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Authors: Pallavi Subhraveti Ingrid Keseler Quang Ong Ron Caspi An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Tim Holland Peter D Karp Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Psyr591153Cyc: Pseudomonas syringae pv. syringae FF5 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari an amino an amino an amino an amino an amino an amino putrescine N,N'-diacetylchitobiose L-arabinose L-arabinose L-arabinose L-arabinose L-arabinose asp spermidine acid acid acid acid acid acid D-mannitol D-xylose D-xylose D-xylose D-xylose D-xylose glutamate sn-glycerol sn-glycerol an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino gln putrescine 2-O-α-mannosyl-D-glycerate β-D-galactose β-D-galactose β-D-galactose β-D-galactose β-D-galactose a polysaccharide a polysaccharide a polysaccharide N,N'- a dicarboxylate D-gluconate D-galactonate D-galactonate D-galactonate acid acid acid acid acid acid acid acid acid acid acid acid acid acid glutamate spermidine 3-phosphate 3-phosphate β β β β β-D-ribopyranose dCTP predicted [+ 5 more] -D-ribopyranose -D-ribopyranose -D-ribopyranose -D-ribopyranose diacetylchitobiose predicted predicted predicted predicted predicted predicted ABC ABC ABC ABC ABC ABC ABC transporter 010100003475 010100022575 010100036179 010100019856 GlpT AraG AraH AraH AraH AraH 010100041832 010100041837 010100021971 010100035169 010100035849 010100035164 010100010096 010100034619 010100002426 010100010581 010100040397 010100010576 transporter transporter transporter 010100040392 010100010571 010100028665 transporter transporter 010100010586 010100031066 010100022795 010100031071 010100022800 010100001514 010100028660 transporter 010100006754 GltP of spermidine/ of an of an of an of an of an of an putrescine amino acid amino acid amino acid amino acid amino acid amino acid K + 010100042332 K + N,N'-diacetylchitobiose 6'-phosphate L-arabinose L-arabinose L-arabinose L-arabinose L-arabinose a polysaccharide a polysaccharide a polysaccharide N,N'- putrescine D-gluconate sn-glycerol sn-glycerol D-galactonate D-galactonate D-galactonate a dicarboxylate an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino gln D-xylose D-xylose D-xylose D-xylose diacetylchitobiose glutamate spermidine D-mannitol 1-phosphate 3-phosphate 3-phosphate D-xylose dCTP α β β β β β acid acid acid acid acid acid acid acid acid acid acid acid acid acid glutamate putrescine 2-O-(6-phospho- -D-mannosyl)-D-glycerate -D-galactose -D-galactose -D-galactose -D-galactose -D-galactose asp K + 010100042347 K + β β β β β an amino an amino an amino an amino an amino an amino spermidine [+ 5 more] -D-ribopyranose -D-ribopyranose -D-ribopyranose -D-ribopyranose -D-ribopyranose acid acid acid acid acid acid K + 010100042342 K + Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Photosynthesis Degradation/Utilization/Assimilation - Other Respiration respiration (anaerobic) K + 010100042367 K + undecaprenyl- undecaprenyl- undecaprenyl- 5,10-methenyl- UDP-N-acetyl- UDP-N-acetyl- D-glycero-D- 4-phospho- guanosine a non-methylated (S)-1-pyrroline- folate reduced riboflavin a nucleoside 2',3'- biotin biosynthesis I photosynthesis light reactions glycogen degradation I Carbohydrate Degradation diphospho-N- diphospho-(N- diphospho-(N- tetrahydropteroyl- α-D-muramoyl- di-trans,octa-cis α-D-muramoyl- di-trans,octa-cis manno-heptose hydroxy-L- 2',3'-cyclic ribosomal cob(II)yrinate a,c-diamide superpathway of tetrahydrofolate biosynthesis superpathay of heme superpathway of heme biosynthesis from uroporphyrinogen-III flavin biosynthesis I (bacteria and plants) chlorophyllide a L-ascorbate biosynthesis V thiamin salvage II L-ascorbate biosynthesis IV tetrahydrofolate salvage from NAD phosphorylation Pentose Phosphate Pathways alginate degradation starch degradation V sucrose degradation II (sucrose synthase) sucrose degradation VII (sucrose 3-dehydrogenase) alkylnitronates degradation cobinamide ATP a tRNA precursor CTP ATP cyclic phosphate 5-carboxylate cob(II)yrinate a,c- [2Fe-2S] iron-sulfur cluster biosynthesis molybdenum cofactor biosynthesis 2-phospho-D-glycerate acrylonitrile degradation I acetylmuramoyl- UDP-N-acetyl- acetylglucosamine) acetylglucosamine)-N- [γ-Glu] L-alanyl-γ-D- -undecaprenyl L-alanyl-γ-D- -undecaprenyl glutamate FAD-dependent pyridine 7-phosphate threonine monophosphate protein L11 trifunctional Amine and Polyamine Biosynthesis (n) bifunctional heptose multifunctional multifunctional ribosomal biosynthesis II (late diamide biosynthesis I biosynthesis from glutamate biosynthesis II (anaerobic) 5,10-methenyltetrahydrofolate and dephosphorylation II bifunctional 5,10- 4-hydroxythreonine- L-alanyl-γ-D- α-D-glucosamine -N-acetylmuramoyl- acetylmuramoyl-L-alanyl- ATP:cob(I)alamin multifunctional glutamyl-L-lysyl- phosphate glutamyl-L- phosphate carboxypeptidase: nucleotide-disulphide tRNA nucleotidyl transcriptional + + cobalt incorporation) β-D-glucose β-D-glucose a small subunit of H O a glycogen methylene-tetrahydrofolate phospho-N- phospho-N- 7-phosphate kinase/ 4-phosphate tRNA nucleotidyl protein L11 K 010100042372 K a malonyl-[acp] (early cobalt insertion) uroporphyrinogen-III hydroxymethylpyrimidine 5,10- phosphopyruvate pentose phosphate pathway (non-oxidative branch) 2 alginate starch sucrose sucrose ethylnitronate undecaprenyldiphospho- + glutamyl-L-lysyl- L-alanyl-γ-D- γ-D-isoglutaminyl- adenosyltransferase: tRNA nucleotidyl D-alanyl-D-alanine lysyl-D-alanine PsyrpsF_010100040999 oxidoreductase:nitrite/ transferase/2'3'-cyclic regulator/proline cys GTP uroporphyrinogen-III 6-phosphate 6-phosphate molybdopterin NAD superpathway of polyamine biosynthesis II acrylonitrile dehydrogenase/ 5,10- acetylmuramoyl- acetylmuramoyl- heptose 1-phosphate dehydrogenase: transferase/2'3'-cyclic methyltransferase: uroporphyrinogen-III glt GTP methenyltetrahydrofolate glycine betaine biosynthesis hydratase: eno glycogen phosphorylase: 2-nitropropane D-alanyl-D-alanine muramoylpentapeptide beta-N- isoglutaminyl-N-(β-D- L-lysyl-(glycyl) - PsyrpsF_010100030831 transferase/2'3'-cyclic sulfite reductase, dehydrogenase/ uroporphyrinogen-III inorganic polyphosphate/ 5 pentapeptide- pentapeptide- glutamate adenyltransferase: PsyrpsF_010100023022 phosphodiesterase/ phosphodiesterase/ prmA uroporphyrin-III C- glutamyl-tRNA uroporphyrinogen uroporphyrinogen hydroxymethylpyrimidine synthase bifunctional 5,10- I (Gram-negative bacteria) D-ribulose PsyrpsF_010100015197 dioxygenase, NPD: acetylglucosaminyltransferase: peptidoglycan methylene-tetrahydrofolate uroporphyrin-III C- ATP-NAD kinase: ppnK Alpha amylase, asparaginyl)-L-lysyl-peptidoglycan D-alanyl-D-alanine cob(I)yrinic acid phosphodiesterase/ transferase: mraY transferase: mraY carboxypeptidase: hemoprotein: PsyrpsF_010100023427 2'nucleotidase/ 2'nucleotidase/ pyrroline-5- a malonyl-[acp] cysteine desulfurase: synthetase: gltX decarboxylase: hemE putative GTP decarboxylase: hemE α-D-glucose kinase: α-D-glucose cys methylene-tetrahydrofolate phosphoenolpyruvate 5-phosphate glycosyltransferase: cyclohydrolase: 4-hydroxythreonine- ribosomal K + 010100042337 K + methyltransferase: methyltransferase: putative GTP arg a plastoquinol [+ 2 isozymes] alginate catalytic region: PsyrpsF_010100001085 murG D-alanyl-D-alanine 2'nucleotidase/ PsyrpsF_010100015714 PsyrpsF_010100003860 phosphatase: cca carboxylate PsyrpsF_010100021076 β dehydrogenase/ 5,10- inorganic polyphosphate/ glycosyltransferase: PsyrpsF_010100030676 a,c-diamide PsyrpsF_010100039301 phosphatase: cca protein L11 methyl ester PsyrpsF_010100008514 PsyrpsF_010100032038 cyclohydrolase: glutamyl-tRNA cyclohydrolase: coproporphyrinogen III 6-phosphate 4-methyl-5-( - 6-phosphate choline PsyrpsF_010100007099 [+ 7 isozymes] acrylamide a peptidoglycan di-trans,octa-cis phosphatase: cca phospho-N- phospho-N- bifunctional heptose 4-phosphate dehydrogenase: PsyrpsF_010100008514 ATP-NAD kinase: ppnK α glycogen degradation II UDP-α-D-glucose 3'-ketosucrose undecaprenyldiphospho- di-trans,octa-cis PsyrpsF_010100030676 adenosyltransferase: [+ 5 isozymes] methyltransferase: PsyrpsF_010100009366 synthetase: gltX coproporphyrinogen III PsyrpsF_010100009366 phosphoglucomutase: hydroxyethyl) phosphoglucomutase: cysteine desulfurase: a carboxy- methylene-tetrahydrofolate ribose-5-phosphate ribulose-phosphate an -limit dextrin alginate lyase: β-D-fructofuranose nitrite a peptidoglycan [+-undecaprenyl 5 isozymes] acetylmuramoyl- acetylmuramoyl- glutamate pteroate 7-phosphate kinase/ dehydrogenase: multifunctional multifunctional 3-oxoacyl-(acyl carrier uroporphyrin-III C- HMP-P + arginine decarboxylase: choline dehydrogenase: pyruvate kinase: phosphoenolpyruvate [+ 7 isozymes] muramoylpentapeptide beta-N- -undecaprenyl dimer (S. aureus) PsyrpsF_010100027643 bifunctional 5,10- putA uroporphyrin-III C- an S-sulfanyl-[L- an L-glutamyl-[tRNA Glu ] coproporphyrinogen cyclohydrolase: NADP isomerase A: 3-epimerase: PsyrpsF_010100036524 amidase family protein: dimer[+ 5 isozymes](E.