CONNECTION the Official Newsletter of Zhejiang University Issue 16 Feb.2020
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Treatment with Convalescent Plasma for COVID‐19 Patients in Wuhan
Tangfeng Lv ORCID iD: 0000-0001-7224-8468 Treatment with convalescent plasma for COVID-19 patients in Wuhan, China Mingxiang Ye, MD, PhD Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China Department of Infectious Disease, Unit 4-1, Wuhan Huoshenshan Hospital, Wuhan, China Dian Fu, MD Department of Urology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China Department of Infectious Disease, Unit 4-1, Wuhan Huoshenshan Hospital, Wuhan, China Yi Ren, MD Department of Emergency, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China Department of Infectious Disease, Unit 4-1, Wuhan Huoshenshan Hospital, Wuhan, China This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/jmv.25882. Accepted Article This article is protected by copyright. All rights reserved. Faxiang Wang, MD Department of Emergency, 904 Hospital, Wuxi, China Department of Infectious Disease, Unit 4-1, Wuhan Huoshenshan Hospital, Wuhan, China Dong Wang, MD, PhD Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China Department of Infectious Disease, Unit 4-1, Wuhan Huoshenshan Hospital, Wuhan, China Fang Zhang, MD Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China Department of Infectious Disease, Unit 4-1, Wuhan Huoshenshan Hospital, Wuhan, China Xinyi Xia, MD Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China Department of Laboratory Medicine, Wuhan Huoshenshan Hospital, Wuhan, China Accepted Article This article is protected by copyright. -
China Confronts Covid-19
CHINA CONFRONTS COVID-19 By DAKE KANG and COLLEAGUES Associated Press STORY TK | ASSOCIATED PRESS 1 of 2 CRACKDOWN IN CHINA 1. CHINA DIDN’T WARN PUBLIC OF LIKELY PANDEMIC FOR 6 KEY DAYS April 15, 2020: Top Chinese ofcials secretly determined they were likely facing a pandemic from a new coronavirus in mid-January, ordering preparations even as they downplayed it in public. https://apnews.com/article/68a9e1b91de4fc166acd6012d82c2f9 2. CHINA DELAYED RELEASING CORONAVIRUS INFO, FRUSTRATING WHO June 3, 2020: Even as the World Health Organization publicly praised China, it privately complained about the lack of information it was getting on the new coronavirus. https://apnews.com/article/3c061794970661042b18d5aeaaed9fae 3. CHINA TESTING BLUNDERS STEMMED FROM SECRET DEALS WITH FIRMS Dec. 3, 2020: Secrecy and cronyism crippled China’s testing capacity in the early days of the outbreak, an Associated Press investigation has found. https://apnews.com/article/china-virus-testing-secret-deals-frms- 312f4a953e0264a3645219a08c62a0ad TABLE OF CONTENTS | ASSOCIATED PRESS https://apnews.com/article/68a9e1b91de4fc166acd6012d82c2f9 1 Xie Huanchi/Xinhua via AP Chinese President Xi Jinping talks by video with patients and medical workers at the Huoshenshan Hospital in Wuhan in central China’s Hubei Province in a video released March 10, 2020. April 15, 2020 China didn’t warn public of likely pandemic for 6 key days By ASSOCIATED PRESS Associated Press In the six days after top Chinese ofcials secretly determined they likely were facing a pandemic from a new coronavirus, the city of Wuhan at the epicenter of the disease hosted a mass banquet for tens of thousands of people; millions began traveling through for Lunar New Year celebrations. -
Realizing Constant Current and Constant Voltage Outputs and Input Zero Phase Angle of Wireless Power Transfer Systems with Minimum Component Counts
600 IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS, VOL. 22, NO. 1, JANUARY 2021 Realizing Constant Current and Constant Voltage Outputs and Input Zero Phase Angle of Wireless Power Transfer Systems With Minimum Component Counts Jianghua Lu , Student Member, IEEE, Guorong Zhu , Senior Member, IEEE,DeyanLin,Member, IEEE, Yiming Zhang , Member, IEEE, Haoran Wang , Member, IEEE, and Chunting Chris Mi , Fellow, IEEE Abstract— In both normal and fast wireless electric vehicle advantages of its high specific energy, energy density, and high charging systems, constant current/constant voltage (CC/CV) cycle lifetime. The wireless power transfer (WPT) technology charging profile, regardless of the variation of the battery [1], [2] using magnetic or electric field coupling, namely the state of charge, is one of the most essential characteristics to ensure the battery performance and reliability. The input zero inductive power transfer (IPT) or capacitive power transfer phase angle (ZPA) is able to minimize the system volt-ampere (CPT), provides a promising solution for both normal and fast rating, enhance the power transfer capability, and make it charging [3], [4] of EV Li-ion batteries. Over the full range easy to achieve soft-switching operation over the full range of of the Li-on battery charge, the battery pack equivalent load battery charging profile. Therefore, the load-independent CC and resistance, which defined as the ratio of the charging voltage CV output characteristics with ZPA conditions are necessary for wireless charging systems. However, the existing methods to the charging current, may be roughly from a few ohms to that can achieve these functions either add power switches or several hundred ohms [5]. -
A Chinese Feminist's Reflections on the Pandemic: Gender, Surveillance
1 gender, surveillance& rights onthepandemic: reflections A Chinesefeminist’s CAI YIPING CAI YIPING - JUNE 2020 - TALKS ON COVID - 19 TALKS DAWN DAWN On January 20, 2020 83-year-old Dr Zhong Nanshan solemnly announced on CCTV—on behalf of the National Commission of Health—that the new coronavirus pneumonia (discovered in Wuhan) is transmittable amongst people. After a month had passed, Cai Yiping took a train from Beijing to Tianjin to visit her parents for Chinese New Year—the Spring Festival. She noticed the few passengers travelling on public transport wearing masks and the lack of vehicles and pedestrians in the two cities. The exception, were the patrons queued up to buy festival food at the popular bakeries in preparation for the Spring Festival. Two days before the Chinese New Year, Wuhan was locked down. Movement of people was stopped and confinement measures were soon nationally imposed and it was as if the virus pressed a magic button putting into hibernation 1.4 billion people. Soon after, doctors and nurses across the country were deployed 2 to Wuhan and Hubei provinces as the health workers were on the verge of collapse—a result of the flooding in of patients seeking diagnosis and treatment. By mid-April, it was reported that a total of 42, 600 medical personnel supported Hubei, two-thirds of which were women. 100 days have passed since the lockdown of Wuhan and a glimpse CAI YIPING - JUNE 2020 of hope emerges. Children are now playing in parks, major cities now - witness traffic jams, people are dining out at their favourite restaurants and it seems that life has returned to normal. -
Presentation: IPPR Co-Chairs
World Health Organization Executive Board Special Session October 6, 2020 Update from the Co-Chairs of The Independent Panel for Pandemic Preparedness and Response The Right Honourable Helen Clark, Co-Chair Her Excellency Ellen Johnson Sirleaf, Co-Chair Progress to Date – Key Milestones Resolution 73.1 WHO Director Secretariat Terms of Reference Executive Board adopted by World General appointed established. finalized. Special Session Health Assembly Co-Chairs for the Panelist Independent Panel nominations and Independent Panel for Pandemic comments on draft assembled and held st Preparedness & Terms of Reference. its 1 meeting. Response. Panelists selected May 2020 July 2020 August 2020 September 2020 October 2020 Terms of Reference • The Panel will review experience gained and lessons learned from the international health response to COVID-19 as coordinated by WHO and assess: • (i) the overall relevance and effectiveness of the international health response to the COVID-19 pandemic; WHO IHR Review • (ii) the functioning of the International Health Regulations (2005) and the status of Committee implementation of the relevant recommendations of previous IHR Review Committees; • (iii) the effectiveness of the mechanisms at WHO’s disposal and the actions of WHO and their timelines pertaining to the COVID-19 pandemic; • (iv) WHO’s contribution to United Nations-wide efforts. • In reviewing the experience gained and lessons learned from the WHO-coordinated international health response to COVID-19 as stated in the resolution the Panel will also: • (v) examine global health security threats and provide an analysis of past and future challenges and lessons learned; • (vi) include in its work analysis of the broader impacts of pandemics, including economic and social ones, and make recommendations to the extent that they have a direct bearing on future threats to global health security. -
Potential Factors Influencing Repeated SARS Outbreaks in China
International Journal of Environmental Research and Public Health Review Potential Factors Influencing Repeated SARS Outbreaks in China Zhong Sun 1 , Karuppiah Thilakavathy 1,2 , S. Suresh Kumar 2,3, Guozhong He 4,* and Shi V. Liu 5,* 1 Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, University Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia; [email protected] (Z.S.); [email protected] (K.T.) 2 Genetics and Regenerative Medicine Research Group, Faculty of Medicine & Health Sciences, University Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia; [email protected] 3 Department of Medical Microbiology and Parasitology, University Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia 4 Institute of Health, Kunming Medical University, Kunming 650500, China 5 Eagle Institute of Molecular Medicine, Apex, NC 27523, USA * Correspondence: [email protected] (G.H.); [email protected] (S.V.L.) Received: 28 January 2020; Accepted: 29 February 2020; Published: 3 March 2020 Abstract: Within last 17 years two widespread epidemics of severe acute respiratory syndrome (SARS) occurred in China, which were caused by related coronaviruses (CoVs): SARS-CoV and SARS-CoV-2. Although the origin(s) of these viruses are still unknown and their occurrences in nature are mysterious, some general patterns of their pathogenesis and epidemics are noticeable. Both viruses utilize the same receptor—angiotensin-converting enzyme 2 (ACE2)—for invading human bodies. Both epidemics occurred in cold dry winter seasons celebrated with major holidays, and started in regions where dietary consumption of wildlife is a fashion. Thus, if bats were the natural hosts of SARS-CoVs, cold temperature and low humidity in these times might provide conducive environmental conditions for prolonged viral survival in these regions concentrated with bats. -
Accepted Manuscript
A Tool to Early Predict Severe Corona Virus Disease 2019 (COVID-19) : A Multicenter Study using the Risk Nomogram in Wuhan and Guangdong, China Jiao Gong1*, Jingyi Ou2*, Xueping Qiu3*, Yusheng Jie4,5, Yaqiong Chen1, Lianxiong Yuan6, Jing Cao4, Mingkai Tan2, Wenxiong Xu4, Fang Zheng3+, Yaling Shi2+, Bo Hu1+. 1Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China 2Department of Laboratory Medicine, Guangzhou Eighth People's Hospital, Guangzhou, P.R. China 3Center for Gene Diagnosis, Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China 4Department of Infectious Diseases, Key Laboratory of Liver Disease of Guangdong Province, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China 5Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University Yuedong Hospital, Meizhou, P.R. China 6DepartmentAccepted of Science and Research, Third Manuscript Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China *These authors contributed equally to this work. © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected]. Correspondence: Bo Hu: Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen University, Tianhe Road 600#, Guangzhou, 510630, P.R. China. Phone: +86-20-82179254; Fax: +86-20-85252250. E-mail: [email protected] Summary: Older age, higher LDH, CRP, RDW, DBIL, BUN, and lower ALB on admission correlated with higher odds of severe COVID-19. An effective prognostic nomogram composed of 7 features could allow early identification of patients at risk of exacerbation to severe COVID-19. -
Policy Disparities in Response to the First Wave of COVID-19 Between China and Germany Yuyao Zhang1, Leiyu Shi2, Haiqian Chen1, Xiaohan Wang1 and Gang Sun1,2*
Zhang et al. International Journal for Equity in Health (2021) 20:86 https://doi.org/10.1186/s12939-021-01424-3 RESEARCH Open Access Policy disparities in response to the first wave of COVID-19 between China and Germany Yuyao Zhang1, Leiyu Shi2, Haiqian Chen1, Xiaohan Wang1 and Gang Sun1,2* Abstract Objective: Our research summarized policy disparities in response to the first wave of COVID-19 between China and Germany. We look forward to providing policy experience for other countries still in severe epidemics. Methods: We analyzed data provided by National Health Commission of the People’s Republic of China and Johns Hopkins University Coronavirus Resource Center for the period 10 January 2020 to 25 May 252,020. We used generalized linear model to evaluate the associations between the main control policies and the number of confirmed cases and the policy disparities in response to the first wave of COVID-19 between China and Germany. Results: The generalized linear models show that the following factors influence the cumulative number of confirmed cases in China: the Joint Prevention and Control Mechanism; locking down the worst-hit areas; the highest level response to public health emergencies; the expansion of medical insurance coverage to suspected patients; makeshift hospitals; residential closed management; counterpart assistance. The following factors influence the cumulative number of confirmed cases in Germany: the Novel Coronavirus Crisis Command; large gathering cancelled; real-time COVID-19 risk assessment; the medical emergency plan; schools closure; restrictions on the import of overseas epidemics; the no-contact protocol. Conclusions: There are two differences between China and Germany in non-pharmaceutical interventions: China adopted the blocking strategy, and Germany adopted the first mitigation and then blocking strategy; China’s goal is to eliminate the virus, and Germany’s goal is to protect high-risk groups to reduce losses. -
Coinfection and Other Clinical Characteristics of COVID-19 In
Coinfection and Other Clinical Characteristics of COVID-19 in Children Qin Wu, MD,a,p Yuhan Xing, MD,b,p Lei Shi, MB,a,p Wenjie Li, MS,a Yang Gao, MS,a Silin Pan, PhD, MD,a Ying Wang, MS,c Wendi Wang, MS,a Quansheng Xing, PhD, MDa BACKGROUND AND OBJECTIVES: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is abstract a newly identified pathogen that mainly spreads by droplets. Most published studies have been focused on adult patients with coronavirus disease 2019 (COVID-19), but data concerning pediatric patients are limited. In this study, we aimed to determine epidemiological characteristics and clinical features of pediatric patients with COVID-19. METHODS: We reviewed and analyzed data on pediatric patients with laboratory-confirmed COVID-19, including basic information, epidemiological history, clinical manifestations, laboratory and radiologic findings, treatment, outcome, and follow-up results. RESULTS: A total of 74 pediatric patients with COVID-19 were included in this study. Of the 68 case patients whose epidemiological data were complete, 65 (65 of 68; 95.59%) were household contacts of adults. Cough (32.43%) and fever (27.03%) were the predominant symptoms of 44 (59.46%) symptomatic patients at onset of the illness. Abnormalities in leukocyte count were found in 23 (31.08%) children, and 10 (13.51%) children presented with abnormal lymphocyte count. Of the 34 (45.95%) patients who had nucleic acid testing results for common respiratory pathogens, 19 (51.35%) showed coinfection with other pathogens other than SARS-CoV-2. Ten (13.51%) children had real-time reverse transcription polymerase chain reaction analysis for fecal specimens, and 8 of them showed prolonged existence of SARS-CoV-2 RNA. -
Focus on Scientists Who Tamed Virus
CHINA DAILY | HONG KONG EDITION Monday, December 7, 2020 | 7 CHINA From left: Cao Bin, deputy director of the National Center for Respiratory Medicine, and vice-president of the China-Japan Friendship Hospital in Beijing; Han Qide, academician of the Chinese Academy of Sciences, pathophysiologist and honorary president of the China Association for Science and Technology; Cheng Jing, academician of the Chinese Academy of Engineering and medical biophysicist; Wu Yiling, CAE academician, doctor of traditional Chinese medicine and founder of Shijiazhuang Yiling Pharmaceutical. PHOTOS BY ZHU XINGXIN / CHINA DAILY Zhong Nanshan (left), a prominent respiratory disease expert and CAE academician, chats with Wang Chen, CAE vice- president and president of the Chinese Academy of Medical Sciences , at the opening ceremony of the 2020 Annual Con- gress of the Chinese Thoracic Society in Shenzhen, Guangdong province, on Oct 23. Focus on scientists who tamed virus In this year’s battle to contain COVID19, Chinese medical scientists have always been on the front line and made important contributions. China Daily photographer Zhu Xingxin zooms in on some of the scientists at the forefront of the struggle. Clockwise from left: Huang Jiefu (center), hepatobiliary surgery specialist and director of the China National Organ Donation and Transplantation Committee, at a public event promoting organ donation in Beijing in June. Zeng Yixin, CAS academician, oncologist and deputy director of the National Health Commission; Yang Weizhong, vice-president of the Chinese Preventive Medicine Association and executive president of the School of Population Medicine and Public Health at Peking Union Medical College.. -
1. Sars-Cov Nucleocapsid Protein Epitopes and Uses Thereof
www.engineeringvillage.com Citation results: 500 Downloaded: 4/24/2020 1. SARS-COV NUCLEOCAPSID PROTEIN EPITOPES AND USES THEREOF KELVIN, David; PERSAD, Desmond; CAMERON, Cheryl; BRAY, Kurtis, R.; LOFARO, Lori, R.; JOHNSON, Camille; SEKALY, Rafick-Pierre; YOUNES, Souheil-Antoine; CHONG, Pele Assignee: UNIVERSITY HEALTH NETWORK; BECKMAN COULTER, INC.; UNIVERSITE DE MONTREAL; NATIONAL HEALTH RESEARCH INSTITUTES Publication Number: WO2005103259 Publication date: 11/03/2005 Kind: Patent Application Publication Database: WO Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data Provider: Engineering Village 2. SARS-CoV-specific B-cell epitope and applications thereof Wu, Han-Chung; Liu, I-Ju; Chiu, Chien-Yu Assignee: National Taiwan University Publication Number: US20060062804 Publication date: 03/23/2006 Kind: Utility Patent Application Database: US Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data Provider: Engineering Village 3. A RECOMBINANT SARS-COV VACCINE COMPRISING ATTENUATED VACCINIA VIRUS CARRIERS QIN, Chuan; WEI, Qiang; GAO, Hong; TU, Xinming; CHEN, Zhiwei; ZHANG, Linqi; HO, David, D. Assignee: INSTITUTE OF LABORATORY ANIMAL SCIENCE OF CHINESE ACADEMY OF MEDICAL SCIENCES; THE AARON DIAMOND AIDS RESEARCH CENTER; QIN, Chuan; WEI, Qiang; GAO, Hong; TU, Xinming; CHEN, Zhiwei; ZHANG, Linqi; HO, David, D. Publication Number: WO2006079290 Publication date: 08/03/2006 Kind: Patent Application Publication Database: WO Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data -
Participants: (In Order of the Surname)
Participants 31 Participants: (in order of the surname) Yansong Bai yyyòòòttt: Jilin University, Changchun. E-mail: [email protected] Jianhai Bao ïïï°°°: Central South University, Changsha. E-mail: [email protected] Chuanzhong Chen •••DDD¨¨¨: Hainan Normal University, Haikou. E-mail: [email protected] Dayue Chen •••ŒŒŒ: Peking University, Beijing. E-mail: [email protected] Haotian Chen •••hhhUUU: Jilin University, Changchun. E-mail: [email protected] Longyu Chen •••999ˆˆˆ: Peking University, Beijing. E-mail: [email protected] Man Chen •••ùùù: Capital Normal University, Beijing. E-mail: [email protected] Mu-Fa Chen •••777{{{: Beijing Normal University, Beijing. E-mail: [email protected] Shukai Chen •••ÓÓÓppp: Beijing Normal University, Beijing. E-mail: [email protected] Xia Chen •••ggg: Jilin University, Changchun; University of Tennessee, USA. E-mail: [email protected] Xin Chen •••lll: Shanghai Jiao Tong University, Shanghai. E-mail: [email protected] Xue Chen •••ÆÆÆ: Capital Normal University, Beijing. E-mail: [email protected] Zengjing Chen •••OOO¹¹¹: Shandong University, Jinan. E-mail: [email protected] 32 Participants Huihui Cheng §§§¦¦¦¦¦¦: North China University of Water Resources and Electric Power, Zhengzhou E-mail: [email protected] Lan Cheng §§§===: Central South University, Changsha. E-mail: [email protected] Zhiwen Cheng §§§“““>>>: Beijing Normal University, Beijing. E-mail: [email protected] Michael Choi éééRRRZZZ: The Chinese University of Hong Kong, Shenzhen. E-mail: [email protected] Bowen Deng """ÆÆÆ©©©: Jilin University, Changchun. E-mail: [email protected] Changsong Deng """ttt: Wuhan University, Wuhan. E-mail: [email protected] Xue Ding ¶¶¶ÈÈÈ: Jilin University, Changchun.