Program at a Glance Saturday Sunday Monday Tuesday Wednesday March 29, 2014 March 30, 2014 March 31, 2014 April 1, 2014 April 2, 2014 07:00 Breakfast and Breakfast and - Breakfast Breakfast 08:30 poster mounting poster mounting Oral session XI: Oral session II: Oral session 08:30 Intracellular - Serpins in VII: Serpins in functions of 10:00 cancer neurobiology serpins 10:00 Coffee break - and poster Coffee break Coffee break “Meet the 10:30 viewing experts” or free time Oral session III: Oral Session Oral session 10:30 Serpins in VIII: Non- XII: New - inflammation and 12:00 mammalian functions of tissue serpins serpins II remodeling 12:00 Closing remarks - Lunch Lunch Lunch and 13:30 Departure Oral session IX: Serpin-related Oral session V: diseases: Serpin 13:30 cellular injury, - conformation, disease 15:30 maturation, modifiers, and and/or disposal therapeutic Free time approaches Registration 15:30 Coffee break - and poster Coffee break 16:00 viewing 16:00 Best abstract Best abstract - award lectures award lectures 16:30 1 2 Oral session X : Oral session IV: Oral session VI: 16:30 Serpins and - New functions of Evolution of signal 17:30 serpins I serpins transduction 17:30 Welcome and - 18:00 Oral session I: Serpins in 18:00 leucocyte - biology 18:30 Dinner Dinner 19:00 - 19:30 Welcome Congress Reception Dinner 19:30 and Dinner Poster session Poster session - 23:00 1 2 8 Specific program March 29 ththth , 2014 Saturday, March 29 th , 2014 17:30-17:45 Welcome Oral session I: Serpins in leucocyte biology Chairperson: Alireza R. Rezaie (USA) O1.01 17:45-18:15 Regulation of neutrophil survival by serpinB1 Charaf Benarafa (Theodor Kocher Institute, Bern Switzerland) O1.02 18:15-18:30 Systemic inflammation induced by cigarette smoke exposure transiently increases myelopoiesis and lung bacterial clearance in serpinB1-/- mice Paola Basilico (University of Bern, Switzerland) 19:00 Welcome reception and dinner 9 Specific program March 30 ththth , 2014 Sunday, March 30 th , 2014 7:00-8:30 Breakfast and poster mounting Oral session II: Serpins in cancer Chairpersons: Phil Bird (Australia) and Douglas Vaughan (USA) O2.01 8:30-9:00 Maspin is a multi-functional tumor suppressing serpin Ming Zhang (Northwestern University, Chicago, Il, USA ) O2.02 9:00-9:15 Tumor cell-expressed serpinB2 is present on microparticles and inhibits metastasis Andreas Suhrbier (Queensland Institute of medical Research, Brisbane, Australia) O2.03 9:15-9:30 Myxomaviral serpin Serp-1 inhibits pancreatic cancer growth in mice Alexandra Lucas (University of Florida, Gainesville, USA) O2.04 9:30-10:00 The maspin enigma Phil Bird (Monash University, Victoria, Australia ) 10:00-10:30 Coffee break and poster viewing Oral session III: Serpins in inflammation and tissue remodeling Chairpersons: Robin Carrell (United Kingdom) and Jean-Marc Reichhart (France) O3.01 10:30-11:00 Protease nexin-1 in tissue remodelling Marie-Christine Bouton (Unite Inserm U1148 - LVTS, Paris, France) O3.02 11:00-11:15 Caspase 1 deficiency and viral anti-inflammatory protein Serp-2 improves survival in liver ischemia/reperfusion injury mouse models Hao Chen (University of Florida, Gainesville, USA) 10 ththth Specific program March 30 , 2014 O3.03 11:15-11:45 SerpinB1 regulates differentiation and expansion of IL17+ T cells Eileen Remold-O’Donnell (Harvard Medical School, Boston, MA, USA) O3.04 11:45-12:15 Identification of the target protease of vaspin, a serpin derived from visceral adipose tissue Annette Beck-Sickinger (University of Leipzig, Germany) 12:15-13:30 Lunch 13:30-16:30 Free time Oral session IV: New functions of serpins I Chairpersons: Alexandra Lucas (USA) and Thomas H. Roberts (Australia) O4.01 16:30-16:45 Miropin, a serpin from a major periodontopathogen Tannerella forsythia inhibits both endogenous and human neutrophil serine proteases Miroslaw Ksi ąż ek (Jagiellonian University, Krakow, Poland and University of Louisville, Louisville, KY, USA) O4.02 16:45-17:00 Structure-Function-Relationships in Hsp47 Ulrich Baumann (Cologne University, Germany) O4.03 17:00-17:30 Identifying protease targets of the Drosophila serine protease inhibitor Serpin42Da James Whisstock (Monash University, Melbourne, Australia) 18:00-19:30 Dinner Poster session 1 19:30 Poster discussion with the authors 11 Specific program March 31 ststst , 2014 Monday, March 31 st , 2014 7:00-8:30 Breakfast and poster mounting 8:30-13:30 “Meet the experts” or free time Oral session V: Serpin conformation, maturation, and/or disposal Chairpersons: Elena Miranda (Italy) and Jim Huntington (UK) O5.01 13:30-14:00 Structural understanding of angiotensinogen:renin interaction Randy Read (University of Cambridge, UK) O5.02 14:00-14:30 SERPIN biosynthetic quality control involves both basal and anticipatory elements Richard N. Sifers (Baylor College of Medicine, Houston, USA) O5.03 14:30-14:45 The PAI-1 latency transition at atomic resolution Pietro Faccioli (University of Trento, Italy) O5.04 14:45-15:15 Characterization of the dynamic structure of PAI-1 using hydrogen/deuterium-exchange mass spectrometry Thomas J.D. Jørgensen (University of Southern Denmark, Denmark) O5.05 15:15-15:30 Structure-based kinetic analysis of the reaction between plasminogen activator inhibitor-1 and urokinase and tissue-type plasminogen activators Jeppe Buur Madsen (Aarhus University, Denmark) 15:30-16:00 Coffee break 12 ststst Specific program March 31 , 2014 Best abstract award lectures 1 Chairpersons: Robert Fluhr (Israel) and Felix Wahlmüller (Austria) A1.01 16:00-16:15 Heparin binding and vaspin/serpinA12 activity David Ulbricht (University of Leipzig, Germany) A1.02 16:15-16:30 The shape of Z-α1-antitrypsin polymers in solution, support the mechanism of self-terminating polymer growth M.A. Behrens (Aarhus University, Denmark) Oral session VI: Evolution of serpins Chairpersons: Robert Fluhr (Israel) and Felix Wahlmüller (Austria) O6.01 16:30-17:00 Tracing the roots of coagulation control and blood pressure regulation by serpins Hermann Ragg (Bielefeld University, Germany) O6.02 17:00-17:15 Natural and artificial selection in hexaploid bread wheat has produced a complex set of differentially expressed active and inactive serpin genes: implications for function Thomas H. Roberts (Macquarie University, Australia) O6.03 17:15-17:30 Co-evolution of a serpin, its target serine protease, and protease substrate Agneszka Jendroszek (Aarhus University, Denmark) 18:00-19:30 Dinner Poster session 2 19:30 Poster discussion with the authors 13 Specific program April 1 ststst , 2014 Tuesday, April 1 st , 2014 7:00-8:30 Breakfast Oral session VII: Serpins in neurobiology Chairpersons: Marie-Christine Bouton (France) and Paul Declerck (Belgium) O7.01 8:30-9:00 The tPA-serpins axis is a key regulator of neuronal fate Denis Vivien (Inserm U919, Caen, France) O7.02 9:00-9:15 Neuroserpin polymer toxicity in a neuronal model of FENIB Claudia Moriconi (Sapienza University of Rome, Italy) O7.03 9:15-9:30 Tissue Plasminogen Activator (tPA) modulates ischaemia- induced endoplasmic reticulum (ER) stress in cultured neurons Benoit Roussel (Inserm U919, Caen, France) O7.04 9:30-10:00 Lipase involvement in the retina-protective effects of PEDF S. Patricia Becerra (National Eye Institute, NIH, Bethesda, USA) 10:00-10:30 Coffee break Oral Session VIII: Non-mammalian serpins Chairpersons: Jan Potempa (USA) and James Whisstock (Australia) O8.01 10:30-11:00 Serpins control programmed cell death during abiotic and biotic stress Robert Fluhr (Weizmann Institute of Science, Rehovot, Israel) 14 ststst Specific program April 1 , 2014 O8.02 11:00-11:30 Drosophila serpins in immunity and development Jean-Marc Reichhart (Université de Strasbourg, France) O8.03 11:30-12:00 Serpins as Therapy – from Virus to Man Alexandra Lucas (University of Florida, Gainesville, USA) 12:00-13:30 Lunch Oral session IX: Serpin-related diseases: cellular injury, disease modifiers, and therapeutic approaches Chairpersons: Cliff J. Luke (USA) and Richard N. Sifers (USA) O9.01 13:30-14:00 How and why the Z-variant of alpha-1-antitrypsin polymerizes, and what can be done about it James A. Huntington ( University of Cambridge, UK) O9.02 14:00-14:15 Modeling rare alpha-1 antitrypsin variants in C. elegans Erin Cummings (University of Pittsburgh Medical School, USA) O9.03 14:15-14:30 A genome-wide high-content RNAi screen, using a C.elegans model of ATD, identifies genetic modifiers and drug targets Linda P. O'Reilly (University of Pittsburgh Medical School, USA) O9.04 14:30-14:45 A single-chain variable fragment antibody against Z alpha1-antitrypsin prevents intracellular polymerization Elena Miranda (Sapienza University of Rome, Italy) O9.05 14:45-15:00 The P1 residue determines the fate of ZPI-protease complex Aiwu Zhou (Shanghai Jiao Tong University School of Medicine, China) 15 Specific program April 1 ststst , 2014 O9.06 15:00-15:15 Protease exosites regulate heparin-catalyzed factor XIa inactivation by antithrombin Ingrid M. Verhamme (Vanderbbilt University School of Medicine, Nashville, TN, USA) O9.07 15:15-15:30 Mutations creating new glycosylation sites cause different types of antithrombin deficiency. Role of an N-glycan at the reactive centre loop Sonia Aguila , (University of Murcia, Spain) 15:30-16:00 Coffee break Best abstract award lectures 2 Chairpersons: Charaf Benarafa (Switzerland) and Chris Overall (Canada) A2.01 16:00-16:15 A fluorescent probe study of protein Z dependent protease inhibitor (ZPI) interaction with protein Z Xin Huang (University of Illinois at Chicago, Chicago,