Assessment of Epinephrine and Norepinephrine in Gastric Carcinoma
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Neurotransmitter Resource Guide
NEUROTRANSMITTER RESOURCE GUIDE Science + Insight doctorsdata.com Doctor’s Data, Inc. Neurotransmitter RESOURCE GUIDE Table of Contents Sample Report Sample Report ........................................................................................................................................................................... 1 Analyte Considerations Phenylethylamine (B-phenylethylamine or PEA) ................................................................................................. 1 Tyrosine .......................................................................................................................................................................................... 3 Tyramine ........................................................................................................................................................................................4 Dopamine .....................................................................................................................................................................................6 3, 4-Dihydroxyphenylacetic Acid (DOPAC) ............................................................................................................... 7 3-Methoxytyramine (3-MT) ............................................................................................................................................... 9 Norepinephrine ........................................................................................................................................................................ -
A Case of Mistaken Identity…
Gastroenterology & Hepatology: Open Access Case Report Open Access A case of mistaken identity… Abstract Volume 5 Issue 8 - 2016 Paragangliomas are rare tumors of the autonomic nervous system, which may origin from Marina Morais,1,2 Marinho de Almeida,1,2 virtually any part of the body containing embryonic neural crest tissue. Catarina Eloy,2,3 Renato Bessa Melo,1,2 Luís A 60year-old old female, with a history of resistant hypertension and constitutional Graça,1 J Costa Maia1 symptoms, was hospitalized for acute renal failure. In the investigation, a CT scan revealed 1General Surgery Department, Portugal a 63x54mm hepatic nodule in the caudate lobe. Intraoperatively, the tumor was closely 2University of Porto Medical School, Portugal attached to segment 1, but not depending directly on the hepatic parenchyma or any other 3Instituto de Patologia e Imunologia Molecular da Universidade adjacent structure, and it was resected. Histology reported a paraganglioma. Postoperative do Porto (IPATIMUP), Portugal period was uneventful. Correspondence: J Costa Maia, Sao Joao Medical Center, A potentially functional PG was mistaken for an incidentaloma, due to its location, General Surgery Department, Portugal, interrelated illnesses and unspecific symptoms. PG may mimic primary liver tumors and Email therefore should be a differential diagnosis for tumors in this location. Received: August 29, 2016 | Published: December 30, 2016 Background and hydrochlorothiazide), was admitted to the Internal Medicine Department due to gastroenteritis and dehydration-associated acute Paragangliomas (PG) are rare tumors of the autonomic nervous renal failure (ARF). She reported weight loss (more than 15%), system. Their origin takes part in the neural crest cells, which produce anorexia, asthenia, polydipsia, polyuria and frequent episodes of 1 neuropeptides and catecholamines. -
Urology & Kidney Disease News
CLEVELAND CLINI Urology & Kidney Disease News C Glickman Urological & Kidney Institute A Physician Journal of Developments in Urology and Nephrology Vol. 21 | Winter 2012 G lickman Urological & Kidney I n stitute | Urology & Kidney Disease News | 21 l. V o 2 012 In This Issue: 17 45 58 Robotic Surgery with the Post-Transrectal Ultrasound The ABCDs of Antibiotic Dosing Adjunctive Use of Fluorescent (TRUS)- Guided Prostate Biopsy in Continuous Dialysis Imaging for Prostate Cancer Infection – Importance of Quality and Outcomes Surveillance 60 36 The Potential Role of Stem Cells Determinants of Renal Function 51 in Relief of Urinary Incontinence After Partial Nephrectomy: Molecular Insights into Implications for Surgical Technique Salt-Sensitive Hypertension 72 NextGenSM Home Sperm Banking Kit clevelandclinic.org/glickman 44 56 for Men from Geographically Remote Gene Expression Profiling of Critical Care Nephrology – Testing Sites Seeking Fertility Preservation Prostate Cancer: First Step to the Old and Finding the New Services: An Exciting Development Identifying Best Candidates for Active Surveillance 78224_CCFBCH_Cover_ACG.indd 1 12/12/11 7:37 PM Urology & Kidney Resources for Physicians Resources for Patients Physician Directory Disease News View all Cleveland Clinic staff online at Medical Concierge clevelandclinic.org/staff. For complimentary assistance for out-of-state patients and families, call 800.223.2273, ext. Referring Physician Center Chairman’s Report ....................................................................4 55580, or email [email protected]. For help with service-related issues, information about our News from the Glickman Urological & Kidney Institute clinical specialists and services, details about CME oppor- Global Patient Services tunities, and more, contact the Referring Physician Center Chair Established in Urological Oncology Research ......................5 For complimentary assistance for national at [email protected], or 216.448.0900 or 888.637.0568. -
NORPRAMIN® (Desipramine Hydrochloride Tablets USP)
NORPRAMIN® (desipramine hydrochloride tablets USP) Suicidality and Antidepressant Drugs Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of NORPRAMIN or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. NORPRAMIN is not approved for use in pediatric patients. (See WARNINGS: Clinical Worsening and Suicide Risk, PRECAUTIONS: Information for Patients, and PRECAUTIONS: Pediatric Use.) DESCRIPTION NORPRAMIN® (desipramine hydrochloride USP) is an antidepressant drug of the tricyclic type, and is chemically: 5H-Dibenz[bƒ]azepine-5-propanamine,10,11-dihydro-N-methyl-, monohydrochloride. 1 Reference ID: 3536021 Inactive Ingredients The following inactive ingredients are contained in all dosage strengths: acacia, calcium carbonate, corn starch, D&C Red No. 30 and D&C Yellow No. 10 (except 10 mg and 150 mg), FD&C Blue No. 1 (except 25 mg, 75 mg, and 100 mg), hydrogenated soy oil, iron oxide, light mineral oil, magnesium stearate, mannitol, polyethylene glycol 8000, pregelatinized corn starch, sodium benzoate (except 150 mg), sucrose, talc, titanium dioxide, and other ingredients. -
Biogenic Amine Reference Materials
Biogenic Amine reference materials Epinephrine (adrenaline), Vanillylmandelic acid (VMA) and homovanillic norepinephrine (noradrenaline) and acid (HVA) are end products of catecholamine metabolism. Increased urinary excretion of VMA dopamine are a group of biogenic and HVA is a diagnostic marker for neuroblastoma, amines known as catecholamines. one of the most common solid cancers in early childhood. They are produced mainly by the chromaffin cells in the medulla of the adrenal gland. Under The biogenic amine, serotonin, is a neurotransmitter normal circumstances catecholamines cause in the central nervous system. A number of disorders general physiological changes that prepare the are associated with pathological changes in body for fight-or-flight. However, significantly serotonin concentrations. Serotonin deficiency is raised levels of catecholamines and their primary related to depression, schizophrenia and Parkinson’s metabolites ‘metanephrines’ (metanephrine, disease. Serotonin excess on the other hand is normetanephrine, and 3-methoxytyramine) are attributed to carcinoid tumours. The determination used diagnostically as markers for the presence of of serotonin or its metabolite 5-hydroxyindoleacetic a pheochromocytoma, a neuroendocrine tumor of acid (5-HIAA) is a standard diagnostic test when the adrenal medulla. carcinoid syndrome is suspected. LGC Quality - ISO Guide 34 • GMP/GLP • ISO 9001 • ISO/IEC 17025 • ISO/IEC 17043 Reference materials Product code Description Pack size Epinephrines and metabolites TRC-E588585 (±)-Epinephrine -
Endocrine Abstracts Vol 65
Endocrine Abstracts November 2019 Volume 65 ISSN 1479-6848 (online) Society for Endocrinology BES 2019 11–13 November 2019, Brighton published by Online version available at bioscientifica www.endocrine-abstracts.org Volume 65 Endocrine Abstracts November 2019 Society for Endocrinology BES 2019 11–13 November 2019, Brighton VOLUME EDITORS The abstracts submitted were marked by the Abstract Marking panel, selected by the Programme Organising Committee. Programme Committee D Bassett (Programme Secretary) (London) Laura Matthews (Leeds) Andrew Childs (Programme Co-ordinator) (London) Carla Moran (Cambridge) Nils Krone (Programme Co-ordinator) (Sheffield) Annice Mukherjee (Salford) Helen Simpson (Programme Co-ordinator) (London) Francesca Spiga (Bristol) Davide Calebiro (Birmingham) Jeremy Tomlinson (Oxford) Ben Challis (Cambridge) Jennifer Walsh (Sheffield) Mandy Drake (Edinburgh) Abstract Marking Panel Ramzi Ajjan (Leeds) Neil Gittoes (Birmingham) John Newell-Price (Sheffield) Richard Anderson (Edinburgh) Helena Gleeson (Birmingham) Mark Nixon (Edinburgh) Ruth Andrew (Edinburgh) Philippa Hanson (London) Finbarr O’Harte (Ulster) Weibke Arlt (Birmingham) Martin Hewison (Birmingham) Adrian Park (Cambridge) Mo Aye (Hull) Claire Higham (Manchester) Simon Pearce (Newcastle) Tom Barber (Warwick) Steve Hillier (Edinburgh) Andrew Powlson (Cambridge) Duncan Bassett (London) Andy James (Newcastle) Teresa Rea (Belfast) Roger Brown (Edinburgh) Channa Jayasena (London) Martin Read (Birmingham) Paul Carroll (London) Niki Karavitaki (Oxford) Aled Rees (Cardiff) -
Co-Ingestion of Tricyclic Antidepressants with Selective Norepinephrine Reuptake Inhibitors Overdose in the Emergency Department
Case Report Co-ingestion of tricyclic antidepressants with selective norepinephrine reuptake inhibitors Overdose in the emergency department Jatin Kaicker MD Joanna Bostwick MD CCFP(EM) Case description An 18-year-old female student presents to the emergency department (ED) with a decreased level of consciousness. She was last seen awake the night before, and her parents could not rouse her from sleep that morning. She has a known history of depression, which is treated with an oral 100-mg dose of desvenlafaxine daily and an oral 100-mg dose of amitriptyline once daily at bedtime. There is no history of recent travel, trauma, or ill- EDITor’s kEY POINTS ness. Her parents do not believe she drinks • Having a clinical approach to patients with unknown toxic ingestion is alcohol or uses illicit drugs. Empty bottles imperative. Family physicians must be able to identify and manage patients of desvenlafaxine and amitriptyline were who overdose on multiple antidepressant agents, especially as these found in the patient’s room (each bottle pharmacologic agents are commonly prescribed. held approximately 60 tablets). The patient’s examination findings • Identification of patients with tricyclic antidepressant overdose is reveal a temperature of 36°C, heart rate based on high clinical suspicion and electrocardiogram findings of of 160 beats/min, respiratory rate of QRS widening. Early management should involve sodium bicarbonate. 12 breaths/min, blood pressure of 105/70 mm Hg, and oxygen saturation of • There is a risk of QT prolongation and torsades de pointes for patients 100% on room air. There is no evidence of who overdose on tricyclic antidepressants and have concomitantly ingested selective norepinephrine reuptake inhibitors. -
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanismss
Supplemental Material can be found at: /content/suppl/2020/12/18/73.1.202.DC1.html 1521-0081/73/1/202–277$35.00 https://doi.org/10.1124/pharmrev.120.000056 PHARMACOLOGICAL REVIEWS Pharmacol Rev 73:202–277, January 2021 Copyright © 2020 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license. ASSOCIATE EDITOR: MICHAEL NADER Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanismss Antonio Inserra, Danilo De Gregorio, and Gabriella Gobbi Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, Quebec, Canada Abstract ...................................................................................205 Significance Statement. ..................................................................205 I. Introduction . ..............................................................................205 A. Review Outline ........................................................................205 B. Psychiatric Disorders and the Need for Novel Pharmacotherapies .......................206 C. Psychedelic Compounds as Novel Therapeutics in Psychiatry: Overview and Comparison with Current Available Treatments . .....................................206 D. Classical or Serotonergic Psychedelics versus Nonclassical Psychedelics: Definition ......208 Downloaded from E. Dissociative Anesthetics................................................................209 F. Empathogens-Entactogens . ............................................................209 -
BLOOD TYPE) Methodology: Tube Agglutination BBK Set Up: Daily, As Ordered ABORH BLOOD TYPE 6.0 Ml Whole Blood (Pink) ABORH Report Available: Same Day
LAB OE TEST REFERENCE SPECIMEN ORDER ORDER PROCEDURE RANGE REQUIREMENTS MNEMONIC NAME ABORH GROUP (BLOOD TYPE) Methodology: Tube agglutination BBK Set up: Daily, as ordered ABORH BLOOD TYPE 6.0 mL whole blood (Pink) ABORH Report available: Same day CPT Code: 86900, 86901 ACA or ACLA - See Anti-Cardiolipin Antibodies ACE - see Angiotensin-1 Converting Enzyme ACETAMINOPHEN, SERUM Methodology: Immunoassay 1 mL blood (Gn -Li (PST)) Set up: Daily, as ordered or LAB ACETAMINOPHEN Accompanies report Report available: Same day 1 mL serum (SS) ACET Minimum: 0.5 mL CPT Code: 80329 ACETYLCHOLINE RECEPTOR 1.0 mL serum (SS) BINDING ANTIBODIES (QUEST 206) Minimum: 0.5 mL ACETYLCHOLINE BINDING Methodology: RIA LAB Accompanies report RECEP Set up: Tues-Sat Allow serum to clot at room ACETYL BIND Report available: 1-2 days temperature. Serum should be separated from cells within 1 CPT Code: 83519 hour of collection. ACETYLCHOLINE RECEPTOR BLOCKING ANTIBODIES (QUEST 34459) 1.0 mL serum (SS) centrifuge ACETYLCHOLINE Methodology: RIA with 1 hr of collection LAB Accompanies report BLOCKING RECEP Set up:Mon, Wed, Fri ACETYL BLO Report available: Next day Minimum:0.5 mL CPT Code: 83519 ACETYLCHOLINE RECEPTORMODULATING ANTIBODY (QUEST 26474) 1 mL serum (SS) ACETYLCHOL LAB Methodology: RIA Accompanies report MODULATING RECEP ACETYL MOD Set up: Tue,Thur,Sun Minimum: 0.5 mL Report available: 5 days CPT Code: 83519 ACETYLCHOLINESTERASE, QUALITATIVE, GEL ELECTROPHORESIS (QUEST 185314) This test is automatically performed on all 1.5 mL Amniotic fluid, ROOM Alpha-Fetroprotein -
Written Witness Statement for U.S. Sentencing Commission's Public
STATEMENT OF TERRENCE L. BOOS, PH.D. SECTION CHIEF DRUG AND CHEMICAL EVALUATION SECTION DIVERSION CONTROL DIVISION DRUG ENFORCEMENT ADMINISTRATION and CASSANDRA PRIOLEAU, PH.D. DRUG SCIENCE SPECIALIST DRUG AND CHEMICAL EVALUATION SECTION DIVERSION CONTROL DIVISION DRUG ENFORCEMENT ADMINISTRATION - - - BEFORE THE UNITED STATES SENTENCING COMMISSION - - - HEARING ON SENTENCING POLICY FOR SYNTHETIC DRUGS - - - OCTOBER 4, 2017 WASHINGTON, D.C. 1 Introduction New Psychoactive Substances (NPS) are substances trafficked as alternatives to well- studied controlled substances of abuse. NPS have demonstrated adverse health effects such as paranoia, psychosis, and seizures to name a few. Cathinones, cannabinoids, and fentanyl-related substances are the most common NPS drug classes encountered on the illicit drug market, all with negative consequences for the user to include serious injury and death. Our early experience saw substances being introduced from past research efforts in an attempt to evade controls. This has evolved to NPS manufacturers structurally altering substances at a rapid pace with unknown outcomes to targeting specific user populations. These substances represent an unprecedented level of diversity and consequences. Due to clandestine manufacture and unscrupulous trafficking, the user is at great risk. A misconception exists that these substances carry a lower risk of harm In reality, published reports from law enforcement, emergency room physicians and scientists, accompanied with autopsies from medical examiners, have clearly demonstrated the harmful and potentially deadly consequences of using synthetic cathinones. These substances are introduced in an attempt to circumvent drug controls and the recent flood of NPS remains a challenge for law enforcement and public health. The United Nations Office on Drugs and Crime reported over 700 NPS encountered.1 The manufacturers and traffickers make minor changes in the chemical structure of known substances of abuse and maintain the pharmacological effect. -
Catecholamines and the Hydroxylation of Tyrosine in Synaptosomes Isolated from Rat Brain (DOPA/Tyramine/Dopamine/Norepinephrine/Octopamine) M
Proc. Nat. Acad. Sci. USA Vol. 68, No. 10, pp. 2370-2373, October 1971 Catecholamines and the Hydroxylation of Tyrosine in Synaptosomes Isolated from Rat Brain (DOPA/tyramine/dopamine/norepinephrine/octopamine) M. KAROBATH Psychiatric Research Laboratories, Massachusetts General Hospital, Boston, Mass. 02114 Communicated by Seymour S. Kety, July 16, 1971 ABSTRACT Tyrosine hydroxylase activity of synapto- removing transmitters from an extraneuronal location at the somes isolated from rat brain was examined. A modified synapse, then incubation of synaptosomes with catechol- tritium-displacement assay was used, which allowed the measurement of tyrosine hydroxylase activity without the amines should inhibit the formation of DOPA from tyrosine. addition of either inhibitors of the metabolism of the The experiments demonstrate that tyrosine hydroxylase hydroxylated products or added exogenous cofactor. The activity is affected by catecholamine uptake. The concentra- enzyme activity was strongly inhibited by the addition of tions required to inhibit the synthesis of catechols are in the exogenous catecholamines and 3,4-dihydroxy-L-phenyl- M. alanine. Aromatic amines other than catechols did not range of 10-7 markedly influence tyrosine hydroxylase activity. These MATERIALS AND METHODS in vitro findings support the hypothesis that synthesis of catecholamines is regulated by a mechanism of end- [3,5-H]HifTyrosine (Tracerlab) was purified by column chro- product inhibition at the tyrosine hydroxylase step. matography. Catechol impurities were absorbed on alumina and tritiated water and anions were removed by Synaptosomes are pinched-off nerve endings with relatively columns (8), by non-neuronal elements (1, 2). They absorption on Dowex-50 resin. Tyrosine was eluted from little contamination Dowex-50 with 25 ml of 4 N HCl; after distillation of the eluate contain the enzymes necessary for the synthesis of dopamine (v/v) from tyrosine (3, 4). -
Pharmaceutical Appendix to the Tariff Schedule 2
Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM LIDADRONICUM 63132-38-7 ABAFUNGIN 129639-79-8 ACIDUM SALCAPROZICUM 183990-46-7 ABAMECTIN 65195-55-3 ACIDUM SALCLOBUZICUM 387825-03-8 ABANOQUIL 90402-40-7 ACIFRAN 72420-38-3 ABAPERIDONUM 183849-43-6 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABATACEPTUM 332348-12-6 ACITEMATE 101197-99-3 ABCIXIMAB 143653-53-6 ACITRETIN 55079-83-9 ABECARNIL 111841-85-1 ACIVICIN 42228-92-2 ABETIMUSUM 167362-48-3 ACLANTATE 39633-62-0 ABIRATERONE 154229-19-3 ACLARUBICIN 57576-44-0 ABITESARTAN 137882-98-5 ACLATONIUM NAPADISILATE 55077-30-0 ABLUKAST 96566-25-5 ACODAZOLE 79152-85-5 ABRINEURINUM 178535-93-8 ACOLBIFENUM 182167-02-8 ABUNIDAZOLE 91017-58-2 ACONIAZIDE 13410-86-1 ACADESINE 2627-69-2 ACOTIAMIDUM 185106-16-5 ACAMPROSATE 77337-76-9