Acrylamide a Review About Its Toxic Effects in the Light of Developmental
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Report of the Advisory Group to Recommend Priorities for the IARC Monographs During 2020–2024
IARC Monographs on the Identification of Carcinogenic Hazards to Humans Report of the Advisory Group to Recommend Priorities for the IARC Monographs during 2020–2024 Report of the Advisory Group to Recommend Priorities for the IARC Monographs during 2020–2024 CONTENTS Introduction ................................................................................................................................... 1 Acetaldehyde (CAS No. 75-07-0) ................................................................................................. 3 Acrolein (CAS No. 107-02-8) ....................................................................................................... 4 Acrylamide (CAS No. 79-06-1) .................................................................................................... 5 Acrylonitrile (CAS No. 107-13-1) ................................................................................................ 6 Aflatoxins (CAS No. 1402-68-2) .................................................................................................. 8 Air pollutants and underlying mechanisms for breast cancer ....................................................... 9 Airborne gram-negative bacterial endotoxins ............................................................................. 10 Alachlor (chloroacetanilide herbicide) (CAS No. 15972-60-8) .................................................. 10 Aluminium (CAS No. 7429-90-5) .............................................................................................. 11 -
National Center for Toxicological Research
National Center for Toxicological Research Annual Report Research Accomplishments and Plans FY 2015 – FY 2016 Page 0 of 193 Table of Contents Preface – William Slikker, Jr., Ph.D. ................................................................................... 3 NCTR Vision ......................................................................................................................... 7 NCTR Mission ...................................................................................................................... 7 NCTR Strategic Plan ............................................................................................................ 7 NCTR Organizational Structure .......................................................................................... 8 NCTR Location and Facilities .............................................................................................. 9 NCTR Advances Research Through Outreach and Collaboration ................................... 10 NCTR Global Outreach and Training Activities ............................................................... 12 Global Summit on Regulatory Science .................................................................................................12 Training Activities .................................................................................................................................14 NCTR Scientists – Leaders in the Research Community .................................................. 15 Science Advisory Board ................................................................................................... -
Chemistry and Safety of Acrylamide in Food ADVANCES in EXPERIMENTAL MEDICINE and BIOLOGY
Chemistry and Safety of Acrylamide in Food ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University of Milan Recent Volumes in this Series Volume 553 BIOMATERIALS: From Molecules to Engineered Tissues Edited by Nesrin Hasirci and Vasif Hasirci Volume 554 PROTECTING INFANTS THROUGH HUMAN MILK: Advancing the Scientific Evidence Edited by Larry K. Pickering, Ardythe L. Morrow, Guillermo M. Ruiz-Palacios, and Richard J. Schanler Volume 555 BREAST FEEEDING: Early Influences on Later Health Edited by Gail Goldberg, Andrew Prentice, Ann Prentice, Suzanne Filteau, and Elsie Widdowson Volume 556 IMMUNOINFORMATICS: Opportunities and Challenges of Bridging Immunology with Computer and Information Sciences Edited by Christian Schoenbach, V. Brusic, and Akihiko Konagaya Volume 557 BRAIN REPAIR Edited by M. Bahr Volume 558 DEFECTS OF SECRETION IN CYSTIC FIBROSIS Edited by Carsten Schultz Volume 559 CELL VOLUME AND SIGNALING Edited by Peter K. Lauf and Norma C. Adragna Volume 560 MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION X: INNATE IMMUNITY Edited by Sudhir Gupta, William Paul, and Ralph Steinman Volume 561 CHEMISTRY AND SAFETY OF ACRYLAMIDE IN FOOD Edited by Mendel Friedman and Don Mottram A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. Chemistry and Safety of Acrylamide in Food Edited by Mendel Friedman Agricultural Research Service, USDA Albany, California and Don Mottram University of Reading Reading, United Kingdom Spriinge r Library of Congress Cataloging-in-Publication Data Chemistry and safety of acrylamide in food/edited by Mendel Friedman and Don Mottram. -
Towards Next Generation Risk Assessment of Chemicals: Bayesian
Towards next generation risk assessment of chemicals : bayesian meta-analysis of human variability in metabolism and transporters and application for the derivation of pathway-related uncertainty factors Keyvin Darney To cite this version: Keyvin Darney. Towards next generation risk assessment of chemicals : bayesian meta-analysis of human variability in metabolism and transporters and application for the derivation of pathway- related uncertainty factors. Toxicology. Université de Bretagne occidentale - Brest, 2020. English. NNT : 2020BRES0013. tel-03227086 HAL Id: tel-03227086 https://tel.archives-ouvertes.fr/tel-03227086 Submitted on 16 May 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. THESE DE DOCTORAT DE L'UNIVERSITE DE BRETAGNE OCCIDENTALE ECOLE DOCTORALE N° 605 Biologie Santé Spécialité : Toxicologie Par Keyvin DARNEY Towards next generation risk assessment of chemicals: Bayesian meta-analysis of Human variability in metabolism and transporters and application for the derivation of pathway-related uncertainty factors Thèse présentée -
Dietary Intake and Biomarkers of Acrylamide Exposure and Risk of Endometrial and Ovarian Cancer
Dietary intake and biomarkers of acrylamide exposure and risk of endometrial and ovarian cancer A molecular epidemiologic study in the European Prospective Investigation into Cancer and Nutrition Mireia Obón Santacana Aquesta tesi doctoral està subjecta a la llicència Reconeixement- NoComercial – SenseObraDerivada 3.0. Espanya de Creative Commons. Esta tesis doctoral está sujeta a la licencia Reconocimiento - NoComercial – SinObraDerivada 3.0. España de Creative Commons. This doctoral thesis is licensed under the Creative Commons Attribution-NonCommercial- NoDerivs 3.0. Spain License. REFERENCE LIST REFERENCE LIST 8. REFERENCE LIST 1. (1986) Acrylamide. IARC Monogr Eval Carcinog Risk Chem Hum 39:41–66. 2. Chen Y-H, Xia E-Q, Xu X-R, et al (2012) Evaluation of Acrylamide in Food from China by a LC/MS/MS Method. Int J Environ Res Public Health 9:4150–4158. doi: 10.3390/ijerph9114150 3. IARC (1994) IARC working group on the evaluation of carcinogenic risks to humans: some industrial chemicals. Lyon, 15-22 February 1994. IARC Monogr EvalCarcinogRisks Hum 60:1–560. 4. Sobel W, Bond GG, Parsons TW, Brenner FE (1986) Acrylamide cohort mortality study. Br J Ind Med 43:785–788. 5. Collins JJ, Swaen GM, Marsh GM, et al (1989) Mortality patterns among workers exposed to acrylamide. J Occup Med 31:614–617. 6. Le Quesne PM (1985) Clinical and morphological findings in acrylamide toxicity. Neurotoxicology 6:17–24. 7. Reynolds T (2002) Acrylamide and cancer: tunnel leak in Sweden prompted studies. J Natl Cancer Inst 94:876–878. 8. Törnqvist M, Bergmark E, Ehrenberg L, Granath F (1998) Risk assessment of acrylamide. -
Heats of Formation of Certain Nickel-Pyridine Complex Salts
HEATS OF FORFATION OF CERTAIN NICKEL-PYRIDINE COLPLEX SALTS DAVID CLAIR BUSH A THESIS submitted to OREGON STATE COLLEGE in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE June l9O [4CKNOWLEDGMENT The writer wishes to acknowledge his indebtedness and gratitude to Dr. [4. V. Logan for his help and encour- agement during this investigation. The writer also wishes to express his appreciation to Dr. E. C. Gilbert for helpful suggestions on the con- struction of the calortheter, and to Lee F. Tiller for his excellent drafting and photostating of the figures and graphs. APPROVED: In Charge of ?ajor Head of Department of Chemistry Chairrian of School Graduate Comrittee Dean of Graduate School Date thesis is presented /11 ' Typed by Norma Bush TABLE OF CONTENTS HISTORICAL BACKGROUND i INTRODUCTION 2 EXPERIMENTAL 5 Preparation of the Compounds 5 Analyses of the Compounds 7 The Calorimeter Determination of the Heat Capacity 19 Determination of the Heat of Formation 22 DISCUSSION 39 41 LITERATURE CITED 42 TABLES I Analyses of the Compounds 8 II Heat Capacity of the Calorimeter 23 III Heat of Reaction of Pyridine 26 IV Sample Run and Calculation 27 V Heat of Reaction of Nickel Cyanate 30 VI Heat of Reaction of Nickel Thiocyanate 31 VII Heat of Reaction of Hexapyridinated Nickel Cyanate 32 VIII Heat of Reaction of Tetrapyridinated Nickel Thiocyanate 33 IX Heat of Formation of the Pyridine Complexes 34 FI GURES i The Calorimeter 10 2 Sample Ijector (solids) 14 2A Sample Ejector (liquids) 15 3 Heater Circuit Wiring Diagram 17 4 heat Capacity of the Calorimeter 24 5 Heat of Reaction of Pyridine 28 6 Heat of Reaction of Hexapyridinated Nickel Cyanate 35 7 Heat of Reaction of Tetrapyridinated Nickel Thiocyanate 36 8 Heat of Reaction of Nickel Cyanate 37 9 Heat of Reaction of Nickel Thiocyanate 38 HEATS OF FOW ATION OF CERTAIN NICKEL-PYRIDINE COMPLEX SALTS HISTORICAL BACKGROUND Compounds of pyridine with inorganic salts have been prepared since 1970. -
United States Patent Office Patented Jan
3,071,593 United States Patent Office Patented Jan. 1, 1963 2 3,071,593 O PREPARATION OF AELKENE SULFES Paul F. Warner, Philips, Tex., assignor to Philips Petroleum Company, a corporation of Delaware wherein each R is selected from the group consisting of No Drawing. Filed July 27, 1959, Ser. No. 829,518 5 hydrogen, alkyl, aryl, alkaryl, aralkyl and cycloalkyl 8 Claims. (C. 260-327) groups having 1 to 8 carbon atoms, the combined R groups having up to 12 carbon atoms. Examples of Suit This invention relates to a method of preparing alkene able compounds are ethylene oxide, propylene oxide, iso sulfides. Another aspect relates to a method of convert butylene oxide, a-amylene oxide, styrene oxide, isopropyl ing an alkene oxide to the corresponding sulfide at rela O ethylene oxide, methylethylethylene oxide, 3-phenyl-1, tively high yields without refrigeration. 2-propylene oxide, (3-methylphenyl) ethylene oxide, By the term "alkene sulfide' as used in this specifica cyclohexylethylene oxide, 1-phenyl-3,4-epoxyhexane, and tion and in the claims, I mean to include not only un the like. substituted alkene sulfides such as ethylene sulfide, propyl The salts of thiocyanic acid which I prefer to use are ene sulfide, isobutylene sulfide, and the like, but also 5 the salts of the alkali metals or ammonium. I especially hydrocarbon-substituted alkene sulfides such as styrene prefer ammonium thiocyanate, sodium thiocyanate, and oxide, and in general all compounds conforming to the potassium thiocyanate. These compounds can be reacted formula with ethylene oxide in a cycloparaffin diluent to produce 20 substantial yields of ethylene sulfide and with little or S no polymer formation. -
National Center for Toxicological Research Annual Report 2019
National Center for Toxicological Research 2019 Annual Report Vision, Mission, and Goals Vision The U.S. Food and Drug Administration’s National Center for Toxicological Research is a global resource for collaboration—providing consultation, training, and innovative scientific solutions in support of FDA’s mission to improve public health. Mission NCTR conducts scientific research to generate data for FDA decision making, and develops and supports innovative tools and approaches that FDA uses to protect and promote individual and public health. NCTR Research Goals 2019 NCTR Annual Report Table of Contents (Please click on any of the sections below to quickly visit that section) 4 Preface ─ Message from the Director 5 Preface ─ About the Annual Report 6 NCTR Organization Structure ─ NCTR Leadership 7 NCTR Organization Structure ─ Research Division Directors 8 NCTR at a Glance 9 NCTR at a Glance ─ Numbers for 2019 12 2019 Research Collaborations 13 Collaborations ─ CDER 15 Collaborations ─ CTP 16 Collaborations ─ CFSAN 17 Collaborations ─ CVM 18 Collaborations ─ ORA 19 Collaborations ─ NIEHS/NTP 20 Science Advisory Board 21 Perinatal Health Center of Excellence 22 Global Summit on Regulatory Science (GSRS) 23 2019 NCTR Research Divisions and Important Accomplishments 24 Biochemical Toxicology 26 Bioinformatics & Biostatistics 28 Genetic & Molecular Toxicology 30 Microbiology 32 Neurotoxicology 34 Systems Biology 36 Office of Scientific Coordination www.fda.gov/nctr Message from the Director Preface The National Center for Toxicological Research (NCTR) is the U.S. Food and Drug Administration’s (FDA) premier laboratory research center focused on all FDA-regulated products. NCTR’s primary goal is to support FDA, a critical component of the Department of Health and Human Services (HHS), in its efforts to promote and protect the health of the American public. -
House Fly Attractants and Arrestante: Screening of Chemicals Possessing Cyanide, Thiocyanate, Or Isothiocyanate Radicals
House Fly Attractants and Arrestante: Screening of Chemicals Possessing Cyanide, Thiocyanate, or Isothiocyanate Radicals Agriculture Handbook No. 403 Agricultural Research Service UNITED STATES DEPARTMENT OF AGRICULTURE Contents Page Methods 1 Results and discussion 3 Thiocyanic acid esters 8 Straight-chain nitriles 10 Propionitrile derivatives 10 Conclusions 24 Summary 25 Literature cited 26 This publication reports research involving pesticides. It does not contain recommendations for their use, nor does it imply that the uses discussed here have been registered. All uses of pesticides must be registered by appropriate State and Federal agencies before they can be recommended. CAUTION: Pesticides can be injurious to humans, domestic animals, desirable plants, and fish or other wildlife—if they are not handled or applied properly. Use all pesticides selectively and carefully. Follow recommended practices for the disposal of surplus pesticides and pesticide containers. ¿/áepé4áaUÁí^a¡eé —' ■ -"" TMK LABIL Mention of a proprietary product in this publication does not constitute a guarantee or warranty by the U.S. Department of Agriculture over other products not mentioned. Washington, D.C. Issued July 1971 For sale by the Superintendent of Documents, U.S. Government Printing Office Washington, D.C. 20402 - Price 25 cents House Fly Attractants and Arrestants: Screening of Chemicals Possessing Cyanide, Thiocyanate, or Isothiocyanate Radicals BY M. S. MAYER, Entomology Research Division, Agricultural Research Service ^ Few chemicals possessing cyanide (-CN), thio- cyanate was slightly attractive to Musca domes- eyanate (-SCN), or isothiocyanate (~NCS) radi- tica, but it was considered to be one of the better cals have been tested as attractants for the house repellents for Phormia regina (Meigen). -
Thiocyanate Pyridine Complexes
W&M ScholarWorks Undergraduate Honors Theses Theses, Dissertations, & Master Projects 5-2017 Structural Comparison of Copper(II) Thiocyanate Pyridine Complexes Joseph V. Handy College of WIlliam & Mary Follow this and additional works at: https://scholarworks.wm.edu/honorstheses Part of the Inorganic Chemistry Commons Recommended Citation Handy, Joseph V., "Structural Comparison of Copper(II) Thiocyanate Pyridine Complexes" (2017). Undergraduate Honors Theses. Paper 1100. https://scholarworks.wm.edu/honorstheses/1100 This Honors Thesis is brought to you for free and open access by the Theses, Dissertations, & Master Projects at W&M ScholarWorks. It has been accepted for inclusion in Undergraduate Honors Theses by an authorized administrator of W&M ScholarWorks. For more information, please contact [email protected]. Structural Comparison of Copper(II) Thiocyanate Pyridine Complexes A thesis submitted in partial fulfillment of the requirement for the degree of Bachelor of Science in Chemistry from The College of William & Mary by Joseph Viau Handy Accepted for ____________________________ ________________________________ Professor Robert D. Pike ________________________________ Professor Deborah C. Bebout ________________________________ Professor David F. Grandis ________________________________ Professor William R. McNamara Williamsburg, VA May 3, 2017 1 Table of Contents Table of Contents…………………………………………………...……………………………2 List of Figures, Tables, and Charts………………………………………...…………………...4 Acknowledgements….…………………...………………………………………………………6 -
Acrylamide in Food
COUNCIL FORFOR AGRICULTURALAGRICULTURAL SCIENCE SCIENCE AND AND TECHNOLOGY—1 TECHNOLOGY NUMBER 32 JUNE 2006 ACRYLAMIDE IN FOOD TASK FORCE MEMBERS: David Lineback, Co- chair, Joint Institute for Food Safety and Applied INTRODUCTION Nutrition, University of Maryland, College Park; studies or from human expo- In April 2002, researchers Michael W. Pariza, Cochair, Food Research sure in the workplace. Before at the Swedish National Food the Swedish study, no data Institute, University of Wisconsin, Madison; Administration and Stockholm were available on the effects of University, using a new analyti- James Coughlin, Coughlin & Associates, La- acrylamide at the low concen- cal procedure, announced they guna Niguel, California; Catherine Davies, trations observed in food (i.e., had discovered the presence of Department of Animal and Food Sciences, Uni- in the microgram (µg)/kilo- acrylamide in foods prepared versity of Delaware, Newark; Beate Kettlitz,* gram (kg) [parts per billion by heating (frying, baking) at BEUC, the European Consumers’ Organization, (ppb)] range). temperatures above 120°C So acrylamide is not new, Brussels, Belgium; Lauren Posnick Robin, (Swedish 2002; Tareke et al. but its presence in food is 2002). Identification of Center for Food Safety and Applied Nutrition, newly discovered. Increased acrylamide in these foods, U.S. Food and Drug Administration, College concern about the effect of which include french fries, po- Park, Maryland; David Schmidt, International acrylamide on human health tato chips (crisps), cookies (bis- -
On the Effects of Urea on the Molecular Structure and Activity of Various
The Journal of Biochemistry, Vol. 58, No. 1, 1965 Effects of Urea on the Activity and Structure of Yeast Alcohol Dehydrogenase By TAKAHISA OHTA* and YASUYUEI OGURA (From the Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Bunkyo-ku, Tokyo) (Received for publication, March 29, 1965) There have been many reports (1-8) on (9) and K lot z (10). However, to interprete the effects of urea on the molecular structure the mechanism of inhibition by urea on enzyme and activity of various enzymes. Most reactions, further investigations are necessary enzymes (1-4) are known to be inhibited by since few have covered both kinetics of the en low concentrations of urea which do not zymatic reaction and physicochemical analysis denature their protein. The mode of inhibi of the structural changes of the enzyme protein. tion of urea on various enzyme reactions has In this paper, the effects of urea upon yeast been studied kinetically by R a j a g o p a l a n, alcohol dehydrogenase [EC 1. 1. 1. 1, Alcohol: Fridovich and Handler (3) and also NAD oxidoreductase (yeast)] have been studi by Chase's group (6-8) using rather low ed, focusing attention on the relationship be concentrations of urea. The inhibition by tween the structure of the enzyme molecule urea of various enzymes, such as xanthine and its catalytic activity. oxidase [EC 1.2.3.2], muscle lactate dehydro EXPERIMENTAL genase [EC 1. 1. 1. 27] (3) and kidney aldose mutarotase [EC 5.1.3.3] (6) has been reported Materials-Yeast alcohol dehydrogenase was prepar to be reversible and competitive for the sub ed from fresh baker's yeast* by the following pro strate.