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A Case of Acute Myocardial Injury – MINOCA Or Myocarditis?

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A Case of Acute Myocardial Injury – MINOCA Or Myocarditis? CASE REPORT CARDIOLOGY // INFECTIOUS DISEASES A Case of Acute Myocardial Injury – MINOCA or Myocarditis? Camelia Libenciuc1, Răzvan-Andrei Licu1, Istvan Kovacs1,2, Monica Chitu1,2, Imre Benedek1,2 1 Clinic of Cardiology, Emergency Clinical County Hospital, Târgu Mureș, Romania 2 Center of Advanced Research in Multimodality Cardiac Imaging, CardioMed Medical Center, Târgu Mureș, Romania CORRESPONDENCE ABSTRACT Răzvan-Andrei Licu Myocardial infarction with non-obstructive coronary arteries (MINOCA) has been defined as clini- Str. Gheorghe Marinescu nr. 50 cal presentation of an acute coronary syndrome with laboratory evidence of myocardial necro- 540136 Târgu Mureș, Romania sis, but with coronary stenosis of less than 50% on coronary angiography. On the other side, Tel: +40 265 212 111 myocarditis is an inflammatory response triggered by viral, bacterial, fungal, lymphocytic, eo- E-mail: [email protected] sinophilic, or autoimmune myocardial injury, which may be associated with elevated myocardial necrosis serum biomarkers. We present the case of a young male patient with acute chest pain, ARTICLE HISTORY ST-segment elevation, and high-sensitivity troponin levels of 22,162 ng/L. Received: July 9, 2020 Keywords: myocarditis, MINOCA, acute myocardial injury, troponin levels Accepted: August 25, 2020 INTRODUCTION Myocardial infarction with non-obstructive coronary arteries (MINOCA) oc- curs in 6% of patients with myocardial infarction and has been defined as the clinical picture of an acute myocardial infarction with less than 50% stenosis in the main epicardial coronary arteries.1 The proposed mechanisms involved in MINOCA include coronary spasm, myocarditis, microvascular dysfunction, Takotsubo syndrome, or coronary embolism. Twelve-month mortality rates in patients with MINOCA have been reported up to 4.7%.2 Myocarditis, one of the main differential diagnoses of MINOCA, is an inflammatory response triggered by various viral, bacterial, or fungal infections, but may also be caused by auto- immune disorders. Myocarditis was found in 12% of young adults, and could lead to dilated cardiomyopathy and subsequent heart failure.3 The diagnosis of myocarditis is established on the basis of histological, immunological, immuno- histochemical, and molecular criteria; however, the diagnosis and cause of myo- Camelia Libenciuc • Str. Gheorghe Marinescu nr. 50, 540136 Târgu Mureș, Romania. Tel: +40 265 212 111, carditis are certified by endomyocardial biopsy. Cardiac magnetic resonance E-mail: [email protected] imaging (CMR) allows morpho-functional characterization of the myocardium, Istvan Kovacs • B-dul 22 Decembrie 1989 nr. 76, 540124 Târgu Mureș, Romania. Tel: +40 265 217 333, and it can provide important prognostic information. Furthermore, CMR al- E-mail: [email protected] lows the quantification of myocardial fibrosis and extension of the scar tissue Monica Chitu • B-dul 22 Decembrie 1989 nr. 76, 540124 Târgu Mureș, Romania. Tel: +40 265 217 333, following various disorders that trigger myocardial injury.4 E-mail: [email protected] Imre Benedek • B-dul 22 Decembrie 1989 nr. 76, 540124 Târgu Mureș, Romania. Tel: +40 265 217 333, E-mail: [email protected] Journal of Interdisciplinary Medicine 2020;5(3):120-125 DOI: 10.2478/jim-2020-0024 Journal of Interdisciplinary Medicine 2020;5(3):120-125 121 CASE REPORT examination. Therefore, an emergency invasive coronary angiography was performed, which revealed angiographi- A 44-year-old male patient with no cardiovascular history cally normal coronary arteries (Figure 2). presented to the emergency department complaining of During hospitalization, the patient presented dynamic acute onset of a constrictive chest pain, irradiating in the ECG changes consistent with the evolution of an acute myo- left upper limb, lasting more than 20 minutes and accom- cardial infarction, with the occurrence of negative T waves panied by diaphoresis and dyspnea, which had started 12 in the chest leads which had presented ST-segment eleva- hours prior to presentation. Clinical examination revealed tion (Figure 3). Laboratory tests revealed increased inflam- a blood pressure of 130/85 mmHg and heart rate of 79 matory serum biomarkers with an erythrocyte sedimenta- beats per minute, and no other signs of organ failure. tion rate of 69 mm/h, and a positive C-reactive protein. The 12-lead ECG performed in the emergency room Due to the absence of obstructive coronary artery dis- showed sinus rhythm, intermediate QRS axis, and ST-seg- ease upon invasive coronary angiography, a CMR imag- ment elevation of 0.5–1 mm in leads DI, DII, aVL, aVF, and ing was performed on day 5 of hospitalization, to exclude V4–V6 (Figure 1). myocarditis and other non-ischemic myocardial disorders. Blood sampling for detection of myocardial necrosis CMR examination showed the presence of a non-ischemic were obtained and the results revealed an increased high- lesion located in the subepicardial region of the lateral free sensitivity troponin I level of 26,162 ng/L, CK-MB of 155.5 wall of the left ventricle (Figure 4). ng/mL, and a total creatine kinase of 1,531 U/L. The FO- The presence of a non-ischemic lesion on CMR exami- CUS echocardiography conducted in the emergency room nation, accompanied by elevated inflammatory biomarker revealed a mildly impaired left ventricular systolic func- levels, leads to a high suspicion of myocarditis. In the ab- tion, with a left ventricular ejection fraction of 50%, with sence of an endomyocardial biopsy for a definitive diagno- discrete lateral wall hypokinesis, no significant valvular sis, viral serology was performed for detection of various disease, and no modifications in the pericardium. Several viral infections with possible tropism for the myocardial criteria of acute posterolateral ST-segment elevation myo- tissue, including anti-Cytomegalovirus IgM negative an- cardial infarction (STEMI) were identified: chest pain, tibodies (negative), anti-Cytomegalovirus IgG positive ST-segment elevation in more than two concordant chest antibodies (positive), anti-Toxoplasma antibodies type leads, serological evidence of myocardial necrosis, and re- IgM (negative) and IgG (positive), anti-rubella antibod- gional wall motion abnormalities on echocardiographic ies IgM (negative), Ig G (positive), and HIV antibody test FIGURE 1. ECG performed during chest pain episode showing an ST-segment elevation in DI, DII, aVL, aVF, and V4–V6 leads 122 Journal of Interdisciplinary Medicine 2020;5(3):120-125 A B FIGURE 2. Coronary angiography revealing normal epicardial coronary arteries. A – left coronary artery; B – right coronary artery (negative). The viral serology results were not specific, and antagonist as a triple neurohormonal blockade, in order to a positive diagnosis of viral myocarditis could not be es- prevent left ventricular remodeling following an extensive tablished. However, due to the presence of a non-ischemic myocardial injury, albeit non-ischemic. The patient agreed lesion on the CMR examination, MINOCA was excluded. to the publication of his data, and the institution where the The patient was prescribed angiotensin-converting en- patient had been admitted, approved the publication of zyme inhibitors, beta blockers, and a mineralocorticoid the case. FIGURE 3. ECG on day 3 showed negative T waves in DI, DII, aVL, aVF, and V4 Journal of Interdisciplinary Medicine 2020;5(3):120-125 123 A B FIGURE 4. Cardiovascular magnetic resonance criteria for myocarditis: regional myocardial edema, hyperemia in images acquired early after contrast injection (A), and inflammatory necrosis in images acquired late (>10 minutes) after contrast injection (B) DISCUSSIONS Nevertheless, several differential diagnoses should be ex- MINOCA constitutes 6% to 14% of cases presenting with cluded. One of the most important differential diagnoses acute myocardial infarction.5 In the reported case, the pa- for MINOCA is myocarditis, which is suspected in case of tient presented acute chest pain, elevated cardiac necro- clinical context (chest pain, dyspnea, signs of heart fail- sis markers, and ST-segment elevation, and was initially ure), ischemic ECG changes, increased levels of myocar- diagnosed with acute myocardial infarction. However, dial necrosis enzymes in the presence of non-obstructive emergency coronary angiography demonstrated normal coronary arteries, and generally, in patients with a posi- coronary anatomy with no obstructive coronary lesions. tive history of recent viral infections or autoimmune disor- This raised an important differential diagnosis problem: ders.8 Until recently, endomyocardial biopsy was the most MINOCA or myocarditis? accurate method of diagnosis, but it is rarely used due to Studies have shown that myocarditis may mimic an its low availability and high rates of complications. CMR acute coronary syndrome at onset, which occurs especial- imaging remains the most accurate method of diagnosis ly in young males (17–39 years).6 Myocarditis shares some in acute myocarditis of various causes.9 In MINOCA pa- clinical and paraclinical characteristics with other diseases, tients, the clinical, laboratory, and angiographic findings including MINOCA. However, MINOCA does not pres- may be identical, but the CMR examination presents typi- ent severely elevated inflammatory biomarkers or positive cal modifications specific for each etiology.10 The CMR serology for viral infections.7 Even if in the reported case, aspect of myocarditis includes the presence of regional the patient had
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