DOCSLIB.ORG

BIOTECHNOLOGY Presented by America’S Biopharmaceutical Research Companies

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
BIOTECHNOLOGY Presented by America’S Biopharmaceutical Research Companies 2011 REPORT 2011 Medicines in Development BIOTECHNOLOGY presented by america’s biopharmaceutical research companies Biotechnology Research Promises to Bolster the Future of Medicine with More Than 900 Medicines and Vaccines in Development In the human body there are Biotechnology Medicines 12 trillion cells, in Development 200,000 proteins and 25,000 genes 300 298 America’s biopharmaceutical research compa- The biotechnology medicines now in develop- nies are using biotechnology to develop 901 ment make use of these and other state-of- medicines and vaccines targeting more than the-art approaches. For example: 100 diseases. Biotechnology medicines are developed through biological processes using $JHQHWLFDOO\PRGL¿HGYLUXVEDVHG living cells or organisms, rather than the tra- vaccine to treat melanoma. ditional chemical synthesis approach. These $PRQRFORQDODQWLERG\IRUWKHWUHDWPHQW medicines in development are either in human of cancer and asthma. clinical trials or under review by the U.S. Food and Drug Administration. $QDQWLVHQVHPHGLFLQHIRUWKHWUHDWPHQW of cancer. Biotechnology medicines use many different $UHFRPELQDQWIXVLRQSURWHLQWRWUHDW 78 cutting-edge approaches to treat disease. A age-related macular degeneration. 64 monoclonal antibody is a laboratory-made 50 version of the naturally occurring immune These are only a few examples of the new system protein that binds to and neutralizes ways America’s biopharmaceutical research foreign invaders. Interferons are proteins that companies are attacking disease through bio- 23 interfere with the ability of a cell to reproduce. technology. The 901 biotechnology medicines Antisense drugs are medicines that interfere and vaccines in development promise to push with the communication process that tells a the frontiers of science and potentially bring e y cell to produce an unwanted protein. Nano- more and better treatments to patients. technology is now being used in biotechnology vaccines antisens cell therapy as drug-delivery systems, new treatments, and gene therap diagnostics. recombinant proteins monoclonal antibodies Biotechnology Medicines in Development Biotechnology Medicines in Development—by Therapeutic Category Autoimmune Disorders 69 Blood Disorders 32 Cancer/Related Conditions 352 Cardiovascular Disease 59 Diabetes/Related Conditions 24 Digestive Disorders 27 Eye Conditions 20 Genetic Disorders 19 Growth Disorders 5 HIV Infection 39 Infectious Diseases 188 Musculoskeletal Disorders 22 Neurologic Disorders 44 Respiratory Disorders 40 Skin Disorders 28 Transplantation 18 Other Diseases 36 Note: Some medicines are listed in more than one category. Biotechnology Medicines in Development—by Product Category Antisense 23 Cell Therapy 64 Gene Therapy 50 Growth Factors 10 Interferons 20 Monoclonal Antibodies (mAb) 300 Recombinant Hormones/Proteins 78 RNA Interference 13 Vaccines 298 Other 45 2 Medicines in Development Biotechnology 2011 Biotechnology Medicines in Development AUTOIMMUNE DISORDERS Product Name Sponsor Product Indication Development Phase* Category A623 Anthera Pharmaceuticals peptide systemic lupus erythematosus Phase II San Mateo, CA fusion (SLE) (650) 931-8868 protein Actemra® Genentech mAb rheumatoid arthritis Phase III tocilizumab South San Francisco, CA (early-stage disease), (800) 626-3553 ankylosing spondylitis AGS-009 Argos Therapeutics mAb SLE Phase I Durham, NC (919) 287-6300 AMG 108 Amgen mAb rheumatoid arthritis Phase II completed Thousand Oaks, CA (800) 772-6436 AMG 557 Amgen mAb SLE Phase I Thousand Oaks, CA (800) 772-6436 AMG 811 Amgen mAb discoid lupus erythematosus, Phase I Thousand Oaks, CA SLE (800) 772-6436 Ampligen® Hemispherx Biopharma RNA product chronic fatigue syndrome application submitted rintatolimid Philadelphia, PA (215) 988-0080 (Orphan Drug) anti-IL6 Bristol-Myers Squibb mAb rheumatoid arthritis Phase II (BMS-945429) Princeton, NJ (800) 332-2056 Alder Biopharmaceuticals (425) 205-2900 Bothell, WA anti-LT alpha Genentech mAb rheumatoid arthritis Phase II (RG7416) South San Francisco, CA (800) 626-3553 anti-TWEAK Biogen Idec mAb rheumatoid arthritis Phase I completed (BIIB 023) Weston, MA (781) 464-2000 ------------------------------------------------ -------------------------------- lupus nephritis Phase I (781) 464-2000 ARX424 Ambrx interferon multiple sclerosis Phase I (PEGylated interferon La Jolla, CA (858) 875-2400 beta-1a) EMD Serono (800) 298-8088 Rockland, MA Arzerra® GlaxoSmithKline mAb rheumatoid arthritis Phase II ofatumumab Rsch. Triangle Park, NC (intravenous) (888) 825-5249 (see also cancer) ------------------------------------------------ --------------------------------- rheumatoid arthritis Phase II (subcutaneous) (888) 825-5249 )RUPRUHLQIRUPDWLRQDERXWDVSHFL¿FPHGLFLQHLQWKHUHSRUWSOHDVHFDOOWKHWHOHSKRQHQXPEHUOLVWHG Medicines in Development Biotechnology 2011 3 Biotechnology Medicines in Development AUTOIMMUNE DISORDERS Product Name Sponsor Product Indication Development Phase Category atacicept EMD Serono recombinant SLE Phase III (TACI-lg) Rockland, MA fusion (800) 283-8088 Zymogenetics protein (206) 442-6000 Seattle, WA ------------------------------------------------ --------------------------------- lupus nephritis Phase I (800) 283-8088 (206) 442-6000 AZ01 Allozyne interferon multiple sclerosis Phase I (peginterferon beta) Seattle, WA (206) 518-5700 BAFF antibody Eli Lilly mAb rheumatoid arthritis, SLE Phase III (tabalumab) Indianapolis, IN (see also cancer, other) (800) 545-5979 ------------------------------------------------ --------------------------------- multiple sclerosis Phase II (800) 545-5979 baminercept Biogen Idec recombinant multiple sclerosis Phase I/II Weston, MA fusion (781) 464-2000 protein Benlysta® GlaxoSmithKline mAb SLE Phase II belimumab Rsch. Triangle Park, NC (see also blood, transplantation) (888) 825-5249 (subcutaneous) Human Genome Sciences (301) 309-8504 Rockville, MD BHT-3009 Bayhill Therapeutics DNA multiple sclerosis Phase II completed Palo Alto, CA vaccine (650) 320-2800 BIIB 017 Biogen Idec interferon relapsing multiple sclerosis Phase III (PEG-interferon Weston, MA (Fast Track) (781) 464-2000 beta-1a) BT-061 Abbott Laboratories mAb rheumatoid arthritis Phase II Abbott Park, IL (see also skin) (847) 937-6100 Biotest www.biotest.de Dreieich, Germany CAM 3001 AstraZeneca mAb rheumatoid arthritis Phase II (mavrilimumab) Wilmington, DE (800) 236-9933 CSL (301) 398-0000 Victoria, Australia MedImmune Gaithersburg, MD Campath® Genzyme mAb relapsing-remitting multiple Phase III alemtuzumab Cambridge, MA sclerosis (617) 679-2000 (intravenous) (Fast Track) (see also cancer, transplantation) 4 Medicines in Development Biotechnology 2011 Biotechnology Medicines in Development AUTOIMMUNE DISORDERS Product Name Sponsor Product Indication Development Phase Category CNTO-136 Janssen Biotech mAb lupus nephritis, rheumatoid arthritis Phase II (sirukumab) Horsham, PA (800) 526-7736 daclizumab Biogen Idec mAb multiple sclerosis—relapsing forms Phase III Weston, MA (781) 464-2000 epratuzumab Immunomedics mAb SLE Phase III Morris Plains, NJ (Fast Track) (973) 605-8200 UCB (see also cancer) Smyrna, GA fezakinumab 3¿]HU mAb rheumatoid arthritis Phase II (ILV-094) New York, NY (see also skin) (860) 732-5156 GBR-500 Glenmark Pharmaceuticals mAb multiple sclerosis Phase I Mumbai, India (see also digestive) gevokizumab XOMA mAb Behcet’s syndrome, Phase II (Orphan Drug) Berkeley, CA rheumatoid arthritis (510) 204-7200 (see also cardiovascular, diabetes) GSK315234 GlaxoSmithKline mAb rheumatoid arthritis Phase II Rsch. Triangle Park, NC (888) 825-5249 GSK1223249 GlaxoSmithKline mAb multiple sclerosis Phase I Rsch. Triangle Park, NC (see also neurologic) (888) 825-5249 Humira® Abbott Laboratories mAb rheumatoid arthritis Phase III adalimumab Abbott Park, IL (combination therapy) (847) 937-6100 (see also digestive, other) IL-17 antibody Eli Lilly mAb rheumatoid arthritis Phase II (ixekizumab) Indianapolis, IN (see also skin) (800) 545-5979 Ilaris® Novartis Pharmaceuticals mAb systemic juvenile idiopathic arthritis Phase III canakinumab East Hanover, NJ (see also cardiovascular, diabetes, (888) 669-6682 (Orphan Drug) musculoskeletal, respiratory) interferon beta-1-a EMD Serono interferon multiple sclerosis Phase I extended release Rockland, MA (800) 283-8088 Flamel Technologies Cedex, France Medicines in Development Biotechnology 2011 5 Biotechnology Medicines in Development AUTOIMMUNE DISORDERS Product Name Sponsor Product Indication Development Phase Category KB003 KaloBios Pharmaceuticals mAb rheumatoid arthritis Phase II Palo Alto, CA (650) 843-1897 MEDI-545 AstraZeneca mAb SLE Phase II (sifalimumab) Wilmington, DE (see also other) (800) 236-9933 Medarex (609) 430-2880 Princeton, NJ (301) 398-0000 MedImmune Gaithersburg, MD MEDI-546 AstraZeneca mAb scleroderma Phase I (anti-IFNalphaR mAb) Wilmington, DE (800) 236-9933 Medarex (301) 298-0000 Princeton, NJ MedImmune Gaithersburg, MD MEDI-551 AstraZeneca mAb scleroderma Phase I (anti-CD19 mAb) Wilmington, DE (see also cancer) (800) 236-9933 MedImmune (301) 298-0000 Gaithersburg, MD MEDI-570 AstraZeneca mAb SLE Phase I (anti-ICOS mAb) Wilmington, DE (800) 236-9933 MedImmune (301) 298-0000 Gaithersburg, MD NN8209 Novo Nordisk mAb rheumatoid arthritis Phase II (anti-C5aR) Princeton, NJ (609) 987-5800 NN8226 Novo Nordisk mAb rheumatoid arthritis Phase II (anti-IL-20 antibody) Princeton, NJ (609) 987-5800 NN8555 Novo Nordisk mAb rheumatoid arthritis Phase II Princeton, NJ (see also digestive) (609) 987-5800 NN8828 Novo Nordisk mAb rheumatoid arthritis Phase I (anti-IL-21
Load more

Recommended publications
  • BIOWORLD TODAY Inquiry
    BIOWORLDTM TODAY THE DAILY BIOPHARMACEUTICAL NEWS SOURCE JUNE 30 , 2016 BIOTECH’S MOST RESPECTED NEWS SOURCE FOR MORE THAN 20 YEARS VOLUME 27, NO. 126 LIPID JAM NOT OVER EASILY STOPPED FOR FUTILITY Waffle house? FDA Galena Biopharma implodes as PRESENT review fidgets endpoint, puts cancer vaccine Neuvax future in doubt outcome details; By Jennifer Boggs, Managing Editor Esperion grilled on holdup With the bulk of Galena Biopharma Inc.’s value riding on cancer vaccine Neuvax By Randy Osborne, Staff Writer (nelipepimut-S), the firm’s shares predictably plunged to a new 52-week low Wednesday as an independent data monitoring committee (IDMC) recommended the Analysts had plenty of questions but PRESENT phase III study in breast cancer be stopped for futility following a planned Esperion Therapeutics Inc. offered few interim analysis. But it’s the troubling language in the IDMC’s letter, suggesting the answers regarding the FDA’s stalling on placebo arm might actually have bested the treatment arm, that could signal the end oral, once-daily bempedoic acid (ETC- of the road for Neuvax. 1002) for lipid lowering, after the agency See Galena, page 3 See Esperion, page 4 CHINA DEALS AND M&A IN THE CLINIC Pfizer invests in Asia Merck strikes cancer SUPER ‘NOVA’ with $350M biotech vaccines deal with Tesaro shares blast plant in Hangzhou Moderna, delivering off as niraparib hits By Haky Moon, Staff Writer $200M up front PFS in ovarian cancer HONG KONG – China’s economy may By Michael Fitzhugh, Staff Writer By Marie Powers, News Editor be slowing down, but multinationals Findings from the phase III NOVA trial are positioning themselves to leverage Cancer vaccines tailored to fit tumor- specific profiles are at the heart of a new of niraparib in women with recurrent it as best they can while navigating a ovarian cancer blasted shares of still-complex regulatory environment.
    [Show full text]
  • Initiation of Francis Trial
    August 25‚ 2008 ANTHERA PHARMACEUTICALS ADVANCES GLOBAL DEVELOPMENT STRATEGY FOR VARESPLADIB IN PATIENTS WITH ACUTE CORONARY SYNDROME WITH THE INITIATION OF FRANCIS TRIAL SAN MATEO, CA – August 25, 2008 – Anthera Pharmaceuticals Inc., a privately held biopharmaceutical company developing anti-inflammatory drugs, today announced the initiation of the FRANCIS (Fewer Recurrent Acute coronary events with Near-term Cardiovascular Inflammation Suppression) clinical trial designed to examine the impact of varespladib when administered to patients within 96 hours of an Acute Coronary Syndrome (ACS) event. The FRANCIS trial is designed to assess the impact of oral varespladib on known biological markers of cardiovascular risk. It will enroll up to 500 patients that will be treated for a minimum of six months. The study will be conducted at sites in North America and Europe. FRANCIS will provide insight into the prevention of secondary Major Adverse Cardiovascular Events (MACE) over the duration of the trial. In this study, MACE is defined as a composite endpoint consisting of cardiovascular death, non-fatal stroke, non-fatal myocardial infarction, unstable angina, and a subset of revascularization following the initial event. During the course of the study, patients will receive therapeutic standard of care in addition to high dose Lipitor ® (atorvastatin). In previous clinical trials, varespladib, a potent and highly selective inhibitor of secretory phospholipase A 2 (sPLA 2), has demonstrated marked improvements in independent markers of cardiovascular risk including, a near complete suppression of the target enzyme sPLA 2, a clinically meaningful and statistically significant reduction in “bad” LDL cholesterol, and a reduction in C-reactive protein, a known marker of inflammation.
    [Show full text]
  • Tetraphase Pharmaceuticals, Inc
    WBB Securities, LLC Steve Brozak, DMH [email protected] (908) 518-7610 Tetraphase Pharmaceuticals, Inc. (NasdaqGS: TTPH) Initiating Coverage Initiating Coverage with a Speculative Buy Rating February 22, 2018 and a 12-Month Price Target of $6.00 Tetraphase Prepares for Commercialization of a Needed Antibiotic Tetraphase Pharmaceuticals, Inc. (TTPH) is Current Price $2.20 a clinical stage pharmaceutical company, 12 Month Target Price $6.00 with eravacycline as its lead candidate. It is a novel tetracycline-derived antibiotic to 12-Month Trading Range $2.05-$9.93 treat resistant and multidrug-resistant Market Capitalization (Mil) $113.50 infections, including multidrug-resistant Shares Outstanding (Mil) 51.59 Gram-negative infections. Following Avg. Daily Volume 872,642 successful IGNITE1 and IGNITE4 Phase 3 L.T. Debt (Mil) 0.00 trials in complicated intra-abdominal infections (cIAI), a New Drug Application Dividend/Yield N/A (NDA) was filed with the FDA and a Book Value P/S $2.92 Marketing Authorisation Application (MAA) was submitted to the EMA for IV NASDAQ Composite 7,218.23 eravacycline. S&P 500 2,701.33 Historical Performance and Disclosures on Page 10 - 11 Two days ago, TTPH announced an exclusive Source: QUODD+ licensing agreement with Everest Medicines Limited, a C-bridge Capital-backed biopharmaceutical company based in China, to develop and commercialize eravacycline in mainland China, Taiwan, Hong Kong, Macau, South Korea, and Singapore (known as the Territories). Tetraphase will receive an initial upfront payment of $7.0 million and may receive clinical and regulatory milestones of up to $16.5 million as well as a maximum of $20.0 million via achieving annual sales milestones.
    [Show full text]
  • Print PDF Opens in a New Window
    CADTH ISSUES IN EMERGING HEALTH TECHNOLOGIES Informing Decisions About New Health Technologies Issue July 173 2018 Monoclonal Antibodies for Osteoarthritis of the Hip or Knee Image courtesy of iStock CADTH ISSUES IN EMERGING HEALTH TECHNOLOGIES 1 Authors: Sirjana Pant, Ke Xin Li, Melissa Severn Cite As: Monoclonal Antibodies for Osteoarthritis of the Hip or Knee. Ottawa: CADTH; 2018. (CADTH issues in emerging health technologies; issue 173). Acknowledgments: CADTH would like to acknowledge the contribution of Dr. Tom Appleton, MD, PhD, FRCPC, Assistant Professor, Rheumatologist; Department of Medicine, Department of Physiology and Pharmacology, The University of Western Ontario; Clinician Scientist, Lawson Health Research Institute; The Rheumatology Centre, St. Joseph’s Health Care London; for his review of the draft version of this bulletin. ISSN: 1488-6324 (online) Disclaimer: The information in this document is intended to help Canadian health care decision-makers, health care professionals, health systems leaders, and policy- makers make well-informed decisions and thereby improve the quality of health care services. While patients and others may access this document, the document is made available for informational purposes only and no representations or warranties are made with respect to its fitness for any particular purpose. The information in this document should not be used as a substitute for professional medical advice or as a substitute for the application of clinical judgment in respect of the care of a particular patient or other professional judgment in any decision-making process. The Canadian Agency for Drugs and Technologies in Health (CADTH) does not endorse any information, drugs, therapies, treatments, products, processes, or services.
    [Show full text]
  • The Top 100 November, 2016 a List of Stocks Topping Our Custom 'Torpedo’ Screen
    The Top 100 November, 2016 A list of stocks topping our custom 'torpedo’ screen. Updated monthly. GPRO GoPro, Inc. Class A Consumer Discretionary TSLA Tesla Motors, Inc. Consumer Discretionary UA Under Armour, Inc. Class A Consumer Discretionary CRC California Resources Corp Energy CRZO Carrizo Oil & Gas, Inc. Energy CWEI Clayton Williams Energy, Inc. Energy FANG Diamondback Energy, Inc. Energy GST Gastar Exploration, Inc. Energy MPLX MPLX LP Energy RSPP RSP Permian, Inc. Energy SLCA U.S. Silica Holdings, Inc. Energy AAC AAC Holdings, Inc. Health Care ABEO Abeona Therapeutics, Inc. Health Care ACAD ACADIA Pharmaceuticals Inc. Health Care ADMP Adamis Pharmaceuticals Corporation Health Care ADMS Adamas Pharmaceuticals, Inc. Health Care ADXS Advaxis, Inc. Health Care AIMT Aimmune Therapeutics Inc Health Care AKBA Akebia Therapeutics, Inc. Health Care ALDR Alder Biopharmaceuticals, Inc. Health Care ARDM Aradigm Corporation Health Care ARDX Ardelyx, Inc. Health Care ARLZ Aralez Pharmaceuticals Inc. Health Care ATRA Atara Biotherapeutics Inc Health Care BCRX BioCryst Pharmaceuticals, Inc. Health Care BLUE bluebird bio, Inc. Health Care CARA Cara Therapeutics Inc Health Care CDNA CareDx, Inc. Health Care CEMP Cempra, Inc. Health Care CERS Cerus Corporation Health Care CFMS ConforMIS Inc Health Care CLVS Clovis Oncology, Inc. Health Care COLL Collegium Pharmaceutical, Inc. Health Care CORI Corium International, Inc. Health Care CRMD CorMedix Inc. Health Care CSU Capital Senior Living Corporation Health Care DERM Dermira Inc Health Care DVAX Dynavax Technologies Corporation Health Care DXCM DexCom, Inc. Health Care EPZM Epizyme, Inc. Health Care FOLD Amicus Therapeutics, Inc. Health Care HRTX Heron Therapeutics Inc Health Care ICPT Intercept Pharmaceuticals, Inc.
    [Show full text]
  • Comment Letter
    July 23, 2008 Subject: Follow-up on July 22 Meeting Dr. Sirri et al.: I thank you for meeting with Ken Salomon, John Welborn and me yesterday afternoon to discuss Reg SHO, naked short selling and the SEC's recent emergency order. As a follow-up, I want to emphasize the following points: 1. OSTK continues to believe that it is critical that the SEC extend the pre-borrow requirement of the emergency order to the entire market, not just the 19 select companies. OSTK requests that the SEC promptly undertake swift rulemaking so that this protection applies fairly across the market. 2. OSTK continues to support the prompt and full elimination of the option market maker exception, an exception that swallows up the good intentions of Reg SHO. During yesterday's meeting, we discussed the relationship between the markets for equities and their corresponding derivatives (including listed options). You stated that options market makers enjoy an exception from the Reg SHO requirement that they locate and/or deliver shares when hedging against options positions. I am not sure that I would read Reg SHO to say that. However, under your theory, if an options market maker sells a put with a 6- month expiration, then that same market maker has the legal right to naked short and fail to deliver an equivalent amount of the underlying equity (leaving the option market maker "delta neutral”) for six months. This exception is unnecessary and open to abuse/manipulation, particularly with the married puts that often occur in Reg SHO threshold securities.
    [Show full text]
  • Drug Delivery Technology Y
    * DDT Nov-Dec 2007 Working 11/9/07 2:29 PM Page 1 November/December 2007 Vol 7 No 10 IN THIS ISSUE Company Profiles 12 Drug Delivery Technologies 58 Excipients, Polymers, Liposomes & Lipids 78 Contract Pharmaceutical & Biological Development Services 83 Machinery & Laboratory Equipment and Software 96 Technology Showcase 102 The science & business of specialty pharma, biotechnology, and drug delivery www.drugdeliverytech.com * DDT Nov-Dec 2007 Working 11/9/07 2:39 PM Page 2 * DDT Nov-Dec 2007 Working 11/9/07 2:40 PM Page 3 * DDT Nov-Dec 2007 Working 11/9/07 2:40 PM Page 4 November/December 2007 Vol 7 No 10 PUBLISHER/PRESIDENT Ralph Vitaro EXECUTIVE EDITORIAL DIRECTOR Dan Marino, MSc [email protected] CREATIVE DIRECTOR Shalamar Q. Eagel CONTROLLER Debbie Carrillo CONTRIBUTING EDITORS Cindy H. Dubin Debra Bingham Jason McKinnie TECHNICAL OPERATIONS Mark Newland EDITORIAL SUPPORT Nicholas D. Vitaro ADMINISTRATIVE SUPPORT Kathleen Kenny Corporate/Editorial Office 219 Changebridge Road, Montville, NJ 07045 Tel: (973)299-1200 Fax: (973) 299-7937 www.drugdeliverytech.com Advertising Sales Offices East & Midwest Victoria Geis - Account Executive Coming in 2008 Cheryl S. Stratos - Account Executive 103 Oronoco Street, Suite 200 Alexandria, VA 22314 Tel: (703) 212-7735 Drug Delivery Weekly & Fax: (703) 548-3733 E-mail: [email protected] Specialty Pharma News E-mail: [email protected] West Coast Warren De Graff Western Regional Manager 818 5th Avenue, Suite 301 San Rafael, CA 94901 Tel: (415) 721-0644 Fax: (415) 721-0665 E-mail: [email protected] 0 The weekly electronic newsletter from the publishers of Drug 1 International o N Delivery Technology and Specialty Pharma will provide over 12,000 Ralph Vitaro 7 219 Changebridge Road l o subscribers with the latest news of business deals, alliances, and V Montville, NJ 07045 Tel: (973) 299-1200 7 technology breakthroughs from the pharmaceutical, specialty 0 Fax: (973) 299-7937 0 2 pharmaceutical, drug delivery, and biotechnology industries.
    [Show full text]
  • Tanibirumab (CUI C3490677) Add to Cart
    5/17/2018 NCI Metathesaurus Contains Exact Match Begins With Name Code Property Relationship Source ALL Advanced Search NCIm Version: 201706 Version 2.8 (using LexEVS 6.5) Home | NCIt Hierarchy | Sources | Help Suggest changes to this concept Tanibirumab (CUI C3490677) Add to Cart Table of Contents Terms & Properties Synonym Details Relationships By Source Terms & Properties Concept Unique Identifier (CUI): C3490677 NCI Thesaurus Code: C102877 (see NCI Thesaurus info) Semantic Type: Immunologic Factor Semantic Type: Amino Acid, Peptide, or Protein Semantic Type: Pharmacologic Substance NCIt Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells, while VEGF is overexpressed in many tumors and is correlated to tumor progression. PDQ Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor
    [Show full text]
  • Bristol-Myers Squibb 2019 Annual Report
    We’re inspired by a single vision: 2019 ANNUAL REPORT Our Mission To discover, develop and deliver innovative medicines that help patients prevail over serious diseases Our Vision To be the world's leading biopharma company that transforms patients' lives through science The patient stories shared in this Annual Report depict individual patient responses to our medicines or investigational compounds and are not representative of all patient responses. In addition, there is no guarantee that potential drugs or indications still in development will receive regulatory approval. Bristol Myers Squibb 2019 Annual Report Myers Bristol Made Strong® is a registered mark of the Made Strong organization. Used with permission. Letter from the Chairman and CEO At Bristol Myers Squibb, we are inspired by our mission – to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. Every day, we focus on innovations that drive meaningful breakthroughs so we can bring life-saving medicines to people around the world. 2019 was a transformative year for us. A BIOPHARMA LEADER THE POWER OF FOLLOWING THE SCIENCE The acquisition of Celgene Corporation significantly We start this next chapter at a time when unprecedented advanced our strategy to create a leading biopharma scientific breakthroughs are advancing the treatment company by bringing together the speed and agility of disease as never before. Bristol Myers Squibb is well of a biotech with the global scale and resources of an positioned in scientific hubs of innovation in the U.S. and established pharmaceutical company. Our new company globally, and we collaborate with a broad network of global has strong commercial franchises in oncology, hematology, partners across our disease areas of focus to sustain our immunology and cardiovascular disease, one of the most leadership and continue to transform patient outcomes.
    [Show full text]
  • Progress Report January 2009 – December 2011
    North Carolina State University Professional Science Master’s Program Progress Report January 2009 – December 2011 The Graduate School College of Agriculture & Life Sciences College of Design College of Education College of Engineering College of Humanities & Social Sciences Poole College of Management College of Natural Resources College of Physical & Mathematical Sciences College of Textiles College of Veterinary Medicine First-Year College 1 Greetings From the UNC System PSM Director The Professional Science Master’s (PSM) Program is one of the University of North Carolina (UNC) System’s ways to close the existing skills gap in the workplace. Together with local employers, we design graduate education and training regimens to match employers’ needs. The UNC System has undertaken a collaborative effort to develop these new programs in key areas of importance to North Carolina’s local economies. I am pleased to report that NC State University now offers nine PSM programs. Several new programs are at various planning stages, and numerous new central resources and services are available or under way for these programs. A special milestone in 2010 was the establishment of the PSM Council at NC State University. Members of this group include faculty who direct PSM programs or are planning to offer them in the future. The PSM Council oversees new program development and determines the future strategy for the PSM programs at NC State University. Another important milestone was the award of a new UNC System grant from the Alfred P. Sloan Foundation and support from the UNC General Administration for multiple online tools. I am greatly indebted to the many employers, professors and students who contribute to the collective success of NC State University’s PSM programs.
    [Show full text]
  • February 11-12, 2013 the Waldorf Astoria New York
    February 11-12, 2013 The Waldorf Astoria New York 15th ANNU AL EVENT Now in its fifteenth year, the BIO CEO & Investor Conference is the largest independent investor conference focused on leading publicly-traded biotech companies. The meeting provides a neutral forum where institutional investors, industry analysts, and senior biotechnology executives have the opportunity to shape the future investment landscape of the biotechnology industry. Reasons Top 10 to attend 1 Present your company story to an audience of targeted investors. 2 Hear the Washington perspective on the Affordable Care Act, debt ceiling, and other timely policy developments affecting the industry. 3 Evaluate fresh investment opportunities including compatible, complementary and competitive companies. 4 Learn about the hottest clinical developments and industry catalysts by attending the conference’s therapeutic workshops and business roundtables. 5 Attend fireside chats with CEOs who will share their recent company successes, what keeps the C-suite up at night, and where the industry’s leading companies are headed in 2013. 6 Gain access to BIO’s 1x1 Partnering System for scouting potential deal partners and optimizing your time at the event. 7 Access presentations from more than 140 established public and private biotech companies and non-profit funding organizations, including many you won’t hear from at other investor conferences. 8 Get the pulse on the current and proposed investment trends in biotechnology. 9 Network with peers, investors and potential partners attending the conference. 10 It’s the first NYC biotech conference of the year, kicking off a week of key industry events that you don’t want to miss.
    [Show full text]
  • PIIS0016508516348168(1).Pdf
    Gastroenterology 2016;151:651–659 CLINICAL—LIVER High Efficacy of ABT-493 and ABT-530 Treatment in Patients With HCV Genotype 1 or 3 Infection and Compensated Cirrhosis Edward Gane,1 Fred Poordad,2 Stanley Wang,3 Armen Asatryan,3 Paul Y. Kwo,4 Jacob Lalezari,5 David L. Wyles,6 Tarek Hassanein,7 Humberto Aguilar,8 Benedict Maliakkal,9 Ran Liu,3 Chih-Wei Lin,3 Teresa I. Ng,3 Jens Kort,3 and Federico J. Mensa3 1University of Auckland, Auckland, New Zealand; 2Texas Liver Institute, University of Texas Health Science Center, San Antonio, Texas; 3AbbVie, Inc, North Chicago, Illinois; 4Indiana University School of Medicine, Indianapolis, Indiana; 5Quest Clinical Research, San Francisco, California; 6University of California San Diego, La Jolla, California; 7Southern California GI and Liver Centers and Southern California Research Center, Coronado, California; 8Louisiana Research Center, Shreveport, Louisiana; 9University of Rochester Medical Center, Rochester, New York to liver decompensation, as defined by ascites, jaundice, See Covering the Cover synopsis on page 571; encephalopathy, or variceal bleeding.2 Achievement of a CLINICAL LIVER see editorial on page 587. sustained virologic response (SVR) reduces the risk of hepatic decompensation events, end-stage liver disease, 3–5 BACKGROUND & AIMS: The combination of ABT-493 (NS3/4A hepatocellular carcinoma, and liver-related mortality. protease inhibitor) plus ABT-530 (NS5A inhibitor) has shown Recognizing the need to prevent these complications, the high rates of sustained virologic response at post-treatment American Association for the study of Liver Diseases/ week 12 (SVR12) in noncirrhotic patients infected with hepa- Infectious Disease Society of America, and the European titis C virus (HCV) genotypes (GTs) 1–6.
    [Show full text]