DOCSLIB.ORG

Connecting to Country: an Australian Indigenous Metagenomics Strategy Environmental Scan and Research Gap Report

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Connecting to Country: an Australian Indigenous Metagenomics Strategy Environmental Scan and Research Gap Report Connecting to Country: An Australian Indigenous Metagenomics Strategy Environmental Scan and Research Gap Report December 2020 © Commonwealth of Australia as represented by the Department of Health 2021 Creative Commons Licence This publication is licensed under the Creative Commons Attribution 4.0 International Public License available from https://creativecommons.org/licenses/by/4.0/legalcode (“Licence”). You must read and understand the Licence before using any material from this publication. Restrictions The Licence may not give you all the permissions necessary for your intended use. For example, other rights (such as publicity, privacy and moral rights) may limit how you use the material found in this publication. The Licence does not cover, and there is no permission given for, use of any of the images, diagrams or maps found in this publication. Attribution Without limiting your obligations under the Licence, the Department of Health requests that you attribute this publication in your work. Any reasonable form of words may be used provided that you: • include a reference to this publication and where, practicable, the relevant page numbers; • make it clear that you have permission to use the material under the Creative Commons Attribution 4.0 International Public License; • make it clear whether or not you have changed the material used from this publication; • include a copyright notice in relation to the material used. In the case of no change to the material, the words “© Commonwealth of Australia (Department of Health) 2021” may be used. In the case where the material has been changed or adapted, the words: “Based on Commonwealth of Australia (Department of Health) material” may be used; and • do not suggest that the Department of Health endorses you or your use of the material. Enquiries Enquiries regarding any other use of this publication should be addressed to the Branch Manager, Communication Branch, Department of Health, GPO Box 9848, Canberra ACT 2601, or via e-mail to [email protected] Authors: Professor Kerry Arabena, Chris Holland and Lauren Penny Managing editor: Jane Yule @ Brevity Comms Editor: Cathy Edmonds For citation: Arabena, K., Holland, C. & Penny, L. 2020, Connecting to Country: An Australian Indigenous Metagenomics Strategy, Environmental Scan and Research Gap Report, Karabena Consulting, Melbourne. A note on terminology: Throughout this report, the terms ‘Aboriginal and Torres Strait Islander’ or ‘Indigenous’ are generally used when referring to the First Nations’ peoples of Australia. Professional disclosure statement: This report was completed by Karabena Consulting for the consideration of the Aboriginal and Torres Strait Islander Advisory Group on Genomics. It has been prepared in good faith based on the research and information available to Karabena Consulting at the date of publication without any independent verification, and may not be accurate, complete or up to date. Before using any part of this report, users must obtain independent professional advice to determine the suitability of the content of this report for their intended use. ii Contents Preface ...................................................................................................................................... vii Summary .................................................................................................................................... xi Why do we need an Australian Indigenous Metagenomics Strategy? .............................................. xi Environmental scan ........................................................................................................................... xii Gap analysis report ............................................................................................................................ xii Recommendations............................................................................................................................ xiii 1 Introduction ............................................................................................................................ 1 Post-2010 scope of the environmental scan and gap analysis report ................................................2 What is metagenomics and how can it help to close the gap?...........................................................2 A call for Indigenous leadership in metagenomics ............................................................................4 A note on terminology ........................................................................................................................5 2 Background: metagenomics within whole ecologies ................................................................. 6 Theoretical approaches to develop a metagenomics strategy linked to whole ecologies .................7 Recognising that Indigenous and non-Indigenous worldviews are different .....................................7 Australian Indigenous science ....................................................................................................8 Multidimensional worldviews ....................................................................................................9 Eco-patterning and lived experiences ..................................................................................... 10 Transitioning from monocultured actions to stewardship in genetic research agenda setting ...... 11 Locating Indigenous metagenomic research: a ‘best of both worlds’ approach ............................. 12 Best of both worlds: cultural, social and emotional wellbeing research strategies................ 13 Best of both worlds: sustainability, stewardship and the threat to ecological communities . 14 Best of both worlds: trauma and epigenetic healing .............................................................. 17 Best of both worlds: a cardiometabolic healing research agenda .......................................... 18 Best of both worlds: seeking sustainable relationships .......................................................... 19 The intention of the Australian Indigenous Metagenomics Strategy .............................................. 20 3 Methods and methodology ................................................................................................... 21 Environmental scan .......................................................................................................................... 21 Gap analysis report ........................................................................................................................... 22 Literature review .............................................................................................................................. 22 Search strategy inclusions and exclusions ............................................................................... 22 Stakeholder interviews ..................................................................................................................... 23 4 Environmental scan ............................................................................................................... 24 Research initiatives focusing on Australian Indigenous people’s health genomics ........................ 24 Australian heritage: constructing the first Aboriginal reference genome .............................. 25 Better Indigenous Genetic (BIG) Health Services .................................................................... 25 Population Variation Project.................................................................................................... 26 iii Aboriginal and Torres Strait Islander Genome Project ............................................................ 26 Trails of migration out of Africa in harmful mutations of the First Peoples ........................... 27 Adaptation and diversification of the First Peoples of Sahul .................................................. 27 Genetic variants introduced by Europeans and other groups into the genomes of the Aboriginal Australian population ............................................................................................. 27 Aboriginal Heritage Project ...................................................................................................... 27 Investigating the evolution of innate and adaptive cellular immunity ................................... 28 Additional research projects influencing Australian Indigenous genomic initiatives ............. 28 Summary of key points ............................................................................................................ 30 Research projects that are being, or could be, translated to enhance clinical genomics services . 30 Achieving equity in genomic health for Indigenous Australians ............................................. 31 Genomic architecture of chronic disease in Australia’s First Peoples ..................................... 31 Understanding and overcoming cardiovascular and diabetes inequalities in Indigenous Australians ............................................................................................................................... 32 Our MOB (Our Mind Our Brain) dementia prevention across the life course with Aboriginal Australians .............................................................................................................. 32 Translating molecular research into clinical applications to control scabies .......................... 32 Contribution of carbohydrate
Load more

Recommended publications
  • Sedimentary Biomarkers Reaffirm Human Impacts on Northern Beringian Ecosystems During the Last Glacial Period
    bs_bs_banner Sedimentary biomarkers reaffirm human impacts on northern Beringian ecosystems during the Last Glacial period RICHARD S. VACHULA , YONGSONG HUANG, JAMES M. RUSSELL, MARK B. ABBOTT, MATTHEW S. FINKENBINDER AND JONATHAN A. O’DONNELL Vachula, R. S., Huang, Y. , Russell, J. M., Abbott, M. B., Finkenbinder, M. S. & O’Donnell, J. A.: Sedimentary biomarkers reaffirm human impacts on northern Beringian ecosystems during the Last Glacial period. Boreas. https://doi.org/10.1111/bor.12449. ISSN 0300-9483. Our understanding of the timing of human arrival to the Americas remains fragmented, despite decades of active research and debate. Genetic research has recently led to the ‘Beringian standstill hypothesis’ (BSH), which suggests an isolated group of humans lived somewhere in Beringia for millennia during the Last Glacial, before a subgroup migrated southward into the American continents about 14 ka. Recently published organic geochemical data suggest human presence around Lake E5 on the Alaskan North Slope during the Last Glacial; however, these biomarker proxies, namely faecal sterols and polycyclic aromatic hydrocarbons (PAHs), are relatively novel and require replication to bolster their support of the BSH. Wepresent newanalyses of thesebiomarkers in the sediment archive of Burial Lake (latitude 68°260N, longitude 159°100W m a.s.l.) in northwestern Alaska. Our analyses corroborate that humans were present in Beringia during the Last Glacial and that they likely promoted fire activity. Our data also suggest that humans coexistedwith Ice Age megafauna for millenniaprior to theireventual extinction at the end of the Last Glacial. Lastly, we identify fire as an overlooked ecological component of the mammoth steppe ecosystem.
    [Show full text]
  • The Population History of Northeastern Siberia Since the Pleistocene Martin Sikora1,43*, Vladimir V
    ARTICLE https://doi.org/10.1038/s41586-019-1279-z The population history of northeastern Siberia since the Pleistocene Martin Sikora1,43*, Vladimir V. Pitulko2,43*, Vitor C. Sousa3,4,5,43, Morten E. Allentoft1,43, Lasse Vinner1, Simon Rasmussen6,41, Ashot Margaryan1, Peter de Barros Damgaard1, Constanza de la Fuente1,42, Gabriel Renaud1, Melinda A. Yang7, Qiaomei Fu7, Isabelle Dupanloup8, Konstantinos Giampoudakis9, David Nogués-Bravo9, Carsten Rahbek9, Guus Kroonen10,11, Michaël Peyrot11, Hugh McColl1, Sergey V. Vasilyev12, Elizaveta Veselovskaya12,13, Margarita Gerasimova12, Elena Y. Pavlova2,14, Vyacheslav G. Chasnyk15, Pavel A. Nikolskiy2,16, Andrei V. Gromov17, Valeriy I. Khartanovich17, Vyacheslav Moiseyev17, Pavel S. Grebenyuk18,19, Alexander Yu. Fedorchenko20, Alexander I. Lebedintsev18, Sergey B. Slobodin18, Boris A. Malyarchuk21, Rui Martiniano22, Morten Meldgaard1,23, Laura Arppe24, Jukka U. Palo25,26, Tarja Sundell27,28, Kristiina Mannermaa27, Mikko Putkonen25, Verner Alexandersen29, Charlotte Primeau29, Nurbol Baimukhanov30, Ripan S. Malhi31,32, Karl-Göran Sjögren33, Kristian Kristiansen33, Anna Wessman27,34, Antti Sajantila25, Marta Mirazon Lahr1,35, Richard Durbin22,36, Rasmus Nielsen1,37, David J. Meltzer1,38, Laurent Excoffier4,5* & Eske Willerslev1,36,39,40* Northeastern Siberia has been inhabited by humans for more than 40,000 years but its deep population history remains poorly understood. Here we investigate the late Pleistocene population history of northeastern Siberia through analyses of 34 newly recovered ancient
    [Show full text]
  • Beringian Paleoecology: Results from the 1997 Workshop Scott A
    Quaternary Science Reviews 20 (2001) 7}13 Beringian paleoecology: results from the 1997 workshop Scott A. Elias* Institute of Arctic and Alpine Research, University of Colorado 1560, 30th Street, Campus Box 450, Boulder, CO, 80309-0450, USA Abstract Much progress has been made in the various "elds concerned with Beringian studies since the publication of Paleoecology of Beringia in 1982. The 1997 Beringian Paleoenvironments workshop brought together Russian, Canadian, and American scientists, and the paleoecological and archaeological presentations gave rise to 20 papers. The main points of most of these papers are summarized here, in the context of speci"c research topics, including (1) timing and environments associated with the Old Crow tephra in Eastern Beringia; (2) Last Interglacial environments of Eastern Beringia; (3) interstadial environments from the middle of the Last Glaciation in Beringia; (4) full glacial environments in Beringia; (5) Lateglacial environments in Beringia; (6) early Holocene environments in Beringia; (7) Late Pleistocene archaeology of Siberia; and 8) the timing, adaptations, and possible migration routes of people entering the New World. ( 2000 Elsevier Science Ltd. All rights reserved. 1. Introduction Our joint "eld of Beringian research has bene"tted greatly from the cessation of that undeclared war. Many The "rst book on Beringian paleoenvironments was scientists now travel back and forth between the US and The Bering Land Bridge, published in 1967 (Hopkins, Russia to visit "eld sites, collaborate on joint research 1967). The volume entitled Paleoecology of Beringia, pub- projects, and attend meetings. Attendees at the 1997 lished in 1982 broke considerable new ground in this "eld workshop presented new contributions on paleoenviron- Hopkins et al.
    [Show full text]
  • Terminal Pleistocene Alaskan Genome Reveals First Founding Population of Native Americans J
    LETTER doi:10.1038/nature25173 Terminal Pleistocene Alaskan genome reveals first founding population of Native Americans J. Víctor Moreno-Mayar1*, Ben A. Potter2*, Lasse Vinner1*, Matthias Steinrücken3,4, Simon Rasmussen5, Jonathan Terhorst6,7, John A. Kamm6,8, Anders Albrechtsen9, Anna-Sapfo Malaspinas1,10,11, Martin Sikora1, Joshua D. Reuther2, Joel D. Irish12, Ripan S. Malhi13,14, Ludovic Orlando1, Yun S. Song6,15,16, Rasmus Nielsen1,6,17, David J. Meltzer1,18 & Eske Willerslev1,8,19 Despite broad agreement that the Americas were initially populated Native American ancestors were isolated from Asian groups in Beringia via Beringia, the land bridge that connected far northeast Asia before entering the Americas2,9,13; whether one or more early migra- with northwestern North America during the Pleistocene epoch, tions gave rise to the founding population of Native Americans1–4,7,14 when and how the peopling of the Americas occurred remains (it is commonly agreed that the Palaeo-Eskimos and Inuit populations unresolved1–5. Analyses of human remains from Late Pleistocene represent separate and later migrations1,15,16); and when and where Alaska are important to resolving the timing and dispersal of these the basal split between southern and northern Native American (SNA populations. The remains of two infants were recovered at Upward and NNA, respectively) branches occurred. It also remains unresolved Sun River (USR), and have been dated to around 11.5 thousand whether the genetic affinity between some SNA groups and indigenous years ago (ka)6. Here, by sequencing the USR1 genome to an average Australasians2,3 reflects migration by non-Native Americans3,4,14, early coverage of approximately 17 times, we show that USR1 is most population structure within the first Americans3 or later gene flow2.
    [Show full text]
  • Haplogroup a Sample Report
    1 Genelex Laboratory #:20470-11 Participant: Jane Doe Summary of Findings: The results of the mtDNA sequencing test for Jane Doe found differences with the Cambridge Reference Sequence at positions 16111, 16187, 16223, 16290, 16319, 16362, 64, 73, 146, 153, 235, and 263. The bases found at these positions are listed on your certificate. Results: The mtDNA signature may be used to identify an individual and their direct maternal lineage. The mtDNA signature may also be helpful in identifying ethnic origins. Portions of the hypervariable region I and II from the mtDNA were amplified and sequenced from base pair positions 16100-16569 and 1-290 respectively. The mtDNA sequence data was compared to the Cambridge Reference Sequence. Any differences from the Cambridge Reference Sequence outside of the stated region will not be detected by using this test. This information was then referenced with current mtDNA haplogroup and archaeological information sources to provide a description of the origins of the maternal line. Haplogroup Assignment: A Haplogroup Description: You belong to Haplogroup A, a lineage originating in North East Siberia in the ancient Chukotkan populations (Chukchi and Siberian Eskimos). Your ancestral clan spread to the Americas and now represents over 40% of Native American populations. According to genetic theory, all humans descend from a woman nicknamed "African Eve." This unknown woman probably lived in Africa, perhaps in Kenya, about 145,000 years ago (~5,700 generations). She was a very distant cousin of the Neanderthals, but unlike them, she became an ancestor of all modern humans. She wasn't the only human female in her generation -- some scientists think that she belonged to a human population of about 2,000 people.
    [Show full text]
  • The Population History of Northeastern Siberia Since the Pleistocene
    bioRxiv preprint doi: https://doi.org/10.1101/448829; this version posted October 22, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. The population history of northeastern Siberia since the Pleistocene Martin Sikora1,*, Vladimir V. Pitulko2,*, Vitor C. Sousa3,4,5,*, Morten E. Allentoft1,*, Lasse Vinner1, Simon Rasmussen6, Ashot Margaryan1, Peter de Barros Damgaard1, Constanza de la Fuente Castro1, Gabriel Renaud1, Melinda Yang7, Qiaomei Fu7, Isabelle Dupanloup8, Konstantinos Giampoudakis9, David Bravo Nogues9, Carsten Rahbek9, Guus Kroonen10,11, Michäel Peyrot11, Hugh McColl1, Sergey V. Vasilyev12, Elizaveta Veselovskaya12,13, Margarita Gerasimova12, Elena Y. Pavlova2,14, Vyacheslav G. Chasnyk15, Pavel A. Nikolskiy2,16, Pavel S. Grebenyuk17,18, Alexander Yu. Fedorchenko19, Alexander I. Lebedintsev17, Sergey B. Slobodin17, Boris A. Malyarchuk20, Rui Martiniano21,22, Morten Meldgaard1,23, Laura Arppe24, Jukka U. Palo25,26, Tarja Sundell27,28, Kristiina Mannermaa27, Mikko Putkonen25, Verner Alexandersen29, Charlotte Primeau29, Ripan Mahli30,31, Karl- Göran Sjögren32, Kristian Kristiansen32, Anna Wessman27, Antti Sajantila25, Marta Mirazon Lahr1,33, Richard Durbin21,22, Rasmus Nielsen1,34, David J. Meltzer1,35, Laurent Excoffier4,5, Eske Willerslev1,22,36** 1 - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5–7, 1350 Copenhagen, Denmark. 2 - Palaeolithic Department, Institute for the History of Material Culture RAS, 18 Dvortsovaya nab., 191186 St. Petersburg, Russia. 3 - Centre for Ecology, Evolution and Environmental Changes, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.
    [Show full text]
  • 1 Ancient Genomes Reveal Long Range Influence of the Site and Culture of Tiwanaku
    Supplementary Information for Ancient genomes reveal long range influence of the site and culture of Tiwanaku Danijela Popović1*, Martyna Molak1,2, Mariusz Ziołkowski3, Alexei Vranich4, Maciej Sobczyk3, Delfor Ulloa Vidaurre5, Magdalena Skrzypczak1, Krzysztof Ginalski1, Guido Agresti3, Thiseas Christos Lamnidis6, Nathan Nakatsuka7,8, Swapan Mallick7,9,10, Mateusz Baca1* 1 Centre of New Technologies, University of Warsaw, S. Banacha 2c, 02-097 Warsaw, Poland 2 Museum and Institute of Zoology, Polish Academy of Sciences, Wilcza 64, 00-679 Warsaw, Poland 3 Centre for Andean Studies, University of Warsaw, Krakowskie Przedmieście 26/28, 00-927 Warsaw, Poland 4 Department of Anthropology, University of Texas, San Antonio. College of Liberal and Fine Arts. One UTSA Circle San Antonio, TX 78249-1644 5 Unit of Archeology and Museums - Vice-Ministry of Interculturality. Tiahuanaco Street No93 at the corner of Federico Suazo. Box 4856. La Paz, Bolivia 6 Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Kahlaische Straße 10, 07745 Jena, Germany 7 Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA 8 Harvard-MIT Division of Health Sciences and Technology, Boston, MA 02115, USA 9 Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02446, USA 10Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA *corresponding authors: * Danijela Popović; Mateusz Baca Email: [email protected]; [email protected] This PDF file includes: Supplementary Information Text Figures S1 to S3 Other supplementary materials for this manuscript include the following: Datasets S1 to S3 Supplementary Information Text 1.ARCHAEOLOGICAL SITE INFORMATION Bolivia Samples from individuals from Bolivia were obtained under permission from La Unidad de Arqueologia y Museos (UDAM) Ministerio de Culturas y Turismo no.
    [Show full text]
  • Ancient DNA Studies in Pre-Columbian Mesoamerica
    G C A T T A C G G C A T genes Review Ancient DNA Studies in Pre-Columbian Mesoamerica Xavier Roca-Rada 1,* , Yassine Souilmi 1,2,3 , João C. Teixeira 1,4 and Bastien Llamas 1,2,3,4,* 1 Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia; [email protected] (Y.S.); [email protected] (J.C.T.) 2 National Centre for Indigenous Genomics, Australian National University, Canberra, ACT 0200, Australia 3 Environment Institute, University of Adelaide, Adelaide, SA 5005, Australia 4 Centre of Excellence for Australian Biodiversity and Heritage (CABAH), School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia * Correspondence: [email protected] (X.R.-R.); [email protected] (B.L.); Tel.: +61-8-8313-0262 (X.R.-R. & B.L.) Received: 1 October 2020; Accepted: 10 November 2020; Published: 13 November 2020 Abstract: Mesoamerica is a historically and culturally defined geographic area comprising current central and south Mexico, Belize, Guatemala, El Salvador, and border regions of Honduras, western Nicaragua, and northwestern Costa Rica. The permanent settling of Mesoamerica was accompanied by the development of agriculture and pottery manufacturing (2500 BCE–150 CE), which led to the rise of several cultures connected by commerce and farming. Hence, Mesoamericans probably carried an invaluable genetic diversity partly lost during the Spanish conquest and the subsequent colonial period. Mesoamerican ancient DNA (aDNA) research has mainly focused on the study of mitochondrial DNA in the Basin of Mexico and the Yucatán Peninsula and its nearby territories, particularly during the Postclassic period (900–1519 CE).
    [Show full text]
  • Recent Excavations at Owl Ridge, Interior Alaska
    Received: 15 February 2019 | Revised: 24 May 2019 | Accepted: 29 May 2019 DOI: 10.1002/gea.21754 RESEARCH ARTICLE Recent excavations at Owl Ridge, interior Alaska: Site stratigraphy, chronology, and site formation and implications for late Pleistocene archaeology and peopling of eastern Beringia Kelly E. Graf1 | Angela K. Gore1 | J. Anne Melton2 | Tarah Marks3 | Lyndsay DiPietro4 | Ted Goebel1 | Michael R. Waters1 | David Rhode5 1Center for the Study of the First Americans, Department of Anthropology, Texas A&M Abstract University, College Station, Texas The early archaeological record of Beringia is complicated by the occurrence of 2Department of Anthropology, University of several lithic industries. Site assemblages, dating from 14,000 to 12,800 years ago Minnesota, Minneapolis, Minnesota ‐ 3Department of Anthropology, University of and located from the Yana Indigirka Lowlands of Siberia to the upper Tanana River Iowa, Iowa City, Iowa basin, contain artifacts characteristic of the Nenana technological complex. After 4 Department of Geology, Baylor University, 12,800 years ago, site assemblages contain artifacts diagnostic of the Denali Waco, Texas 5Division of Earth and Ecosystem Sciences, technocomplex. To explain the variation in lithic industries, we first and foremost Desert Research Institute, Reno, Nevada need well‐stratified and well‐dated sites with multiple components so we securely Correspondence know their ages and depositional relationships. We present excavation results of one Kelly E. Graf, Center for the Study of the First such site located in interior Alaska, Owl Ridge, with the goal of assessing site Americans, Department of Anthropology, Texas A&M University, College Station, stratigraphy, radiocarbon chronology, and natural site formation processes.
    [Show full text]
  • Early Human Dispersals Within the Americas
    RESEARCH ARTICLES Cite as: J. V. Moreno-Mayar et al., Science 10.1126/science.aav2621 (2018). Early human dispersals within the Americas J. Víctor Moreno-Mayar1*, Lasse Vinner1*, Peter de Barros Damgaard1*, Constanza de la Fuente1*, Jeffrey Chan2*, Jeffrey P. Spence3*, Morten E. Allentoft1, Tharsika Vimala1, Fernando Racimo1, Thomaz Pinotti4, Simon Rasmussen5, Ashot Margaryan1,6, Miren Iraeta Orbegozo1, Dorothea Mylopotamitaki1, Matthew Wooller7, Clement Bataille8, Lorena Becerra-Valdivia9, David Chivall9, Daniel Comeskey9, Thibaut Devièse9, Donald K. Grayson10, Len George11, Harold Harry12, Verner Alexandersen13, Charlotte Primeau13, Jon Erlandson14, Claudia Rodrigues-Carvalho15, Silvia Reis15, Murilo Q. R. Bastos15, Jerome Cybulski16,17,18, Carlos Vullo19, Flavia Morello20, Miguel Vilar21, Spencer Wells22, Kristian Gregersen1, Kasper Lykke Hansen1, Niels Lynnerup13, Marta Mirazón Lahr23, Kurt Kjær1, André Strauss24,25, Marta Alfonso-Durruty26, Antonio Salas27,28, Hannes Schroeder1, Thomas Higham9, Ripan S. Malhi29, Jeffrey T. Rasic30, Luiz Souza31, Fabricio R. Santos4, Anna-Sapfo Malaspinas32, Martin Sikora1, Rasmus Nielsen1,33,34, Yun S. Song2,33,35†, David J. Meltzer1,36†, Eske Willerslev1,37,38† Downloaded from 1Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen, Denmark. 2Computer Science Division, University of California, Berkeley, CA 94720, USA. 3Computational Biology Graduate Group, University of California, Berkeley, CA 94720, USA. 4Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. 5Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark. 6Institute of Molecular Biology, National Academy of Sciences, 7 Hasratian St., 0014, Yerevan, Armenia. 7Alaska Stable Isotope Facility, Water and Environmental Research Center, University of Alaska Fairbanks, Fairbanks, AK 99775, USA.
    [Show full text]
  • Terminal Pleistocene Alaskan Genome Reveals First Founding Population of Native 2 Americans 3 4 J
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by LJMU Research Online 1 Terminal Pleistocene Alaskan genome reveals first founding population of Native 2 Americans 3 4 J. Víctor Moreno-Mayar 1,*, Ben A. Potter 2,*, Lasse Vinner 1,* Matthias Steinrücken 5 3,4,5, Simon Rasmussen 6, Jonathan Terhorst 4, John A. Kamm4,7, Anders 6 Albrechtsen 8, Anna-Sapfo Malaspinas 1,9,10, Martin Sikora 1, Joshua D. Reuther2, 7 Joel D. Irish11, Ripan S. Malhi 12,13, Ludovic Orlando 1, Yun S. Song 3,4,14,15, Rasmus 8 Nielsen 1,4,14, David J. Meltzer 1,16 and Eske Willerslev 1,7,17,**. 9 10 1. Centre for GeoGenetics, Natural History Museum of Denmark, University of 11 Copenhagen, 1350 Copenhagen, Denmark. 12 2. Department of Anthropology, University of Alaska, Fairbanks, AK 99775. 13 3. Computer Science Division, University of California, Berkeley, CA 94720, USA. 14 4. Department of Statistics, University of California, Berkeley, CA 94720, USA. 15 5. Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, 16 MA 01003, USA. 17 6. Center for Biological Sequence Analysis, Department of Systems Biology, Technical 18 University of Denmark, 2800 Kongens Lyngby, Denmark. 19 7. Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, 20 CB10 1SA, UK. 21 8. The Bioinformatics Centre, Department of Biology, University of Copenhagen, 2200 22 Copenhagen, Denmark. 23 9. Institute of Ecology and Evolution, University of Bern, CH-3012 Bern, Switzerland. 24 10. Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland. 25 11. Research Centre in Evolutionary Anthropology and Palaeoecology, Liverpool John 26 Moores University, Liverpool L3 3AF, UK.
    [Show full text]
  • Peopling of the Americas As Inferred from Ancient Genomics
    Review Peopling of the Americas as inferred from ancient genomics https://doi.org/10.1038/s41586-021-03499-y Eske Willerslev1,2,3,5 ✉ & David J. Meltzer2,4,5 ✉ Received: 9 November 2020 Accepted: 26 March 2021 In less than a decade, analyses of ancient genomes have transformed our Published online: xx xx xxxx understanding of the Indigenous peopling and population history of the Americas. These studies have shown that this history, which began in the late Pleistocene epoch Check for updates and continued episodically into the Holocene epoch, was far more complex than previously thought. It is now evident that the initial dispersal involved the movement from northeast Asia of distinct and previously unknown populations, including some for whom there are no currently known descendants. The frst peoples, once south of the continental ice sheets, spread widely, expanded rapidly and branched into multiple populations. Their descendants—over the next ffteen millennia— experienced varying degrees of isolation, admixture, continuity and replacement, and their genomes help to illuminate the relationships among major subgroups of Native American populations. Notably, all ancient individuals in the Americas, save for later-arriving Arctic peoples, are more closely related to contemporary Indigenous American individuals than to any other population elsewhere, which challenges the claim—which is based on anatomical evidence—that there was an early, non-Native American population in the Americas. Here we review the patterns revealed by ancient genomics that help to shed light on the past peoples who created the archaeological landscape, and together lead to deeper insights into the population and cultural history of the Americas.
    [Show full text]