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Postgrad Med J: first published as 10.1136/pgmj.43.504.674 on 1 October 1967. Downloaded from 674 Current surveys KIRKLIN, J.W., WALLACE, R.B., MCGOON, D.C. & DUSHANE, Ross, D.N. (1964) Homotransplantation of the aortic valve J.W. (1965) Early and late results after intrecardiac repair in the subcoronary position. J. thorac. cardiov'asc. Surg. of tetralogy of Fallot. Ann. Surg. 162, 578. 47, 713. LILLEHEI, C.W., LEVY, M.J., ADAMS, P. & ANDERSON, R.C. Ross, D.N. (1966) International Medical Tribune of Great (1964) Corrective surgery for tetralogy of Fallot. J. Britain, 30th June. thorac. cardiovasc. Surg. 48, 556. STARR, A. (1966) International Medical Tribune of Great Britain, 30th June. MUSTARD, W.T., KEITH, J.D., TRUSLER, G.A., FOWLER, R. TAYLOR, D.G., THORNTON, J.A., GRAINGER, R.G. & VEREL, & KIDD, L. (1964) Surgical management of transposition D. (1963) Closed pulmonary valvotomy for the relief of of the great vessels. J. thorac. cardiovasc. Surg. 48, 953. Fallot's tetralogy in infancy. J. thorac. cardioiasc. Surg. OCHSNER, J.L., COOLEY, D.A., MCNAMARA, D.G. & KILNE, 46, 77. A. (1962) Surgical treatment of cardiovascular anomalies WATSON, H. & RASHKIND, W.J. (1967) Creation of atrial in 300 infants younger than one year of age. J. thorac. septal defects by balloon catheter in babies with trans- Surg. 43, 182. position of the great arteries. Lancet, i, 403. Respiratory failure and acid-base status in hypothermia M. W. McNICOL M.B., M.R.C.P. Central Middlesex Hospital, London, N.W.10 RESPIRATORY failure is best defined in terms of hypothermic patient and then to consider the ways deviation of arterial blood gas tensions outwith a in which these disturbances may be produced by 'normal' range (Campbell, 1965), commonly by a hypothermia. carbon dioxide tension greater than 50 mmHg and copyright. an oxygen tension less than 60 mmHg. In hypo- Diagnosis of respiratory failure and assessment of thermia the first problem is in defining the 'nor- acid-base status in the hypothermic patient mal' values. This difficulty stems from the fact With fall in temperature the solubility of gases that normal man does not become hypothermic; increases; a liquid at a lower temperature con- the response of patients made hypothermic under tains the same quantity of gas at a lower pressure. anaesthesia reflects anaesthetic techniques almost In blood, with fall in temperature the effects pro- entirely, and the findings in patients with acciden- duced by change in the dissociation constant of tal hypothermia are usually complicated by inter- buffers and displacement to the left of the haemo- current acute respiratory infection. The changes in globin dissociation curve are added to increased http://pmj.bmj.com/ hibernating or poikilothermic animals provide gas solubility. In an anaerobically cooled sample some indication of what the normal pattern may of blood the carbon dioxide content of which is be (Rahn, 1967; Robin, 1962; Lyman & Hastings, constant, carbon dioxide tension falls, plasma 1951), but these are not entirely applicable to man. bicarbonate rises slightly and there is a marked The problems in definition are further complicated rise in pH. Oxygen tension falls, but oxygen by changes in blood gas tensions and pH due to saturation shows no change. The changes in the physical effects of change in temperature. carbon dioxide tension and pH produced in this on September 30, 2021 by guest. Protected It is likely that accidental hypothermia is fre- fashion probably provide the best model for the quently complicated by respiratory failure. 'normal' changes in hypothermia (Brewin et al., McNicol & Smith (1964) found evidence of 1955), but the changes for oxygen do not (see respiratory failure in four of the eight patients below). they studied. The hypoxaemia of respiratory If the normal levels of carbon dioxide tension failure may be an important factor in the high and pH in the hypothermic patient are defined by mortality. Acid-base disturbance is also common, an anaerobically cooled blood sample, assessment the acidosis of carbon dioxide retention being of carbon dioxide tension and pH are greatly found in some patients and in others metabolic simplified, for a blood sample from the patient acidosis associated with fall in plasma bicarbonate measured in an electrode working at its normal probably due to tissue hypoxia from a combina- temperature (37 or 38°C) is anaerobically warmed tion of arterial hypoxaemia and impaired peri- and normality is then defined by normal ranges pheral circulation (Jones et al., 1966). I wish to at electrode working temperature. This seems to discuss first the problems of diagnosis of respira- remain the most useful method of assessment of tory failure and acid-base disturbance in the acid-base and carbon dioxide tension (Patterson Postgrad Med J: first published as 10.1136/pgmj.43.504.674 on 1 October 1967. Downloaded from Current surveys 675 & Sondheimer, 1966). If it is felt to be essential to ture by Severinghaus nomogram. Values should express values at body temperature conversion be not less than normal range at normal tem- factors can be used: for pH +0-0147 pH unit/ perature. degree C temperature fall (Rosenthal, 1948) and for carbon dioxide tension the nomogram of Effect of hypothermia on lung function Severinghaus (1958) which is usually supplied with Hypothermia may affect lung function in the carbon dioxide electrode assemblies. It is doubtful following ways: if any advantage is obtained by these conversions (1) By alteration of the metabolic leads of the unless the exact value of arterial carbon dioxide body-reduction in oxygen consumption and tension is required for the assessment of arterial carbon dioxide excretion. oxygen tension (see below). Treatment of ventila- (2) By alteration in the mechanisms of control tion or acid-base disturbance should be under- of respiration. taken on the measured values at the electrode (3) By alterations in gas solubility and gas temperature. transport. Assessment of arterial oxygen tension presents (4) By change in mechanical or other properties a different problem, for oxygen tension in hypo- of the lung either primarily due to the effects of thermia should be normal or increased. The fall in temperature or secondarily due to other arterial oxygen tension is determined by alveolar changes, e.g. superimposed infection, etc. ventilation and the efficiency of alveolar-arterial oxygen transfer. Carbon dioxide tension is low Alteration of metabolic leads of the body indicating relative alveolar over-ventilation, Under basal conditions oxygen consumption is although absolute ventilatory volumes are re- approximately halved by an 8'C temperature duced. Alveolar oxygen tension is therefore high, drop. Carbon dioxide production is similarly and as hypothermia does not interfere with depressed. Minute volume and alveolar ventilation alveolar-arterial oxygen transfer (Hedley-Whyte are reduced. Data from this laboratory (Kirby & et al., 1965) arterial oxygen tension should be McNicol, unpublished work) in five patients with increased above normal. Values measured at elec- accidental hypothermia, several of whom had copyright. trode temperature are higher than those at body respiratory infection, showed an average minute temperature and should be corrected to body volume of 5-5 litres and alveolar ventilation of temperature using a nomogram similar to that for 2 1/min. Reduction in ventilation is not as great carbon dioxide (Severinghaus, 1958). The 'normal' as a fall in oxygen uptake and carbon dioxide values when so corrected should not be less than excretion; alveolar oxygen tension is therefore the normal values at normal temperature. increased and carbon dioxide tension low. Fall in Clinical assessment of arterial oxygenation by oxygen consumption is accompanied by a smaller examination for cyanosis is particularly mislead- fall in cardiac output, so that venous oxygen http://pmj.bmj.com/ ing because of the shift in the dissociation curve saturation is maintained at normal or slightly in- of haemoglobin which changes the normal re- creased levels (Michenfelder et al., 1965). When lationship between oxygen tension and oxygen shivering occurs oxygen consumption rises with- saturation. Cyanosis does not appear until arterial out change in cardiac output so that venous oxygen tension is very greatly reduced. Measured oxygen saturation falls (Michenfelder et al., 1965). values of oxygen saturation are also misleading The response of ventilation to this extra oxygen unless approximately converted to oxygen tension demand is not known, but the occurrence of fall at body temperature, taking into account the in arterial oxygen saturation in anaesthetized on September 30, 2021 by guest. Protected effects of both temperature and pH; the Severing- hypothermic patients who shiver (Jones & haus nomogram can be used. McLaren, 1965) suggests that the ventilatory response is also inadequate and that the hypo- Summary thermic patient compensates poorly for any extra (1) To assess the acid-base status and adequacy oxygen demand. of ventilation of the hypothermic patient measure arterial blood pH, carbon dioxide tension and Respiratory control bicarbonate, etc., at electrode temperature Experimental hypothermia is usually studied in (37-38'C), express the results at electrode tem- anaesthetized animals and often with controlled perature and use normal values at normal body ventilation. Information on the effects of hypo- temperature for comparison. thermia on respiratory control is therefore scanty. (2) To assess adequacy of arterial oxygenation In one study (Salzano & Hall, 1960), the ventila- measure arterial oxygen tension at electrode tem- tory response to a carbon dioxide load in hypo- perature and convert to patient's body tempera- thermic dogs was found to be diminished, but not Postgrad Med J: first published as 10.1136/pgmj.43.504.674 on 1 October 1967. Downloaded from 676 Current surveys greatly so. There is no evidence on the responses arterial hypoxaemia. Respiratory depression is not to hypoxaemia or acidosis or on any changes in uncommon although its cause is obscure (McNicol reflexes from the lung.
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