Washington University School of Medicine Digital Commons@Becker Open Access Publications 2007 Causing and curing infantile esotropia in primates: The oler of decorrelated binocular input (an American Ophthalmological Society thesis) Lawrence Tychsen Washington University School of Medicine in St. Louis Follow this and additional works at: https://digitalcommons.wustl.edu/open_access_pubs Recommended Citation Tychsen, Lawrence, ,"Causing and curing infantile esotropia in primates: The or le of decorrelated binocular input (an American Ophthalmological Society thesis)." Transactions of the American Ophthalmological Society.105,. 564-593. (2007). https://digitalcommons.wustl.edu/open_access_pubs/3298 This Open Access Publication is brought to you for free and open access by Digital Commons@Becker. It has been accepted for inclusion in Open Access Publications by an authorized administrator of Digital Commons@Becker. For more information, please contact
[email protected]. CAUSING AND CURING INFANTILE ESOTROPIA IN PRIMATES: THE ROLE OF DECORRELATED BINOCULAR INPUT (AN AMERICAN OPHTHALMOLOGICAL SOCIETY THESIS) BY Lawrence Tychsen, MD ABSTRACT Purpose: Human infants at greatest risk for esotropia are those who suffer cerebral insults that could decorrelate signals from the 2 eyes during an early critical period of binocular, visuomotor development. The author reared normal infant monkeys, under conditions of binocular decorrelation, to determine if this alone was sufficient to cause esotropia and associated behavioral as well as neuroanatomic deficits. Methods: Binocular decorrelation was imposed using prism-goggles for durations of 3 to 24 weeks (in 6 experimental, 2 control monkeys). Behavioral recordings were obtained, followed by neuroanatomic analysis of ocular dominance columns and binocular, horizontal connections in the striate visual cortex (area V1).