DOCSLIB.ORG

Good Health Starts in the Gut Your Daily Challenges

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Good Health Starts in the Gut Your Daily Challenges Good health starts in the gut Your Daily Challenges • Providing real benefits for consumer wellbeing • Ensuring stable and appealing tastes and textures • Enhancing the naturally healthy image of your brand Consumers are discovering that a healthy gut is much more than good digestion. The DuPont Digestive Health Platform delivers targeted solutions for the growing gut health market If there is one thing that health-conscious consumers are a gut-friendly diet looks like, one that can relieve digestive increasingly aware of, it’s that good health and wellbeing discomfort, improve immune health, and support overall often starts in the gut. The rise in food product launches weight management. An increasing amount of studies also with a digestive health claim also reflects the general point to the connection between gut health and cognitive consumer preference for naturally functional foods and health as a future growth area in the market. beverages to meet their nutritional needs. To take advantage of these opportunities, you need the For food manufacturers, the gut health market represents right product development partner. That’s where DuPont a vast opportunity to explore. Euromonitor insights predict Nutrition & Biosciences comes in. Our Digestive Health the global digestive health market will continue to maintain Platform offers the ingredient solutions, application knowhow a 5.7% CAGR in retail value up to 2023 and beyond. and regulatory support you need to capture market share. The biggest potential lies with products that are enriched The key to your success is that consumers can feel with probiotics and fiber and are free from ingredients that a difference. By drawing on our nutritional, scientific, can cause intolerance, such as gluten and lactose. This would regulatory and functional capabilities, that’s a promise your allow products to align with consumers’ perceptions of what brand can keep. Benefits and gains Your business gains Your product benefits Our proven solution • Leverage the healthy image of your • Clinically documented ingredients • Premium probiotics brand • Appealing tastes and textures • Starter cultures • Achieve premium positioning • Free-from lactose/gluten • Prebiotic fibers (polydextrose, • Benefit from extensive technical and opportunities human milk oligosaccharides) regulatory support • Stability throughout shelf life • Functional systems, emulsifiers, • Reduce your time to market enzymes & hydrocolloids Solutions overview for food and beverage applications Digestive health Health benefits obtained via the gut Food food and beverage application Gut health segments Immune health Weight management Bifido B. lactis HN019™, documented for gut comfort Dophilus Protect Adult, L. acidophilus NCFM®, Probiotic fermented Yogurt, B. lactis Bl-04™, documented for well-being & gut dairy Drinking yogurt documented for immune comfort health YO-MIX® PRO series Single probiotic strains “All in One” yogurt cultures with probiotic species Plant-based dairy Probiotic fermented Danisco® VEGE Cultures, including alternatives, plant-based food and Dophilus Fermented juices, beverages and Bifido VEGE Tea etc. Bifido Bars, Protect Adult, Other probiotic food B. lactis HN019™ Beverages, B. lactis Bl-04™ Shape and beverages Cereals Dophilus Protect Earlylife B. lactis B420™ L. acidophilus NCFM® L. Rhamnosus HN001™ CARE4U™ Human Milk Oligosaccharides Food, Litesse® polydextrose Litesse® polydextrose CARE4U™ Human Milk Fibers / prebiotics Beverages, DuPont™ Danisco® Nurica™ FORTEFIBER™ Oligosaccharides Formula FIBRIM® Soy Fiber Soluble Dietary Fiber FORTEFIBER™ Soluble Dietary Fiber DuPont™ Danisco® Bonlacta™ Lactose-free Dairy, Formula GODO YNL-2 Lactase WELLENCE™ GF 321, POWERFlex® GF 4201, PowerBake® GF 101, Functional Systems, Hydrocolloids, Baked Enzymes, Emulsifiers, Soy Proteins, Gluten-free goods Pea nuggets, Litesse® polydextrose, FORTEFIBER™ Soluble Dietary Fiber, XIVIA® Xylitol, Fermentates is a line of clinically mastered probiotic solutions from the leading industry experts at DuPont HOWARU® premium probiotics are offered as single strains or pre-formulated blends, all validated by gold-standard clinical trials. Each robust strain or strain-combination provides an array of benefits sure to meet your manufacturing needs and that of your unique customer. The Human Microbiome Venture The human microbiome comprises all the microbes that live in and on the body. In fact, there are more microbes living in the human as there are cells in the human body. These microbes produce thousands of different metabolites and are responsible for as much as 30% of the metabolites found in human blood. Academic research over the past 10 years or so has demonstrated the significant role the microbiome plays in human health and disease. To spearhead the development of new microbiome science-based solutions, DuPont Nutrition & Biosciences has established the Human Microbiome Venture (HMV). This team will complement and build upon the existing leadership of DuPont in the areas of probiotics and prebiotics, including human milk oligosaccharides (HMOs), to deliver novel intervention options that can modulate the microbiome and exert a beneficial or even a therapeutic effect. The HMV team is also engaging in strategic partnerships with other microbiome leaders in academia and in the healthcare industry to accelerate product development and future commercialization of these products. THE MICROBIOME BY NUMBERS: Tens Of Trillions Of Microbial Cells The Scientific Community A Complex Microbial Has Been Studying Ecosystem The Microbiome For >1000 Species over 20 Years 30% Of The Metabolites Millions Found In Your Blood Are Of Microbial Coming From The Genes Microbiome Producing Over 500,000 Different Metabolites Application support All our solutions for digestive health have been developed and tested in the DuPont application centers. This, together with our extensive global presence and knowledge of food products, processes and regulations, make us a strong partner for your product development needs. DuPont™, the DuPont Oval Logo, and all trademarks and service marks denoted with ™, SM or ® are owned by affiliates of DuPont de Nemours, Inc. unless otherwise noted. © 2019 DuPont. The information contained herein is based on data known to DuPont or its affiliates at the time of preparation of the information and believed by them to be reliable. This is business-to-business information intended for food, beverage and supplement producers, and is not intended for the final consumer of a finished food, beverage or supplement product. The information is provided “as is” and its use is at the recipient’s sole discretion and risk. It is the recipient’s sole responsibility to determine the suitability and legality of its proposed use of DuPont products for its specific purposes. Information and statements herein shall not be construed as licenses to practice, or recommendations to infringe, any patents or other intellectual property rights of DuPont or others. DUPONT HEREBY EXPRESSLY DISCLAIMS (I) ANY AND ALL LIABILITY IN CONNECTION WITH SUCH INFORMATION, INCLUDING, BUT NOT LIMITED TO, ANY LIABILITY RELATING TO THE ACCURACY, COMPLETENESS, OR USEFULNESS OF SUCH INFORMATION, AND (II) ANY AND ALL Nutrition & Biosciences REPRESENTATIONS OR WARRANTIES, EXPRESS OR IMPLIED, WITH RESPECT TO SUCH INFORMATION, OR ANY PART THEREOF, INCLUDING ALL REPRESENTATIONS AND WARRANTIES OF TITLE, NONINFRINGEMENT OF COPYRIGHT OR PATENT RIGHTS OF OTHERS, MERCHANTABILITY, FITNESS OR SUITABILITY FOR ANY PURPOSE, PB 114-1 www.food.dupont.com AND WARRANTIES ARISING BY LAW, STATUTE, USAGE OF TRADE OR COURSE OF DEALING..
Load more

Recommended publications
  • Influence of Dietary Fiber Addition on the Properties of Probiotic Yogurt
    International Journal of Chemical Engineering and Applications, Vol. 5, No. 5, October 2014 Influence of Dietary Fiber Addition on the Properties of Probiotic Yogurt T. Ozcan and O. Kurtuldu low energy density, and should promote satiation and satiety, Abstract—In this study, the effects of using dietary fiber and play a role in the control of energy balance. These foods barley and oat β-glucan as a prebiotic on the viability of have the capacity of binding bile acids and metabolites of Bifidobacterium bifidum in probiotic yoghurt and properties of cholesterol that play an important role in digestion and yogurt during storage were investigated. The survival of B. absorption of lipids in the small intestine, lowering blood bifidum was within biotherapeutic level (> 7 log cfu/g) as a result of the prebiotic effect of barley and oat based β-glucan. cholesterol, regulating blood glucose levels for diabetes The addition of β-glucan to yogurt significantly affected management, producing short chain fatty acids and physicochemical properties including pH, titratable acidity promoting the growth of beneficial gut microflora (i.e. as a (LA %), whey seperation, color (L*, a*, b*) and sensorial prebiotic) [18]–[23]. Due to beneficiary health effects the properties of yogurts. In conclusion, β-glucan can be used on recommended daily intake of fiber is about 38 g for men and the development of cereal-based functional dairy products with sufficient viability and acceptable sensory characteristics. 25 g for women [24]. Fiber can be used for improvement of some functional Index Terms—Yoghurt, probiotic, dietary fiber, β-glucan. properties such as texture, water holding capacity, oil holding capacity, emulsification and/or gel formation, bulking agent in reduced-sugar applications, and shelf-life of I.
    [Show full text]
  • Probiotic Sufficiency™ Brochure
    Everybody - Everyday - For Life!TM Everybody Everyday For Life! ® RESEARCH INDICATES THAT: 1. Probiotic bacteria are ESSENTIAL for wellness and prevention. ® The human body contains 90% microorganisms Energy and only 10% human cells. Dietary sufficiency of healthy microorganisms (probiotics) is necessary for Vitality the proper function of the digestive and immune Strength systems and for overall wellness and prevention. Balance Natural Health 2. The Western diet is DANGEROUSLY DEFICIENT in Probiotic bacteria. Purity Research shows that we now consume one millionth of the healthy probiotic bacteria that we did before pesticides, herbicides, and industrial farming. We also kill many of our probiotic bacteria with poor nutrition, prescription drugs, and stress. This PROBIOTIC deficiency of healthy probiotic bacteria is implicated TM as a casual factor in lack of health and vitality and an alarming number of preventable illnesses from SUFFICIENCY infancy to old age. The Innate Human Probiotic Formula 3. The only way to obtain sufficient amounts of Everybody - Everyday - For Life!™ ® healthy probiotic bacteria is through daily How to consume Innate Choice PROBIOTIC SUFFICIENCY™ SUPPLEMENTATION. Please visit www.innatechoice.com for The dietary sources of probiotic bacteria are virtually The World’s Premier Multi-Strain a complete list of references supporting the A Dietary Supplement to Promote unavailable in industrialized society. Our fruits Probiotic Supplement importance of daily probiotic supplementation for Healthy Intestinal Flora and vegetables are sprayed with pesticides, much Adults should consume 2 capsules per day with a meal wellness and prevention. of our food is pasteurized or irradiated, and we do containing raw fruit or vegetables. not consume sufficient amounts of fresh, raw, local foods.
    [Show full text]
  • Analysis of the Effects of Three Commercially Available Supplements on Performance, Exercise Induced Changes and Bio-Markers in Recreationally Trained Young Males
    Analysis of the effects of three commercially available supplements on performance, exercise induced changes and bio-markers in recreationally trained young males Robert Cooper A thesis is submitted in partial fulfilment of the requirements of the University of Greenwich for the Degree of Doctor of Philosophy This research programme was carried out in collaboration with GlaxoSmithKline Maxinutrition division December 2013 School of Science University of Greenwich, Medway Campus Chatham Maritime, Kent ME4 4TB, UK i DECLARATION “I certify that this work has not been accepted in substance for any degree, and is not concurrently being submitted for any degree other than that of Doctor of Philosophy being studied at the University of Greenwich. I also declare that this work is the result of my own investigations except where otherwise identified by references and that I have not plagiarised the work of others”. Signed Date Mr Robert Cooper (Candidate) …………………………………………………………………………………………………………………………… PhD Supervisors Signed Date Dr Fernando Naclerio (1st supervisor) Signed Date Dr Mark Goss-Sampson (2nd supervisor) ii ACKNOWLEDGEMENTS Thank you to my supervisory team, Dr Fernando Naclerio, Dr Mark Goss Sampson and Dr Judith Allgrove for their support and guidance throughout my PhD. Particular thanks to Dr Fernando Naclerio for his tireless efforts, guidance and support in developing the research and my own research and communication skills. Thank you to Dr Eneko Larumbe Zabala for the statistics support. I would like to take this opportunity to thank my wonderful mother and sister who continue to give me the support and drive to succeed. Also on a personal level thank you to my amazing fiancée, Jennie Swift.
    [Show full text]
  • Flow Cytometric Analysis Reveals Culture-Condition Dependent Variations in Phenotypic Heterogeneity of Limosilactobacillus Reuteri
    Flow Cytometric Analysis Reveals Culture-condition Dependent Variations in Phenotypic Heterogeneity of Limosilactobacillus Reuteri Nikhil Seshagiri Rao Lund University Ludwig Lundberg Swedish University of Agricultural Sciences Shuai Palmkron Lund University Sebastian Håkansson BioGaia Björn Bergenståhl Lund University Magnus Carlquist ( [email protected] ) Lund University Research Article Keywords: Physical stress, heterogeneity, morphology, freeze-thaw, freeze-drying, ow cytometry Posted Date: June 22nd, 2021 DOI: https://doi.org/10.21203/rs.3.rs-625422/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/23 Abstract Optimisation of cultivation conditions in the industrial production of probiotics is crucial to reach a high- quality product with retained probiotic functionality. Flow cytometry-based descriptors of bacterial morphology may be used as markers to estimate physiological tness during cultivation, and can be applied for online monitoring to avoid suboptimal growth. In the current study, the effects of temperature, pH and oxygen levels on cell growth and cell size distributions of Limosilactobacillus reuteri DSM 17938 were measured using multivariate ow cytometry. A pleomorphic behaviour was evident from the measurement of light scatter and pulse width distributions. A pattern of high growth yielding smaller cells and less heterogeneous populations could be observed. Analysis of pulse width distributions revealed signicant morphological heterogeneities within the bacterial cell population under non-optimal growth conditions, and pointed towards low temperature, high pH, and high oxygen levels all being triggers for changes in morphology towards cell chain formation. However, cell size did not correlate to survivability after freeze-thaw or freeze-drying stress, indicating that it is not a key determinant for physical stress tolerance.
    [Show full text]
  • Your Gut, Your Health
    By Jill Nussinow, MS, RDN, The Veggie Queen A 2001 report by the Food and Agricultural Organization of the United Nations and the World Health Organization in 2001. The report defined probiotics as “live microorganisms which, when consumed in adequate amounts, confer a health benefit on the host.” YOU are the host The are “good bacteria” I am convinced that probiotic use in most people can enhance their immunity, promote regularity, lessen gas and bloating, and yes, even enhance their sex life! (It might clear up your skin, too) JoAnn Hatner, MPH, RD, author of Gut Insight Probiotics are big business which is why you see so many TV commercials and advertisements for them – people have tummy troubles regularly. Japan has been a leader in this field for more than 50 years. 25% of people report GI disturbance What are probiotics? Do they work? Think of your gut as your immune system's command center — responsible for the regulation of your responses, particularly of inflammation. >70 % of immune function takes place in your gut It makes sense as this is where the body encounters the majority of pathogens. Inflammation serves a protective role responding to tissue injury or infection so that you can heal. We have 10 times the amount of microbial cells than total other cells, with 500+ types of microorganisms which mostly reside in our gut. Your bacteria rules your life. They perform digestive and defensive roles against chronic inflammation and decreasing reactions to allergens plus they help in synthesizing B Vitamins Inhibit the growth of disease causing bacteria A probiotic: is a microbial organism which is not harmful (pathogenic) remains viable (alive) during processing and shelf life of the food must survive digestion and remain viable in the gut is able to bring about a response in the gut is associated with health benefits.
    [Show full text]
  • Development of Probiotic Almond Beverage Using Lacticaseibacillus Rhamnosus GR-1 Fortified with Short-Chain and Long-Chain Inulin Fibre
    fermentation Article Development of Probiotic Almond Beverage Using Lacticaseibacillus rhamnosus GR-1 Fortified with Short-Chain and Long-Chain Inulin Fibre Lauren Muncey and Sharareh Hekmat * School of Food and Nutritional Sciences, Brescia University College, Western University, London, ON N6G 1H2, Canada; [email protected] * Correspondence: [email protected]; Tel.: +519-432-8353 (ext. 28227) Abstract: Plant-based beverages are growing in popularity due to the rise of vegetarianism and other health trends. A probiotic almond beverage that combines the properties of almonds, inulin, and Lacticaseibacillus rhamnosus GR-1 may meet the demand for a non-dairy health-promoting food. The purpose of this study was to investigate the viability of L. rhamnosus GR-1 and pH in five fermented almond beverage samples, supplemented with either 2% or 5% (w/v) short-chain or long-chain inulin over 9 h of fermentation and 30 days of refrigerated storage. All almond beverage samples achieved a mean viable count of at least 107 CFU/mL during 9h of fermentation and 30 days of refrigerated storage. The probiotic almond beverage supplemented with 2% (w/v) short-chain inulin had a significantly higher mean microbial count (p = 0.048) and lower pH (p < 0.001) throughout fermentation, while the control and the long-chain inulin treatments had the lowest viable counts and acidity, respectively. This study shows that the addition of short-chain and long-chain inulin had Citation: Muncey, L.; Hekmat, S. no adverse effects on the viability of L. rhamnosus GR-1. Therefore, the probiotic almond beverage Development of Probiotic Almond has the potential to be a valid alternative to dairy-based probiotic products.
    [Show full text]
  • Glutamine Supplementation of Total Parenteral Nutrition in Surgical
    Probiotics and necrotizing enterocolitis Paul Fleming1,2, Nigel J Hall3,4 & Simon Eaton4 1Homerton University Hospital, 2Barts and the London School of Medicine and Dentistry, 3Faculty of Medicine, University of Southampton, 4UCL Institute of Child Health and Great Ormond Street Hospital for Children, London Corresponding author: Simon Eaton, PhD Department of Paediatric Surgery, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH UK Telephone: +44 (0)20 7905 2158 Fax: +44 (0)20 7404 6181 Email: [email protected] Keywords: necrotizing enterocolitis, probiotics, prevention, intestinal microbiota, premature infants, randomized controlled trials 1 Abstract Probiotics for the prevention of necrotizing enterocolitis have attracted a huge interest. Combined data from heterogeneous randomised controlled trials suggest that probiotics may decrease the incidence of NEC. However, the individual studies use a variety of probiotic products, and the group at greatest risk of NEC, i.e. those with a birth weight of less than 1000g, are relatively under-represented in these trials so we do not have adequate evidence of either efficacy or safety to recommend universal prophylactic administration of probiotics to premature infants. These problems have polarized neonatologists, with some taking the view that it is unethical not to universally administer probiotics to premature infants, whereas others regard the meta-analyses as flawed and that there is insufficient evidence to recommend routine probiotic administration. Another problem is that the mechanism by which probiotics might act is not clear, although some experimental evidence is starting to accumulate. This may allow development of surrogate endpoints of effectiveness, refinement of probiotic regimes, or even development of pharmacological agents that may act through the same mechanism.
    [Show full text]
  • Effect of Multi-Strain Probiotic Supplementation on URTI
    nutrients Article Effect of Multi-Strain Probiotic Supplementation on URTI Symptoms and Cytokine Production by Monocytes after a Marathon Race: A Randomized, Double-Blind, Placebo Study Edgar Tavares-Silva 1,2 , Aline Venticinque Caris 2, Samile Amorin Santos 1, Graziela Rosa Ravacci 3 and Ronaldo Vagner Thomatieli-Santos 1,* 1 Department of Bioscience, Universidade Federal de São Paulo, Santos 11015-020, Brazil; [email protected] (E.T.-S.); [email protected] (S.A.S.) 2 Department of Psychobiology, Universidade Federal de São Paulo, São Paulo 04032-020, Brazil; [email protected] 3 Department of Gastroenterology, Medicine Faculty, University of São Paulo, Santos 11015-020, Brazil; [email protected] * Correspondence: [email protected]; Tel.: +55-13-3870-3700 Abstract: (1) Purpose: Performing strenuous exercises negatively impacts the immune and gastroin- testinal systems. These alterations cause transient immunodepression, increasing the risk of minor infections, especially in the upper respiratory tract. Recent studies have shown that supplementation of probiotics confers benefits to athletes. Therefore, the objective of the current study was to verify the effects of probiotic supplementation on cytokine production by monocytes and infections in Citation: Tavares-Silva, E.; the upper respiratory tract after an acute strenuous exercise. (2) Methods: Fourteen healthy male Caris, A.V.; Santos, S.A.; Ravacci, marathon runners received either 5 billion colony forming units (CFU) of a multi-strain probiotic, G.R.; Thomatieli-Santos, R.V. Effect of consisting of 1 billion CFU of each of Lactobacillus acidophilus LB-G80, Lactobacillus paracasei LPc-G110, Multi-Strain Probiotic Lactococcus subp. lactis LLL-G25, Bifidobacterium animalis subp.
    [Show full text]
  • MELATONIN-ND™ Probiotic-Fermented Melatonin Brain, Sleep and Immune Support
    MELATONIN-ND™ Probiotic-Fermented Melatonin Brain, Sleep and Immune Support Melatonin is a unique, complex molecule that is naturally present in virtually every cell of the body. Melatonin is considered to be the global master bioregulator of the whole body, inter-coordinat- ing many of the body’s complex systems, including: ✔ quality sleep ✔ brain support ✔ the immune system ✔ antioxidants ✔ cardiovascular system ✔ neuroendocrine system ✔ bone health The levels of melatonin peak in one’s early years, then as the body ages, the biosynthesis of melatonin begins to decline drastically. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. PREMIER RESEARCH LABS MELATONIN-ND™ is one of nature’s most effective antioxidants, offering A nutritional industry first, featuring melatonin in a unsurpassed protection against a broad range of free convenient liquid form that has been cultured with ben- radicals which can cause cellular damage. eficial probiotic organisms for active bio-availability. Melatonin-ND™ is not animal-derived so it is suitable ARE YOU ENJOYING RESTFUL NIGHTS AND RA- for everyone, including vegetarians and vegans. DIANT DAYS? If you need more help, then PRL’s Melatonin-ND™ is This premier quality formula is fermented using a your product of choice. Experience an industry first unique probiotic culture which allows rapid delivery with probiotic-fermented melatonin that promotes and superior bioenergetic dynamics. Many people say deep, restful, REM sleep. You and your family will feel they can feel the effect of this product the very first the PRL difference! time they take it.
    [Show full text]
  • Myo-Inositol, Probiotics, and Micronutrient Supplementation
    Diabetes Care Volume 44, May 2021 1091 Myo-Inositol, Probiotics, and Keith M. Godfrey,1,2 Sheila J. Barton,1 Sarah El-Heis,1 Timothy Kenealy,3 Micronutrient Supplementation Heidi Nield,1 Philip N. Baker,4 Yap Seng Chong,5,6 Wayne Cutfield,3,7 From Preconception for Glycemia Shiao-Yng Chan,5,6 and NiPPeR Study Group* in Pregnancy: NiPPeR International Multicenter Double-Blind Randomized Controlled Trial Diabetes Care 2021;44:1091–1099 | https://doi.org/10.2337/dc20-2515 OBJECTIVE Better preconception metabolic and nutritional health are hypothesized to pro- mote gestational normoglycemia and reduce preterm birth, but evidence sup- 1MRC Lifecourse Epidemiology Unit, University porting improved outcomes with nutritional supplementation starting of Southampton, Southampton, U.K. CLIN CARE/EDUCATION/NUTRITION/PSYCHOSOCIAL preconception is limited. 2NIHR Southampton Biomedical Research Centre, University Hospital Southampton, NHS RESEARCH DESIGN AND METHODS Foundation Trust, Southampton, Southampton, U.K. This double-blind randomized controlled trial recruited from the community 3Liggins Institute, University of Auckland, 1,729 U.K., Singapore, and New Zealand women aged 18–38 years planning con- Auckland, New Zealand 4 ception. We investigated whether a nutritional formulation containing myo-inosi- College of Life Sciences, Biological Sciences and Psychology, University of Leicester, tol, probiotics, and multiple micronutrients (intervention), compared with a Leicester, U.K. standard micronutrient supplement (control), taken preconception and through- 5Department of Obstetrics and Gynaecology, out pregnancy could improve pregnancy outcomes. The primary outcome was Yong Loo Lin School of Medicine, National combined fasting, 1-h, and 2-h postload glycemia (28 weeks’ gestation oral glu- University of Singapore and National University Health System, Singapore cose tolerance test).
    [Show full text]
  • The Relationship Between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases
    nutrients Review The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases Natalia Arias 1,2,*, Silvia Arboleya 3 , Joseph Allison 2, Aleksandra Kaliszewska 2, Sara G. Higarza 1,4 , Miguel Gueimonde 3 and Jorge L. Arias 1,4 1 Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33003 Oviedo, Asturias, Spain; [email protected] (S.G.H.); [email protected] (J.L.A.) 2 Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, Denmark Hill, London SE5 8AF, UK; [email protected] (J.A.); [email protected] (A.K.) 3 Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33003 Oviedo, Asturias, Spain; [email protected] (S.A.); [email protected] (M.G.) 4 Laboratory of Neuroscience, Department of Psychology, University of Oviedo, Plaza Feijóo, s/n, 33003 Oviedo, Asturias, Spain * Correspondence: [email protected] Received: 14 July 2020; Accepted: 30 July 2020; Published: 5 August 2020 Abstract: Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of choline results in the production of trimethylamine (TMA), which, upon absorption by the host is converted into trimethylamine-N-oxide (TMAO) in the liver. A high accumulation of both components is related to cardiovascular disease, inflammatory bowel disease, non-alcoholic fatty liver disease, and chronic kidney disease. However, the relationship between the microbiota production of these components and its impact on these diseases still remains unknown. In this review, we will address which microbes contribute to TMA production in the human gut, the extent to which host factors (e.g., the genotype) and diet affect TMA production, and the colonization of these microbes and the reversal of dysbiosis as a therapy for these diseases.
    [Show full text]
  • Enterococcus Faecium) Feed Supplementation on Piglet Performance, Intestines Structure, and Antibacterial Activity
    Czech J. Anim. Sci., 62, 2017 (8): 313–322 Original Paper doi: 10.17221/20/2016-CJAS Effect of Glutamine and/or Probiotic (Enterococcus faecium) Feed Supplementation on Piglet Performance, Intestines Structure, and Antibacterial Activity Ewa Hanczakowska1*, Małgorzata Świątkiewicz 2, Małgorzata Natonek-Wiśniewska3, Krzysztof Okoń 4 1Department of Animal Nutrition and Feed Science, National Research Institute of Animal Production, Balice, Poland 2Department of Animal Genetics and Breeding, National Research Institute of Animal Production, Balice, Poland 3Department of Animal Genomics and Animal Molecular Biology, National Research Institute of Animal Production, Balice, Poland 4Department of Pathomorphology, Medical College, Jagiellonian University, Krakow, Poland *Corresponding author: [email protected] ABSTRACT Hanczakowska E., Świątkiewicz M., Natonek-Wiśniewska M., Okoń K. (2017): Effect of glutamine and/or probiotic (Enterococcus faecium) feed supplementation on piglet performance, intestines structure, and antibacterial activity. Czech J. Anim. Sci., 62, 313–322. The effect of glutamine and/or probioticEnterococcus ( feacium) supplements on piglet performance, intestines structure, and microbial status was estimated on 181 piglets (16 litters) of Polish Landrace. The piglets were allo- cated to 2 groups with 8 litters in each, kept in group pens, and fed a standard feed mixture (negative control, group C) or the same mixture supplemented with 2% of glutamine (Group GT). In each group half the animals ® received Cylactin added in the amount of 0.35 × 109 CFU per kg feed. The probiotic consists of dehydrated cells of Enterococcus faecium strain NCIMB 10415. Feed and water were available ad libitum. The piglets were weaned at 28 days of life. At 60 days of life, 6 piglets from each subgroup were slaughtered and their intestines were taken for analysis.
    [Show full text]