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HMF Probiotics PROFESSIONAL PRODUCT GUIDE

HMF Probiotics PROFESSIONAL PRODUCT GUIDE

HMF PROFESSIONAL PRODUCT GUIDE

NEW

Research-driven Proprietary, human-sourced strains

Visit www.seroyal.com/genestrabrands to view the entire GENESTRA BRANDS line Scientifically sound, quality formulas. Genestra Brands supplements supports individualized treatment plans with a 350+ professional-grade product offering in a variety of formats, proven safe, effective and reliable for over 30 years, backed by clinical or traditional evidence.

A trusted Seroyal brand.

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* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Copyright © 2016 Seroyal. All rights reserved. No part of this information may be used or reproduced in any form or by any means, or stored in a database or retrieval system, or be distributed or replicated without express permission of Seroyal. Making copies of any part of this information for any purposes other than your own personal use is a violation of copyright law. 2190. Version 6. Printed 02/2016. TABLE OF CONTENTS Probiotics 101 Probiotics 101 ...... 1 What are probiotics? Who should take Market leader: There are billions of living in the intestinal probiotics? Driving science and innovation tract, often referred to as “microflora”. Probiotics are Daily probiotic supplementation is considered a for over 30 years...... 2 live, “friendly” bacteria in the microflora that work to necessary component of any healthy diet. It supports keep a healthy intestinal balance by replenishing and health in:* maintaining beneficial strains. Maintaining this balance HMF Product Overview • Pre- and post- is critical for overall good health.* DAILY PROBIOTIC • Infants (1 year+), children and adolescents HMF Capsules...... 3 • Adults HMF Forte...... 3 HMF Intensive...... 4 Why supplement • Seniors HMF Intensive Powder...... 4 with probiotics? While probiotics may be added in foods such as HMF Multi ...... 5 Beneficial bacteria may be reduced due to a variety and smoothies, direct probiotic supplementation NEW HMF Multi Strain 50...... 5 of factors: provides the highest amount of beneficial live and active HMF Powder...... 6 cultures. Probiotics should be a routine part of a daily HMF Pre + Probiotic...... 6 • Age • Dietary changes or poor diet lifestyle to help maintain optimal health conditions.* HMF Super Powder...... 7 •  or HMF Replenish Capsules...... 7 other medication use • Stress HMF Replete...... 8 • Lifestyle • Traveling URINARY SUPPORT HMF Cystgen ...... 8 Maintaining bacterial balance in the intestine promotes healthy gastrointestinal function.* EXORPHIN DEGRADING (in vitro) HMF Neuro Capsules...... 9 HMF Neuro Powder...... 9 TOPICAL SUPPORT HMF Candigen Cream ...... 10 PREGNANCY & CHILD SUPPORT HMF Maternity...... 11 HMF Baby B...... 11 HMF Baby F...... 12 HMF Child...... 12 NEW HMF Fit for School...... 13 HMF Natogen...... 13

Probiotic Clinical Trials The Swansea Baby Trial ...... 16 The Sheffield Trial...... 17

See centerfold for the HMF Probiotic Comparison Chart – All ages can benefit from probiotic supplementation.* An easy reference guide to our complete line of daily and condition-specific probiotics

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 1 Market leader Driving probiotic science and innovation for over 30 years

GENESTRA BRANDS Human MicroFlora (HMF) probiotics incorporate safe and effective strains reflecting the latest evidence-based research from human trials, and provide physicians and healthcare professionals a comprehensive range for individualized or condition-specific treatment.* Human-sourced strains Natural pH and bile acid resistance: No enteric coatings required Human-sourced microflora bacterial strains have high survival rates through various stomach pH (1.8- 4.2), thus maximizing intestinal tract exposure and eliminating the need for enteric coatings (capsule/tablet barriers that control digestive absorption). Naturally strong adherence: High ratio of intestinal tract carriage CFU (Colony Forming Unit) levels are important, but effectiveness is best determined through intestinal tract carriage. Human-sourced microflora bacterial strains have a naturally strong adherence to epithelial cells that ensures high ratios of intestinal tract carriage. Research-driven formulations 25 billion CFU/day of: Has been shown to: 10 billion CFU/day of: Has been shown to: • acidophilus (CUL-60) • Promote intestinal comfort* • (CUL-61) • Promote a healthy immune balance* • Lactobacillus acidophilus (CUL-21) • (CUL-08) • Reduce incidence of skin sensitivity • bifidum (CUL-20) • (CUL-20) (Swansea Baby Trial)* • subsp. lactis (CUL-34) • Bifidobacterium animalis subsp. lactis (CUL-34)

Probiotic expertise: Global research and development drive category innovation A collaborative think-tank lead by Dr. Nigel Plummer has produced peer-reviewed and PubMed listed publications. Nigel Plummer, PhD.: Global authority on probiotics A key probiotic contributor, Dr. Plummer has worked at Pfizer in antibiotic R&D and has extensive knowledge in the field. His continued commitment to research has resulted in collaborations with research institutes and universities within the U.K. and Europe, enabling Dr. Plummer to develop his expertise in probiotics, plants supporting microbial balance and fish oils.

Comprehensive range: Convenient formats, age-specific and condition-specific formulas

Products are available in an array of potencies (up to 100 billion CFU), formats (capsules, tablets, powders) and flavors to allow for flexible and convenient dosing. Therapies can be tailored for specific individualized treatments by age (pregnancy support, infants, and children to seniors) or for specific support needs (exorphin-degrading, GI, urinary and topical support).*

2 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. DAILY PROBIOTIC

HMF Capsules HMF Forte PROBIOTIC SUPPLEMENT PROBIOTIC SUPPLEMENT

Supports gastrointestinal health* Promotes intestinal health in adults and children* • Maintains digestive health* • Supports healthy gut microflora balance* • Provides 10 billion CFU per day from two strains of Lactobacillus acidophilus, • Provides 20 billion CFU per day from two strains of Lactobacillus acidophilus, Bifidobacterium bifidum, and Bifidobacterium animalis subsp. lactis Bifidobacterium bifidum, and Bifidobacterium animalis subsp. lactis

HMF Capsules provide four strains of proprietary human-sourced probiotics that support HMF Forte is a unique combination of four strains of proprietary, human-sourced healthy gut flora in adults and children. The microflora composition in the gut is relatively probiotics that helps to promote gastrointestinal health in adults and children. steady, although it can be altered by diet, stress, age and medication use. Probiotics Supplementation with large numbers of a combination of will help support healthy bacterial balance to maintain healthy intestinal function. Probiotics maximize intestinal colonization, supporting the growth of beneficial bacteria. Lactobacilli support the epithelial barrier and mediate the integrity of tight junctions, which control and Bifidobacteria, the most commonly used probiotics, help colonize the intestines and permeability. bacteria Lactobacilli and Bifidobacteria are the most commonly mediate the permeability of epithelial cells. In a randomized, placebo-controlled trial used probiotics, and effectively colonize the intestines. In a randomized, placebo- involving 22 adults, daily supplementation with a probiotic containing Lactobacillus controlled trial involving 22 adults, daily supplementation with a probiotic containing acidophilus supported a healthy microflora balance.* Lactobacillus acidophilus supported healthy microflora balance.* . SUPPLEMENT FACTS . Serving Size 1 Capsule SUPPLEMENT FACTS Servings per Container 60 or 120 Serving Size 2 Capsules Servings per Container 30 Each Capsule Contains Probiotic Consortium 10 billion CFU † Each Capsule Contains % DV Lactobacillus acidophilus (CUL-60) Total Carbohydrate <1 g <1% t Lactobacillus acidophilus (CUL-21) Probiotic Consortium 5 billion CFU † Bifidobacterium bifidum (CUL-20) Lactobacillus acidophilus (CUL-60) Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus acidophilus (CUL-21) Fructooligosaccharides (FOS) 100 mg † Bifidobacterium bifidum (CUL-20) † Daily Value not established Bifidobacterium animalis subsp. lactis (CUL-34) t Percent Daily Values (DV) are based on a 2,000 calorie diet Other Ingredients: Cellulose, hypromellose, silica, stearate † Daily Value not established Recommended Dose Other Ingredients: Cellulose, hypromellose, silica, magnesium stearate Adults and Children (6 years and older): Take one capsule two times daily with meals, Recommended Dose at least two to three hours before or after taking , or as recommended by your healthcare practitioner. Adults and Children (6 years and older): Take two capsules two times daily with meals, or as recommended by your healthcare practitioner. Size Product Code Size Product Code 60 Vegetable Capsules 10418 120 Vegetable Capsules 10418120 60 Vegetable Capsules 10409

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 3 DAILY PROBIOTIC

HMF Intensive HMF Intensive Powder PROBIOTIC SUPPLEMENT PROBIOTIC SUPPLEMENT

Supports intestinal health* Supports intestinal health* • Provides 25 billion CFU per day of two strains of Lactobacillus acidophilus, • Provides 25 billion CFU per day of two strains of Lactobacillus acidophilus, Bifidobacterium bifidum, and Bifidobacterium animalis subsp. lactis Bifidobacterium bifidum, and Bifidobacterium animalis subsp. lactis

HMF Intensive Capsules provide four strains of proprietary human-sourced probiotics that HMF Intensive Powder provides four strains of proprietary human-sourced probiotics that promote intestinal health in children, adolescents, and adults. Although the microflora promote intestinal health in children, adolescents, and adults. Lactobacilli and composition in the gut is relatively steady, it can be altered by diet, stress, age and Bifidobacteria are the most commonly used probiotics. They effectively colonize the medication use. Probiotics reinforce the epithelial barrier and mediate intestinal intestines and promote healthy levels of intestinal bacteria into circulation. Probiotics permeability by controlling the integrity of tight junctions. Lactobacilli and Bifidobacteria reinforce the epithelial barrier and mediate by controlling the are the most commonly used probiotics, effectively colonize the intestines, and promote integrity of tight junctions. Although the microflora composition in the gut is relatively the presence of beneficial bacteria to support normal intestinal function. In a randomized, steady, it can be altered by diet, stress, age and medication use. Probiotics promote the placebo-controlled trial involving 155 adults, daily intake of a probiotic supplement presence of beneficial bacteria to support normal intestinal function. In a randomized, providing 25 billion CFU (containing two strains each of Lactobacillus acidophilus and placebo-controlled trial involving 155 adults, daily intake of a probiotic supplement Bifidobacterium) for 21 days significantly and positively affected the intestinal .* providing 25 billion CFU (containing two strains each of Lactobacillus acidophilus and Bifidobacterium) for 21 days significantly and positively affected the intestinal microbiota.* . SUPPLEMENT FACTS Serving Size 1 Capsule SUPPLEMENT FACTS Servings per Container 60 Serving Size 1 Scoop (1 g) Each Capsule Contains Servings per Container 30 % DV for Adults % DV for Probiotic Consortium 25 billion CFU † and Children Children Lactobacillus acidophilus (CUL-60) Each Serving Contains 4+ Years 3-4 Years Lactobacillus acidophilus (CUL-21) Total Carbohydrate <1 g <1 %♦ † Bifidobacterium bifidum (CUL-20) Probiotic Consortium 25 billion CFU † † Bifidobacterium animalis subsp. lactis (CUL-34) Lactobacillus acidophilus (CUL-60) † Daily Value not established Lactobacillus acidophilus (CUL-21) Bifidobacillus bifidum (CUL-20) Other Ingredients: Cellulose, hypromellose Bifidobacillus animalis subsp. lactis (CUL-34) t Percent Daily Values (DV) are based on a 2,000 calorie diet Recommended Dose † Daily Value (DV) not established Adults and Children (6 years and older): Take one capsule daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare Other Ingredients: Maltodextrin practitioner. Recommended Dose Size Product Code Adults, Adolescents and Children (3 years and older): In a glass, add water or to 30 Vegetable Capsules 10431 one scoop of HMF Intensive Powder and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner.

Size Product Code Net Weight 1 oz (30 g) Powder 10486

4 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. DAILY PROBIOTIC

HMF Multi Strain HMF Multi Strain 50 PROBIOTIC SUPPLEMENT PROBIOTIC SUPPLEMENT

Multistrain probiotic formula promotes gastrointestinal health* 15-strain probiotic combination* • Supports a healthy gut microflora* • Helps to reduce intestinal transit time* • Provides 15 billion CFU per capsule from a combination of 16 strains • Helps support a healthy * • May enhance aspects of cellular immunity* HMF Multi Strain is a combination of 16 probiotic strains that promote a healthy gut • Supports gastrointestinal health* microflora. The intestines are a critical barrier that selectively allow absorption or promote • Supports a favorable gut flora* the excretion of compounds, and their optimal function depends on a healthy bacterial balance. The intestinal microbiota contains more than 400 bacterial , and can be HMF Multi Strain 50 capsules include 50 billion CFU from a combination of 15 probiotic altered by antibiotic use, aging, and premature or caesarean births. Probiotics reinforce the strains. These research-driven strains were selected based on their ability to support both epithelial barrier and control permeability by mediating tight junction integrity, thereby gastrointestinal and immune health. HMF Multi Strain 50’s probiotic consortium contains supporting gastrointestinal health.* proprietary human-sourced strains, and includes 8 strains of Lactobacilli and 6 strains of Bifidobacteria. subsp. boulardii (CNCM-I-1079) live cells . are also provided for additional microflora support. SUPPLEMENT FACTS Serving Size 1 Capsule In a recent placebo-controlled clinical trial, daily supplementation with HN019 for two Servings per Container 30 weeks significantly reduced intestinal transit time; following supplementation, intestinal Each Capsule Contains transit time was decreased by approximately 30%, which was associated with an Probiotic Consortium 15 billion CFU † approximate 35.8% reduction in occasional . BL-04 and NCFM™ support Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) year-round immune health and may enhance certain aspects of cellular immunity, such as Bifidobacterium bifidum (CUL-20) cytokine-dependent cellular signaling. Two recent, placebo-controlled human clinical Bifidobacterium animalis subsp. lactis (CUL-34) trials have found that these strains provide support for seasonal immune health in healthy Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) participants. As well, supplementation with a combination of CUL-60, CUL-21, CUL-31 (CUL-66) and CUL-20 may help to enhance certain aspects of cellular immunity in healthy (CUL-06) individuals.* (CUL-67) Lactobacillus gasseri (CUL-09) Bifidobacterium animalis subsp. lactis (CUL-62) . (CUL-74) SUPPLEMENT FACTS subsp. thermophilus (CUL-68) Serving Size 1 Capsule Lactobacillus acidophilus (NCFM™) Servings per Container 30 Bifidobacterium animalis subsp. lactis (HN019) Each Capsule Contains (HN001) Probiotic Consortium 50 billion CFU † † Daily Value not established Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Other Ingredients: Hypromellose, cellulose, silica Bifidobacterium animalis subsp. lactis (CUL-34) Bifidobacterium bifidum (CUL-20) Recommended Dose Bifidobacterium animalis subsp. lactis (HN019) Adults, Adolescents and Children (6 years and older): Take one capsule daily, at least Bifidobacterium animalis subsp. lactis (BL-04) two to three hours before or after taking antibiotics, or as recommended by your healthcare Lactobacillus salivarius (CUL-61) practitioner. Lactobacillus paracasei (CUL-08) Lactobacillus casei (CUL-06) Size Product Code Lactobacillus gasseri (CUL-09) 60 Vegetable Capsules 10487 Bifidobacterium breve (CUL-74) Lactobacillus plantarum (CUL-66) Lactobacillus acidophilus (NCFM®) Bifidobacterium animalis subsp. lactis (CUL-62) Saccharomyces cerevisiae subsp. boulardii (CNCM-I-1079) † Daily Value not established NCFM® is used with permission under license

Other Ingredients: Cellulose, hypromellose, silica Recommended Dose Take one capsule daily or as recommended by your healthcare practitioner.

Size Product Code 30 Vegetable Capsules 10498

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 5 DAILY PROBIOTIC

HMF Powder HMF Pre + Probiotic PROBIOTIC SUPPLEMENT PROBIOTIC SUPPLEMENT

Fructooligosaccharides and probiotics to promote intestinal health* Low-level maintenance • Provides 22 billion CFU per day from two strains of Lactobacillus acidophilus, • 1.25 billion CFU per dose Bifidobacterium bifidum, and Bifidobacterium animalis subsp. lactis • Includes fructooligosaccharides • Includes 1,760 mg of fructooligosaccharides (FOS) per day Ideal for vegans • Convenient powder format HMF Powder is a synbiotic combination of four strains of proprietary human-sourced probiotics and FOS that promotes optimal intestinal health. The intestinal microbiota, HMF Pre + Probiotic is a low-level, long-term maintenance synbiotic formula which which contains more than 400 bacterial species, can be altered by medication use, aging, provides two strains of proprietary human-sourced Lactobacillus acidophilus, and premature or caesarean births. The intestines are a critical barrier that selectively allow Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, along with absorption or promote the excretion of compounds, and their optimal function depends fructooligosaccharides to specifically assist in maintaining healthy intestinal flora.* on a healthy bacterial balance. The most commonly used probiotics are Lactobacilli and Bifidobacteria. They effectively colonize the intestines, but after their ingestion ends, their . counts decline. Probiotics also reinforce the epithelial barrier and control permeability by SUPPLEMENT FACTS mediating tight junction integrity. Prebiotics, including FOS, are fermented by microbes in Serving Size 1 Scoop (5 g) the , which in turn results in the production of short chain fatty acids, Servings per Container 50 Each Serving Contains % DV including butyrate, the preferred energy source in colon cells. Synbiotic products support Calories 10 the growth of healthy bacteria already living in the colon and supplemented probiotic Total Carbohydrate 5 g 2%t strains.* 5 g 19%t Probiotic Consortium 1.25 billion CFU † Lactobacillus acidophilus (CUL-60) . Lactobacillus acidophilus (CUL-21) SUPPLEMENT FACTS Bifidobacterium bifidum (CUL-20) Serving Size 1 Scoop (1 g) Bifidobacterium animalis subsp. lactis (CUL-34) Servings per Container 60 Fructooligosaccharides (FOS) 2.5 † % DV for Adults % DV for and Children Children Psyllium (Plantago ovata) Husk 2.19 g † Each Serving Contains 4+ Years 3-4 Years t Percent Daily Values (DV) are based on a 2,000 calorie diet Total Carbohydrate <1 g <1 %♦ † † Daily Value (DV) not established Probiotic Consortium 11 billion CFU † † Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Recommended Dose Bifidobacterium bifidum (CUL-20) Adults and Adolescents (12 years and older): In a glass, add water or juice to one Bifidobacterium animalis subsp. lactis (CUL-34) heaped scoop of HMF Pre + Probiotic and mix. Take once daily, at least two to three hours Fructooligosaccharides (FOS) 880 mg before or after taking antibiotics or other medications, or as recommended by your healthcare t Percent Daily Values (DV) are based on a 2,000 calorie diet practitioner. Drink a full glass of liquid with each serving. When used as a gentle , effects † Daily Value (DV) not established are observed twelve to twenty-four hours after first dose, and may take two to three days.

Recommended Dose Size Product Code Net Weight 8.8 oz (250 g) 10423 Adults and Children (1 year and older): In a glass, add water or milk to one scoop 1 ( /4 teaspoon) of HMF Powder and mix. Take two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner.

Size Product Code Net Weight 2 . 1 oz (60 g) 10408

6 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. DAILY PROBIOTIC

HMF Super Powder HMF Replenish Capsules PROBIOTIC SUPPLEMENT PROBIOTIC SUPPLEMENT

Supports intestinal health* Promotes gastrointestinal health* • Provides 20 billion CFU per day from two strains of Lactobacillus acidophilus, • Supports a healthy gut microflora* Bifidobacterium bifidum, and Bifidobacterium animalis subsp. lactis • Promotes healthy digestive function* • Provides 1600 mg of fructooligosaccharides (FOS) per day • Provides 100 billion CFU per dose from two strains of Lactobacillus acidophilus, Bifidobacterium bifidum, Bifidobacterium animalis subsp. lactis, and Lactobacillus HMF Super Powder provides 20 billion CFU per day of proprietary human-sourced salivarius probiotics that promote optimal intestinal health. Lactobacilli and Bifidobacteria are the most commonly used probiotics, and effectively colonize the intestines. Probiotics HMF Replenish Capsules contain five strains of proprietary human-sourced probiotics that reinforce the epithelial barrier and mediate intestinal permeability by controlling the support gastrointestinal health. Lactobacillus and Bifidobacterium promote healthy intestinal integrity of tight junctions. They promote the presence of beneficial bacteria to support microflora and support healthy . In a randomized, placebo-controlled trial involving normal intestinal function. In a randomized, placebo-controlled trial involving 155 adults, 52 adults, daily supplementation with probiotics supported digestive health.* daily intake of a probiotic supplement providing 25 billion CFU (containing two strains each of Lactobacillus acidophilus and Bifidobacterium) for 21 days significantly and positively affected the intestinal microbiota. FOS are non-digestible food ingredients that . SUPPLEMENT FACTS support the growth and activity of Bifidobacteria and Lactobacilli in the human colon.* Serving Size 1 Capsule Servings per Container 14 Each Capsule Contains SUPPLEMENT FACTS Probiotic Consortium 100 billion CFU † Serving Size 1 Scoop (1 g) Lactobacillus acidophilus (CUL-60) Servings per Container 30 Lactobacillus acidophilus (CUL-21) % DV for Adults % DV for Bifidobacterium bifidum (CUL-20) and Children Children Bifidobacterium animalis subsp. lactis (CUL-34) Each Serving Contains 4+ Years 3-4 Years Lactobacillus salivarius (CUL-61) Total Carbohydrate <1 g <1 %♦ † † Daily Value not established Probiotic Consortium 10 billion CFU † † Lactobacillus acidophilus (CUL-60) Other Ingredients: Fructooligosaccharides (FOS), hypromellose, silica, magnesium stearate Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Recommended Dose Bifidobacterium animalis subsp. lactis (CUL-34) Adults and Children (6 years and older): Take one capsule daily with a meal, at least Fructooligosaccharides (FOS) 800 mg † † two to three hours before or after taking antibiotics, or as recommended by your healthcare t Percent Daily Values (DV) are based on a 2,000 calorie diet practitioner. † Daily Value (DV) not established Other Ingredients: Fructose Size Product Code 14 Vegetable Capsules 10457 Recommended Dose Adults and Children (1 year and older): In a glass, add water or milk to one scoop 1 ( /4 teaspoon) of HMF Super Powder and mix. Take two times daily with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner.

Size Product Code Net Weight 4.2 oz (120 g) 10427

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 7 DAILY PROBIOTIC URINARY SUPPORT

HMF Replete HMF Cystgen PROBIOTIC SUPPLEMENT PROBIOTIC SUPPLEMENT

Promotes healthy gut flora* Promotes urinary tract and intestinal health* • Supports gastrointestinal and digestive health* • Provides antioxidant support* • Provides 75 billion CFU per day from two strains of Lactobacillus acidophilus, • Provides 10 billion CFU per day from a combination of two proprietary, Bifidobacterium bifidum, Bifidobacterium animalis subsp. lactis, and Lactobacillus human-sourced strains salivarius • Includes 832 mg of cranberry fruit juice concentrate and 600 mg of C per day

HMF Replete is a unique combination of proprietary human-sourced probiotics that HMF Cystgen provides two strains of Lactobacillus acidophilus formulated to support supports a healthy intestinal microflora. The intestines contain more than 400 bacterial optimal urinary tract health. The microbial species that inhabit the vaginal tract help species, and bacterial balance is necessary for a healthy intestinal tract. Probiotics, maintain urogenital health. Despite the close proximity of the vagina to the anus, the including Lactobacillus and Bifidobacterium, promote healthy microflora, support normal diversity of microbes present in the vagina is much lower than in the gut. Research intestinal microbiota, and promote digestive health. In a randomized, placebo-controlled suggests that the intestinal and urogenital microbial flora have a central role in trial involving 52 adults, daily probiotic supplementation supported gastrointestinal maintaining health and well-being. The probiotic organisms present in HMF Cystgen help health.* maintain healthy microflora. and cranberry fruit extract provide antioxidants to further promote urinary tract health.* . SUPPLEMENT FACTS . Serving Size ½ Sachet (10 g) SUPPLEMENT FACTS Servings per Container 14 Serving Size ¼ Sachet (1.9 g) Each Serving Contains % DV Servings per Container 24 Calories 25 Each Serving Contains % DV Total Carbohydrate 9 g 3% t Vitamin C (ascorbic acid) 150 mg 250% Dietary Fiber 5 g 20% t (potassium citrate/ bicarbonate) 379 mg 11% Sugars 4 g † Probiotic Consortium 2.5 billion CFU † Probiotic Consortium 75 billion CFU † Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Lactobacillus acidophilus (CUL-21) Cranberry (Vaccinium macrocarpon) Bifidobacterium bifidum (CUL-20) Fruit Juice Concentrate (36:1) 208 mg † Bifidobacterium animalis subsp. lactis (CUL-34) 7.5 g Fresh Equivalent Lactobacillus salivarius (CUL-61) † Daily Value not established Fructooligosaccharides (FOS) 5 g t Percent Daily Values (DV) are based on a 2,000 calorie diet Other Ingredients: Cellulose, citric acid † Daily Value (DV) not established

Other Ingredients: Apricot powder Recommended Dose Adults: Take ¼ sachet four times daily or as recommended by your healthcare practitioner. Take Recommended Dose with food or immediately after meals. Completely dissolve powder in ¼ glass of cold water or Adults: In a glass, add water to ½ sachet of HMF Replete and mix. Take once daily with a juice. Allow fizzing to stop before drinking. Take at least two to three hours before or after taking meal, at least two to three hours before or after taking antibiotics or as recommended by your antibiotics. healthcare practitioner. Size Product Code Size Product Code 6 - 0.3 oz (7.5 g) [Net Weight 1.6 oz (45 g)] 10413 7- 0.7 oz (20 g) Sachets of Powder] 10419 [Net Weight 4.9 oz (140 g)

8 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. EXORPHIN-DEGRADING (in vitro)

HMF Neuro Capsules HMF Neuro Powder PROBIOTIC SUPPLEMENT PROBIOTIC SUPPLEMENT

Probiotics to support gastrointestinal health in adults and children* Supports gastrointestinal health in adults* • Contains L. rhamnosus, a probiotic that has shown exorphin-degrading activity in vitro* • Contains L. rhamnosus, a probiotic that has shown exorphin-degrading activity in vitro* • Provides 24 billion CFU per daily dose • Provides 24 billion CFU per daily dose • Includes 500 mg of L- per daily dose • Includes 1000 mg of L-glutamine and 500 mg of fructooligosaccharides (FOS) per daily dose HMF Neuro Capsules contain a combination of five proprietary, human-sourced probiotics • Great-tasting apricot flavor and the amino acid L-glutamine. Included in this probiotic blend is L. rhamnosus, a strain that has demonstrated exorphin-degrading activity in vitro. Exorphins are peptides HMF Neuro Powder provides a combination of five proprietary, human-sourced probiotics, produced during the digestion of certain foods, including and dairy products. plus the amino acid L-glutamine and FOS in a delicious apricot-flavored powder. This L. rhamnosus has been shown to eliminate exorphins from wheat and milk in intestinally- probiotic blend includes L. rhamnosus, a strain that has demonstrated exorphin-degrading stimulated conditions. This strain has been combined with four proprietary, research- activity in vitro. Exorphins are peptides produced during the digestion of certain foods, driven strains to support gastrointestinal health and contribute to a favourable gut flora.* including wheat and dairy products. In intestinally-stimulated conditions, L. rhamnosus has been shown to extensively eliminate exorphins from wheat and milk. This probiotic . helps to support gastrointestinal health and contribute to a favorable gut flora along with SUPPLEMENT FACTS four other proprietary, research-driven strains.* Serving Size 1 Capsule Servings per Container 60 Each Capsule Contains . Probiotic Consortium 12 billion CFU † SUPPLEMENT FACTS Serving Size 1 Scoop (1 g) Lactobacillus acidophilus (CUL-60) Servings per Container 60 Lactobacillus acidophilus (CUL-21) Bifidobacterium bifidum (CUL-20) Each Serving Contains Bifidobacterium animalis subsp. lactis (CUL-34) Probiotic Consortium 12 billion CFU † Lactobacillus rhamnosus (CUL-63) Lactobacillus acidophilus (CUL-60) L-Glutamine 250 mg † Lactobacillus acidophilus (CUL-21) † Daily Value not established Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Other Ingredients: Hypromellose, silica, magnesium stearate Lactobacillus rhamnosus (CUL-63) L-Glutamine 500 mg † Recommended Dose Fructooligosaccharides (FOS) 250 mg † Adults, Adolescents and Children (6 years and older): Take one capsule two times daily † Daily Value not established with meals, at least two to three hours before or after taking antibiotics, or as recommended by Other Ingredients: Apricot powder your healthcare practitioner. Recommended Dose Size Product Code Adults: In a glass, add water to one scoop of HMF Neuro Powder and mix. Take two times daily 60 Vegetable Capsules 10442 with meals, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner.

Size Product Code Net Weight 2.1 oz (60 g) Powder 10443

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 9 TOPICAL SUPPORT

HMF Candigen Cream PROBIOTIC CREAM

Probiotic cream • Easy application for increased compliance Human-sourced strains • Proprietary, non-pathogenic strains HMF Candigen Cream provides two strains of Lactobacillus. The recommended dosage is a thin layer of cream applied to the external vaginal area two to three times daily. One gram (1 g) of cream contains 80 million CFU of Lactobacillus acidophilus and 20 million CFU of Lactobacillus gasseri, in combination with 2.47 mg of garlic (Allium sativum) clove powder.

. INGREDIENTS: PEG-8, PEG-32, Lactobacillus Ferments [Lactobacillus acidophilus (CUL-60); Lactobacillus gasseri (CUL-09)], Allium Sativum (Garlic) Bulb Extract, Rosa Damascena Flower Oil

Recommended Dose Apply liberally to skin two to three times daily or as recommended by your healthcare practitioner. For external use only.

Size Product Code Net Weight 1.8 oz (50 g) 10566

10 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Support Upper Respiratory Tract Health with HMF Fit For School*

NEW

GENESTRA BRANDS HMF Fit For School supports children’s upper respiratory tract health and immune function using a unique combination of research-driven probiotic strains and vitamin C. Each delicious blackcurrant flavored chewable EGETARIAN tablet provides 12.5 billion CFU of proprietary strains, plus 50 mg of vitamin C – the same formulation shown to help maintain schoolchildren’s immune health in a recent clinical trial. HMF Fit For School also includes additional immune support with 1000 IU of per tablet.*

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Condition-specific support Comprehensive range in convenient formats For individualized treatment, HMF probiotics are available in an array of potencies and formulas to allow for flexibility and efficacy. Human MicroFlora (HMF) Probiotics Comparison Chart CFU PER PRIMARY DOSAGE ADDITIONAL PRODUCT INDICATIONS* UNIT STRAINS FEATURES FOS RECOMMENDED DOSE DAILY PROBIOTIC HMF Low-potency probiotic and 1.25 billion L. acidophilus (CUL-60) Psyllium husk Yes Adults and Children (6 years and older): In a glass, add water Pre + Probiotic formula to gently promote a natural L. acidophilus (CUL-21) or juice to one heaped scoop of HMF Pre + Probiotic and mix. (powder) healthy gut flora balance in a B. bifidum (CUL-20) Take once daily, at least two to three hours before or after taking convenient powder* B. animalis subsp. lactis (CUL-34) antibiotics or other medications, or as recommended by your healthcare practitioner. Drink a full glass of liquid with each serving. When used as a gentle laxative, effects are observed twelve to twenty-four hours after first dose, and may take two to three days. HMF Capsules Lower-potency, encapsulated 5 billion L. acidophilus (CUL-60) No Adults and Children (6 years and older): Take two capsules probiotic blend for general L. acidophilus (CUL-21) two times daily with meals or as recommended by your digestive support* B. bifidum (CUL-20) healthcare practitioner. B. animalis subsp. lactis (CUL-34) HMF Forte Moderate-potency probiotic and 10 billion L. acidophilus (CUL-60) Yes Adults and Children (6 years and older): (capsules) prebiotic formula for enhanced L. acidophilus (CUL-21) Take one capsule two times daily with meals, at least microflora support and G.I. B. bifidum (CUL-20) two to three hours before or after taking antibiotics, or as function* B. animalis subsp. lactis (CUL-34) recommended by your healthcare practitioner. HMF Moderate-potency probiotic and 10 billion L. acidophilus (CUL-60) Yes Adults and Children (1 year and older): In a glass, add water Super Powder prebiotic formula for enhanced L. acidophilus (CUL-21) or milk to one scoop (¼ teaspoon) of HMF Super Powder and microflora support and G.I. B. bifidum (CUL-20) mix. Take two times daily with meals, at least two to three hours function*; convenient powder in a B. animalis subsp. lactis (CUL-34) before or after taking antibiotics, or as recommended by your larger size format healthcare practitioner. HMF Powder Moderate-potency probiotic and 11 billion L. acidophilus (CUL-60) Yes Adults and Children (1 year and older): In a glass, add water prebiotic formula for enhanced L. acidophilus (CUL-21) or milk to one scoop (¼ teaspoon) of HMF Powder and mix. Take microflora support and G.I. B. bifidum (CUL-20) two times daily with meals, at least two to three hours before or function; convenient powder* B. animalis subsp. lactis (CUL-34) after taking antibiotics, or as recommended by your healthcare practitioner. HMF Multi Strain Moderate- potency probiotic 15 billion L. acidophilus (CUL-60) No Adults, Adolescents and Children (6 years and older): Take one (capsules) formula featuring 16 different L. acidophilus (CUL-21) capsule daily, at least two to three hours before or after taking strains for universal G.I. support* B. bifidum (CUL-20) antibiotics, or as recommended by your healthcare practitioner. B. animalis subsp. lactis (CUL-34) L. salivarius (CUL-61) L. paracasei (CUL-08) L. plantarum (CUL-66) L. casei (CUL-06) L. fermentum (CUL-67) L. gasseri (CUL-09) B. animalis subsp. lactis (CUL-62) B. breve (CUL-74) S. salivarius subsp. thermophilus (CUL-68) L. acidophilus (NCFM™) B. animalis subsp. lactis (HN019) L. rhamnosus (HN001) HMF Intensive High-potency probiotic formula for 25 billion L. acidophilus (CUL-60) No Adults and Children (6 years and older): Take one capsule (capsules) microflora balance and G.I. health L. acidophilus (CUL-21) daily with a meal, at least two to three hours before or after support* B. bifidum (CUL-20) taking antibiotics, or as recommended by your healthcare B. animalis subsp. lactis (CUL-34) practitioner. HMF Intensive Powder High-potency probiotic formula 25 billion L. acidophilus (CUL-60) No Adults, Adolescents and Children (3 years and older): In a for microflora balance and G.I. L. acidophilus (CUL- 21) glass, add water or milk to one scoop of HMF Intensive Powder health support; convenient B. bifidum (CUL-20) and mix. Take once daily with a meal, at least two to three powder* B. animalis subsp. lactis (CUL-34) hours before or after taking antibiotics, or as recommended by your healthcare practitioner.

NEW HMF Multi Strain 50 Maximal delivery of 15 different 50 billion L. acidophilus (CUL-60) No Adults, Adolescents and Children (6 years and older): Take one (capsules) probiotics for far-reaching G.I. L. acidophilus (CUL-21) capsule daily or as recommended by your healthcare practitioner. support* B. animalis subsp. lactis (CUL-34) B. bifidum (CUL-20) B. animalis subsp. lactis (HN019) B. animalis subsp. lactis (BL-04) L. salivarius (CUL-61) L. paracasei (CUL-08) L. casei (CUL-06) L. gasseri (CUL-09) B. breve (CUL-74) L. plantarum (CUL-66) L. acidophilus (NCFM®) B. animalis subsp. lactis (CUL-62) S. cerevisiae subsp. boulardii (CNCM-I-1079) CFU PER PRIMARY DOSAGE ADDITIONAL PRODUCT INDICATIONS* UNIT STRAINS FEATURES FOS RECOMMENDED DOSE DAILY PROBIOTIC HMF Replete Highest potency probiotic powder 75 billion L. acidophilus (CUL-60) Yes Adults: In a glass, add water to ½ sachet of HMF Replete and (powder) for broad-spectrum support L. acidophilus (CUL-21) mix. Take once daily with a meal, at least two to three hours B. bifidum (CUL-20) before or after taking antibiotics, or as recommended by your B. animalis subsp. lactis (CUL-34) healthcare practitioner. L. salivarius (CUL-61) HMF Replenish Capsules Highest potency probiotic capsule 100 billion L. acidophilus (CUL-60) Yes Adults and Children (6 years and older): Take one capsule for broad-spectrum support L. acidophilus (CUL-21) daily with a meal, at least two to three hours before or after B. bifidum (CUL-20) taking antibiotics, or as recommended by your healthcare B. animalis subsp. lactis (CUL-34) practitioner. L. salivarius (CUL-61) URINARY SUPPORT HMF Cystgen Helps support urinary tract health* 10 billion L. acidophilus (CUL-60) Vitamin C, No Adults: Take ¼ sachet four times daily or as recommended by (powder) L. acidophilus (CUL-21) potassium, your healthcare practitioner. Take with food or immediately after cranberry meals. Completely dissolve powder in ¼ glass of cold water or fruit juice juice. Allow fizzing to stop before drinking. Take at least two to concentrate three hours before or after taking antibiotics. EXORPHIN DEGRADING (in vitro) HMF Exorphin degrading capacity in 12 billion L. acidophilus (CUL-60) L-Glutamine No Adults: Take one capsule two times daily with meals, at least Neuro Capsules intestinally-simulated conditions* L. acidophilus (CUL-21) two to three hours before or after taking antibiotics, or as B. bifidum (CUL-20) recommended by your healthcare practitioner. B. animalis subsp. lactis (CUL-34) L. rhamnosus (CUL-63) HMF Exorphin degrading capacity in 12 billion L. acidophilus (CUL-60) L-Glutamine Yes Adults: In a glass, add water to one scoop of HMF Neuro Powder Neuro Powder intestinally-simulated conditions* L. acidophilus (CUL-21) and mix. Take two times daily with meals, at least two to three B. bifidum (CUL-20) hours before or after taking antibiotics, or as recommended by B. animalis subsp. lactis (CUL-34) your healthcare practitioner. L. rhamnosus (CUL-63) TOPICAL SUPPORT HMF Supports healthy microflora* 100 million L. acidophilus (CUL-60) Garlic powder No Application: Apply liberally to skin two to three times daily or Candigen Cream L. gasseri (CUL-09) as recommended by your healthcare practitioner. For external use only. PREGNANCY & CHILD SUPPORT HMF Natogen Lower-potency probiotic 3 billion L. acidophilus (CUL-60) No Children (1-4 years): In a glass add water or milk to one scoop (powder) specifically formulated to support L. acidophilus (CUL-21) of HMF Natogen and mix. Take once daily with a meal, at least G.I. health in children* L. paracasei (CUL-08) two to three hours before or after taking antibiotics, or as B. animalis subsp. lactis (CUL-62) recommended by your healthcare practitioner. HMF Baby B Probiotic specifically formulated for 10 billion B. bifidum (CUL-20) Galacto- No Children (1-4 years): In a glass, add water or milk to one scoop of (powder) breast-fed babies* B. animalis subsp. lactis (CUL-34) oligosaccharides HMF Baby B and mix. Take once daily with a meal, at least two to L. salivarius (CUL-61 ) (GOS) three hours before or after taking antibiotics, or as recommended L. paracasei (CUL-08) by your healthcare practitioner. HMF Baby F Probiotic specifically formulated for 10 billion B. bifidum (CUL-20) Galacto- Yes Children (1-4 years): In a glass, add water or milk to one scoop of (powder) formula-fed babies* B. animalis subsp. lactis (CUL-34) oligosaccharides HMF Baby F and mix. Take once daily with a meal, at least two to L. salivarius (CUL-61 ) (GOS) three hours before or after taking antibiotics, or as recommended L. paracasei (CUL-08) by your healthcare practitioner. HMF Maternity Probiotic specifically formulated to 10 billion B. bifidum (CUL-20) No Women: Take one capsule daily with a meal, at least two (capsules) support pregnant women* B. animalis subsp. lactis (CUL-34) to three hours before or after taking antibiotics, or as L. salivarius (CUL-61) recommended by your healthcare practitioner. L. paracasei (CUL-08) HMF Child Child-specific chewable probiotic 12.5 billion L. acidophilus (CUL-60) No Children (4 years and older): Chew one tablet two times (chewable tablets) to support G.I. health* L. acidophilus (CUL-21) and daily with meals, at least two to three hours before or after B. bifidum (CUL-20) blend taking antibiotics, or as recommended by your healthcare B. animalis subsp. lactis (CUL-34) practitioner. L. salivarius (CUL-61 ) L. paracasei (CUL-08)

NEW HMF Fit For School Chewable probiotic to support 12.5 billion L. acidophilus (CUL-60) Added No Adolescents and Children (4 years and older): Chew (chewable tablets) G.I. health and immune function* L. acidophilus (CUL-21) vitamin C and one tablet daily or as recommended by your healthcare B. bifidum (CUL-20) vitamin D practitioner. B. animalis subsp. lactis (CUL-34)

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. US: (888) 737-6925 | www.seroyal.com Support for daily digestive health*

NEW

HMF Multi Strain 50 provides complete support for daily digestive health, with 50 billion CFU from a combination of 15 thoroughly-researched probiotics.

A healthy is a key factor in both digestive and immune function, as it acts as the first line of defense for the immune system.HMF Multi Strain 50 includes Bifidobacterium animalis subsp. lactis (HN019) which has been clinically evaluated for the reduction of intestinal transit time, as well as BL-04 and NCFM® strains, which have been clinically tested for their immune health benefits. Saccharomyces cerevisiae subsp. boulardii live yeast cells are also included to help maintain optimal gut flora composition.*

HMF Multi Strain 50 is ideal for vegans and free of added gluten.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. PREGNANCY & CHILD SUPPORT

HMF Maternity HMF Baby B PROBIOTIC SUPPLEMENT PROBIOTIC SUPPLEMENT FOR BREAST-FED BABIES Intestinal support with proprietary strains • Utilizes human sourced, non-pathogenic proprietary strains that provide strong Probiotic for infants epithelial adherence and a naturally high tolerance to stomach acid • Helps to promote skin health* • Temporarily modify gut flora* • Helps to reduce incidence of skin sensitivity* Supports pregnant women • Unique consortium of proprietary strains HMF Baby B probiotic formula for breast-fed babies provides Lactobacillus salivarius, Lactobacillus paracasei, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, Healthy intestinal bacteria are just as important to infants as to adults. Microflora which help to promote immune function and skin health in children. HMF Baby B powder composition remains relatively unchanged after infancy. Thus, the acquisition of a dissolves easily into milk or water, and is free of gluten and soy. Ideal for vegetarian beneficial flora potential in the newborn can be significantly enhanced if the mother also children.* takes a probiotic during pregnancy. Additionally, probiotics will help support the intestinal function of the mother during the pregnancy period.* . SUPPLEMENT FACTS Serving Size 1 Scoop (200 mg) . Servings per Container 30 SUPPLEMENT FACTS Each Serving Contains Serving Size 1 Capsule Servings per Container 30 Probiotic Consortium 10 billion CFU † Bifidobacterium bifidum (CUL-20) Each Capsule Contains Bifidobacterium animalis subsp. lactis (CUL-34) Probiotic Consortium 10 billion CFU † Lactobacillus salivarius (CUL-61) Bifidobacterium bifidum (CUL-20) Lactobacillus paracasei (CUL-08) Bifidobacterium animalis subsp. lactis (CUL-34) † Daily Value not established Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Other Ingredients: Transgalactooligosaccharides (GOS) (from milk) † Daily Value not established Contains: Milk Other Ingredients: Maltodextrin, hypromellose Recommended Dose Children (1-4 years): In a glass, add water or milk to one scoop of HMF Baby B and mix. Recommended Dose Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as Women: Take one capsule daily with a meal, at least two to three hours before or after taking recommended by your healthcare practitioner. antibiotics, or as recommended by your healthcare practitioner. Size Product Code Size Product Code Net Weight 0.2 oz (6 g) Powder 10491 30 Vegetable Capsules 10492

EGETARIAN

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 11 PREGNANCY & CHILD SUPPORT

HMF Baby F HMF Child PROBIOTIC SUPPLEMENT PROBIOTIC SUPPLEMENT FOR FORMULA-FED BABIES Supports digestive health in children* Probiotic for infants • Supports skin health and immune function* • Helps to promote skin health* • Provides 25 billion CFU per day from two strains of Lactobacillus acidophilus, • Helps to reduce incidence of skin sensitivity* Bifidobacterium bifidum, Lactobacillus paracasei, Lactobacillus salivarius, and Bifidobacterium animalis subsp. lactis per dose HMF Baby F probiotic formula for formula-fed babies provides Lactobacillus salivarius, • Delicious blackcurrant flavor Lactobacillus paracasei, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, which help to promote immune function and skin health in children. HMF Baby F HMF Child probiotic formula is a great-tasting and unique combination of probiotics, contains galactooligosaccharides (GOS), a type of prebiotic fiber found naturally with including Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus paracasei, that may help to support a healthy gastrointestinal microflora in infants. Lactobacillus salivarius, and Bifidobacterium animalis subsp. lactis, which help maintain a Fructooligosaccharides (FOS) are also included for additional prebiotic fiber content. child’s healthy gut flora. Bifidobacterium bifidum and Lactobacillus lactis are found in the HMF Baby F powder dissolves easily into milk or water, and is free of gluten and soy. intestinal flora of healthy children. Probiotics influence the intestinal microbiota, modulate Ideal for vegetarian children.* the immune response, and support skin health. Double-blind, placebo-controlled clinical studies indicate that HMF Probiotics, at a core consortium of 25 billion CFU, support . gastrointestinal health and digestive function.* SUPPLEMENT FACTS Serving Size 1 Scoop (1.1 g) Servings per Container 60 . SUPPLEMENT FACTS Each Serving Contains Serving Size 1 Tablet Total Carbohydrate 1 g † Servings per Container 30 Probiotic Consortium 10 billion CFU † Each Tablet Contains % DV Bifidobacterium bifidum (CUL-20) Total Carbohydrate <1 g <1%  Bifidobacterium animalis subsp. lactis (CUL-34) Probiotic Consortium 12.5 billion CFU † Lactobacillus salivarius (CUL-61) Lactobacillus acidophilus (CUL-60) Lactobacillus paracasei (CUL-08) Lactobacillus acidophilus (CUL-21) † Daily Value not established Bifidobacterium bifidum (CUL-20) Bifidobacterium animalis subsp. lactis (CUL-34) Other Ingredients: Transgalactooligosaccharides (GOS) (from milk), fructooligosaccharides (FOS) Lactobacillus salivarius (CUL-61) Contains: Milk Lactobacillus paracasei (CUL-08) t Percent Daily Values (DV) are based on a 2,000 calorie diet Recommended Dose † Daily Value not established Children (1-4 years): In a glass, add water or milk to one scoop of HMF Baby F and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as Other Ingredients: Sorbitol, xylitol, natural blackcurrant flavor, silica, magnesium stearate recommended by your healthcare practitioner. Recommended Dose Size Product Code Children (4 years and older): Chew one tablet two times daily with meals, or as Net Weight 2.3 oz (66 g) Powder 10493 recommended by your healthcare practitioner. Size Product Code EGETARIAN 30 Chewable Tablets 10451

12 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. PREGNANCY & CHILD SUPPORT

HMF Fit For School HMF Natogen PROBIOTIC SUPPLEMENT PROBIOTIC SUPPLEMENT

Children’s immune support formula* Supports healthy gut flora in young children* • Helps to support upper respiratory tract health in children* • Supports gastrointestinal health* • Provides 12.5 billion CFU of live microorganisms that temporarily modify gut flora* • Includes 3 billion CFU per day from two strains of Lactobacillus acidophilus, Lactobacillus • Includes 50 mg of vitamin C and 1000 IU of vitamin D per serving paracasei, and Bifidobacterium animalis subsp. lactis • Chewable tablets with a delicious natural blackcurrant flavor HMF Natogen is a unique combination of four strains of proprietary human-sourced HMF Fit For School includes a combination of research-driven probiotic strains and vitamin probiotics that promotes intestinal health in young children. Lactobacilli and C that supports children’s upper respiratory tract health and immune function.* In a recent Bifidobacteria are the most commonly used probiotics, and they effectively colonize the clinical trial, 57 schoolchildren were randomized to receive either a placebo tablet or HMF intestines. The human intestinal tract contains more than 400 bacterial species, and a Fit For School’s probiotic formula plus 50 mg of vitamin C daily for 6 months. Children in healthy bacterial balance is necessary for a healthy gastrointestinal tract. Probiotics the probiotic plus vitamin C group had significant improvement in upper respiratory tract promote the presence of beneficial bacteria, and strengthen the epithelial barrier. health.* HMF Fit For School also includes 25 mcg (1000 IU) of vitamin D per tablet to Probiotics transiently impact the ’s microflora, as once their ingestion ends, they provide additional immune support.* decline in numbers. As the microflora composition in children is relatively unchanged after infancy, it significantly depends on the diet.* . SUPPLEMENT FACTS . Serving Size 1 Tablet SUPPLEMENT FACTS Servings per Container 30 Serving Size 1 Scoop (100 mg) Each Tablet Contains % DV Servings per Container 60 Vitamin C (ascorbic acid) 50 mg 83% Each Capsule Contains Vitamin D (cholecalciferol) 1000 IU 250% 3 Probiotic Consortium 3 billion CFU † Probiotic Consortium 12.5 billion CFU † Lactobacillus acidophilus (CUL-60) Lactobacillus acidophilus (CUL-21) Lactobacillus acidophilus (CUL-21) Lactobacillus acidophilus (CUL-60) Lactobacillus paracasei (CUL-08) Bifidobacterium animalis subsp. lactis (CUL-34) Bifidobacterium animalis subsp. lactis (CUL-62) Bifidobacterium bifidum (CUL-20) † Daily Value not established † Daily Value (DV) not established Other Ingredients: monohydrate (milk) Other Ingredients: Xylitol, blackcurrant fruit extract, sorbitol, natural blackcurrant flavor, silica, magnesium stearate Recommended Dose Children (1-4 years): In a glass add water or milk to one scoop of HMF Natogen and mix. Recommended Dose Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as Adolescents and Children (4 years and older): Chew one tablet daily or as recommended recommended by your healthcare practitioner. by your healthcare practitioner. Size Product Code Size Product Code Net Weight 0.2 oz (6 g) Powder 10424 30 Chewable Tablets 10497

EGETARIAN

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 13 Get an Early Start on Skin and Digestive Health*

EGETARIAN

The HMF Baby product family supports optimal microflora composition and gastrointestinal health using a combination of research-driven probiotic strains.*

HMF Baby B (for breast-fed babies) and HMF Baby F (for formula- HMF Baby B includes additional microflora support from fed babies) each provide 10 billion CFU of proprietary human- added galactooligosaccharides (GOS), a prebiotic fiber similar sourced strains. Research indicates that probiotic supplementation to oligosaccharides naturally within breast milk.* HMF Baby F from birth to six months helps support infant immune contains GOS and fructooligosaccharides (FOS). development, which is an important factor for skin health.*

14 * These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Probiotic Clinical Trials Safe and effective strains that reflect the latest evidence-based research from human trials

Genestra Brands probiotic strains have been proven over 30 years to be effective in promoting intestinal balance.* This section provides a detailed overview of the latest trials conducted on human-derived probiotic strains, specifically the results from research that studied probiotics and their effects on skin sensitivity in infants and on occassional intestinal discomfort in adults.*

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 15 The Swansea Baby Trial Probiotics in the Prevention of Skin Sensitivity: A Randomised Controlled Trial (Allen et al., 2014)

Probiotic supplementation was found to safely and until 6 months of age. Skin sensitivity was evaluated at effectively reduce incidence of skin sensitivity. In a 6 months and 2 years of age. In comparison with the infant randomized, double-blind, placebo-controlled, parallel group participants in the placebo group, participants in the probiotic trial, 454 pregnant women at 36 weeks of gestation were group experienced a statistically significant 57% decrease in assigned to either the probiotic capsule treatment group skin sensitivity.* (10 billion CFU from Lactobacillus salivarius CUL61, Lactobacillus paracasei CUL08, Bifidobacterium animalis subsp. lactis CUL34 • 57% decrease in skin sensitivity* and Bifidobacterium bifidum CUL20) or the placebo capsule group. Participants began daily supplementation until giving birth; participants’ infants then began daily supplementation

Skin Sensitivity at 2 Years Percent Placebo Group 12.10% Probiotic Group 5.30%

Reduced Skin Sensitivity at 2 Years in Probiotic Group*

14.00%

12.00%

10.00% * 8.00%

6.00%

4.00%

2.00%

0.00% * p < 0.05 Placebo Group Probiotic Group

16 * These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The Sheffield Trial Clinical Trial: a Multistrain Probiotic Preparation Significantly Reduces Intestinal Discomfort in a Double-Blind Placebo-Controlled Study (Williams et al., 2008)

Probiotic supplementation was found to decrease bloating, satisfaction with bowel habits, and quality of life) at the number of days with intestinal discomfort, while baseline and every 2 weeks during supplementation. In the improving satisfaction with bowel habits and overall probiotic group, satisfaction with bowel habits was significantly quality of life. This 8-week long, double-blind, randomized, improved in just 6 weeks, and quality of life scores were placebo-controlled study was conducted in 52 participants. improved after 8 weeks of supplementation. Participants were randomized to either the placebo capsule group or the probiotic capsule group (25 billion CFU from • 22% decrease in days with intestinal discomfort Lactobacillus acidophilus CUL60 and CUL 21, Bifidobacterium animalis subsp. lactis CUL34, and Bifidobacterium bifidum • 32% improvement in satisfaction with bowel habits CUL20). Participants scored their intestinal discomfort (including

Intestinal Discomfort Scores Probiotic Group Placebo Group Before Supplementation 282.68 252.08 At 8 Weeks of Probiotic Supplementation 150.23 172 % Change at Week 8 133.39 80.66

Probiotic Supplementation Reduces Intestinal Discomfort Severity Scores*

300

250

200 *

150

100 Before Supplementation At 8 Weeks of Probiotic Supplementation * p < 0.05

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 17 Bloating Symptom Severity Scores Probiotic Group Placebo Group Before Supplementation 48.54 46.71 2 Weeks After End of Probiotic 36.65 39.27 Supplementation % Change at Week 10 12.04 7.52

Probiotic Supplementation Reduces Bloating Symptom Severity Scores*

50 48

46 44 42 * 40 38 36 34 32

30 Before Supplementation 2 Weeks After End of Probiotic Supplementation * p < 0.05

Satisfaction With Bowel Habits Probiotic Group Before Supplementation 73.39 At 8 Weeks of Probiotic Supplementation 39.65

Probiotic Supplementation Improves Satisfaction With Bowel Habits

80

70

60

50 *

40

30

20 Before Supplementation At 8 Weeks of Probiotic Supplementation * p < 0.05

18 * These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Days with Intestinal Discomfort Before Supplementation 2 Weeks After End of Probiotic Supplementation Placebo Group 42.67 32.14 Probiotic Group 48.64 28.27 % Change at Week 10 12.04 7.52

Fewer Days With Intestinal Discomfort in Probiotic Group

*

50

45

40 Placebo Group Probiotic Group 35 * 30

25

20 Before Supplementation 2 Weeks After End of Probiotic Supplementation * p < 0.05

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 19 Notes

A trusted Seroyal brand.

To order, call: 1-888-737-6925 [email protected] For more information, visit: www.seroyal.com

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