Program at a Glance
Saturday Sunday Monday Tuesday Wednesday
March 29, 2014 March 30, 2014 March 31, 2014 April 1, 2014 April 2, 2014
07:00 Breakfast and Breakfast and - Breakfast Breakfast 08:30 poster mounting poster mounting
Oral session XI: Oral session II: Oral session 08:30 Intracellular - Serpins in VII: Serpins in functions of 10:00 cancer neurobiology serpins
10:00 Coffee break - and poster Coffee break Coffee break “Meet the 10:30 viewing experts” or free time Oral session III: Oral Session Oral session 10:30 Serpins in VIII: Non- XII: New - inflammation and 12:00 mammalian functions of tissue serpins serpins II remodeling 12:00 Closing remarks - Lunch Lunch Lunch and 13:30 Departure
Oral session IX: Serpin-related Oral session V: diseases: Serpin 13:30 cellular injury, - conformation, disease 15:30 maturation, modifiers, and and/or disposal therapeutic Free time approaches
Registration 15:30 Coffee break - and poster Coffee break 16:00 viewing 16:00 Best abstract Best abstract - award lectures award lectures 16:30 1 2 Oral session X : Oral session IV: Oral session VI: 16:30 Serpins and - New functions of Evolution of signal 17:30 serpins I serpins transduction 17:30 Welcome and - 18:00 Oral session I: Serpins in 18:00 leucocyte - biology 18:30 Dinner Dinner 19:00 - 19:30 Welcome Congress Reception Dinner 19:30 and Dinner Poster session Poster session - 23:00 1 2
8 Specific program March 29 ththth , 2014
Saturday, March 29 th , 2014
17:30-17:45 Welcome
Oral session I: Serpins in leucocyte biology Chairperson: Alireza R. Rezaie (USA)
O1.01 17:45-18:15 Regulation of neutrophil survival by serpinB1 Charaf Benarafa (Theodor Kocher Institute, Bern Switzerland)
O1.02 18:15-18:30 Systemic inflammation induced by cigarette smoke exposure transiently increases myelopoiesis and lung bacterial clearance in serpinB1-/- mice Paola Basilico (University of Bern, Switzerland)
19:00 Welcome reception and dinner
9 Specific program March 30 ththth , 2014
Sunday, March 30 th , 2014
7:00-8:30 Breakfast and poster mounting
Oral session II: Serpins in cancer Chairpersons: Phil Bird (Australia) and Douglas Vaughan (USA)
O2.01 8:30-9:00 Maspin is a multi-functional tumor suppressing serpin Ming Zhang (Northwestern University, Chicago, Il, USA )
O2.02 9:00-9:15 Tumor cell-expressed serpinB2 is present on microparticles and inhibits metastasis Andreas Suhrbier (Queensland Institute of medical Research, Brisbane, Australia)
O2.03 9:15-9:30 Myxomaviral serpin Serp-1 inhibits pancreatic cancer growth in mice Alexandra Lucas (University of Florida, Gainesville, USA)
O2.04 9:30-10:00 The maspin enigma Phil Bird (Monash University, Victoria, Australia )
10:00-10:30 Coffee break and poster viewing
Oral session III: Serpins in inflammation and tissue remodeling Chairpersons: Robin Carrell (United Kingdom) and Jean-Marc Reichhart (France)
O3.01 10:30-11:00 Protease nexin-1 in tissue remodelling Marie-Christine Bouton (Unite Inserm U1148 - LVTS, Paris, France)
O3.02 11:00-11:15 Caspase 1 deficiency and viral anti-inflammatory protein Serp-2 improves survival in liver ischemia/reperfusion injury mouse models Hao Chen (University of Florida, Gainesville, USA)
10 Specific program March 30 ththth , 2014
O3.03 11:15-11:45 SerpinB1 regulates differentiation and expansion of IL17+ T cells Eileen Remold-O’Donnell (Harvard Medical School, Boston, MA, USA)
O3.04 11:45-12:15 Identification of the target protease of vaspin, a serpin derived from visceral adipose tissue Annette Beck-Sickinger (University of Leipzig, Germany)
12:15-13:30 Lunch
13:30-16:30 Free time
Oral session IV: New functions of serpins I Chairpersons: Alexandra Lucas (USA) and Thomas H. Roberts (Australia)
O4.01 16:30-16:45 Miropin, a serpin from a major periodontopathogen Tannerella forsythia inhibits both endogenous and human neutrophil serine proteases Miroslaw Ksi ąż ek (Jagiellonian University, Krakow, Poland and University of Louisville, Louisville, KY, USA)
O4.02 16:45-17:00 Structure-Function-Relationships in Hsp47 Ulrich Baumann (Cologne University, Germany)
O4.03 17:00-17:30 Identifying protease targets of the Drosophila serine protease inhibitor Serpin42Da James Whisstock (Monash University, Melbourne, Australia)
18:00-19:30 Dinner
Poster session 1
19:30 Poster discussion with the authors
11 Specific program March 31 ststst , 2014
Monday, March 31 st , 2014
7:00-8:30 Breakfast and poster mounting
8:30-13:30 “Meet the experts” or free time
Oral session V: Serpin conformation, maturation, and/or disposal Chairpersons: Elena Miranda (Italy) and Jim Huntington (UK)
O5.01 13:30-14:00 Structural understanding of angiotensinogen:renin interaction Randy Read (University of Cambridge, UK)
O5.02 14:00-14:30 SERPIN biosynthetic quality control involves both basal and anticipatory elements Richard N. Sifers (Baylor College of Medicine, Houston, USA)
O5.03 14:30-14:45 The PAI-1 latency transition at atomic resolution Pietro Faccioli (University of Trento, Italy)
O5.04 14:45-15:15 Characterization of the dynamic structure of PAI-1 using hydrogen/deuterium-exchange mass spectrometry Thomas J.D. Jørgensen (University of Southern Denmark, Denmark)
O5.05 15:15-15:30 Structure-based kinetic analysis of the reaction between plasminogen activator inhibitor-1 and urokinase and tissue-type plasminogen activators Jeppe Buur Madsen (Aarhus University, Denmark)
15:30-16:00 Coffee break
12 Specific program March 31 ststst , 2014
Best abstract award lectures 1 Chairpersons: Robert Fluhr (Israel) and Felix Wahlmüller (Austria)
A1.01 16:00-16:15 Heparin binding and vaspin/serpinA12 activity David Ulbricht (University of Leipzig, Germany)
A1.02 16:15-16:30 The shape of Z-α1-antitrypsin polymers in solution, support the mechanism of self-terminating polymer growth M.A. Behrens (Aarhus University, Denmark)
Oral session VI: Evolution of serpins Chairpersons: Robert Fluhr (Israel) and Felix Wahlmüller (Austria)
O6.01 16:30-17:00 Tracing the roots of coagulation control and blood pressure regulation by serpins Hermann Ragg (Bielefeld University, Germany)
O6.02 17:00-17:15 Natural and artificial selection in hexaploid bread wheat has produced a complex set of differentially expressed active and inactive serpin genes: implications for function Thomas H. Roberts (Macquarie University, Australia)
O6.03 17:15-17:30 Co-evolution of a serpin, its target serine protease, and protease substrate Agneszka Jendroszek (Aarhus University, Denmark)
18:00-19:30 Dinner
Poster session 2
19:30 Poster discussion with the authors
13 Specific program April 1 ststst , 2014
Tuesday, April 1 st , 2014
7:00-8:30 Breakfast
Oral session VII: Serpins in neurobiology Chairpersons: Marie-Christine Bouton (France) and Paul Declerck (Belgium)
O7.01 8:30-9:00 The tPA-serpins axis is a key regulator of neuronal fate Denis Vivien (Inserm U919, Caen, France)
O7.02 9:00-9:15 Neuroserpin polymer toxicity in a neuronal model of FENIB Claudia Moriconi (Sapienza University of Rome, Italy)
O7.03 9:15-9:30 Tissue Plasminogen Activator (tPA) modulates ischaemia- induced endoplasmic reticulum (ER) stress in cultured neurons Benoit Roussel (Inserm U919, Caen, France)
O7.04 9:30-10:00 Lipase involvement in the retina-protective effects of PEDF S. Patricia Becerra (National Eye Institute, NIH, Bethesda, USA)
10:00-10:30 Coffee break
Oral Session VIII: Non-mammalian serpins Chairpersons: Jan Potempa (USA) and James Whisstock (Australia)
O8.01 10:30-11:00 Serpins control programmed cell death during abiotic and biotic stress Robert Fluhr (Weizmann Institute of Science, Rehovot, Israel)
14 Specific program April 1 ststst , 2014
O8.02 11:00-11:30 Drosophila serpins in immunity and development Jean-Marc Reichhart (Université de Strasbourg, France)
O8.03 11:30-12:00 Serpins as Therapy – from Virus to Man Alexandra Lucas (University of Florida, Gainesville, USA)
12:00-13:30 Lunch
Oral session IX: Serpin-related diseases: cellular injury, disease modifiers, and therapeutic approaches Chairpersons: Cliff J. Luke (USA) and Richard N. Sifers (USA)
O9.01 13:30-14:00 How and why the Z-variant of alpha-1-antitrypsin polymerizes, and what can be done about it James A. Huntington ( University of Cambridge, UK)
O9.02 14:00-14:15 Modeling rare alpha-1 antitrypsin variants in C. elegans Erin Cummings (University of Pittsburgh Medical School, USA)
O9.03 14:15-14:30 A genome-wide high-content RNAi screen, using a C.elegans model of ATD, identifies genetic modifiers and drug targets Linda P. O'Reilly (University of Pittsburgh Medical School, USA)
O9.04 14:30-14:45 A single-chain variable fragment antibody against Z alpha1-antitrypsin prevents intracellular polymerization Elena Miranda (Sapienza University of Rome, Italy)
O9.05 14:45-15:00 The P1 residue determines the fate of ZPI-protease complex Aiwu Zhou (Shanghai Jiao Tong University School of Medicine, China)
15 Specific program April 1 ststst , 2014
O9.06 15:00-15:15 Protease exosites regulate heparin-catalyzed factor XIa inactivation by antithrombin Ingrid M. Verhamme (Vanderbbilt University School of Medicine, Nashville, TN, USA)
O9.07 15:15-15:30 Mutations creating new glycosylation sites cause different types of antithrombin deficiency. Role of an N-glycan at the reactive centre loop Sonia Aguila , (University of Murcia, Spain)
15:30-16:00 Coffee break
Best abstract award lectures 2 Chairpersons: Charaf Benarafa (Switzerland) and Chris Overall (Canada)
A2.01 16:00-16:15 A fluorescent probe study of protein Z dependent protease inhibitor (ZPI) interaction with protein Z Xin Huang (University of Illinois at Chicago, Chicago, USA)
A2.02 16:15-16:30 The structural study of angiotensinogen and the release of angiotensin Yahui Yan (University of Cambridge, UK)
Oral session X: Serpins and signal transduction Chairpersons: Charaf Benarafa (Switzerland) and Chris Overall (Canada)
O10.01 16:30-16:45 Pervasive interactions of proteases and their inhibitors form protein networks as part of a global protease web Nikolaus Fortelny (University of British Columbia, Vancouver, Canada)
O10.02 16:45-17:00 PAI-1 affects cellular migration and proliferation via LRP1 and uPAR Thomas Kietzmann (University of Oulu, Finland)
16 Specific program April 1 ststst , 2014
O10.03 17:00-17:15 Grafting D-helix of antithrombin to alpha-1-proteinase inhibitor confers antiinflammatory and cytoprotective signaling properties for the chimeric serpin Alireza R. Rezaie (Saint Louis University, USA)
O10.04 17:15-17:30 A mouse model transgenic for liver serpinB3 presents a hyperdynamic circulatory syndrome Andrea Martini (University of Padua, Italy )
19:00 Congress Dinner
17 Specific program April 2 ndndnd 2014
Wednesday, April 2 nd , 2014
7:00-8:30 Breakfast
Oral session XI: Intracellular functions of serpins Chairpersons: Peter Andreasen (Denmark) and Annette Beck-Sickinger (Germany)
O11.01 8:30-9:00 SerpinB2/PAI-2 roles in inflammatory responses Toni Antalis (University of Maryland, Baltimore, USA)
O11.02 9:00-9:15 Serpins in proteostasis: novel biological roles of the intracellular cysteine protease inhibitory serpin, SRP-6, in C. elegans Cliff J. Luke (University of Pittsburgh School of Medicine, Pittsburgh, PA, USA)
O11.03 9:15-9:30 Cytoprotective regulation of neutrophil serine proteases by MNEI (serpinB1) and PI-6 (serpinB6) in lung epithelial cells Sabrina Sofia Burgener (University of Bern, Switzerland)
O11.04 9:30-9:45 The role of cysteine protease inhibitory serpins in cytoprotection from regulated necrotic cell death in mammalian cells Cliff J. Luke (University of Pittsburgh School of Medicine, Pittsburgh, PA, USA)
O11.05 9:45-10:00 SerpinA5 is internalized by Jurkat lymphoma cells and regulates nuclear cathepsin L Margareta Furtmüller (Medical University of Vienna, Austria)
10:00-10:30 Coffee break
18 Specific program April 2 ndndnd ,,, 2014
Oral session XII: New functions of serpins II Chairpersons: Randy Read (UK) and Aiwu Zhou (P.R. China)
O12.01 10:30-11:00 PAI-1 is a critical mediator of senescence in vivo Douglas Vaughan (Northwestern University, Chicago, IL, USA)
O12.02 11:00-11:15 Towards engineering corticosteroid binding globulin as a drug delivery agent Wee Lee Chan , (University of Cambridge, UK)
O12.03 11:15-11:30 On the mechanism of the complex formation between α1-antitrypsin and fibrinogen Dick C. Rijken (Erasmus University Medical Center, Rotterdam, The Netherlands)
O12.04 11:30-12:00 Unexpected encounters with metalloproteinases: system- wide analysis of proteolysis in vivo uncovers the metallic serpin switch Christopher M. Overall (University of British Columbia, Vancouver, Canada)
12:00-12:10 Closing remarks
12:10-13:30 Lunch and departure
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