Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy
fcell-08-624216 January 7, 2021 Time: 12:24 # 1 REVIEW published: 12 January 2021 doi: 10.3389/fcell.2020.624216 Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy Daniela Ramaccini1,2,3, Vanessa Montoya-Uribe1, Femke J. Aan1, Lorenzo Modesti2,3, Yaiza Potes4, Mariusz R. Wieckowski4, Irena Krga5, Marija Glibetic´ 5, Paolo Pinton2,3,6, Carlotta Giorgi2,3 and Michelle L. Matter1* Edited by: 1 University of Hawaii Cancer Center, Honolulu, HI, United States, 2 Department of Medical Sciences, University of Ferrara, Gaetano Santulli, Ferrara, Italy, 3 Laboratory of Technologies for Advanced Therapy (LTTA), Technopole of Ferrara, Ferrara, Italy, 4 Laboratory Columbia University, United States of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, 5 Reviewed by: Poland, Center of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, 6 Consolato Sergi, Belgrade, Serbia, Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy University of Alberta Hospital, Canada Atsushi Hoshino, Cardiac tissue requires a persistent production of energy in order to exert its pumping Kyoto Prefectural University of Medicine, Japan function. Therefore, the maintenance of this function relies on mitochondria that Helena Viola, represent the “powerhouse” of all cardiac activities. Mitochondria being one of the key University of Western Australia, Australia players for the proper functioning of the mammalian heart suggests continual regulation Marisol Ruiz-Meana, and organization. Mitochondria adapt to cellular energy demands via fusion-fission Vall d’Hebron Research Institute events and, as a proof-reading ability, undergo mitophagy in cases of abnormalities. (VHIR), Spain Ca2C fluxes play a pivotal role in regulating all mitochondrial functions, including *Correspondence: Michelle L.
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