bioRxiv preprint doi: https://doi.org/10.1101/656892; this version posted May 31, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 1 2 The Dps4 from Nostoc punctiforme ATCC 29133 is a member of His-type FOC containing Dps 3 protein class that can be broadly found among cyanobacteria 4 5 Christoph Howe1, Vamsi K. Moparthi1#, Felix M. Ho1, Karina Persson2* and Karin Stensjö1* 6 7 1Department of Chemistry-Ångström Laboratory, Uppsala University, Uppsala, Sweden 8 2Department of Chemistry, Umeå University, Umeå, Sweden 9 10 #Current address: Department of Physics, Chemistry and Biology, Division of Chemistry, 11 Linköping University, Linköping, Sweden. 12 13 *Corresponding authors: 14 E-mail:
[email protected] (KS),
[email protected] (KP) 15 16 17 18 19 20 21 22 23 1 bioRxiv preprint doi: https://doi.org/10.1101/656892; this version posted May 31, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 24 Abstract 25 Dps proteins (DNA-binding proteins from starved cells) have been found to detoxify H2O2. At 2+ 26 their catalytic centers, the ferroxidase center (FOC), Dps proteins utilize Fe to reduce H2O2 27 and therefore play an essential role in the protection against oxidative stress and maintaining 28 iron homeostasis.