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Cancer Research A JournalA Journal of ofthe the American American Association Association for for Cancer Cancer Research Research ISSN 0008-5472 (Print) ISSN 1538-7445 (Online) Volume 69 • Number 18 September 15, 2009 • Pages 7131–7486 Reviews Cell, Tumor, and Stem Cell Biology Development and Cancer: At the Crossroads of Nodal and Notch Insulin Receptor Substrate-1 Suppresses Transforming Growth Signaling. Luigi Strizzi, Katharine M. Hardy, Elisabeth A. Seftor, Factor-␤1–Mediated Epithelial-Mesenchymal Transition. Fabricio F. Costa, Dawn A. Kirschmann, Richard E.B. Seftor, Jian Shi, Dong-Mei Wang, Chun-Mei Wang, Ying Hu, Ai-Hua Liu, Lynne-Marie Postovit, and Mary J.C. Hendrix.............................................7131 Yong-Lian Zhang, Bing Sun, and Jian-Guo Song .........................................7180 Epithelial-Mesenchymal Transition and Cell Cooperativity in Mouse Mammary Tumor Virus p75 and p110 CUX1 Transgenic Metastasis. Takanori Tsuji, Soichiro Ibaragi, and Guo-fu Hu .............7135 Mice Develop Mammary Tumors of Various Histologic Types. Advances in Ewing’s Sarcoma Research: Where Are We Now and Chantal Cadieux, Valérie Kedinger, Lu Yao, Charles Vadnais, What Lies Ahead? José Luis Ordóñez, Daniel Osuna, David Herrero, Maria Drossos, Marilène Paquet, and Alain Nepveu.............................7188 Enrique de Álava, and Juan Madoz-Gúrpide .......................................7140 NEDD9 Promotes Oncogenic Signaling in Mammary Tumor Development. Eugene Izumchenko, Mahendra K. Singh, Perspectives in Cancer Research Olga V. Plotnikova, Nadezhda Tikhmyanova, Joy L. Little, Ilya G. Serebriiskii, Sachiko Seo, Mineo Kurokawa, Brian L. Egleston, Andres Klein-Szanto, Elena N. Pugacheva, Richard R. Hardy, Behavioral Oncology and the War on Cancer: Partnering with Marina Wolfson, Denise C. Connolly, and Erica A. Golemis..................7198 Biomedicine. Michael E. Stefanek, Michael A. Andrykowski, Caryn Lerman, Sharon Manne, and Karen Glanz on behalf of the AACR Behavioral Science Task Force..................................................7151 A Genetic Variant of Aurora Kinase A Promotes Genomic Instability Leading to Highly Malignant Skin Tumors. Enrique C. Torchia, Yiyun Chen, Hong Sheng, Hiroshi Katayama, James Fitzpatrick, William R. Brinkley, Carlos Caulin, Subrata Sen, and Dennis R. Roop......7207 Meeting Report Tumor Immunology: New Perspectives. Stephanie E. McArdle Epigenetic Loss of Mucosa-Associated Lymphoid Tissue 1 and Robert C. Rees ................................................................................7157 Expression in Patients with Oral Carcinomas. Tadashige Chiba, Genta Maeda, Shuichi Kawashiri, Koroku Kato, and Kazushi Imai ..............................................................................7216 Priority Reports Tuberous Sclerosis Complex Suppression in Cerebellar Development and Medulloblastoma: Separate Regulation of Mammalian Target mTOR Signal and Hypoxia-Inducible Factor-1␣ Regulate CD133 of Rapamycin Activity and p27Kip1 Localization. Bobby Bhatia, Expression in Cancer Cells. Kazuko Matsumoto, Tokuzo Arao, Paul A. Northcott, Dolores Hambardzumyan, Baskaran Govindarajan, Kaoru Tanaka, Hiroyasu Kaneda, Kanae Kudo, Yoshihiko Fujita, Daniel J. Brat, Jack L. Arbiser, Eric C. Holland, Michael D. Taylor, Daisuke Tamura, Keiichi Aomatsu, Tomohide Tamura, Yasuhide Yamada, and Anna Marie Kenney ...................................................................7224 Nagahiro Saijo, and Kazuto Nishio...............................................................7160 miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Mitochondrial Expression and Functional Activity of Breast Cancer Hormone-Dependent and Hormone-Independent Prostate Cancer Resistance Protein in Different Multiple Drug-Resistant Cell Lines. Growth. Judit Ribas, Xiaohua Ni, Michael Haffner, Erik A. Wentzel, Michela Solazzo, Ornella Fantappiè, Massimo D’Amico, Chiara Sassoli, Amirali Hassanzadeh Salmasi, Wasim H. Chowdhury, Alessia Tani, Greta Cipriani, Costanza Bogani, Lucia Formigli, Tarana A. Kudrolli, Srinivasan Yegnasubramanian, Jun Luo, and Roberto Mazzanti ..................................................................................7235 Ron Rodriguez, Joshua T. Mendell, and Shawn E. Lupold .....................7165 Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis Clear Differences in Levels of a Formaldehyde-DNA Adduct and Vasculogenesis via Vascular Endothelial Growth Factor and in Leukocytes of Smokers and Nonsmokers. Mingyao Wang, Stromal-Derived Factor 1. Chris Folkins, Yuval Shaked, Shan Man, Guang Cheng, Silvia Balbo, Steven G. Carmella, Peter W. Villalta, Terence Tang, Christina R. Lee, Zhenping Zhu, Robert M. Hoffman, and Stephen S. Hecht .............................................................................7170 and Robert S. Kerbel .....................................................................................7243 KDR Activating Mutations in Human Angiosarcomas Are Sensitive to Specific Kinase Inhibitors. Cristina R. Antonescu, Matrix Metalloproteinase 12 Overexpression in Lung Epithelial Akihiko Yoshida, Tianhuo Guo, Ning-En Chang, Lei Zhang, Cells Plays a Key Role in Emphysema to Lung Bronchioalveolar Narasimhan P. Agaram, Li-Xuan Qin, Murray F. Brennan, Adenocarcinoma Transition. Peng Qu, Hong Du, Xi Wang, Samuel Singer, and Robert G. Maki .......................................................7175 and Cong Yan .................................................................................................7252 Downloaded from cancerres.aacrjournals.org on October 1, 2021. © 2009 American Association for Cancer Research. Contents (Continued) Irradiation Alters Selection for Oncogenic Mutations in Hematopoietic Progenitors. Andriy Marusyk, Matias Casás-Selves, Molecular Biology, Pathobiology, and Genetics Curtis J. Henry, Vadym Zaberezhnyy, Jelena Klawitter, Uwe Christians, Mutation-Independent Anaplastic Lymphoma Kinase Overexpression and James DeGregori.....................................................................................7262 in Poor Prognosis Neuroblastoma Patients. Lorena Passoni, Luca Longo, Paola Collini, Addolorata Maria Luce Coluccia, Fabio Bozzi, Endocrinology Marta Podda, Andrea Gregorio, Claudio Gambini, Alberto Garaventa, Vito Pistoia, Federica Del Grosso, Gian Paolo Tonini, Mangeng Cheng, Role of Cyclic AMP Response Element–Binding Protein in Carlo Gambacorti-Passerini, Andrea Anichini, Franca Fossati-Bellani, Insulin-like Growth Factor-I Receptor Up-regulation by Sex Massimo Di Nicola, and Roberto Luksch ...............................................7338 Steroids in Prostate Cancer Cells. Marco Genua, Giuseppe Pandini, Diego Sisci, Gabriella Castoria, Marcello Maggiolini, Riccardo Vigneri, Pomalidomide and Lenalidomide Induce p21WA F- 1 Expression in and Antonino Belfiore ............................................................................7270 Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic Mechanism. Laure Escoubet-Lozach, I-Lin Lin, Inactivation of the Carney Complex Gene 1 (Protein Kinase A Kristen Jensen-Pergakes, Helen A. Brady, Anita K. Gandhi, Regulatory Subunit 1A) Inhibits SMAD3 Expression and Peter H. Schafer, George W. Muller, Peter J. Worland, TGF␤–Stimulated Apoptosis in Adrenocortical Cells. Kyle W.H. Chan, and Dominique Verhelle ..............................................7347 Bruno Ragazzon, Laure Cazabat, Marthe Rizk-Rabin, Guillaume Assie, Lionel Groussin, Hélène Fierrard, Karine Perlemoine, Identification of Novel Gene Amplifications in Breast Cancer and Antoine Martinez, and Jérôme Bertherat ...........................................7278 Coexistence of Gene Amplification with an Activating Mutation of PIK3CA. Mitsutaka Kadota, Misako Sato, Beverly Duncan, Akira Ooshima, Howard H. Yang, Natacha Diaz-Meyer, Sheryl Gere, Experimental Therapeutics, Molecular Targets, Shun-Ichiro Kageyama, Junya Fukuoka, Takuya Nagata, and Chemical Biology Kazuhiro Tsukada, Barbara K. Dunn, Lalage M. Wakefield, and Maxwell P. Lee ......................................................................................7357 Essential Role of DNA Base Excision Repair on Survival in an Acidic Tumor Microenvironment. Yuji Seo and Timothy J. Kinsella ...............................................................................7285 Dysfunctional Transforming Growth Factor-␤ Receptor II Accelerates Prostate Tumorigenesis in the TRAMP Mouse Model. Hong Pu, Joanne Collazo, Elisabeth Jones, Dustin Gayheart, Shinichi Sakamoto, Structural Basis for the Inhibition of Human Adam Vogt, Bonnie Mitchell, and Natasha Kyprianou ..........................7366 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues. Dong Wu, Yang Li, Gaojie Song, Chongyun Cheng, Rongguang Zhang, Andrzej Joachimiak, Down-regulation of Suppressor of Cytokine Signaling-3 Causes Neil Shaw, and Zhi-Jie Liu .......................................................................7294 Prostate Cancer Cell Death through Activation of the Extrinsic and Intrinsic Apoptosis Pathways. Martin Puhr, Frédéric R. Santer, 17-Hydroxy-jolkinolide B Inhibits Signal Transducers and Activators of Hannes Neuwirt, Martin Susani, Jeffrey A. Nemeth, Alfred Hobisch, Transcription 3 Signaling by Covalently Cross-Linking Janus Kinases Lukas Kenner, and Zoran Culig.................................................................7375 and Induces Apoptosis of Human Cancer Cells. Ying Wang, Xiuquan Ma, Shousheng Yan, Shensi Shen, Huiling Zhu, Yuan Gu,
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  • Bmpr1a and Bmpr1b Have Overlapping Functions and Are Essential for Chondrogenesis in Vivo

    Bmpr1a and Bmpr1b Have Overlapping Functions and Are Essential for Chondrogenesis in Vivo

    Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo Byeong S. Yoon*, Dmitry A. Ovchinnikov†, Isaac Yoshii*, Yuji Mishina‡, Richard R. Behringer†, and Karen M. Lyons*§¶ʈ Departments of *Molecular, Cell, and Developmental Biology, §Orthopaedic Surgery, and ¶Biological Chemistry, University of California, Los Angeles, CA 90095; †Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030; and ‡Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 Edited by Kathryn V. Anderson, Sloan–Kettering Institute, New York, NY, and approved February 24, 2005 (received for review January 3, 2005) Previous studies have demonstrated the ability of bone morpho- functions or a more prominent role for BMPR1A during chon- genetic proteins (BMPs) to promote chondrogenic differentiation drogenesis in mice (9, 10). in vitro. However, the in vivo role of BMP signaling during chon- We generated mice that are null for both Bmpr1a and Bmpr1b drogenesis has been unclear. We report here that BMP signaling is in chondrocytes to examine the possibility of functional redun- essential for multiple aspects of early chondrogenesis. Whereas dancy and͞or unique functions for Bmpr1a and Bmpr1b and to mice deficient in type 1 receptors Bmpr1a or Bmpr1b in cartilage are clarify the role of BMPs during chondrogenesis. We show that able to form intact cartilaginous elements, double mutants develop like Bmpr1b null mice, Bmpr1a conditional knockouts (CKOs) CKO Ϫ/Ϫ a severe generalized chondrodysplasia. The majority of skeletal have few skeletal defects. However, Bmpr1a ; Bmpr1b elements that form through endochondral ossification are absent, mice develop a severe and generalized chondrodysplasia, dem- and the ones that form are rudimentary.
  • CD System of Surface Molecules

    CD System of Surface Molecules

    THE CD SYSTEM OF LEUKOCYTE APPENDIX 4A SURFACE MOLECULES Monoclonal Antibodies to Human Cell Surface Antigens APPENDIX 4A Alice Beare,1 Hannes Stockinger,2 Heddy Zola,1 and Ian Nicholson1 1Women’s and Children’s Health Research Institute, Women’s and Children’s Hospital, Adelaide, Australia 2Institute of Immunology, University of Vienna, Vienna ABSTRACT Many of the leukocyte cell surface molecules are known by “CD” numbers. In this Appendix, a short introduction describes the history and the use of CD nomenclature and provides a few key references to enable access to the wider literature. This is followed by a table that lists all human molecules with approved CD names, tabulating alternative names, key structural features, cellular expression, major known functions, and usefulness of the molecules or antibodies against them in research or clinical applications. Curr. Protoc. Immunol. 80:A.4A.1-A.4A.73. C 2008 by John Wiley & Sons, Inc. Keywords: CD nomenclature r HLDA r HCDM r leukocyte marker r human leukocyte differentiation r antigens INTRODUCTION During the last 25 years, large numbers of monoclonal antibodies (MAbs) have been pro- duced that have facilitated the purification and functional characterization of a plethora of leukocyte surface molecules. The antibodies have been even more useful as markers for cell populations, allowing the counting, separation, and functional study of numer- ous subsets of cells of the immune system. A series of international workshops were instrumental in coordinating this development through multi-laboratory “blind” studies of thousands of antibodies. These HLDA (Human Leukocyte Differentiation Antigens) Workshops have, up until now, defined 500 different entities and assigned them cluster of differentiation (CD) designations.