Radiation-Associated Synovial Sarcoma
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Expression of ALK1 and P80 in Inflammatory Myofibroblastic Tumor and Its Mesenchymal Mimics: a Study of 135 Cases Melissa H
Expression of ALK1 and p80 in Inflammatory Myofibroblastic Tumor and Its Mesenchymal Mimics: A Study of 135 Cases Melissa H. Cessna, M.D., Holly Zhou, M.D., Warren G. Sanger, Ph.D., Sherrie L. Perkins, M.D., Ph.D., Sheryl Tripp, M.T., Diane Pickering, M.S., Clark Daines, M.D., Cheryl M. Coffin, M.D. Department of Pathology, Primary Children’s Medical Center and University of Utah School of Medicine, Salt Lake City, Utah (MHC, HZ, SLP, ST, CD, CMC); and Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska (WGS, DP) between structural abnormalities involving 2p23 or Abnormalities of chromosome 2p23 with expres- additional copies of 2p23, it supports the concept of sion of ALK1 and p80 occur in both inflammatory ALK involvement in a larger group of neoplasms, myofibroblastic tumor (IMT) and anaplastic large some of which have other documented clonal ab- cell lymphoma. This immunohistochemical study normalities. In IMT, immunohistochemistry for investigates whether the ALK family of neoplasms ALK1 and p80 is useful as an indicator of a 2p23 includes fibroblastic–myofibroblastic, myogenic, abnormality, but it must be interpreted in the con- and spindle cell tumors. Formalin-fixed paraffin- text of histologic and other clinicopathologic data if embedded archival tissues from 10 IMTs and 125 used as an adjunct to differential diagnosis. other soft tissue tumors were stained for ALK1 and p80 with standard immunohistochemistry. ALK1 KEY WORDS: ALK gene rearrangements, ALK im- and/or p80 reactivity was observed in a cytoplasmic munohistochemistry, Anaplastic large cell lym- pattern in IMT (4/10; 40%), malignant peripheral phoma, Inflammatory myofibroblastic tumor. -
Mixed Hepatoblastoma in the Adult: Case Report and Review of the Literature
J Clin Pathol: first published as 10.1136/jcp.33.11.1058 on 1 November 1980. Downloaded from J Clin Pathol 1980;33:1058-1063 Mixed hepatoblastoma in the adult: case report and review of the literature RP HONAN AND MT HAQQANI From the Department of Pathology, Walton Hospital, Rice Lane, Liverpool L9 JAE, UK SUMMARY A case of mixed hepatoblastoma in a woman is described. A survey of the English literature reveals 13 cases acceptable as mixed hepatoblastoma; these have been described and published under a variety of names. Difficulties in nomenclature and the histology of these cases are discussed. Diagnosis depends on the identification of both malignant mesenchymal and malignant epithelial elements. The former include myxoid connective tissue resembling primitive mesenchyme and areas resembling adult fibrosarcoma. Mature fibrous tissue with calcification and bone for- mation may be seen. Epithelial areas show tissue resembling fetal liver, poorly differentiated epithelial cells, and/or areas of adenocarcinoma. The current view on histogenesis is also given. Most hepatoblastomas occur in children under the mixedtumour,6carcino-osteochondromyxosarcoma,5 copyright. age of 2 years.' Hepatoblastoma in adults is ex- and rhabdomyosarcohepatoma.7 tremely rare, and the prognosis is much worse than in the mixed hepatoblastoma of childhood. Case report The literature of mixed hepatoblastoma in adults has until recently been confused, and the true inci- CLINICAL PRESENTATION dence of the tumour obscured, owing to the various A Chinese woman aged 27 had been resident in names used by different authors to describe their England for eight years. She gave a history of cases. The commonest pseudonym is 'mixed malig- 18 months' intermittent right-sided chest pain http://jcp.bmj.com/ nant tumour',2-4 an ambivalent term which merely and upper abdominal discomfort. -
Soft Tissue Cytopathology: a Practical Approach Liron Pantanowitz, MD
4/1/2020 Soft Tissue Cytopathology: A Practical Approach Liron Pantanowitz, MD Department of Pathology University of Pittsburgh Medical Center [email protected] What does the clinician want to know? • Is the lesion of mesenchymal origin or not? • Is it begin or malignant? • If it is malignant: – Is it a small round cell tumor & if so what type? – Is this soft tissue neoplasm of low or high‐grade? Practical diagnostic categories used in soft tissue cytopathology 1 4/1/2020 Practical approach to interpret FNA of soft tissue lesions involves: 1. Predominant cell type present 2. Background pattern recognition Cell Type Stroma • Lipomatous • Myxoid • Spindle cells • Other • Giant cells • Round cells • Epithelioid • Pleomorphic Lipomatous Spindle cell Small round cell Fibrolipoma Leiomyosarcoma Ewing sarcoma Myxoid Epithelioid Pleomorphic Myxoid sarcoma Clear cell sarcoma Pleomorphic sarcoma 2 4/1/2020 CASE #1 • 45yr Man • Thigh mass (fatty) • CNB with TP (DQ stain) DQ Mag 20x ALT –Floret cells 3 4/1/2020 Adipocytic Lesions • Lipoma ‐ most common soft tissue neoplasm • Liposarcoma ‐ most common adult soft tissue sarcoma • Benign features: – Large, univacuolated adipocytes of uniform size – Small, bland nuclei without atypia • Malignant features: – Lipoblasts, pleomorphic giant cells or round cells – Vascular myxoid stroma • Pitfalls: Lipophages & pseudo‐lipoblasts • Fat easily destroyed (oil globules) & lost with preparation Lipoma & Variants . Angiolipoma (prominent vessels) . Myolipoma (smooth muscle) . Angiomyolipoma (vessels + smooth muscle) . Myelolipoma (hematopoietic elements) . Chondroid lipoma (chondromyxoid matrix) . Spindle cell lipoma (CD34+ spindle cells) . Pleomorphic lipoma . Intramuscular lipoma Lipoma 4 4/1/2020 Angiolipoma Myelolipoma Lipoblasts • Typically multivacuolated • Can be monovacuolated • Hyperchromatic nuclei • Irregular (scalloped) nuclei • Nucleoli not typically seen 5 4/1/2020 WD liposarcoma Layfield et al. -
The Health-Related Quality of Life of Sarcoma Patients and Survivors In
Cancers 2020, 12 S1 of S7 Supplementary Materials The Health-Related Quality of Life of Sarcoma Patients and Survivors in Germany—Cross-Sectional Results of A Nationwide Observational Study (PROSa) Martin Eichler, Leopold Hentschel, Stephan Richter, Peter Hohenberger, Bernd Kasper, Dimosthenis Andreou, Daniel Pink, Jens Jakob, Susanne Singer, Robert Grützmann, Stephen Fung, Eva Wardelmann, Karin Arndt, Vitali Heidt, Christine Hofbauer, Marius Fried, Verena I. Gaidzik, Karl Verpoort, Marit Ahrens, Jürgen Weitz, Klaus-Dieter Schaser, Martin Bornhäuser, Jochen Schmitt, Markus K. Schuler and the PROSa study group Includes Entities We included sarcomas according to the following WHO classification. - Fletcher CDM, World Health Organization, International Agency for Research on Cancer, editors. WHO classification of tumours of soft tissue and bone. 4th ed. Lyon: IARC Press; 2013. 468 p. (World Health Organization classification of tumours). - Kurman RJ, International Agency for Research on Cancer, World Health Organization, editors. WHO classification of tumours of female reproductive organs. 4th ed. Lyon: International Agency for Research on Cancer; 2014. 307 p. (World Health Organization classification of tumours). - Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE. The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part B: Prostate and Bladder Tumours. Eur Urol. 2016 Jul;70(1):106–19. - World Health Organization, Swerdlow SH, International Agency for Research on Cancer, editors. WHO classification of tumours of haematopoietic and lymphoid tissues: [... reflects the views of a working group that convened for an Editorial and Consensus Conference at the International Agency for Research on Cancer (IARC), Lyon, October 25 - 27, 2007]. 4. ed. -
Fascin‑1 Is Associated with Recurrence in Solitary Fibrous Tumor/Hemangiopericytoma
MOLECULAR AND CLINICAL ONCOLOGY 15: 199, 2021 Fascin‑1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma YUMIKO YAMAMOTO1, YOSHIHIRO HAYASHI2, HIDEYUKI SAKAKI3 and ICHIRO MURAKAMI1,4 1Department of Diagnostic Pathology, Kochi University Hospital, Kochi University; 2Equipment of Support Planning Office, Kochi University, Nankoku, Kochi 783‑8505; 3Department of Nutritional Sciences for Well‑being Health, Kansai University of Welfare Sciences, Kashiwa, Osaka 582‑0026; 4Department of Pathology, School of Medicine, Kochi University, Nankoku, Kochi 783‑8505, Japan Received March 31, 2021; Accepted July 15, 2021 DOI: 10.3892/mco.2021.2361 Abstract. Fascin‑1, an actin‑bundling protein, is associated epithelial membrane antigen (1‑5). This lack of specificity in with poor prognosis in patients with various types of SFT/HPC occasionally caused problems in differentiating human carcinoma. However, research is limited on the role them from other tumors that are immunohistologically alike of fascin‑1 in sarcoma. Solitary fibrous tumor (SFT) and them. In 2013, three groups reported that SFT and HPC have hemangiopericytoma (HPC) are rare sarcomas derived from the a common gene fusion between NGFI‑A‑binding protein 2 mesenchyme. Although the prognosis of SFT/HPC is generally (NAB2) and signal transducer and activator of transcription 6 favorable, fatalities are possible with repeated recurrence (STAT6) (1,6,7). Thereafter, STAT6, which has dual functions and distant metastasis. The current study included a total of as a signal transducer and as transcription activator in SFT 20 Japanese patients, who were diagnosed with SFT/HPC and and HPC, was recognized as the highly sensitive and specific underwent surgery at Kochi University Hospital from January immunohistochemical marker for SFT/HPC (2‑5,8‑11). -
Synovial Sarcoma of the Upper Digestive Tract: a Report of Two Cases with Demonstration of the X;18 Translocation by Fluorescence in Situ Hybridization Steven D
Synovial Sarcoma of the Upper Digestive Tract: A Report of Two Cases with Demonstration of the X;18 Translocation by Fluorescence In Situ Hybridization Steven D. Billings, M.D., Lorraine F. Meisner, Ph.D., Oscar W. Cummings, M.D., Eduardo Tejada, M.D. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine (SDB, OWC), Indianapolis, Indiana; University of Wisconsin, Department of Pathology and Laboratory Medicine and the State Laboratory of Hygiene (LFM), Madison, Wisconsin; and Department of Pathology, Indiana University School of Medicine and the Laboratory Service, Richard L. Roudebush Veterans Affairs Medical Center (ET), Indianapolis, Indiana differential diagnoses for synovial sarcoma in this Two cases of synovial sarcoma that arose in the site. Synovial sarcoma of the digestive tract may be upper digestive tract are reported. One case was a underdiagnosed, and its recognition may have im- polypoid mass that arose at the gastroesophageal portant clinical implications. Fluorescence in situ junction; the other was a large intramural mass that hybridization is helpful in making this distinction. arose in the wall of the stomach. Both cases had a classic biphasic pattern. In the stomach tumor, the KEY WORDS: Chromosomal translocation, Esopha- biphasic morphology was focal and there was an geal neoplasms, Fluorescence in situ hybridization, abrupt transition to poorly differentiated synovial Immunohistochemistry, Stomach neoplasms, Sy- sarcoma. The tumors had immunohistochemical novial sarcoma. features that were consistent with synovial sar- Mod Pathol 2000;13(1):68–76 coma. Ultrastructural evaluation of the gastro- esophageal tumor supported the diagnosis. The di- Synovial sarcomas are malignant mesenchymal tu- agnostic X;18 translocation was demonstrated by fluorescence in situ hybridization on sections from mors of uncertain histogenesis. -
Morphological and Immunohistochemical Characteristics of Surgically Removed Paediatric Renal Tumours in Latvia (1997–2010)
DOI: 10.2478/v10163-012-0008-6 ACTA CHIRURGICA LATVIENSIS • 2011 (11) ORIGINAL ARTICLE Morphological and Immunohistochemical Characteristics of Surgically Removed Paediatric Renal Tumours in Latvia (1997–2010) Ivanda Franckeviča*,**, Regīna Kleina*, Ivars Melderis** *Riga Stradins University, Riga, Latvia **Children’s Clinical University Hospital, Riga, Latvia Summary Introduction. Paediatric renal tumours represent 7% of all childhood malignancies. The variable appearances of the tumours and their rarity make them especially challenging group of lesions for the paediatric pathologist. In Latvia diagnostics and treatment of childhood malignancies is concentrated in Children’s Clinical University Hospital. Microscopic evaluation of them is realised in Pathology office of this hospital. Aim of the study is to analyze morphologic spectrum of children kidney tumours in Latvia and to characterise them from modern positions with wide range of immunohistochemical markers using morphological material of Pathology bureau of Children’s Clinical University Hospital. Materials and methods. We have analyzed surgically removed primary renal tumours in Children Clinical University Hospital from the year 1997 till 2010. Samples were fixed in 10% formalin fluid, imbedded in paraffin and haematoxylin-eosin stained slides were re-examined. Immunohistochemical re-investigation was made in 65.91% of cases. For differential diagnostic purposes were used antibodies for the detection of bcl-2, CD34, EMA, actin, desmin, vimentin, CKAE1/AE3, CK7, Ki67, LCA, WT1, CD99, NSE, chromogranin, synaptophyzin, S100, myoglobin, miogenin, MyoD1 (DakoCytomation) and INI1 protein (Santa Cruz Biotechnology). Results. During the revised period there were diagnosed 44 renal tumours. Accordingly of morphological examination data neoplasms were divided: 1) nephroblastoma – 75%, 2) clear cell sarcoma – 2.27%, 3) rhabdoid tumour – 4.55%, 4) angiomyolipoma – 4.55%, 5) embrional rhabdomyosarcoma – 2.27%, 6) mesoblastic nephroma – 4.55%, 7) multicystic nephroma – 4.55%, 8) angiosarcoma – 2.27%. -
Synovial Sarcoma: Recent Discoveries As a Roadmap to New Avenues for Therapy
Published OnlineFirst January 22, 2015; DOI: 10.1158/2159-8290.CD-14-1246 REVIEW Synovial Sarcoma: Recent Discoveries as a Roadmap to New Avenues for Therapy Torsten O. Nielsen 1 , Neal M. Poulin 1 , and Marc Ladanyi 2 ABSTRACT Oncogenesis in synovial sarcoma is driven by the chromosomal translocation t(X,18; p11,q11), which generates an in-frame fusion of the SWI/SNF subunit SS18 to the C-terminal repression domains of SSX1 or SSX2. Proteomic studies have identifi ed an integral role of SS18–SSX in the SWI/SNF complex, and provide new evidence for mistargeting of polycomb repression in synovial sarcoma. Two recent in vivo studies are highlighted, providing additional support for the importance of WNT signaling in synovial sarcoma: One used a conditional mouse model in which knock- out of β-catenin prevents tumor formation, and the other used a small-molecule inhibitor of β-catenin in xenograft models. Signifi cance: Synovial sarcoma appears to arise from still poorly characterized immature mesenchymal progenitor cells through the action of its primary oncogenic driver, the SS18–SSX fusion gene, which encodes a multifaceted disruptor of epigenetic control. The effects of SS18–SSX on polycomb-mediated gene repression and SWI/SNF chromatin remodeling have recently come into focus and may offer new insights into the basic function of these processes. A central role for deregulation of WNT–β-catenin sig- naling in synovial sarcoma has also been strengthened by recent in vivo studies. These new insights into the the biology of synovial sarcoma are guiding novel preclinical and clinical studies in this aggressive cancer. -
Dermatofibrosarcoma Protuberans of the Parotid Gland -A Case Report
The Korean Journal of Pathology 2004; 38: 276-9 Dermatofibrosarcoma Protuberans of the Parotid Gland -A Case Report - Ok-Jun Lee∙David Y. Pi∙ Dermatofibrosarcoma protuberans (DFSP) typically presents during the early or mid-adult life, Daniel H. Jo∙Kyung-Ja Cho and the most common site of origin is the skin on the trunk and proximal extremities. DFSP of Sang Yoon Kim1∙Jae Y. Ro the parotid gland is extremely rare and only one case has been reported in the literature. We present here a case of a 30-year-old woman with DFSP occurring in the parotid gland, and we Departments of Pathology and discuss the differential diagnosis. The patient is alive and doing well one year after her operation. 1Otolaryngology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea Received : January 27, 2004 Accepted : July 5, 2004 Corresponding Author Jae Y. Ro, M.D. Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea Tel: 02-3010-4550 Fax: 02-472-7898 E-mail: [email protected] Key Words : Dermatofibrosarcoma Protuberans-Parotid Gland Epithelial tumors make up the majority of salivary gland neo- CASE REPORT plasms, while mesenchymal tumors of this organ are uncommon. Dermatofibrosarcoma protuberans (DFSP) of the salivary gland A 30-year-old woman came to the Otolaryngology Clinic at is exremely rare and only one case has been reported in the parotid the Asan Medical Center with a 2-year history of a slowly enlarg- gland.1 ing mass inferior to the left angle of the mandible. -
Rates of Cell Division of Transplantable Malignant Rat Tumors*
Rates of Cell Division of Transplantable Malignant Rat Tumors* FELIXD. BERTALANFFYANDCHOSENLAU (Department of Anatomy, Faculties of Medicine and Dentistry, Unirersity of Manitoba, Winnipeg, Manitoba, Canada) SUMMARY The mitotic rates of transplantable Walker carcinosarcoma 256 and fibrosarcoma 1F16F were investigated in rats by the colchicine method. The mitotic rates of these tumors were apparently not influenced by the time of day. In female rats the estrous cycle did not seem to have appreciable effects on the mitotic rates of fibrosarcoma. During the period of active growth of the tumors a constant increase in the number of cells occurred each day until the onset of necrosis. During the 5th-10th day after transplantation about 60 per cent of the cells divided daily in Walker carcinosarcoma. During the growth period of the fibrosarcoma—i.e., from the 15th to the 32d day after transplantation—about 40 per cent of newly formed cells were daily added to this tumor. These figures imply that the cell population of Walker tumor doubles about every 1.7 days, of the fibrosarcoma every 2.5 days. The mitotic rates of these malig nant tumors exceed those of most normal tissues and are surpassed only by those of the epithelium (crypts) in the small intestine. Tumor growth has been quantitatively esti plicable only to solid tumors. Disadvantages were mated by a variety of methods. Radioactive trac that malignant tumors rarely are exactly spheri ers, such as tritiated thymidine (e.g., 11), spectro- cal, cylindrical, or conical, as is requisite for the photometric determination (e.g., 22, 23) of DNA application of the above formulas. -
About Soft Tissue Sarcoma Overview and Types
cancer.org | 1.800.227.2345 About Soft Tissue Sarcoma Overview and Types If you've been diagnosed with soft tissue sarcoma or are worried about it, you likely have a lot of questions. Learning some basics is a good place to start. ● What Is a Soft Tissue Sarcoma? Research and Statistics See the latest estimates for new cases of soft tissue sarcoma and deaths in the US and what research is currently being done. ● Key Statistics for Soft Tissue Sarcomas ● What's New in Soft Tissue Sarcoma Research? What Is a Soft Tissue Sarcoma? Cancer starts when cells start to grow out of control. Cells in nearly any part of the body can become cancer and can spread to other areas. To learn more about how cancers start and spread, see What Is Cancer?1 There are many types of soft tissue tumors, and not all of them are cancerous. Many benign tumors are found in soft tissues. The word benign means they're not cancer. These tumors can't spread to other parts of the body. Some soft tissue tumors behave 1 ____________________________________________________________________________________American Cancer Society cancer.org | 1.800.227.2345 in ways between a cancer and a non-cancer. These are called intermediate soft tissue tumors. When the word sarcoma is part of the name of a disease, it means the tumor is malignant (cancer).A sarcoma is a type of cancer that starts in tissues like bone or muscle. Bone and soft tissue sarcomas are the main types of sarcoma. Soft tissue sarcomas can develop in soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues. -
P05: Incidence Rates of Neoplasms by Anatomic Site (Systemic
TDMS No. 88123 - 07 P05: INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC Date Report Reqsted: 05/04/2006 LESIONS ABRIDGED) (a) Test Type: CHRONIC FORMAMIDE Time Report Reqsted: 11:47:08 Route: GAVAGE CAS Number: 75-12-7 First Dose M/F: 10/04/01 / 10/03/01 Species/Strain: MICE/B6C3F1 Pathologist: RYAN, M. - Blackshear, P. Lab: BAT F1_M3 C Number: C88123B Lock Date: 05/24/2004 Cage Range: ALL Date Range: ALL Reasons For Removal: ALL Removal Date Range: ALL Treatment Groups: Include ALL TDMS No. 88123 - 07 P05: INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC Date Report Reqsted: 05/04/2006 LESIONS ABRIDGED) (a) Test Type: CHRONIC FORMAMIDE Time Report Reqsted: 11:47:08 Route: GAVAGE CAS Number: 75-12-7 First Dose M/F: 10/04/01 / 10/03/01 Species/Strain: MICE/B6C3F1 Pathologist: RYAN, M. - Blackshear, P. Lab: BAT B6C3F1 MICE MALE 0 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG Disposition Summary Animals Initially in Study 50 50 50 50 Early Deaths Moribund Sacrifice 4 8 6 14 Natural Death 7 8 3 Survivors Terminal Sacrifice 39 42 36 33 Animals Examined Microscopically 50 50 50 50 ALIMENTARY SYSTEM Esophagus (50) (50) (50) (50) Periesophageal Tissue, 1 (2%) Hepatocholangiocarcinoma, Metastatic, Liver Gallbladder (45) (48) (45) (46) Intestine Large, Cecum (50) (50) (50) (50) Intestine Large, Colon (50) (50) (50) (50) Intestine Large, Rectum (50) (50) (50) (50) Intestine Small, Duodenum (50) (50) (50) (50) Carcinoma, Metastatic, Pancreas 1 (2%) Intestine Small, Ileum (50) (50) (50) (50) Epithelium, Carcinoma 1 (2%) Intestine Small, Jejunum