Rapid Plasma Reagin (RPR), Response to Therapy, Serum

TEST OBSOLETE

Notification Date: March 13, 2019 Effective Date: April 16, 2019 Rapid Plasma Reagin (RPR), Response to Therapy, Serum

Test ID: RPRT

Explanation: Due to an assay change, test code RPRT will become obsolete and will be replaced by test code RPRRT on the effective date.

Recommended Alternative Test: Rapid Plasma Reagin Screen Response to Therapy, Serum

Test ID: RPRRT

Useful for: Determining the current disease status and evaluating response to therapy for syphilis.

Reflex Tests: Test ID Reporting Name Available Separately Always Performed

RRPRQ RPR Titer, S No No

Testing Algorithm: If this test is positive, rapid plasma reagin (RPR) titer (RRPRQ) will be performed at an additional charge.

Methods: RPRRT: Multiplex Flow Immunoassay RRPRQ: Flocculation/Agglutination

Reference Values: Nonreactive

Specimen Requirements: Container/Tube: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum

Minimum Volume: 0.4 mL

Serum Refrigerated (preferred) 14 days

Frozen 14 days

Cautions: Biological false-positive reactions with cardiolipin-type antigens have been reported in disease such as infectious mononucleosis, leprosy, malaria, lupus erythematosus, vaccinia, and viral pneumonia. Pregnancy, autoimmune diseases, and narcotic addictions may give false-positives. Pinta, yaws, bejel, and other treponemal diseases may also produce false-positive results with this test.

CPT Code: 0065U 86593-Rapid Plasma Reagin Titer (if appropriate)

Day(s) Setup: Analytic Time: Monday through Saturday; 9 a.m Same day/1 day

Questions Contact Dunisha Messmer, Laboratory Technologist Resource Coordinator at 800-533-1710.