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Purebi•Ome™ G.I. Introduced 2014 Product Information Sheet – September 2015 PureBi•Ome™ G.I. Introduced 2014 What Is It? supplementation with 25 billion CFU of this blend provided support for healthy intestinal microflora and G.I. motility. In an 8 week PureBi•Ome™ G.I. combines a clinically-researched, multi-strain randomized, double-blind, placebo-controlled trial, supplementation probiotic blend with l-glutamine to support gastrointestinal (G.I.) with 25 billion CFU of this blend supported abdominal comfort, bowel barrier function, healthy intestinal microflora balance, G.I. comfort function and healthy elimination. Studies suggest that the probiotic and bowel function.* blend also enhances proliferative, phagocytic and secretory capacity Special Features of PureBi•Ome™ of the immune system cells to promote natural defense system function. l-Glutamine is a conditionally essential amino acid utilized • Innovative manufacturing technology effectively combines by the body for tissue repair, G.I. tract support, and natural defense probiotics with other active ingredients for the first time without system function in times of metabolic stress. In a prospective, altering the viability of the probiotic organisms* randomized, double-blind controlled trial involving 20 subjects, - This technology limits the water activity within the probiotic glutamine supplementation supported intestinal integrity and barrier bacterial strains just before the point of tertiary protein function as measured by the lactulose/mannitol test.* structure collapse, allowing the organisms to remain in a quiescent state* Clinical Research • Offers the highly researched consortium of probiotic bacteria* In a randomized placebo-controlled trial involving 52 people supplemented with 25 billion of the PureBi•Ome™ probiotic - Each strain was chosen through a unique process designed to blend or placebo, probiotic supplementation promoted quality identify the strongest and most clinically-effective probiotic of life, G.I. comfort and bowel function; support diminished when strains* supplementation was discontinued. - Scientific and clinical studies have been continuously conducted a) Quality of life on the probiotic blend for over 15 years* Uses For PureBi•Ome™ G.I. Intervention period (weeks) 35 G.I. HEALTH: PureBi•Ome™ G.I. offers 4 clinically-researched probiotic 30 strains Lactobacillus acidophilus (NCIMB 30157), Lactobacillus acidophilus (NCIMB 30156), Bifidobacterium bifidum (NCIMB e 25 Placebo PureBi•Ome™ 30153) and Bifidobacterium lactis (NCIMB 30172), combined with 20 * Strains l-glutamine to support microflora balance and G.I. function. The 15 Change in score formula is designed to enhance G.I. integrity and barrier function Quality of Lif 10 by supporting the protective mucosal lining with a synergistic 5 combination of probiotic organisms and l-glutamine. This probiotic 0 blend is a highly researched 4-strain combination developed through 0 246810 a unique process designed to identify the strongest and most clinically-effective probiotic strains. Research indicates that this blend supports healthy intestinal microflora balance and promotes gastrointestinal health, motility and comfort. In two double-blind, placebo-controlled trials, supplementation with the blend promoted a healthy microflora population in the G.I. tract. In another double- blind, placebo-controlled trial involving 138 elderly individuals, (continued) *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 800-753-2277 | PureEncapsulations.com The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product. Consult your physician for any health problems. 1000-185-REVA Product Information Sheet – September 2015 b) Bloating Recommendations Pure Encapsulations® recommends 1–2 capsules daily, in divided doses, Intervention period (weeks) with a meal. 0 246810 -5 Are There Any Potential Side Effects Or -10 Placebo Precautions? -15 PureBi•Ome™ Strains If pregnant or lactating, consult your physician before taking this -20 product. Probiotics may result in mild flatulence, which should Bloating subside with continued use. They may be contraindicated for use Change in score -25 with immuno-compromised individuals. Consult your physician for -30 more information. -35 Are There Any Potential Drug Interactions? Probiotics may be contraindicated with immuno-suppressant c) Satisfaction with Bowel Habit medications. Consult your physician for more information. Intervention period (weeks) PureBi•Ome™ G.I. 35 each vegetarian capsule contains v 00 30 el Habit probiotic blend ...............................................................................12.5 billion CFU 25 Placebo providing: ow PureBi•Ome™ 20 Lactobacillus acidophilus (NCIMB 30157) Strains * Lactobacillus acidophilus (NCIMB 30156) 15 Bifidobacterium bifidum (NCIMB 30153) Change in score 10 Bifidobacterium lactis (NCIMB 30172) action with B l-glutamine ....................................................................................................... 500 mg 5 other ingredients: hypoallergenic plant fiber (cellulose), potato Satisf 0 maltodextrin, silica, vegetarian capsule (cellulose, water) 0 246810 This formula requires refrigeration to maintain culture viability. 1–2 capsules daily, in divided doses, with meals. d) Gastrointestinal Comfort Intervention period (weeks) 0 246810 -20 t -40 or Placebo -60 PureBi•Ome™ Strains -80 -100 * Change in score -120 otal GI Discomf T -140 * -160 *significant change (p < 0.05) Figure 1. Mean change in scores for (a) quality of life (b) bloating (c) satisfaction with bowel habit (d) gastrointestinal comfort during the 10-week study.* What Is The Source? Lactobacillus acidophilus (NCIMB 30157), Lactobacillus acidophilus (NCIMB 30156), Bifidobacterium bifidum (NCIMB 30153) and Bifidobacterium lactis (NCIMB 30172) are grown on a dairy-free, soy-free medium. l-Glutamine is derived from fermentation of vegetables. Hypoallergenic plant fiber is derived from pine cellulose. Maltodextrin is derived from potato. *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 800-753-2277 | PureEncapsulations.com The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product. Consult your physician for any health problems. 1000-185-REVA.
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