International Journal of Molecular Sciences Review Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System Nicolaj S. Bischoff 1,* , Theo M. de Kok 1, Dick T.H.M. Sijm 1,2, Simone G. van Breda 1 , Jacco J. Briedé 1 , Jacqueline J.M. Castenmiller 2, Antoon Opperhuizen 2, Yolanda I. Chirino 3 , Hubert Dirven 4, David Gott 5, Eric Houdeau 6, Agnes G. Oomen 7, Morten Poulsen 8, Gerhard Rogler 9 and Henk van Loveren 2 1 Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, The Netherlands;
[email protected] (T.M.d.K.);
[email protected] (D.T.H.M.S.);
[email protected] (S.G.v.B.);
[email protected] (J.J.B.) 2 Netherlands Food and Consumer Product Safety Authority, P.O. Box 43006, 3540 AA Utrecht, The Netherlands;
[email protected] (J.J.M.C.);
[email protected] (A.O.);
[email protected] (H.v.L.) 3 Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonóma de México, Mexico City 54090, Mexico;
[email protected] 4 Norwegian Institute of Public Health, P.O. Box 222 Skøyen, 0213 Oslo, Norway;
[email protected] 5 Food Standard Agency, London SW1H9EX, UK;
[email protected] 6 French National Research Institute for Agriculture, Food and Environment (INRAE), 75338 Paris, France;
[email protected] 7 National Institute for Public Health and the Environment, P.O.