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(12) United States Patent (10) Patent No.: US 9,636,380 B2 Lammel Et Al

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(12) United States Patent (10) Patent No.: US 9,636,380 B2 Lammel Et Al USOO963638 OB2 (12) United States Patent (10) Patent No.: US 9,636,380 B2 Lammel et al. (45) Date of Patent: May 2, 2017 (54) OPTOGENETIC CONTROL OF INPUTS TO 5,041,224 A 8/1991 Ohyama et al. THE VENTRAL TEGMENTAL AREA 5,082,670 A 1/1992 Gage et al. 5,249,575 A 10, 1993 Di Mino et al. 5,267,152 A 11/1993 Yang et al. (71) Applicant: The Board of Trustees of the Leland 5,290,280 A 3/1994 Daikuzono et al. Stanford Junior University, Palo Alto, 5.330,515 A 7, 1994 Rutecki et al. CA (US) 5,382,516 A 1, 1995 Bush 5,411,540 A 5, 1995 Edell et al. 5,445,608 A 8, 1995 Chen et al. (72) Inventors: Stephan Lammel, Stanford, CA (US); 5,460.950 A 10, 1995 Barr et al. Byungkook Lim, La Jolla, CA (US); 5,460.954 A 10, 1995 Lee et al. Robert C. Malenka, Palo Alto, CA 5,470,307 A 11/1995 Lindall (US) 5,495,541 A 2/1996 Murray et al. 5,520,188 A 5/1996 Hennige et al. 5,527,695 A 6/1996 Hodges et al. 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A 10/2000 Fischell et al. (60) Provisional application No. 61/789,486, filed on Mar. 6,161,045. A 12/2000 Fischell et al. 15, 2013, provisional application No. 61/890,000, 6,180,613 B1B 1/2001 Kaplitt et al. filed on Oct. 11, 2013. (Continued) (51) Int. Cl. FOREIGN PATENT DOCUMENTS A6 IK 49/00 (2006.01) A6 IK 38/17 (2006.01) CN 107.9464 A 12/1993 EP 1334748 8, 2003 (52) U.S. Cl. EP 1873566 1, 2008 CPC ........ A61K 38/177 (2013.01); A61K 49/0008 JP 629.5350 10, 1994 (2013.01) JP 2004534508 11 2004 (58) Field of Classification Search JP 2005034O73. A 2, 2005 JP 2010227537 A 10, 2010 CPC ...... A61K 38/00; A61K 38/177; A61K 49/00; JP 2012508581 4/2012 A61K 49/0008: A61K 48/00; A61 K WO WO 96/32O76 10, 1996 51/00; A61K 51/08: A61K 51/088: A61 K 51/0491; A61K 2123/00; A61K 2121/00; (Continued) A61K 51/0478: A61K 51/1234: A61 K 9/0078: A61K 49/0004: CO7F 13/005; OTHER PUBLICATIONS A01K 2217/05; G01N 33/5088 Babin et al., "Zebrafish Models of Human Motor Neuron Diseases: USPC ... 424/1.11, 1.65, 1.69, 9.1, 9.2: 514/1, 1.1, Advantages and Limitations'. Progress in Neurobiology (2014), 514/17.7, 17.8, 17.9, 18.1, 21.2, 21.3; 118:36-58. 530/300, 324, 325, 350 See application file for complete search history. (Continued) Primary Examiner — D L. Jones (56) References Cited (74) Attorney, Agent, or Firm — Bozicevic, Field & U.S. PATENT DOCUMENTS Francis LLP, Paula A. Borden 2.968,302 A 1/1961 Fry et al. (57) ABSTRACT 3,131,690 A 5, 1964 Innis et al. The present disclosure provides a method of inducing or 3,499.437 A 3, 1970 Balamuth et al. 3,567,847. 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