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BMPR1B, Bone Morphogenetic Protein Re- Ceptor Type IB Polyclonal Antibody He Bone Morphogenetic Protein Receptors (BMPR) Are a Or Research Use Only

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BMPR1B, Bone Morphogenetic Protein Re- Ceptor Type IB Polyclonal Antibody He Bone Morphogenetic Protein Receptors (BMPR) Are a Or Research Use Only BMPR1B, Bone morphogenetic protein re- ceptor type IB polyclonal antibody he bone morphogenetic protein receptors (BMPR) are a or Research Use Only. Not for Tfamily of transmembrane serine/threonine kinases that in- FDiagnostic or Therapeutic Use. clude the type I receptors BMPR1A and BMPR1B and the type Purchase does not include or carry II receptor BMPR2. These receptors are also closely related to any right to resell or transfer this the activin receptors (ACVR), ACVR1 and ACVR2. The ligands product either as a stand-alone product or as a component of another of these receptors are members of the TGF-beta superfamily. product. Any use of this product other TGF-beta proteins and activins transduce their signals through than the permitted use without the the formation of heteromeric complexes with two different types express written authorization of Allele of serine/threonine kinase receptors: type I receptors of about Biotech is strictly prohibited 50-55 kD and type II receptors of about 70-80 kD. Type II recep- tors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas Website: www.allelebiotech.com type I receptors require their respective type II receptors for li- Call: 1-800-991-RNAi/858-587-6645 gand binding. Mutations in BMPR1B have been associated with (Pacific Time: 9:00AM~5:00PM) primary pulmonary hypertension. Email: [email protected] Buffers Box 1 | Basic Info Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein Cat. No. ABP-PAB-10537 G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis Animal ID RB1803-1804 against PBS. Host Rabbit Reactivity Human, Mouse Immunogen Format Purified Accession number NM_001203 KLH conjugated synthetic peptide comprised of amino acids 17 - 32 [DGESTAPTPRPKVLRC] of the human bone morphoge- Amount 100µg netic protein receptor type IB (BMPR1B) protein. Alternative Name(s): Application serine/threonine receptor kinase ALK-6, BMPR1B Tested by peptide-specific ELISA (1:1,000). WB (1:100 ~1:500) Storage Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles. References: 1. Astrom AK, Jin D, Imamura T, Roijer E, Rosenzweig B, Miyazono K, ten Dijke P, Stenman G: Chromosomal localiza- tion of three human genes encoding bone morphogenetic protein receptors. Mamm. Genome 10(3): 299-302 (1999). 2. Ide H, Saito-Ohara F, Ohnami S, Osada Y, Ikeuchi T, Yoshida T, Terada M: Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23-->q24 byin situ hybridization and radiation hybrid mapping. Cytogenet. Cell. Genet. 81(3-4): 285-286 (1998). 3. Ide H, Katoh M, Sasaki H, Yoshida T, Aoki K, Nawa Y, Osada Y, Sugimura T, Terada M: Cloning of human bone mor- phogenetic protein type IB receptor (BMPR-IB) and its expression in prostate cancer in comparison with other BMPRs. Oncogene 14(11): 1377-1382 (1997). 4. ten Dijke P, Yamashita H, Ichijo H, Franzen P, Laiho M, Miyazono K, Heldin CH: Characterization of type I receptors for transforming growth factor-beta and activin. Science 264(5155): 101-104 (1994). Allele Biotech-Introducing Cost Effectiveness to Research.
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