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KPNW Specimen Requirements ***Please Hit 'Ctrl'+'F' to Open the 'Find on This Page' Funtion Page 1 of 368 KPNW Specimen Requirements ***Please hit 'Ctrl'+'F' to open the 'Find on this page' funtion. Panel Name Panel Description Preferred Collection/Volume: RED 10 No Gel Barrier Tubes Volume: 1.0 mL Serum Alternative Collection: GRN Li Hep or LAV EDTA Volume: 1.0 mL Plasma TAT: Report available: 5 Days Test Schedule: Saturday Morning Method: Liquid Chromatography/Tandem Mass Spectrometry Test Facility: Quest Diagnostics Nichols Inst San Juan Capistrano 33608 Ortega Highway San Juan Capistrano, CA 92690-6130 Clinical Data: 11-Deoxycortisol (Compound S) is useful in diagnosing patients with 11-beta- hydroxylase deficiency (second leading cause of congenital adrenal hyperplasia) and 11-Deoxycortisol primary (adrenal failure) or secondary (hypothalmic-pituitary ACTH deficiency) adrenal insufficiency. Patient Preparation: An early morning specimen is preferred Specimen Stability: Room Temperature: 4 days Refrigerated: 4 days Frozen: 4 weeks Ship serum frozen or refrigerated Test Code: CHANTILLY T.C.30543 TO SJC TC 30543X Processing: Centrifuge and aliquot into Referred Tests aliquot tube. Note if serum or plasma on specimen. Freeze solid. Transport: Transport frozen on ice. Preferred Collection/Volume: Preserve 24-hour urine with 25 mL of 50% Acetic Acid (preferred) or 30 mL 6N HCl or 1 gram Boric Acid/100 mL (acceptable) during collection. Refrigerate during collection. TAT: Next Day Test Schedule: Monday-Friday Night Method: Colorimetric Test Facility: Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153 17 Ketosteroids Total Pediatric 24 Hr Urine Labeling: Please specify on the request form and on the urine container the patient's age, sex, and (Includes Creatinine the total 24-hour urine volume Ratio) Specimen Stability: Room Temperature: 8 hours Refrigerated: 7 days Frozen: 30 days (-20c) Please specify on the request form and on the urine container the patient's age, sex, and the total 24-hour urine volume. Test Code: Quest TC 2796 Processing: Mix sample well and aliquot. Note on sample total volume and preservative used during collection. Transport: Refrigerate if held. file:///C:/Users/D111011/AppData/Local/Temp/notes6018E4/PinfoPortal_031515.html 4/23/2015 Page 2 of 368 Preferred Collection/Volume: RED 10 No Gel Barrier Tubes Volume: 0.5 mL Serum TAT: 3 Days Test Schedule: Monday-Friday, Sunday Night Method: Liquid Chromatography/Tandem Mass Spectrometry Test Facility: Quest Diagnostics Nichols Inst San Juan Capistrano 33608 Ortega Highway San Juan Capistrano, CA 92690-6130 Clinical Data: 17-Hydroxyprogesterone is elevated in patients with congenital adrenal 17 OH-Progesterone hyperplasia (CAH). CAH is a group of autosomal recessive diseases, characterized by a deficiency of cortisol and an excess of ACTH concentration. 17-Hydroxyprogesterone is also useful in monitoring cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms. Specimen Stability: Room Temperature: 48 Hours Refrigerated: 7 Days Frozen: 2 Years Test Code: SJC TC 17180 Processing: Centrifuge and aliquot into Referred Tests aliquot tube. Transport: Refrigerate if held Preferred Collection/Volume: Preserve 24-hour urine with 25 mL of 50% Acetic Acid (preferred) or 30 mL 6N HCl or 1 gram Boric Acid/100 mL (acceptable) during collection. Preferred Specimen 20 mL 24-Hour Urine TAT: Report available: Next Day Test Schedule: Monday-Friday Night Method: Colorimetric Test Facility: Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153 17- Hydroxycorticosteroids Specify on the request form and on the urine container the patient's age, sex, and the total 24-hour 24 Hour Urine urine volume. Transport refrigerated (cold packs). Specimen Stability: Room Temperature: 8 hours Refrigerated: 7 days Frozen: 30 days (-20c) Test Code: CHANTILLY T.C. 2796 Processing: Mix sample well and Aliquot 20 mL urine into sterile leak proof urine cup. Note on sample total volume and preservative used during collection. Transport: Refrigerate if held Preferred Collection/Volume: RED 10 No Gel Barrier Tubes Volume: 2.0 mL Serum TAT: Report available: 6 Days Test Schedule: Monday, Thursday Night Method: Liquid Chromatography/Tandem Mass Spectrometry Test Facility: Quest Diagnostics Nichols Inst San Juan Capistrano 33608 Ortega Highway San Juan Capistrano, CA 92690-6130 file:///C:/Users/D111011/AppData/Local/Temp/notes6018E4/PinfoPortal_031515.html 4/23/2015 Page 3 of 368 Clinical Data: 17-Hydroxypregnenolone is useful in the diagnosis of 3-Beta-Hydroxylase enzyme deficiency, a rare cause of congenital adrenal hyperplasia, and 17-Hydroxylase (P450c17) enzyme deficiency. Specimen Stability: Room Temperature: 24 hours 17- Refrigerated: 5 days Hydroxypregnenolone Frozen: 28 days Test Code: SJC T.C.8352X Processing: Centrifuge and aliquot into Referred Tests aliquot tube. Transport: Refrigerate if held. Preferred Collection/Volume: 24 Hour Urine Container Volume: 100.0 mL 24-Hour Urine Instructions: Preserve with 25 mL 50% Acetic Acid (preferred) or 1 gram Boric Acid/100 mL (acceptable) during collection. TAT: Report available: Next Day Test Schedule: Wednesday Evening Method: Colorimetric Test Facility: Quest Diagnostics Nichols Institute 17-Ketogenic Steroids 14225 Newbrook Drive Chantilly, VA 20153 24 Hour Urine Please specify on the request form and on the urine container the patient's age and sex and the total 24-hour urine volume. Transport at room temperature. Test Code: CHANTILLY T.C. 2806 Processing: Mix sample well and Aliquot 20 mL urine into sterile leak proof urine cup. Note on sample total volume and preservative used during collection. Transport: Send Room Temperature Preferred Collection/Volume: Preserve 24-hour urine with 25 mL 50% Acetic Acid (preferred) or with 30 mL 6N HCl or 10 g Boric Acid (acceptable) during collection. 24 Hour Urine Container Volume: 20.0 mL of 24-Hour Urine TAT: Report available: Next Day Test Schedule: Monday-Thursday, Sunday Evening Method: Colorimetric Test Facility: Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153 17-Ketosteroids Total 24 Hour Urine Please specify on the request form and on the urine container the patient's age and sex and the total 24-hour urine volume. Specimen Stability: Room Temperature: 8 hours Refrigerated: 1 week Frozen: 1 month (-20c) Test Code: CHANTILLY T.C. 2776 Processing: Mix sample well and Aliquot 20 mL urine into sterile leak proof urine cup. Note on sample total volume and preservative used during collection. Transport: Refrigerate if held. Preferred Collection: Patient will present for collection between 9 and 13 weeks 6 days gestation. file:///C:/Users/D111011/AppData/Local/Temp/notes6018E4/PinfoPortal_031515.html 4/23/2015 Page 4 of 368 Volume: Filled blood spots on the NTD Laboratories filter paper card. NOTE: Obtain "NTD Laboratories" filter paper card previously completed by the provider for the specific patient in the lab's on-site files. If the form is not found in the on-site file, call Genetic Screening at PNS 503-296-1513 or 503-296-1500. They will get the form to the lab as quickly as possible. Testing Location: NDT Laboratory 80 Ruland Road. Suite 1 Melville, NY 11747 Tel: 1-888-NTD-LABS (1-888-683-5227) Clinical Data: First Trimester Screen | Fß test reliably assesses a mother's risk for having a baby with Down syndrome, trisomy 18 and 13 in the first trimester of pregnancy. Performed between 11 weeks, 1 day and 13 weeks, 6 days gestation, the First Trimester Screen | Fß uses data from a blood test (biochemistry) and an ultrasound examination (biophysical) which yields a risk assessment that physicians may present to their patients during the first trimester. First Trimester Screen | Fß with Instant Risk Assessment enables trained medical professionals to present a complete risk assessment for Down syndrome and trisomy 18 and 13. Performed between 9 weeks and 13 weeks, 6 days of 1st Trimester Screen for gestation, the Instant Risk Assessment provides a care path for Down syndrome Downs Syndrome, risk assessment that is logistically simple to integrate within your overall prenatal Trisomy 18 care plan. In the earlier stages of the pregnancy (9 weeks to 11 weeks, 1 day), a dried blood sample obtained through a simple, safe finger stick method or venous blood may also be used to spot the dried blood spot card through the use of a Diff-Safe device. Dried blood sampling provides a more beneficial way to collect, store and process maternal blood specimens. Maternal blood samples are spotted onto an absorbent test card. This test card also functions as a hard copy data record of the patient's information including history, billing information, ultrasound dates and consent. After the blood spot collection is done, the cards are sent directly to NTD Labs where they are processed, tested and archived according to protocol. The results of the blood screen are maintained at NTD Labs and made available to the physician when the patient undergoes her NT (and optional fetal nasal bone assessment) ultrasound exam between 11 weeks, 1 day and 13 weeks, 6 days of gestation. To save time, NTD Labs provides web-based access to your patient's biochemistry data through a secure Instant Risk Assessment website. This site provides information management tools that allow you to call up individual patient records, enter key biophysical data from the ultrasound, and then present a complete risk assessment for Down syndrome and trisomy 18 and 13 at the time of the patient's visit. The calculation is based upon your patient's data entered on the spot, so there is less time spent between results reporting and patient notification. SPECIMEN STABILITY: ROOM TEMP Ship STAT specimens overnight via Fed Ex. Transport: Send Room Temperature Preferred Collection/Volume: 24 hour urine collected with preservative Volume: 10.0 mL u file:///C:/Users/D111011/AppData/Local/Temp/notes6018E4/PinfoPortal_031515.html 4/23/2015 Page 5 of 368 Prepare sample container for 24-hour urine with 15 g Boric Acid or 25 mL 6N HCl to maintain a pH below 3.
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