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INSIDE THIS ISSUE Link Found Between Common Sexual Infection and • Risk of Aggressive Prostate Cancer • Every Mustache Makes a Difference New Web-Based Us TOO Prostate Cancer Support • Community • Soy Pills Fail to Prevent Bone Loss Men Diagnosed with Prostate Cancer in Recent • Years Have Better Survival Outcomes • Getting Closer to the Origins of Prostate Cancer • Protein Tied with Aggressive Prostate Cancer • 5th Annual Chicago SEA Blue Prostate Cancer Walk Doc Moyad’s “What Works and What Is Worthless • Column”— For BPH, Drugs Are Better than Herbs Estrogen Deficiency Webinar Archive, Transcript • Now Available • The Doctor’s Note — Gerald Chodak, MD Medivation Announces Initiation of Phase 3 Clinical • Trial of MDV3100 in Advanced Prostate Cancer • Letter to the Editor November 2009 LINK FOUND BETWEEN EVERY MOUSTACHE MAKES NEW WEB-BASED US TOO COMMON SEXUAL INFEC- A DIFFERENCE PROSTATE CANCER TION AND RISK OF AGGRES- SUPPORT COMMUNITY SIVE PROSTATE CANCER A new study from Harvard School of Movember is the month formerly Public Health (HSPH) and Brigham known as November where men grow and Women’s Hospital researchers has a moustache for 30 days to raise found a strong association between the awareness and funds to help find a common sexually transmitted infec- cure for prostate and testicular cancer. tion, Trichomonas vaginalis, and risk of advanced and lethal prostate cancer The money raised by Movember in the in men. The study was published US is split between the Prostate Cancer online ahead of print on 9 September Foundation and the Lance Armstrong Us TOO International is pleased to 2009 in the Journal of the National Foundation, so if you want to raise announce the launch of our new online Cancer Institute. Website. funds for research, here’s one way to community, the Us TOO Prostate do it! Visit <www.movember.com> Cancer Support Community, in part- “Prostate cancer is the most common where you’ll find everything you need nership with Inspire. Inspire is a leader cancer among men in western coun- to get started. in building safe and secure online tries, and the second leading cause of Grow a Mo and save a Bro. Ladies can health communities to connect pa- cancer-specific mortality. Identifying tients, families, friends, caregivers and become a Mo Sista! modifiable risk factors for the lethal health professionals for health and form of prostate cancer offers the wellness support. greatest opportunity to reduce suffer- ing from this disease,” said Jennifer The partnership with Inspire allows Us Stark, an HSPH researcher and lead TOO to provide a more comprehensive, author of the study. modern, user-friendly and less costly online community software tool to pro- One potential risk factor is inflamma- vide a safe and secure place for patients tion, which appears to play an impor- and their families to discuss health, tant role in the development and pro- treatment and survivorship issues. gression of prostate cancer, but the source of inflammation of the prostate This new web-based community will is not clear. Trichomonas vaginalis, operate in addition to the long- which infects an estimated 174 million standing Prostate Pointers email dis- cussion lists, and provides new tools people globally each year and is the Tom Kirk, Us TOO President/CEO and most common non-viral sexually trans- Movember Founder Adam Garone need to to find, or offer, information and sup- (Continued on page 3) start clean-shaven on Nov 1 (Continued on page 6) PROSTATE CANCER PATIENT SUPPORT - CALL 1-800-80-US TOO, OR GO TO <WWW.USTOO.ORG> THIS ISSUE OF THE US TOO PROSTATE CANCER SOY PILLS FAIL TO PREVENT BONE LOSS HOTSHEET IS MADE POSSIBLE BY CHARITABLE CONTRIBUTIONS FROM Soy protein extracts showed no evi- age, and CTX levels were much more dence of preventing bone loss in post- predictive of BMD loss, she said. menopausal women in two placebo- The other study, led by Silvina Levis, controlled trials, researchers reported MD, of the University of Miami, here at the American Society for Bone found no effect on a biomarker of and Mineral Research (ASBMR) bone resorption after two years of meeting (Abstract SA0412). treatment with placebo or 200 mg/day AND PEOPLE LIKE YOU! In one trial with 224 participants, very of soy isoflavone pills (Abstract similar declines in lumbar spine and MO0374). ITEMS CONTAINED IN US TOO PUBLICATIONS ARE hip bone mineral density (BMD) were OBTAINED FROM VARIOUS NEWS SOURCES AND EDITED Participants were 248 postmenopausal FOR INCLUSION. WHERE AVAILABLE, A POINT-OF- seen after three years in women taking women, average 53 years old, about CONTACT IS PROVIDED. the soy pills and those taking placebo. two-thirds of whom were Hispanic REFERENCES TO PERSONS, COMPANIES, PRODUCTS OR The other study found that levels of a SERVICES ARE PROVIDED FOR INFORMATION ONLY AND whites. Levis and colleagues reported ARE NOT ENDORSEMENTS. READERS SHOULD CONDUCT biomarker of bone resorption were that levels of urinary N-telopeptide of THEIR OWN RESEARCH INTO ANY PERSON, COMPANY, virtually identical after two years of type I bone collagen (NTx) – like PRODUCT OR SERVICE, AND CONSULT WITH THEIR LOVED high-dose soy extracts versus placebo. ONES AND PERSONAL PHYSICIAN BEFORE DECIDING ON CTX a measure of bone resorption – ANY COURSE OF ACTION. Previous studies had yielded conflict- did not differ between treatment THE INFORMATION AND OPINIONS EXPRESSED IN ing results as to whether the isofla- groups after one and two years of THIS PUBLICATION ARE NOT RECOMMENDATIONS FOR ANY MEDICAL TREATMENT, PRODUCT SERVICE vones in soybeans prevented bone loss. treatment. The study – called SPARE OR COURSE OF ACTION BY US TOO INTERNA- A retrospective Chinese study reported (Soy Phytoestrogen As Replacement TIONAL, INC., ITS OFFICERS AND DIRECTORS, OR THE EDITORS OF THIS PUBLICATION. FOR MEDICAL, in 2005 had found a strong preventive Estrogen) -- also included measure- LEGAL OR OTHER ADVICE, PLEASE CONSULT PROFES- effect in women who had consumed ments of lumbar spine and hip BMD, SIONAL(S) OF YOUR CHOICE. large quantities of soy foods. but those data were not reported here. HOTSHEET EDITORIAL TEAM: “I think we can close the door on this Peter Burckhardt, MD, who studied JONATHAN MCDERMED, PHARMD PAMELA BARRETT issue,” declared the first study’s nutrition and endocrinology at the THOMAS N. KIRK leader, D. Lee Alekel, PhD, of Iowa University Hospital of Lausanne in GEORGE LEDWITH, BOARD REPRESENTATIVE State University in Ames, IA. Alekel Switzerland until his recent retirement, US TOO INTERNATIONAL STAFF & CONSULTANTS: said an earlier study in her own lab said the studies’ findings did not sur- THOMAS N. KIRK, PRESIDENT AND CEO had found a modest benefit in peri- prise him. “The overall evidence in the PAMELA BARRETT, DEVELOPMENT DIRECTOR TERRI GIBBONS, CHAPTER SERVICES PROGRAM menopausal women. But other studies literature is negative,” he said. Burck- MANAGER had either failed to find any benefit for hardt said one of the earlier studies JAQUELINE KONIECZKA, OFFICE MANAGER RYAN MAGUIRE, COMMUNICATIONS COORDINATOR the soy extracts or were marred by that purported to find a benefit was ELIZABETH CABALKA, PROGRAM CONSULTANT small numbers of participants or other misleading. US TOO BOARD OF DIRECTORS: limitations. “[It] was published in a high-ranking EXECUTIVE COMMITTEE/OFFICERS Alekel’s study randomized 224 journal with an attractive title that it FRED MILLS, CHAIRMAN GEORGE LEDWITH, VICE-CHAIRMAN healthy postmenopausal women, mean worked. But when you go into the data CARL FRANKEL, SECRETARY age 54, to take placebo or 80 or 120 you discover that it worked only in a GREGORY BIELAWSKI, TREASURER mg of soy isoflavones in pill form for subgroup and only with a special DAVID P. HOUCHENS, PHD, ASSISTANT TREASURER JO ANN HARDY, MEMBER AT LARGE three years. They also received daily [bone measurement],” he said. Refer- THOMAS N. KIRK, PRESIDENT AND CEO supplements of 500 mg of calcium and ring to the Iowa State study of BMD, DIRECTORS: 600 IU of vitamin D. The researchers Burckhardt said, “It looks solid.” ROBERT FIDOTIN, PHD ran multivariate analyses of BMD Alekel emphasized that the negative TOM HIATT changes that included age, treatments, KAY LOWMASTER, MSW, LCSW results apply only to the soy extracts RICK LYKE, APR whole body fat mass, and the CTX used in the studies. She said soy foods, BILL PALOS biomarker of bone resorption, at three STUART PORTER consumed over a lifetime, could well RIDGE TAYLOR standard sites: lumbar spine, proximal help women limit bone loss and frac- RON WITHERSPOON femur, and femoral neck. tures, just because such foods may be US TOO INTERNATIONAL, INC. IS INCORPORATED Alekel said the analyses showed that less fattening and have other health IN THE STATE OF ILLINOIS AND RECOGNIZED AS A 501(C)(3) NOT-FOR-PROFIT the 120-mg dose of soy was modestly benefits. CHARITABLE CORPORATION. protective at the femoral neck, relative Nevertheless, she said, it now appears to placebo (parameter estimate -1.223, DONATIONS / GIFTS TO US TOO certain that soy phytoestrogens do not ARE TAX DEDUCTIBLE. P=0.024) in women who took at least have the same bone-protective effects 80% of their assigned medications on 5003 FAIRVIEW AVE. DOWNER’S GROVE, IL 60515 at estrogen receptors seen with mam- PHONE: (630) 795-1002 / FAX: (630) 795-1602 schedule. But no significant benefit malian estrogens. WEBSITE: WWW.USTOO.ORG was found for the soy pills in any MedPage Today, 15 September 2009 COPYRIGHT 2009, US TOO INTERNATIONAL, INC. other measure. Whole body fat mass, US TOO PROSTATE CANCER EDUCATION & SUPPORT HOT SHEET - NOVEMBER 2009 P. 2 PROSTATE CANCER PATIENT SUPPORT - CALL 1-800-80-US TOO, OR GO TO <WWW.USTOO.ORG> MEN DIAGNOSED WITH PROSTATE CANCER IN RECENT T VAGINALIS INFECTION YEARS HAVE BETTER SURVIVAL OUTCOMES (Continued from page 1) Research published online ahead of to 15 to 23 percent in the earlier period.

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