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Wall Street View Pharmaceutical Executives’ 2013 © yright ibution p istr Co l D nload, rcia n dow Pipelinem Re eeprs caort m us use Co orised sonal or . Auth or per ale hibited copy f r S se pro ingle t fo ised u rint a s AlzhNeimoer’s Daiustehaosre: Movi nangd F porward Un y, view displa Drug Name Company Phase Launch Date Sales Potential Solanezumab III N/A N/A Gantenerumab II/III N/A N/A Hepatitis C: The More the Merrier Drug Name Company Phase Launch Date Sales Potential Sofosbuvir III 2014 Blockbuster Simeprevir/Daclatasvir III 2014/2015 Minibuster ABT-450 III 2015 Blockbuster Setrobuvir/Danoprevir/ II 2015 Minibuster Mericitabine Sovaprevir II N/A N/A Rheumatoid Arthritis: Return of the DMARDS Drug Name Company Phase Launch Date Sales Potential Tofacitinib Preregistration 2012/2013 Blockbuster Baricitinib II N/A N/A Fostamatinib III 2014 Minibuster GLPG 0634 II 2017 N/A Canadian Pharmaceutical Marketing l June/July 2013 7 Wall Street View Cancer: Improving on Innovation Drug Name Company Phase Launch Date Sales Potential GDC-0973 III N/A N/A Dabrafenib Preregistered 2013 Minibuster Trametinib Preregistered 2013 Minibuster Nivolumab II 2015 Blockbuster Trastuzumab Emtansine Preregistration 2013 Blockbuster 3 Radium-223 Chloride III N/A Blockbuster ARN 509 I/II N/A N/A Ponatinib Preregistration 2013 Minibuster Ibrutinib III 2014 Blockbuster Diabetes: Incremental Improvement Drug Name Company Phase Launch Date Sales Potential Tresiba Preregistered 2013 Blockbuster Ryzodeg Preregistered 2013 Blockbuster LY2605541 & LY2963016 III 2015 Blockbuster Canagliflozin Preregistration 2014 Blockbuster 8 Canadian Pharmaceutical Marketing l June/July 2013 Wall Street View Hyperlipidemia: CETP Inhibitors, PCSK9 Inhibitors, and More Drug Name Company Phase Launch Date Sales Potential Alirocumab III 2016 Blockbuster AMG 145 III 2016 Blockbuster Anacetrapib III 2016 Blockbuster Multiple Sclerosis: We’ve Got Your Number Drug Name Company Phase Launch Date Sales Potential Lemtrada Preregistered 2013 Minibuster Laquinimod III 2015 Minibuster Top Therapeutic Areas by Late-stage Products Therapeutic Category Estimated Global Sales 2018 ($US million) Oncology and Immunomodulators 16,668 Central Nervous System 13,891 Systemic Anti-infectives 13,600 Endocrine 7,627 Cardiovascular 5,794 Musculoskeletal 5,647 Respiratory 2,938 Blood 2,386 Late-stage includes Phase III and Filed Forecast data courtesy of EvaluatePharma * Source: Adapted from Pharmaceutical Executive “Pharm Exec’s 2013 Pipeline Report,” written by Ben Comer, Senior Editor, November 2012; Volume 32, Number 11. CPM Canadian Pharmaceutical Marketing l June/July 2013 9.

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Interferon-Based and Interferon-Free New Treatment Options
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ABOUT HIV i-BASE HIV i-Base is a London-based HIV treatment activist organization. HIV i-Base works in the United Kingdom and internationally to ensure that people living with HIV are actively engaged in their own treatment and medical care and are included in policy discussions about HIV treatment recommendations and access. www.i-base.info ABOUT TAG The Treatment Action Group (TAG) is an independent AIDS research and policy think tank fighting for better treatment, a vaccine, and a cure for AIDS. TAG works to ensure that all people with HIV receive lifesaving treatment, care, and information. www.treatmentactiongroup.org 2013 PIPELINE REPORT HIV, HEPATITIS C VIRUS (HCV), AND TUBERCULOSIS (TB) DRUGS, DIAGNOSTICS, VACCINES, PREVENTIVE TECHNOLOGIES, RESEARCH TOWARD A CURE, AND IMMUNE-BASED AND GENE THERAPIES IN DEVELOPMENT By Polly Clayden, Simon Collins, Colleen Daniels, Mike Frick, Mark Harrington, Tim Horn, Richard Jefferys, Karyn Kaplan, Erica Lessem, and Tracy Swan Edited by Andrea Benzacar JUNE 2013 HIV i-BASE/TREATMENT AcTION GROUP AUTHORS Polly Clayden, Simon Collins, Colleen Daniels, Mike Frick, Mark Harrington, Tim Horn, Richard Jefferys, Karyn Kaplan, Erica Lessem, and Tracy Swan EXECUTIVE EDITOR Andrea Benzacar EDITORS Tim Horn and Scott Morgan DESIGNER Lei Chou ACKNOWLEDGMENTS i-Base thanks the Monument Trust and UNITAID for support for this work. Thanks to the TAG staff, board, and donors for supporting the production of the 2013 Pipeline Report. HIV i-Base Treatment Action Group 4th Floor, 57 Great Suffolk Street 261 Fifth
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