Cataract Surgery for Natural Rubber Latex Allergic Patients
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Eye (2003) 17, 129–138 & 2003 Nature Publishing Group All rights reserved 0950-222X/03 $25.00 www.nature.com/eye Cataract surgery for D Cheung1 and T Gillow2 REVIEW natural rubber latex allergic patients Abstract In July 2001, the authors were involved in the management of patients undergoing cataract The prevalence of reactions against natural surgery who were known to be NRL sensitive. rubber latex (NRL) is thought to be increasing We discovered that not only did our hospital not in both the general public and healthcare have a formal management plan for NRL- workers. These can vary from mild benign sensitive patients undergoing cataract surgery, skin reactions to bronchospasm, anaphylactic but also that our department was not alone, and shock, and death. Difficulties exist for a brief telephone survey of the theatre sisters of ophthalmic departments wishing to establish other ophthalmic units revealed a similar protocols in providing ‘latex-free situation. Not only were these ophthalmology environments’ for patients undergoing cataract departments lacking a formal protocol of action, surgery. Currently no legislation exists but there was also a general lack of awareness regarding the labelling of NRL-containing amongst ophthalmologists and ophthalmology products in the United Kingdom with nurses to the scale of the problem. information on a product’s NRL content A MEDLINE and EMBASE literature review provided by the manufacturer on a voluntary highlighted several review articles that describe basis only. It is hoped this review article will the magnitude of the problem and basic science act as a basic guide in the management of behind NRL reactions. In addition, many NRL-sensitive patients undergoing cataract subspecialties, in particular dentistry, surgery in the United Kingdom. anaesthesia and otolaryngology, have provided Eye (2003) 17, 129–138. doi:10.1038/ review articles, which act as frameworks for the sj.eye.6700321 management of NRL-related problems within their specific subspecialty. There have been no Keywords: latex hypersensitivity; cataract similar articles specific to cataract surgery as extraction yet. It is hoped that this article will help to address this. Introduction Although it is over 70 years since allergic Case report reactions to natural rubber latex (NRL) were first described,1 a dramatic rise in the number of An 80-year-old woman attended cataract reported cases has occurred over the past two assessment clinic. Her significant past medical 1Birmingham and Midland decades. The majority of these reported cases history included hospital attendance at a Eye Centre have occurred in industrialised countries, and dermatology outpatient clinic for a non-healing Birmingham, UK although it is well known that certain groups of venous calf ulcer. Examination confirmed 2 patients have a higher risk of latex allergy, for visually significant cataracts for which she was North Staffordshire Royal Infirmary example, children with spina bifida, it is listed for surgery. Stoke on Trent, UK believed that the frequency of NRL-induced On the day of surgery, the patient mentioned reactions is increasing in the general population. that she had a ‘rubber allergy’ that had been Correspondence: Reports range from mild mechanical irritant diagnosed by the dermatologist. Although she Mr David Cheung reactions to life-threatening episodes caused by had declared this at the preassessment clinic a Birmingham and Midland immediate IgE-mediated anaphylactic shock. fortnight earlier, there had been no change in Eye Centre Currently, no curative measures to eliminate the course of management of the patient. City Hospital NHS Trust Dudley Road hypersensitivity to NRL proteins exist. All It was realised that during the cataract Birmingham B18 7QU, UK current treatment options revolve around operation, the patient would encounter multiple Tel: + 44 121 554 3801 measures to reduce exposure to NRL proteins.2 types of synthetic/natural types of plastic or E-mail: dmwc@ bigfoot.com Cataract surgery D Cheung and T Gillow 130 rubber—the exact constituents of these were unknown. Epidemiology Several factors were unknown: Natural rubber latex has been in use for over 100 years. It is now estimated that it is found in over 40 000 products. What was the exact allergen to which the patient Although the first allergic reaction to NRL was described was sensitive? over 70 years ago, recently there has been a heightened Whether or not she would be exposed to the allergen? awareness of the problem. This is particularly so in If exposure was inevitable, what was the ‘dose’ subspecialties that have had to cope with the most of exposure? Was this dose of exposure significant? dangerous of complications, for example, hypotension How sensitive would the patient be if she were and sudden anaphylactic shock, airway obstruction and exposed to the allergen? That is, what would be asthma. In the USA, there have been at least 220 cases of the nature/magnitude of hypersensitivity response anaphylaxis due to latex exposure.3 The sensitisation of if significant exposure of allergen occurred? patients to NRL is thought to occur with repeated exposure to NRL proteins, for example, those patients Surgery was deferred until these questions could be who undergo multiple surgical procedures. The answered. increased incidence of NRL allergy in certain high-risk It was later discovered that this lady had attended the groups can be explained by the associated increased vascular surgery outpatient clinic at another hospital for exposure to NRL allergens. For example, it has been a non-healing skin ulcer overlying her left calf, which shown that the risk of latex allergy in a child with spina had been managed unsuccessfully as a mixed arterial bifida increases with the number of operations and venous ulcer. Its treatment consisted of regular performed on that child.4 It is therefore understandable pressure dressings, which were replaced weekly by a that children with spina bifida and multiple orthopaedic community nurse. She was eventually referred to a problems have a higher incidence of NRL allergy. dermatologist for a second opinion and was diagnosed Consequently, much of the current literature regarding with localised dermatitis. Skin patch testing showed the clinical significance of NRL allergy originates from sensitivity to thiuram (rubber) and wool alcohol, and it the subspecialties involved in their care, particularly was advised that all contact with latex be avoided, anaesthetics, intensive therapy unit (ITU) nursing and including the use of both latex-free dressings and gloves orthopaedics.5–11 when dressing the ulcer. The ulcer promptly healed. In addition to high-risk patient groups, there is also an The cataract operation was performed two months increased incidence of NRL-related allergic reactions and later in a ‘latex-free environment’ (see later) without NRL hypersensitivity seen in healthcare workers, for complications. Unaided visual acuity was 6/9, example, dentists, operating nursing staff, accident and improving to 6/6 with a small mixed astigmatic emergency staff,12–14 and this is thought to be due to correction and she was discharged. increased exposure to NRL allergens within the work environment. There have been several controlled studies Discussion to examine the link between NRL allergy and the amount of NRL exposure amongst healthcare workers. Studies on What is latex? The term latex has several meanings NRL allergy amongst dental students have shown a link depending on the context in which it is used. Its with the degree of exposure. First and second year dental definition is necessary to avoid confusion. students studies showed no evidence of NRL allergy. However, levels of NRL allergy increased with the Natural rubber latex is the term used to describe seniority of the students, with 6% of third year students the milk-like sap, which is derived from over and 10% of fourth year students respectively being 2000 species of plants. The most commercially used affected. It was concluded that this pattern was due to species is the common rubber tree Hevea brasiliensis. increasing levels of exposure to NRL allergen as the Synthetic rubber is manufactured from oil-based students progressed through dental school.15 products and is made of multiple synthetic polymers. Even in the lower risk general population, there has When the term latex is used generically, it refers been a dramatic increase in the number of reports of to rubber-like compounds and therefore includes both NRL-induced allergy over the past decade. It is unknown synthetic rubber and NRL-based products. why this should be so, although many researchers have Even more confusingly, medical and scientific articles put forward their putative mechanisms: that use the term to describe a suspension of particles within a liquid, even though the particles The increasing use of disposable NRL-based gloves for themselves are not made of NRL-based compounds surgical and medical procedures because of the or synthetic rubber, for example, latex dyes. increased awareness of cross infection leads to Eye Cataract surgery D Cheung and T Gillow 131 increased exposure to NRL proteins.16–18 Hence the allergens, for example, Hev b 1 is a common allergen in risk of exposure to NRL allergens is higher during children with spina bifida but not for healthcare hospital attendance. workers.32,16 Some of the antigens in NRL are nonspecific The use of gloves by the food processing industry to NRL and may be present in other plants. These are may lead to the introduction of NRL proteins into the frequently enzymes that are present in the H. brasiliensis diet and increased exposure.19 plant and that are also present in other plants such as Some proteins, which cause food allergies, may be endochitinases.33 In vitro diagnostic tests that look for cross-reacting with natural rubber latex allergens. serological evidence of previous exposure NRL must Thus patients with allergies to certain foods, for therefore be specific for NRL antigens only.