Efficacy of Mesotrione-Based Tank Mixtures and Application Timings Compared to Standards in Irrigated Corn
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2,4-Dichlorophenoxyacetic Acid
2,4-Dichlorophenoxyacetic acid 2,4-Dichlorophenoxyacetic acid IUPAC (2,4-dichlorophenoxy)acetic acid name 2,4-D Other hedonal names trinoxol Identifiers CAS [94-75-7] number SMILES OC(COC1=CC=C(Cl)C=C1Cl)=O ChemSpider 1441 ID Properties Molecular C H Cl O formula 8 6 2 3 Molar mass 221.04 g mol−1 Appearance white to yellow powder Melting point 140.5 °C (413.5 K) Boiling 160 °C (0.4 mm Hg) point Solubility in 900 mg/L (25 °C) water Related compounds Related 2,4,5-T, Dichlorprop compounds Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) 2,4-Dichlorophenoxyacetic acid (2,4-D) is a common systemic herbicide used in the control of broadleaf weeds. It is the most widely used herbicide in the world, and the third most commonly used in North America.[1] 2,4-D is also an important synthetic auxin, often used in laboratories for plant research and as a supplement in plant cell culture media such as MS medium. History 2,4-D was developed during World War II by a British team at Rothamsted Experimental Station, under the leadership of Judah Hirsch Quastel, aiming to increase crop yields for a nation at war.[citation needed] When it was commercially released in 1946, it became the first successful selective herbicide and allowed for greatly enhanced weed control in wheat, maize (corn), rice, and similar cereal grass crop, because it only kills dicots, leaving behind monocots. Mechanism of herbicide action 2,4-D is a synthetic auxin, which is a class of plant growth regulators. -
Herbicide Mode of Action Table High Resistance Risk
Herbicide Mode of Action Table High resistance risk Chemical family Active constituent (first registered trade name) GROUP 1 Inhibition of acetyl co-enzyme A carboxylase (ACC’ase inhibitors) clodinafop (Topik®), cyhalofop (Agixa®*, Barnstorm®), diclofop (Cheetah® Gold* Decision®*, Hoegrass®), Aryloxyphenoxy- fenoxaprop (Cheetah®, Gold*, Wildcat®), fluazifop propionates (FOPs) (Fusilade®), haloxyfop (Verdict®), propaquizafop (Shogun®), quizalofop (Targa®) Cyclohexanediones (DIMs) butroxydim (Factor®*), clethodim (Select®), profoxydim (Aura®), sethoxydim (Cheetah® Gold*, Decision®*), tralkoxydim (Achieve®) Phenylpyrazoles (DENs) pinoxaden (Axial®) GROUP 2 Inhibition of acetolactate synthase (ALS inhibitors), acetohydroxyacid synthase (AHAS) Imidazolinones (IMIs) imazamox (Intervix®*, Raptor®), imazapic (Bobcat I-Maxx®*, Flame®, Midas®*, OnDuty®*), imazapyr (Arsenal Xpress®*, Intervix®*, Lightning®*, Midas®* OnDuty®*), imazethapyr (Lightning®*, Spinnaker®) Pyrimidinyl–thio- bispyribac (Nominee®), pyrithiobac (Staple®) benzoates Sulfonylureas (SUs) azimsulfuron (Gulliver®), bensulfuron (Londax®), chlorsulfuron (Glean®), ethoxysulfuron (Hero®), foramsulfuron (Tribute®), halosulfuron (Sempra®), iodosulfuron (Hussar®), mesosulfuron (Atlantis®), metsulfuron (Ally®, Harmony®* M, Stinger®*, Trounce®*, Ultimate Brushweed®* Herbicide), prosulfuron (Casper®*), rimsulfuron (Titus®), sulfometuron (Oust®, Eucmix Pre Plant®*, Trimac Plus®*), sulfosulfuron (Monza®), thifensulfuron (Harmony®* M), triasulfuron (Logran®, Logran® B-Power®*), tribenuron (Express®), -
Exposure to Herbicides in House Dust and Risk of Childhood Acute Lymphoblastic Leukemia
Journal of Exposure Science and Environmental Epidemiology (2013) 23, 363–370 & 2013 Nature America, Inc. All rights reserved 1559-0631/13 www.nature.com/jes ORIGINAL ARTICLE Exposure to herbicides in house dust and risk of childhood acute lymphoblastic leukemia Catherine Metayer1, Joanne S. Colt2, Patricia A. Buffler1, Helen D. Reed3, Steve Selvin1, Vonda Crouse4 and Mary H. Ward2 We examine the association between exposure to herbicides and childhood acute lymphoblastic leukemia (ALL). Dust samples were collected from homes of 269 ALL cases and 333 healthy controls (o8 years of age at diagnosis/reference date and residing in same home since diagnosis/reference date) in California, using a high-volume surface sampler or household vacuum bags. Amounts of agricultural or professional herbicides (alachlor, metolachlor, bromoxynil, bromoxynil octanoate, pebulate, butylate, prometryn, simazine, ethalfluralin, and pendimethalin) and residential herbicides (cyanazine, trifluralin, 2-methyl-4- chlorophenoxyacetic acid (MCPA), mecoprop, 2,4-dichlorophenoxyacetic acid (2,4-D), chlorthal, and dicamba) were measured. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression. Models included the herbicide of interest, age, sex, race/ethnicity, household income, year and season of dust sampling, neighborhood type, and residence type. The risk of childhood ALL was associated with dust levels of chlorthal; compared to homes with no detections, ORs for the first, second, and third tertiles were 1.49 (95% CI: 0.82–2.72), 1.49 (95% CI: 0.83–2.67), and 1.57 (95% CI: 0.90–2.73), respectively (P-value for linear trend ¼ 0.05). The magnitude of this association appeared to be higher in the presence of alachlor. -
CFS Science Comments I
April 27, 2012 Docket No. APHIS–2010–0103 Regulatory Analysis and Development PPD, APHIS Station 3A-03.8 4700 River Road Unit 118 Riverdale, MD 20737-1238 Comments to USDA APHIS on Environmental Assessment for the Determination of Nonregulated Status of Herbicide-Tolerant DAS-40278-9 Corn, Zea mays, Event DAS- 40278-9 Center for Food Safety, Science Comments I – By Bill Freese, Science Policy Analyst These comments submitted by Center for Food Safety are one of three sets of comments from our organization. Legal comments and a second set of science comments are also being submitted. The references cited have been uploaded as supporting materials. The filenames for these documents match the citations in the text, and are all incorporated as (e.g. Benbrook 2012). Full citations are included at the end of each section. THE IMPACT OF DAS-40278-9 ON CORN HERBICIDE USE Summary of herbicide use Dow’s DAS-402787-9 corn is genetically engineered for resistance to 2,4-D and quizalofop, and if deregulated would be marketed with additional resistance to glyphosate and likely glufosinate – fostering greater use of three to four herbicide classes. APHIS must assess DAS-42078-9 as Dow intends it to be used, as a weed control system. DAS-40278-9 eliminates the risk of crop injury that currently limits 2,4-D use on corn, and is thus reasonably projected to trigger an up to 30-fold increase in the use of this toxic herbicide on corn, equivalent to a four-fold increase in overall agricultural use of 2,4-D, by the end of the decade. -
MC(' Potential Exposure of Humans to 2
(MC( FUNDAMENTAL AND APPLIED TOXICOLOGY 1:3 3 9-3 4 6 (1981) Potential Exposure of Humans to 2,4,5-T and TCDD in the Oregon Coast Ranges MICHAEL NEWTON" and LOGAN A. NORRISB "Professor of Forest Ecology, Oregon State University, Corvallis; BChief Research Chemist, USDA Forest Service, Corvallis, Oregon ABSTRACT Potential Exposure of Humans to 2,4,5-T and TCDD in Humans may be exposed to herbicides through drift; inges- the Oregon Coast Ranges. Newton, M. and Norris, L.A. tion of wild and domestic meat, vegetables, and fruit; con- (1981). F.undam. AppL Toxicol. 1:339-346. Research on the sumption of water; and dermal contact while handling the use of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) contami- chemicals, equipment, and treated vegetation. The range of -8 nated with 2.5 X 10 parts 2,3,7,8-tetrachlorodibenzo-p- potential exposure extends from zero, if there is no encounter dioxin (TCDD) in forests of the Oregon Coast Ranges per- with the herbicide, to the worst situation where the person has mits estimates of human exposures for both compounds. encountered the highest levels of water contamination, drift Estimated total exposure of nearby ( ^ 1/8 mile distant) resi- exposure, meat contamination, and dermal exposure simul- dents during the first week after application is 0.0039 mg/kg taneously. We have brought estimates of all sources together of 2,4,5-T for a 70-kg adult. Exposure to TCDD in the same to determine the possible range of total exposure from episode would be 1.9 X 10 b ° mg/kg. -
INDEX to PESTICIDE TYPES and FAMILIES and PART 180 TOLERANCE INFORMATION of PESTICIDE CHEMICALS in FOOD and FEED COMMODITIES
US Environmental Protection Agency Office of Pesticide Programs INDEX to PESTICIDE TYPES and FAMILIES and PART 180 TOLERANCE INFORMATION of PESTICIDE CHEMICALS in FOOD and FEED COMMODITIES Note: Pesticide tolerance information is updated in the Code of Federal Regulations on a weekly basis. EPA plans to update these indexes biannually. These indexes are current as of the date indicated in the pdf file. For the latest information on pesticide tolerances, please check the electronic Code of Federal Regulations (eCFR) at http://www.access.gpo.gov/nara/cfr/waisidx_07/40cfrv23_07.html 1 40 CFR Type Family Common name CAS Number PC code 180.163 Acaricide bridged diphenyl Dicofol (1,1-Bis(chlorophenyl)-2,2,2-trichloroethanol) 115-32-2 10501 180.198 Acaricide phosphonate Trichlorfon 52-68-6 57901 180.259 Acaricide sulfite ester Propargite 2312-35-8 97601 180.446 Acaricide tetrazine Clofentezine 74115-24-5 125501 180.448 Acaricide thiazolidine Hexythiazox 78587-05-0 128849 180.517 Acaricide phenylpyrazole Fipronil 120068-37-3 129121 180.566 Acaricide pyrazole Fenpyroximate 134098-61-6 129131 180.572 Acaricide carbazate Bifenazate 149877-41-8 586 180.593 Acaricide unclassified Etoxazole 153233-91-1 107091 180.599 Acaricide unclassified Acequinocyl 57960-19-7 6329 180.341 Acaricide, fungicide dinitrophenol Dinocap (2, 4-Dinitro-6-octylphenyl crotonate and 2,6-dinitro-4- 39300-45-3 36001 octylphenyl crotonate} 180.111 Acaricide, insecticide organophosphorus Malathion 121-75-5 57701 180.182 Acaricide, insecticide cyclodiene Endosulfan 115-29-7 79401 -
Reregistration Eligibility Decision (RED) for Glyphosate
GLYPHOSATE RED September 1993 GLYPHOSATE REREGISTRATION ELIGIBILITY TEAM Office of Pesticide Programs: Special Review and Reregistration Division Eric Feris .................................................. Reregistration Branch Health Effects Division Jane Smith ........................................ Chemical Coordination Branch Krystyna Locke .............................................. Toxicology Branch I Jeff Evans ........................... Occupational and Residential Exposure Branch Randolph Perfetti ......................... Chemistry Branch - Reregistration Support Biological and Economic Analysis Division James G. Saulmon .....................................Biological Analysis Branch Eric Maurer ........................................... Economic Analysis Branch Environmental Fate and Effects Division Candace Brassard ..................................... Ecological Effects Branch Kevin Poff ............................. Environmental Fate and Groundwater Branch Bernice Slutsky ............................ Science Analysis and Coordination Staff Registration Division Mark Perry .......................................... Registration Support Branch Karen P. Hicks ....................................... Fungicide-Herbicide Branch Policy and Special Projects Staff Jean Frane ............................. Food Safety & Regulation Tracking Section Office of General Counsel: Pesticides and Toxic Substances Division Debra Burton ................................................. Pesticides Branch Office of Compliance Monitoring: -
Toxicological Profile for Glyphosate Were
A f Toxicological Profile for Glyphosate August 2020 GLYPHOSATE II DISCLAIMER Use of trade names is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry, the Public Health Service, or the U.S. Department of Health and Human Services. GLYPHOSATE III FOREWORD This toxicological profile is prepared in accordance with guidelines developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for these toxic substances described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The focus of the profiles is on health and toxicologic information; therefore, each toxicological profile begins with a relevance to public health discussion which would allow a public health professional to make a real-time determination of whether the presence of a particular substance in the environment poses a potential threat to human health. The adequacy of information to determine a substance's -
US EPA, Pesticide Product Label, SHARDA GLYPHOSATE 20.5 % +
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
Effects of Chronic Exposure to the Herbicide, Mesotrione, on Spiders
Susquehanna University Scholarly Commons Senior Scholars Day Apr 28th, 12:00 AM - 12:00 AM Effects of Chronic Exposure to the Herbicide, Mesotrione, on Spiders Maya Khanna Susquehanna University Joseph Evans Susquehanna University Matthew Persons Susquehanna University Follow this and additional works at: https://scholarlycommons.susqu.edu/ssd Khanna, Maya; Evans, Joseph; and Persons, Matthew, "Effects of Chronic Exposure to the Herbicide, Mesotrione, on Spiders" (2020). Senior Scholars Day. 34. https://scholarlycommons.susqu.edu/ssd/2020/posters/34 This Event is brought to you for free and open access by Scholarly Commons. It has been accepted for inclusion in Senior Scholars Day by an authorized administrator of Scholarly Commons. For more information, please contact [email protected]. Effects of Chronic Exposure to the Herbicide, Mesotrione on Spiders Maya Khanna, Joseph Evans, and Matthew Persons Department of Biology, Susquehanna University, PA 17870 Tigrosa helluo Trochosa ruricola Mecaphesa asperata Frontinella pyramitela Tetragnatha laboriosa Hogna lenta Pisaurina mira Abstract Methods All spiders were collected on Table 1. The predicted lethality of mesotrione on each spider species based upon soil association levels and species size. Toxicity is predicted to increase with smaller size and Mesotrione is a widely used agricultural herbicide and is frequently used alone or as an adjuvant for the Susquehanna University’s campus. Each spider was housed in a 473 ml (16oz) greater soil contact. Sample sizes for each species are indicated to the left. A total of 615 herbicides glyphosate and atrazine. The effects of mesotrione are largely untested on beneficial non-target spiders were used in this study. species such as spiders. -
(Aminomethyl)Phosphonic Acid, and Glyphosate-Based Formulations for Genotoxicity and Oxidative Stress Using in Vitro Approaches
Evaluation of Glyphosate, (Aminomethyl)phosphonic Acid, and Glyphosate-Based Formulations for Genotoxicity and Oxidative Stress Using In Vitro Approaches Stephanie L. Smith-Roe, Ph.D. Genetic Toxicology Group Biomolecular Screening Branch National Toxicology Program National Institute of Environmental Health Sciences EMGS 50th Annual Meeting September 23, 2019 Disclaimer The findings and conclusions in this presentation are those of the presenter and do not necessarily reflect the views, policies, or conclusions of NTP or any other U.S. Federal agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NTP studies of glyphosate Toxicity Report No. 16: 13-week study with glyphosate in feed (1992) • Nominated by California Regional Water Quality Control Board North Coast Region (1981) – Glyphosate being found in water runoff in areas of use • NTP selected glyphosate for toxicity evaluation because of: – Expanding use – Potential for human exposure – The lack of published reports concerning comprehensive toxicity or carcinogenicity evaluations NTP studies of glyphosate Toxicity Report No. 16: 13-week study with glyphosate in feed (1992) Top dose for rats ∼3,400 mg/kg/day (males & females) Top dose for mice ∼10,800 and ~12,000 mg/kg/day (males & females, respectively) • No gross lesions at necropsy (rats or mice) • Micronucleus assay was negative in male and female mice (also 13-week exposure via feed) • Bacterial mutagenicity tests were negative • ADME studies indicated low absorption -
Thickening Glyphosate Formulations
(19) TZZ _T (11) EP 2 959 777 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 30.12.2015 Bulletin 2015/53 A01N 57/20 (2006.01) A01N 25/30 (2006.01) A01P 13/00 (2006.01) (21) Application number: 15175726.7 (22) Date of filing: 17.08.2009 (84) Designated Contracting States: (71) Applicant: Akzo Nobel N.V. AT BE BG CH CY CZ DE DK EE ES FI FR GB GR 6824 BM Arnhem (NL) HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (72) Inventor: ZHU, Shawn Stormville, NY New York 12582 (US) (30) Priority: 19.08.2008 US 90010 P 09.09.2008 EP 08163910 (74) Representative: Akzo Nobel IP Department Velperweg 76 (62) Document number(s) of the earlier application(s) in 6824 BM Arnhem (NL) accordance with Art. 76 EPC: 11191518.7 / 2 425 716 Remarks: 09781884.3 / 2 315 524 This application was filed on 07-07-2015 as a divisional application to the application mentioned under INID code 62. (54) THICKENING GLYPHOSATE FORMULATIONS (57) The present invention generally relates to a glyphosate formulation with enhanced viscosity, said formulation containing a thickening composition comprising at least one nitrogen- containing surfactant. EP 2 959 777 A1 Printed by Jouve, 75001 PARIS (FR) EP 2 959 777 A1 Description FIELD OF THE INVENTION 5 [0001] The present invention relates to a glyphosate formulations thickened by nitrogen containing surfactants. BACKGROUND OF THE INVENTION [0002] Glyphosate is the most widely used herbicide in the world.