An Approach to Interpreting Spirometry TIMOTHY J
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Effect of an Indwelling Pleural Catheter Vs Talc Pleurodesis On
This supplement contains the following items: 1. Original protocol, final protocol, summary of changes. 2. Original statistical analysis plan. There were no further changes to the original statistical analysis plan. Downloaded From: https://jamanetwork.com/ on 10/02/2021 The Australasian Malignant Pleural Effusion Trial (AMPLE) A Multicentre Randomized Study Comparing Indwelling Pleural Catheter vs Talc Pleurodesis in Patients with Malignant Pleural Effusions Ethics Registration number 2012-005 Protocol version number 1.0 Protocol date 10/01/2012 Authorised by: Name: Prof YC Gary Lee Role: Chief Investigator Signature: Date: 10/01/2012 Downloaded From: https://jamanetwork.com/ on 10/02/2021 General Information This document describes the Western Australian Randomised Malignant Effusion trial for the purpose of submission for review by the relevant human research and ethics committees. It provides information about procedures for entering patients into the trial and this protocol should not be used as a guide for the treatment of other patients; every care was taken in its drafting, but corrections or amendments may be necessary. Questions or problems relating to this study should be referred to the Chief Investigator or Trial Coordinator. Compliance The trial will be conducted in compliance with this protocol, the National Statement on Ethical Conduct in Human Research, data protection laws and other guidelines as appropriate. It will be registered with the Australia and New Zealand Clinical Trials Registry, once ethical approval is secured. -
Effect of Heliox Breathing on Flow Limitation in Chronic Heart Failure Patients
Eur Respir J 2009; 33: 1367–1373 DOI: 10.1183/09031936.00117508 CopyrightßERS Journals Ltd 2009 Effect of heliox breathing on flow limitation in chronic heart failure patients M. Pecchiari*, T. Anagnostakos#, E. D’Angelo*, C. Roussos#, S. Nanas# and A. Koutsoukou# ABSTRACT: Patients with chronic heart failure (CHF) exhibit orthopnoea and tidal expiratory flow AFFILIATIONS limitation in the supine position. It is not known whether the flow-limiting segment occurs in the *Istituto di Fisiologia Umana I, Universita` degli Studi di Milano, peripheral or central part of the tracheobronchial tree. The location of the flow-limiting segment Milan, Italy, and can be inferred from the effects of heliox (80% helium/20% oxygen) administration. If maximal #Dept of Critical Care and Pulmonary expiratory flow increases with this low-density mixture, the choke point should be located in the Services, Evangelismos General central airways, where the wave-speed mechanism dominates. If the choke point were located in Hospital, Medical School, University of Athens, Athens, Greece. the peripheral airways, where maximal flow is limited by a viscous mechanism, heliox should have no effect on flow limitation and dynamic hyperinflation. CORRESPONDENCE Tidal expiratory flow limitation, dynamic hyperinflation and breathing pattern were assessed in M. Pecchiari 14 stable CHF patients during air and heliox breathing at rest in the sitting and supine position. Istituto di Fisiologia Umana I via L. Mangiagalli 32 No patient was flow-limited in the sitting position. In the supine posture, eight patients exhibited 20133 Milan tidal expiratory flow limitation on air. Heliox had no effect on flow limitation and dynamic Italy hyperinflation and only minor effects on the breathing pattern. -
Peak Flow Measure: an Index of Respiratory Function?
International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article Peak Flow Measure: An Index of Respiratory Function? D. Devadiga, Aiswarya Liz Varghese, J. Bhat, P. Baliga, J. Pahwa Department of Audiology and Speech Language Pathology, Kasturba Medical College (A Unit of Manipal University), Mangalore -575001 Corresponding Author: Aiswarya Liz Varghese Received: 06/12/2014 Revised: 26/12/2014 Accepted: 05/01/2015 ABSTRACT Aerodynamic analysis is interpreted as a reflection of the valving activity of the larynx. It involves measuring changes in air volume, flow and pressure which indicate respiratory function. These measures help in determining the important aspects of lung function. Peak expiratory flow rate is a widely used respiratory measure and is an effective measure of effort dependent airflow. Aim: The aim of the current study was to study the peak flow as an aerodynamic measure in healthy normal individuals Method: The study group was divided into two groups with n= 60(30 males and 30 females) in the age range of 18-22 years. The peak flow was measured using Aerophone II (Voice Function Analyser). The anthropometric measurements such as height, weight and Body Mass Index was calculated for all the participants. Results: The peak airflow was higher in females as compared to that of males. It was also observed that the peak air flow rate was correlating well with height and weight in males. Conclusions: Speech language pathologist should consider peak expiratory airflow, a short sharp exhalation rate as a part of routine aerodynamic evaluation which is easier as compared to the otherwise commonly used measure, the vital capacity. -
Spirometry Basics
SPIROMETRY BASICS ROSEMARY STINSON MSN, CRNP THE CHILDREN’S HOSPITAL OF PHILADELPHIA DIVISION OF ALLERGY AND IMMUNOLOGY PORTABLE COMPUTERIZED SPIROMETRY WITH BUILT IN INCENTIVES WHAT IS SPIROMETRY? Use to obtain objective measures of lung function Physiological test that measures how an individual inhales or exhales volume of air Primary signal measured–volume or flow Essentially measures airflow into and out of the lungs Invaluable screening tool for respiratory health compared to BP screening CV health Gold standard for diagnosing and measuring airway obstruction. ATS, 2005 SPIROMETRY AND ASTHMA At initial assessment After treatment initiated and symptoms and PEF have stabilized During periods of progressive or prolonged asthma control At least every 1-2 years: more frequently depending on response to therapy WHY NECESSARY? o To evaluate symptoms, signs or abnormal laboratory tests o To measure the effect of disease on pulmonary function o To screen individuals at risk of having pulmonary disease o To assess pre-operative risk o To assess prognosis o To assess health status before beginning strenuous physical activity programs ATS, 2005 SPIROMETRY VERSUS PEAK FLOW Recommended over peak flow meter measurements in clinician’s office. Variability in predicted PEF reference values. Many different brands PEF meters. Peak Flow is NOT a diagnostic tool. Helpful for monitoring control. EPR 3, 2007 WHY MEASURE? o Some patients are “poor perceivers.” o Perception of obstruction variable and spirometry reveals obstruction more severe. o Family members “underestimate” severity of symptoms. o Objective assessment of degree of airflow obstruction. o Pulmonary function measures don’t always correlate with symptoms. o Comprehensive assessment of asthma. -
BSL Lesson 13
Physiology Lessons Lesson 13 for use with the PULMONARY FUNCTION II Biopac Student Lab Pulmonary Flow Rates Forced Expiratory Volume (FEV1,2,3) PC under Windows 95/98/NT 4.0/2000 Maximal Voluntary Ventilation (MVV) or Macintosh Manual Revision 12132000.PL3.6.6-ML3.0.7 Number of cycles in 12 second interval Average Volume Richard Pflanzer, Ph.D. per cycle Associate Professor Indiana University School of Medicine Purdue University School of Science J.C. Uyehara, Ph.D. Biologist Number of cycles/minute = Number of cycles in 12 second interval X 5 MVV = (Average volume per cycle) X (Number of cycles per minute) BIOPAC Systems, Inc. William McMullen Vice President BIOPAC Systems, Inc. BIOPAC Systems, Inc. 42 Aero Camino, Santa Barbara, CA 93117 (805) 685-0066, Fax (805) 685-0067 Email: [email protected] Web Site: http://www.biopac.com Page 2 Lesson 13: Pulmonary Function II Biopac Student Lab V3.0 I. INTRODUCTION The respiratory or pulmonary system performs the important functions of supplying oxygen (O2) during inhalation, removing carbon dioxide (CO2) during exhalation, and adjusting the acid-base balance (pH) of the body by removing acid-forming CO2. Because oxygen is necessary for cellular metabolism, the amount of air that the pulmonary system provides is important in setting the upper limits on work capacities or metabolism. Therefore, the measurement of lung volumes and the rate of air movement (airflow) are important tools in assessing the health and capacities of a person. In this lesson, you will measure: Forced Vital Capacity (FVC), which is the maximal amount of air that a person can forcibly exhale after a maximal inhalation. -
Restrictive Lung Disease
Downloaded from https://academic.oup.com/ptj/article/48/5/455/4638136 by guest on 29 September 2021 RESTRICTIVE LUNG DISEASE WARREN M. GOLD, M.D. RESTRICTIVE LUNG DISEASE is a These disorders can be divided into two pattern of abnormal lung function defined by groups: extrapulmonary and pulmonary. a decrease in lung volume (Fig. I).1,2 The In extrapulmonary restriction, an abnormal total lung capacity is decreased and, in severe increase in the stiffness of the chest wall (kypho restrictive defects, all of the subdivisions of the scoliosis) restricts the lung volumes, as does total lung capacity including vital capacity, respiratory muscle weakness (poliomyelitis or functional residual capacity, and residual vol muscular dystrophy). These extrapulmonary ume are decreased. In mild or moderately se causes of pulmonary restriction are treated vere restrictive defects, the residual volume may be normal or slightly increased. CLINICAL DISORDERS CAUSING TABLE 1 RESTRICTIVE LUNG DISEASE CAUSES OF RESTRICTIVE LUNG DISEASE Restrictive lung disease is not a specific clin I. Extrapulmonary restriction 3 ical entity, but only one of several patterns of A. Chest wall stiffness (kyphoscoliosis) B. Respiratory-muscle weakness (muscular dystrophy)4 abnormal lung function. It is produced by a C. Pleural disease (pneumothorax)5 number of clinical disorders (see Table 1). II. Pulmonary restriction A. Surgical resection (pneumonectomy)6.7 Dr. Gold: Director, Pulmonary Laboratory and Re B. Tumor (bronchogenic carcinoma or metastatic tumor)8 search Associate in Cardiology (Pulmonary Physiology), C. Heart disease (hypertensive, arteriosclerotic, rheu Children's Hospital Medical Center; Associate in Pedi matic, congenital)9 atrics and Tutor in Medical Science, Harvard Medical 10 11 School, Boston, Massachusetts. -
Methacholine Challenge Test 1 2
Methacholine Challenge Test 1 2 What is Methacholine Challenge Test (MCT)? Also, • Do not consume a heavy meal within 2 hours of the test. You can have a light It is a test that measures if your airways narrow after inhaling specific provoking meal e.g. sandwich, soup or salad within 2 hours before the test. agent. The provoking agent used in this test is inhaled methacholine. The degree • Do not wear any tight clothes. of resultant airway narrowing is dependent on each individual’s susceptibility and this airway narrowing will be assessed objectively by measuring the lung function You may also need to stop certain medications before taking the test depending on what clinical questions your physician would like answered based on your MCT changes before and after inhalation of the methacholine in progressively larger results. Different medications have to be stopped at different times before the test doses. Increased airway hyperresponsiveness is usually a hallmark feature of asthma. depending on how long they stay in your body. It is important for you to check with your doctor regarding the safety of stopping Why do I need this operation/procedure? these medications before discontinuing them for the test. Commonly, if you had presented with respiratory symptoms such as shortness of How long before the test? Avoid the following: breath, wheezing, chest tightness or cough, 6weeks Omalizumab your physician may consider doing a MCT to 1week Tiotropium (Spiriva) establish the diagnosis of asthma, especially if 48hours Combination inhalers such as Seretide (fluticasone/ initial lung function tests have not confirmed salmeterol) or Symbicort (budesonide/formoterol) or the diagnosis. -
Standardisation of Spirometry
Eur Respir J 2005; 26: 319–338 DOI: 10.1183/09031936.05.00034805 CopyrightßERS Journals Ltd 2005 SERIES ‘‘ATS/ERS TASK FORCE: STANDARDISATION OF LUNG FUNCTION TESTING’’ Edited by V. Brusasco, R. Crapo and G. Viegi Number 2 in this Series Standardisation of spirometry M.R. Miller, J. Hankinson, V. Brusasco, F. Burgos, R. Casaburi, A. Coates, R. Crapo, P. Enright, C.P.M. van der Grinten, P. Gustafsson, R. Jensen, D.C. Johnson, N. MacIntyre, R. McKay, D. Navajas, O.F. Pedersen, R. Pellegrino, G. Viegi and J. Wanger CONTENTS AFFILIATIONS Background ............................................................... 320 For affiliations, please see Acknowledgements section FEV1 and FVC manoeuvre .................................................... 321 Definitions . 321 CORRESPONDENCE Equipment . 321 V. Brusasco Requirements . 321 Internal Medicine University of Genoa Display . 321 V.le Benedetto XV, 6 Validation . 322 I-16132 Genova Quality control . 322 Italy Quality control for volume-measuring devices . 322 Fax: 39 103537690 E-mail: [email protected] Quality control for flow-measuring devices . 323 Test procedure . 323 Received: Within-manoeuvre evaluation . 324 March 23 2005 Start of test criteria. 324 Accepted after revision: April 05 2005 End of test criteria . 324 Additional criteria . 324 Summary of acceptable blow criteria . 325 Between-manoeuvre evaluation . 325 Manoeuvre repeatability . 325 Maximum number of manoeuvres . 326 Test result selection . 326 Other derived indices . 326 FEVt .................................................................. 326 Standardisation of FEV1 for expired volume, FEV1/FVC and FEV1/VC.................... 326 FEF25–75% .............................................................. 326 PEF.................................................................. 326 Maximal expiratory flow–volume loops . 326 Definitions. 326 Equipment . 327 Test procedure . 327 Within- and between-manoeuvre evaluation . 327 Flow–volume loop examples. 327 Reversibility testing . 327 Method . -
Expiratory Capnography in Asthma
Eur Respir J, 1994, 7, 318–323 Copyright ERS Journals Ltd 1994 DOI: 10.1183/09031936.94.07020318 European Respiratory Journal Printed in UK - all rights reserved ISSN 0903 - 1936 Expiratory capnography in asthma: B. You*, R. Peslin**, C. Duvivier**, V. Dang Vu*, J.P. Grilliat* Expiratory capnography in asthma: evaluation of various shape indices. B. You, R. *U.M.G., Service de Médecine H, Hôpital Peslin, C. Duvivier, V. Dang Vu, J.P. Grilliat. ERS Journals Ltd 1994. Central, Nancy, France. **INSERM, Unité ABSTRACT: The shape of the capnogram is modified by airway obstruction, and 14, Physiopathologie Respiratoire, Vandœuvre- the evaluation of this deformation, using measurable indices, could allow an indi- les- Nancy, France. rect measurement of bronchial patency. A previous study undertaken in asthmat- Correspondence: B. You ic subjects showed a good correlation between a capnographic index (end-tidal slope) 19 Avenue du Vieux Château and a spirometric parameter (forced expiratory volume in one second as a per- Vandœuvre-les-Nancy centage of predicted (FEV1 %pred)) and suggested the study of other indices. 54500 The correlations between capnographic and spirometric indices were measured France in 10 healthy subjects and 30 asthmatic patients. The usefulness of eight descriptive indices, analysing the successive phases of the capnogram, was assessed by measur- Keywords: Asthma ing their reproducibility and their sensitivity to airway obstruction. The intra- capnography individual and interindividual variabilities (Vi and VI) and the noise/signal ratio carbon dioxide lung function tests (Vi/VI) were measured by comparing the results of two successive capnographic monitoring measurements in 14 asthmatic subjects. -
Study of Pleurodesis Using Ethanolamine Oleate Through Ultrasound-Guided Pigtail Adel M
Original article 253 Study of pleurodesis using ethanolamine oleate through ultrasound-guided pigtail Adel M. Saeeda, Tamer M. Alia, Ashraf A. Gomaaa, Mohamed N. Kamelb Background Malignant pleural effusion (MPE) is a common treatment, the management of MPE remains palliative, with and serious condition that is associated with poor quality of median survival ranging from 3 to 12 months. life, morbidity and mortality. Results Complete response was 81.8% of studied cases, Aim Study of pleurodesis using ethanolamine oleate (ETH) while no/partial response was 18.2%. Pleurodesis through ultrasound-guided pigtail to evaluate the efficacy and complications were fever (21.1%), chest pain (33.3%), complications of ETH and pigtail. nausea (24.2%), vomiting (12.1%) and hypotension (6.1%). Pigtail complications were pigtail obstruction (3.03%), chest Design Thirty-three patients with MPE were included and pain (3.03%) and obstruction and pain (12.12%) of the were subjected to history taking, clinical examination, chest studied cases. There was a decrease in FVC% and FEV1% 2 radiographs (on admission, every day before pleurodesis to months after pleurodesis. However, no significant difference ensure complete lung expansion and to exclude as regards actual (measured) FEV1/FVC% before and 2 pneumothorax, every day after pleurodesis till the removal of months after pleurodesis in all cases. Whereas, complete the catheter and on follow-up − 2 months after pleurodesis − response was 81.8% by CXR and chest ultrasound. to check for reaccumulation of pleural effusion), chest sonography, pleural tapping, chest computed tomography Conclusion ETH injection through pigtail was safe and scan (in some patients), pleural biopsy using Abram’s needle effective in pleurodesis of MPE. -
ERS Technical Standard on Bronchial Challenge Testing: Pathophysiology and Methodology of Indirect Airway Challenge Testing
ERJ Express. Published on October 25, 2018 as doi: 10.1183/13993003.01033-2018 Early View Task force report ERS Technical Standard on Bronchial Challenge Testing: Pathophysiology and Methodology of Indirect Airway Challenge Testing Teal S. Hallstrand, Joerg D. Leuppi, Guy Joos, Graham L. Hall, Kai-Håkon Carlsen, David A. Kaminsky, Allan L. Coates, Donald W. Cockcroft, Bruce H. Culver, Zuzana Diamant, Gail M. Gauvreau, Ildiko Horvath, F. H. C. de Jongh, Beth L. Laube, P. J. Sterk, Jack Wanger Please cite this article as: Hallstrand TS, Leuppi JD, Joos G, et al. ERS Technical Standard on Bronchial Challenge Testing: Pathophysiology and Methodology of Indirect Airway Challenge Testing. Eur Respir J 2018; in press (https://doi.org/10.1183/13993003.01033-2018). This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Copyright ©ERS 2018 Copyright 2018 by the European Respiratory Society. ERS Technical Standard on Bronchial Challenge Testing: Pathophysiology and Methodology of Indirect Airway Challenge Testing. Teal S. Hallstrand1, Joerg D. Leuppi2, Guy Joos3, Graham L. Hall4, Kai-Håkon Carlsen5, David A. Kaminsky6, Allan L. Coates7, Donald W. Cockcroft8, Bruce H. Culver1, Zuzana Diamant9,10, Gail M. Gauvreau11, Ildiko Horvath12, F.H.C. de Jongh13, -
Pulmonary Function Test (PFT)
Pulmonary Function Test (PFT) St. James Mercy Hospital Respiratory Therapy, 1st Floor 411 Canisteo St. Hornell, NY 14843 607-324- 8159 To schedule an appointment: 607-324-2879 To fax to scheduling: 607-324-8221 What is pulmonary function testing and why is it done? Pulmonary function tests (also called PFTs or lung function tests) help determine how well your lungs are functioning. The results of these tests tell your physician how much air your lungs can hold, how quickly you can move air into and out of your lungs, and how well your lungs are able to use oxygen and get rid of carbon dioxide. The tests help your physician determine if you have a lung disease, help provide a measure of how significant your lung disease is, and can show how well the treatment for your lung disease is working. How is a pulmonary function test done? Pulmonary function testing is usually done by a specially trained respiratory therapist or technician. For most pulmonary function tests, you will be asked to wear a nose clip to make sure that no air passes through your nose during the test. You will be asked to breathe into a mouthpiece that is connected to a machine called a spirometer. The technician may encourage you to breathe deeply during parts of the test to get the best results. Following all of the technician's instructions will help provide the most accurate results. How do I prepare for my test? You should not eat a heavy meal just before this test. You should not smoke for six hours before the test.