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A61K 38/00; A61K 38/177; A61K 49/00; JP 2012508581 4/2012 A61K 49/0008: A61K 48/00; A61 K WO WO 96/32O76 10, 1996 51/00; A61K 51/08: A61K 51/088: A61 K 51/0491; A61K 2123/00; A61K 2121/00; (Continued) A61K 51/0478: A61K 51/1234: A61 K 9/0078: A61K 49/0004: CO7F 13/005; OTHER PUBLICATIONS A01K 2217/05; G01N 33/5088 Babin et al., "Zebrafish Models of Human Motor Neuron Diseases: USPC ... 424/1.11, 1.65, 1.69, 9.1, 9.2: 514/1, 1.1, Advantages and Limitations'. Progress in Neurobiology (2014), 514/17.7, 17.8, 17.9, 18.1, 21.2, 21.3; 118:36-58. 530/300, 324, 325, 350 See application file for complete search history. (Continued) Primary Examiner — D L. Jones (56) References Cited (74) Attorney, Agent, or Firm — Bozicevic, Field & U.S. PATENT DOCUMENTS Francis LLP, Paula A. Borden 2.968,302 A 1/1961 Fry et al. (57) ABSTRACT 3,131,690 A 5, 1964 Innis et al. The present disclosure provides a method of inducing or 3,499.437 A 3, 1970 Balamuth et al. 3,567,847. 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