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534.1.Full.Pdf 534 Thursday, 14 June 2018 Scientific Abstracts Ann Rheum Dis: first published as 10.1136/annrheumdis-2018-eular.6917 on 12 June 2018. Downloaded from 1.65; 95% CI 1.29–2.09); this was not observed in HFpEF (RR 0.80; 95% CI 63 (19.4%) had RA, 58 (17.8%) had pSS, 47 (14.5%) had SLE. Overall, 98 0.63–1.01). Following HF diagnosis, RA patients were more likely to be hospital- (30.2%) patients died. The survival rate of pSS-ILD(85.1%) and SLE-ILD(79.3%) ised for non-cardiovascular causes (RR 1.26; 95% CI 1.14–1.39), but not for HF were significantly higher than other CTD-ILDs [SSc-ILD(68.5%), RA-ILD(66.7%), (RR 0.96; 95% CI 0.76–1.21) or other cardiovascular causes (RR 0.99; 95% CI PM/DM-ILD(58.6%), p=0.009]. However, after categorised into three different ILD 0.81–1.20) compared to the non-RA patients. Readmission rates within 30 days imaging subtypes, it showed no statistical differences in survival rates (64.5%, of prior discharge were similar in RA and non-RA (p=0.14). Smoking (current or 73.6%, 69.5% of the UIP group, NSIP group, indeterminate group, respectively, former), prior myocardial infarction (MI) and higher score on Charlson comorbidity p=0.558). Multivariable analysis revealed that compared with DM/PM-ILD, the index were associated with increased risk for hospitalisation: hazard ratio (HR) mortality rate was significantly lower in pSS-ILD(RR=0.321, p=0.001), RA-ILD 1.33, 95% CI 1.06–1.68; HR 1.37, 95% CI 1.03–1.82; and HR 1.10, 95% CI 1.06– (RR=0.466, p=0.016), SSc-ILD(RR=0.566, p=0.045), and SLE-ILD patients 1.14, respectively. (RR=0.363, p=0.018), and old age(RR=1.028, p=0.002), long course of disease (RR=1.004, p=0.005), extended ILD lesions(RR=1.854, p=0.025) were independ- ent predictors of mortality in all types of CTD-ILD. The present study shows DM/ PM-ILD patients had the worst prognosis then pSS-ILD, RA-ILD, SSc-ILD, and SLE-ILD patients. Age, disease course, intensity of ILD lesions at baseline is also critical for the survival of CTD-ILD patients. Conclusions: The present study shows DM/PM-ILD patients had the worst prog- nosis then pSS-ILD, RA-ILD, SSc-ILD, and SLE-ILD patients. Age, disease course, intensity of ILD lesions at baseline is also critical for the survival of CTD- ILD patients. REFERENCE: [1] Travis WD, Costabel U,et al. An official American Thoracic Society/Euro- pean Respiratory Society statement: Update of the international multidisci- plinary classification of the idiopathic interstitial pneumonias.Am J Respir Crit Care Med 2013 Sep 15;188(6):733–48. Acknowledgements: We would like to thank Drs Zhenjun Zhao and Qian Liu for their review of the high-resolution computed tomography of lung images. Disclosure of Interest: None declared Conclusions: Hospitalisation rate following HF diagnosis was 16% higher in RA DOI: 10.1136/annrheumdis-2018-eular.6917 than in non-RA patients regardless of sex and age. This difference was particu- larly apparent between 1990 and 2010. Increased hospitalisation risk was mostly among patients with RA who had HFrEF rather than HFpEF, and was predomi- THU0681 ESTABLISHING THE BATH ANKYLOSING SPONDYLITIS nantly due to non-cardiovascular causes. Smoking, prior MI and Charlson comor- METROLOGY INDEX (BASMI) NORMATIVE VALUES IN A bidity index were associated with increased risk of hospitalisation suggesting that MALAYSIAN POPULATION: THE IMPORTANCE OF SEX increased complexity of management of patients with comorbid RA may play a AND AGE FACTORS role in more frequent hospitalizations in the RA cohort. A.F. Nurul Aain1,I.S.Lau2,S.C.Gun3,S.Wahinuddin4,P.S.Ong4, H. Heselynn5, B.E. Tan6,H.C.Chong7,A.Hilmi8, M. Asmah9, M.I. Asmahan10,Y.L.Loh11,A. Disclosure of Interest: None declared L. Lim12, H. Noor Shahrazat13,C.L.Teh14,G.R.Ling15,E.Y.Y.Chong16,A. DOI: 10.1136/annrheumdis-2018-eular.3808 H. Ruhaila17, A.M. Suhaida18,R.Shamala5,R.Azmillah19, M.Z. Mollyza19, S. Salsabil1,L.K.Tan1, M. Shahnaz20,C.L.Too1. 1Allergy and Immunology Research Centre, Institute for Medical Research (IMR), Kuala Lumpur; 2Department of Medicine, Selayang Hospital, Selangor; 3Department of Medicine, THURSDAY, 14 JUNE 2018 Hospital Tuanku Jaafar, Negeri Sembilan; 4Department of Medicine, Raja Epidemiology, risk factors for disease or disease Permaisuri Bainun Hospital, Ipoh, Perak; 5Department of Medicine, Putrajaya Hospital, Putrajaya; 6Department of Medicine, Penang Hospital, Pulau Pinang; progression http://ard.bmj.com/ 7Department of Medicine, Malacca Hospital, Malacca; 8Department of Medicine, Hospital Tengku Ampuan Afzan, Kuantan, Pahang; 9Department of Medicine, THU0680 SURVIVAL ANALYSIS OF PATIENTS WITH CONNECTIVE Hospital Sultanah Nur Zahirah, Kuala Terengganu, Terengganu; 10Department of TISSUE DISEASE ASSOCIATED INTERSTITIAL LUNG Medicine, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan; 11Department DISEASE of Medicine, Hospital Sultan Ismail, Johor Bahru; 12Department of Medicine, 13 T. Xu, X. ZHANG. Rheumatoimmunologic Department, Guangdong Academy of Hospital Sultanah Bahiyah; Department of Medicine, Hospital Sultanah Bahiyah, 14 Medical Sciences, Guangdong General Hospital, Guangzhou, China Alor Setar, Kedah; Department of Medicine, Sarawak General Hospital; 15Department of Medicine, Sibu Hospital, Sarawak; 16Department of Medicine, Background: Interstitial lung disease (ILD) is common in connective tissue dis- Queen Elizabeth Hospital, Sabah; 17Department of Medicine, Sultanah Fatimah on October 1, 2021 by guest. Protected copyright. eases (CTDs) and can lead to significant shortened survival. Although the various Specialist Hospital, Muar, Johor; 18Department of Medicine, Hospital Tengku CTDs associated with ILD are often considered as a whole because of their shar- Ampuan Rahimah, Klang, Selangor; 19Department of Medicine, Selayang Hospital, ing the same autoimmune nature, there are substantial differences in the natural Selayang, Selangor; 20Federal Government Administrative Center, Ministry of course in each specific CTD. Still, there is little research comparing the mortalities Health Malaysia, Putrajaya, Malaysia in different underlying CTDs and investigated the risk factors. Objectives: We aimed to examine mortality in patients with ILD secondary to der- Background: Ankylosing spondylitis (AS) is a chronic spinal inflammatory disor- matomyositis and polymyositis(DM/PM), systemic sclerosis(SSc), rheumatoid der which leads to progressive fusion and deformity. The loss of spinal mobility is arthritis(RA), primary Sjögren syndrome (pSS), and systemic lupus erythemato- recognised as an important clinical sign. The BASMI, a composite index of spinal sus(SLE), to test whether the survival was associated with ILD imaging subtypes, mobility is used internationally in clinical practice and research. However, the as well as to identify independent risk factors for CTD-ILDs. interpretation of BASMI has been impeded by the absence of normative values. Methods: We retrospectively reviewed the medical records of patients with newly Objectives: We aimed to attain the normative values for BASMI in Malaysian diagnosed CTD-ILD. The high-resolution computed tomography of lung images healthy individuals. was reviewed by two expert pulmonary radiologists. According to imaging mani- Methods: BASMI data of 142 healthy individuals and 187 AS patients were ana- festations, ILD was categorised into three subtypes,1 i.e., usual interstitial pneu- lysed. Each BASMI component was assessed, using the 10-point scoring system, monitis(UIP), nonspecific interstitial pneumonia(NSIP) and indeterminate, where zero is no mobility and 10 is very severe limitation. Measurements were respectively. The extensity of ILD lesions was also evaluated as grade 1, 2, 3. The performed by the rheumatologists and trained researchers following a designated primary outcome assessed was all-cause mortality. We examined survival after protocol. Data were summarised and analysed according to sex and age groups. stratifying on each specific CTD, or lung-CT imaging subtypes, respectively. We Results: The total BASMI scores ranged from 0.2 to 4.2 and 0.6 to 9.6 in the used Cox proportional hazards model to identify independent predictors of healthy individuals and the AS cases, respectively. There was no significant differ- survival. ence for the BASMI median score between healthy men and women (men=1.2, Results: Three hundred and twenty-five patients were included with a median fol- women=1.6, p>0.05). The estimated median score for healthy individuals aged – low-up time of 54 months. Eighty-four(25.8%) had DM/PM, 73 (22.5%) had SSc, 15 19 years was 1.2, increasing with age to 2.7 for healthy individuals aged 60.
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