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Sphingolipids in Inflammation: from Bench to Bedside

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Sphingolipids in Inflammation: from Bench to Bedside Mediators of Inflammation Sphingolipids in Inflammation: From Bench to Bedside Guest Editors: Kazuyuki Kitatani, Kazuhisa Iwabuchi, Ashley Snider, and Laura Riboni Sphingolipids in Inflammation: From Bench to Bedside Mediators of Inflammation Sphingolipids in Inflammation: From Bench to Bedside Guest Editors: Kazuyuki Kitatani, Kazuhisa Iwabuchi, Ashley Snider, and Laura Riboni Copyright © 2016 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “Mediators of Inflammation.” All articles are open access articles distributed under the Creative Com- mons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Board Anshu Agrawal, USA Christoph Garlichs, Germany Eeva Moilanen, Finland Muzamil Ahmad, India Mirella Giovarelli, Italy Jonas Mudter, Germany Simi Ali, UK Denis Girard, Canada Hannes Neuwirt, Austria Amedeo Amedei, Italy Ronald Gladue, USA Marja Ojaniemi, Finland Jagadeesh Bayry, France Hermann Gram, Switzerland Sandra Helena Penha Oliveira, Brazil Philip Bufler, Germany Oreste Gualillo, Spain Vera L. Petricevich, Mexico Elisabetta Buommino, Italy Elaine Hatanaka, Brazil Carolina T. Piñeiro, Spain Luca Cantarini, Italy Nina Ivanovska, Bulgaria Marc Pouliot, Canada Claudia Cocco, Italy Yona Keisari, Israel Michal A. Rahat, Israel Dianne Cooper, UK Alex Kleinjan, Netherlands Alexander Riad, Germany Jose Crispin, Mexico Magdalena Klink, Poland Sunit K. Singh, India Fulvio D’Acquisto, UK Marije I. Koenders, Netherlands HelenC.Steel,SouthAfrica Pham My-Chan Dang, France Elzbieta Kolaczkowska, Poland Dennis D. Taub, USA Wilco de Jager, Netherlands Dmitri V. Krysko, Belgium Kathy Triantafilou, UK Beatriz De las Heras, Spain Philipp M. Lepper, Germany Fumio Tsuji, Japan Chiara De Luca, Germany Changlin Li, USA Giuseppe Valacchi, Italy Clara Di Filippo, Italy Eduardo López-Collazo, Spain Luc Vallières, Canada Maziar Divangahi, Canada Antonio Macciò, Italy Elena Voronov, Israel Amos Douvdevani, Israel A. Malamitsi-Puchner, Greece Soh Yamazaki, Japan Ulrich Eisel, Netherlands Francesco Marotta, Italy Teresa Zelante, Singapore Stefanie B. Flohé, Germany Donna-Marie McCafferty, Canada Dezheng Zhao, USA Tânia Silvia Fröde, Brazil Barbro N. Melgert, Netherlands Julio Galvez, Spain Vinod K. Mishra, USA Contents Sphingolipids in Inflammation: From Bench to Bedside Kazuyuki Kitatani, Kazuhisa Iwabuchi, Ashley Snider, and Laura Riboni Volume 2016, Article ID 7602526, 2 pages Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential Masayo Aoki, Hiroaki Aoki, Rajesh Ramanathan, Nitai C. Hait, and Kazuaki Takabe Volume 2016, Article ID 8606878, 11 pages Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2 Alena Chumanevich, Piper Wedman, and Carole A. Oskeritzian Volume 2016, Article ID 1503206, 8 pages Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces Loubna Abdel Hadi, Clara Di Vito, and Laura Riboni Volume 2016, Article ID 3827684, 13 pages Role of Sphingolipids in the Pathobiology of Lung Inflammation Riccardo Ghidoni, Anna Caretti, and Paola Signorelli Volume2015,ArticleID487508,19pages Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections Arielle M. Bryan, Maurizio Del Poeta, and Chiara Luberto Volume2015,ArticleID640540,12pages Sphingolipids in High Fat Diet and Obesity-Related Diseases Songhwa Choi and Ashley J. Snider Volume 2015, Article ID 520618, 12 pages Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans Kazuhisa Iwabuchi, Hitoshi Nakayama, Ami Oizumi, Yasushi Suga, Hideoki Ogawa, and Kenji Takamori Volume2015,ArticleID120748,10pages Sphingosine-1-Phosphate and Its Receptors: A Mutual Link between Blood Coagulation and Inflammation Shailaja Mahajan-Thakur, Andreas Böhm, Gabriele Jedlitschky, Karsten Schrör, and Bernhard H. Rauch Volume 2015, Article ID 831059, 11 pages Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling Eunjung Moon, Jeong Eun Han, Sejin Jeon, Jong Hoon Ryu, Ji Woong Choi, and Jerold Chun Volume 2015, Article ID 492659, 12 pages Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts Chenqi Zhao, Uriel Moreno-Nieves, John A. Di Battista, Maria J. Fernandes, Mohamed Touaibia, and Sylvain G. Bourgoin Volume 2015, Article ID 436525, 12 pages Hindawi Publishing Corporation Mediators of Inflammation Volume 2016, Article ID 7602526, 2 pages http://dx.doi.org/10.1155/2016/7602526 Editorial Sphingolipids in Inflammation: From Bench to Bedside Kazuyuki Kitatani,1 Kazuhisa Iwabuchi,2 Ashley Snider,3,4 and Laura Riboni5 1 Tohoku Medical Megabank Organization/Department of Obstetrics and Gynecology, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan 2Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan 3Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA 4Northport Veterans Affairs Medical Center, Northport, NY, USA 5Department of Medical Biotechnology and Translational Medicine, LITA-Segrate, University of Milan, Milan, Italy Correspondence should be addressed to Kazuyuki Kitatani; [email protected] Received 21 January 2016; Accepted 27 January 2016 Copyright © 2016 Kazuyuki Kitatani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Sphingolipids have been appreciated as bioactive lipids that Glycosphingolipids cluster with sphingomyelin and cho- regulate a diverse range of cellular responses [1, 2]. In recent lesterol in plasma membranes, forming lipid microdomains years many efforts of researchers were made to improve our (lipid rafts) considered as platforms for signal transduc- knowledge of sphingolipids in pathophysiological inflamma- tion.K.Iwabuchietal.reviewtheevidenceforbiological tion. Different studies demonstrated that cellular signaling in significance of lactosylceramide-enriched microdomains in inflammatory processes is controlled by ceramide [3], sphin- immunological and inflammatory responses of neutrophils. gosine-1-phosphate (S1P) [4], ceramide-1-phosphate [5], and They also overview the significance of ceramide species and glycosphingolipids (such as lactosylceramide and GM3) [6]. its metabolites in biological functions. A. M. Bryan et al. The molecular mechanisms underlying this signaling have been extensively studied. discuss the findings pointing to the importance of sphin- This special issue is composed of ten articles including golipids in immune responses of macrophages and neu- three research articles and seven review articles. These con- trophils to fungal infections. R. Ghidoni et al. review roles of tributions review important discoveries and provide novel sphingolipid in the pathobiology of lung inflammation. findings that support the multifaceted role of sphingolipids Three research articles discuss novel findings for S1P and in inflammation. its receptors. E. Moon et al. discover an involvement of S1P Dysregulated formation of several sphingolipids includ- in stroke damage in initial and recurrent stroke models. ing S1P and ceramide has been implicated in inflammatory A. Chumanevich et al. reveal that S1P/S1P receptor 2 axis pro- bowel disease (IBD). L. Abdel Hadi et al. describe sphin- motes mast cell angiogenic potential. C. Zhao et al. demon- golipidmetabolismandsignalinginIBDanddiscussthe strate that the sphingolipid pathway controlling S1P levels is potential of sphingolipid-targeted molecules as therapeutic dysregulated in rheumatoid arthritis synovial fibroblasts. In strategies for this disease. addition, M. Aoki et al. and S. Mahajan-Thakur et al. review Metabolic disease, such as obesity and type 2 diabetes, is theevidencepointingtorolesofS1Panditsreceptorsin emerging as a major health crisis in many countries. High fat diet is a primary contributing factor for obesity and its related immune system and blood coagulation system. diseases. S. Choi and A. J. Snider review the evidence for This special issue discusses the topics associated with sphingolipid metabolism and pathobiology in models of high sphingolipid metabolism and pathobiology in inflammation. fat diet. The articles in this special issue not only provide novel 2 Mediators of Inflammation findings in sphingolipid pathobiology, but also discuss the evidence collected from a large number of research arti- cles, giving insight into drug discovery for inflammation- associated diseases. Acknowledgment We are most grateful to many people who contributed to this special issue, whether by writing, advising, or generating the inspiring contributions discussed in the special issue. Kazuyuki Kitatani Kazuhisa Iwabuchi Ashley Snider Laura Riboni References [1] B. Ogretmen and Y. A. Hannun, “Biologically active sphingol- ipids in cancer pathogenesis and treatment,” Nature Reviews Cancer,vol.4,no.8,pp.604–616,2004. [2] L. Riboni, P. Viani, R. Bassi, A. Prinetti, and G. Tettamanti, “The role of sphingolipids in the process of signal transduction,” Progress
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