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Acute Coronary Syndrome in Young Sub-Saharan Africans: A
Sarr et al. BMC Cardiovascular Disorders 2013, 13:118 http://www.biomedcentral.com/1471-2261/13/118 RESEARCH ARTICLE Open Access Acute coronary syndrome in young Sub-Saharan Africans: A prospective study of 21 cases Moustapha Sarr1, Djibril Mari Ba1, Mouhamadou Bamba Ndiaye1*, Malick Bodian1, Modou Jobe1, Adama Kane1, Maboury Diao1, Alassane Mbaye2, Mouhamadoul Mounir Dia1, Soulemane Pessinaba1, Abdoul Kane2 and Serigne Abdou Ba1 Abstract Background: Coronary heart disease remains the leading cause of death in developed countries. In Africa, the disease continues to rise with varying rates of progression in different countries. At present, there is little available work on its juvenile forms. The objective of this work was to study the epidemiological, clinical and evolutionary aspects of acute coronary syndrome in young Sub-Saharan Africans. Methods: This was a prospective multicenter study done at the different departments of cardiology in Dakar. We included all patients of age 40 years and below, and who were admitted for acute coronary syndrome between January 1st, 2005 and July 31st, 2007. We collected and analyzed the epidemiological, clinical, paraclinical and evolutionary data of the patients. Results: Hospital prevalence of acute coronary syndrome in young people was 0.45% (21/4627) which represented 6.8% of all cases of acute coronary syndrome admitted during the same period. There was a strong male predominance with a sex-ratio (M:F) of 6. The mean age of patients was 34 ± 1.9 years (range of 24 and 40 years). The main risk factor was smoking, found in 52.4% of cases and the most common presenting symptom was chest pain found in 95.2% of patients. -
The Management of Acute Coronary Syndromes in Patients Presenting
CONCISE GUIDANCE Clinical Medicine 2021 Vol 21, No 2: e206–11 The management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: key points from the ESC 2020 Clinical Practice Guidelines for the general and emergency physician Authors: Ramesh NadarajahA and Chris GaleB There have been significant advances in the diagnosis and international decline in mortality rates.2,3 In September 2020, management of non-ST-segment elevation myocardial the European Society of Cardiology (ESC) published updated infarction over recent years, which has been reflected in an Clinical Practice Guidelines for the management of ACS in patients international decline in mortality rates. This article provides an presenting without persistent ST-segment elevation,4 5 years after overview of the 2020 European Society of Cardiology Clinical the last iteration. ABSTRACT Practice Guidelines for the topic, concentrating on areas relevant The guidelines stipulate a number of updated recommendations to the general or emergency physician. The recommendations (supplementary material S1). The strength of a recommendation and underlying evidence basis are analysed in three key and level of evidence used to justify it are weighted and graded areas: diagnosis (the recommendation to use high sensitivity according to predefined scales (Table 1). This focused review troponin and how to apply it), pathways (the recommendation provides learning points derived from the guidelines in areas to facilitate early invasive coronary angiography to improve relevant to general and emergency physicians, including diagnosis outcomes and shorten hospital stays) and treatment (a (recommendation to use high sensitivity troponin), pathways paradigm shift in the use of early intensive platelet inhibition). -
SIGN 148 • Acute Coronary Syndrome
SIGN 148 • Acute coronary syndrome A national clinical guideline April 2016 Evidence KEY TO EVIDENCE STATEMENTS AND RECOMMENDATIONS LEVELS OF EVIDENCE 1++ High-quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias 1+ Well-conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias 1 - Meta-analyses, systematic reviews, or RCTs with a high risk of bias High-quality systematic reviews of case-control or cohort studies ++ 2 High-quality case-control or cohort studies with a very low risk of confounding or bias and a high probability that the relationship is causal Well-conducted case-control or cohort studies with a low risk of confounding or bias and a moderate probability that the 2+ relationship is causal 2 - Case-control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal 3 Non-analytic studies, eg case reports, case series 4 Expert opinion RECOMMENDATIONS Some recommendations can be made with more certainty than others. The wording used in the recommendations in this guideline denotes the certainty with which the recommendation is made (the ‘strength’ of the recommendation). The ‘strength’ of a recommendation takes into account the quality (level) of the evidence. Although higher-quality evidence is more likely to be associated with strong recommendations than lower-quality evidence, a particular level of quality does not automatically lead to a particular strength of recommendation. Other factors that are taken into account when forming recommendations include: relevance to the NHS in Scotland; applicability of published evidence to the target population; consistency of the body of evidence, and the balance of benefits and harms of the options. -
Risk Stratification in Acute Coronary Syndrome: Focus on Unstable Angina/Non-ST Segment Elevation Myocardial Infarction R Bugiardini
729 EDITORIAL Heart: first published as 10.1136/hrt.2004.034546 on 14 June 2004. Downloaded from Risk stratification in acute coronary syndrome: focus on unstable angina/non-ST segment elevation myocardial infarction R Bugiardini ............................................................................................................................... Heart 2004;90:729–731. doi: 10.1136/hrt.2004.034546 Although there have been advances in the management of fashion. Experts in a variety of fields make decisions using a more intuitive process of unstable angina/non-ST segment elevation myocardial recognising patterns and applying their own infarction syndromes, the rate of cardiovascular mortality rules. In varying proportions, pathophysiologic after discharge is still unacceptably high. With many reasoning, personal clinical experience, and recent published research each play a role in therapeutic options available, the clinician is challenged to the development of our own clinical rules. This identify the safest and most effective treatment for long term approach may produce incorrect use of tools of survival of each individual patient risk stratifications and inappropriate use of treatment strategies and procedures. However, ........................................................................... errors are more often due to ‘‘failure’’ of the system, not of the doctors. Most errors occur at the transfer of care, and particularly at the transfer from the outpatient to the inpatient ‘‘Simple, but not too simple’’—Albert Einstein sites. There are a number of programs now focusing on errors and strategies to reduce errors welve million individuals in the USA and (GAP, CRUSADE QI, JACHO).5–7 All of these 143 million worldwide have coronary artery programs focus on education of physicians, Tdisease. Two million US patients are better interaction between health care organisa- admitted annually to cardiac care units with tions and physicians, and appropriate use of care acute coronary syndromes (ACS). -
Treatment of Acute Coronary Syndrome
Acute Coronary Syndrome: Current Treatment TIMOTHY L. SWITAJ, MD, U.S. Army Medical Department Center and School, Fort Sam Houston, Texas SCOTT R. CHRISTENSEN, MD, Martin Army Community Hospital Family Medicine Residency Program, Fort Benning, Georgia DEAN M. BREWER, DO, Guthrie Ambulatory Health Care Clinic, Fort Drum, New York Acute coronary syndrome continues to be a significant cause of morbidity and mortality in the United States. Family physicians need to identify and mitigate risk factors early, as well as recognize and respond to acute coronary syn- drome events quickly in any clinical setting. Diagnosis can be made based on patient history, symptoms, electrocardi- ography findings, and cardiac biomarkers, which delineate between ST elevation myocardial infarction and non–ST elevation acute coronary syndrome. Rapid reperfusion with primary percutaneous coronary intervention is the goal with either clinical presentation. Coupled with appropriate medical management, percutaneous coronary interven- tion can improve short- and long-term outcomes following myocardial infarction. If percutaneous coronary interven- tion cannot be performed rapidly, patients with ST elevation myocardial infarction can be treated with fibrinolytic therapy. Fibrinolysis is not recommended in patients with non–ST elevation acute coronary syndrome; therefore, these patients should be treated with medical management if they are at low risk of coronary events or if percutaneous coronary intervention cannot be performed. Post–myocardial infarction care should -
Coronary Artery Disease Management
HealthPartners Inspire® Special Needs Basic Care Clinical Care Planning and Resource Guide CORONARY ARTERY DISEASE MANAGEMENT The following Evidence Base Guideline was used in developing this clinical care guide: National Institute of Health (NIH); American Heart Association (AHA) Documented Health Condition: Coronary Artery Disease, Coronary Heart Disease, Heart Disease What is Coronary Artery Disease? Coronary artery disease (CAD) is a disease in which a waxy substance called plaque builds up inside the coronary arteries. These arteries supply oxygen‐rich blood to your heart muscle. When plaque builds up in the arteries, the condition is called atherosclerosis (ATH‐er‐o‐skler‐O‐sis). The buildup of plaque occurs over many years. Over time, plaque can harden or rupture (break open). Hardened plaque narrows the coronary arteries and reduces the flow of oxygen‐rich blood to the heart. If the plaque ruptures, a blood clot can form on its surface. A large blood clot can mostly or completely block blood flow through a coronary artery. Over time, ruptured plaque also hardens and narrows the coronary arteries. Common Causes of Coronary Artery Disease? If the flow of oxygen‐rich blood to your heart muscle is reduced or blocked, angina or a heart attack can occur. Angina is chest pain or discomfort. It may feel like pressure or squeezing in your chest. The pain also can occur in your shoulders, arms, neck, jaw, or back. Angina pain may even feel like indigestion. A heart attack occurs if the flow of oxygen‐rich blood to a section of heart muscle is cut off. If blood flow isn’t restored quickly, the section of heart muscle begins to die. -
Cardiology 1
Cardiology 1 SINGLE BEST ANSWER (SBA) a. Sick sinus syndrome b. First-degree AV block QUESTIONS c. Mobitz type 1 block d. Mobitz type 2 block 1. A 19-year-old university rower presents for the pre- e. Complete heart block Oxford–Cambridge boat race medical evaluation. He is healthy and has no significant medical history. 5. A 28-year-old man with no past medical history However, his brother died suddenly during football and not on medications presents to the emergency practice at age 15. Which one of the following is the department with palpitations for several hours and most likely cause of the brother’s death? was found to have supraventricular tachycardia. a. Aortic stenosis Carotid massage was attempted without success. b. Congenital long QT syndrome What is the treatment of choice to stop the attack? c. Congenital short QT syndrome a. Intravenous (IV) lignocaine d. Hypertrophic cardiomyopathy (HCM) b. IV digoxin e. Wolff–Parkinson–White syndrome c. IV amiodarone d. IV adenosine 2. A 65-year-old man presents to the heart failure e. IV quinidine outpatient clinic with increased shortness of breath and swollen ankles. On examination his pulse was 6. A 75-year-old cigarette smoker with known ischaemic 100 beats/min, blood pressure 100/60 mmHg heart disease and a history of cardiac failure presents and jugular venous pressure (JVP) 10 cm water. + to the emergency department with a 6-hour history of The patient currently takes furosemide 40 mg BD, increasing dyspnoea. His ECG shows a narrow complex spironolactone 12.5 mg, bisoprolol 2.5 mg OD and regular tachycardia with a rate of 160 beats/min. -
Acute Coronary Syndrome Summit October 25, 2016 Objectives
2014 NSTE-ACS Guidelines Overview Kelly Hewins, MSN, RN, CPHQ, CEN Acute Coronary Syndrome Summit October 25, 2016 Objectives At the end of this presentation the learner will be able to: • Locate resources on ACS, Troponin, Risk Assessment, and online Guideline Transformation Optimization consumables • Understand the ACS continuum of care • Verbalize how the semantic differences between UA/NSTEMI/STEMI fit into an ACS System of Care program • Review Mission: Lifeline NSTEMI measures’ supporting science and data specs Audience Poll Are you: • Full time abstractor • Chest Pain Program coordinator/manager • With abstractor duties • Without abstractor duties • Multiple titles such as manager, STEMI and Stroke Coordinator etc. • Staff nurse with program coordination duties • Staff nurse with data abstraction duties • All of the above Online Resource to Help Your Program’s Uptake of NSTEMI Guidelines The Guideline Transformation & Optimization Initiative Amsterdam, E. A. et al. (2014). 2014 AHA/ACC Guideline for the management of patients with non-ST-elevation acute coronary syndromes: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. Circulation, e344-426. Retrieved from http://circ.ahajournals.org/content/130/25/e344.full.pdf+html . doi: 10.1161/circ.0000000000000134. Understanding Terminology and Semantic Influence Human Brain thinks in pictures while subconsciously looking for patterns Consider the Semantics of every interaction SHARK Acute Coronary Syndrome (ACS) “ACS has evolved as a useful operational term that refers to a spectrum of conditions compatible with acute myocardial ischemia and/or infarction that are usually due to an abrupt reduction in coronary blood flow.” ACS also refers to patients with Symptoms which occur due to a partial or total blockage of a coronary artery causing myocardial • ischemia (cells starving of oxygen) OR • infarction (cell death). -
Prognosis in Unstable Angina'
Br Heart J: first published as 10.1136/hrt.38.9.921 on 1 September 1976. Downloaded from British Heart J7ournal, 1976, 38, 921-925. Prognosis in unstable angina' Ming-Kiat Heng, Robin M. Norris, Bramah N. Singh, and John B. Partridge From the Departments of Cardiology, Coronary Care, and Radiology, Green Lane Hospital, and the Department of Medicine, University of Auckland, New Zealand A retrospective study was made of 158 patients with unstable angina admitted to a coronary care unit over a 4-year period. Twenty patients (13 per cent) had myocardial infarcts while in hospital, and of these 3 died; three others died without preceding evidence of myocardial infarction. There was thus an acute mortality rate of 4 per cent. Patients with persisting angina after thefirst 24 hours and those without a previous history of myocardial ischaemia were more likely to develop a myocardial infarct or to die in hospital. Follow-up information, ranging from 3 to 7 years, was available in 144 of 152 hospital survivors. Patients older than 60years (P< 0-05), with cardiomegaly (P< 0.01) and with pulmonary venous congestion (P< 0 05) were found to have significantly increased long-term mortality. Long-term mortality was also found to rise with increasing coronary prognostic index. The average mortality rate for the whole group of hospital survivors was about 5 per cent per annum. Of the 111 patients who were alive at follow-up, 19 (17%) had had a myocardial infarct after leaving hospital, and a similar number had moderate or severe angina. Many patients with acute myocardial infarction studied a group of such patients admitted to a describe a change in the character of angina before coronary care unit. -
Coronary Artery Disease Is Associated with Valvular Heart Disease, but Could It Be a Predictive Factor?
Indian Heart Journal 71 (2019) 284e287 Contents lists available at ScienceDirect Indian Heart Journal journal homepage: www.elsevier.com/locate/ihj Short Communication Coronary artery disease is associated with valvular heart disease, but could it Be a predictive factor? * Anthony Matta a, , Nicolas Moussallem a, b, c a Faculty of Medicine, Holy Spirit University of Kaslik, Kaslik, Lebanon b Past President of Lebanese Society of Cardiology c Fellow of European Society of Cardiology and American College of Cardiology article info abstract Article history: Objective: This study was conducted to evaluate the prevalence of significant coronary artery disease Received 13 February 2019 (CAD) in patients with severe valvular heart disease (VHD) and the association between these two Accepted 2 July 2019 cardiac entities. Our research aims to introduce the theory of a possible causal relationship. Available online 6 July 2019 Methods: A retrospective study was conducted on 1308 consecutive patients who underwent surgery for severe VHD in the cardiovascular department of Notre-Dame de Secours University Hospital (NDSUH) Keywords: between December 2000 and December 2016. According to transthoracic echocardiography, patients Coronary artery disease were divided into 4 groups: patients with severe aortic stenosis (AS), patients with severe aortic Prevalence Aortic valve disease regurgitation (AR), patients with severe mitral stenosis (MS), and patients with severe mitral regurgi- Aortic tation (MR). Preoperative coronary angiographies were reviewed for the presence or the absence of significant CAD (50% luminal stenosis). Chi-square test and 2 Â 2 tables were used. Results: Of the 1308 patients with severe VHD, 1002 patients had isolated aortic valve disease, 240 pa- tients had isolated mitral valve disease, and 66 patients had combined aortomitral valve disease. -
Cardiac Arrhythmias in Acute Coronary Syndromes: Position Paper from the Joint EHRA, ACCA, and EAPCI Task Force
FOCUS ARTICLE Euro Intervention 2014;10-online publish-ahead-of-print August 2014 Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA, and EAPCI task force Bulent Gorenek*† (Chairperson, Turkey), Carina Blomström Lundqvist† (Sweden), Josep Brugada Terradellas† (Spain), A. John Camm† (UK), Gerhard Hindricks† (Germany), Kurt Huber‡ (Austria), Paulus Kirchhof† (UK), Karl-Heinz Kuck† (Germany), Gulmira Kudaiberdieva† (Turkey), Tina Lin† (Germany), Antonio Raviele† (Italy), Massimo Santini† (Italy), Roland Richard Tilz† (Germany), Marco Valgimigli¶ (The Netherlands), Marc A. Vos† (The Netherlands), Christian Vrints‡ (Belgium), and Uwe Zeymer‡ (Germany) Document Reviewers: Gregory Y.H. Lip (Review Coordinator) (UK), Tatjania Potpara (Serbia), Laurent Fauchier (France), Christian Sticherling (Switzerland), Marco Roffi (Switzerland), Petr Widimsky (Czech Republic), Julinda Mehilli (Germany), Maddalena Lettino (Italy), Francois Schiele (France), Peter Sinnaeve (Belgium), Giueseppe Boriani (Italy), Deirdre Lane (UK), and Irene Savelieva (on behalf of EP-Europace, UK) Introduction treatment. Atrial fibrillation (AF) may also warrant urgent treat- It is known that myocardial ischaemia and infarction leads to severe ment when a fast ventricular rate is associated with hemodynamic metabolic and electrophysiological changes that induce silent or deterioration. The management of other arrhythmias is also based symptomatic life-threatening arrhythmias. Sudden cardiac death is largely on symptoms rather than to avert -
Emergency Management of Cardiac Chest Pain: a Review
6 Emerg Med J 2001;18:6–10 REVIEW Emerg Med J: first published as 10.1136/emj.18.1.6 on 1 January 2001. Downloaded from Emergency management of cardiac chest pain: a review K R Herren, K Mackway-Jones Chest pain accounts for 2%–4% of all new fer to coronary care, and also to limit the attendances at emergency departments (ED) impact on the patient and healthcare resources. in the United Kingdom.12 Chest pain can be The diagnosis of chest pains less than 12 the presenting complaint in a myriad of disor- hours in duration is an important challenge. ders ranging from life threats such as acute This is for three reasons. Firstly, individual myocardial infarction (AMI) to mild self limit- biochemical markers cannot eVectively rule ing disorders such as muscle strain. Possible out myocardial infarction in the initial 12 hour cardac chest pain can be viewed as a con- period.13 14 Secondly, aspirin and the fibrino- tinuum, ranging from total global AMI to sim- lytic agents are at their most potent during this ple short lived angina. Within this spectrum lie period,815 and finally the majority of AMI the acute coronary syndromes with critical car- related deaths occur in the first 12 hours.4 diac ischaemia and minimal myocardial dam- Ideally a test would be available that age. identifies all AMIs immediately and confi- Nationally over 129 000 deaths a year are dently excludes all non-AMIs. No perfect test attributable to ischaemic heart disease.3 AMI exists; instead tests are combined initially to case mortality is currently 45% with over 70% rule in myocardial infarction (RIMI), and then of these dying before they reach medical care.4 to eVectively rule out myocardial infarction One in eight patients with unstable angina will (ROMI).