Growth Hormone (GH) Receptor C.1319 G>T Polymorphism
0031-3998/07/6206-0735 PEDIATRIC RESEARCH Vol. 62, No. 6, 2007 Copyright © 2007 International Pediatric Research Foundation, Inc. Printed in U.S.A. Growth Hormone (GH) Receptor C.1319 G>T Polymorphism, But Not Exon 3 Retention or Deletion Is Associated With Better First-Year Growth Response to GH Therapy in Patients With GH Deficiency LEI WAN, WEI-CHENG CHEN, YUHSIN TSAI, YU-TSUN KAO, YAO-YUAN HSIEH, CHENG-CHUN LEE, CHANG-HAI TSAI, CHIH-PING CHEN, AND FUU JEN TSAI Department of Medical Genetics and Medical Research [L.W., W.-C.C., C.-C.L., C.-H.T., F.J.T.], Graduate Institute of Chinese Medical Science [L.W., Y.T., F.J.T.], Department of Obstetrics and Gynecology [Y.-Y.H.], China Medical University Hospital, Taichung 404, Taiwan; Department of Biotechnology and Bioinformatics [L.W., C.-H.T., F.J.T.], Asia University, Taichung 413, Taiwan; Department of Obstetrics and Gynecology [C.-P.C.], Mackay Memorial Hospital, Taipei 104, Taiwan ABSTRACT: We investigated possible influences of single nucleo- activated kinase 2 (JAK2). These molecules serve in signal tide polymorphisms (SNPs) on first-year growth velocity in response transduction by phosphorylating signal transducers and acti- to growth hormone (GH) therapy in GH-deficient (GHD) children. vators of transcription-5 (1). Signal transducers and activators We recruited a total of 154 GHD prepubertal children who had of transcription (STATs) then induce the transcription of undergone GH therapy for 1 y. To exclude the possibility that the insulinlike growth factor (IGF)-I and IGF-II and modulation genotype/allele variants influenced the height of GHD patients, we of the expression of other genes.
[Show full text]