RESIDENT SCHOLARLY WORK

Process Improvement 2020-2021 CPIP Curriculum Ongoing Projects:

Alexander Gavralidis, Stephanie tin, Matthew Macey, Allisa Alport, Beenish Furquan, Justin Byrne

• Unnecessary laboratory draws in patients at a Community Hospital - evaluating whether inpatients at Salem Hospital staying overnight for a social reason undergo unnecessary laboratory draws

Daria Ade, Mayuri Rapolu, Usman Mughal, Eva Kubrova, Barbara Lambl, Patrick Lee

• Procalcitonin utilization to tailor antibiotic use at Salem Hospital- part of Antibiotic Stewardship program

Sneha Lakshman, Arturo Castro, Ashley So, George Kavalam, Hassan Kazmi, Daniela Urma, Patrick Gordan

• Development of a standardized ultrasound guided central venus catheter insertion curriculum

Nupur Dandawate, Farideh Davoudi , Usama Talib, Patrick Lee

• Inpatient Echo utilization – guidelines updates

Anneris Estevez, Usmam Mughal, Zach Abbott, Evita Joseph, Caroline Cubbison, Faith Omede, Daniela Urma

• Decrease health disparities for Hispanic community at Lynn NSPG by standardizing diabetes education referral patterns and patient education

Imama Ahmad, Usama Talib, Muhammad Akash, Pablo Ledesma, Patrick Lee • Inpatient Telemetry Utilization

Usman Mughal, Anneris Estevez, Patrick Lee, Barbara Lambl • Health Disparities & Covid-19 Impact on Minorities, sponsored by Dr. Patrick Lee, Chair of Medicine, Dr. Barb Lambl, Infectious Disease

2017-2020

Alexander Gavralidis, Emre Tarhan, Anneris Estevez, Daniela Urma, Austin Turner, Patrick Lee • Expanded Access to Convalescent Plasma for the Treatment of Patients with COVID-19 – 5/2020 implementing use of Convalescent Plasma to MGB Salem hospital in collaboration with research team. Arturo Castro-Diaz, Dr. Daniela Urma • Improving Hospital Care and Post - acute Care of SARS CoV2 patients 4/2020- 8/2020 Caroline Cubbison, Sohaib Ansari, Adam Matos • Code Status Documentation for admitted patients at Salem Hospital - Project accepted to SHM national meeting to be presented in April 2020 Caroline Cubbison, Coleen Reid, Dr. Elizabeth Stevenson, • The Critical Illness Conversation, Dr. Caroline Cubbison, PGY-2, sponsored by Dr. Coleen Reid, Palliative Care, Dr. Elizabeth Stevenson, Critical Care (Journal of Critical Care Medicine, 2020) Faith Omede, Usama Talib, David Cardona • Best project implementation at COE GH Symposium- Introducing an Adapted Critical Response System to a Romanian tertiary Center. December 2019 Sara Altamimi, PGY-2, sponsored by Dr. Marc Rubin, Surgery, Dr. Barb Lambl • C.Difficile Reduction project, Dr. Sara Altamimi, PGY-2, sponsored by Dr. Marc Rubin, Surgery, Dr. Barb Lambl, Infectious Disease (J. of the American Medical Informatics Assoc, 2018; J. of the Joint Commission, 2019) David Cardona, Usama Talib, Elizabeth Stevenson • Therapeutic in , Dr. David Cardona PGY-2, sponsor Dr. Elizabeth Stevenson, Critical Care, 2019

Original Continuing Research 2020-2021

• Stridor retrospective review in patients with COVID: Nupur Dandawate, Sohaib Ansari, Sneha Lakshman, Alexander Gavralidis • Impact on education and wellness in the residency program due to COVID pandemic: Caroline Cubbison, Sneha Lakshman, Imama Ahmad, Nupur Dandawate • Racial and Socioeconomic outcomes in Hispanic population affected by COVID pandemic: Anneris Estevez, Usman Mughal. • Potential Barriers to Clinical Trials of New Therapeutics for Myelodysplastic Syndromes: Alexander Gavralidis • Evaluating relationships between TP53 mutation and the percentage of ring sideroblasts in the bone marrow of patients with MDS. Alexander Gavralidis • Clinicopathological Features of Lung Cancer Patients Treated with Cancer Immunotherapy: Alexander Gavralidis • Co-Founder and Clinical Lead of 'Smart Syringe' through the MGH MESH Incubator - developing a new medical device to automatically detect and document medications from syringes intraoperatively . Ashley So • Cardiovascular Outcomes and Causes of Elevated Troponin in Hospitalized Patients with COVID- 19: Impact on Mortality. Ledesma Pablo •

Published Research

Alexander Gavralidis, Justin Gainor (November 2020). COVID-19 Infection in a Lung Cancer Patient Population: Incidence, Presentation and Alternative Diagnostic Considerations, Retrospective single-institution evaluation of COVID-19 and its implications in patients with lung cancer , JTO Clinical and Research Reports

Alexander Gavralidis, Andrew Brunner (October 2020), Novel Therapies in the Treatment of Adult Acute Lymphoblastic Leukemia, Hematologic Malignancy Reports

Ruta Shah, Ana Maria Bensaci, Patrick Lee, Usman Mughal, caroline Cubbinson, Sophia Chan, Sohaib Ansari, April Susan, Humaira Jami, Mathew Basciota, Jade Gerbands, Vinit Oomen, Alexander Gavralidis, Alba Coraini, 10/21/2020, NEJM, Efficacy of Tocilizumab in Patients Hospitalized with Covid-19. Multi-center RCT including Salem Hospital, MGH, BWH and NWH.

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A. Coraini, S. Lakshman; June 2020; Trick or Treat- A case of seronegative listeria meningoencephalitis; Journal of Neurology and Experimental Neuroscience (JNEN)

Alexander Gavralidis, Justin Gainor, 10/2020. Immunotherapy in EGFR-Mutant and ALK-Positive Lung Cancer: Implications for Oncogene-Driven Lung Cancer. The Cancer Journal

Di Capua, J., Reid, N. J., Som, A., An, T., López, D. B., So, A. J., ... & Walker, G. T. (2020). The Effect of Preoperative Renal Failure on Outcomes Following Infrainguinal Endovascular Interventions for Peripheral Arterial Disease. Journal of Vascular and Interventional Radiology. doi: https://doi.org/10.1016/j.jvir.2020.10.020.

Ledesma Pablo, Gelatin Methacryloyl Bioadhesive Improves Survival and Reduces Scar Burden in a Mouse Model of Myocardial Infarction; Journal of the American Heart Association (JAHA); 05/27/2020; https://doi.org/10.1161/JAHA.119.014199

Kim, S., DeMaria Jr, S., Li, J., Lin, H. M., Smith, N., Wax, D.,A.So & Zerillo, J. (2019). Persistent acidosis after reperfusion—A prognostic indicator of increased 30‐day and in‐hospital postoperative mortality in liver transplant recipients. Clinical transplantation, 33(3), e13473. doi: https://doi.org/10.1111/ctr.13473.

Poster and Oral Presentation

• Estevez, A., Alpert, A., Lee, P. (October 2020). Ten Days of Chest : A Unique Presentation of COVID-19 at a Community Hospital. Presented at Chest Annual Meeting October 2020.

• Ledesma Pablo, November 13-17, 2020 , American Heart Association (AHA) Scientific Sessions Outcomes In Patients Hospitalized With Influenza-related Myocarditis In The United States: A Nationwide Study

• Ledesma Pablo, November 13-17, 2020 , American Heart Association (AHA) Scientific Sessions Trends In Cardiac Implantable Electronic Device-related Infective Endocarditis In The United States: A Nationwide Study (2003-2017)

• Ledesma Pablo, May 6-9, 2020; Heart Rhythm Scientific Sessions (HRS) San Diego, CA, Post-Approval Safety Outcomes of Percutaneous Left Atrial Appendage Closure with Watchman Device: An Analysis of The FDA MAUDE Database From 2015 To 2019

• So Ashley, 2020: Invited Panelist for the workshop "Providers taking control: patient-centered, provider- driven innovation" as part of the 2020 3D All Levels Trauma Care (ALTC) International Conference hosted by the Kingdom of Saudi Arabia's Academy of Science

• Gavralidis Alexander, Daniela Urma (September 2020), Residents drive COVID-19 Convalescent Plasma treatment in a community hospital Research abstract accepted at American College of Physicians, MA • Gavralidis Alexander (September 2020) Intraperitoneal TB – A danger lurking in the dark, Case report accepted at American College of Physicians, MA • Lakshman Sneha L.K.Gomes, J. William (October 2020): American Society of Nephrology, Catch 22: The Vicious Cycle of Malignant and Worsening Renal Thrombotic Microangiopathy

• S. Lakshman, I. Ahmad, R. Kahn CHEST October 2020 Asymmetric Myoclonus in a Patient with Non-Ketotic with baseline End Stage Renal Disease. • S. Lakshman, I. Ahmad, U. Talib. T. Carr; CHEST October 2020; HIT the Heart- A Case of Arterial and Venous Thromboemboli • U. Talib, I. Ahmad, S. Lakshma; CHEST October 2020; Secondary to Ticagrelor: A Rare Complication • Ahmad, S. Lakshman, T. Carr; CHEST October 2020; The Autonomic Storm: A complication of Anoxic Brain Injury • S. Lakshman, S.R. Dassum, and M. Basciotta; ATS May 2020; Dissecting a - a Case of Headache Secondary to Multiple Cerebellar Infarcts in the Setting of a Right Vertebral Artery Dissection • S. Lakshman, U. Talib, E. Stevenson; ATS May 2020; Clots, Clots, Clots! A Case Report of Extensive Arterial Thromboembolic Disease in the Setting of Metastatic Adenocarcinoma of the Lung in an Anti-Coagulated Patient • U. Talib , S. Lakshman; ATS May 2020; Viral Illness Precipitating Cardiac Arrest in a Patient with Congenital QT Prolongation • Coraini, S. Lakshman; Neurological Disorder Summit November 2020; Trick or Treat- A case of seronegative listeria meningoencephalitis • U. Talib, S. Lakshman, S. Ansari, Y. Monzavi, P. Gordan ( 2019) Superior Vena Cava- Right Atrial Junction Endocarditis in HIV Positive Patient with Active IV Drug Use. Circulation 2019; 140: A10105 • S. Lakshman, B. Furquan, M. Basciotta: ACP MA Chapter October 2019; Pyramid - A case of Fever of unknown etiology; Oral Poster Presentation • S. Lakshman, Y. Monzavi, C. Cubbison, M. Basciotta; CHEST October 2019; TB or not TB? A case of Non- tuberculous Mycobacterial Lung Disease • Cardona Estrada, David A. Shafer, K. Opotowsky, A. (May 2019). and Profiles in Adults with Coarctation Of the Aorta. Poster presented at: 29th International Symposium on Congenital Heart Disease in the Adult; Stevenson, WA, USA. • Cardona Estrada, David A., Elantably A. (March 2019). A Case of Primary Undifferentiated Pleomorphic Sarcoma of the Right Ventricle. Poster presented at: American College of Cardiology; New Orleans, LA, USA. • Cardona Estrada, David A. Qazi, S. Roberts, D. (March 2019). Left Ventricular Wall Rupture in a Patient with Rheumatoid Arthritis. Poster presented at: American College of Cardiology; New Orleans, LA, USA. • Elantably, Ahmed. Cardona Estrada, David A. (March 2019). A Case of a Silent PDA Bacterial Endocarditis in Adult. Poster presented at: American College of Cardiology; New Orleans, LA, USA • Jose Mena (Nov 2019). Too hot to handle: A case of non-exertional heat stroke". Presented at SGIM-New England • Adeyinka C. Adejumo National estimate of the frequency, trends, and healthcare burden of care fragmentation in readmissions for End-Stage in the US. Podium presentation at the American Association for the Study of Liver Diseases 2019 meeting, Boston • Adeyinka C. Adejumo Digestive Disease Week, San Diego, May 2019, 1 oral presentation and 2 posters • Adeyinka C. Adejumo Association of Clinical & Translational Science (ACTS), Washington DC, March 2019. 1 oral presentation and 5 posters • Adeyinka C. Adejumo American Gastroenterology Association, annual conference, Philadelphia PA, October 2018

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• Yusef Esparza Monzavi Hodgkin Lymphoma presenting as DVT and pulmonary embolism are associated with aggressive disease and poor prognosis: Report of a case. Presented at SGIM-New England, Nov 2019 • Yunus Emre Tarhan Case of life- threatening bleeding in a Jehovah Witness. Presented at SGIM-New England, Nov 2019 • Usama Talib CHEST 2019:PEMBROLIZUMAB-INDUCED TYPE 1 DIABETES PRESENTING AS DIABETIC KETOACIDOSIS • Usama Talib CHEST 2019:DIABETIC KETOACIDOSIS: A RARE CAUSE OF UNUSUALLY HIGH TROPONIN I LEVEL • Usama Talib CHEST 2019:AIR TRAVEL EMERGENCIES: UNDERSTANDING AND COMBATING • Usama Talib CHEST 2019:HEPARIN-INDUCED HYPERKALEMIA: THE UN-NOTICED SHADOW • Usama Talib. AHA 2019; Superior Vena Cava-Right Atrial Junction Endocarditis in HIV Positive Patient with Active IV Drug Use • Usama Talib AHA 2019; Pembrolizumab Induced Complete Heart Block Associated With Myocarditis • Faith Omede induced hypocortisolemia: A missed diagnosis. Presented at SGIM-New England, Nov 2019 • C. Cubbison, A. Rai1, A. Hyat, D. Cardona, C. Reid, K. McDonald, S. Lakshman, U. Talib, E. Stevenson. What Are Your Hopes and Worries? Can A Palliative Care Curriculum For Residents Increase Rates Of Advanced Care Planning And Decrease Rates Of Intensive Care Unit Transfer And Hospital Length of Stay, Presented at ATS, May 2019 • Caroline Cubbison, MD, Adam Matos, DO, Sohaib Ansari, MD, Ashish Rai, MD, Elizabeth Stevenson, MD, MS, Ellen Arrington, RN, Christine Blaski, MD, A Quality Improvement Initiative to Confirm Code Statuses Accepted for poster presentation, Society of Hospital Medicine, April 2020 • Caroline Cubbison, MD Salma Batool-Anwar, MD, Elizabeth Stevenson, MD Serious Illness Conversations During Medicine Residency: Where Do We Stand and Where Do We Go Next? A National Survey Accepted for presentation, Society of General Internal Medicine • Anneris Estevez Effusion-: Getting to the bottom of a difficult diagnosis. Presented at SGIM-New England, Nov 2019 • Alba Coraini Oral Presentation Small Fiber Peripheral Neuropathy. Presented at: Ipswich Conference Center, Sept 2019 • Alba Coraini A peculiar presentation of altered mental status- When dementia is behind the scene. Presented at SGIM-New England, Nov 2019 • S. Lakshman, Dassum, M. Basciotta, Dissecting a headache: A case of a headache secondary to multiple cerebellar infects in the setting of a Right Vertebral Artery Dissection. SGIM November 2019, ATS 2020 • S. Lakshman, U. Talib, E. Stevenson, Clots, Clots, Clots, Clots! A Case Report of Extensive Arterial Thromboembolic Disease In the setting of Metastatic Adenocarcinoma In An Anticoagulated Patient, ATS 2020 • U. Talib, S. Lakshman, S. Ansari, Y. Monzavi, P. Gordan Superior Vena Cava- Right Atrial Junction Endocarditis in HIV Positive Patient with Active IV Drug Use. AHA 2019 Publication: Circulation 2019; 140:A10105 • S. Lakshman, B. Furquan, M. Basciotta Pyramid fever- A case of Fever of unknown etiology, , ACP MA chapter October 2019 • S. Lakshman, Y. Monzavi, C. Cubbison, M. Bascciotta TB or not TB? A case of Non-tuberculous Mycobacterial Lung Disease. , CHEST October 2019 North Shore Medical Center Publication: Chest Journal Vol. 15, issue 4, A2121 • C. Cubbison, A. Rai, A. Hyat, D. Cardona, C. Reid, K. McDonald, S. Lakshman1 U. Talib, E. Stevenson. What Are Your Hopes and Worries? Can A Palliative Care Curriculum For Residents Increase Rates Of Advanced Care Planning And Decrease Rates Of Intensive Care Unit Transfer And Hospital Length Of Stay? North Shore Medical Center, Brigham and Women’s Hospital Publication: May 2019 C40. Critical Care: The art of War- Innovations in Education, ATS May 2019 • Lakshman, J. Mena, A. Elantably Optimizing Telemetry Utilization Clinical Process Improvement Leadership Program (CPIP) GME . NSMC Poster fair • Cardona Estrada, David A. Alpert A. Hyat A. A Case of Type 1 Cardiorenal Syndrome Secondary to a Large Hepatic Abscess. Abstract Accepted to ACC 2020 • Usama Talib ACC 2020: 2 abstracts accepted • Usama Talib ATS 2020: 4 abstracts accepted • Alba Coraini An unusual presentation of altered mental status: is the answer hidden in the woods or blood? Accepted to the 6th Neurological Disorders Summit (NDS-2020) in San Francisco July 6-8 • Adeyinka C. Adejumo Pancreasfest, annual conference, Pittsburgh, July 2019, 5 abstracts • Estevez, A., Mena, J., Basciotta M. (11/2019). Effusion-Confusion: Getting to the Bottom of a Difficult Diagnosis. Poster presented at: Society of General Internal Medicine (SGIM)/New England region.

Abstracts

• Talib, U., Lakshman S., Estevez A. (Nov. 2020). Propofol and Dexmedetomidine Related Transient High-grade Symptomatic Av Block. Circulation. 2020; 142:A14626 • Estevez, Anneris et al. Ten days of chest pain: a unique presentation of COVID-19 at a community hospital, CHEST, Volume 158, Issue 4, A2545. October 2020. • Lakshman Sneha I. Ahmad, F. Rahaghi, P.G. Czarnecki Clinical Course and Outcomes of AKI Requiring RRT in SARS-CoV-2 ARDS: A Single-Center Retrospective Observational Study - AKI & CRRT 2021 Conference- oral presentation • Ledesma Pablo: Abstract: Outcomes in Patients Hospitalized With Influenza-related Myocarditis in the United States: A Nationwide Study 11/12/2020 https://doi.org/10.1161/circ.142.suppl_3.15390 ; Circulation. 2020;142:A15390 • Ledesma Pablo Abstract: Time-To-Event Analysis of Percutaneous Left Atrial Appendage Closure with Watchman Device: An Analysis of the FDA MAUDE Database from 2015 to 2019; 05/2020; Heart Rhythm Journal https://doi.org/10.1016/j.hrthm.2020.04.007 https://cslide-us.ctimeetingtech.com/hrs20/attendee/eposter/poster/261 • Ledesma Pablo; Abstract: Post-Approval Safety Outcomes of Percutaneous Left Atrial Appendage Closure with Watchman Device: An Analysis of The FDA MAUDE Database From 2015 To 2019; 05/2020; Heart Rhythm Journal https://doi.org/10.1016/j.hrthm.2020.04.007 https://cslide-us.ctimeetingtech.com/hrs20/attendee/eposter/poster/256?s=pn • Ledesma Pablo, Whole exome sequencing in a child with acute disseminated encephalomyelitis, optic neuritis, and periodic fever syndrome: a case report. Journal of Medical Case Reports; 12/2019; https://doi.org/10.1186/s13256-019-2305-3

Awards and Recognitions

• Zachary Abbott; 1st Place – SHM Chapter 1 meeting – November 2020 • Faith Omede, Usama Talib, Best Project Implementation at the COE Global Health Symposium held 12/6/2019 at GME Partners Healthcare • Adeyinka C. Adejumo American Association of Study of Liver Disease (AASLD) Emerging Liver Scholars Award, 2019 • Adeyinka C. Adejumo Collaborative Alliance for Pancreatic Education and Research (CAPER) Academy 6

scholarship award, 2019

• Adeyinka C. Adejumo American Gastroenterology Association (AGA) Early Career Investigator Award, 2019 • Adeyinka C. Adejumo Oral Presentation, Digestive Disease Week, 2019. Title: Relationship between recreational marijuana use and bowel function in a nationwide cohort study 2005-2010 • Adeyinka C. Adejumo Distinguished Oral Presentation, Association of Clinical & Translational Science (ACTS), 2019. Title: Among Hospitalized Patients, Cannabis use is Associated with Reduced risk of Clostridium Difficile infection. Distinguished Oral Presentation, Association of Clinical & Translational Science, 2019. Journal of Clinical and Translational Science 3 (s1), 33-34. • Faith Omede National Institute on Drug Abuse Award to attend the 51st American Association of Addiction Medicine Annual Conference. • Jose Mena, 2019 ASN Kidney STARS award