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ACE Inhibitors: Captopril, Enalapril, Lisinopril

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ACE Inhibitors: Captopril, Enalapril, Lisinopril ACE Inhibitors: Captopril, Enalapril, Lisinopril Heart medicine for your child. What is an ACE ACE (angiotensin-converting enzyme) inhibitors reduce blood pressure by causing the blood vessels to relax. Lower blood pressure makes it easier for inhibitor? the heart to pump blood to areas of the body that need it. What are the types The three common types are Captopril (Capoten), Enalapril (Epaned or Vasotec) and Lisinopril (Zestril or Prinivil). The difference between them is of ACE inhibitors? how often they need to be taken. How do I give an • Give it as prescribed by your doctor. ACE inhibitor to • Give it at the same time every day. The time between doses is important because doses given too close together may lower your child’s blood my child? pressure too much. • The medicine works best when a certain level is in your child’s blood at all times. This happens when the doses are spaced apart in equal amounts of time. What if we miss or If your child takes medicine 3 or 4 times a day: forget a dose? • Skip the dose you forgot and resume the regular schedule. • Do not try to catch up or give a double dose. If your child takes medicine 2 times a day: • If you missed the morning dose: • If you remember the morning dose before noon, give the dose when you remember and stay on the regular schedule. • If you missed the evening dose: • If you remember the dose before midnight, give the dose when you remember and stay on the regular schedule. Call your child’s healthcare provider or the Heart Center if your child misses more than 2 doses of any medicine. 1 of 2 To Learn More Free Interpreter Services • Heart Center • In the hospital, ask your nurse. 206-987-2015 • From outside the hospital, call • After hours and on weekends (hospital the toll-free Family Interpreting operator) - 206-987-2000 Line, 1-866-583-1527. Tell the interpreter the name or extension • Pediatric Cardiology of Alaska you need. 907-339-1945 • Ask your child’s healthcare provider • seattlechildrens.org ACE Inhibitors: Captopril, Enalapril, Lisinopril What if my child • If your child throws up immediately after taking the medicine, go ahead throws up after and repeat the dose for most medicines. taking this • If your child throws up more than 5 minutes after taking the medicine, do not repeat the dose. medicine? What if I run out of Call your pharmacy when you are close to running out of medicine. Your medicine? pharmacy will contact us about refills. The clinic visit is the best time to make sure your child is getting the right dose and has enough medicine. When do I call the Call us if your child has any of these symptoms: doctor? • Rash not related to illness • Cough that does not go away — lasts for about 1 month • Dizziness, especially when changing positions • Severe headache, fatigue, drowsiness • Low energy level • Infants — eating poorly, sleeping more Remember: • Bring a list of your child’s medicines to each clinic appointment. • Keep all medicines out of the reach of children Seattle Children’s offers interpreter services for Deaf, hard of hearing or non-English speaking patients, family members and legal representatives free of charge. Seattle Children’s will make this information available in alternate formats upon request. Call the 7/21 Family Resource Center at 206-987-2201. This handout has been reviewed by clinical staff at Seattle Children’s. However, your child’s PE029 needs are unique. Before you act or rely upon this information, please talk with your child’s healthcare provider. © 2021 Seattle Children’s, Seattle, Washington. All rights reserved. Patient and Family Education | Heart Center 2 of 2 .
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  • A Comparison of the Tolerability of the Direct Renin Inhibitor Aliskiren and Lisinopril in Patients with Severe Hypertension
    Journal of Human Hypertension (2007) 21, 780–787 & 2007 Nature Publishing Group All rights reserved 0950-9240/07 $30.00 www.nature.com/jhh ORIGINAL ARTICLE A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension RH Strasser1, JG Puig2, C Farsang3, M Croket4,JLi5 and H van Ingen4 1Technical University Dresden, Heart Center, University Hospital, Dresden, Germany; 2Department of Internal Medicine, La Paz Hospital, Madrid, Spain; 31st Department of Internal Medicine, Semmelweis University, Budapest, Hungary; 4Novartis Pharma AG, Basel, Switzerland and 5Novartis Institutes for Biomedical Research, Cambridge, MA, USA Patients with severe hypertension (4180/110 mm Hg) LIS 3.4%). The most frequently reported AEs in both require large blood pressure (BP) reductions to reach groups were headache, nasopharyngitis and dizziness. recommended treatment goals (o140/90 mm Hg) and At end point, ALI showed similar mean reductions from usually require combination therapy to do so. This baseline to LIS in msDBP (ALI À18.5 mm Hg vs LIS 8-week, multicenter, randomized, double-blind, parallel- À20.1 mm Hg; mean treatment difference 1.7 mm Hg group study compared the tolerability and antihyperten- (95% confidence interval (CI) À1.0, 4.4)) and mean sitting sive efficacy of the novel direct renin inhibitor aliskiren systolic blood pressure (ALI À20.0 mm Hg vs LIS with the angiotensin converting enzyme inhibitor À22.3 mm Hg; mean treatment difference 2.8 mm Hg lisinopril in patients with severe hypertension (mean (95% CI À1.7, 7.4)). Responder rates (msDBPo90 mm Hg sitting diastolic blood pressure (msDBP)X105 mm Hg and/or reduction from baselineX10 mm Hg) were 81.5% and o120 mm Hg).
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