foods Review Antioxidant and Anti-Inflammatory Properties of Cherry Extract: Nanosystems-Based Strategies to Improve Endothelial Function and Intestinal Absorption Denise Beconcini 1,2,3,* , Francesca Felice 2 , Angela Fabiano 3, Bruno Sarmento 4,5,6 , Ylenia Zambito 3,7 and Rossella Di Stefano 2,7,* 1 Department of Life Sciences, University of Siena, via Aldo Moro 2, 53100 Siena, Italy 2 Cardiovascular Research Laboratory, Department of Surgery, Medical, Molecular, and Critical Area Pathology, University of Pisa, via Paradisa 2, 56100 Pisa, Italy;
[email protected] 3 Department of Pharmacy, University of Pisa, via Bonanno 33, 56100 Pisa, Italy;
[email protected] (A.F.);
[email protected] (Y.Z.) 4 i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, Rua Alfredo Allen 208, 4200-153 Porto, Portugal;
[email protected] 5 INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal 6 CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal 7 Interdepartmental Research Center Nutraceuticals and Food for Health, University of Pisa, via Borghetto 80, 56100 Pisa, Italy * Correspondence:
[email protected] (D.B.);
[email protected] (R.D.S.) Received: 31 December 2019; Accepted: 14 February 2020; Published: 17 February 2020 Abstract: Cherry fruit has a high content in flavonoids. These are important diet components protecting against oxidative stress, inflammation, and endothelial dysfunction, which are all involved in the pathogenesis of atherosclerosis, which is the major cause of cardiovascular diseases (CVD).