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SCIENCE HISTORY INSTITUTE ISABELLA KARLE and JEROME
SCIENCE HISTORY INSTITUTE ISABELLA KARLE and JEROME KARLE Transcript of an Interview Conducted by James J. Bohning and David K. Van Keuren at Naval Research Laboratory Washington, District of Columbia on 26 February, 15 June and 9 September 1987 (With Subsequent Corrections and Additions) Upon Isabella Karle’s death in 2017, this oral history was designated Free Access. Please note: This oral history is protected by U.S. copyright law and shall not be reproduced or disseminated in any way without the express permission of the Science History Institute. Users citing this interview for purposes of publication are obliged under the terms of the Center for Oral History, Science History Institute, to credit the Science History Institute using the format below: Isabella Karle and Jerome Karle, interview by James J. Bohning and David K. Van Keuren at Naval Research Laboratory, Washington, District of Columbia, 26 February, 15 June and 9 September 1987 (Philadelphia: Science History Institute, Oral History Transcript # 0066). Formed by the merger of the Chemical Heritage Foundation and the Life Sciences Foundation, the Science History Institute collects and shares the stories of innovators and of discoveries that shape our lives. We preserve and interpret the history of chemistry, chemical engineering, and the life sciences. Headquartered in Philadelphia, with offices in California and Europe, the Institute houses an archive and a library for historians and researchers, a fellowship program for visiting scholars from around the globe, a community of researchers who examine historical and contemporary issues, and an acclaimed museum that is free and open to the public. For more information visit sciencehistory.org. -
Commencement Friday, June 1, 2018
THE CITY COLLEGE OF NEW YORK COMMENCEMENT FRIDAY, JUNE 1, 2018 THE CITY UNIVERSITY OF NEW YORK Commencement Friday, June 1, 2018, 9:30 a.m. South Campus Great Lawn Presiding Vince Boudreau President, The City College of New York Academic Procession Interim Provost Tony Liss Taimoor Arif President, Undergraduate Student Government Cyrille Njikeng Executive Chair, Graduate Student Council Associate Dean Ardie Walser The Grove School of Engineering Ph.D Graduates Interim Dean Kevin Foster Colin Powell School for Civic and Global Leadership Faria Tasnim and Tyler Walls Dean Erec Koch The Division of Humanities and the Arts Sophie Ziner and Lucius Seo Dean Maurizio Trevisan The Sophie Davis Program in Biomedical Education in the CUNY School of Medicine Samantha Lau and Gabriella Schmuter Acting Dean V. Parameswaran Nair The Division of Science Lisa Lopez and Lucy Lopez Acting Dean Gordon Gebert The Bernard and Anne Spitzer School of Architecture Jun Nam and Gabriel Morales Director Hillary Brown Sustainability in the Urban Environment Michael Duffy, Evelyn Levine and Robin Perl Dean Mary Erina Driscoll The School of Education Massiel A. De León de la Serna and Samson Baker Dean Juan Carlos Mercado The Division of Interdisciplinary Studies at the Center for Worker Education Gabrielle Gallo and Jose Miranda Dean Gilda Barabino The Grove School of Engineering Vivakeanand “Vishal” Boodhan and Joseph Rettberg Academic Procession Faculty (continued) Reunion Classes 1978, 1968, 1958 and 1948 President’s Platform Party Deans and Vice Presidents of the College Student Government Leaders Valedictorian Salutatorian Honored Guests Interim Provost Tony Liss Chief Marshal Janet Steele President Vince Boudreau The Color Guard of the CUNY Army ROTC Program presents the National Colors The National Anthem Megumi Toyama BFA in Jazz Vocal Studies Greetings Fernando Ferrer The Board of Trustees The City University of New York Chancellor James B. -
INCITE IR FINAL 7-19-11.Pdf
Contents 3 INCITE Accelerates Research Breakthroughs PRODUCTION TEAM with Leadership Computing Team Leader: Julia C. White 5 Modeling Turbulent Combustion Speeds Design of Power and Propulsion Devices Publication Director: Dawn Levy 7 Advanced Computing Aids Design Editors: Priscilla Henson, Dawn Levy of Next-Generation Nuclear Reactors Contributing Science Writers: Cheryl 9 Breakthrough Fusion Simulations Drugan, Eric Gedenk, Kathryn Jandeska, Shed Light on Plasma Confinement Scott Jones, Dawn Levy, Caitlin Rockett, Leo Williams, Laura Wolf 11 Chemistry and Materials Computations Speed Clean Energy Production and Storage Graphic Designer: Jason Smith 13 Jaguar Supercomputer Performs Reviewers: Arthur Bland, Susan Coghlan, Most Advanced Earthquake Simulation James J. Hack, Bronson Messer, Paul Messina, Michael Papka, Katherine Riley, 15 Leadership Computing Enables New Insights Julia C. White into the Flow Properties of Concrete Advisors: Ashley Barker, Jayson Hines, 17 Elucidation of Stress Corrosion David Martin Cracking Mechanisms 19 High-Performance Computing Provides CONTACT First Simulation of Abrupt Climate Change Julia C. White INCITE Manager 21 Supercomputers Predict the Structures Phone: 865-241-8796 of Large Proteins Key in Health [email protected] 23 Simulations Spur Scientists to Revise Theory of How Stars Explode and a Pulsar Gets Its Spin 25 Scientists Model the Molecular Basis of Parkinson’s Disease The research described herein was made possible through awards of computer time 27 Unprecedented Simulation Lessens the Risk provided through the Innovative and Novel Computational Impact on Theory and of Combustion Instabilities in Turbines Experiment (INCITE) program. The research used either resources of the Oak Ridge Leadership Computing Facility, located in the National Center for Computational Sciences at Oak Ridge National Laboratory and supported by the Office of Science of the U.S. -
Biomolecular Modeling Thrives in the Age of Technology
PERSPECTIVE https://doi.org/10.1038/s43588-021-00060-9 Biomolecular modeling thrives in the age of technology Tamar Schlick 1,2,3 ✉ and Stephanie Portillo-Ledesma1 The biomolecular modeling field has flourished since its early days in the 1970s due to the rapid adaptation and tailoring of state-of-the-art technology. The resulting dramatic increase in size and timespan of biomolecular simulations has outpaced Moore’s law. Here, we discuss the role of knowledge-based versus physics-based methods and hardware versus software advances in propelling the field forward. This rapid adaptation and outreach suggests a bright future for modeling, where the- ory, experimentation and simulation define three pillars needed to address future scientific and biomedical challenges. he trajectory of the field of biomolecular modeling and Problems range from unraveling the folding pathways of proteins simulation is a classic example of success driven by an and identification of new therapeutic targets for common human Teclectic mixture of ideas, people, technology and serendip- diseases to the design of novel materials and pharmaceuticals. With ity. From the early days of simulations and force-field develop- the recent emergence of the coronavirus pandemic, all these tools ment through pioneering applications to structure determination, are being utilized in numerous community efforts for simulating enzyme kinetics and molecular dynamics simulations, the field COVID-19 related systems. Similar to the exponential growth so has gone through notable highs and lows1 (Fig. 1). The 1980s were familiar to us now in connection with the spread of COVID-19 marked by advances made possible by supercomputers2,3, and, at infections, exponential progress is only realized when we take stock the same time, by deflated high expectations when it was realized of long timeframes. -
April 8-11, 2019 the 2019 Franklin Institute Laureates the 2019 Franklin Institute AWARDS CONVOCATION APRIL 8–11, 2019
april 8-11, 2019 The 2019 Franklin Institute Laureates The 2019 Franklin Institute AWARDS CONVOCATION APRIL 8–11, 2019 Welcome to The Franklin Institute Awards, the range of disciplines. The week culminates in a grand oldest comprehensive science and technology medaling ceremony, befitting the distinction of this awards program in the United States. Each year, the historic awards program. Institute recognizes extraordinary individuals who In this convocation book, you will find a schedule of are shaping our world through their groundbreaking these events and biographies of our 2019 laureates. achievements in science, engineering, and business. We invite you to read about each one and to attend We celebrate them as modern day exemplars of our the events to learn even more. Unless noted otherwise, namesake, Benjamin Franklin, whose impact as a all events are free and open to the public and located scientist, inventor, and statesman remains unmatched in Philadelphia, Pennsylvania. in American history. Along with our laureates, we honor Franklin’s legacy, which has inspired the We hope this year’s remarkable class of laureates Institute’s mission since its inception in 1824. sparks your curiosity as much as they have ours. We look forward to seeing you during The Franklin From shedding light on the mechanisms of human Institute Awards Week. memory to sparking a revolution in machine learning, from sounding the alarm about an environmental crisis to making manufacturing greener, from unlocking the mysteries of cancer to developing revolutionary medical technologies, and from making the world III better connected to steering an industry giant with purpose, this year’s Franklin Institute laureates each reflect Ben Franklin’s trailblazing spirit. -
CCB 024.Pdf (4.528Mb)
DEPARTMENT OF CHEMISTRY CORNELL UNIVERSITY ITHACA, NEW YORK 14853 U.S.A. NEW SL. ETT E R Issue No. 24 March 1979 Vincent du Vigneaud 1901 - 1978 Vincent ("Dee") du Vigneaud (1901 - 1978) "Dee" du Vigneaud joined our department in Ithaca after a long and illustrious career as Head of the Biochemistry Department of the Cornell Medical College in New York City. He was trained initially as an organic chemist, having done M.S. work at the University of Illinois with "Speed" Marvel, who was also the Ph.D. mentor of our late colleague Al Blomquist. In fact# it was Al who made the first moves that culminated in Dee's coming to Ithaca. While at Illinois, Dee supported himself by teaching equitation, an interest he maintained throughout his life. During this period, he was fortunate to meet and marry Zella Zon Ford who, with Dee, is re- membered as a congenial friend and gracious host. It was at Illinois, too, that his interest in Biochemistry was kindled, and he subsequently did his Ph.D. research in this field by working on the chemistry of insulin at the University of Rochester. After receiving his Ph.D. degree in 1927, he did postdoctoral work with John Abel at Johns Hopkins, Max Bergmann in Dresden, George Barger in Edinburgh and Charles Harington in London. His independent professional career began with an Assistant Professorship in Physiological Chemistry at Illinois (1930- 1932), after which he became in succession Head of the Biochemistry Department of the George Washington School of Medicine (1932-1938), and Head of the Biochemistry Department at the Cornell Medical College (1938-1967). -
CCB 005.Pdf (4.016Mb)
DEPARTMENT OF CHEMISTRY CORNELL UNIVERSITY ITHACA, NEW YORK 14850 /VEWSLET Issue No. 5 February 1970 In planning this issue of the Newsletter, I looked back at last August's issue. I started off by saying that "much has occurred since the last issue of the Newsletter11. These words again are very appropriate. I am sure you all know that Dale R. Corson was elect- ed as the eighth president of Cornell by the Trustees soon after the Newsletter went out last August. President Corson had served as Provost of the University for a number of years before assuming the presidency. President Corson then called on Bob Plane, Chairman of the Chemistry Department, to serve as Provost. Bob decided to take the job as Acting Provost on a one-year basis. Because Bob would only be gone temporarily, it was decided to operate the De- partment with what I call a "troika" * Instead of having a specific person as acting chairman, three people served in this capacity. These people were Don Cooke, Jerry Meinwald and Ben Widom. Just after Christmas, Bob Plane announced that he had decided to take the Provost's job on a permanent basis. This means that he will still be Professor of Chemistry and maintain a research group; but will be spending virtually full-time as Provost which, in effect, is second-in-command of the University. This is a considerable loss to the Department; but a gain for the University and we are very confident that Bob will do an excellent job. Upon assuming the permanent position of Provost, Bob Plane resigned as Chairman of the Chemistry Department. -
Cornell Chemistry
CORNELL CHEMISTRY EXECUTIVE DIRECTOR'S COLUMN Here is the special issue of the Newsletter in which we report on where the respondents to our 1982 questionnaires live and what they do. Future information of this kind will be reported in a column in regular issues of the Newsletter, You will note that there are two alphabetical lists. We won't bother you with the dull story of why our word proces- sor refused to merge the two lists. Be assured, it was the machine's fault, not ours! THE NEWSLETTER A very moving Memorial Service was held for Michell Joseph Sienko in Sage Chapel on Campus on 18 December 1984. The OF THE Reverend Jack Lewis conducted the service. Ben Widom, David DEPARTMENT OF Johnson and Robert Plane spoke in tribute. The readings CHEMISTRY were chosen by Mike's daughter, Tanya. Musical selections by Corelli, Bach and Chopin were played by Mike's colleagues AND THE SOCIETY OF and students. CORNELL CHEMISTS Cornell University The program for the Symposium to commemorate the 100th anniversary of the birth of Peter Debye is now complete. Baker Laboratory The speakers and titles of their lectures are as follows: Ithaca, New York 14853 Mansel Davies, "Peter Debye: Roots and Achievements in Europe - A Summary"; Linus Pauling, "The Nature of the Bonds Formed by Atoms of Transition Metals"; E. Bright Wilson, "Extraction of Barriers to Internal Motion and Other Information About Reaction Paths from Spectroscopic Data, with Malonaldehyde as an Example"; Mark Kac, "Is There a Quantum Langevin Equation?"; Paul J. Flory, "Recent Investigations on the Configurations of Chain Molecules"; Manfred Eigen, "Experiments on Biogenesis". -
Researchers Provide Evidence of How Proteins Fold 1 September 2006
Researchers Provide Evidence of How Proteins Fold 1 September 2006 nonpolar (hydrophobic) pockets that are protected from the water. "What drives this polypeptide chain to fold up?" asked Harold Scheraga, professor emeritus of chemistry and chemical biology at Cornell and a co- author of a paper published in the Aug. 29 issue of the Proceedings of the National Academy of Sciences. "That has been the subject of my investigations for some time, and the cited experimental verification of the theory provides a sound basis for further computational work to identify the specific steps in the folding pathway. "Protein folding is a frontier problem in protein This illustration shows a designed protein transformed chemistry," said Scheraga, noting that an ability to from an unfolded into a folded form. Credit: Adam Liwo predict how and where proteins fold could lead to understanding such protein misfolding diseases as Alzheimer's and cystic fibrosis, designing drugs that act on proteins and even creating designer proteins Experimental evidence provided by a Cornell with new functions. researcher and colleagues at the Scripps Research Institute in La Jolla, Calif., support a long- The theory is based on two methods to show that held theory of how and where proteins fold to initial folding sites occur among nonpolar groups in create their characteristic shapes and biological a polypeptide chain. Lead author H. Jane Dyson functions. and Peter Wright, both professors of molecular biology at the Scripps Research Institute, used an The theory proposes that proteins start to fold in experimental nuclear magnetic resonance specific places along an amino acid chain (called a procedure to validate the predicted results of the polypeptide chain) that contains nonpolar groups, two theoretical methods. -
Université Du Québec À Montréal Mémoires Sous
UNIVERSITÉ DU QUÉBEC À MONTRÉAL MÉMOIRES SOUS SILENCE : LA FRANCE BOMBARDÉE PAR LES ALLIÉS 1940-2014 THÈSE PRÉSENTÉE COMME EXIGENCE PARTIELLE AU DOCTORAT EN HISTOIRE PAR VICTOR BISSONNETTE JUILLET 2020 UNIVERSITÉ DU QUÉBEC À MONTRÉAL Service des bibliothèques Avertissement La diffusion de cette thèse se fait dans le respect des droits de son auteur, qui a signé le formulaire Autorisation de reproduire et de diffuser un travail de recherche de cycles supérieurs (SDU-522 – Rév.10-2015). Cette autorisation stipule que «conformément à l’article 11 du Règlement no 8 des études de cycles supérieurs, [l’auteur] concède à l’Université du Québec à Montréal une licence non exclusive d’utilisation et de publication de la totalité ou d’une partie importante de [son] travail de recherche pour des fins pédagogiques et non commerciales. Plus précisément, [l’auteur] autorise l’Université du Québec à Montréal à reproduire, diffuser, prêter, distribuer ou vendre des copies de [son] travail de recherche à des fins non commerciales sur quelque support que ce soit, y compris l’Internet. Cette licence et cette autorisation n’entraînent pas une renonciation de [la] part [de l’auteur] à [ses] droits moraux ni à [ses] droits de propriété intellectuelle. Sauf entente contraire, [l’auteur] conserve la liberté de diffuser et de commercialiser ou non ce travail dont [il] possède un exemplaire.» REMERCIEMENTS Ce travail doit beaucoup à plusieurs. Bien entendu, les encouragements constants, les nombreuses discussions, les relectures fréquentes du directeur de thèse, le professeur Andrew Barros viennent en premier lieu. Tout ce qui se retrouve ici a été sujet à ses critiques, a bénéficié de ses suggestions, de ses remises en question. -
History of Military Tactics — That of the Ruhr Pocket
HISTORY OF THE UNITED STATES ARMY THE COMMAND AND STAFF COLLEGE LIBRARY Class Accession Number ._.__. „..„ }~ 4.6 RHINEPROVINCE MILITARY DISTRICT FIFTEENTH U. S. ARMY SHOWING: TWENTY FIRST 1. AREA ACQUIRED xxxxx TWELFTH 2. ARMY FROM WHICH AREA WAS ACQUIRED 3. DATE OF TAKE-OVER LEGEND 25 APR JINTH ARMY RHINEPROVINCE BDRY REGIERUNGS BEZIRKE BDRY ACQUIRED AREA BDRY DU/SBUR 31 MAR NINTH ARMY DUSSELDORF 30 MAR NINTH ARMY KOLN 25 APR 30 MAR FIRST ARMY FIRST ARMY 3 APR FIRST ARM 8 APR FIRST ARMY FIRST ARMY THIRD ARMY 10 APR THIRD ARMY 20 APR THIRD ARMY 5 25 A SIXTH SEVENTH 25 APR VENTH ARMY 25 APR SEVENTH ARMY 24 APR SEVENTH ARMY SCALE 1 : 1500000 15 20 25 100 MILES 7 I HISTORY of the FIFTEENTH UNITED STATES ARMY 21 August 1944 to 11 July 1945 ! 3'4B Lieutenant General LEONARD T. GEROW Photo taken in December, 1944, when Lt. General (then Major General) Gerow was commanding the V Corps in the "Battle of the Ardennes" FOREWORD The Fifteenth United States Army was the last Allied army to enter the conflict against Germany, arriving on the Continent during the latter part of December 1944. Yet during the few short months of operations, it met with and solved a host of varied problems in a singulary efficient manner. Its per sonnel can well be proud of the contribution it made to both the war effort and the preliminary stages of German occupation. The Fifteenth Army shared in the preparation of detailed plans for the occupation of the Bremen-Bremerhaven Enclave; it conducted the Meuse River survey, with the view of assuming responsibility for the defense of that line in the event of an enemy breakthrough; it prepared the Berlin District Plan. -
Foch, Le « Journal De Front » D'une Unité Contre L’Influence De La Des Forces Françaises De L'ouest
Mémoire et réflexions Il y a soixante-dix ans Quelques dates pour se souvenir Disparition de Renée Bédarida Dans cette rubrique, nous poursuivons, pendant toute la durée du 70e anniversaire, l’évocation des grands événements ayant marqué la Résistance intérieure. Renée Bédarida, membre du jury du prix Cette chronologie n’a bien sûr rien d’exhaustif et n’a pour seule ambition Philippe Viannay-Défense de la France que de rappeler quelques grandes dates jalonnant son histoire. est décédée le 10 février dernier. Étudiante à Lyon pendant Premier trimestre 1945 la guerre, Renée Bédarida s’était enga- gée dans la Résis- 9 mars 1945 force en Indochine, car celle-ci devient alors un tance au sein du Coup de force japonais en Indochine. Les territoire stratégique pour les communications mouvement Témoi- Japonais y disposent de 60 000 soldats, en vertu du Japon avec les pays qu’il occupe encore gnage chrétien et des accords de coopération militaire et écono- en Asie du Sud-Est. Le 9 mars, les Japonais en contribuant aux mique concédés depuis 1940 par le gouverneur adressent un ultimatum aux Français, puis sans actions clandestines du territoire, l’amiral Decoux, partisan zélé de attendre son expiration attaquent partout les de L’Amitié chré- DR la Révolution nationale. En 1944, pour éviter troupes françaises, sous-équipées et en infé- tienne. Ses activités la main-mise du Japon sur l’Indochine après la riorité numérique. Après quarante-huit heures multiples allèrent de la manifestation contre chute de Vichy, le Gouvernement provisoire de de combat, près de 37 000 Français sont faits la projection du film Le Juif Süss au travail la République française a maintenu Decoux en prisonniers (12 000 militaires et 25 000 civils).