Paleontology the MUSEUM’S SCIENCE WEB SITE for KIDS
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A Comprehensive Framework to Reinforce Evidence Synthesis Features in Cloud-Based Systematic Review Tools
applied sciences Article A Comprehensive Framework to Reinforce Evidence Synthesis Features in Cloud-Based Systematic Review Tools Tatiana Person 1,* , Iván Ruiz-Rube 1 , José Miguel Mota 1 , Manuel Jesús Cobo 1 , Alexey Tselykh 2 and Juan Manuel Dodero 1 1 Department of Informatics Engineering, University of Cadiz, 11519 Puerto Real, Spain; [email protected] (I.R.-R.); [email protected] (J.M.M.); [email protected] (M.J.C.); [email protected] (J.M.D.) 2 Department of Information and Analytical Security Systems, Institute of Computer Technologies and Information Security, Southern Federal University, 347922 Taganrog, Russia; [email protected] * Correspondence: [email protected] Abstract: Systematic reviews are powerful methods used to determine the state-of-the-art in a given field from existing studies and literature. They are critical but time-consuming in research and decision making for various disciplines. When conducting a review, a large volume of data is usually generated from relevant studies. Computer-based tools are often used to manage such data and to support the systematic review process. This paper describes a comprehensive analysis to gather the required features of a systematic review tool, in order to support the complete evidence synthesis process. We propose a framework, elaborated by consulting experts in different knowledge areas, to evaluate significant features and thus reinforce existing tool capabilities. The framework will be used to enhance the currently available functionality of CloudSERA, a cloud-based systematic review Citation: Person, T.; Ruiz-Rube, I.; Mota, J.M.; Cobo, M.J.; Tselykh, A.; tool focused on Computer Science, to implement evidence-based systematic review processes in Dodero, J.M. -
Molecular Biology for Computer Scientists
CHAPTER 1 Molecular Biology for Computer Scientists Lawrence Hunter “Computers are to biology what mathematics is to physics.” — Harold Morowitz One of the major challenges for computer scientists who wish to work in the domain of molecular biology is becoming conversant with the daunting intri- cacies of existing biological knowledge and its extensive technical vocabu- lary. Questions about the origin, function, and structure of living systems have been pursued by nearly all cultures throughout history, and the work of the last two generations has been particularly fruitful. The knowledge of liv- ing systems resulting from this research is far too detailed and complex for any one human to comprehend. An entire scientific career can be based in the study of a single biomolecule. Nevertheless, in the following pages, I attempt to provide enough background for a computer scientist to understand much of the biology discussed in this book. This chapter provides the briefest of overviews; I can only begin to convey the depth, variety, complexity and stunning beauty of the universe of living things. Much of what follows is not about molecular biology per se. In order to 2ARTIFICIAL INTELLIGENCE & MOLECULAR BIOLOGY explain what the molecules are doing, it is often necessary to use concepts involving, for example, cells, embryological development, or evolution. Bi- ology is frustratingly holistic. Events at one level can effect and be affected by events at very different levels of scale or time. Digesting a survey of the basic background material is a prerequisite for understanding the significance of the molecular biology that is described elsewhere in the book. -
Outline of Science
Outline of science The following outline is provided as a topical overview of • Empirical method – science: • Experimental method – The steps involved in order Science – systematic effort of acquiring knowledge— to produce a reliable and logical conclusion include: through observation and experimentation coupled with logic and reasoning to find out what can be proved or 1. Asking a question about a natural phenomenon not proved—and the knowledge thus acquired. The word 2. Making observations of the phenomenon “science” comes from the Latin word “scientia” mean- 3. Forming a hypothesis – proposed explanation ing knowledge. A practitioner of science is called a for a phenomenon. For a hypothesis to be a "scientist". Modern science respects objective logical rea- scientific hypothesis, the scientific method re- soning, and follows a set of core procedures or rules in or- quires that one can test it. Scientists generally der to determine the nature and underlying natural laws of base scientific hypotheses on previous obser- the universe and everything in it. Some scientists do not vations that cannot satisfactorily be explained know of the rules themselves, but follow them through with the available scientific theories. research policies. These procedures are known as the 4. Predicting a logical consequence of the hy- scientific method. pothesis 5. Testing the hypothesis through an experiment – methodical procedure carried out with the 1 Essence of science goal of verifying, falsifying, or establishing the validity of a hypothesis. The 3 types of -
Principal Scientist, Pharmacology (DMPK) at Entrada Therapeutics Full-Time Opportunity in Boston, MA
Principal Scientist, Pharmacology (DMPK) at Entrada Therapeutics Full-Time Opportunity in Boston, MA Company Overview Entrada Therapeutics is a biotechnology company dedicated to transforming the treatment of devastating diseases through the intracellular delivery of biologics. Entrada’s technology enables the efficient intracellular delivery of proteins, peptides and nucleic acids, thus allowing for the development of programs across several intracellular target classes. The Company’s novel approach addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the delivery of molecules into the cytosol. Entrada is comprised of experts and leaders in both biologics development and the rare disease space. In December 2018, Entrada closed a $59 million Series A from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital. Position Summary Entrada is hiring for a highly motivated, collaborative and innovative Principal Scientist, specializing in pharmacokinetics and pharmacology to join the Company’s intracellular biologics discovery and development efforts. The candidate will work with a world-class, multidisciplinary team of drug discovery scientists and lead the in vitro and in vivo ADME, PK, PD and toxicokinetic efforts. Specifically, the candidate will design, manage and execute in vitro and in vivo programs both in- house and at contract research organizations. The candidate will also be responsible for analyzing, interpreting and modeling -
How Science Works
PB 1 How science works The Scientific Method is traditionally presented in the first chapter of science text- books as a simple recipe for performing scientific investigations. Though many use- ful points are embodied in this method, it can easily be misinterpreted as linear and “cookbook”: pull a problem off the shelf, throw in an observation, mix in a few ques- tions, sprinkle on a hypothesis, put the whole mixture into a 350° experiment—and voila, 50 minutes later you’ll be pulling a conclusion out of the oven! That might work if science were like Hamburger Helper®, but science is complex and cannot be re- duced to a single, prepackaged recipe. The linear, stepwise representation of the process of science is simplified, but it does get at least one thing right. It captures the core logic of science: testing ideas with evidence. However, this version of the scientific method is so simplified and rigid that it fails to accurately portray how real science works. It more accurately describes how science is summarized after the fact—in textbooks and journal articles—than how sci- ence is actually done. The simplified, linear scientific method implies that scientific studies follow an unvarying, linear recipe. But in reality, in their work, scientists engage in many different activities in many different sequences. Scientific investigations often involve repeating the same steps many times to account for new information and ideas. The simplified, linear scientific method implies that science is done by individual scientists working through these steps in isolation. But in reality, science depends on interactions within the scientific community. -
Rowan C. Martindale Curriculum Vitae Associate Professor (Invertebrate Paleontology) at the University of Texas at Austin
ROWAN C. MARTINDALE CURRICULUM VITAE ASSOCIATE PROFESSOR (INVERTEBRATE PALEONTOLOGY) AT THE UNIVERSITY OF TEXAS AT AUSTIN Department of Geological Sciences E-mail: [email protected] Jackson School of Geosciences Website: www.jsg.utexas.edu/martindale/ 2275 Speedway Stop C9000 Orchid ID: 0000-0003-2681-083X Austin, TX 78712-1722 Phone: 512-475-6439 Office: JSG 3.216A RESEARCH INTERESTS The overarching theme of my work is the connection between Earth and life through time, more precisely, understanding ancient (Mesozoic and Cenozoic) ocean ecosystems and the evolutionary and environmental events that shaped them. My research is interdisciplinary, (paleontology, sedimentology, biology, geochemistry, and oceanography) and focuses on: extinctions and carbon cycle perturbation events (e.g., Oceanic Anoxic Events, acidification events); marine (paleo)ecology and reef systems; the evolution of reef builders (e.g., coral photosymbiosis); and exceptionally preserved fossil deposits (Lagerstätten). ACADEMIC APPOINTMENTS Associate Professor, University of Texas at Austin September 2020 to Present Assistant Professor, University of Texas at Austin August 2014 to August 2020 Postdoctoral Researcher, Harvard University August 2012 to July 2014 Department of Organismic and Evolutionary Biology; Mentor: Dr. Andrew H. Knoll. EDUCATION Doctorate, University of Southern California 2007 to 2012 Dissertation: “Paleoecology of Upper Triassic reef ecosystems and their demise at the Triassic-Jurassic extinction, a potential ocean acidification event”. Advisor: Dr. David J. Bottjer, degree conferred August 7th, 2012. Bachelor of Science Honors Degree, Queen’s University 2003 to 2007 Geology major with a general concentration in Biology (Geological Sciences Medal Winner). AWARDS AND RECOGNITION Awards During Tenure at UT Austin • 2019 National Science Foundation CAREER Award: Awarded to candidates who are judged to have the potential to serve as academic role models in research and education. -
Some Philosophical Questions About Paleontology and Their Practica1 Consequences
ACTA GEOLOGICA HISPANICA. Concept and method in Paleontology. 16 (1981) nos 1-2, pags. 7-23 Some philosophical questions about paleontology and their practica1 consequences by Miquel DE RENZI Depto. de Geología, Facultad de Ciencias Biológicas, Universidad de Valencia. Burjassot (Valencia). This papcr attempts to objectively discuss the actual state ofpaleontology. The En aquest treball s'ha intentat fer un balanc d'alguns aspectes de I'estat de la progress of this science stood still somewhat during the latter part of the last paleontologia. La historia de la paleontologia mostra un estancarnent a les century which caused it to develop apart from the biological sciences. an area to darreries del segle passac aquest estancament va Fer que la nostra ciencia s'anes which it is naturally tied. As aconsequence, this bruought a long-term stagnation, allunyant cada cop mes de I'area de les ciencies bii~logiques,amb les qualsestava because biology, dunng this century, has made great progress and paleontology lligada naturalment AixO va portar, com a conseqüencia, un important has not During the last 20 years paleontology as a science hasrecuperatedsome endarreriment, car la biologia, durant aquest segle, ha donat un gran pas of this loss, but we as scientists need to be careful in various aspects of its endavant, mentre que aquest no ha estat el cas de lapaleontologia Al nostre pais development -i possiblement a molts d'altres- la paleontologia es, fonamentalment, un estn per datar estrats. Tanmateix, un mal estri, car la datació es basadaen les especies fossils i la seva determinació es fonamenta en el ccncepte d'especie biolbgica; els fossils pero en moltes ocasions, són utilitzats mes aviat com si fossin segells o monedes. -
Internationalizing the University Curricula Through Communication
DOCUMENT RESUME ED 428 409 CS 510 027 AUTHOR Oseguera, A. Anthony Lopez TITLE Internationalizing the University Curricula through Communication: A Comparative Analysis among Nation States as Matrix for the Promulgation of Internationalism, through the Theoretical Influence of Communication Rhetors and International Educators, Viewed within the Arena of Political-Economy. PUB DATE 1998-12-00 NOTE 55p.; Paper presented at the Annual Meeting of the Speech Communication Association of Puerto Rico (18th, San Juan, Puerto Rico, December 4-5, 1998). PUB TYPE Reports Research (143) Speeches/Meeting Papers (150) EDRS PRICE MF01/PC03 Plus Postage. DESCRIPTORS *College Curriculum; *Communication (Thought Transfer); Comparative Analysis; *Educational Change; Educational Research; Foreign Countries; Global Approach; Higher Education; *International Education IDENTIFIERS *Internationalism ABSTRACT This paper surveys the current situation of internationalism among the various nation states by a comparative analysis, as matrix, to promulgate the internationalizing process, as a worthwhile goal, within and without the college and university curricula; the theoretical influence and contributions of scholars in communication, international education, and political-economy, moreover, become allies toward this endeavor. The paper calls for the promulgation of a new and more effective educational paradigm; in this respect, helping the movement toward the creation of new and better schools for the next millennium. The paper profiles "poorer nations" and "richer nations" and then views the United States, with its enormous wealth, leading technology, vast educational infrastructure, and its respect for democratic principles, as an agent with agencies that can effect positive consequences to ameliorating the status quo. The paper presents two hypotheses: the malaise of the current educational paradigm is real, and the "abertura" (opening) toward a better paradigmatic, educational pathway is advisable and feasible. -
SVP's Letter to Editors of Journals and Publishers on Burmese Amber And
Society of Vertebrate Paleontology 7918 Jones Branch Drive, Suite 300 McLean, VA 22102 USA Phone: (301) 634-7024 Email: [email protected] Web: www.vertpaleo.org FEIN: 06-0906643 April 21, 2020 Subject: Fossils from conflict zones and reproducibility of fossil-based scientific data Dear Editors, We are writing you today to promote the awareness of a couple of troubling matters in our scientific discipline, paleontology, because we value your professional academic publication as an important ‘gatekeeper’ to set high ethical standards in our scientific field. We represent the Society of Vertebrate Paleontology (SVP: http://vertpaleo.org/), a non-profit international scientific organization with over 2,000 researchers, educators, students, and enthusiasts, to advance the science of vertebrate palaeontology and to support and encourage the discovery, preservation, and protection of vertebrate fossils, fossil sites, and their geological and paleontological contexts. The first troubling matter concerns situations surrounding fossils in and from conflict zones. One particularly alarming example is with the so-called ‘Burmese amber’ that contains exquisitely well-preserved fossils trapped in 100-million-year-old (Cretaceous) tree sap from Myanmar. They include insects and plants, as well as various vertebrates such as lizards, snakes, birds, and dinosaurs, which have provided a wealth of biological information about the ‘dinosaur-era’ terrestrial ecosystem. Yet, the scientific value of these specimens comes at a cost (https://www.nytimes.com/2020/03/11/science/amber-myanmar-paleontologists.html). Where Burmese amber is mined in hazardous conditions, smuggled out of the country, and sold as gemstones, the most disheartening issue is that the recent surge of exciting scientific discoveries, particularly involving vertebrate fossils, has in part fueled the commercial trading of amber. -
A Concise Dictionary of Paleontology Second Edition
springer.com Life Sciences : Evolutionary Biology Carlton, Robert L. A Concise Dictionary of Paleontology Second Edition Presents a unique English language dictionary of paleontological terms, taxa, localities, and concepts Focuses on the most common orders, genera, and species, paying careful attention to overall historical significance in terms of turning points such as mass extinctions Written for students, libraries, museums, and general readers of scientific literature This new and significantly updated authored dictionary is a unique glossary of paleontological Springer terms, taxa, localities, and concepts. It focuses primarily on identifying the most significant 2nd ed. 2019, XII, 469 p. groups of fossil animals and plants in relation to their evolution and phylogeny. It also focuses 2nd on mass extinctions, on taxa that are problematic in some significant way, on the principal edition fossil-Lagerstätten of the world, and on historical turning points marked by index fossils. Although there are many current resources on the subject, none contains an accurate representation of the paleontological lexicon. Although well aware that the fast-changing field Printed book of paleontology will always defy any attempt at complete description, the author has attempted Hardcover to provide an accurate and comprehensive set of about 4,000 entries that will be useful to professionals as well as to general readers of scientific literature without a background in Printed book paleontology. Hardcover ISBN 978-3-030-25585-5 £ 149,99 | CHF 200,50 | 169,99 € | Order online at springer.com/booksellers Springer Nature Customer Service Center GmbH 186,99 € (A) | 181,89 € (D) Customer Service Available Tiergartenstrasse 15-17 Discount group 69121 Heidelberg Standard (0) Germany T: +49 (0)6221 345-4301 Product category [email protected] Dictionary Other renditions Softcover ISBN 978-3-030-25588-6 Softcover ISBN 978-3-030-25587-9 Prices and other details are subject to change without notice. -
The Greatest Challenge to 21St Century Paleontology: When Commercialization of Fossils Threatens the Science
Palaeontologia Electronica http://palaeo-electronica.org The greatest challenge to 21st century paleontology: When commercialization of fossils threatens the science Kenshu Shimada, Philip J. Currie, Eric Scott, and Stuart S. Sumida As we proceed into the 21st century, the sci- responses to geological and climatic factors. Pale- ence of paleontology has achieved a remarkable ontology presently enjoys a new “Golden Age,” prominence and popularity, providing increasingly progressing by leaps while also serving, as always, detailed perspective on critical biological and geo- to inspire young minds to explore science and the logical processes. Spectacular new discoveries natural world. excite the imagination and spur new investigations, Yet at the outset of the millennium, three inter- while more abundant fossils studied using new connected, troubling challenges confront paleontol- techniques enable more precise interpretations of ogists: 1) a shrinking job market, 2) diminishing diversity, variation, changes through time, and funding sources, and 3) heightened commercial- Editor’s note: The commercial collection and sale of fossils, as well as the still developing regulations involving collection of fossils on public lands, have emerged as one of the most contentious issues in pale- ontology. These issues pit not only professional paleontologists and commercial collectors against each other, but have produced rifts within the paleontological community. Here Shimada and his co-authors vig- orously present a position supported by many vertebrate paleontologists. I repeat a call in an earlier com- mentary (Plotnick, 2011; palaeo-electronica.org/2011_1/commentary/mainstream.htm) for additional contributions that would discuss these issues that are so crucial to our field. Please send directly to Roy E. -
Application Scientist (M/F/D) Biophysical Methods
CAREERS JOIN OUR TEAM Application Scientist (m/f/d) Biophysical Methods Munich, Germany We are a growing provider of scientific instruments for the analysis of molecular interactions and are seeking highly motivated individuals to join our team as Application Scientists for our innovative heliX® biosensors. We welcome applications from high-potentials who want to use their innovative minds to realize novel biophysical assays and to push the limits of what is possible in biosensing. If you like: • applied science and collaborating with scientists, technical sales, software developers and engineers • advanced scientific instruments for high-end research challenges in academia and industry • conformational changes, molecular interactions and investigating binding kinetics, affinities, enzymatic activity, and thermodynamics of biomolecules • advancing a pioneering biosensing technology (switchSENSE®), developing new biophysical assays to fight cancer and other diseases, and being embedded at the forefront of next-generation drug development • being a technical expert who enjoys providing advice, training, and hands-on support • traveling and an international work environment And if you have: • a friendly personality with great team spirit • training in biophysics, physics, biochemistry, chemistry, molecular biology, biotechnology, or similar (MSc, or PhD level) • a positive, hands-on attitude combined with a relentless will to get things to work • excellent communication and presentation skills • the ability to manage several projects simultaneously