281016-B1; with increased and broader ECOGEN INC (ECOG-Non-standard) US6326169-B1; AU742971-B; US 1997 spectrum activity, used to produce US2002064865-A1; US2003017571-A1; transgenic plants with increased US6521442-B2; US6538109-B2; resistance to insects. US2003119158-A1; US2003182682-A1; US6645497-B2; US2004093637-A1; US6746871-B2; US2004171120-A1; EP942985-B1; DE69730730-E

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Plutella xylostella baculovirus for control of insect pests - useful as WO9823148-A1; AU9853696-A; biological control agent for insects US SEC OF AGRIC (USDA) US DEPT OF US6042843-A; BR9713413-A; of order Lepidoptera, e.g. US 1996 COMMERCE (USDC) AU722851-B; KR2000057225-A; diamondback moth, Plutella MX9904821-A1; JP2002506422-W xylostella, or Spodoptera exigua etc.. WO9823641-A; WO9823641-A1; New Bacillus thuringiensis nucleic ZA9710431-A; AU9853717-A; acid segments - comprising delta- US5942664-A; EP942929-A1; endotoxin gene fragments, used ECOGEN INC (ECOG-Non-standard) BR9713555-A; CN1245502-A; US 1996 for the control of insects, US6153814-A; US6177615-B1; particularly Lepidopteran pests. MX9904903-A1; JP2001506490-W; AU745431-B WO9827218-A; WO9827218-A2; FR2758045-A1; ZA9711359-A; New transgenic NOVARTIS AG (NOVS) UNIV OHIO STATE AU9860901-A; BE1011397-A3; monocotyledonous plants - (OHIS) US SEC OF AGRIC (USDA) US EP946102-A2; US6002068-A; comprising recombinant DNA DEPT OF AGRICULTURE (USDA) UNIV US 1996 CN1240484-A; BR9714150-A; encoding a peroxidase, used for OHIO STATE RES FOUND (OHIS) HU200000643-A2; MX9905746-A1; protecting plants against insects. NOVARTIS FINANCE CORP (NOVS) KR2000069581-A; AU735312-B; JP2001510337-W; IT1300494-B WO9821966-A; EP938262-A; New Bacillus chitinosporus strain, AGRAQUEST INC (AGRA-Non-standard) US5733544-A; WO9821966-A2; mutants, culture and isolated toxic UNIV SASKATCHEWAN (UYSA-Non- AU9872968-A; EP938262-A2; US 1996 metabolite - useful as a standard) BR9714356-A; NZ335582-A; AU724801- nematocide and insecticide. B; MX9904395-A1; JP2001505422-W EP861901-A; EP861901-A2; AU9852161- Transgenic insect viruses for A; CA2228195-A; HU9800113-A2; insect pest control - containing CANADA MIN NATURAL RESOURCES ZA9800475-A; JP10262669-A; DNA encoding developmentally (CNDG) CANADIAN GOVERNMENT US5891431-A; SG60187-A1; US 1997 regulated insect transcription (CNDG) KR98070711-A; MX9800646-A1; factor. BR9800445-A; AU743526-B; MX203299- B; CA2228195-C; CN1190128-A Use of hypersensitive response WO9837752-A; EP1028616-A; elicitor polypeptide - for CORNELL RES FOUND INC (CORR) WO9837752-A1; AU9866664-A; US 1997 application to plants or seeds or US5977060-A; FI9901824-A;

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. transgenic plants or seeds for the BR9807632-A; NZ337461-A; EP1028616- control of insects.. A1; CN1253471-A; KR2000075771-A; AU740564-B; JP2001519778-W; MX9907808-A1 WO9844137-A; EP972062-A; WO9844137-A2; ZA9802801-A; New VIP3A(c) protein and AU9868325-A; US5877012-A; EP972062- homologues active against plant A2; HU200000295-A2; BR9808483-A; pests - used in entomocidal US6107279-A; CN1256712-A; compositions for controlling NOVARTIS AG (NOVS) US 1997 US6137033-A; AU727218-B; insects and arachnids, e.g. MX9909043-A1; KR2001006015-A; Lepidoptera and Coleoptera US6291156-B1; JP2001524817-W; species. US6429360-B1; RU2222597-C2; MX219628-B; US2002078473-A1 WO9850422-A; EP981540-A; WO9850422-A1; AU9874767-A; NO9905462-A; EP981540-A1; New Bacillus subtilis strain AQ713 BR9809282-A; CN1255143-A; and its metabolites - showing SK9901490-A3; CZ9903757-A3; bactericidal, fungicidal and AGRAQUEST INC (AGRA-Non-standard) US 1997 AU732724-B; NZ500506-A; MX9910078- insecticidal activity, useful in plant A1; JP2001507237-W; HU200004555-A2; protection. KR2001012392-A; SK283036-B6; JP2003199558-A; JP3471815-B2; MX214455-B WO9857542-A; EP989804-A; WO9857542-A1; AU9873672-A; Insect repellent composition - US5929113-A; EP989804-A1; AGRAQUEST INC (AGRA-Non-standard) comprises ratite oil or its active BR9810751-A; CN1283959-A; US 1997 PE CORP NY (PEKE) fraction or fatty acids. MX9911677-A1; NZ501679-A; JP2002504141-W; AU756465-B; US6538027-B2; MX215528-B WO9903328-A; EP1018863-A; WO9903328- A1; AU9883250-A; EP1018863-A1; New insecticidal toxin genes - SK200000050-A3; CN1270497-A; extracted from Xenorhabdus COMMONWEALTH SCI & IND RES ORG (CSIR) HU200004944-A2; JP2001510022-W; AU 1997 nematophilus A24 and Photorhabdus KR2001040231-A; BR9810901-A; AU744145- luminescens. B; US6630619-B1; US2004055036-A1; AU744145-B2

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO9907207-A; EP1003377-A; New hypersensitive response US6172184-B2; WO9907207-A1; eliciting (dspE) gene and protein - AU9887585-A; EP1003377-A1; useful for providing transgenic CORNELL RES FOUND INC (CORR) FI200000237-A; BR9811074-A; US 1997 plants and seeds with enhanced US6172184-B1; AU730055-B; growth, and insect and disease CN1274259-A; MX2000001201-A1; resistance. KR2001022647-A; JP2001513323-W WO9907864-A1; AU9887625-A; Controlling homopteran insect US6051550-A; EP1027446-A1; pests - using toxins obtained from MYCOGEN CORP (MYCO) BR9812275-A; JP2001512686-W; US 1997 Bacillus thuringiensis isolates. KR2001022626-A; AU745617-B; MX2000001353-A1; NZ502393-A KANG S K (KANG-Individual) JE Y H (JEYH-Individual) JIN B R (JINB-Individual) KANG S G (KANG-Individual) JEH Y H WO9951721-A; EP1066372-A; (JEHY-Individual) PARK H W (PARK- New recombinant baculovirus, WO9951721-A1; AU9897645-A; Individual) NOH J Y (NOHJ-Individual) used for the production of KR99079361-A; EP1066372-A1; DONGBU HANNONG CHEM CO LTD KR 1998 insecticides, or medical agents or CN1292817-A; BR9815793-A; (DONG-Non-standard) KANG S (KANG- for use in vaccines. US6338846-B1; KR264953-B; AU742821- Individual) JE Y (JEYY-Individual) JIN B B; JP2002510483-W; MX2000009707-A1 (JINB-Individual) PARK H (PARK-Individual) ROH J (ROHJ-Individual) CHANG J (CHAN- Individual) CHANG J H (CHAN-Individual) DOW AGROSCIENCES LLC (DOWC) WISCONSIN ALUMNI RES FOUND (WISC) ENSIGN J C (ENSI-Individual) BOWEN D J WO9850427-A; EP915909-A; (BOWE-Individual) TENOR J L (TENO- Controlling insects using WO9850427-A1; AU9871758-A; Individual) CICHE T A (CICH-Individual) Xenorhabdus protein toxins - EP915909-A1; CN1229413-A; PETELL J K (PETE-Individual) US 1997 comprises incorporating the US6048838-A; MX9901288-A1; STRICKLAND J A (STRI-Individual) ORR G protein toxin into insect's diet. US6379946-B1; US2002147148-A1; L (ORRG-Individual) FATIG R O (FATI- AU755389-B; BR9900622-A Individual) BINTRIM S B (BINT-Individual) FFRENCH-CONSTANT R H (FFRE- Individual) NOVARTIS AG (NOVS) NOVARTIS- WO9935910-A; WO9935910-A2; Control of pests in transgenic ERFINDUNGEN VERW GES MBH (NOVS) FR2773673-A1; ZA9900275-A; CH 1998 plant crops using insecticides. SYNGENTA PARTICIPATIONS AG (SYGN) AU9927168-A; NL1011058-C2;

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. SYNGENTA CROP PROTECTION INC GB2348606-A; DE19982478-T; (SYGN) LEE B (LEEB-Individual) BR9907013-A; CN1291863-A; HU200100555-A2; KR2001024861-A; MX2000006965-A1; IT1306203-B; AU745763-B; JP2002509084-W; US6486157-B1; ES2184590-A1; NZ505601-A; US2003153591-A1; CH693621-A5 WO9958705-A; WO9958705-A1; AU9938856-A; EP1076717-A1; New recombinant baculovirus- CZ200004156-A3; ZA200006301-A; based biological insecticides used AMERICAN CYANAMID CO (AMCY) US HU200101684-A2; SK200001685-A3; US 1998 to protect against the SEC OF AGRIC (USDA) BASF AG (BADI) KR2001043627-A; CN1310767-A; diamondback moth. JP2002514435-W; NZ507918-A; AU753930-B; BR9910515-A; MX2000010981-A1 WO9963829-A; EP1083795-A; DE19825333-A1; WO9963829-A2; HOECHST-SCHERING AGREVO GMBH Use of compositions containing AU9943726-A; BR9911616-A; (AGRE) AVENTIS CROPSCIENCE GMBH DE 1998 one or more insecticides. EP1083795-A2; US6331531-B1; (AVET) ZA200006870-A; MX2000012008-A1; AU765028-B WO200009697-A; EP1104471-A; New isolated Bacillus laterosporus MYCOGEN CORP (MYCO) SCHNEPF H E WO200009697-A2; AU9953948-A; toxins, useful for controlling pests (SCHN-Individual) NARVA K E (NARV- BR9912910-A; EP1104471-A2; such as plant coleopteran insect Individual) STOCKHOFF B A (STOC- US6297369-B1; CN1319138-A; US 1999 pests including corn rootworm, Individual) LEE S F (LEES-Individual) WALZ MX2001001547-A1; US2002120114-A1; and for producing pest resistant M (WALZ-Individual) STURGIS B (STUR- JP2002522077-W; US6605701-B2; plants. Individual) AU767891-B; US2004097721-A1 WO200018920-A; EP1117786-A; Novel trypsin modulating oostatic WO200018920-A2; AU9964053-A; factor (TMOF) receptors used to UNIV FLORIDA (UYFL) BOROVSKY D BR9914111-A; EP1117786-A2; US 1998 identify new insect pest control (BORO-Individual) US2002132302-A1; NZ510339-A; agents. AU769139-B; MX2001003246-A1 Treatment or prevention of insect WO200029426-A; EP1131342-A; infestation on plants and fruit, AGRAQUEST INC (AGRA-Non-standard) WO200029426-A1; US6103228-A; US 1998 using Bacillus subtilis AQ713 or its AU200012233-A; NO200102344-A;

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. culture broth or metabolites, e.g. EP1131342-A1; CZ200101620-A3; for control of corn rootworm. BR9915339-A; SK200100656-A3; KR2001075707-A; CN1335854-A; HU200104242-A2; US6417163-B1; JP2002530290-W; US2003186852-A1; MX2001004814-A1; US6638910-B2 Novel delta endotoxin polypeptide of bacillus thuringiensis useful for WO200026378-A; EP1129198-A; controlling lepidopteran or WO200026378-A1; AU200019068-A; MONSANTO CO (MONS) MONSANTO coleopteran insect population EP1129198-A1; BR9915828-A; US 1998 TECHNOLOGY LLC (MONS) comprises at least ten contiguous US6468523-B1; ZA200103164-A; amino acids of a specific US2003068335-A1; MX2001004361-A1 sequence.

b. BIOFUNGICIDA

PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. WO200058442-A; EP1165751-A; WO200058442-A1; AU200037657-A; US6245551-B1; US2001022968-A1; New Bacillus pumilus strain, NO200104653-A; EP1165751-A1; useful as fungicide for plant BR200009430-A; CZ200103239-A3; protection and a metabolite for AGRAQUEST INC (AGRA-Non-standard) US 1999 SK200101306-A3; KR2001112933-A; increasing insecticidal activity of HU200200562-A2; CN1351652-A; Bacillus thuringiensis. JP2002539820-W; ZA200107386-A; US6586231-B2; MX2001009695-A1; NZ514040-A; AU775016-B2 Use of enveloped agrochemical, AVENTIS CROPSCIENCE GMBH (AVET) WO200184928-A; EP1282353-A; especially herbicide, safener, KRAUSE H (KRAU-Individual) SCHNABEL WO200184928-A1; DE10022989-A1; growth regulator, insecticide or G (SCHN-Individual) FRISCH G (FRIS- AU200167410-A; US2002055436-A1; DE 2000 fungicide, for suppression of Individual) WURTZ J (WURT-Individual) EP1282353-A1; BR200110738-A; antagonistic interactions in BICKERS U (BICK-Individual) HACKER E CN1431863-A; JP2003532652-W agrochemical mixtures. (HACK-Individual) AULER T (AULE-

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. Individual) MELENDEZ A (MELE-Individual) HAASE D (HAAS-Individual) BAYER CROPSCIENCE GMBH (FARB) Synergistic biological pesticide WO200237966-A; EP1332676-A; formulation, having biostimulant, WO200237966-A1; AU200214060-A; pest resistance inducing, ES2171131-A1; EP1332676-A1; fungicidal and insecticidal activity, IDEBIO SL (IDEB-Non-standard) ES 2000 BR200115298-A; ES2171131-B1; comprising entomopathogenic US2004116290-A1; EP1332676-B1; nematodes, chitosan and weak DE60104443-E acid. Conc. stable aq. suspensions of EP678241-A; EP678241-A1; AU9516355- polyene fungicides, e g A; JP7285801-A; BR9501517-A; natamycin - by addn of thickener GIST-BROCADES BV (KONN) GIST- CA2146793-A; ZA9502979-A; NZ270906- EP 1994 and pH control, used for BROCADES NV (KONN) DSM NV (STAM) A; US5552151-A; AU688856-B; immersion or coating of food, EP678241-B1; DE69514403-E; feed or agricultural prod.. ES2143586-T3; MX204361-B WO9520646-A; EP742816-A; WO9520646-A1; FI9400463-A; AU9515386-A; FI95598-B; NO9603178-A; CZ9602190-A3; EP742816-A1; New strains of Nectria pityrodes SK9600973-A3; JP9508274-W; HU74599- for use as bio-fungicides - partic. KEMIRA AGRO OY (KEMH) VERDERA OY T; KR97700761-A; AU686311-B; for control of Fusarium; also new FI 1994 (VERD-Non-standard) NZ278907-A; US5811090-A; BR9507052- method for selecting fungicidal A; MX9602967-A1; SK280507-B6; microorganisms. CN1144534-A; RU2154381-C2; MX195114-B; CZ289942-B6; HU220838- B1; EP742816-B1; DE69528753-E; ES2185694-T3; KR361473-B EP756454-A; WO9528085-A; SVENSKA LANTMAENNEN WO9528085-A1; SE9401307-A; RIKSFOERBUND EK.FOER (SVLA-Non- SE502660-C2; AU9523547-A; New Pseudomonas chlororaphis standard) SVENSKA LANTMAENNEN NO9604359-A; EP756454-A1; FI9604162- strain - is useful as a fungicide, RIKSFOERBUND (SVLA-Non-standard) A; CZ9603025-A3; SK9601310-A3; SE 1994 e.g. against Drechslera teres in SVENSKA LANTMAENNEN (SVLA-Non- NZ284874-A; BR9507322-A; HU75369-T; barley. standard) SVENSKA LANTMAENNENS KR97701995-A; JP10502803-W; (SVLA-Non-standard) BIOAGRI AB (BIOA- AU690683-B; US5900236-A; EP756454- Non-standard) B1; DE69511691-E; ES2139204-T3;

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. RU2143199-C1; CZ287510-B6; CN1148791-A; SK281576-B6; HU220582- B1; KR358671-B; NO316012-B1; RO118786-B1; JP3536180-B2 WO9710716-A; EP859549-A; WO9710716-A1; AU9672129-A; ZA9607964-A; EP859549-A1; CZ9800881- A3; SK9800381-A3; CN1196657-A; Synergistic fungicidal agent, esp. HU9802728-A2; BR9610574-A; for control of Botrytis - contains BASF AG (BADI) JP11511469-W; MX9802157-A1; DE 1995 cytochrome complex III inhibitor NZ319577-A; AU721957-B; KR99063657- and fungicidal amide cpd.. A; TW384208-A; IL123632-A; US6169056- B1; EP859549-B1; DE59607511-G; ES2162096-T3; SK283107-B6; MX211504-B WO9712520-A; EP855859-A; WO9712520-A1; FR2739529-A1; Synergistic fungicidal compsns., AU9672192-A; EP855859-A1; RHONE POULENC AGROCHIMIE (RHON) useful in controlling CN1198656-A; BR9611213-A; RHONE-POULENC AGROCHIMIE (RHON) phytopathogenic fungi in crops or JP11514993-W; MX9802657-A1; AVENTIS CROPSCIENCE SA (AVET) FR 1995 lawns - comprise strobilurin NZ319631-A; AU716143-B; US6057331-A; DUVERT P (DUVE-Individual) BAYER analogue and iprodione, KR99064025-A; IL123919-A; CROPSCIENCE SA (FARB) procymidone or vinchlozoline. US2003027720-A1; EP855859-B1; DE69626657-E; ES2188791-T3; MX210796-B Enhancing activity of agricultural WO9823157-A; EP944315-A; active products - such as growth WO9823157-A1; AU9714610-A; regulators, herbicides, fungicides EP944315-A1; CN1244771-A; NZ336424- MICRO FLO CO (MICR-Non-standard) WOUS 1996 or insecticides, using enhancer of A; BR9612796-A; MX9904920-A1; spores, cultures or suspensions US6232270-B1; AU738993-B; MX210622- of Bacillus or soil bacteria. B Synergistic fungicidal WO9846078-A; EP975217-A; compositions - comprising beta- AGROGENE LTD (AGRO-Non-standard) WO9846078-A1; ZA9803187-A; amino-butyric acid or its N- COHEN Y (COHE-Individual) KORAT M AU9868505-A; EP975217-A1; IL 1998 benzoyl-octyl ester, mixed with a (KORA-Individual) ZVI-TOV D (ZVIT- BR9808570-A; MX9909411-A1; fungicide, especially useful Individual) AU735925-B; US6414019-B1; IL123346- against fungi in potato, tomato, A; US2002193251-A1; EP975217-B1;

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PAÍS ANO TÍTULO DA PATENTE DEPOSITANTE NÚMERO DA PATENTE PRIOR. PRIOR. cucumber, melon, grape or DE69810761-E; US2003078290-A1; tobacco crops.. US2003078301-A1; ES2191295-T3; US6692774-B2 WO9849329-A; EP979295-A; DE19718251-A1; WO9849329-A1; AU9873356-A; ZA9803594-A; Production of fungicide-tolerant NO9905291-A; EP979295-A1; plants - by expression of BASF AG (BADI) CZ9903821-A3; SK9901372-A3; DE 1997 exogenous fungicide-binding BR9808698-A; CN1254381-A; NZ500181- polypeptide. A; HU200003594-A2; MX9909498-A1; AU737242-B; KR2001020387-A; JP2001523101-W WO9850422-A; EP981540-A; WO9850422-A1; AU9874767-A; NO9905462-A; EP981540-A1; New Bacillus subtilis strain BR9809282-A; CN1255143-A; AQ713 and its metabolites - SK9901490-A3; CZ9903757-A3; showing bactericidal, fungicidal AGRAQUEST INC (AGRA-Non-standard) US 1997 AU732724-B; NZ500506-A; MX9910078- and insecticidal activity, useful in A1; JP2001507237-W; HU200004555-A2; plant protection. KR2001012392-A; SK283036-B6; JP2003199558-A; JP3471815-B2; MX214455-B WO200013505-A; EP1104990-A; NOVARTIS AG (NOVS) NOVARTIS- EP1256277-A; EP1402777-A; Fungicidal mixture for protecting ERFINDUNGEN VERW GES MBH (NOVS) WO200013505-A2; AU9958587-A; crops, comprises (R)-metalaxyl SYNGENTA PARTICIPATIONS AG (SYNG- EP1104990-A2; BR9913459-A; GB 1998 and second fungicidal Non-standard) NUNINGER C (NUNI- US2001046492-A1; JP2002524396-W; component. Individual) WEISS M (WEIS-Individual) EP1256277-A1; MX2001002307-A1; LEADBEATER A J (LEAD-Individual) EP1402777-A1; EP1256277-B1; DE69919762-E; EP1104990-B1