Making the Right Moves a Practical Guide to Scientifıc Management for Postdocs and New Faculty
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Medical Advisory Board September 1, 2006–August 31, 2007
hoWard hughes medical iNstitute 2007 annual report What’s Next h o W ard hughes medical i 4000 oNes Bridge road chevy chase, marylaNd 20815-6789 www.hhmi.org N stitute 2007 a nn ual report What’s Next Letter from the president 2 The primary purpose and objective of the conversation: wiLLiam r. Lummis 6 Howard Hughes Medical Institute shall be the promotion of human knowledge within the CREDITS thiNkiNg field of the basic sciences (principally the field of like medical research and education) and the a scieNtist 8 effective application thereof for the benefit of mankind. Page 1 Page 25 Page 43 Page 50 seeiNg Illustration by Riccardo Vecchio Südhof: Paul Fetters; Fuchs: Janelia Farm lab: © Photography Neurotoxin (Brunger & Chapman): Page 3 Matthew Septimus; SCNT images: by Brad Feinknopf; First level of Rongsheng Jin and Axel Brunger; iN Bruce Weller Blake Porch and Chris Vargas/HHMI lab building: © Photography by Shadlen: Paul Fetters; Mouse Page 6 Page 26 Brad Feinknopf (Tsai): Li-Huei Tsai; Zoghbi: Agapito NeW Illustration by Riccardo Vecchio Arabidopsis: Laboratory of Joanne Page 44 Sanchez/Baylor College 14 Page 8 Chory; Chory: Courtesy of Salk Janelia Farm guest housing: © Jeff Page 51 Ways Illustration by Riccardo Vecchio Institute Goldberg/Esto; Dudman: Matthew Szostak: Mark Wilson; Evans: Fred Page 10 Page 27 Septimus; Lee: Oliver Wien; Greaves/PR Newswire, © HHMI; Mello: Erika Larsen; Hannon: Zack Rosenthal: Paul Fetters; Students: Leonardo: Paul Fetters; Riddiford: Steitz: Harold Shapiro; Lefkowitz: capacity Seckler/AP, © HHMI; Lowe: Zack Paul Fetters; Map: Reprinted by Paul Fetters; Truman: Paul Fetters Stewart Waller/PR Newswire, Seckler/AP, © HHMI permission from Macmillan Page 46 © HHMI for Page 12 Publishers, Ltd.: Nature vol. -
The Protein That Wasn't There: the Discovery of Ribozymes
The Protein that Wasn't There: The Discovery of Ribozymes Introduction If we were challenged to describe, in layman's terms, what makes living matter different from non-living matter, I suspect that many of us would focus on nucleic acids. Their ability to encode information, to replicate, and their passage from one generation to the next is part and parcel of what makes life special. Ironically, if one examines an organism carefully and observes what makes it "alive," nucleic acids turn out to have very little direct effect on living matter. Whether an animal moves, breathes, digests, turns its head to look, or just blinks an eye, its actions depend far more on enzymes than they do on DNA. Enzymes in muscle produce movement, in nerve cells they open membrane channels that produce message-carrying impulses, throughout the body enzymes produce, store, and convert chemical energy from one form to another. Enzymes are biological catalysts. Enzymes, which lower the activation energies of chemical reaction, are responsible for just about every activity that we associate with living things. Indeed, enzymes even control the synthesis, replication, folding, and activation of DNA itself. What kinds of molecules are there marvelous enzymes? They are proteins, of course. Look at any biology text, high school or college (including pp. 74-76 of Biology by Miller and Levine), and you will find that they devote a generous amount of space (and lots of pictures) to the structure of proteins. They are loaded with terms like a- helix, b- sheet, prosthetic group, secondary structure, and so forth. -
Publish and Flourish Stephen K
Hope College Digital Commons @ Hope College Faculty Publications 2012 Publish and Flourish Stephen K. Taylor Hope College, [email protected] Follow this and additional works at: http://digitalcommons.hope.edu/faculty_publications Part of the Chemistry Commons Recommended Citation Taylor, Stephen K. Publish and Flourish Faculty Publications, 2012. This Book is brought to you for free and open access by Digital Commons @ Hope College. It has been accepted for inclusion in Faculty Publications by an authorized administrator of Digital Commons @ Hope College. For more information, please contact [email protected]. 1 3 Publish and Flourish Copyright 2012 Stephen K. Taylor Ph.D. All Rights Reserved No part of this book may be reproduced in any form or by any means, electronic or mechanical, including photocopying, record- ing, or by any information storage and retrieval system, without permission in writing from the author. Cover Hope College students working in chemistry laboratories, Courtesy of Hope College. Cover and Interior Design Valerie van Heest Published In the United States of America by Hope College 2012 www.hope.edu 16 15 14 13 12 5 4 3 2 1 First Edition Publisher Cataloging-in-Publication Data Taylor, Stephen K., Ph.D. Publish and flourish: / Stephen K. Taylor, Ph.D. 72 p. : ill., map ; 23 cm. Includes bibliographical references and index (137-142) ISBN 9780963406170 (pbk: alk paper) 1. Education, Higher - Research. 2. College teachers - Research. 3. Academic writing. I. Title II. Author 2012 LB2326.3 .T39 2012 378.0072Tay -
Mckee, Alan (1996) Making Race Mean : the Limits of Interpretation in the Case of Australian Aboriginality in Films and Television Programs
McKee, Alan (1996) Making race mean : the limits of interpretation in the case of Australian Aboriginality in films and television programs. PhD thesis. http://theses.gla.ac.uk/4783/ Copyright and moral rights for this thesis are retained by the author A copy can be downloaded for personal non-commercial research or study, without prior permission or charge This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the Author The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the Author When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given Glasgow Theses Service http://theses.gla.ac.uk/ [email protected] Making Race Mean The limits of interpretation in the case of Australian Aboriginality in films and television programs by Alan McKee (M.A.Hons.) Dissertation presented to the Faculty of Arts of the University of Glasgow in fulfilment of the requirements for the Degree of Doctor of Philosophy University of Glasgow March 1996 Page 2 Abstract Academic work on Aboriginality in popular media has, understandably, been largely written in defensive registers. Aware of horrendous histories of Aboriginal murder, dispossession and pitying understanding at the hands of settlers, writers are worried about the effects of raced representation; and are always concerned to identify those texts which might be labelled racist. In order to make such a search meaningful, though, it is necessary to take as axiomatic certain propositions about the functioning of films: that they 'mean' in particular and stable ways, for example; and that sophisticated reading strategies can fully account for the possible ways a film interacts with audiences. -
NIH Conflict of Interest Regs Revised
OCTOBEROCTOBER 2005 www.asbmb.org Constituent Society of FASEB AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY NIH Conflict of Interest Regs Revised SEE PAGE 30 FOR NEW CLARA BENSON TRAVEL FELLOWSHIP AWARD Held in conjunction with EB2006 Custom Antibodies Your Way! Choose the protocol that is right for you! QwikScreen ™: 65 day, 2 rabbit protocol - 4 immunizations, 3 bleeds/rabbit (~100ml serum), customer supplied peptide/protein - Options: Peptide synthesis, immunograde Conjugation to carrier u ELISA u u Animal extensionsMS analysis $685 Standard: 80 day, 2 rabbit protocol - 5 immunizations, 5 bleeds/rabbit (~ 200ml ser Options: um), ELISA, customer supplied peptide/pr Peptide synthesis MS Check™ peptide sequence confirmation u HPLC purified peptide Affinity purification otein - Pinnacle: $975 u HPLC and MS analysis u Complete Affinity Purified Protocol- Animal extensions 2 rabbit pr 5 bleeds/rabbitotocol, (~ 200mlepitope serum), design, peptide PhD technical synthesis support, (up to 20mer),5 immunizations, HPLC purified to ~85%, 5+mg peptide to customer, ELISA, evaluation period, affinity purification, and morMS Check™ peptide sequence confirmationNo Hidden Charges! e… - Discounts for Multiple Protocols$1795 , Includes peptide sequencing by CID MS/MS– u Guaranteed Peptide Let our enthusiasm for scienceExpert workTechnical for SupportFidelity! P: 508.303.8222 www.21stcenturybio.com Toll-free: 877.217.8238 F: 508.303.8333 you! E: [email protected] www.asbmb.org AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY OCTOBER -
Bringing RNA Into View: RNA and Its Roles in Biology. INSTITUTION Biological Sciences Curriculum Study, Colorado Springs
DOCUMENT RESUME ED 468 800 SE 064 476 AUTHOR Atkins, John F.; Ellington, Andrew; Friedman, B. Ellen; Gesteland, Raymond F.; Noller, Harry F.; Pasquale, Stephen M.; Storey, Richard D.; Uhlenbeck, Olke C.; Weiner, Alan M. TITLE Bringing RNA into View: RNA and Its Roles in Biology. INSTITUTION Biological Sciences Curriculum Study, Colorado Springs. SPONS AGENCY National Science Foundation, Arlington, VA. PUB DATE 2000-00-00 NOTE 194p. CONTRACT NSF-9652921 AVAILABLE FROM BSCS, Pikes Peak Research Park, 5415 Mark Dabling Blvd., Colorado Springs, CO 80918-3842. Tel: 719-531-5550; Web site: http://www.bscs.org. PUB TYPE Guides Classroom Learner (051) Guides Classroom Teacher (052) EDRS PRICE EDRS Price MF01/PC08 Plus Postage. DESCRIPTORS *Science Activities; Biology; *Genetics; Higher Education; *Instructional Materials; *RNA; Science Instruction ABSTRACT This guide presents a module for college students on ribonucleic acid (RNA) and its role in biology. The module aims to integrate the latest research and its findings into college-level biology and provide an opportunity for students to understand biological processes. Four activities are presented: (1) "RNA Structure:- Tapes to Shapes"; (2) "RNA Catalysis"; (3) "RNA and Evolution"; and (4)"RNA Evolution in Health and Disease." (Contains 28 references.) (YDS) Reproductions supplied by EDRS are the best that can be made from the original document. 00 00 7I- r21 4-1 T COPYAVAILABL U S DEPARTMENT OF EDUCATION Office of Educational Research and Improvement PERMISSION TO REPRODUCE AND EDUCATIONAL RESOURCES INFORMATION DISSEMINATE THIS MATERIAL HAS CENTER (ERIC) BEEN GRANTED BY This document has been reproduced as received from the person or organization hating it. -
No. 22731 ••••••••••••••••••••• 1 Oktober 2 No
Vol. 436 Pretoria, 12 October 2001 No. 22731 ••••••••••••••••••••• 1 Oktober 2 No. 22731 GOVERNMENT GAZETTE, 12 OCTOBER 2001 For purposes 01 reference, all Proclamations, Govemment Aile Proldamasies, Goewermenlskennisgewings, Aigemene Notices, General Notices and Board Notices pubUshed s,. Kennlsgewlngs en Raadskennlsgewlngs gepubllseer, word vir Included In the following table of contanla which thus fonna a verwyBlngsdoelelndes In die volgende InhoudsopgBwe Inge- weekly Index. Let yourself bs gUided by the G_numbs.. In alult wat dus 'n weekllkse Indeks voorstel. Laat uself deur die the rlghthand column: Koerantnommers In die regterhandse kolom lei: CONTENTS INHOUD and weekly Index en weeklikse Indeks psga Gazalfa Bladsy Koerant No. No. No. No. No. No. GOVERNMENT AND GENERAL NOTICES GOEWERMENTS- EN ALGEMENE KENNISGEWINGS Arbeld, Departement van Agriculture, Department of Goewermentskennisgewings GovernmentNotice 962 Compensation for Occupational Injuries R. 964 Fertilizers, Farm Feeds, Agricultural and Diseases Act (130/1993): Increase Remedies and Stock Remedies Act in monthly pensions: Amendment . 3 22721 (36/1947): Regulations: Registration of fertilizers, farm feeds, agricultural reme 963 do.: Amendment of Schedule 4 . 5 22721 dies, stock remedies, sterilising plants AlgemeneKennisgewing and pest control operators, appeals and imports:Amendment . 3 22714 2114 Labour Relations Act (66/1995): Com mission for Conciliation Mediation and General Notices Arbitration: Notice in terms of section 2118 Agricultural Product Standards Act 62 (7)................. .. 3 22730 (119/1990): Standards and requir.m.nts regarding control of the export01 melons Behulslng, Departement van and watermelons: Amendment . 70 22731 AigemeneKennisgewing 2127 Marketing of Agricultural Products Act (47/1996): Request for statutory 2112 Explanatory summary of Disestablish measures on potatoes . 74 22731 ment of South African Housing Trust Limited Bill, 2001 . -
Nobel Laureate Dr. Thomas R. Cech GENERAL LECTURE TECHNICAL
THE 50th EYRING LECTURE Nobel Laureate Dr. Thomas R. Cech is Distinguished Professor at University of Colorado Boulder, Director at University of Colorado BioFrontiers Institute, and Investigator at Howard Hughes Medical Institute. Dr. Cech was raised and educated in Iowa, earning his B.A. in chemistry from Grinnell College in 1970. He obtained his Ph.D. in chemistry from the University of California, Berkeley, and then engaged in postdoctoral research in the department of biology at the Massachusetts Institute of Technology in Cambridge, Massachusetts. In 1978 he joined the faculty of the University of Colorado Boulder, where he became a Howard Hughes Medical Institute Investigator in 1988 and Distinguished Professor of Chemistry and Biochemistry in 1990. In 1982 Dr. Cech and his research group announced that an RNA molecule from Tetrahymena, a single-celled pond organism, cut and rejoined chemical bonds in the complete absence of proteins. Thus RNA was not restricted to being a passive carrier of genetic information, but could have an active role in cellular metabolism. This discovery of self-splicing RNA provided the first exception to the long-held belief that biological reactions are always catalyzed by proteins. In addition, it has been heralded as providing a new, plausible scenario for the origin of life; because RNA can be both an information-carrying molecule and a catalyst, perhaps the first self- reproducing system consisted of RNA alone. In January 2000, Dr. Cech moved to Maryland as president of the Howard Hughes Medical Institute, which is the nation’s largest private biomedical research organization. In addition, HHMI has an $80 million/year grants program that supports science education at all levels (K-12 through medical school) and international research. -
Conserved RNA-Binding Specificity of Polycomb Repressive Complex 2 Is Achieved by Dispersed Amino Acid Patches in EZH2
RESEARCH ARTICLE Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2 Yicheng Long1, Ben Bolanos2†, Lihu Gong3,4†, Wei Liu2, Karen J Goodrich1, Xin Yang3,4, Siming Chen3,4, Anne R Gooding1, Karen A Maegley5, Ketan S Gajiwala2, Alexei Brooun2*, Thomas R Cech1*, Xin Liu3,4* 1Department of Chemistry and Biochemistry, BioFrontiers Institute, Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, United States; 2Worldwide Medicinal Chemistry, Worldwide Research and Development, Pfizer Inc., San Diego, United States; 3Cecil H. and Ida Green Center for Reproductive Biology Sciences, Division of Basic Research, Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, United States; 4Department of Biophysics, UT Southwestern Medical Center, Dallas, United States; 5Oncology Research Unit, Worldwide Research and Development, Pfizer Inc., San Diego, United States Abstract Polycomb repressive complex 2 (PRC2) is a key chromatin modifier responsible for methylation of lysine 27 in histone H3. PRC2 has been shown to interact with thousands of RNA *For correspondence: species in vivo, but understanding the physiological function of RNA binding has been hampered [email protected] (AB); by the lack of separation-of-function mutants. Here, we use comprehensive mutagenesis and [email protected] hydrogen deuterium exchange mass spectrometry (HDX-MS) to identify critical residues for RNA (TRC); interaction in PRC2 core complexes from Homo sapiens and Chaetomium thermophilum, for which [email protected] (XL) crystal structures are known. Preferential binding of G-quadruplex RNA is conserved, surprisingly † These authors contributed using different protein elements. Key RNA-binding residues are spread out along the surface of equally to this work EZH2, with other subunits including EED also contributing, and missense mutations of some of Competing interest: See these residues have been found in cancer patients. -
University of California Is One of the World’S Leading Academic He University of California Is One of the World’S Institutions
UNIVERSITY OF CALIFORNIA CAL STUDENT POPULATION Fall 2001 No. of Students ....... 32,128 Undergraduates .... 23,269 Graduate Students . 8,859 Gender Distribution Male ..................... 15,690 Female .................. 16,438 STUDENT COMPOSITION Fall 2001 A multi-cultural and multi- ethnic campus. No ethnic group forms a majority. Native American ........... 178 Asian/Asian American 10,786 African American ...... 1,131 Hispanic .................... 2,666 Caucasian ................. 11,489 Other ............................. 556 International .............. 2,627 he University of California is one of the world’s leading academic The undergraduate student body No Ethnic Data .......... 2,695 institutions. The school, known throughout the world as “Cal,” can best be characterized by its Tis truly a prototype of a contemporary university. It attracts what diversity; there is no one racial or ethnic majority. Students reflect all age many consider the finest applicant pool in the country, generates an groups, and economic, cultural and geographic backgrounds. This dynamic ethnically and culturally diverse student population on campus, and mix produces the wide range of opinion and perspective essential to a great provides one of the finest learning experiences in the world today. university. WORLD-CLASS FACULTY THE BAY AREA AND STUDENTS Overlooking San Francisco Bay, the campus is a lush and tranquil 1,232-acre oasis in an urban setting. The grounds have retained much of The Berkeley campus is renowned for the size and quality of its libraries and laboratories, the scope of its research and publications, and the distinction of its faculty and students. National rankings consistently place Cal’s undergraduate and graduate programs among the very best. The faculty includes eight Nobel Laureates, 122 members of the National Academy of Sciences, 19 MacArthur Fellows, 81 Fulbright Scholars, three Pulitzer Prize winners and more Guggenheim Fellows (137) than any other university in the country. -
35692 21-9 Legalap1 Layout 1
Government Gazette Staatskoerant REPUBLIC OF SOUTH AFRICA REPUBLIEK VAN SUID-AFRIKA Vol. 567 Pretoria, 21 September 2012 No. 35692 PART 1 OF 2 LEGAL NOTICES A WETLIKE KENNISGEWINGS N.B. The Government Printing Works will not be held responsible for the quality of “Hard Copies” or “Electronic Files” submitted for publication purposes AIDS HELPLINE: 0800-0123-22 Prevention is the cure G12-094626—A 35692—1 2 No. 35692 GOVERNMENT GAZETTE, 21 SEPTEMBER 2012 IMPORTANT NOTICE The Government Printing Works will not be held responsible for faxed documents not received due to errors on the fax machine or faxes received which are unclear or incomplete. Please be advised that an “OK” slip, received from a fax machine, will not be accepted as proof that documents were received by the GPW for printing. If documents are faxed to the GPW it will be the sender’s respon- sibility to phone and confirm that the documents were received in good order. Furthermore the Government Printing Works will also not be held responsible for cancellations and amendments which have not been done on original documents received from clients. TABLE OF CONTENTS LEGAL NOTICES Page BUSINESS NOTICES.............................................................................................................................................. 11 Gauteng..................................................................................................................................................... 11 Eastern Cape............................................................................................................................................ -
Harvard University Honorary Degree Recipients 1989-2014
Harvard University Honorary Degree Recipients 1989-2014 Name Degree Year Name Degree Year Daniel Aaron Litt.D. 2007 Bennett Carter Mus.D. 1994 Edward Abraham S.D. 1997 Robert L. Carter LL.D. 2004 José Antonio Abreu Mus.D. 2013 Thomas Cech S.D. 2010 Chinua Achebe Litt.D. 1996 Henry Chadwick D.D. 1997 John Adams Mus.D. 2012 Alfred D. Chandler, Jr. LL.D. 1995 Robert Adams, Jr. LL.D. 1992 Julia Child L.H.D. 1993 Karim the Aga Khan LL.D. 2008 Noam Chomsky LL.D. 2000 Lars Ahlfors S.D. 1989 Steven Chu S.D. 2009 Hélene Ahrweiler LL.D. 1995 Kenneth B. Clark LL.D. 1989 Madeleine Albright LL.D. 1997 William T. Coleman, Jr. LL.D. 1996 Isabel Allende Litt.D. 2014 James Comer LL.D. 2008 Pedro Almodóvar Art.D. 2009 Philip E. Converse LL.D. 2006 Harold Amos S.D. 1996 Sir David Cox S.D. 1999 Kofi Annan LL.D. 2004 Robert A. Dahl LL.D. 1998 Walter H. Annenberg L.H.D. 1996 D. Ronald Daniel LL.D. 2005 K. Anthony Appiah LL.D. 2012 Partha Dasgupta LL.D. 2013 Kenneth Arrow LL.D. 1999 Natalie Zemon Davis LL.D. 1996 John Ashbery Litt.D. 2001 Dominique de Menil L.H.D. 1992 Michael Atiyah S.D. 2006 Philippe de Montebello Art.D. 2006 Margaret Atwood Litt.D. 2004 W. Edwards Deming LL.D. 1993 Mary Ellen Avery S.D. 2005 Joan Didion Litt.D. 2009 Bernard Bailyn LL.D. 1999 Plácido Domingo Art.D. 2011 David Baltimore S.D.