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Generate Metabolic Map Poster Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000010605Cyc: Streptomyces griseus griseus NBRC 13350 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari lipid II (meso molybdate phosphate a dipeptide diaminopimelate phosphate phosphate α containing) D-gluconate leu N-acetyl- -D-glucosamine phosphate ethanolamine N,N'-diacetylchitobiose predicted predicted predicted ABC ABC ABC RS08280 RS15505 RS28310 RS07610 RS26715 SecE RS01035 RS23550 RS22715 RS22495 RS21885 RS13085 RS11270 RS05565 RS33195 RS20325 RS20000 RS10485 RS19275 RS32110 RS31955 RS02430 RS02425 FtsW RS31515 RS18000 RS31430 FtsY RS17615 RS09100 RS02210 RS04225 RS04220 RS17370 RS09005 RS09000 RS08995 RS30705 RS04105 RS17170 RS02130 RS30605 RS08820 RS03960 RS30375 RS16775 RS16670 YajC NhaA RS16430 RS29835 RS16140 RS08480 MurJ RS16435 RS08600 SecF RS29040 RS16780 MycP EccE RS04020 LeuE RS02135 RS04110 NgcE RS19510 RS19505 RS28165 RS30975 RS30980 RS09105 RS17655 RS31170 RS17960 RS04500 RS17990 RS02345 YidD RS09520 RS04690 RS02465 RS09710 RS04920 RS10355 RS19885 RS20230 RS10815 Eat RS11380 RS21485 RS11900 RS22585 RS22930 RS24045 RS06875 RS26120 RS27100 RS16915 RS07915 TatA transporter transporter transporter of molybdate of phosphate of a dipeptide lipid II (meso diaminopimelate N-acetyl-α-D-glucosamine phosphate phosphate D-gluconate ethanolamine containing) leu N,N'-diacetylchitobiose phosphate molybdate phosphate a dipeptide RS03650 Cofactor, Carrier, and Vitamin Biosynthesis C1 Compound Utilization and Assimilation UDP-N-acetyl- undecaprenyl- a methylated UDP-N-acetyl-α-D- α ε a mature UDP-N-acetyl- (4R)-4-hydroxy- a (1->4)- + N ,N -diacetyl-lysyl- a ribonucleoside a D-tyrosyl- an L-cysteinyl- cob(II)yrinate a,c- Fatty Acid and Lipid Biosynthesis Carboxylate Degradation α adenosylcobinamide a purine 2-oxoglutarate nucleobase menadione NADH H α a lipid II leukotriene-D4 α pyridoxal 5'-phosphate biosynthesis II superpathway of coenzyme A biosynthesis I (bacteria) adenosylcobalamin 2-methyladeninyl adenosylcobamide benzimidazolyl adenosylcobamide Fermentation mixed acid fermentation glycolate and formaldehyde formaldehyde -D-glucosamine diphospho-N- muramoyl-L-alanyl- peptidoglycan -D-muramoyl- 2-oxoglutarate Tyr met Cys a protein -D-glucan F0F1 ATP cob(II)yrinate a,c-diamide [2Fe-2S] iron-sulfur biotin biosynthesis from adenosylcobinamide-GDP mycothiol biosynthesis pyruvate decarboxylation to acetyl CoA I pyruvate fermentation to acetate IV D-alanyl-D-alanine (n) diphosphate [tRNA ] [tRNA ] dGDP + + diamide biosynthesis I salvage from cobalamin glyoxylate propanoyl CoA ribonucleoside within DNA γ-D-glutamyl-meso- γ 1,4-alpha- H H RS30410 biosynthesis II (late cluster biosynthesis 8-amino-7-oxononanoate I salvage from cobinamide II biosynthesis from adenosylcobinamide-GDP biosynthesis from adenosylcobinamide-GDP pyruvate fermentation oxidation III oxidation V acetylmuramoyl- D-alanyl-D-alanine (meso-DAP L-alanyl- -D- vitamin B12- amino-acid N- ATP-dependent synthase (early cobalt insertion) degradation I γ 5'-triphosphate vitamin B12- glucan cobalt incorporation) 3-methyl-2- a 5,10- D-glucopyranose palmitate biosynthesis (type II fatty acid synthase) long-chain fatty degradation I a [pyruvate dehydrogenase (mycothiol-dependent) (bacillithiol-dependent) L-alanyl- -D- 2,6-diaminopimelate containing) glutamyl-meso-2,6- dependent acetyltransferase: Clp protease: aldehydo-D-ribose D-glyceraldehyde gln (8S)-8-amino-7- cob(I)alamin octanoyl-[acyl-carrier CDP-diacylglycerol phosphoenolpyruvate pyruvate to acetate II NADH-quinone D-alanyl-D-alanine D-alanyl-D-alanine bifunctional membrane dependent branching uroporphyrinogen-III oxobutanoate methylenetetrahydrofolate cob(II)inamide 6-phosphate 2-methyladenine benzimidazole 6 glutamyl-L-lysyl- alpha- diaminopimeloyl- ribonucleotide D-tyrosyl- SGR_RS20430 peptidyl-tRNA SGR_RS24530 uroporphyrinogen-III L-cysteine desulfurase 5-phosphate 3-phosphate oxononanoate protein] biosynthesis biosynthesis I acid activation glycolate propanoyl-CoA E2 protein] N -lipoyl-L-lysine formaldehyde formaldehyde bifunctional oxidoreductase carboxypeptidase/ carboxypeptidase/ 4-hydroxy-2- dipeptidase: ribonucleotide enzyme: bifunctional adenosylmethionine- pyruvate pyruvate pyruvate D-alanyl-D-alanine ketoglutarate- UDP-N- lytic murein D-alanyl-D-alanine reductase: tRNA(Tyr) hydrolase: SGR_RS24535 citrate RS28890 citrate bifunctional inositol-3- nicotinate-nucleotide-- nicotinate-nucleotide-- an acetoacetyl-[acp] (mitochondria, yeast) a long-chain acyl-CoA 3-oxoadipate UDP-N- adenosylcobinamide subunit NuoK: nuoK D-alanyl-D-alanine- D-alanyl-D-alanine- oxoglutarate SGR_RS22255 bifunctional reductase: glgB uroporphyrinogen-III 3-methyl-2-oxobutanoate -8-amino-7- cob(I)yrinic acid pyruvate kinase: pyk phosphoenolpyruvate pyruvate dehydrogenase pyruvate dependent acetylmuramoyl- transglycosylase: SGR_RS08385 deacylase: SGR_RS07165 clpX α RS09765 uroporphyrinogen-III cysteine pyridoxal 5'- phosphate dimethylbenzimidazole dimethylbenzimidazole DHAP fatty acid carboxylase: citrate degradation degradation acetylglucosamine- kinase/ endopeptidase: dacB endopeptidase: dacB aldolase/2- membrane glutamate N- SGR_RS08385 a (1,6)- -D- C-methyltransferase/ desulfurase: hydroxymethyltransferase: oxononanoate a,c-diamide synthase: cob(II)alamin an acetoacetyl-[acp] long-chain fatty pyruvate kinase: pyk carboxylase: ppc dehydrogenase: (acetyl- dehydrogenase: S-(hydroxymethyl) S-(hydroxymethyl) dioxygenase tripeptide--D- NADH-quinone SGR_RS27580 SGR_RS19720 acetyltransferase/ [+ 2 isozymes] glucosyl-(1,4) C-methyltransferase/ phosphate phosphoribosyltransferase: phosphoribosyltransferase: 3-oxoacyl-[acyl- glycerol-3- glyoxylate SGR_RS09560 -N-acetylmuramyl- adenosylcobinamide- penicillin- D-alanyl-D-alanine penicillin- dehydro-3-deoxy- dipeptidase: ribonucleoside- ATP-dependent uroporphyrinogen- SGR_RS27925 panB transaminase: adenosyltransferase: SGR_RS05410 3-oxoacyl-[acyl- acid--CoA ligase: SGR_RS06670 transferring), SGR_RS06670 an acetyl-holo mycothiol bacillithiol AlkB: alanyl-D- alanine oxidoreductase: nuoN [+ 3 isozymes] amino-acid ribonucleoside- -α-glucan acetate acetate uroporphyrinogen- synthase: superpathway of tetrahydrofolate biosynthesis cob(I)yrinic acid cobT cobT carrier-protein] phosphate SGR_RS09565 acetyl-CoA formate 3-oxoadipate (pentapeptide) phosphate binding carboxypeptidase/ binding phosphogluconate SGR_RS01670 diphosphate Clp protease III synthase: acyl carrier asp SGR_RS31400 SGR_RS10595 carrier-protein] SGR_RS20940 oxaloacetate glyoxylate dihydrolipoyl homodimeric acetyl-CoA [citrate lyase acyl- S-(hydroxymethyl) SGR_RS07515 ligase: murF SGR_RS14705 nuoK acetyltransferase diphosphate RS28290 III synthase: cysteine pdxS pdxT inositol-3- a,c-diamide reductase: fabG dehydrogenase: pyruvate [+ 2 isozymes] citrate 3-oxoadipate- S-(hydroxymethyl) pyrophosphoryl- guanylyltransferase: protein D-alanyl-D-alanine- protein aldolase: eda reductase: proteolytic SGR_RS20650 protein activation (7R,8S)-diaminononanoate cob(I)yrinic acid nicotinate-nucleotide-- nicotinate-nucleotide-- reductase: fabG carboligase: (S)-methylmalonyl- dehydrogenase: type: aceE SGR_RS14720 nuoI Tyr Cys reductase: a metal a metal desulfurase: 2-dehydropantoate phosphate 3-oxoacyl-ACP SGR_RS09430 [+ 10 isozymes] carrier protein] -succinyl-CoA mycothiol mycothiol undecaprenol N- SGR_RS26610 alpha- a mature GlcNAc-1,6- endopeptidase: dacB 2: mrdA SGR_RS11310 D-tyrosine a tRNA ArgJ: argJ cys a tRNA subunit: RS10295 SGR_RS20650 aspartate 1- a,c-diamide adenosyltransferase: dimethylbenzimidazole dimethylbenzimidazole a long-chain malate gcl CoA lpdA phosphate phosphate nuoH SGR_RS14735 2: mrdA SGR_RS11310 cation cation uroporphyrinogen-III SGR_RS09975 synthase: reductase 3-oxoacyl-ACP sn-glycerol [+ 4 isozymes] transferase dehydrogenase: dehydrogenase: acetylglucosamine ketoglutarate- UDP-N-acetyl-α-D- peptidoglycan anhMurNAc- leukotriene-E4 SGR_RS11315 N-acetyl-L- SGR_RS31445 acetate acetate an apo acyl- decarboxylase: GTP ATP-dependent SGR_RS10595 phosphoribosyltransferase: phosphoribosyltransferase: fatty acyl-CoA acetyltransferase: pta acetyltransferase: pta adenosyl- nuoF nuoE (n) penicillin- gly a 2'- SGR_RS11315 C-methyltransferase: uroporphyrinogen-III PLP adenosyltransferase: reductase 3-phosphate dehydrogenase: tartronate methylmalonyl- citrate lyase SGR_RS29055 SGR_RS29055 transferase: dependent γ methionine an S-sulfanyl-[L- carrier protein SGR_RS03725 dethiobiotin SGR_RS18230 cobT cobT FabG: fabG a [pyruvate dehydrogenase a [pyruvate dehydrogenase subunit B: cobinamide muramoyl-L-alanyl- SGR_RS14750 (meso-DAP L-Ala- -D-Glu- binding a N- glyoxylate pyruvate deoxyribonucleoside a peptide RS03465 C-methyltransferase: cobO cob(I)yrinic acid SGR_RS13380 CoA 6 subunit beta: α ε cobA holo-ACP FabG: fabG semialdehyde E2 protein] N - 6 SGR_RS06760 SGR_RS13195 dioxygenase γ-D-glutamyl-meso- N ,N -diacetyl- containing) DAP-D-Ala GDP a metal a metal cobA cysteine desulfurase] GTP synthetase a,c-diamide benzimidazole a (3R)-3- E2 protein] N -S- acetyl phosphate
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