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Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease (2011) THE NATIONAL ACADEMIES PRESS This PDF is available at http://nap.edu/13284 SHARE Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease (2011) DETAILS 142 pages | 6 x 9 | PAPERBACK ISBN 978-0-309-22222-8 | DOI 10.17226/13284 CONTRIBUTORS GET THIS BOOK Committee on A Framework for Developing a New Taxonomy of Disease; Board on Life Sciences; Division on Earth and Life Studies; National Research Council FIND RELATED TITLES SUGGESTED CITATION National Research Council 2011. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease. Washington, DC: The National Academies Press. https://doi.org/10.17226/13284. Visit the National Academies Press at NAP.edu and login or register to get: – Access to free PDF downloads of thousands of scientific reports – 10% off the price of print titles – Email or social media notifications of new titles related to your interests – Special offers and discounts Distribution, posting, or copying of this PDF is strictly prohibited without written permission of the National Academies Press. (Request Permission) Unless otherwise indicated, all materials in this PDF are copyrighted by the National Academy of Sciences. Copyright © National Academy of Sciences. All rights reserved. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of... Committee on A Framework for Developing a New Taxonomy of Disease Board on Life Sciences Division on Earth and Life Studies Copyright National Academy of Sciences. All rights reserved. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy ... THE NATIONAL ACADEMIES PRESS 500 Fifth Street NW Washington, DC 20001 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the Committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This study was supported by Contract/Grant No. N01-0D-4-2139 between the National Academy of Sciences and the National Institutes of Health. Any opinions, findings, con- clusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the organizations or agencies that provided support for the project. International Standard Book Number-13: 978-0-309-22222-8 International Standard Book Number-10: 0-309-22222-2 Library of Congress Control Number: 2011943146 Additional copies of this report are available from the National Academies Press, 500 Fifth Street, N.W., Lockbox 285, Washington, DC 20055; (800) 624-6242 or (202) 334- 3313 (in the Washington metropolitan area); Internet, http://www.nap.edu Cover art: Nicolle Rager Fuller, Sayo-Art LLC Photo: © Graham Bell/Corbis Copyright 2011 by the National Academy of Sciences. All rights reserved. Printed in the United States of America Copyright National Academy of Sciences. All rights reserved. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy ... The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Ralph J. Cicerone is president of the National Academy of Sciences. The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Charles M. Vest is president of the National Academy of Engineering. The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examina- tion of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Harvey V. Fineberg is president of the Institute of Medicine. The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy’s purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the Na- tional Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Ralph J. Cicerone and Dr. Charles M. Vest are chair and vice chair, respectively, of the National Research Council. www.national-academies.org Copyright National Academy of Sciences. All rights reserved. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy ... Copyright National Academy of Sciences. All rights reserved. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy ... COMMITTEE ON A FRAMEWORK FOR DEVELOPING A NEW TAXONOMY OF DISEASE SUSAN DESMOND-HELLMANN, (Co-Chair), University of California, San Francisco, CA CHARLES L. SAWYERS, (Co-Chair), Memorial Sloan-Kettering Cancer Center, New York, NY DAVID R. COX, Applied Quantitative Genotherapeutics Unit, Pfizer Inc., San Francisco, CA CLAIRE FRASER-LIGGETT, University of Maryland, School of Medicine, College Park, MD STEPHEN J. GALLI, Stanford University, Stanford, CA DAVID B. GOLDSTEIN, Duke University School of Medicine, Durham, NC DAVID J. HUNTER, Harvard School of Public Health, Boston, MA ISAAC S. KOHANE, Harvard Medical School, Boston, MA MANUEL LLINÁS, Princeton University, Princeton, NJ BERNARD LO, University of California, San Francisco, CA TOM MISTELI, National Cancer Institute, Bethesda, MD SEAN J. MORRISON, University of Texas, Southwestern, TX DAVID G. NICHOLS, The Johns Hopkins University School of Medicine, Baltimore, MD MAYNARD V. OLSON, University of Washington, Seattle, WA CHARMAINE D. ROYAL, Duke University, Durham, NC KEITH R. YAMAMOTO, University of California, San Francisco, CA Staff INDIA HOOK-BARNARD, Study Director MIRSADA KARALIC-LONCAREVIC, Senior Program Associate CARL-GUSTAV ANDERSON, Program Associate ORIN LUKE, Senior Program Assistant AMANDA MAZZAWI, Senior Program Assistant MELINDA DIVITO, Christine Mirzayan Fellow v Copyright National Academy of Sciences. All rights reserved. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy ... BOARD ON LIFE SCIENCES KEITH R. YAMAMOTO (Chair), University of California, San Francisco, CA BONNIE L. BASSLER, Princeton University, Princeton, NJ VICKI L. CHANDLER, Gordon and Betty Moore Foundation, Palo Alto, CA SEAN EDDY, Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA MARK D. FITZSIMMONS, John D. and Catherine T. MacArthur Foundation, Chicago, IL DAVID R. FRANZ, Midwest Research Institute, Frederick, MD LOUIS J. GROSS, University of Tennessee, Knoxville, TN CATO T. LAURENCIN, University of Connecticut Health Center, Farmington, CT BERNARD LO, University of California, San Francisco, CA ROBERT M. NEREM, Georgia Institute of Technology, Atlanta, GA CAMILLE PARMESAN, University of Texas, Austin, TX MURIEL E. POSTON, Skidmore College, Saratoga Springs, NY ALISON G. POWER, Cornell University, Ithaca, NY BRUCE W. STILLMAN, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY CYNTHIA WOLBERGER, Johns Hopkins University School of Medicine, Baltimore, MD MARY WOOLLEY, Research!America, Alexandria, VA Staff FRANCES E. SHARPLES, Director JO L. HUSBANDS, Scholar/Senior Project Director JAY B. LABOV, Senior Scientist/Program Director for Biology Education KATHERINE BOWMAN, Senior Program Officer MARILEE K. SHELTON-DAVENPORT, Senior Program Officer INDIA HOOK-BARNARD, Program Officer KEEGAN SAWYER, Program Officer ANNA FARRAR, Financial Associate CARL-GUSTAV ANDERSON, Program Associate SAYYEDA AYESHA AHMED, Senior Program Assistant ORIN LUKE, Senior Program Assistant AMANDA MAZZAWI, Senior Program Assistant vi Copyright National Academy of Sciences. All rights reserved. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy ... Acknowledgments This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise in accordance with procedures approved by the National Research Council’s Report Review Committee. The purpose of
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