Harvard Medical School Curriculum Vitae

Date Prepared: November 1, 2018 Name: Kelly Edwards Irwin, M.D., M.P.H. Home Address: 47 Lexington Road, Concord, MA 01742 Office Address: Center for Psychiatric Oncology and Behavioral Sciences Massachusetts General Hospital Cancer Center 55 Fruit Street, Yawkey 10B, Boston, MA 02114 Work Phone: 617-643-4453 Work Email: [email protected] Work Fax: 617-643-4453 Place of Birth: Methuen, Massachusetts

Education

09/97 - 06/01 B.A. Psychology Harvard University (Magna Cum Laude) 08/03 - 06/08 M.D. Medicine Harvard Medical School 07/15 - 05/17 M.P.H. Clinical Effectiveness Harvard School of Public Health

Postdoctoral Training

06/08 - 06/09 Internship Medicine Massachusetts General Hospital 06/09 - 06/12 Residency Psychiatry Massachusetts General Hospital/ McLean Hospital 07/11 - 06/12 Chief Resident Psychopharmacology/ Massachusetts General Hospital Outpatient Psychiatry 07/13 - 06/15 Fellowship Dupont-Warren Massachusetts General Hospital Research Fellowship 07/15 - 06/17 Fellowship Program in Cancer Dana-Farber/Harvard Cancer Outcomes Research Center Training

Faculty Academic Appointments

07/12 – 08/18 Instructor Psychiatry Harvard Medical School 09/18- present Assistant Professor Psychiatry Harvard Medical School

Appointments at Hospitals/Affiliated Institutions

07/12 - present Assistant in Psychiatry Massachusetts General Hospital Psychiatry 07/12 – 06/15 Assistant in Psychiatry McLean Hospital Psychiatry

Other Professional Positions 1 09/01 – 4/03 Volunteer, Community Health Promotion Doctors for Global Health, El Salvador (Sponsored by Pforzheimer Postgraduate Fellowship for Public Service, Harvard University)

09/01 – 4/03 Consultant Doctors of the World (Medicos del Mundo, El Salvador)

06/15 - Present Consultant, Cancer Care and Mental Illness Massachusetts Department of Mental Health (2 hours per month)

Major Administrative Leadership Positions Local 01/99 – 1/00 Campus Coordinator, Project HEALTH Harvard College Harvard undergraduates 07/15 - present Director, Community Psychiatric Oncology Massachusetts General Hospital Center for Psychiatric Oncology and Behavioral Sciences 04/16 - present Director, Collaborative Care and Community Massachusetts General Hospital Engagement Program Center for Psychiatric Oncology and Behavioral Sciences 11/16 - present Conference Organizer, Bridging the Divide: Massachusetts General Hospital Mental Health and Cancer Care Dana-Farber/Harvard Cancer Center 04/17 – 08/18 Medical Director, Clozapine Program Massachusetts General Hospital Schizophrenia Program

Committee Service Local 09/99 - 06/00 Faculty of Arts and Sciences Standing Harvard College Committee for Public Service Student Representative 05/11 - 06/12 MGH Outpatient Clinic Leadership Service Massachusetts General Hospital Committee 07/11 - 06/12 MGH/McLean Adult Psychiatry Residency Massachusetts General Training Committee Hospital/McLean Hospital 07/12 - present MGH Cancer Outcomes Research Program Massachusetts General Hospital 07/12 - present MGH Schizophrenia Program Massachusetts General Hospital 07/15 – present MGH Tobacco Research Program Massachusetts General Hospital 04/16- present MGH Public and Community Psychiatry Massachusetts General Hospital Steering Committee 07/16 – present MGH Cancer Center Equity Program Massachusetts General Hospital 04/17 – present Partners Behavioral Health Integration Massachusetts General Hospital Committee Partners Healthcare 2 06/17 – present Supportive Care Committee, MGH Cancer Massachusetts General Hospital Center 06/17 – present Med-Psych Integration Workgroup, MGH Massachusetts General Hospital Schizophrenia Program 07/17- present Medicaid Accountable Care Organization Partners Healthcare Design Workgroup Professional Societies

2012 – present Massachusetts Medical Society Member 2012- present American Psycho-Oncology Society Member 2013-present Scientific Planning Committee 2013-2016 Abstract Review Committee 2017-present Conference Planning Committee 2014 – present International Psychosocial Oncology Member 2016- present Academy of Consult Liaison Psychiatry Member 2016- Research Committee 2016 – present American Society of Clinical Oncology Member, Allied Health Professions

Editorial Activities Ad Hoc Reviewer Psychosomatics General Hospital Psychiatry Psycho-oncology British Journal of Psychiatry Cancer Schizophrenia Research The Oncologist Journal of Palliative Medicine Clinical Schizophrenia and Related Psychoses Journal of Clinical Psychiatry Psychiatric Services

Other Editorial Activities 2018-present Editorial Board Psychiatric Annals

Honors and Prizes

2001 Thomas Hoopes Prize Harvard College Research excellence for senior thesis

3 2001 Gordon J. Allport Prize Harvard College Research excellence for senior thesis in psychology 2004 Alexandra Miliotis Harvard Medical School Research fellowship in Fellowship pediatric oncology 2005 Neil Samuel Ghiso Harvard Medical School Compassionate care in Fellowship medicine 2013 Dupont Warren Harvard Medical School Post-residency research Fellowship fellowship 2013 Douglas Family Harvard Medical School Excellence in Cancer Foundation Prize Research, awarded to Cancer Outcomes Research Program 2015 MGH Workshop in National Cancer Institute Weeklong intensive Supportive Oncology Sponsored R-25 Training research workshop for Workshop interdisciplinary supportive oncology research 2015 Program in Cancer Dana-Farber/Harvard Cancer Two-year postdoctoral Outcomes Research Center (Sponsored by National fellowship in cancer Training Cancer Institute) outcomes research 2016 Faculty Development MGH Center for Faculty Funding to present research Travel Award Development an invited oral presentation 2016 Finalist, Dlin Fisher Academy of Psychosomatic Best paper submission to Award Medicine national meeting of the Academy of Psychosomatic Medicine 2016 National Loan National Cancer Awarded for loan Repayment Award Institute/National Institutes of repayment for potential as Health clinical researcher 2017 Partners in Excellence Massachusetts General Hospital Excellence in clinical care Award- Clinical Care as a psychiatrist at the MGH Cancer Center 2017 The One Hundred MGH Cancer Center Leader changing how cancer care is delivered 2017 Research Mentee Award Academy of Psychosomatic Promising researcher in Medicine psychosomatic medicine

Report of Funded and Unfunded Projects Past 2012-2013 Schizophrenia and Breast Cancer Care Massachusetts General Cancer Center Principal Investigator ($16,320) Goals of project: To investigate the feasibility of identifying a cohort of patients with schizophrenia and breast cancer utilizing the Research Patient Data Registry

2013 - 2015 Cancer Care for Individuals with Severe Mental Illness Harvard Medical School Dupont-Warren Fellowship Principal Investigator ($68,319) 4 Goals of project: 1. To investigate disparities in cancer care for patients with history of schizophrenia spectrum disorder and breast or lung cancer compared to patients without a history of mental illness 2. To explore barriers and facilitators to cancer care for this population

2014-2015 Role of Beta-Endorphin in Cancer Therapy-Induced Fatigue NIH/National Cancer Institute R01-CA 150226-04 (Fisher) Co-Investigator Goals of project: 1. To examine the features which modulate endorphin responsiveness, including vitamin D status and pigmentation pathway function 2. To examine whether endogenous endorphin release is responsible for radiation fatigue in patients undergoing radiation therapy for breast cancer

2015 - 2016 Proactive Psychiatry Consultation for Patients with Severe Mental Illness American Cancer Society Institutional Review Grant Principal Investigator ($30,000) Goals of project: 1. To develop and pilot proactive psychiatry consultation and case management for patients with severe mental illness at the time of cancer diagnosis 2. To assess the feasibility and acceptability of the care model according to patients, caregivers, and oncology clinicians 3. To explore the impact of the intervention on psychiatric symptoms

2016-2017 Integrating Tobacco Treatment into Cancer Care: A Randomized Controlled Comparative Effectiveness Trial NIH/NCI R01-CA 166147 (Park) Co-Investigator Goals of project: To compare the effectiveness of two tobacco treatments that are integrated into cancer care, in producing abstinence at 6 months.

Current 2017-2022 Alliance to Improve Equity by Advancing Patient-Centered Cancer Care for Underserved Populations in Northeastern Massachusetts Merck Foundation, Alliance for Patient-Centered Care (Percac-Lima) Co-investigator Goals of project: To develop and evaluate patient navigation for patients from community health centers with a new cancer diagnosis and improve the integration of psychosocial care. To compare the impact of patient navigation vs enhanced usual care on the timeliness of cancer treatment, adherence with cancer care, and patient experience.

2017-2019 Proactive Psychiatry Consultation for Individuals with Severe Mental Illness and Cancer: A Collaborative Care Intervention Harvard Risk Management Foundation (CRICO) Principal Investigator ($193,072) Goals of project: 1. To establish a population-based system to identify patients with serious mental illness at cancer diagnosis. 2. To assess the impact of proactive psychiatry consultation vs. enhanced usual care on cancer care for patients with serious mental 5 illness including disruptions in cancer care, patient and caregiver-reported outcomes and healthcare utilization

2017-2019 Bridging the Divide: Engaging Patients and Stakeholders to Promote Equity in Cancer Care for Patients with Serious Mental Illness Patient Centered Outcome Research Institute Engagement Award Principal Investigator ($250,000) Goals of project: 1. To develop a community network to engage patients, caregivers, and stakeholders with the shared purpose of reducing disparities in cancer mortality for patients with SMI 2. To build capacity for patients, caregivers, advocates and other stakeholders to partner in patient-centered outcomes research dedicated to this underserved population 3. To utilize the community network and partnership with the Department of Mental Health to adapt and disseminate best practices targeted to this population

2018-2020 Promoting Equity in Cancer Care for People with Serious Mental Illness The Trefler Program at the Kraft Center for Community Health Principal Investigator ($92,000) Goals of project: To increase access to timely, high quality cancer and supportive care for patients with serious mental illness (SMI) through two initiatives 1)Expanding access to integrated mental health and oncology consultations for patients with SMI not currently accessing cancer care and their clinicians; 2) Increasing capacity for the collaborative care and community engagement program, a team-based approach (psychiatry, social work, community health worker) to proactively identify patients, track outcomes, and increase patient engagement and continuity of care from hospital to the community.

2018-2022 Reducing Disparities in Cancer Care for Individuals with Serious Mental Illness National Cancer Institute/National Institutes of Health/K08 Career Development Award Principal Investigator Goals of project: 1. To assess the impact of proactive psychiatry consultation on cancer care 2. To assess the impact of proactive psychiatry consultation on patient and caregiver-reported outcomes 3. To examine barriers and facilitators to disseminating and implementing proactive psychiatry consultation Impact Score 30, pending council review

Report of Local Teaching and Training Teaching of Students in Courses 2012- Schizophrenia Massachusetts General Hospital 3rd-year Harvard Medical Students 1 hour lecture monthly

2014- MGH Psychiatry Clerkship Massachusetts General Hospital 3rd-year Harvard Medical Students 1 hour-long oral exam every 1-2 months

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Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs) 2011 Outpatient Psychiatry Orientation Massachusetts General Hospital PGY-2 Psychiatry Residents 1-hour lecture 2011 Pages You Get in the Middle of the Massachusetts General Hospital/McLean Hospital Night 1-hour lecture PGY-2 Psychiatry Residents 2011 Antidepressant Medications in Massachusetts General Hospital/McLean Hospital Inpatient and Outpatient Settings 1-hour lecture PGY-1 Psychiatry Residents 2012 Challenging psychiatric patients Massachusetts General Hospital MGH Medicine Residences 1-hour lecture, 6 per year (with Guy Maytal, MD) 2013-present Psychiatric Oncology: Depression, Massachusetts General Hospital Anxiety, and Serious Mental Illness 1-hour lecture, 6 per year (with Carlos Fernandez- Medical Oncology Fellows at MGH Robles, MD) and Dana-Farber Cancer Institute 2016-present Introduction to Psychiatric Massachusetts General Hospital Oncology 1-hour lecture Gynecology-Oncology Fellows 2016-present Integration of Medicine and Massachusetts General Hospital Psychiatric Care for Patients with 1-hour lecture, 4 seminars per year Serious Mental Illness PGY-5 Psychiatry Fellow, PGY-2 Psychiatry Residents 2016-present Cancer 101 Massachusetts General Hospital/McLean Hospital PGY-3 Psychiatry Residents 1-hour lecture per year

Clinical Supervisory and Training Responsibilities

2008 – 2009 Supervision, teaching, and evaluation of Harvard Medical 1 hour daily School students completing clerkships in internal medicine, psychiatry, and neurology 2009 – 2012 Supervising and teaching of MGH/McLean psychiatry 1 hour daily residents and Harvard Medical School students 2011 – 2012 As MGH Psychopharmacology Chief Resident, helped 4 hours daily (average 20 organize curriculum for 20 MGH-based PGY-2 and 3 hours/week) psychiatry residents and performed individual supervision with PGY-3 residents in their outpatient work 2012- present Individual supervision of 1 PGY-2 psychiatry resident 1 3-hour session weekly during 6 week community psychiatry rotation with MGH Schizophrenia Program 2013 – 2014 Individual supervision of MGH PGY-3 psychiatry 1 hour weekly resident 2015- 2016, Individual supervision of PGY-5 Fellow in Community 1 hour weekly 2017- present and Public Sector Psychiatry 2016 – 2018 Individual psychotherapy supervision for PGY-3 resident 1 hour weekly

7 2016- present Individual supervision for psychiatric nurse practitioner 1 hour every other week in clozapine clinic

Mentored Trainees and Faculty

2013-2015 Keri Oxley Brenner, MD, MPA/Instructor in Medicine and Population Health, Stanford University Career stage: Resident, fellow. Mentoring role: Career development. Accomplishments: Oral presentation at Bridging the Divide symposium; now faculty member at Stanford

2014-2015 Helen Knight, BA/4th Year Medical Student, Johns Hopkins University Career stage: Research assistant, Medical student. Mentoring role: Research and career advisor. Accomplishments: Co-authored manuscript, presented invited symposium at International Psychosocial Oncology Society, admitted to Johns Hopkins Medical School

2015-present Lauren E. Fields, BA/1st Year Medical Student, Columbia University Career stage: Research assistant, Medical Student. Mentoring role: Research and career advisor. Accomplishments: Co-authored manuscript, presented posters at local symposium and American Psychosocial Oncology Society, admitted to Columbia Medical School

2015-present Amy E. Corveleyn, MSW/Case Manager, Collaborative Care and Community Engagement Program, Massachusetts General Hospital Career stage: Staff member Mentoring role: Research, clinical and career development. Accomplishments: Presented at the American Psychosocial Oncology Society, International Psychosocial Oncology Society, and American Society of Oncology Social Work, selected for national oncology social work research collaborative.

2016-present Michaela E. Hurley, B.S./Masters Student in Public Health/Tufts University Career stage: Undergraduate and graduate student. Mentoring role: Research supervisor. Accomplishments: Presented poster at MGH Public Psychiatry symposium, accepted to University of Albany Medical School 2017-present Efren J. Flores, MD/Instructor in Radiology, Harvard Medical School Career stage: Faculty. Mentoring role: Research mentor. Accomplishments: Received American Cancer Society Institutional Review Grant, manuscripts in preparation

Formal Teaching of Peers No presentations below were sponsored by outside entities 2016 Clozapine Update 1 hour lecture MGH Outpatient Psychiatry Faculty

Local Invited Presentations No presentations below were sponsored by outside entities

8 2007 Community, Family, and Individual Factors: Childhood Obesity in Chelsea Department of Pediatrics, Massachusetts General Hospital, Chelsea MA

2010 Building an Alliance with Psychotic Patients on the Inpatient Unit/Speaker Bipolar and Psychotic Disorders Unit, McLean Hospital, Belmont, MA

2010 Loss of Control: Headache, Seizure, and Suicidality Medical/Psychiatric Inpatient Unit, Blake 11, MGH

2010 A Good Death: Pediatric Palliative Care and Psychiatry/Speaker Psychosomatics Conference, MGH

2011 Persistent Delirium: Risk Factors, Potential Mechanisms and Strategies for Management/Speaker Psychosomatics Conference, MGH

2012 Is Everyone Pregnant or is it Just Me? MGH/McLean Psychiatry Residency Senior Talks, MGH

2012 MGH Department of Psychiatry Grand Rounds “Spring Series” / Organized five Grand Rounds talks and invited regional experts to speak on the theme “Psychosis in the General Hospital

2013 Just because you’re paranoid doesn’t mean you don’t have cancer: Managing Advanced Cancer in the Schizophrenic Patient/Presenter at Schwartz Rounds MGH Cancer Center

2014 Cancer Care in the Delusional Patient/Presenter at Schwartz Rounds MGH Cancer Center

2015 Breast Cancer Care for Individuals with Schizophrenia/Presenter Breast Oncology Grand Rounds, MGH Cancer Center

2015 Improving Breast Cancer Outcomes for People with Severe Mental Illness/Presenter Program in Cancer Outcomes Research Training Seminar, MGH, Boston, MA

2015 Breast Cancer Care for Patients with Serious Mental Illness/Presenter New England Journal of Medicine Clinicopathological Conference / MGH Psychiatry Departmental Grand Rounds (with Oliver Freudenreich, M.D., Jeffrey Peppercorn, M.D., Nina Sanford, M.D., and Thomas Gudewicz, M.D.) MGH Department of Psychiatry

2015 Improving Cancer Outcomes for People with Severe Mental Illness/Presenter Program in Cancer Outcomes Research Training, MGH

2015 Improving Cancer Outcomes for People with Severe Mental Illness/Presenter Grand Rounds, Center for Addiction Medicine, MGH

2016 Proactive Psychiatry Consultation for Patients with Severe Mental Illness and Cancer 9 Cancer Care Delivery Research Seminar/Presenter Dana-Farber Cancer Institute

2016 Proactive Psychiatry Consultation for Patients with Severe Mental Illness and Cancer MGH Cancer Center Attendings Conference

2016 Proactive Psychiatry Consultation for Patients with Severe Mental Illness at Cancer Diagnosis Program in Cancer Outcomes Research Training Seminar, MGH

2016 Improving Cancer Care for People with Serious Mental Illness Center for Community Health Improvement, MGH Chelsea

2016 “A woman with schizophrenia and lung cancer”/Discussant, HMS Principal Clinical Experience Case Conference Massachusetts General Hospital

2017 Promoting Equity in Cancer Care for Individuals with Serious Mental Illness/Presenter Dana-Farber/Harvard Cancer Center Program in Cancer Outcomes Research Conference MGH Institute of Technology Assessment, Boston, MA

2017 Promoting Equity in Cancer Care for Individuals with Serious Mental Illness/Speaker at Mongan Institute of Health Policy Faculty Conference, MGH, Boston, MA

2017 Promoting Equity in Cancer Care for Individuals with Serious Mental Illness/Speaker MGH Tobacco Research Program Conference, Boston, MA

2017 Promoting Equity in Cancer Care for Individuals with Serious Mental Illness/Plenary Speaker at Bridging the Divide: Mental Health and Cancer Care, a symposium funded by the Dana- Farber Harvard Cancer Center and MGH Cancer Center, The Wyndham Hotel, Boston, MA

2017 Bridging the Divide: Promoting Equity in Cancer Care for Radiology Department Diversity and Inclusion Conference Grand Rounds, Department of Palliative Care and Geriatrics, MGH

2017 Bridging the Divide: Promoting Equity in Cancer Care for People with Serious Mental Illness Grand Rounds, Department of Social Work, Dana-Farber Cancer Institute

Report of Regional, National and International Invited Teaching and Presentations Regional No presentations below were sponsored by outside entities 2016 Improving Cancer Outcomes in People with Serious Mental Illness Medical Grand Rounds, Lemuel Shattuck Hospital, Boston, MA

2016 Improving Cancer Care for Individuals with Severe Mental Illness Massachusetts Department of Mental Health Consolidated Risk Meeting, Tewksbury, MA 10

2016 Reducing Disparities in Cancer Care for People with Severe Mental Illness Massachusetts Department of Mental Health, Lindemann Center Leadership Committee

2017 Promoting Equity in Cancer Care for Individuals with Severe Mental Illness North Suffolk Mental Health, Chelsea, MA

2017 Promoting Equity in Cancer Care for Individuals with Serious Mental Illness Medical Grand Rounds, Lemuel Shattuck Hospital, Boston, MA

2017 Targeted Collaborative Care: Proactive Psychiatry Consultation and Case Management for Individuals with Serious Mental Illness and Cancer/Presenter North Suffolk Mental Health, Chelsea, MA

2017 Promoting Equity in Cancer Care for Patients with Serious Mental Illness Boston College School of Social Work

2017 Bridging the Divide: Promoting Equity in Cancer Care for People with Serious Mental Illness Psychiatry Grand Rounds: North Shore Medical Center

2018 Bridging the Divide: Cancer and Mental Health Care/Presenter North Suffolk Mental Health, Chelsea, MA

National No presentations below were sponsored by outside entities 2014 Breast Cancer Care for Individuals with Schizophrenia (selected abstract) American Psychosocial Oncology Conference, Tampa, FL

2016 Developing the Collaborative Care and Community Engagement Program (selected abstract) American Psychosocial Oncology Conference, San Diego, CA

2016 Cancer Care for Individuals with Schizophrenia: A Qualitative Study of Oncology and Mental Health Clinicians (selected abstract) American Psychosocial Oncology Conference, San Diego, CA

2016 Predictors of Disruptions in Breast Cancer Care for Individuals with Schizophrenia (selected abstract) Academy of Psychosomatic Medicine, Austin, TX

2017 Proactive Psychiatry Consultation for Individuals with Serious Mental Illness: A Pilot Study (selected abstract) American Psychosocial Oncology Conference, Orlando, FL

2017 Tobacco Cessation for Individuals with Serious Mental Illness/Symposium presenter with Elyse Park, PhD and Giselle Perez, PhD (selected abstract) American Psychosocial Oncology Conference, Orlando, FL 11

2017 Cancer Care for Individuals with Serious Mental Illness: Targeted Collaborative Care National Council on Behavioral Health Webinar

2017 Bridging the Divide: Promoting Equity in Cancer Care for People with Serious Mental Illness American Hospital Association Webinar

2018 Translational Health Equity Research: Emerging Models of Collaborative Cancer Care, Science, and Training/Symposium presenter with Charles Kamen, PhD, Yasemin Turkman, PhD, and Marie Flannery, PhD (selected abstract) American Psychosocial Oncology Conference, Tucson, AZ

2018 The Merck Foundation Alliance to Advance Patient-Centered Cancer Care: Decreasing Disparities in Cancer Care for Underserved Patients Through Collaborative Care and Community Partnerships/Symposium chair and presenter with Heidi Hamann, PhD, James Zabora, PhD, Karen Weihs, MD, and Elyse R. Park, PhD, MPH (selected abstract) American Psychosocial Oncology Conference, Tucson, AZ

2018 Integrating Mental Health and Cancer Care for Patients with Mental Illness Association of Oncology Social Work Webinar

International No presentations below were sponsored by outside entities 2006 The Voices of Mothers and Fathers: Understanding of Prognosis and Goals of Care Among Couples whose Child Died of Cancer 16th International Conference on the Care of the Terminally Ill, Montreal, Canada

2014 Disparities in Breast Cancer Care for Individuals with Schizophrenia/selected abstract International Psychosocial Oncology Conference, Lisbon, Portugal

2016 Promoting Equity in Cancer Care for Patients with Severe Mental Illness: Plenary Speaker International Psychosocial Oncology Conference, Dublin, Ireland

2016 Serious Mental Illness and Cancer Care/Symposium Chair and Presenter/selected abstract (with Carlos Fernandez-Robles, MD, Helen Knight, BA, and Amy Corveleyn, MSW) International Psychosocial Oncology Conference, Dublin, Ireland

2017 Bridging the Divide: Promoting Equity in Cancer Care for Patients with Serious Mental Illness Plenary, Psychosocial Oncology Study Day, Dublin, Ireland

2017 Bridging the Divide: Mental Health and Cancer Care Irish Cancer Society, Dublin Ireland

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Report of Clinical Activities and Innovations Current Licensure and Certification

2006 – 2008 Passed U.S. Medical Licensing Examination Step 1, Step 2 CS, Step 2 CK, and Step 3 2008 – 2010 Massachusetts Limited Medical License 2010 –present Massachusetts Full Medical License 2012 - present Board certified in Psychiatry by the American Board of Psychiatry and Neurology

Practice Activities

2012 – present Outpatient adult Psychiatric Oncology, MGH 15 hours/week psychiatry 2012 – present Outpatient adult Schizophrenia Program, MGH 4 hours/week psychiatry Clinical Innovations 2011-2012 Treating Psychotic Disorders in the MGH Psychiatry Residency Clinic (with Oliver Freudenreich, MD). Developed initiative providing focused resident teaching and streamlined clinical care for patients with psychotic disorders with two objectives: 1) increase access to high quality psychiatric care for patients with psychotic disorders seen at MGH, and 2) improve clinical teaching and supervision for residents treating patients with psychotic disorders and prescribing clozapine

2015- present Director and Founder, Collaborative Care and Community Engagement Program Center for Psychiatric Oncology and Behavioral Sciences, MGH Cancer Center Created clinical and research initiative dedicated to achieving equity in cancer care and outcomes for patients with serious mental illness with the following aims: 1) To increase access to clinical care and develop innovative models of care delivery for an underserved population, 2) To conduct research and decrease barriers to clinical trial participation for patients with serious mental illness, 3) To educate clinicians across disciplines and levels of training (oncology, psychiatry, social work, nursing) and 4) To forge community partnerships to increase awareness of cancer health disparities and create mechanisms to disseminate new models of care delivery I developed a model of integrated psychiatry and oncology care targeted to patients with serious mental illness and cancer which incorporates proactive psychiatry consultation and case management. This model has been highlighted in an editorial in the New England Journal of Medicine, presented at national conferences, grand rounds, and shared via national webinars. In 2017, I organized a symposium attended by 150 participants representing 30 institutions. We completed the first pilot study targeting this population and have received funding for a randomized trial of the intervention. Our initiative has been supported by seed funding from the MGH Cancer Center, MGH Department of Psychiatry, and the Massachusetts Department of Mental Health.

2016- present Consultant, Massachusetts Department of Mental Health Director, Second Opinion Service: Increasing Access to Collaborative Care 13 I developed a Second Opinion Service in partnership with the leadership of the MGH Cancer Center with the goal of increasing access to cancer care for individuals with serious mental illness in the community. Mental health clinicians and community members can reach out to our psychiatry team who will connect with an oncologist from the disease center and provide guidance on the best next steps. Approaches include teleconsultation, joint psychiatry and oncology visits, and community-based visits. The Massachusetts Department of Mental Health has recognized the promise of this model by contracting our team as consultants for patients with serious mental illness and cancer.

2017-present Founder and Director, BRIDGE: Inpatient collaborative care for serious mental illness and cancer We responded to feedback from oncology clinicians, patients, and families regarding challenges transitioning from the inpatient setting to the community (e.g. rehab, home, or community mental health setting). We piloted an approach where patients are connected to a social work case manager and psychiatrist during the inpatient stay with the goal of building trust and continuity while helping patients be cared for in the community, aiming to decrease length of stay and prevent unnecessary acute care.

Report of Education of Patients and Service to the Community Activities 2006-2008 Student Director, Tuesday Night Dinners, medical student program providing medical consultation to homeless adults at a community shelter

2013 Guest Speaker, Prostate Cancer Support Group

2013-present Consultant, Massachusetts Department of Mental Health and North Suffolk Mental Health

2015 Speaker, MGH Schizophrenia Education Day

2015-2016 Consultant, Bay Cove Human Services regarding severe mental illness and cancer

Educational Material for Patients and the Lay Community

Books, monographs, articles and presentations in other media

2017 Bridging the Gap Video (MGH Cancer Center

Report of Scholarship Peer reviewed publications in print or other media

14 Original Research

1. Edwards KE, Neville BA, Cook EF, Aldridge SH, Dussel V, Wolfe J. Understanding of prognosis and goals of care among couples whose child died of cancer. J Clin Oncol. 2008 Mar 10; 26(8):1310-1315. PMID: 18323555. 2. Wolfe J, Hammel JF, Edwards KE, Duncan J, Comeau M, Breyer J, Aldridge SA, Grier HE, Berde C, Dussel V, Weeks JC. Easing of suffering in children with cancer at the end of life: is care changing? J Clin Oncol. 2008 Apr 01; 26(10):1717-1723. PMID: 18375901. 3. Greer JA, Irwin K, Lennes IT, Jackson VA, Park ER, Fujisawa D, Wright AA, Temel JS. Processes of discontinuing chemotherapy for metastatic non-small cell lung cancer at the end of life. J Clin Oncol. 2014 Nov; 32(31_suppl):96. PMID: 28142827. 4. Pirl WF, Greer JA, Irwin K, Lennes IT, Jackson VA, Park ER, Fujisawa D, Wright AA, Temel JS. Processes of discontinuing chemotherapy for metastatic non-small-cell lung cancer at the end of life. J Oncol Pract. 2015 May; 11(3):e405-12. PMID: 25829525; PMCID: PMC4438117. 5. Hagan TL, Fishbein JN, Nipp RD, Jacobs JM, Traeger L, Irwin KE, Pirl WF, Greer JA, Park ER, Jackson VA, Temel JS. Coping in patients with incurable lung and gastrointestinal cancers: a validation study of the brief COPE. J Pain Symptom Manage. 2017 Jan; 53(1):131-138. PMID: 27725249. 6. Irwin KE, Park ER, Shin JA, Fields LE, Jacobs JM, Greer JA, Taylor JB, Taghian AG, Freudenreich O, Ryan DP, Pirl WF. Predictors of disruptions in breast cancer care for individuals with schizophrenia. Oncologist. 2017 May 30. PMID: 28559411. doi: 10.1634/theoncologist.2016-0489. [Epub ahead of print] 7. Wong RL, El-Jawahri A, D'Arpino SM, Fuh CX, Johnson PC, Lage DE, Irwin KE, Pirl WF, Traeger L, Cashavelly BJ, Jackson VA, Greer JA, Ryan DP, Hochberg EP, Temel JS, Nipp RD. Use of Antidepressant Medications Moderates the Relationship between Depressive Symptoms and Hospital Length of Stay in Patients with Advanced Cancer. Oncologist. 2018 Aug 6. pii: theoncologist.2018-0096. doi: 10.1634/theoncologist.2018-0096. [Epub ahead of print]

Other Peer-Reviewed Publications 1. Irwin KE, Greer JA, Khatib J, Temel JS, Pirl WF. Early palliative care and metastatic non-small cell lung cancer: potential mechanisms of prolonged survival. Chron Respir Dis. 2013 Feb; 10(1):35-47. PMID: 23355404. 2. Irwin KE, Henderson DC, Knight HP, Pirl WF. Cancer care for individuals with schizophrenia. Cancer. 2014 Feb 01; 120(3):323-34. PMID: 24151022. 3. Irwin, KE. The patients we have to see. The Oncologist 2017 Jun 07. PMID: 28592617. doi: 10.1634/theoncologist.2017-0172. [Epub ahead of print]

Non-peer reviewed scientific or medical publications/materials in print or other media

Proceedings of Meetings 1. Irwin KE, Corveleyn A. “Bridging the Divide in Mental Health and Cancer Care: A Call to Action.” May 5th, 2017, Boston, MA

Editorials 1. Irwin KE. Suicide Risk in Patients with Head and Neck Cancer: An Area of Urgent Need. HemOnc Today. 2016 Sept 10. 2. Irwin KE. Suicide and Lung Cancer. IASLC Lung Cancer News. August 2017.

15 Book Chapters 1. Irwin KE, Smith FA, and Sanders K. Psychosis, Medical vs. Psychiatric. In: Schnaider JJ, Barkin RM, Hayden SR, Wolfe RE, Barkin AZ, Shayne P, and Rosen P, editors. The 5 Minute Emergency Medicine Consult. New York: Lippincott, Williams and Wilkins; 2010. p. 936-937. 2. Nejad S, Dubovsky A, Irwin KE, Governan, J, Fagan S. Burns. In: Fogel BS and Greenberg DB editors. Psychiatric Care of the Medical Patient, 3rd ed. London and New York: Oxford University Press, 2015. p. 1455-1472. 3. Fernandez-Robles C, Pirl WF, Greenberg DB, Irwin KE. Patients with Cancer. In: Stern T, Freudenreich O, Smith FA, Fricchione GL, and Rosenbaum JF, editors. The Massachusetts General Hospital Handbook of General Hospital Psychiatry, 7th ed. Salt Lake City: Elesivier; 2017.

Case Reports 1. Irwin KE, Freudenreich O, Peppercorn J, Taghian AG, Freer PE, Gudewicz TM. Case records of the Massachusetts General Hospital. Case 30-2016. A 63-Year-Old Woman with Bipolar Disorder, Cancer, and Worsening Depression. N Engl J Med. 2016 09 29; 375(13):1270-81. PMID: 27682037. Theses Pathways to Hope: Strategies Used by Inner-City Families to Cope Successfully with Childhood Asthma, Harvard College Department of Psychology, 2001. Abstracts, Poster Presentations, and Exhibits Presented at Professional Meetings

1. Irwin, KE, Meshesha M, Pirl WF, Henderson DC, and Park ER. Schizophrenia and Lung Cancer Disparities: The Role Clinicians Play in Lung Cancer Screening and Access to Smoking Cessation. Presented at the Massachusetts General Hospital’s 1st Annual Community and Public Psychiatric Symposium, 2015, Boston, MA. (Received award for best poster presented at symposium) 2. Fields LE, Corveleyn AE, Pirl WF, Park JA, Kotagiri N, Hagan TL, and Irwin KE. Tailoring Research Design for Patients with Severe Mental Illness and Cancer. Presented at the American Psychosocial Oncology Society’s 14th Annual Conference, 2017, Orlando, FL (Commendation for best student poster presented at conference) 3. Corveleyn AE, Fields LE, Greer JA, Pirl WF, Park ER, and Irwin KE. Proactive Psychiatry Consultation and Case Management for Patients with Cancer and Serious Mental Illness and their Caregivers: A Pilot Study. Presented at the American Psychosocial Oncology Society’s 14th Annual Conference, 2017, Orlando, Florida. 4. Corveleyn AE, Park ER, Greer JA, Callaway C, and Irwin KE. Exploring the Needs of Caregivers for Patients with Serious Mental Illness. Presented at the American Psychosocial Oncology Society’s 15th Annual Conference, 2018, Tucson, Arizona. 5. Irwin KE, Hurley, M, Shin JA, Park ER, Greer JA, Brown J, Taylor JB, Pirl WF. Disruptions in Breast Cancer Care: Comparing Patients with Schizophrenia and Matched Controls. Narrative Report

Introduction I am a psychiatrist specializing in the care of adults with cancer and serious mental illness (SMI), particularly schizophrenia. After completing internal medicine internship and adult psychiatry residency at Massachusetts General Hospital and McLean Hospital in 2012, I joined the faculty at MGH and HMS, where I provide clinical care, supervise and teach trainees, and conduct research on disparities in cancer care and mortality for patients with SMI. 16

Area of Excellence – Clinical Expertise and Innovation My clinical interests and expertise center on cancer and SMI. I receive referrals from colleagues locally and regionally, with a focus on patients with SMI and cancer, clozapine, and challenges accessing care. In 2015, I founded the Collaborative Care and Community Engagement Program, a clinical and research initiative dedicated to achieving equity in cancer care for patients with SMI. I developed an innovative model of integrated mental health and cancer care delivery, successfully piloted this model, and received funding for the first randomized trial of an intervention for patients with SMI at cancer diagnosis. Our work has been highlighted in the New England Journal of Medicine and led to seed funding from the MGH Department of Psychiatry and Cancer Center. I have experience integrating mental health and cancer care in academic and community settings and consult to the Department of Mental Health. I have chaired symposia nationally and internationally and given grand rounds on cancer care and SMI. Teaching I have taught and supervised medical students, residents, and fellows since joining the HMS faculty. I teach a schizophrenia seminar monthly for medical students, supervise a social worker and nurse practitioner, and teach psycho-oncology to oncology fellows and psychiatry residents. Each week, I supervise a PGY-2 resident in community psychiatry to increase expertise with clozapine and public mental health and provide psychotherapy supervision to a PGY-3 resident. I also teach my research team including a research coordinator, social worker, and interns. I have mentored my research coordinators as they have produced independent research and transitioned to medical school.

Supporting Activity – Investigation Since medical school, I have conducted clinical research on psycho-oncology. Since 2012, I have focused my research on disparities in cancer care for people with SMI. I have received funding from the HMS Dupont-Warren Fellowship, the American Cancer Society, the Harvard Risk Management Foundation, and the Department of Mental Health. We are currently conducting the first randomized trial of an intervention targeting patients with SMI at cancer diagnosis. Additionally, I received a Patient-Centered Outcomes Research Institute Engagement Award to create a cancer and mental health collaborative to build capacity for patient-centered research at the intersection of cancer and mental health. I was funded by the NIH/NCI Program in Cancer Outcomes Research Training to complete a master’s degree at the Harvard School of Public Health to expand my knowledge of quantitative research methods. I recently received an NCI-supported Career Development K08 Award to support conducting the first randomized trial for people with serious mental illness at the time of cancer diagnosis. My research has been recognized by the NIH Loan Repayment Award, the MGH Cancer Center’s One Hundred Award, and the Academy of Psychosomatic Medicine. I have presented my research locally, regionally, and nationally and published in high impact journals including the Journal of Clinical Oncology.

Supporting Activity – Education of Patients and Service to the Community For 6 years, I was the medical director of the Clozapine Program and continue to participate in the Public and Community Psychiatry steering committee and committees focused on behavioral health integration. I founded and lead an annual symposium that brings together 200 patients, caregivers, and advocates with clinicians and researchers committed to decreasing disparities in cancer care for people affected by mental illness. Additionally, with the support of the Trefler Foundation, I lead an initiative to increase access to cancer care for patients with SMI in the community and conduct educational workshops for community mental health staff.

Summary I have dedicated myself to delivering excellent clinical care while conducting health services research, teaching, and engaging in clinical innovation. Through these activities at the local, regional, and national levels, service to the community and involvement with academic and professional societies and the public

17 sector, I have sought to improve the care of underserved populations experiencing premature cancer mortality and to expand knowledge in our field.

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