cells Review miR-205: A Potential Biomedicine for Cancer Therapy Neeraj Chauhan 1,2 , Anupam Dhasmana 1,2, Meena Jaggi 1,2, Subhash C. Chauhan 1,2 and Murali M. Yallapu 1,2,* 1 Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA;
[email protected] (N.C.);
[email protected] (A.D.);
[email protected] (M.J.);
[email protected] (S.C.C.) 2 South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA * Correspondence:
[email protected]; Tel.: +1-(956)-296-1734 Received: 3 June 2020; Accepted: 21 August 2020; Published: 25 August 2020 Abstract: microRNAs (miRNAs) are a class of small non-coding RNAs that regulate the expression of their target mRNAs post transcriptionally. miRNAs are known to regulate not just a gene but the whole gene network (signaling pathways). Accumulating evidence(s) suggests that miRNAs can work either as oncogenes or tumor suppressors, but some miRNAs have a dual nature since they can act as both. miRNA 205 (miR-205) is one such highly conserved miRNA that can act as both, oncomiRNA and tumor suppressor. However, most reports confirm its emerging role as a tumor suppressor in many cancers. This review focuses on the downregulated expression of miR-205 and discusses its dysregulation in breast, prostate, skin, liver, gliomas, pancreatic, colorectal and renal cancers. This review also confers its role in tumor initiation, progression, cell proliferation, epithelial to mesenchymal transition, and tumor metastasis.