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A Visual Analysis Tool for Medication Use Data in the ABCD Study

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A Visual Analysis Tool for Medication Use Data in the ABCD Study Eurographics Workshop on Visual Computing for Biology and Medicine (2019) Short Paper K. Lawonn and R. G. Raidou (Editors) MedUse: A Visual Analysis Tool for Medication Use Data in the ABCD Study H. Bartsch1,2 and L. Garrison5 and S. Bruckner5 and A. (Szu-Yung) Wang4 and S. F. Tapert3 and R. Grüner1 1Mohn Medical Imaging and Visualization Centre, Haukeland University Hospital, Bergen, Norway 2Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, United States 3Department of Psychiatry, University of California San Diego, La Jolla, California, United States 4Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, United States 5Department of Informatics, University of Bergen, Norway 58930 Zyrtec #209 1186679 Zyrtec Pill #29 865258 Aller Tec #18 203150 cetirizine hydrochloride #15 1186677 Zyrtec Oral Liquid Product #6 1152447 Cetirizine Pill #5 1086791 Wal Zyr #5 1366498 Ahist Antihistamine Oral Product #4 1428980 Cetirizine Oral Solution [Pediacare Children's 24 Hr Allergy] #3 1020026 cetirizine hydrochloride 10 MG Oral Tablet [Zyrtec] #3 1020023 cetirizine hydrochloride 10 MG Oral Capsule [Zyrtec] #3 371364 Cetirizine Oral Tablet #3 1366499 Ahist Antihistamine Pill #2 1296197 Zyrtec Disintegrating Oral Product #2 R06AE Piperazine derivatives #209 1186680 Zyrtec D Oral Product #2 1020021 cetirizine hydrochloride 1 MG/ML Oral Solution [Zyrtec] #2 759919 levocetirizine Oral Solution #2 398335 Xyzal #2 1595661 1595661 #1 ine] #1 1296338 Zyrtec Chewable Product #1 1187910 Wal Zyr Pill #1 1186678 Zyrtec Oral Product #1 1186638 Xyzal Pill #1 1020025 cetirizine hydrochloride 10 MG Oral Tablet [Alleroff] #1 1020016 cetirizine hydrochloride 1 MG/ML [Aller Tec] #1 1011483 cetirizine hydrochloride 10 MG [Zyrtec] #1 855168 levocetirizine dihydrochloride 0.5 MG/ML Oral Solution #1 371362 Cetirizine Oral Solution #1 353102 Zyrtec D #1 1694 Bonine #1 203576 Claritin #133 324026 Allegra #37 316167 Loratadine 10 MG #15 1171569 Claritin Pill #9 1369748 Allerclear #8 1297046 Claritin Chewable Product #6 707591 Alaway #6 1166659 Allegra Oral Liquid Product #4 1296601 Claritin Disintegrating Oral Product #3 R06 ANTIHISTAMINES FOR SYSTEMIC USE #209 R06A ANTIHISTAMINES FOR SYSTEMIC USE #209 1296571 Alavert Disintegrating Oral Product #3 1171571 Claritin D Pill #3 352401 Alavert #3 316168 Loratadine 5 MG #3 261705 Zaditor #3 1186869 Zaditor Ophthalmic Product #2 R06AX Other antihistamines for systemic use #133 1173504 Alavert D Pill #2 1171570 Claritin D Oral Product #2 1166661 Allegra Pill #2 1151461 Cyproheptadine Pill #2 836338 Loratadine 10 MG Oral Capsule [Claritin] #2 744830 Loratadine 10 MG Disintegrating Oral Tablet [Claritin] #2 1488053 Fexofenadine hydrochloride 180 MG Oral Tablet [Mucinex Non Drowsy Allergy] #1 1369752 Allerclear Pill #1 1171568 Claritin Oral Product #1 1171567 Claritin Oral Liquid Product #1 1171562 Clarinex D Pill #1 1165337 Loratadine Pill #1 1090510 Loratadine 10 MG [Wal vert] #1 1020126 Loratadine 10 MG Oral Tablet [Loradamed] #1 1020125 Loratadine Oral Tablet [Loradamed] #1 1020124 Loratadine 10 MG [Loradamed] #1 311372 Loratadine 10 MG Oral Tablet #1 216076 Claritin D #1 796199 Dimetapp Cold #8 R06AB Substituted alkylamines #8 353035 Triaminic Cold and Allergy #2 1294014 Brompheniramine Maleate 2 MG #1 1090458 1090458 #1 202384 Chlor Trimeton #1 153889 Singulair #46 1296363 Singulair Chewable Product #16 R03DC Leukotriene receptor antagonists #46 330047 montelukast 5 MG #13 115713 montelukast sodium #10 1183694 Singulair Pill #7 MedUse: Medication use analysis forR03D the OTHER SYSTEMIC DRUGSlargest FOR OBSTRUCTIVE AIRWAY DISEASES #46 long-term study of brain development and child health in the United States. Figure 1: 1157312 montelukast Pill #2 153892 montelukast 10 MG Oral Tablet [Singulair] #1 R03DX Other systemic drugs for obstructive airway diseases #1 356767 356767 #1 647295 ProAir #32 1649960 ProAir Inhalant Product #14 8887 Ventolin #13 R RESPIRATORY SYSTEM #209 142153 Albuterol Sulfate #10 1187868 Ventolin Inhalant Product #9 745752 200 ACTUAT Albuterol 0.09 MG/ACTUAT Metered Dose Inhaler [ProAir] #7 R03AC Selective beta 2 adrenoreceptor agonists #32 202908 Proventil #4 R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES #46 1008406 Albuterol / Ambroxol #2 346188 Albuterol 0.83 MG/ML #2 1182471 Proventil Inhalant Product #1 1154606 Albuterol Pill #1 ] #1 Abstract R03A ADRENERGICS, INHALANTS #32 801094 Albuterol Metered Dose Inhaler [Ventolin] #1 330935 Albuterol 0.5 MG/ML #1 10369 10369 #1 50121 Fluticasone propionate #24 301543 Advair #17 The RxNorm vocabulary is a yearly-published biomedical resourceR03AK Adrenergics in combination providing with corticosteroids or other drugs, excl. anticholinergics #24 normalized names for medications. It is used 1372704 Dulera #5 30145 mometasone furoate #5 R03C ADRENERGICS FOR SYSTEMIC USE #0 1171309 Advair Inhalant Product #3 R03CC Selective beta 2 adrenoreceptor agonists #0 MG/ACTUAT Dry Powder Inhaler [Advair] #2 R05C EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS #23 R05CA Expectorants #23 to capture medication use in the Adolescent Brain Cognitive Development (ABCD) study, an active and352777 Mucinex #23 publicly available 1171649 Cough Out Oral Liquid Product #1 702274 Nyquil Cough #16 R05 COUGH AND COLD PREPARATIONS #23 1114038 DayQuil Cough #8 3146 Delsym #8 longitudinal research study following 11,800 children over 10 years. In this work, we present medUse, a353037 Triaminic visual Cough #4 tool allowing 672676 Mucinex Cough #3 R05DA Opium alkaloids and derivatives #16 702442 Zicam Cough #2 R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS #16 l Solution [Delsym Cough Plus Chest Congestion DM] #1 R05DB Other cough suppressants #0 1297101 Delsym Oral Liquid Product #1 researchers to explore and analyze the relationship of drug category to cognitive or imaging derived measures1183325 Mucinex DM Pill #1 using ABCD 1179871 Nyquil Cough Oral Liquid Product #1 727556 Dextromethorphan 5 MG / Guaifenesin 100 MG Oral Granules [Mucinex Children's Cough] #1 692906 Triaminic Day Time Cold & Cough #1 236146 dextromethorphan polistirex #1 study data. Our tool provides position-based contextR01B NASAL DECONGESTANTS FOR SYSTEMIC for USE #8 tree traversal and selectionR01BA Sympathomimetics #8 granularity of both study203302 Sudafed #8 participants and 1180816 Sudafed Oral Liquid Product #1 643092 Wal Phed #1 drug category. Developed as part of the Data Exploration and Analysis Portal (DEAP), medUse is available215051 Afrin #4 to more than 600 ABCD researchers world-wide. By integrating medUse into an actively used research product we are able to reach a wide audience and increase the practical relevance of visualization for the biomedical field. CCS Concepts • Human-centered computing Information visualization; Activity centered design; ! 1. Introduction store, merge, and filter the available project's data. All of these data management steps incur costs for the data sharing platform and the The evolution of data sharing platforms into data analysis sys- individual researcher, which can hinder biomedical research. Data tems is driven by the complexity of the analysis required to gen- sharing platforms such as the NIMH Data Archive [Nata] there- erate publishable results, the complexity of the data shared, and fore add features for online data analysis such as the Data Analysis the costs involved in downloading and post-processing data. Us- and Exploration Portal (DEAP) [DEA]. This provides a unique op- ing conventional methods to access the data generated with obser- portunity for visualization to impact ongoing research in the fields vational studies such as the Adolescent Brain Cognitive Develop- of developmental science and neuropsychology. The DEAP sys- tem provides access to ABCD study data to individual researchers ment (ABCD) study [CCC⇤18], a researcher needs to download, © 2019 The Author(s) Eurographics Proceedings © 2019 The Eurographics Association. DOI: 10.2312/vcbm.20191236 https://www.eg.org https://diglib.eg.org 98 H. Bartsch, L. Garrison, S. Bruckner, A. Wang, S.F. Tapert & R. Grüner / medUse ATC level L1 L2 L3 L4 RxNorm spiral arrangements [Sch11, Cui] with the goal to produce visually pleasing graphical representations. Space filling visualizations such as treemaps [Shn92] are more space conserving compared to many node-linked methods. They are well suited for displaying information located at the leaf nodes of the hierarchy [GBP02], but they are more difficult to use for the task of selecting non-leaf nodes in large trees. Selection and nav- igation between neighboring nodes in the tree can result in focus movements in both horizontal and vertical planes with distance as the conserved organizational principle. Treemaps can be adjusted to allow for parent labels to be displayed [LMS⇤18,KH14] but exam- ples presented in those implementations suggest that they are more tailored for short labels. Support for a focused display of labels at different scales has been suggested [KvK⇤19]. Using camera dis- tance and occlusion to selectively show and position hierarchical labels of multi-instance objects for volumetric displays. Focus and context approaches have been suggested to help users to show particular tree nodes while providing context for the place- ment of the node in the hierarchy [LRP95, SCF11]. The 2D dis- ATC classified medications classified ATC tortion introduced to highlight a focus point in the graph can be severe and require global changes in the visual
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