ZC3HC1(Phospho-S354) Polyclonal Antibody

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PRODUCT DATA SHEET Bioworld Technology,Inc. ZC3HC1(Phospho-S354) polyclonal antibody Catalog: BS64402 Host: Rabbit Reactivity: Human,Mouse BackGround: WB: 1:500~1:1000 NIPA (nuclear interaction partner of ALK) is an Storage&Stability: F-box-containing protein that is an essential component Store at 4°C short term. Aliquot and store at -20°C long of the SCF-type E3 ligase (SCFNIPA) complex, a com- term. Avoid freeze-thaw cycles. plex that controls the completion of S-phase and mitotic Specificity: entry . This control is mediated by the ubiquitination and ZC3HC1(Phospho-S354) polyclonal antibody detects subsequent degradation of cell cycle regulatory proteins, endogenous levels of ZC3HC1 protein only when phos- whose oscillation of protein levels is required for proper phorylated at Ser354. cell cycle progression. Expression levels of NIPA are low DATA: in G0/G1 phases and upregulated in S and G2/M phases. The SCFNIPA complex targets nuclear cyclin B1 for ubiquitination in interphase, whereas phosphorylation of NIPA in late G2 phase and mitosis inactivates the complex to allow for accumulation of cyclin B1. NIPA may have an anti-apoptotic role in NPM-ALK-mediated sig- naling events. Product: Western blot (WB) analysis of ZC3HC1(Phospho-S354) polyclonal an- Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, tibody at 1:500 dilution 50% glycerol, pH7.2. Lane1:K562 whole cell lysate(40ug) Molecular Weight: Lane2:A2780 whole cell lysate(40ug) ~ 65kDa Lane3:AML-12 whole cell lysate(40ug) Swiss-Prot: Lane4:Jurkat whole cell lysate(40ug) Q86WB0 Note: Purification&Purity: For research use only, not for use in diagnostic procedure. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific im- munogen and the purity is > 95% (by SDS-PAGE). Applications: Bioworld Technology, Inc. Bioworld technology, co. Ltd. Add： 1660 South Highway 100, Suite 500 St. Louis Park, Add： No 9, weidi road Qixia District Nanjing, 210046, MN 55416,USA. P. R. China. Email: [email protected] Email: [email protected] Tel: 6123263284 Tel: 0086-025-68037686 Fax: 6122933841 Fax: 0086-025-68035151 .

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A Rare Variant in MCF2L Identified Using Exclusion Linkage in A
European Journal of Human Genetics (2016) 24, 86–91 & 2016 Macmillan Publishers Limited All rights reserved 1018-4813/16 www.nature.com/ejhg ARTICLE A rare variant in MCF2L identiﬁed using exclusion linkage in a pedigree with premature atherosclerosis Stephanie Maiwald1,7, Mahdi M Motazacker1,7,8, Julian C van Capelleveen1, Suthesh Sivapalaratnam1, Allard C van der Wal2, Chris van der Loos2, John JP Kastelein1, Willem H Ouwehand3,4, G Kees Hovingh1, Mieke D Trip1,5, Jaap D van Buul6 and Geesje M Dallinga-Thie*,1 Cardiovascular disease (CVD) is a major cause of death in Western societies. CVD risk is largely genetically determined. The molecular pathology is, however, not elucidated in a large number of families suffering from CVD. We applied exclusion linkage analysis and next-generation sequencing to elucidate the molecular defect underlying premature CVD in a small pedigree, comprising two generations of which six members suffered from premature CVD. A total of three variants showed co-segregation with the disease status in the family. Two of these variants were excluded from further analysis based on the prevalence in replication cohorts, whereas a non-synonymous variant in MCF.2 Cell Line Derived Transforming Sequence-like protein (MCF2L, c.2066A4G; p.(Asp689Gly); NM_001112732.1), located in the DH domain, was only present in the studied family. MCF2L is a guanine exchange factor that potentially links pathways that signal through Rac1 and RhoA. Indeed, in HeLa cells, MCF2L689Gly failed to activate Rac1 as well as RhoA, resulting in impaired stress ﬁber formation. Moreover, MCF2L protein was found in human atherosclerotic lesions but not in healthy tissue segments.
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