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A Review on Nanoparticles, Their Preparation and Applications Ashish A Review Article ISSN: 0976-7126 CODEN (USA): IJPLCP Gawai et al., 11(4):6540-6548, 2020 [[ A Review on nanoparticles, their preparation and applications Ashish A. Gawai, Rahul J. Sarode and K.R. Biyani Anuradha College of Pharmacy, Chikhli, Buldana, (M.S) - India Abstract Article info The aim of pharmaceutical nanotechnology is to deliver the drug in the form of nanoparticles by enhancing their therapeutic potential. Received: 30/01/2020 Nanoparticles are solid colloidal particles ranging size 10 to 1000 nanometer, nanoparticle possess a matrix structure which incorporate Revised: 28/02/2020 pharmacological active substances & facilitate control release of active agent. While the nano capsule contains an oily core incorporating drug Accepted: 13/04/2020 surrounded by membrane structure. Nanoparticals use to successfully deliver the verity of drug protein, peptide & genes to cell both as non- © IJPLS targeted & targeted form. Drug can coupled in monomers that are specific for cell & organs. This strategies use to concentrate drug in www.ijplsjournal.com selected targeted tissues thus minimizing side effect & toxicity. Nanoparticles are prepared from either synthetic or natural macro molecules using two distinct techniques that is bottom up& top down technology. The bottom up technology adopts method to aggregate molecule into particle of nano range, while top-down adapt to breaking down macro molecules into nano range. Nano-tubes are used to deliver drug into targeted tissue cell & organs meanly use Carbon nanotube membrane. DNA nanotube, pharmaceutical nanoparticle are those where the drug is dissolved entrapped encapsulated or adsorbed on surface. Keywords: Nanoparticles, Encapsulated, Nanopolymers Introduction Nanoparticle is a small object that behaves as a therapeutic efficacy &reduction in side effect can whole unit in terms of its transport & properties, be achieved by various routs of administration size of nanoparticle is 1 to 100 nanometer, including oral, nasal, injection and intraocular use. nanocluster have at least one dimension between 1 Copper nanoparticles smaller than 50 nanometer & 10 nanometer & narrow size distribution, are consider super hard material that do not nanopowder on the other hand are agglomerates exhibit the same malleability & ductility as bulk of ultrafine particles of nanoparticle or copper. Ferroelectric nano particle are smaller nanocluster. Nanoparticle size crystals are called than10 nanometer. Suspension of nanoparticle are nanocrystals.1-4The size and surface characteristics possible because the interaction of particle surface of nano particles can be easily manipulated and with the solvent is strong enough to overcome this could be use for both passive & active differences in density which usually result in targeting. Nanoparticles can be made to control & material either sinking or plotting liquid. sustained release of the drug during the transportation as well as the location of the *Corresponding Author release. Since distribution & clearance of the drug E.mail: [email protected] from the body can be altered & increase in drug International Journal of Pharmacy & Life Sciences Volume 11 Issue 4: April. 2020 6540 Review Article ISSN: 0976-7126 CODEN (USA): IJPLCP Gawai et al., 11(4):6540-6548, 2020 Gold nanoparticle appears deep red to black in fluid. Platinum nanoparticles can be made with solution size 1 to 10 nanoparticle. They have very size between 2 to 20 nm. Platinum nanoparticle high surface area to volume ratio. The coarse suspended in the brownish red or black color in particle are in the range 10000 to 2500 nanometer, colloidal solution.12 then fine partical are in the range 2500 to 100 4) Gold Nanoparticles nanometer &nano particle are in the range 100 to Gold nanoparticles are used in immunochemical 1 nanometer.5-7 studies for identification of protein interaction. They are used as a Lab tracer to detect presence of Classes of Nanoparticle DNA in a sample. Gold is even use in some The nanoparticles can be of Polysaccharide, medicines for targeted drug delivery system. The powders & granules, protein & antibodies, soil & gold nanoparticleis more beneficial as it really sediments, surface &interfaces, suspension small with diameter of 5 nm or less.13 slurries & pastes, viruses & vaccines.8 5) Silver Nanoparticle Silver nanoparticles are used to kill bacteria Use of nanoparticle in biology & medicine9 because of good electrical & thermal conductivity. 1) Creating Fluorescent biological labels for It contains large number of silver ions & its important biological markers & molecule in surface use in antimicrobial agent.14-15 research & diagnosis of disease. 2) Gene delivery system in gene therapy General Method of synthesis of nanoparticle 3) For biological detection of disease causing The process of condensation leads to fine powder organisms & diagnosis with irregular particle sizes and shapes intypical 4) Detection of proteins powder. These may lead to non-uniformity of 5) Isolation & purification of biological structure in the package nanoparticle that may molecules & cell in research lead in packaging density variation in the compact 6) Probing of DNA structure powder. In addition un controlled agglomeration 7) Genetic and tissue engineering of powder due to attractive Vander walls forces 8) Destruction of tumors with drugs may also results in non-homogenous formation 9) In MRI studies nano-clusters & nano particles packages. There 10)In pharmacokinetic study are variations in stresses that can result in non- Types of Nanoparticles use in Pharmacy uniform drying shrinkage & this is directly 1) Magnetic Nanoparticles proportional to the rate at which the solvent can These are the class of Nanoparticles which can be be removing. Porosity & its distribution these manipulated using magnetic field which determines the process to a large extent, such commonly consist of magnetic elements such as stresses have been associated with a plastic to iron, nickel, cobalt etc. While magnetic brittle transitionin consolidated bodies & lead to nanoparticles smaller than 1 micrometer in propagation of cracks. Homogeneity may further diameter i.e., (5-500nm) have been focus of much be compromised where there are fluctuations in research because they possess attractive packing density in the compact as it is prepared properties.10 for during the sintering process. Some pores & 2) Iron Oxide nanoparticle other structural defects associated with density With diameter between 1 to 100 nm, the two main variations have been shown to play a detrimental forms of iron oxide nanoparticles i.e., magnetic role in the sintering process. Finally produce nano and magnetite have attracted extensive interest material of uniform size & shape most important due to their super paramagnetic properties and the distribution of components and porosity.16 potential application in Pharmaceuticals use in catalysis, sensor, medical diagnosis and Uniformity of Nanoparticles therapeutics.11 In the synthesis of nanoparticle, high purity and 3) Platinum Nanoparticle uniformity of structure is necessary for putting Usually in the form of suspension or collides of this particle to use. There must be high purity sub micrometer size particle of platinum in a ceramic polymers, glass ceramic & material International Journal of Pharmacy & Life Sciences Volume 11 Issue 4: April. 2020 6541 Review Article ISSN: 0976-7126 CODEN (USA): IJPLCP Gawai et al., 11(4):6540-6548, 2020 composites in creation of this particle. into the aqueous phase containing pluronic Nanoparticle is generally classified based on their f68under magnetic stirring. The colloidal dimensionality, morphology, composition, suspension obtained was concentrated by agglomeration and uniformity.17 evaporation under vacuum & filter to obtain nanocapsule. The nano capsule possess cell like Nanoparticle can improve medical diagnostic structure with a wall thickness of 3nm around Early detection of disease remains a primary goal nanocapsule& pH range is 4 to 10.Similar to of the medical community. Nanoparticle holds prepared (PIHCA) polyisohexylacynoacrylate great promise to achievement of this goal. involving treatment of monomer with sulphur Nanoparticle in particular have exhibited dioxide & dissolved in a solution containing tremendous potential for detecting fragment of miglyol810 in ethanol, this solution was added viruses, pre-cancerous cells, disease markers & slowly in 1:2 ratio into aqueous phase containing indicators of radiation damage. Gold coating has solution of 0.5% poloxamer 407 & 10mm made it possible to use toxic cobalt nanoparticles phosphate buffer under stirring were purified for biomedical application. Gold coated centrifugation & washing with distilled water. ferromagnetic nanoparticle tagged with HIV The presence of non-ionic surfactant allowed antibodies may be able to detect virus particles polymerization of ethyl cyanoacrylate at O/W left after completion of conventional drug interface. Thus encapsulating miglyol812 droplets therapy.18 the immediate polymerization triggered formation of drug loaded nanocapsule. The suspension were Nanoparticle can improve targeted drug concentrated under vacuum to remove acetone to delivery method produce smaller size nanocapsule.21,22 Targeted drug delivery system can convey drugs more effectively and more conveniently that Nanotubes23 increases patient’s compliance, extent the product Nanotubes are generally used to deliver drug into life cycle, provide product differentiation & targeted cell,
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