Development and Cancer: At the Crossroads of Nodal and Notch Insulin Receptor Substrate-1 Suppresses Transforming Growth Signaling. Luigi Strizzi, Katharine M. Hardy, Elisabeth A. Seftor, Factor-␤1–Mediated Epithelial-Mesenchymal Transition. Fabricio F. Costa, Dawn A. Kirschmann, Richard E.B. Seftor, Jian Shi, Dong-Mei Wang, Chun-Mei Wang, Ying Hu, Ai-Hua Liu, Lynne-Marie Postovit, and Mary J.C. Hendrix...... 7131 Yong-Lian Zhang, Bing Sun, and Jian-Guo Song ...... 7180

Epithelial-Mesenchymal Transition and Cell Cooperativity in Mouse Mammary Tumor Virus p75 and p110 CUX1 Transgenic Metastasis. Takanori Tsuji, Soichiro Ibaragi, and Guo-fu Hu ...... 7135 Mice Develop Mammary Tumors of Various Histologic Types. Advances in Ewing’s Sarcoma Research: Where Are We Now and Chantal Cadieux, Valérie Kedinger, Lu Yao, Charles Vadnais, What Lies Ahead? José Luis Ordóñez, Daniel Osuna, David Herrero, Maria Drossos, Marilène Paquet, and Alain Nepveu...... 7188 Enrique de Álava, and Juan Madoz-Gúrpide ...... 7140 NEDD9 Promotes Oncogenic Signaling in Mammary Tumor Development. Eugene Izumchenko, Mahendra K. Singh, Perspectives in Cancer Research Olga V. Plotnikova, Nadezhda Tikhmyanova, Joy L. Little, Ilya G. Serebriiskii, Sachiko Seo, Mineo Kurokawa, Brian L. Egleston, Andres Klein-Szanto, Elena N. Pugacheva, Richard R. Hardy, Behavioral Oncology and the War on Cancer: Partnering with Marina Wolfson, Denise C. Connolly, and Erica A. Golemis...... 7198 Biomedicine. Michael E. Stefanek, Michael A. Andrykowski, Caryn Lerman, Sharon Manne, and Karen Glanz on behalf of the AACR Behavioral Science Task Force...... 7151 A Genetic Variant of Aurora Kinase A Promotes Genomic Instability Leading to Highly Malignant Skin Tumors. Enrique C. Torchia, Yiyun Chen, Hong Sheng, Hiroshi Katayama, James Fitzpatrick, William R. Brinkley, Carlos Caulin, Subrata Sen, and Dennis R. Roop...... 7207 Meeting Report

Tumor Immunology: New Perspectives. Stephanie E. McArdle Epigenetic Loss of Mucosa-Associated Lymphoid Tissue 1 and Robert C. Rees ...... 7157 Expression in Patients with Oral Carcinomas. Tadashige Chiba, Genta Maeda, Shuichi Kawashiri, Koroku Kato, and Kazushi Imai ...... 7216

Priority Reports Tuberous Sclerosis Complex Suppression in Cerebellar Development and Medulloblastoma: Separate Regulation of Mammalian Target mTOR Signal and Hypoxia-Inducible Factor-1␣ Regulate CD133 of Rapamycin Activity and p27Kip1 Localization. Bobby Bhatia, Expression in Cancer Cells. Kazuko Matsumoto, Tokuzo Arao, Paul A. Northcott, Dolores Hambardzumyan, Baskaran Govindarajan, Kaoru Tanaka, Hiroyasu Kaneda, Kanae Kudo, Yoshihiko Fujita, Daniel J. Brat, Jack L. Arbiser, Eric C. Holland, Michael D. Taylor, Daisuke Tamura, Keiichi Aomatsu, Tomohide Tamura, Yasuhide Yamada, and Anna Marie Kenney ...... 7224 Nagahiro Saijo, and Kazuto Nishio...... 7160 miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Mitochondrial Expression and Functional Activity of Breast Cancer Hormone-Dependent and Hormone-Independent Prostate Cancer Resistance Protein in Different Multiple Drug-Resistant Cell Lines. Growth. Judit Ribas, Xiaohua Ni, Michael Haffner, Erik A. Wentzel, Michela Solazzo, Ornella Fantappiè, Massimo D’Amico, Chiara Sassoli, Amirali Hassanzadeh Salmasi, Wasim H. Chowdhury, Alessia Tani, Greta Cipriani, Costanza Bogani, Lucia Formigli, Tarana A. Kudrolli, Srinivasan Yegnasubramanian, Jun Luo, and Roberto Mazzanti ...... 7235 Ron Rodriguez, Joshua T. Mendell, and Shawn E. Lupold ...... 7165 Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis Clear Differences in Levels of a Formaldehyde-DNA Adduct and Vasculogenesis via Vascular Endothelial Growth Factor and in Leukocytes of Smokers and Nonsmokers. Mingyao Wang, Stromal-Derived Factor 1. Chris Folkins, Yuval Shaked, Shan Man, Guang Cheng, Silvia Balbo, Steven G. Carmella, Peter W. Villalta, Terence Tang, Christina R. Lee, Zhenping Zhu, Robert M. Hoffman, and Stephen S. Hecht ...... 7170 and Robert S. Kerbel ...... 7243 KDR Activating Mutations in Human Angiosarcomas Are Sensitive to Specific Kinase Inhibitors. Cristina R. Antonescu, Matrix Metalloproteinase 12 Overexpression in Lung Epithelial Akihiko Yoshida, Tianhuo Guo, Ning-En Chang, Lei Zhang, Cells Plays a Key Role in Emphysema to Lung Bronchioalveolar Narasimhan P. Agaram, Li-Xuan Qin, Murray F. Brennan, Adenocarcinoma Transition. Peng Qu, Hong Du, Xi Wang, Samuel Singer, and Robert G. Maki ...... 7175 and Cong Yan ...... 7252

Irradiation Alters Selection for Oncogenic Mutations in Hematopoietic Progenitors. Andriy Marusyk, Matias Casás-Selves, Molecular Biology, Pathobiology, and Genetics Curtis J. Henry, Vadym Zaberezhnyy, Jelena Klawitter, Uwe Christians, Mutation-Independent Anaplastic Lymphoma Kinase Overexpression and James DeGregori...... 7262 in Poor Prognosis Neuroblastoma Patients. Lorena Passoni, Luca Longo, Paola Collini, Addolorata Maria Luce Coluccia, Fabio Bozzi, Endocrinology Marta Podda, Andrea Gregorio, Claudio Gambini, Alberto Garaventa, Vito Pistoia, Federica Del Grosso, Gian Paolo Tonini, Mangeng Cheng, Role of Cyclic AMP Response Element–Binding Protein in Carlo Gambacorti-Passerini, Andrea Anichini, Franca Fossati-Bellani, Insulin-like Growth Factor-I Receptor Up-regulation by Sex Massimo Di Nicola, and Roberto Luksch ...... 7338 Steroids in Prostate Cancer Cells. Marco Genua, Giuseppe Pandini, Diego Sisci, Gabriella Castoria, Marcello Maggiolini, Riccardo Vigneri, Pomalidomide and Lenalidomide Induce p21WA F- 1 Expression in and Antonino Belfiore ...... 7270 Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic Mechanism. Laure Escoubet-Lozach, I-Lin Lin, Inactivation of the Carney Complex Gene 1 (Protein Kinase A Kristen Jensen-Pergakes, Helen A. Brady, Anita K. Gandhi, Regulatory Subunit 1A) Inhibits SMAD3 Expression and Peter H. Schafer, George W. Muller, Peter J. Worland, TGF␤–Stimulated Apoptosis in Adrenocortical Cells. Kyle W.H. Chan, and Dominique Verhelle ...... 7347 Bruno Ragazzon, Laure Cazabat, Marthe Rizk-Rabin, Guillaume Assie, Lionel Groussin, Hélène Fierrard, Karine Perlemoine, Identification of Novel Gene Amplifications in Breast Cancer and Antoine Martinez, and Jérôme Bertherat ...... 7278 Coexistence of Gene Amplification with an Activating Mutation of PIK3CA. Mitsutaka Kadota, Misako Sato, Beverly Duncan, Akira Ooshima, Howard H. Yang, Natacha Diaz-Meyer, Sheryl Gere, Experimental Therapeutics, Molecular Targets, Shun-Ichiro Kageyama, Junya Fukuoka, Takuya Nagata, and Chemical Biology Kazuhiro Tsukada, Barbara K. Dunn, Lalage M. Wakefield, and Maxwell P. Lee ...... 7357 Essential Role of DNA Base Excision Repair on Survival in an Acidic Tumor Microenvironment. Yuji Seo and Timothy J. Kinsella ...... 7285 Dysfunctional Transforming Growth Factor-␤ Receptor II Accelerates Prostate Tumorigenesis in the TRAMP Mouse Model. Hong Pu, Joanne Collazo, Elisabeth Jones, Dustin Gayheart, Shinichi Sakamoto, Structural Basis for the Inhibition of Human Adam Vogt, Bonnie Mitchell, and Natasha Kyprianou ...... 7366 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues. Dong Wu, Yang Li, Gaojie Song, Chongyun Cheng, Rongguang Zhang, Andrzej Joachimiak, Down-regulation of Suppressor of Cytokine Signaling-3 Causes Neil Shaw, and Zhi-Jie Liu ...... 7294 Prostate Cancer Cell Death through Activation of the Extrinsic and Intrinsic Apoptosis Pathways. Martin Puhr, Frédéric R. Santer, 17-Hydroxy-jolkinolide B Inhibits Signal Transducers and Activators of Hannes Neuwirt, Martin Susani, Jeffrey A. Nemeth, Alfred Hobisch, Transcription 3 Signaling by Covalently Cross-Linking Janus Kinases Lukas Kenner, and Zoran Culig...... 7375 and Induces Apoptosis of Human Cancer Cells. Ying Wang, Xiuquan Ma, Shousheng Yan, Shensi Shen, Huiling Zhu, Yuan Gu, Hongbing Wang, Integrative Transcriptome Analysis Reveals Common Molecular Guowei Qin, and Qiang Yu ...... 7302 Subclasses of Human Hepatocellular Carcinoma. Yujin Hoshida, Sebastian M.B. Nijman, Masahiro Kobayashi, Jennifer A. Chan, Genetic Alterations in the Phosphoinositide 3-Kinase/Akt Signaling Jean-Philippe Brunet, Derek Y. Chiang, Augusto Villanueva, Pathway Confer Sensitivity of Thyroid Cancer Cells to Therapeutic Philippa Newell, Kenji Ikeda, Masaji Hashimoto, Goro Watanabe, Targeting of Akt and Mammalian Target of Rapamycin. Dingxie Liu, Stacey Gabriel, Scott L. Friedman, Hiromitsu Kumada, Peng Hou, Zhi Liu, Guojun Wu, and Mingzhao Xing...... 7311 Josep M. Llovet, and Todd R. Golub ...... 7385

Glomus Tumors in Neurofibromatosis Type 1: Genetic, Functional, Immunology and Clinical Evidence of a Novel Association. Hilde Brems, Caroline Park, Ophélia Maertens, Alexander Pemov, Ludwine Messiaen, Integrin ␣2 Mediates Selective Metastasis to the Liver. Meena Upadhyaya, Kathleen Claes, Eline Beert, Kristel Peeters, Kiyoshi Yoshimura, Kristen F. Meckel, Lindsay S. Laird, Christina Y. Chia, Victor Mautner, Jennifer L. Sloan, Lawrence Yao, Chyi-Chia Richard Lee, Jang-June Park, Kelly L. Olino, Ryouichi Tsunedomi, Toshio Harada, Raf Sciot, Luc De Smet, Eric Legius, and Douglas R. Stewart ...... 7393 Norio Iizuka, Shoichi Hazama, Yukihiko Kato, Jesse W. Keller, John M. Thompson, Fumin Chang, Lewis H. Romer, Ajay Jain, Christine Iacobuzio-Donahue, Masaaki Oka, Drew M. Pardoll, The Neuroendocrine-Derived Peptide Parathyroid and Richard D. Schulick ...... 7320 Hormone–Related Protein Promotes Prostate Cancer Cell Growth by Stabilizing the Androgen Receptor. John DaSilva, Daniel Gioeli, Michael J. Weber, and Sarah J. Parsons ...... 7402 In situ Stimulation of CD40 and Toll-like Receptor 3 Transforms Ovarian Cancer–Infiltrating Dendritic Cells from Immunosuppressive to Immunostimulatory Cells. Uciane K. Scarlett, DNMT1 and DNMT3B Modulate Distinct Polycomb-Mediated Juan R. Cubillos-Ruiz, Yolanda C. Nesbeth, Diana G. Martinez, Histone Modifications in Colon Cancer. Bilian Jin, Bing Yao, Xavier Engle, Andrew T. Gewirtz, Cory L. Ahonen, Jian-Liang Li, C. Robert Fields, Amber L. Delmas, Chen Liu, and Jose R. Conejo-Garcia ...... 7329 and Keith D. Robertson ...... 7412

Colorectal Cancer Risk Is Not Associated with Increased Levels of Homozygosity in a Population from the United Kingdom. Systems Biology and Emerging Technologies Sarah L. Spain, Jean-Baptiste Cazier, The CORGI Consortium, A Risk Variant in an miR-125b Binding Site in BMPR1B Is Associated Richard Houlston, Luis Carvajal-Carmona, and Ian Tomlinson...... 7422 with Breast Cancer Pathogenesis. Pål Sætrom, Jacob Biesinger, Sierra M. Li, David Smith, Laurent F. Thomas, Karim Majzoub, Guillermo E. Rivas, Jessica Alluin, John J. Rossi, Theodore G. Krontiris, The Receptor Tyrosine Kinase EPHB4 Has Tumor Suppressor Activities Jeffrey Weitzel, Mary B. Daly, Al B. Benson, John M. Kirkwood, in Intestinal Tumorigenesis. Higinio Dopeso, Silvia Mateo-Lozano, Peter J. O’Dwyer, Rebecca Sutphen, James A. Stewart, David Johnson, Rocco Mazzolini, Paulo Rodrigues, Laura Lagares-Tena, Julian Ceron, and Garrett P. Larson...... 7459 Jordi Romero, Marielle Esteves, Stefania Landolfi, Javier Hernández-Losa, Julio Castaño, Andrew J. Wilson, Santiago Ramon y Cajal, John M. Mariadason, Simo Schwartz Jr., and Diego Arango ...... 7430 Tumor Microenvironment

Inhibition of Tumor Growth Progression by Antiandrogens and mTOR Inhibitor in a Pten-Deficient Mouse Model of Prostate Cancer. Prevention Weisheng Zhang, Joe Zhu, Clay L. Efferson, Chris Ware, Jennifer Tammam, Minilik Angagaw, Jason Laskey, Kimberly A. Bettano, Shailaja Kasibhatla, Elevated Epithelial Insulin-like Growth Factor Expression Is a Risk John F. Reilly, Cyrille Sur, and Pradip K. Majumder ...... 7466 Factor for Lung Cancer Development. Woo-Young Kim, Quanri Jin, Seung-Hyun Oh, Edward S. Kim, Youn Joo Yang, Dong Hoon Lee, Parathyroid Hormone–Related Protein Protects against Mammary Lei Feng, Carmen Behrens, Ludmila Prudkin, York E. Miller, J. Jack Lee, Tumor Emergence and Is Associated with Monocyte Infiltration in Scott M. Lippman, Waun Ki Hong, Ignacio I. Wistuba, Ductal Carcinoma In situ. Nicholas I. Fleming, Melanie K. Trivett, and Ho-Young Lee ...... 7439 Joshy George, John L. Slavin, William K. Murray, Jane M. Moseley, Robin L. Anderson, and David M. Thomas ...... 7473

Resveratrol Suppresses Growth of Human Ovarian Cancer Cells in Letter to the Editor Culture and in a Murine Xenograft Model: Eukaryotic Elongation Factor 1A2 as a Potential Target. Mee-Hyun Lee, Bu Young Choi, Confounding Effects in “A Six-Gene Signature Predicting Joydeb Kumar Kundu, Young Kee Shin, Hye-Kyung Na, Breast Cancer Lung Metastasis”. Aedín C. Culhane and Young-Joon Surh ...... 7449 and John Quackenbush...... 7480

Cancer Res 2009;69:7131-7485.

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