The Parasympathetic System
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
METHODICAL GUIDANCE for the Lecture Academic Subject Human
Ministry of Public Health of Ukraine Ukrainian Medical Stomatological Academy "Approved" at the meeting of the Department of Human Anatomy «29» 08 2020 Minutes № Head of the Department Professor O.O. Sherstjuk ________________________ METHODICAL GUIDANCE for the lecture Academic subject Human Anatomy Module No 3 "The heart. Vessels and nerves of the head, the neck, the trunk, extremities" Lecture No 15 Review of the autonomic nervous system, its central departments. The principles of the autonomic innervation of the organs Year of study ІI Faculty Foreign students' training faculty, specialty «Medicine» Number of 2 academic hours Poltava – 2020 1. Educational basis of the topic The autonomic division of peripheral nervous system regulates physiological processes of the human organism like blood circulation, respiration, digestion, excretion and general metabolism; also, it regulates tissue trophic processes. The autonomic division acts relatively independently from the cerebral cortex and the organs supplied act involuntarily as well. It is quite clear that that distinguishing of the somatic and the autonomic compartments is conditional and exact delimitation is not possible. Such impossibility appears due to common regulatory centers for both divisions and tight morphological and functional associations featured by them. The somatic neurons and the interneurons of PNS like those of CNS feature topographical and synaptic associations so a reflex arc may comprise both somatic (e.g. afferent) and autonomic neurons. Summarizing the aforesaid, the term ’autonomic nervous system’ will be applied to a specific compartment of PNS but not for a separate nervous system. 2. Learning objectives of the lecture: . to familiarize students with the autonomic division of CNS; . -
The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’S Disease
life Review The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’s Disease Gianfranco Natale 1,2,* , Larisa Ryskalin 1 , Gabriele Morucci 1 , Gloria Lazzeri 1, Alessandro Frati 3,4 and Francesco Fornai 1,4 1 Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy; [email protected] (L.R.); [email protected] (G.M.); [email protected] (G.L.); [email protected] (F.F.) 2 Museum of Human Anatomy “Filippo Civinini”, University of Pisa, 56126 Pisa, Italy 3 Neurosurgery Division, Human Neurosciences Department, Sapienza University of Rome, 00135 Rome, Italy; [email protected] 4 Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.) Neuromed, 86077 Pozzilli, Italy * Correspondence: [email protected] Abstract: The gastrointestinal (GI) tract is provided with a peculiar nervous network, known as the enteric nervous system (ENS), which is dedicated to the fine control of digestive functions. This forms a complex network, which includes several types of neurons, as well as glial cells. Despite extensive studies, a comprehensive classification of these neurons is still lacking. The complexity of ENS is magnified by a multiple control of the central nervous system, and bidirectional communication between various central nervous areas and the gut occurs. This lends substance to the complexity of the microbiota–gut–brain axis, which represents the network governing homeostasis through nervous, endocrine, immune, and metabolic pathways. The present manuscript is dedicated to Citation: Natale, G.; Ryskalin, L.; identifying various neuronal cytotypes belonging to ENS in baseline conditions. -
Anatomical Planes in Rectal Cancer Surgery
DOI: 10.4274/tjcd.galenos.2019.2019-10-2 Turk J Colorectal Dis 2019;29:165-170 REVIEW Anatomical Planes in Rectal Cancer Surgery Rektum Kanser Cerrahisinde Anatomik Planlar Halil İbrahim Açar, Mehmet Ayhan Kuzu Ankara University Faculty of Medicine, Department of General Surgery, Ankara, Turkey ABSTRACT This review outlines important anatomical landmarks not only for rectal cancer surgery but also for pelvic exentration. Keywords: Anorectal anatomy, pelvic anatomy, surgical anatomy of rectum ÖZ Pelvis anatomisini derleme halinde özetleyen bu makale rektum kanser cerrahisi ve pelvik ezantrasyon için önemli topografik noktaları gözden geçirmektedir. Anahtar Kelimeler: Anorektal anatomi, pelvik anatomi, rektumun cerrahi anatomisi Introduction Surgical Anatomy of the Rectum The rectum extends from the promontory to the anal canal Pelvic Anatomy and is approximately 12-15 cm long. It fills the sacral It is essential to know the pelvic anatomy because of the concavity and ends with an anal canal 2-3 cm anteroinferior intestinal and urogenital complications that may develop to the tip of the coccyx. The rectum contains three folds in after the surgical procedures applied to the pelvic region. the coronal plane laterally. The upper and lower are convex The pelvis, encircled by bone tissue, is surrounded by the to the right, and the middle is convex to the left. The middle main vessels, ureters, and autonomic nerves. Success in the fold is aligned with the peritoneal reflection. Intraluminal surgical treatment of pelvic organs is only possible with a projections of the lower boundaries of these folds are known as Houston’s valves. Unlike the sigmoid colon, taenia, good knowledge of the embryological development of the epiploic appendices, and haustra are absent in the rectum. -
Autonomic Nervous System
AUTONOMIC NERVOUS SYSTEM PAGE 1 AUTONOMIC NERVOUS SYSTEM PAGE 2 AUTONOMIC NERVOUS SYSTEM PAGE 3 AUTONOMIC NERVOUS SYSTEM PAGE 4 AUTONOMIC NERVOUS SYSTEM PAGE 5 AUTONOMIC NERVOUS SYSTEM PAGE 6 AUTONOMIC NERVOUS SYSTEM PAGE 7 AUTONOMIC NERVOUS SYSTEM PAGE 8 AUTONOMIC NERVOUS SYSTEM PAGE 9 REVIEW QUESTIONS 1. The autonomic nervous system controls the activity of _?_. (a) smooth muscle (b) cardiac muscle (c) glands (d) all of these (e) none of these 2. All preganglionic and postganglionic autonomic neurons are _?_ neurons. (a) somatic efferent (b) visceral efferent (c) somatic afferent (d) visceral afferent (e) association neurons 3. Which neurotransmitter is released at the synapses between preganglionic and postganglionic autonomic neurons ? (a) epinephrine (b) norepinephrine (c) acetylcholine (d) serotonin (e) oxytocin 4. All preganglionic sympathetic neurons are located in: (a) the lateral horn of the spinal cord of spinal cord segments T1-L2 (b) brainstem nuclei (c) intramural (terminal) ganglia (d) paravertebral ganglia of the sympathetic chains (e) prevertebral ganglia 5. All preganglionic parasympathetic neurons are located in _?_. (a) prevertebral ganglia (b) the lateral horn of spinal cord segments T1-L2 (c) sympathetic chain ganglia (d) intramural ganglia (e) brainstem nuclei and spinal cord segments S2-S4 6. Prevertebral and paravertebral ganglia contain _?_. (a) preganglionic sympathetic neurons (b) preganglionic parasympathetic neurons (c) postganglionic sympathetic neurons (d) postganglionic parasympathetic neurons (e) all of these 7. The otic, ciliary, submandibular and pterygopalatine ganglia are located in the head region and contain _?_. (a) preganglionic sympathetic neurons (b) preganglionic parasympathetic neurons (c) postganglionic sympathetic neurons (d) postganglionic parasympathetic neurons (e) none of these 8. -
The Sympathetic and the Parasympathetic Nervous System
The sympathetic and the parasympathetic nervous system Zsuzsanna Tóth, PhD Institute of Anatomy, Histology and Embryology Semmelweis University The role of the autonomic nervous system Claude Bernard • „milieu intérieur” concept; every organism lives in its internal environment that is constant and independent form the external environment Walter Bradford Cannon homeostasis; • an extension of the “milieu interieur” concept • consistence in an open system requires mechanisms that act to maintain that consistency • steady-state conditions require that any tendency toward change automatically meets with factors that resist that change • regulating systems that determine the homeostatic state : o autonomic nervous system ( sympathetic, parasympathetic, enteral) o endocrine system General structure of the autonomic nervous system craniosacral thoracolumbar Anatomy Neurotransmittersof the gut autonomic nervous system. symp. gangl pregangl. fiber pregangl. postgangl. fiber fiber (PoR) PoR enteral ganglion PoR PoR smooth muscle smooth muscle Kuratani S Development 2009;136:1585-1589 Sympathetic activation: Fight or flight reaction • energy mobilization • preparation for escape, or fight vasoconstriction • generalized Parasympathetic activation: adrenal • energy saving and restoring • „rest and digest” system • more localized vasoconstriction Paravertebral ganglia and the sympathetic chains pars cervicalis superius ganglion medium cervicale stellatum pars vertebrae • from the base of the skull to the caudal end thoracalis thoracalis of the sacrum • paravertebral ganglia (ganglia trunci sympathici) • rami interganglionares pars vertebrae • the two chains fuses at the ganglion impar abdominalis lumbalis sacrum pars pelvina foramen sacralia anteriora ganglion impar Anatomy of the cervical part of the sympathetic trunk superior cervical ganglion • behind the seath of the carotid, fusiform ggl. cervicale superius • IML T1-3 vegetative motoneurons- preganglionic fibers truncus symp. -
The Enteric Nervous System: a Second Brain
The Enteric Nervous System: A Second Brain MICHAEL D. GERSHON Columbia University Once dismissed as a simple collection of relay ganglia, the enteric nervous system is now recognized as a complex, integrative brain in its own right. Although we still are unable to relate complex behaviors such as gut motility and secretion to the activity of individual neurons, work in that area is proceeding briskly--and will lead to rapid advances in the management of functional bowel disease. Dr. Gershon is Professor and Chair, Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York. In addition to numerous scientific publications, he is the author of The Second Brain (Harper Collins, New York, 1998). Structurally and neurochemically, the enteric nervous system (ENS) is a brain unto itself. Within those yards of tubing lies a complex web of microcircuitry driven by more neurotransmitters and neuromodulators than can be found anywhere else in the peripheral nervous system. These allow the ENS to perform many of its tasks in the absence of central nervous system (CNS) control--a unique endowment that has permitted enteric neurobiologists to investigate nerve cell ontogeny and chemical mediation of reflex behavior in a laboratory setting. Recognition of the importance of this work as a basis for developing effective therapies for functional bowel disease, coupled with the recent, unexpected discovery of major enteric defects following the knockout of murine genes not previously known to affect the gut, has produced a groundswell of interest that has attracted some of the best investigators to the field. Add to this that the ENS provides the closest thing we have to a window on the brain, and one begins to understand why the bowel--the second brain--is finally receiving the attention it deserves. -
Pin Faculty Directory
Harvard University Program in Neuroscience Faculty Directory 2019—2020 April 22, 2020 Disclaimer Please note that in the following descripons of faculty members, only students from the Program in Neuroscience are listed. You cannot assume that if no students are listed, it is a small or inacve lab. Many faculty members are very acve in other programs such as Biological and Biomedical Sciences, Molecular and Cellular Biology, etc. If you find you are interested in the descripon of a lab’s research, you should contact the faculty member (or go to the lab’s website) to find out how big the lab is, how many graduate students are doing there thesis work there, etc. Program in Neuroscience Faculty Albers, Mark (MGH-East)) De Bivort, Benjamin (Harvard/OEB) Kaplan, Joshua (MGH/HMS/Neurobio) Rosenberg, Paul (BCH/Neurology) Andermann, Mark (BIDMC) Dettmer, Ulf (BWH) Karmacharya, Rakesh (MGH) Rotenberg, Alex (BCH/Neurology) Anderson, Matthew (BIDMC) Do, Michael (BCH—Neurobio) Khurana, Vikram (BWH) Sabatini, Bernardo (HMS/Neurobio) Anthony, Todd (BCH/Neurobio) Dong, Min (BCH) Kim, Kwang-Soo (McLean) Sahay, Amar (MGH) Arlotta, Paola (Harvard/SCRB) Drugowitsch, Jan (HMS/Neurobio) Kocsis, Bernat (BIDMC) Sahin, Mustafa (BCH/Neurobio) Assad, John (HMS/Neurobio) Dulac, Catherine (Harvard/MCB) Kreiman, Gabriel (BCH/Neurobio) Samuel, Aravi (Harvard/ Physics) Bacskai, Brian (MGH/East) Dymecki, Susan(HMS/Genetics) LaVoie, Matthew (BWH) Sanes, Joshua (Harvard/MCB) Baker, Justin (McLean) Engert, Florian (Harvard/MCB) Lee, Wei-Chung (BCH/Neurobio) Saper, Clifford -
Detailed and Applied Anatomy for Improved Rectal Cancer Treatment
REVIEW ARTICLE Annals of Gastroenterology (2019) 32, 1-10 Detailed and applied anatomy for improved rectal cancer treatment Τaxiarchis Κonstantinos Νikolouzakisa, Theodoros Mariolis-Sapsakosb, Chariklia Triantopoulouc, Eelco De Breed, Evaghelos Xynose, Emmanuel Chrysosf, John Tsiaoussisa Medical School of Heraklion, University of Crete; National and Kapodistrian University of Athens, Agioi Anargyroi General and Oncologic Hospital of Kifisia, Athens; Konstantopouleio General Hospital, Athens; Medical School of Crete University Hospital, Heraklion, Crete; Creta Interclinic, Heraklion, Crete; University Hospital of Heraklion, Crete, Greece Abstract Rectal anatomy is one of the most challenging concepts of visceral anatomy, even though currently there are more than 23,000 papers indexed in PubMed regarding this topic. Nonetheless, even though there is a plethora of information meant to assist clinicians to achieve a better practice, there is no universal understanding of its complexity. This in turn increases the morbidity rates due to iatrogenic causes, as mistakes that could be avoided are repeated. For this reason, this review attempts to gather current knowledge regarding the detailed anatomy of the rectum and to organize and present it in a manner that focuses on its clinical implications, not only for the colorectal surgeon, but most importantly for all colorectal cancer-related specialties. Keywords Anatomy, rectum, cancer, surgery Ann Gastroenterol 2019; 32 (5): 1-10 Introduction the anal verge [AV]) to a given landmark (e.g., the part from the sacral promontory) [1]. This study can be considered as Even though rectal anatomy is considered by most indicative of the current overall knowledge on rectal anatomy clinicians to be a well-known subject, it is still treated as a hot across CRC-related specialties. -
A Narrative Review on the Impact of Nerve Sparing Surgery on Urinary Function in Pelvic Surgery for Endometriosis
5 Review Article Page 1 of 5 A narrative review on the impact of nerve sparing surgery on urinary function in pelvic surgery for endometriosis Beth Leopold1, Jordan S. Klebanoff2, Sara Rahman3, Sofiane Bendifallah4,5,6, Jean Marc Ayoubi7, Gaby N. Moawad3 1Department of Obstetrics and Gynecology, Mount Sinai Medical Center, New York, NY, USA; 2Department of Obstetrics and Gynecology, Main Line Health, Wynewood, PA, USA; 3Department of Obstetrics and Gynecology, The George Washington University Hospital, Washington, DC, USA; 4Department of Gynaecology and Obstetrics, Tenon University Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Sorbonne University, Paris, France; 5UMRS-938, Sorbonne University, Paris, France; 6Groupe de Recherche Clinique 6 (GRC6-Sorbonne Université): Centre Expert En Endométriose (C3E), France; 7Department of Obstetrics and Gyncology and Reproductive Medicine, Hopital Foch, Faculté de Médecine Paris Ouest (UVSQ), Suresnes, France Contributions: (I) Conception and design: B Leopold, JS Klebanoff, GN Moawad; (II) Administrative support: None; (III) Provision of study materials or patients: B Leopold, JS Klebanoff, S Rahman, GN Moawad; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Gaby N. Moawad, MD. Department of Obstetrics & Gynecology, The George Washington University Hospital, 2150 Pennsylvania Ave NW, Washington, DC 20037, USA. Email: [email protected]. Abstract: Endometriosis is an all too common benign inflammatory condition that impacts the lives of countless women around the world. Not only is there typically a delay in diagnosis of this devastating condition, but women are often mismanaged until they reach a provider with expertise in the condition. -
The Neuroanatomy of Female Pelvic Pain
Chapter 2 The Neuroanatomy of Female Pelvic Pain Frank H. Willard and Mark D. Schuenke Introduction The female pelvis is innervated through primary afferent fi bers that course in nerves related to both the somatic and autonomic nervous systems. The somatic pelvis includes the bony pelvis, its ligaments, and its surrounding skeletal muscle of the urogenital and anal triangles, whereas the visceral pelvis includes the endopelvic fascial lining of the levator ani and the organ systems that it surrounds such as the rectum, reproductive organs, and urinary bladder. Uncovering the origin of pelvic pain patterns created by the convergence of these two separate primary afferent fi ber systems – somatic and visceral – on common neuronal circuitry in the sacral and thoracolumbar spinal cord can be a very dif fi cult process. Diagnosing these blended somatovisceral pelvic pain patterns in the female is further complicated by the strong descending signals from the cerebrum and brainstem to the dorsal horn neurons that can signi fi cantly modulate the perception of pain. These descending systems are themselves signi fi cantly in fl uenced by both the physiological (such as hormonal) and psychological (such as emotional) states of the individual further distorting the intensity, quality, and localization of pain from the pelvis. The interpretation of pelvic pain patterns requires a sound knowledge of the innervation of somatic and visceral pelvic structures coupled with an understand- ing of the interactions occurring in the dorsal horn of the lower spinal cord as well as in the brainstem and forebrain. This review will examine the somatic and vis- ceral innervation of the major structures and organ systems in and around the female pelvis. -
MINIREVIEW Posterior Gut Development in Drosophila: a Model System for Identifying Genes Controlling Epithelial Morphogen- Esis
Cell Research (1998), 8, 273-284 MINIREVIEW Posterior gut development in Drosophila: a model system for identifying genes controlling epithelial morphogen- esis LENGYEL JUDITH A* , XUE JUN LIU Department of Molecular, Cell and Developmental Biology University of California at Los Angeles, Los Angeles, CA USA, 90095-1606 USA ABSTRACT The posterior gut of the Drosophila embryo, consist- ing of hindgut and Malpighian tubules, provides a simple, well-defined system where it is possible to use a genetic approach to define components essential for epithelial mor- phogenesis. We review here the advantages of Drosophila as a model genetic organism, the morphogenesis of the ep- ithelial structures of the posterior gut, and what is known about the genetic requirements to form these structures. In overview, primordia are patterned by expression of hi- erarchies of transcription factors; this leads to localized expression of cell signaling molecules, and finally, to the least understood step: modulation of cell adhesion and cell shape. We describe approaches to identify additional genes that are required for morphogenesis of these simple epithelia, particularly those that might play a structural role by affecting cell adhesion and cell shape. Key words: Organogenesis, cell rearrangement, con- vergent extension, hindgut, Malpighian tubule. Advantages of Drosophila Work on Drosophila genetics began 90 years ago, when Thomas Hunt Morgan * Corresponding author: [email protected] Drosophila gut epithelial morphogenesis genes (who later received the Nobel Prize for his work) began studying inheritance in the fruit fly. At that time, the advantage of working with this small organism was that it reproduced rapidly in the laboratory, requiring only a simple growth medium, no special attention, and little expense. -
Thesis Comprises Only My Original Work Towards the Doctor of Philosophy Except Where Indicated in the Preface;
Development, prevalence and treatment of blood pressure abnormalities in spinal cord injury Min Yin Goh ORCID: 0000-0003-2517-7745 Doctor of Philosophy August 2019 Department of Medicine, Austin Health Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne Submitted in total fulfilment of the requirements of the degree of Doctor of Philosophy Abstract Disorders of blood pressure control arise from disruption of the autonomic nervous system and result in symptomatic orthostatic hypotension and large fluctuations in blood pressure. Ambulatory blood pressure monitoring is used in the general population for assessment of blood pressure control and to detect episodes of hypotension. In spinal cord injury (SCI), impaired control of the sympathetic nervous system leads to orthostatic intolerance and autonomic dysreflexia. Smaller studies in restricted populations have examined ambulatory pressures in SCI and observed abnormalities in diurnal blood pressure variation in complete cervical SCI. Altered diurnal blood pressure is associated with abnormalities in diurnal urine production and orthostatic intolerance in autonomic failure. This triad may also occur in SCI to explain the orthostatic intolerance. A retrospective examination of ambulatory pressures of patients with SCI referred for clinically significant blood pressure disorders revealed a high prevalence of abnormalities in diurnal blood pressure and urine production in acute and chronic tetraplegia and in acute paraplegia. To characterise the course of diurnal blood pressure, urine production and orthostatic symptoms in SCI, two prospective studies were performed. First, consecutive patients admitted with acute SCI were screened for recruitment, and consenting volunteers were compared with immobilised and mobilising controls. In the second study, people with chronic SCI (>1 year) living in the community were compared with mobilising controls.