Osteonecrosis of the Jaw (ONJ)
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Related Osteonecrosis of the Jaw in Patients with Sjögren's Syndrome
Open access Research BMJ Open: first published as 10.1136/bmjopen-2018-024655 on 13 February 2019. Downloaded from Increased risk of bisphosphonate- related osteonecrosis of the jaw in patients with Sjögren’s syndrome: nationwide population-based cohort study Min-Tser Liao,1,2 Wu-Chien Chien,3,4,5 Jen-Chun Wang,6 Chi-Hsiang Chung,3,4,7 Shi-Jye Chu,8 Shih-Hung Tsai6,9 To cite: Liao M-T, Chien W-C, ABSTRACT Strengths and limitations of this study Wang J-C, et al. Increased Objective The aim of this study was to explore whether risk of bisphosphonate- patients with Sjögren’s syndrome (SS) were susceptible ► The strength of our study is its population-based related osteonecrosis of to bisphosphonate (BP)-related osteonecrosis of the jaw the jaw in patients with cohort design with a large number of patients and (BRONJ) after tooth extraction in the entire population of Sjögren’s syndrome: long-term follow-up, which aims to evaluate the Taiwan. nationwide population-based association between Sjögren’s syndrome and os- Design A nationwide population-based retrospective cohort study. BMJ Open teonecrosis of the jaw (ONJ) after tooth extraction. 2019;9:e024655. doi:10.1136/ cohort study. ► The National Health Insurance Research Database Setting Data were extracted from Taiwan’s National bmjopen-2018-024655 registry could not provide detailed information re- Health Insurance Research Database (NHIRD). Prepublication history and garding laboratory results, family histories and ► Methodology Medical conditions for both the study and additional material for this health-related lifestyle factors. control group were categorised using the International paper are available online. -
Severe Septicaemia in a Patient with Polychondritis and Sweet's
81 LETTERS Ann Rheum Dis: first published as 10.1136/ard.62.1.88 on 1 January 2003. Downloaded from Severe septicaemia in a patient with polychondritis and Sweet’s syndrome after initiation of treatment with infliximab F G Matzkies, B Manger, M Schmitt-Haendle, T Nagel, H-G Kraetsch, J R Kalden, H Schulze-Koops ............................................................................................................................. Ann Rheum Dis 2003;62:81–82 D Sweet first described an acute febrile neutrophilic dermatosis in 1964 characterised by acute onset, fever, Rleucocytosis, and erythematous plaques.1 Skin biopsy specimens show infiltrates consisting of mononuclear cells and neutrophils with leucocytoclasis, but without signs of vasculi- tis. Sweet’s syndrome is frequently associated with solid malig- nancies or haemoproliferative disorders, but associations with chronic autoimmune connective tissue disorders have also been reported.2 The aetiology of Sweet’s syndrome is unknown, but evidence suggests that an immunological reaction of unknown specificity is the underlying mechanism. CASE REPORT A 51 year old white man with relapsing polychondritis (first diagnosed in 1997) was admitted to our hospital in June 2001 with a five week history of general malaise, fever, recurrent arthritis, and complaints of morning stiffness. Besides Figure 1 autoimmune polychondritis, he had insulin dependent Manifestation of Sweet’s syndrome in a patient with relapsing polychondritis. diabetes mellitus that was diagnosed in 1989. On admission, he presented with multiple small to medium, sharply demarked, raised erythematous plaques on both fore- dose of glucocorticoids (80 mg) and a second application of http://ard.bmj.com/ arms and lower legs, multiple acne-like pustules on the face, infliximab (3 mg/kg body weight) were given. -
Dental Management of Patients with Inherited Bleeding Disorders: a Multidisciplinary Approach
Dental management of patients with inherited bleeding disorders: a multidisciplinary approach Hassan Abed, BDS, MSc ¢ Abdalrahman Ainousa, BDS, MSc Bleeding disorders can be inherited or acquired and leeding disorders can result from inherited genetic demonstrate different levels of severity. Dentists may be defects or be acquired due to use of anticoagulant med- called on to treat patients who have bleeding disor- ications or medical conditions such as liver dysfunc- ders such as hemophilia A and von Willebrand disease B 1-3 tion, chronic kidney disease, and autoimmune disease. During (vWD). Dental extraction in any patient with clotting blood vessel injury, hemostasis relies on interactions between factor defects can result in a delayed bleeding episode. the vascular vessel wall and activated platelets as well as clot- 4 Local hemostatic measures provide effective results in ting factors. Any marked defect at one of these stages results a majority of cases but are insufficient in patients with in bleeding disorders. Vascular wall defects, platelet defects, severe hemophilia A and vWD. Therefore, consultation or deficiency of clotting factors can affect the severity level of 5 with the patient’s hematologist is required to ensure bleeding episodes. Thus, patients may have mild, moderate, or preoperative prophylactic coverage. Dental care provid- severe episodes of bleeding. ers have to be aware of any signs of bleeding disorders and refer patients for further medical investigations. This Sources of inherited bleeding disorders article aims to provide dental care providers with the Vascular wall defects knowledge to manage patients with inherited bleeding A patient’s bleeding disorder may be unrecognized, and bleeding disorders, especially hemophilia A and vWD. -
Hypophosphatasia Could Explain Some Atypical Femur Fractures
Hypophosphatasia Could Explain Some Atypical Femur Fractures What we know Hypophosphatasia (HPP) is a rare genetic disease that affects the development of bones and teeth in children (Whyte 1985). HPP is caused by the absence or reduced amount of an enzyme called tissue-nonspecific alkaline phosphatase (TAP), also called bone-specific alkaline phosphatase (BSAP). The absence of TAP raises the level of inorganic pyrophosphate (Pi), which prevents calcium and phosphate from creating strong, mineralized bone. Without TAP, bones can become weak. In its severe form, HPP is fatal and happens in 1/100,000 births. Because HPP is genetic, it can appear in adults as well. A recent study has identified a milder, more common form of HPP that occurs in 4 of 1000 adults (Dahir 2018). This form of HPP is usually seen in early middle aged adults who have low bone density and sometimes have stress fractures in the feet or thigh bone. Sometimes these patients lose their baby teeth early, but not always. HPP is diagnosed by measuring blood levels of TAP and vitamin B6. An elevated vitamin B6 level [serum pyridoxal 5-phosphate (PLP)] (Whyte 1985) in a patient with a TAP level ≤40 or in the low end of normal can be diagnosed with HPP. Almost half of the adult patients with HPP in the large study had TAP >40, but in the lower end of the normal range (Dahir 2018). The connection between hypophosphatasia and osteoporosis Some people who have stress fractures get a bone density test and are treated with an osteoporosis medicine if their bone density results are low. -
• Acute Pericoronitis • End-Stage Renal Disease • Acute Infectious Stomatitis an Acute Apical Abscess Should Not Be a Contraindication to Extraction
• acute pericoronitis • end-stage renal disease • acute infectious stomatitis An acute apical abscess should not be a contraindication to extraction. It has been shown that these infections can resolve very quickly when the affected tooth is removed. However, it may be diffi - cult to extract such a tooth, either because the patient is unable to open sufficiently wide enough or because adequate local anesthesia cannot be obtained. There are few true contraindications to the extraction of teeth. Note: In some instances, the pa - tients’ health may be so compromised that they cannot withstand the surgical procedure. Examples of contraindications include: • End-stage renal disease • Severe uncontrolled metabolic diseases (i.e., uncontrolled diabetes mellitus) • Advanced cardiac conditions (unstable angina) • Patients with leukemia and lymphoma should be treated before extraction of teeth • Patients with hemophilia or platelet disorders should be treated before extraction of teeth • Patients with a history of head and neck cancer need to be treated with care because even minor surgery can lead to osteoradionecrosis. Note: These patients are often treated with hyperbaric oxygen therapy prior to (20 sessions) and following extractions (10 sessions). • Pericoronitis: infection of the soft tissues around a partially erupted mandibular third molar Note: This infection should be treated prior to removal of the maxillary third molar. • Acute infectious stomatitis and malignant disease are relative contraindications • Treatment with IV bisphosphonates increases the risk of osteonecrosis of the jaw Note: Causes of excessive bleeding after dental extractions include: injury to the inferior alveolar artery during extraction of a mandibular tooth (usually the third molar), a muscular arteriolar bleed from a flap procedure, or bleeding related to the patient’s history (i.e., patients who are on warfarin or drugs for platelet inhibition, patients who have hemophilia or von Willebrand disease, or who have chronic liver insufficiency).. -
Therapeutic Alternatives in the Management of Osteoradionecrosis of the Jaws
Med Oral Patol Oral Cir Bucal. 2021 Mar 1;26 (2):e195-207. ORN management Journal section: Oral Surgery doi:10.4317/medoral.24132 Publication Types: Review Therapeutic alternatives in the management of osteoradionecrosis of the jaws. Systematic review Gisela CV Camolesi 1, Karem L. Ortega 2, Janaina Braga Medina 3,4, Luana Campos 5,6, Alejandro I Lorenzo Pouso 7, Pilar Gándara Vila 8, Mario Pérez Sayáns 8 1 DDS. Assistant Professor of Specialization in Oral Maxillofacial Surgery at Foundation for Scientific and Technological Devel- opment of Dentistry, University of São Paulo, Brazil 2 PhD, DDS. Department of Stomatology, School of Dentistry, University of São Paulo, Brazil 3 DDS. Department of Stomatology, School of Dentistry, University of São Paulo, Brazil 4 Division of Dentistry, Mario Covas State Hospital of Santo André, São Paulo, Brazil 5 PhD, DDS. Department of Post-graduation in Implantology, University of Santo Amaro, School of Dentistry. São Paulo, Brazil 6 Oral medicine, Brazilian Cancer Control Institute. São Paulo, Brazil 7 DDS. Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes). Faculty of Medicine and Dentistry Universidade de Santiago de Compostela, Spain 8 PhD, DDS. Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes). Faculty of Medicine and Dentistry Universi- dade de Santiago de Compostela, Spain Correspondence: Entrerríos s/n, Santiago de Compostela C.P. 15782, Spain [email protected] Camolesi GCV, Ortega KL, Medina JB, Campos L, Lorenzo Pouso AI, Gándara Vila P, et al. Therapeutic alternatives in the management of os- Received: 03/07/2020 Accepted: 28/09/2020 teoradionecrosis of the jaws. Systematic review. Med Oral Patol Oral Cir Bucal. -
Dental Management of the Head and Neck Cancer Patient Treated
Dental Management of the Head and Neck Cancer Patient Treated with Radiation Therapy By Carol Anne Murdoch-Kinch, D.D.S., Ph.D., and Samuel Zwetchkenbaum, D.D.S., M.P.H. pproximately 36,540 new cases of oral cavity and from radiation injury to the salivary glands, oral mucosa pharyngeal cancer will be diagnosed in the USA and taste buds, oral musculature, alveolar bone, and this year; more than 7,880 people will die of this skin. They are clinically manifested by xerostomia, oral A 1 disease. The vast majority of these cancers are squamous mucositis, dental caries, accelerated periodontal disease, cell carcinomas. Most cases are diagnosed at an advanced taste loss, oral infection, trismus, and radiation dermati- stage: 62 percent have regional or distant spread at the tis.4 Some of these effects are acute and reversible (muco- time of diagnosis.2 The five-year survival for all stages sitis, taste loss, oral infections and xerostomia) while oth- combined is 61 percent.1 Localized tumors (Stage I and II) ers are chronic (xerostomia, dental caries, accelerated can usually be treated surgically, but advanced cancers periodontal disease, trismus, and osteoradionecrosis.) (Stage III and IV) require radiation with or without che- Chemotherapeutic agents may be administered as an ad- motherapy as adjunctive or definitive treatment.1 See Ta- junct to RT. Patients treated with multimodality chemo- ble 1.3 Therefore, most patients with oral cavity and pha- therapy and RT may be at greater risk for oral mucositis ryngeal cancer receive head and neck radiation therapy and secondary oral infections such as candidiasis. -
Sensitive Teeth.Qxp
Sensitive teeth may be a warning of more serious problems Do You Have Sensitive Teeth? If you have a common problem called “sensitive teeth,” a sip of iced tea or a cup of hot cocoa, the sudden intake of cold air or pressure from your toothbrush may be painful. Sensitive teeth can be experienced at any age as a momentary slight twinge to long-term severe discomfort. It is important to consult your dentist because sensitive teeth may be an early warning sign of more serious dental problems. Understanding Tooth Structure. What Causes Sensitive Teeth? To better understand how sensitivity There can be many causes for sensitive develops, we need to consider the teeth. Cavities, fractured teeth, worn tooth composition of tooth structure. The crown- enamel, cracked teeth, exposed tooth root, the part of the tooth that is most visible- gum recession or periodontal disease may has a tough, protective jacket of enamel, be causing the problem. which is an extremely strong substance. Below the gum line, a layer of cementum Periodontal disease is an infection of the protects the tooth root. Underneath the gums and bone that support the teeth. If left enamel and cementum is dentin. untreated, it can progress until bone and other supporting tissues are destroyed. This Dentin is a part of the tooth that contains can leave the root surfaces of teeth exposed tiny tubes. When dentin loses its and may lead to tooth sensitivity. protective covering and is exposed, these small tubes permit heat, cold, Brushing incorrectly or too aggressively may certain types of foods or pressure to injure your gums and can also cause tooth stimulate nerves and cells inside of roots to be exposed. -
Hereditary Gingival Fibromatosis CASE REPORT
Richa et al.: Management of Hereditary Gingival Fibromatosis CASE REPORT Hereditary Gingival Fibromatosis and its management: A Rare Case of Homozygous Twins Richa1, Neeraj Kumar2, Krishan Gauba3, Debojyoti Chatterjee4 1-Tutor, Unit of Pedodontics and preventive dentistry, ESIC Dental College and Hospital, Rohini, Delhi. 2-Senior Resident, Unit of Pedodontics and preventive dentistry, Oral Health Sciences Centre, Post Correspondence to: Graduate Institute of Medical Education and Research , Chandigarh, India. 3-Professor and Head, Dr. Richa, Tutor, Unit of Pedodontics and Department of Oral Health Sciences Centre, Post Graduate Institute of Medical Education and preventive dentistry, ESIC Dental College and Research, Chandigarh, India. 4-Senior Resident, Department of Histopathology, Oral Health Sciences Hospital, Rohini, Delhi Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Contact Us: www.ijohmr.com ABSTRACT Hereditary gingival fibromatosis (HGF) is a rare condition which manifests itself by gingival overgrowth covering teeth to variable degree i.e. either isolated or as part of a syndrome. This paper presented two cases of generalized and severe HGF in siblings without any systemic illness. HGF was confirmed based on family history, clinical and histological examination. Management of both the cases was done conservatively. Quadrant wise gingivectomy using ledge and wedge method was adopted and followed for 12 months. The surgical procedure yielded functionally and esthetically satisfying results with no recurrence. KEYWORDS: Gingival enlargement, Hereditary, homozygous, Gingivectomy AA swollen gums. The patient gave a history of swelling of upper gums that started 2 years back which gradually aaaasasasss INTRODUCTION increased in size. The child’s mother denied prenatal Hereditary Gingival Enlargement, being a rare entity, is exposure to tobacco, alcohol, and drug. -
Dental Considerations for the Patient with Renal Disease
J Clin Exp Dent. 2011;3(2):e112-9. Patient with renal disease. Journal section: Oral Medicine and Pathology doi:10.4317/jced.3.e112 Publication Types: Review Dental considerations for the patient with renal disease Silvia Martí Álamo 1 , Carmen Gavaldá Esteve 1 , Mª Gracia Sarrión Pérez 1 1 Dentist Correspondence: San Vicente mártir st., 102, 20 46007 Valencia E- mail: [email protected] Received: 05/05/2010 Accepted: 06/12/2010 Martí Álamo S, Gavaldá Esteve C, Sarrión Pérez MG. Dental considera- tions for the patient with renal disease. J Clin Exp Dent. 2011;3(2):e112-9 http://www.medicinaoral.com/odo/volumenes/v3i2/jcedv3i2p112.pdf Article Number: 50304 http://www.medicinaoral.com/odo/indice.htm © Medicina Oral S. L. C.I.F. B 96689336 - eISSN: 1989-5488 eMail: [email protected] Abstract Chronic renal disease (CRD) is the renal disease that manifests oral consequences most frequently, and it is defi- ned as a progressive and irreversible decline in renal function associated with a reduced glomerular filtration rate (GFR). The most frequent causes of CRD are diabetes mellitus, arterial hypertension and glomerulonephritis. CRD is classified in 5 stages – from kidney damage with normal or increased GFR to renal failure. In order to quantify the CRD, renal function is measured using the GFR, which is estimated using creatinine clea- rance (CC). This CC is used for dose adjustment of drugs. In dental practice, the function of the kidneys can be measured indirectly through plasmatic creatinine (Cr), that can be related to the CC using several formulas. The treatment of CRD includes dietary changes, correction of systemic complications, and dialysis or the receipt of a renal graft in severe cases. -
Is the Skeleton Male Or Female? the Pelvis Tells the Story
Activity: Is the Skeleton Male or Female? The pelvis tells the story. Distinct features adapted for childbearing distinguish adult females from males. Other bones and the skull also have features that can indicate sex, though less reliably. In young children, these sex-related features are less obvious and more difficult to interpret. Subtle sex differences are detectable in younger skeletons, but they become more defined following puberty and sexual maturation. What are the differences? Compare the two illustrations below in Figure 1. Female Pelvic Bones Male Pelvic Bones Broader sciatic notch Narrower sciatic notch Raised auricular surface Flat auricular surface Figure 1. Female and male pelvic bones. (Source: Smithsonian Institution, illustrated by Diana Marques) Figure 2. Pelvic bone of the skeleton in the cellar. (Source: Smithsonian Institution) Skull (Cranium and Mandible) Male Skulls Generally larger than female Larger projections behind the Larger brow ridges, with sloping, ears (mastoid processes) less rounded forehead Square chin with a more vertical Greater definition of muscle (acute) angle of the jaw attachment areas on the back of the head Figure 3. Male skulls. (Source: Smithsonian Institution, illustrated by Diana Marques) Female Skulls Smoother bone surfaces where Smaller projections behind the muscles attach ears (mastoid processes) Less pronounced brow ridges, Chin more pointed, with a larger, with more vertical forehead obtuse angle of the jaw Sharp upper margins of the eye orbits Figure 4. Female skulls. (Source: Smithsonian Institution, illustrated by Diana Marques) What Do You Think? Comparing the skull from the cellar in Figure 5 (below) with the illustrated male and female skulls in Figures 3 and 4, write Male or Female to note the sex depicted by each feature. -
Riskwise June 2019
Risk management from Dental Protection RISKISSUE 39 | JUNE 2019 WISEAUSTRALIA The root of the problem or vice versa... Endodontic treatment is an area of dentistry that enjoys more than its fair share of dentolegal risk Iatrogenic injuries Case studies What can be done to avoid them Practical guidance and learning from real life scenarios Editorial DR JAMES FOSTER HEAD OF DENTAL SERVICES AUSTRALASIA/ASIA W ELCOME TO THIS LATEST EDITION OF Australia of increased competition and pricing pressure, it may be RISKWISE, DENTAL PROTECTION’S helpful to reflect upon this. Unfortunately the events of a decade ago in Ireland saw a dramatic increase in the number of claims FLAGSHIP PUBLICATION, WHICH I against colleagues – a substantial number of which were the result HOPE YOU FIND BOTH INFORMATIVE of attempting complex treatments that would have been more appropriate for specialist care, whichever the domain. AND INTERESTING. However, in reflecting on Martin’s text, many of the problems that Feedback we receive from members has consistently shown a strong arise in the field of endodontics can happen even in the best of preference for the case studies with learning points that we include hands. The problem arises with an absence of a documented offer in each edition, and so we have taken this on board and increased the of referral to specialist care, even if refused. A patient’s lawyer may number that we feature – we hope you like the new format. win a case much more readily by proving a breach of duty in relation to the consent process, as opposed to a breach of duty in the actual In this edition, the main article is written by our head of dental treatment provided, which may simply reflect a recognised risk that services for Ireland, Dr Martin Foster, who provides some very helpful the patient has been made aware of.